TATDN2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of T cell receptor signaling pathway (GO:0050860)8.52527539
2protein-chromophore linkage (GO:0018298)7.35784929
3relaxation of smooth muscle (GO:0044557)7.25439083
4multicellular organismal reproductive behavior (GO:0033057)6.96110422
5negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)6.78299508
6phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)6.71282524
7negative regulation of myotube differentiation (GO:0010832)6.21850752
8adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.55164931
9meiotic chromosome segregation (GO:0045132)5.08986390
10transmission of nerve impulse (GO:0019226)5.05106639
11regulation of T cell receptor signaling pathway (GO:0050856)4.93349841
12positive regulation of extracellular matrix organization (GO:1903055)4.74445500
13long term synaptic depression (GO:0060292)4.72109375
14viral entry into host cell (GO:0046718)4.69858871
15multi-organism reproductive behavior (GO:0044705)4.63279260
16fusion of sperm to egg plasma membrane (GO:0007342)4.60908597
17positive regulation of interleukin-2 production (GO:0032743)4.56515015
18reproductive behavior (GO:0019098)4.55368150
19synaptic transmission, dopaminergic (GO:0001963)4.19014922
20phosphatidylinositol acyl-chain remodeling (GO:0036149)4.07297282
21negative regulation of smooth muscle contraction (GO:0045986)4.00056243
22L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.95394432
23nitric oxide mediated signal transduction (GO:0007263)3.83499945
24regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.80990421
25regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)3.75275675
26dopamine transport (GO:0015872)3.74840644
27negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.73736961
28positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.72355547
29proline biosynthetic process (GO:0006561)3.70298745
30regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.68829093
31nephron tubule formation (GO:0072079)3.68030623
32cardiolipin metabolic process (GO:0032048)3.64220499
33NLS-bearing protein import into nucleus (GO:0006607)3.59752974
34positive regulation of cGMP biosynthetic process (GO:0030828)3.43210795
35entry into host cell (GO:0030260)3.41847425
36movement in environment of other organism involved in symbiotic interaction (GO:0052192)3.41847425
37entry into cell of other organism involved in symbiotic interaction (GO:0051806)3.41847425
38entry into host (GO:0044409)3.41847425
39entry into other organism involved in symbiotic interaction (GO:0051828)3.41847425
40movement in host environment (GO:0052126)3.41847425
41plasma membrane fusion (GO:0045026)3.40882729
42hydrogen peroxide catabolic process (GO:0042744)3.40645111
43cytoplasmic microtubule organization (GO:0031122)3.32231701
44response to host immune response (GO:0052572)3.31358027
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.31358027
46L-methionine salvage (GO:0071267)3.28122461
47L-methionine biosynthetic process (GO:0071265)3.28122461
48amino acid salvage (GO:0043102)3.28122461
49regulation of DNA-templated transcription, initiation (GO:2000142)3.25874646
50regulation of cGMP biosynthetic process (GO:0030826)3.20210222
51histone H4 deacetylation (GO:0070933)3.18590083
52methionine biosynthetic process (GO:0009086)3.16211662
53response to host (GO:0075136)3.14001181
54response to host defenses (GO:0052200)3.14001181
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14001181
56negative regulation of muscle contraction (GO:0045932)3.11905999
57tachykinin receptor signaling pathway (GO:0007217)3.07411623
58regulation of metalloenzyme activity (GO:0048552)3.05791658
59proline metabolic process (GO:0006560)3.03056775
60indolalkylamine metabolic process (GO:0006586)3.02778962
61cGMP biosynthetic process (GO:0006182)3.02717087
62monoamine transport (GO:0015844)3.02249793
63relaxation of muscle (GO:0090075)3.00470095
64angiogenesis involved in wound healing (GO:0060055)2.98741011
65multicellular organism reproduction (GO:0032504)2.98318065
66thyroid gland development (GO:0030878)2.97911734
67regulation of platelet aggregation (GO:0090330)2.95550596
68thrombin receptor signaling pathway (GO:0070493)2.94471625
69pyrimidine-containing compound salvage (GO:0008655)2.94385087
70pyrimidine nucleoside salvage (GO:0043097)2.94385087
71regulation of megakaryocyte differentiation (GO:0045652)2.92904641
72regulation of interleukin-2 production (GO:0032663)2.92375335
73intestinal epithelial cell development (GO:0060576)2.92052712
74positive regulation of male gonad development (GO:2000020)2.91469853
75lung epithelial cell differentiation (GO:0060487)2.87531578
76positive regulation of cGMP metabolic process (GO:0030825)2.87438429
77regulation of rhodopsin mediated signaling pathway (GO:0022400)2.86951614
78maternal behavior (GO:0042711)2.84114492
79otic vesicle formation (GO:0030916)2.82249078
80macroautophagy (GO:0016236)2.81994310
81regulation of lipoprotein metabolic process (GO:0050746)2.80480878
82sensory perception of chemical stimulus (GO:0007606)2.80162057
83regulation of hydrogen peroxide metabolic process (GO:0010310)2.78061245
84regulation of cGMP metabolic process (GO:0030823)2.74193324
85ectoderm development (GO:0007398)2.72690573
86glomerular visceral epithelial cell development (GO:0072015)2.72609870
87phenol-containing compound catabolic process (GO:0019336)2.72167506
88neurotransmitter catabolic process (GO:0042135)2.71580992
89lung cell differentiation (GO:0060479)2.69303313
90S-adenosylmethionine metabolic process (GO:0046500)2.68600994
91rhodopsin mediated signaling pathway (GO:0016056)2.68065180
92methionine metabolic process (GO:0006555)2.66586333
93pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.64559127
94UMP biosynthetic process (GO:0006222)2.64559127
95pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.64559127
96UMP metabolic process (GO:0046049)2.64559127
97positive regulation of cAMP-mediated signaling (GO:0043950)2.58817013
98positive regulation of myotube differentiation (GO:0010831)2.58173945
99regulation of female receptivity (GO:0045924)17.6355459
100female mating behavior (GO:0060180)15.4261220

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.86206980
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.21726439
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.69403397
4SCL_19346495_ChIP-Seq_HPC-7_Human3.27614046
5SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.97705674
6LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.68571218
7GBX2_23144817_ChIP-Seq_PC3_Human2.61897804
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.39915925
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.19753951
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.15467821
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13853643
12GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.03826597
13POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.85456718
14TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85456718
15DROSHA_22980978_ChIP-Seq_HELA_Human1.83227509
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78346607
17VDR_22108803_ChIP-Seq_LS180_Human1.72067783
18P300_19829295_ChIP-Seq_ESCs_Human1.69278046
19UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67254564
20VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.66962893
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.64159364
22GATA3_21878914_ChIP-Seq_MCF-7_Human1.63395089
23GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.63205706
24ER_23166858_ChIP-Seq_MCF-7_Human1.60864461
25TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.60696422
26FOXA1_21572438_ChIP-Seq_LNCaP_Human1.59778177
27PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.49801064
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47368917
29TCF4_23295773_ChIP-Seq_U87_Human1.43927131
30DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43645857
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41413267
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40204610
33LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38025213
34ZNF274_21170338_ChIP-Seq_K562_Hela1.36342691
35SMAD4_21799915_ChIP-Seq_A2780_Human1.23378210
36P53_21459846_ChIP-Seq_SAOS-2_Human1.23113580
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22849547
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17388163
39STAT3_23295773_ChIP-Seq_U87_Human1.16862688
40GATA3_26560356_Chip-Seq_TH2_Human1.15966333
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14586193
42FLI1_21867929_ChIP-Seq_TH2_Mouse1.13847615
43E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13735869
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.13575204
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13560187
46LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.12200001
47FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11433876
48ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10878808
49BCAT_22108803_ChIP-Seq_LS180_Human1.09734818
50BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.09531875
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08961580
52LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07724247
53FUS_26573619_Chip-Seq_HEK293_Human1.07445322
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.07433947
55TCF4_22108803_ChIP-Seq_LS180_Human1.07433275
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.07305717
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.07230863
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06517810
59TP53_22573176_ChIP-Seq_HFKS_Human1.05730726
60GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.05721163
61NANOG_19829295_ChIP-Seq_ESCs_Human1.05467590
62SOX2_19829295_ChIP-Seq_ESCs_Human1.05467590
63TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04036506
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03692577
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03692577
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02893554
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02612301
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02419771
69EWS_26573619_Chip-Seq_HEK293_Human1.02059472
70TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01792319
71SMAD4_21741376_ChIP-Seq_HESCs_Human1.01308929
72HOXB7_26014856_ChIP-Seq_BT474_Human1.00840025
73TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00495956
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00486611
75SMAD3_21741376_ChIP-Seq_HESCs_Human0.99857317
76TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99432309
77IGF1R_20145208_ChIP-Seq_DFB_Human0.99403556
78FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99281682
79TAF15_26573619_Chip-Seq_HEK293_Human0.98939832
80RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98566299
81ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97995329
82HTT_18923047_ChIP-ChIP_STHdh_Human0.96826961
83KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96071197
84GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.95783819
85EP300_21415370_ChIP-Seq_HL-1_Mouse0.95444528
86GATA4_25053715_ChIP-Seq_YYC3_Human0.94540820
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94261987
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94052303
89AR_20517297_ChIP-Seq_VCAP_Human0.92617018
90CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92247331
91GATA3_21867929_ChIP-Seq_TH1_Mouse0.92141834
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91565677
93SMRT_27268052_Chip-Seq_Bcells_Human0.90023615
94CEBPB_22108803_ChIP-Seq_LS180_Human0.88274974
95OCT1_27270436_Chip-Seq_PROSTATE_Human0.87055130
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.86971276
97FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86664054
98FOXA1_25329375_ChIP-Seq_VCAP_Human0.86664054
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85864115
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.85851871

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color7.86611106
2MP0009780_abnormal_chondrocyte_physiolo7.04299124
3MP0002132_abnormal_respiratory_system5.88833258
4MP0000372_irregular_coat_pigmentation4.37332005
5MP0002163_abnormal_gland_morphology3.89152956
6MP0005379_endocrine/exocrine_gland_phen3.53825213
7MP0003879_abnormal_hair_cell3.28404878
8MP0005464_abnormal_platelet_physiology3.27679282
9MP0008004_abnormal_stomach_pH2.76875354
10MP0006276_abnormal_autonomic_nervous2.56351230
11MP0005187_abnormal_penis_morphology2.49356028
12MP0004381_abnormal_hair_follicle2.44005263
13MP0004885_abnormal_endolymph2.26887817
14MP0004130_abnormal_muscle_cell2.18751132
15MP0002653_abnormal_ependyma_morphology2.13479895
16MP0002909_abnormal_adrenal_gland1.95847801
17MP0002102_abnormal_ear_morphology1.92953919
18MP0005645_abnormal_hypothalamus_physiol1.83325266
19MP0008775_abnormal_heart_ventricle1.82325265
20MP0002736_abnormal_nociception_after1.78032969
21MP0003638_abnormal_response/metabolism_1.73596386
22MP0001968_abnormal_touch/_nociception1.68455633
23MP0001851_eye_inflammation1.66799907
24MP0000230_abnormal_systemic_arterial1.65700258
25MP0005410_abnormal_fertilization1.63611805
26MP0010030_abnormal_orbit_morphology1.59554756
27MP0005360_urolithiasis1.55194807
28MP0008872_abnormal_physiological_respon1.46211768
29MP0008875_abnormal_xenobiotic_pharmacok1.44579461
30MP0000681_abnormal_thyroid_gland1.44134039
31MP0003866_abnormal_defecation1.38126984
32MP0003724_increased_susceptibility_to1.35733968
33MP0001533_abnormal_skeleton_physiology1.31403261
34MP0000383_abnormal_hair_follicle1.25173076
35MP0002090_abnormal_vision1.22528798
36MP0001664_abnormal_digestion1.13926659
37MP0001348_abnormal_lacrimal_gland1.11764066
38MP0003045_fibrosis1.10813339
39MP0003436_decreased_susceptibility_to1.10336877
40MP0003938_abnormal_ear_development1.09459832
41MP0009697_abnormal_copulation1.03198878
42MP0003567_abnormal_fetal_cardiomyocyte1.02370768
43MP0005551_abnormal_eye_electrophysiolog0.97197534
44MP0005646_abnormal_pituitary_gland0.96788995
45MP0000647_abnormal_sebaceous_gland0.90217827
46MP0001501_abnormal_sleep_pattern0.88282481
47MP0002138_abnormal_hepatobiliary_system0.88084638
48MP0005390_skeleton_phenotype0.87513291
49MP0005167_abnormal_blood-brain_barrier0.87488641
50MP0000465_gastrointestinal_hemorrhage0.86730827
51MP0005397_hematopoietic_system_phenotyp0.85895292
52MP0001545_abnormal_hematopoietic_system0.85895292
53MP0002998_abnormal_bone_remodeling0.85210367
54MP0003119_abnormal_digestive_system0.84400456
55MP0000049_abnormal_middle_ear0.83585410
56MP0000613_abnormal_salivary_gland0.83579125
57MP0002249_abnormal_larynx_morphology0.81307307
58MP0004085_abnormal_heartbeat0.81282210
59MP0005670_abnormal_white_adipose0.79154072
60MP0003252_abnormal_bile_duct0.78490584
61MP0002168_other_aberrant_phenotype0.75865693
62MP0006035_abnormal_mitochondrial_morpho0.75201981
63MP0009765_abnormal_xenobiotic_induced0.74439638
64MP0005535_abnormal_body_temperature0.73998943
65MP0001485_abnormal_pinna_reflex0.72783299
66MP0009278_abnormal_bone_marrow0.72567251
67MP0001756_abnormal_urination0.68141147
68MP0006036_abnormal_mitochondrial_physio0.67072409
69MP0000631_abnormal_neuroendocrine_gland0.66281082
70MP0002282_abnormal_trachea_morphology0.66166510
71MP0010329_abnormal_lipoprotein_level0.63240066
72MP0005395_other_phenotype0.60955302
73MP0003718_maternal_effect0.59922572
74MP0001963_abnormal_hearing_physiology0.57274459
75MP0002876_abnormal_thyroid_physiology0.54408181
76MP0003646_muscle_fatigue0.53441725
77MP0010678_abnormal_skin_adnexa0.52193623
78MP0001544_abnormal_cardiovascular_syste0.51724142
79MP0005385_cardiovascular_system_phenoty0.51724142
80MP0002572_abnormal_emotion/affect_behav0.50877341
81MP0000685_abnormal_immune_system0.50255821
82MP0006072_abnormal_retinal_apoptosis0.49797595
83MP0005377_hearing/vestibular/ear_phenot0.49109734
84MP0003878_abnormal_ear_physiology0.49109734
85MP0002972_abnormal_cardiac_muscle0.49102887
86MP0003137_abnormal_impulse_conducting0.48727963
87MP0002148_abnormal_hypersensitivity_rea0.48533640
88MP0001502_abnormal_circadian_rhythm0.47970417
89MP0008874_decreased_physiological_sensi0.47822783
90MP0001486_abnormal_startle_reflex0.45695680
91MP0009333_abnormal_splenocyte_physiolog0.45434128
92MP0009046_muscle_twitch0.44915123
93MP0003122_maternal_imprinting0.44508827
94MP0002118_abnormal_lipid_homeostasis0.44389917
95MP0005620_abnormal_muscle_contractility0.44339235
96MP0010155_abnormal_intestine_physiology0.43124416
97MP0009763_increased_sensitivity_to0.42770598
98MP0000343_altered_response_to0.41736411
99MP0002733_abnormal_thermal_nociception0.41526226
100MP0002234_abnormal_pharynx_morphology0.41045074

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)6.19794615
2Premature skin wrinkling (HP:0100678)5.66885446
3Short chin (HP:0000331)5.03572390
4Severe visual impairment (HP:0001141)5.01850272
5Conical tooth (HP:0000698)4.90840610
611 pairs of ribs (HP:0000878)4.68027578
7Prolonged bleeding time (HP:0003010)4.62309806
8Increased connective tissue (HP:0009025)4.47530197
9Abnormal rod and cone electroretinograms (HP:0008323)4.46500144
10Menorrhagia (HP:0000132)4.45868966
11Rimmed vacuoles (HP:0003805)4.29897492
12Centrally nucleated skeletal muscle fibers (HP:0003687)4.17165606
13Congenital stationary night blindness (HP:0007642)3.95787222
14Keratoconjunctivitis sicca (HP:0001097)3.94314177
15Keratoconjunctivitis (HP:0001096)3.86667580
16Shoulder girdle muscle weakness (HP:0003547)3.86502876
17Increased mean platelet volume (HP:0011877)3.83157052
18Absent eyebrow (HP:0002223)3.71778771
19Pelvic girdle muscle weakness (HP:0003749)3.71622178
20Anhidrosis (HP:0000970)3.71593028
21Mesangial abnormality (HP:0001966)3.67534308
22Abnormal platelet volume (HP:0011876)3.58277133
23Hemiparesis (HP:0001269)3.48903940
24Hypoproteinemia (HP:0003075)3.45716964
25Petechiae (HP:0000967)3.37186432
26Epistaxis (HP:0000421)3.25917110
27Neonatal respiratory distress (HP:0002643)3.22329302
28Attenuation of retinal blood vessels (HP:0007843)3.18740990
29Hyperthyroidism (HP:0000836)3.16344897
30Prominent supraorbital ridges (HP:0000336)3.14964165
31Tubular atrophy (HP:0000092)3.11246572
32Abnormality of the hip-girdle musculature (HP:0001445)3.10800862
33Abnormality of the musculature of the pelvis (HP:0001469)3.10800862
34Purpura (HP:0000979)3.01896247
35Cerebellar dysplasia (HP:0007033)3.00188581
36Abnormality of the dental pulp (HP:0006479)2.98941709
37Hypoplasia of the fovea (HP:0007750)2.93764713
38Aplasia/Hypoplasia of the fovea (HP:0008060)2.93764713
39Tinnitus (HP:0000360)2.91500231
40Pigmentary retinal degeneration (HP:0001146)2.85166949
41Relative macrocephaly (HP:0004482)2.74399601
42Abnormal pupillary function (HP:0007686)2.71682413
43Gingival bleeding (HP:0000225)2.70816005
44Brittle hair (HP:0002299)2.69965962
45Type II lissencephaly (HP:0007260)2.68028811
46Abnormality of transition element cation homeostasis (HP:0011030)2.66045406
47Abnormality of permanent molar morphology (HP:0011071)2.64899558
48Abnormality of the dental root (HP:0006486)2.64899558
49Taurodontia (HP:0000679)2.64899558
50Hypoplastic nipples (HP:0002557)2.64230516
51Papillary thyroid carcinoma (HP:0002895)2.61074956
52Congenital hip dislocation (HP:0001374)2.56759698
53Type I diabetes mellitus (HP:0100651)2.55102064
54Hypoplastic iliac wings (HP:0002866)2.51071030
55Hypotrichosis (HP:0001006)2.49819622
56Abnormality of the fovea (HP:0000493)2.49776425
57Abnormality of molar (HP:0011077)2.48103762
58Abnormality of molar morphology (HP:0011070)2.48103762
59Autoimmune hemolytic anemia (HP:0001890)2.45761467
60Spinal rigidity (HP:0003306)2.45482381
61Soft skin (HP:0000977)2.45193149
62Decreased central vision (HP:0007663)2.42538995
63Spontaneous hematomas (HP:0007420)2.40996504
64Abnormality of B cell number (HP:0010975)2.40547555
65Abnormal sex determination (HP:0012244)2.40292288
66Sex reversal (HP:0012245)2.40292288
67True hermaphroditism (HP:0010459)2.38657373
68Gaze-evoked nystagmus (HP:0000640)2.27423404
69Neonatal short-limb short stature (HP:0008921)2.27042411
70Oligodontia (HP:0000677)2.25120365
71Gastrointestinal dysmotility (HP:0002579)2.24430504
72Abnormality of the 4th metacarpal (HP:0010012)2.21911713
73Metaphyseal cupping (HP:0003021)2.17168739
74Central scotoma (HP:0000603)2.16642004
75Dysphonia (HP:0001618)2.14564078
76Bilateral sensorineural hearing impairment (HP:0008619)2.13297627
77Thyroid-stimulating hormone excess (HP:0002925)2.09273479
78Abnormality of macular pigmentation (HP:0008002)2.07042674
79Optic nerve hypoplasia (HP:0000609)2.06352139
80Erythroderma (HP:0001019)2.05597314
81Abnormal tarsal ossification (HP:0008369)2.03545676
82Keratitis (HP:0000491)2.02335558
83Abnormal platelet function (HP:0011869)2.01671848
84Impaired platelet aggregation (HP:0003540)2.01671848
85Bony spicule pigmentary retinopathy (HP:0007737)1.90212870
86Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88976339
87Hyperventilation (HP:0002883)1.87518606
88Absent hair (HP:0002298)1.87258723
89Abnormality of iron homeostasis (HP:0011031)1.87018790
90Lip pit (HP:0100267)1.85380446
91Sparse eyelashes (HP:0000653)1.85026397
92Pustule (HP:0200039)1.83982220
93Missing ribs (HP:0000921)1.82632209
94Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82540881
95Scapular winging (HP:0003691)1.81994482
96Focal seizures (HP:0007359)1.81590430
97Severe Myopia (HP:0011003)1.80114733
98Hyperlipoproteinemia (HP:0010980)1.79834406
99Respiratory difficulties (HP:0002880)1.78260430
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76049100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.22515298
2MST44.42972961
3CDK123.88082131
4ADRBK23.60863958
5MAP3K103.06089967
6KIT3.03073300
7IRAK32.97188707
8PINK12.49117678
9DAPK22.36214487
10BUB12.14843634
11STK381.91816124
12JAK31.90769945
13MAP2K71.78412383
14ERBB21.75899365
15TEC1.61866315
16MAPKAPK31.56126449
17SYK1.55253304
18TXK1.54380128
19BMX1.49327962
20ADRBK11.34672481
21TAF11.34094771
22PTK2B1.33757413
23PBK1.32217968
24MYLK1.30742466
25NUAK11.30695156
26MAP4K11.26649499
27FGR1.16711563
28PAK31.15966981
29MAP3K71.15804815
30ACVR1B1.13701599
31DAPK11.13220600
32PLK21.10945106
33EPHA21.03250993
34CAMKK20.97911736
35PRKCQ0.97610236
36CDK70.97037884
37TNK20.93691644
38GRK10.93523048
39PKN10.92195508
40CSF1R0.91870493
41PIK3CG0.91190792
42DAPK30.87324397
43PRKACG0.81284312
44AKT20.80837895
45LATS20.78793980
46ARAF0.77925802
47PRKCE0.77880214
48CAMKK10.77266946
49STK30.75383486
50ROCK10.74234502
51BTK0.71863744
52CAMK2A0.70323889
53TAOK30.69006362
54GRK50.67646119
55HCK0.67029482
56TBK10.61961784
57EGFR0.61560076
58IKBKB0.61461275
59MKNK20.61349444
60STK100.60991639
61PRKD10.59179111
62WNK30.58208588
63LCK0.58122519
64PRKCA0.57110299
65MATK0.55790809
66PIM20.55758421
67LATS10.55163136
68DYRK20.52670106
69PRKCD0.52444849
70LMTK20.52334816
71PRKAA20.52198730
72CAMK2D0.52172888
73KDR0.50931256
74VRK20.50680484
75PRKCI0.50298406
76HIPK20.50144270
77PRKCG0.49899257
78LRRK20.49897665
79CDK140.49871544
80FES0.49151557
81ZAK0.49139925
82LYN0.48917944
83MAP3K10.48770453
84JAK10.47995089
85PRKG20.47649046
86CAMK10.47244443
87TRPM70.47023059
88FER0.47009577
89CDK50.46022820
90AKT10.44163705
91PRKCB0.43625707
92PRKD20.42704367
93ITK0.42482742
94PRKACA0.41589811
95BRSK10.38132937
96GRK60.37220389
97MELK0.36959126
98VRK10.35928005
99MAPK30.35270561
100CDK150.34762898

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.72576033
2Tryptophan metabolism_Homo sapiens_hsa003803.55301836
3Platelet activation_Homo sapiens_hsa046112.96261901
4Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.80214579
5Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.76613708
6Salivary secretion_Homo sapiens_hsa049702.45880901
7Olfactory transduction_Homo sapiens_hsa047402.31302347
8Linoleic acid metabolism_Homo sapiens_hsa005912.20832170
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.17662568
10Pentose phosphate pathway_Homo sapiens_hsa000302.08945187
11Arachidonic acid metabolism_Homo sapiens_hsa005902.00096556
12Glycerophospholipid metabolism_Homo sapiens_hsa005641.96658989
13Long-term depression_Homo sapiens_hsa047301.96208788
14Circadian entrainment_Homo sapiens_hsa047131.90325199
15Renin secretion_Homo sapiens_hsa049241.85275132
16Vascular smooth muscle contraction_Homo sapiens_hsa042701.77143993
17Nicotine addiction_Homo sapiens_hsa050331.70930884
18Caffeine metabolism_Homo sapiens_hsa002321.70639738
19Arginine and proline metabolism_Homo sapiens_hsa003301.65772487
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.61455218
21Calcium signaling pathway_Homo sapiens_hsa040201.60333493
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59873672
23Nitrogen metabolism_Homo sapiens_hsa009101.58775385
24Serotonergic synapse_Homo sapiens_hsa047261.56459627
25Glycerolipid metabolism_Homo sapiens_hsa005611.52589365
26Phototransduction_Homo sapiens_hsa047441.47796038
27Chemical carcinogenesis_Homo sapiens_hsa052041.37492497
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36420599
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25719362
30Morphine addiction_Homo sapiens_hsa050321.24646521
31Taste transduction_Homo sapiens_hsa047421.18774780
32Ether lipid metabolism_Homo sapiens_hsa005651.16099327
33ECM-receptor interaction_Homo sapiens_hsa045121.13031065
34Tyrosine metabolism_Homo sapiens_hsa003501.10469296
35Hematopoietic cell lineage_Homo sapiens_hsa046401.09088391
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04688299
37cAMP signaling pathway_Homo sapiens_hsa040241.03095746
38Oxytocin signaling pathway_Homo sapiens_hsa049211.01878581
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01153474
40Retinol metabolism_Homo sapiens_hsa008300.98642831
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.96822530
42Butanoate metabolism_Homo sapiens_hsa006500.96662085
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93059651
44Alcoholism_Homo sapiens_hsa050340.92252661
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92185265
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89048487
47GABAergic synapse_Homo sapiens_hsa047270.88813334
48Ovarian steroidogenesis_Homo sapiens_hsa049130.87214415
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84998689
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84798795
51Circadian rhythm_Homo sapiens_hsa047100.84416918
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84229924
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81969980
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.80798858
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.80375078
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.78118858
57Purine metabolism_Homo sapiens_hsa002300.76830228
58Starch and sucrose metabolism_Homo sapiens_hsa005000.76720099
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75818875
60Dilated cardiomyopathy_Homo sapiens_hsa054140.71914880
61Glutamatergic synapse_Homo sapiens_hsa047240.69583892
62Basal transcription factors_Homo sapiens_hsa030220.69345578
63Lysine degradation_Homo sapiens_hsa003100.68375516
64beta-Alanine metabolism_Homo sapiens_hsa004100.67325509
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.65841870
66ABC transporters_Homo sapiens_hsa020100.64793060
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60359368
68Gap junction_Homo sapiens_hsa045400.60159997
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59666280
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.57347565
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53072023
72RNA polymerase_Homo sapiens_hsa030200.52757452
73Sulfur relay system_Homo sapiens_hsa041220.48733876
74Systemic lupus erythematosus_Homo sapiens_hsa053220.48429976
75Fat digestion and absorption_Homo sapiens_hsa049750.47639310
76Dopaminergic synapse_Homo sapiens_hsa047280.47214420
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46386645
78Pancreatic secretion_Homo sapiens_hsa049720.45385633
79Pyrimidine metabolism_Homo sapiens_hsa002400.43858669
80Asthma_Homo sapiens_hsa053100.43742971
81Phenylalanine metabolism_Homo sapiens_hsa003600.43290675
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.42104388
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.41265723
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37230072
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37203238
86Melanoma_Homo sapiens_hsa052180.36510604
87Viral carcinogenesis_Homo sapiens_hsa052030.35369256
88Insulin resistance_Homo sapiens_hsa049310.33580249
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32236263
90Choline metabolism in cancer_Homo sapiens_hsa052310.31937927
91Cocaine addiction_Homo sapiens_hsa050300.31924931
92Galactose metabolism_Homo sapiens_hsa000520.31322923
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29169854
94One carbon pool by folate_Homo sapiens_hsa006700.28250102
95Rap1 signaling pathway_Homo sapiens_hsa040150.27928609
96Fatty acid degradation_Homo sapiens_hsa000710.26754649
97Chemokine signaling pathway_Homo sapiens_hsa040620.26276604
98Histidine metabolism_Homo sapiens_hsa003400.25359574
99Metabolic pathways_Homo sapiens_hsa011000.24963923
100Legionellosis_Homo sapiens_hsa051340.24551412

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