ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of action potential (GO:0045760)	9.95413161
2	positive regulation of steroid hormone secretion (GO:2000833)	8.19252946
3	regulation of glucocorticoid secretion (GO:2000849)	8.11260470
4	positive regulation of digestive system process (GO:0060456)	7.90116812
5	positive regulation of synaptic transmission, GABAergic (GO:0032230)	7.59805849
6	negative regulation of heart rate (GO:0010459)	7.14018087
7	negative regulation of translation, ncRNA-mediated (GO:0040033)	7.08506948
8	regulation of translation, ncRNA-mediated (GO:0045974)	7.08506948
9	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	7.08506948
10	regulation of corticosteroid hormone secretion (GO:2000846)	6.46670440
11	attachment of spindle microtubules to kinetochore (GO:0008608)	6.28486879
12	regulation of action potential (GO:0098900)	5.87473191
13	establishment of protein localization to Golgi (GO:0072600)	5.20576717
14	protein targeting to Golgi (GO:0000042)	4.93051403
15	regulation of steroid hormone secretion (GO:2000831)	4.86402913
16	microtubule anchoring (GO:0034453)	4.80909366
17	positive regulation of renal sodium excretion (GO:0035815)	4.78867761
18	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.49926466
19	prenylation (GO:0097354)	4.08580901
20	protein prenylation (GO:0018342)	4.08580901
21	neural tube formation (GO:0001841)	4.01029373
22	nuclear pore organization (GO:0006999)	3.93888005
23	production of molecular mediator involved in inflammatory response (GO:0002532)	3.89430859
24	regulation of telomere maintenance (GO:0032204)	3.82092771
25	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.82007982
26	DNA integration (GO:0015074)	3.75241635
27	protein localization to Golgi apparatus (GO:0034067)	3.51447001
28	response to pheromone (GO:0019236)	3.49148245
29	regulation of male gonad development (GO:2000018)	3.45660060
30	positive regulation of male gonad development (GO:2000020)	3.45614071
31	protein K11-linked deubiquitination (GO:0035871)	3.42948398
32	centrosome localization (GO:0051642)	3.41495538
33	negative regulation of heart contraction (GO:0045822)	3.33234780
34	DNA double-strand break processing (GO:0000729)	3.27639093
35	mitotic metaphase plate congression (GO:0007080)	3.26560944
36	resolution of meiotic recombination intermediates (GO:0000712)	3.23344604
37	metaphase plate congression (GO:0051310)	3.17795826
38	positive regulation of vesicle fusion (GO:0031340)	3.10618791
39	L-glutamate transport (GO:0015813)	3.06404740
40	regulation of renal sodium excretion (GO:0035813)	3.04142014
41	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.98496785
42	histone mRNA catabolic process (GO:0071044)	2.95657644
43	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	2.94438357
44	monoubiquitinated protein deubiquitination (GO:0035520)	2.93300816
45	replication fork processing (GO:0031297)	2.88912084
46	regulation of digestive system process (GO:0044058)	2.86222740
47	heart process (GO:0003015)	2.84284896
48	heart contraction (GO:0060047)	2.84284896
49	negative regulation of axon guidance (GO:1902668)	2.83963284
50	histone H2A acetylation (GO:0043968)	2.83399523
51	acidic amino acid transport (GO:0015800)	2.81947283
52	negative regulation of blood circulation (GO:1903523)	2.79990883
53	glycosphingolipid biosynthetic process (GO:0006688)	2.79285482
54	protein neddylation (GO:0045116)	2.77130287
55	presynaptic membrane assembly (GO:0097105)	2.73417559
56	response to X-ray (GO:0010165)	2.71954600
57	regulation of synaptic transmission, GABAergic (GO:0032228)	2.69406546
58	keratinocyte development (GO:0003334)	2.68887538
59	microtubule nucleation (GO:0007020)	2.68723297
60	intra-Golgi vesicle-mediated transport (GO:0006891)	2.66200582
61	kidney morphogenesis (GO:0060993)	2.65989826
62	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.65872165
63	centriole assembly (GO:0098534)	2.65393470
64	microtubule cytoskeleton organization involved in mitosis (GO:1902850)	2.64687557
65	pantothenate metabolic process (GO:0015939)	2.63493223
66	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.63303532
67	regulation of mitotic spindle checkpoint (GO:1903504)	2.63303532
68	inositol phosphate-mediated signaling (GO:0048016)	2.62771728
69	adaptation of signaling pathway (GO:0023058)	2.62081396
70	double-strand break repair via nonhomologous end joining (GO:0006303)	2.61730705
71	non-recombinational repair (GO:0000726)	2.61730705
72	regulation of protein glycosylation (GO:0060049)	2.60456069
73	regulation of endocrine process (GO:0044060)	2.60172320
74	regulation of establishment of cell polarity (GO:2000114)	2.58112132
75	regulation of excretion (GO:0044062)	2.57421037
76	establishment of chromosome localization (GO:0051303)	2.56461462
77	protein targeting to lysosome (GO:0006622)	2.55869511
78	establishment of protein localization to vacuole (GO:0072666)	2.55869511
79	protein targeting to vacuole (GO:0006623)	2.55869511
80	neuronal action potential propagation (GO:0019227)	2.51397759
81	positive regulation of growth hormone secretion (GO:0060124)	2.50625627
82	positive regulation of developmental pigmentation (GO:0048087)	2.50607552
83	isotype switching (GO:0045190)	2.50307550
84	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.50307550
85	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.50307550
86	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	2.48527630
87	DNA catabolic process, exonucleolytic (GO:0000738)	2.47891120
88	neuron projection extension involved in neuron projection guidance (GO:1902284)	2.47459198
89	axon extension involved in axon guidance (GO:0048846)	2.47459198
90	mesenchymal-epithelial cell signaling (GO:0060638)	2.45418148
91	nerve growth factor signaling pathway (GO:0038180)	2.42172343
92	C4-dicarboxylate transport (GO:0015740)	2.38917405
93	negative regulation of meiosis (GO:0045835)	2.36637716
94	DNA ligation (GO:0006266)	2.36142479
95	methionine biosynthetic process (GO:0009086)	2.35167329
96	ganglion development (GO:0061548)	2.34425799
97	methionine metabolic process (GO:0006555)	2.33686288
98	single strand break repair (GO:0000012)	2.33671200
99	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.32892670
100	tachykinin receptor signaling pathway (GO:0007217)	10.7700446

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.80389722
2	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.53237830
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.22516071
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.98899877
5	FUS_26573619_Chip-Seq_HEK293_Human	2.78173615
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.67633823
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.60997543
8	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.50649735
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.44772303
10	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.35529915
11	VDR_22108803_ChIP-Seq_LS180_Human	2.35265163
12	EWS_26573619_Chip-Seq_HEK293_Human	2.34135126
13	P300_19829295_ChIP-Seq_ESCs_Human	2.33891498
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.27206661
15	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.26726320
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.25353298
17	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.21970171
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.18720228
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.12148287
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.09241088
21	ER_23166858_ChIP-Seq_MCF-7_Human	2.04481690
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.90345571
23	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.88843496
24	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.88319230
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.87912162
26	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.86416750
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.85147924
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.84393766
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.80139959
30	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.77357455
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.75558779
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.70306951
33	STAT3_23295773_ChIP-Seq_U87_Human	1.68143911
34	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.65817753
35	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.62592029
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60501278
37	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.58609441
38	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.58352205
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.58087895
40	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.54809606
41	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.54659052
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54129832
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.52998892
44	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.50409762
45	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.49603318
46	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.48381926
47	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.47336020
48	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.44742524
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.44161363
50	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.43470260
51	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.42792520
52	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.40435002
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39120796
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39120796
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38681999
56	AR_25329375_ChIP-Seq_VCAP_Human	1.37814566
57	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.37443652
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36389612
59	P53_22387025_ChIP-Seq_ESCs_Mouse	1.34592659
60	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.33970827
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33388700
62	TCF4_23295773_ChIP-Seq_U87_Human	1.32225772
63	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.31606419
64	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.30338619
65	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.30338619
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.29335349
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29314710
68	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.27933661
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27616387
70	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.26813833
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.26308179
72	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26308179
73	CDX2_22108803_ChIP-Seq_LS180_Human	1.24779153
74	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.20856653
75	AHR_22903824_ChIP-Seq_MCF-7_Human	1.17482711
76	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.16702169
77	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.14651001
78	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.13741136
79	P300_18555785_Chip-Seq_ESCs_Mouse	1.12703260
80	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.11382676
81	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.10992151
82	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.09675419
83	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.07727441
84	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.07190799
85	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06014330
86	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06014330
87	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.05305563
88	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.04817330
89	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.03596714
90	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.03110677
91	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.03055813
92	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01478855
93	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.00962721
94	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.00917614
95	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00550693
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.99144717
97	BRD4_25478319_ChIP-Seq_HGPS_Human	0.98399656
98	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.98318279
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97888638
100	TP53_18474530_ChIP-ChIP_U2OS_Human	0.97584818

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010386_abnormal_urinary_bladder	9.35171478
2	MP0003787_abnormal_imprinting	5.04353606
3	MP0008877_abnormal_DNA_methylation	3.65246218
4	MP0000569_abnormal_digit_pigmentation	3.30668039
5	MP0002102_abnormal_ear_morphology	3.28014813
6	MP0001529_abnormal_vocalization	2.81720709
7	MP0008058_abnormal_DNA_repair	2.59346557
8	MP0003121_genomic_imprinting	2.25821894
9	MP0005187_abnormal_penis_morphology	2.12140201
10	MP0008057_abnormal_DNA_replication	2.05052839
11	MP0001486_abnormal_startle_reflex	1.90133982
12	MP0001188_hyperpigmentation	1.84609640
13	MP0003950_abnormal_plasma_membrane	1.78581964
14	MP0006072_abnormal_retinal_apoptosis	1.75221419
15	MP0004883_abnormal_blood_vessel	1.68159441
16	MP0000427_abnormal_hair_cycle	1.67273052
17	MP0002751_abnormal_autonomic_nervous	1.66321506
18	MP0003195_calcinosis	1.66067116
19	MP0008789_abnormal_olfactory_epithelium	1.58972207
20	MP0002090_abnormal_vision	1.54795820
21	MP0005248_abnormal_Harderian_gland	1.53751828
22	MP0001756_abnormal_urination	1.48484834
23	MP0001984_abnormal_olfaction	1.48128734
24	MP0002234_abnormal_pharynx_morphology	1.45830658
25	MP0000516_abnormal_urinary_system	1.45120482
26	MP0005367_renal/urinary_system_phenotyp	1.45120482
27	MP0003880_abnormal_central_pattern	1.38928950
28	MP0003122_maternal_imprinting	1.32347464
29	MP0005253_abnormal_eye_physiology	1.26174744
30	MP0004270_analgesia	1.25705751
31	MP0005084_abnormal_gallbladder_morpholo	1.25693947
32	MP0001485_abnormal_pinna_reflex	1.24159043
33	MP0006035_abnormal_mitochondrial_morpho	1.22290953
34	MP0006276_abnormal_autonomic_nervous	1.21925129
35	MP0003828_pulmonary_edema	1.20037433
36	MP0010094_abnormal_chromosome_stability	1.18985972
37	MP0009697_abnormal_copulation	1.16447581
38	MP0000647_abnormal_sebaceous_gland	1.14048650
39	MP0003786_premature_aging	1.13817079
40	MP0005551_abnormal_eye_electrophysiolog	1.13696278
41	MP0009046_muscle_twitch	1.06239952
42	MP0004084_abnormal_cardiac_muscle	1.06182371
43	MP0003252_abnormal_bile_duct	1.01554416
44	MP0002009_preneoplasia	1.00795699
45	MP0004043_abnormal_pH_regulation	0.99720967
46	MP0006054_spinal_hemorrhage	0.98233224
47	MP0002233_abnormal_nose_morphology	0.97881048
48	MP0002163_abnormal_gland_morphology	0.93516029
49	MP0003879_abnormal_hair_cell	0.93407922
50	MP0002184_abnormal_innervation	0.91622673
51	MP0004133_heterotaxia	0.89819862
52	MP0001919_abnormal_reproductive_system	0.88067206
53	MP0002168_other_aberrant_phenotype	0.87944027
54	MP0003718_maternal_effect	0.87881302
55	MP0005389_reproductive_system_phenotype	0.86584528
56	MP0000631_abnormal_neuroendocrine_gland	0.85931201
57	MP0000538_abnormal_urinary_bladder	0.84589099
58	MP0009745_abnormal_behavioral_response	0.84415933
59	MP0001968_abnormal_touch/_nociception	0.84403963
60	MP0000383_abnormal_hair_follicle	0.83812432
61	MP0003567_abnormal_fetal_cardiomyocyte	0.83743225
62	MP0003221_abnormal_cardiomyocyte_apopto	0.83562716
63	MP0003937_abnormal_limbs/digits/tail_de	0.83162298
64	MP0005379_endocrine/exocrine_gland_phen	0.82044300
65	MP0001501_abnormal_sleep_pattern	0.81968817
66	MP0005395_other_phenotype	0.81700110
67	MP0004924_abnormal_behavior	0.80739713
68	MP0005386_behavior/neurological_phenoty	0.80739713
69	MP0005164_abnormal_response_to	0.79793973
70	MP0002272_abnormal_nervous_system	0.79458391
71	MP0002160_abnormal_reproductive_system	0.79322563
72	MP0002734_abnormal_mechanical_nocicepti	0.78449499
73	MP0002736_abnormal_nociception_after	0.76275436
74	MP0005394_taste/olfaction_phenotype	0.74563750
75	MP0005499_abnormal_olfactory_system	0.74563750
76	MP0001849_ear_inflammation	0.74243502
77	MP0004484_altered_response_of	0.73034170
78	MP0000230_abnormal_systemic_arterial	0.71474676
79	MP0003890_abnormal_embryonic-extraembry	0.70124911
80	MP0005376_homeostasis/metabolism_phenot	0.68639495
81	MP0005075_abnormal_melanosome_morpholog	0.68627335
82	MP0000653_abnormal_sex_gland	0.67761310
83	MP0003119_abnormal_digestive_system	0.67047873
84	MP0003283_abnormal_digestive_organ	0.66539496
85	MP0005332_abnormal_amino_acid	0.65833061
86	MP0004142_abnormal_muscle_tone	0.65380358
87	MP0010678_abnormal_skin_adnexa	0.65072471
88	MP0003137_abnormal_impulse_conducting	0.64668589
89	MP0004742_abnormal_vestibular_system	0.64311663
90	MP0002938_white_spotting	0.64258631
91	MP0001502_abnormal_circadian_rhythm	0.63510369
92	MP0003385_abnormal_body_wall	0.63209954
93	MP0000049_abnormal_middle_ear	0.62141784
94	MP0008995_early_reproductive_senescence	0.61211971
95	MP0005266_abnormal_metabolism	0.60283040
96	MP0001764_abnormal_homeostasis	0.59198101
97	MP0002837_dystrophic_cardiac_calcinosis	0.58647425
98	MP0004197_abnormal_fetal_growth/weight/	0.58429243
99	MP0000358_abnormal_cell_content/	0.57979182
100	MP0003806_abnormal_nucleotide_metabolis	0.56942201

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic islet-cell hyperplasia (HP:0004510)	4.45717749
2	Hip dysplasia (HP:0001385)	4.23314734
3	Abnormality of the pancreatic islet cells (HP:0006476)	3.76722136
4	Abnormality of endocrine pancreas physiology (HP:0012093)	3.76722136
5	Large for gestational age (HP:0001520)	3.35727410
6	Thyroiditis (HP:0100646)	3.33670365
7	Volvulus (HP:0002580)	3.21784093
8	Type II lissencephaly (HP:0007260)	3.17951994
9	Genetic anticipation (HP:0003743)	3.13586468
10	Abnormal hair whorl (HP:0010721)	3.07622278
11	Hyperinsulinemic hypoglycemia (HP:0000825)	3.07448282
12	Broad-based gait (HP:0002136)	3.06233050
13	Calf muscle hypertrophy (HP:0008981)	3.04644107
14	Fair hair (HP:0002286)	3.01942096
15	Hyperglycemia (HP:0003074)	2.92898840
16	Cerebellar dysplasia (HP:0007033)	2.85232800
17	True hermaphroditism (HP:0010459)	2.77895835
18	Prominent metopic ridge (HP:0005487)	2.74921006
19	Decreased muscle mass (HP:0003199)	2.72580091
20	Pancreatic cysts (HP:0001737)	2.69722966
21	Insulin-resistant diabetes mellitus (HP:0000831)	2.65358263
22	Hypothermia (HP:0002045)	2.63772883
23	Spondylolisthesis (HP:0003302)	2.63382167
24	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.61142109
25	Muscle hypertrophy of the lower extremities (HP:0008968)	2.57944577
26	Molar tooth sign on MRI (HP:0002419)	2.56860003
27	Abnormality of midbrain morphology (HP:0002418)	2.56860003
28	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.53363687
29	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.53363687
30	Abnormality of the renal cortex (HP:0011035)	2.52753341
31	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.52312471
32	Abnormality of the metopic suture (HP:0005556)	2.51128681
33	Papillary thyroid carcinoma (HP:0002895)	2.50195004
34	Nephronophthisis (HP:0000090)	2.48217483
35	Abnormality of chromosome stability (HP:0003220)	2.46414468
36	Neoplasm of the adrenal cortex (HP:0100641)	2.43290515
37	Pancreatic fibrosis (HP:0100732)	2.42108327
38	Agitation (HP:0000713)	2.40178591
39	Ketoacidosis (HP:0001993)	2.37704402
40	Submucous cleft hard palate (HP:0000176)	2.37014854
41	Colon cancer (HP:0003003)	2.35109038
42	Febrile seizures (HP:0002373)	2.34411476
43	Inappropriate behavior (HP:0000719)	2.33014623
44	Cystic hygroma (HP:0000476)	2.32783654
45	Abnormality of the renal medulla (HP:0100957)	2.30013365
46	Abolished electroretinogram (ERG) (HP:0000550)	2.30003427
47	Renal cortical cysts (HP:0000803)	2.29982417
48	Pelvic girdle muscle weakness (HP:0003749)	2.28810768
49	Gaze-evoked nystagmus (HP:0000640)	2.27989462
50	Thoracolumbar scoliosis (HP:0002944)	2.27653280
51	Absent speech (HP:0001344)	2.23714777
52	Protruding tongue (HP:0010808)	2.23305769
53	Abnormal biliary tract morphology (HP:0012440)	2.16052982
54	Abnormality of the hip-girdle musculature (HP:0001445)	2.15466293
55	Abnormality of the musculature of the pelvis (HP:0001469)	2.15466293
56	Hyperventilation (HP:0002883)	2.14124089
57	Severe combined immunodeficiency (HP:0004430)	2.11180501
58	Chronic hepatic failure (HP:0100626)	2.09126947
59	Biliary tract neoplasm (HP:0100574)	2.08060166
60	Short tibia (HP:0005736)	2.06342533
61	Drooling (HP:0002307)	2.06317486
62	Increased corneal curvature (HP:0100692)	2.04238479
63	Keratoconus (HP:0000563)	2.04238479
64	Generalized hypopigmentation of hair (HP:0011358)	2.01429699
65	Abnormality of the frontal sinuses (HP:0002687)	2.00437891
66	Type 2 muscle fiber atrophy (HP:0003554)	1.99853586
67	Sparse lateral eyebrow (HP:0005338)	1.98163256
68	Absent eyebrow (HP:0002223)	1.96574020
69	Medial flaring of the eyebrow (HP:0010747)	1.95699228
70	Abnormality of the labia minora (HP:0012880)	1.93288996
71	Increased density of long bones (HP:0006392)	1.92518866
72	Attenuation of retinal blood vessels (HP:0007843)	1.88019224
73	Tubulointerstitial nephritis (HP:0001970)	1.87561336
74	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.84255211
75	Excessive salivation (HP:0003781)	1.83922470
76	Atonic seizures (HP:0010819)	1.83588092
77	Methylmalonic acidemia (HP:0002912)	1.80895258
78	Sloping forehead (HP:0000340)	1.79032153
79	Narrow forehead (HP:0000341)	1.78693098
80	Hypoglycemic coma (HP:0001325)	1.78674261
81	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.77934799
82	Abnormality of the ischium (HP:0003174)	1.77620223
83	Widely spaced teeth (HP:0000687)	1.76873683
84	Progressive cerebellar ataxia (HP:0002073)	1.76833795
85	Hypoplastic ischia (HP:0003175)	1.75575086
86	Combined immunodeficiency (HP:0005387)	1.75474549
87	Abnormality of the pons (HP:0007361)	1.75391826
88	Hypoplasia of the pons (HP:0012110)	1.73908508
89	Thin upper lip vermilion (HP:0000219)	1.73044879
90	Infantile muscular hypotonia (HP:0008947)	1.71446643
91	Intestinal atresia (HP:0011100)	1.70793995
92	Shoulder girdle muscle weakness (HP:0003547)	1.70366552
93	Neoplasm of the small intestine (HP:0100833)	1.67499201
94	Dandy-Walker malformation (HP:0001305)	1.67117883
95	Cystic liver disease (HP:0006706)	1.66590529
96	Difficulty running (HP:0009046)	1.66435572
97	Lissencephaly (HP:0001339)	1.64451182
98	Hypoproteinemia (HP:0003075)	1.64145812
99	Macroglossia (HP:0000158)	1.63737477
100	Hypochromic microcytic anemia (HP:0004840)	1.61232269

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.58758590
2	NEK1	3.87680425
3	AKT3	3.26915415
4	MKNK2	3.09406119
5	MUSK	2.65364071
6	NUAK1	2.55451165
7	BMPR1B	2.52076277
8	BUB1	2.26325275
9	MAPK13	2.24811485
10	MAP3K4	2.16931427
11	DYRK3	2.04542663
12	BRSK2	1.97442638
13	ERBB3	1.83592337
14	WEE1	1.77822446
15	CCNB1	1.72092913
16	SGK2	1.61171291
17	EIF2AK3	1.58237822
18	TGFBR2	1.56059813
19	MAP3K12	1.47209382
20	MKNK1	1.40181440
21	CDK8	1.35565919
22	ACVR1B	1.33221167
23	TNIK	1.32015016
24	TRIM28	1.30586410
25	ZAK	1.27837052
26	STK3	1.27115844
27	PLK3	1.24543860
28	RPS6KA4	1.24373046
29	TAOK3	1.22710664
30	PLK2	1.18219947
31	CSNK1G1	1.14561424
32	TAF1	1.13597199
33	MARK1	1.12885100
34	FLT3	1.10219176
35	STK38L	1.09020131
36	BCR	1.05775313
37	LATS1	1.04276213
38	PKN2	1.03071677
39	MAP2K7	1.02140119
40	CAMKK2	1.01687095
41	CSNK1G2	0.98570483
42	SGK3	0.98254297
43	NLK	0.95971661
44	UHMK1	0.93327222
45	CASK	0.92590188
46	PRKCE	0.90095899
47	VRK1	0.87027619
48	SGK494	0.83657629
49	SGK223	0.83657629
50	TRPM7	0.83224635
51	PLK4	0.83135548
52	GRK1	0.82785210
53	WNK3	0.81391897
54	TEC	0.81159900
55	MAP4K2	0.79906878
56	VRK2	0.79130394
57	ERBB2	0.75575360
58	FER	0.74507345
59	PAK3	0.71777947
60	ROCK1	0.70726229
61	OXSR1	0.69600027
62	DYRK1A	0.66705957
63	CSNK1A1L	0.64855112
64	STK24	0.62243307
65	MYLK	0.61400987
66	CAMK2D	0.61357037
67	CAMK1D	0.60832874
68	PTK2B	0.60026319
69	PINK1	0.59981527
70	TGFBR1	0.59260871
71	PLK1	0.59111699
72	MAP3K7	0.58316187
73	TIE1	0.58284882
74	CSNK1G3	0.57879494
75	CAMK2B	0.57373388
76	GRK5	0.57289543
77	STK39	0.56401481
78	ADRBK2	0.56235558
79	EIF2AK2	0.52246814
80	TXK	0.52194328
81	MELK	0.51802849
82	MST4	0.50911316
83	CAMK4	0.50694067
84	INSRR	0.48949714
85	DAPK2	0.48900080
86	IRAK1	0.46752287
87	OBSCN	0.46575666
88	ATR	0.45961146
89	PKN1	0.40106564
90	STK11	0.39501411
91	IKBKE	0.37839906
92	CHUK	0.37163901
93	ATM	0.36669715
94	CAMK2A	0.36108997
95	SRPK1	0.34579000
96	MARK3	0.34025446
97	GSK3A	0.33981642
98	MAP3K9	0.33442363
99	PRKG1	0.33367654
100	PIK3CG	0.33159016

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	4.59756255
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	3.19472645
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.84160969
4	Protein export_Homo sapiens_hsa03060	2.60420045
5	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.51050139
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.38441581
7	RNA degradation_Homo sapiens_hsa03018	2.37269402
8	Circadian rhythm_Homo sapiens_hsa04710	2.34413108
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.25229149
10	Nicotine addiction_Homo sapiens_hsa05033	2.19412039
11	Regulation of autophagy_Homo sapiens_hsa04140	2.06309876
12	Propanoate metabolism_Homo sapiens_hsa00640	1.85058732
13	Basal transcription factors_Homo sapiens_hsa03022	1.82861648
14	Phototransduction_Homo sapiens_hsa04744	1.82441695
15	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.76535613
16	Sulfur metabolism_Homo sapiens_hsa00920	1.57874128
17	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.52866130
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.50544417
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.49744421
20	Homologous recombination_Homo sapiens_hsa03440	1.48869215
21	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.48388418
22	Caffeine metabolism_Homo sapiens_hsa00232	1.46931011
23	Glutamatergic synapse_Homo sapiens_hsa04724	1.46685868
24	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.40495805
25	One carbon pool by folate_Homo sapiens_hsa00670	1.37060920
26	Butanoate metabolism_Homo sapiens_hsa00650	1.36342748
27	RNA polymerase_Homo sapiens_hsa03020	1.31867228
28	Taste transduction_Homo sapiens_hsa04742	1.31327352
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.29193174
30	Oocyte meiosis_Homo sapiens_hsa04114	1.24225497
31	Renin secretion_Homo sapiens_hsa04924	1.23605381
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.23542054
33	Amphetamine addiction_Homo sapiens_hsa05031	1.21713611
34	RNA transport_Homo sapiens_hsa03013	1.18524048
35	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.18166198
36	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.16135439
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.14798421
38	Type II diabetes mellitus_Homo sapiens_hsa04930	1.13267770
39	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11370895
40	Insulin secretion_Homo sapiens_hsa04911	1.07833217
41	Olfactory transduction_Homo sapiens_hsa04740	1.04803263
42	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.04278355
43	ABC transporters_Homo sapiens_hsa02010	1.01200702
44	Nitrogen metabolism_Homo sapiens_hsa00910	1.00215577
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96011355
46	Linoleic acid metabolism_Homo sapiens_hsa00591	0.94200877
47	Cell cycle_Homo sapiens_hsa04110	0.93163488
48	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.91254928
49	Retinol metabolism_Homo sapiens_hsa00830	0.87716111
50	Tryptophan metabolism_Homo sapiens_hsa00380	0.83406990
51	Peroxisome_Homo sapiens_hsa04146	0.82900960
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.81987567
53	Circadian entrainment_Homo sapiens_hsa04713	0.81839310
54	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.81693438
55	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.77797331
56	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.77792116
57	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74808976
58	Proteasome_Homo sapiens_hsa03050	0.67354134
59	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.64573395
60	Hippo signaling pathway_Homo sapiens_hsa04390	0.60941765
61	Sphingolipid metabolism_Homo sapiens_hsa00600	0.60178445
62	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.60047032
63	Serotonergic synapse_Homo sapiens_hsa04726	0.56690837
64	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56186203
65	Melanoma_Homo sapiens_hsa05218	0.55719146
66	Steroid biosynthesis_Homo sapiens_hsa00100	0.54332760
67	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.53577277
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52443734
69	Huntingtons disease_Homo sapiens_hsa05016	0.51965583
70	Cocaine addiction_Homo sapiens_hsa05030	0.51852512
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.51568785
72	Lysine degradation_Homo sapiens_hsa00310	0.50252897
73	Wnt signaling pathway_Homo sapiens_hsa04310	0.49518118
74	GABAergic synapse_Homo sapiens_hsa04727	0.47428664
75	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.47393589
76	Long-term depression_Homo sapiens_hsa04730	0.46553593
77	Fatty acid degradation_Homo sapiens_hsa00071	0.46514217
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.45427788
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.45237730
80	p53 signaling pathway_Homo sapiens_hsa04115	0.44740582
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.44708149
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42180568
83	Ras signaling pathway_Homo sapiens_hsa04014	0.41325943
84	Axon guidance_Homo sapiens_hsa04360	0.40829706
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40486678
86	FoxO signaling pathway_Homo sapiens_hsa04068	0.39351278
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38846863
88	Adherens junction_Homo sapiens_hsa04520	0.38616066
89	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.38041715
90	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37873424
91	Bile secretion_Homo sapiens_hsa04976	0.36958649
92	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.36750612
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36202965
94	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.35828701
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.35321231
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.34084425
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.34045083
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.33665301
99	Long-term potentiation_Homo sapiens_hsa04720	0.33620277
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.33454113

TATDN1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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