TATDN2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of histone H3-K27 methylation (GO:0061085)6.74330080
2nuclear pore complex assembly (GO:0051292)6.00452219
3nuclear pore organization (GO:0006999)5.02630661
4pore complex assembly (GO:0046931)4.29121667
5negative regulation of DNA repair (GO:0045738)4.15219929
6pre-miRNA processing (GO:0031054)4.08934632
7positive regulation of gamma-delta T cell activation (GO:0046645)3.90550124
8histone H3-K36 demethylation (GO:0070544)3.87485886
9mitotic sister chromatid cohesion (GO:0007064)3.73302584
10histone H3-K4 methylation (GO:0051568)3.57542758
11dosage compensation (GO:0007549)3.54956496
12T cell migration (GO:0072678)3.54433982
13cytoplasmic mRNA processing body assembly (GO:0033962)3.53778999
14embryonic process involved in female pregnancy (GO:0060136)3.47858251
15face development (GO:0060324)3.47280255
16N-terminal protein amino acid acetylation (GO:0006474)3.44013674
17negative regulation of histone methylation (GO:0031061)3.37845704
18regulation of gamma-delta T cell differentiation (GO:0045586)3.36645100
19monoubiquitinated protein deubiquitination (GO:0035520)3.33212908
20regulation of RNA export from nucleus (GO:0046831)3.29819923
21histone H3-K4 trimethylation (GO:0080182)3.24051997
22regulation of gamma-delta T cell activation (GO:0046643)3.22403487
23phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.21639553
24histone lysine demethylation (GO:0070076)3.18328646
25histone demethylation (GO:0016577)3.14317363
26positive T cell selection (GO:0043368)3.12846067
27positive regulation of granulocyte differentiation (GO:0030854)3.12413708
28cellular response to ethanol (GO:0071361)3.09009401
29negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.06542496
30negative regulation of translation, ncRNA-mediated (GO:0040033)3.06542496
31regulation of translation, ncRNA-mediated (GO:0045974)3.06542496
32DNA duplex unwinding (GO:0032508)3.04491225
33histone H3-K9 demethylation (GO:0033169)3.00862680
34hepatocyte apoptotic process (GO:0097284)2.97628636
35regulation of histone methylation (GO:0031060)2.97430905
36DNA geometric change (GO:0032392)2.95388039
37thymic T cell selection (GO:0045061)2.93817302
38negative thymic T cell selection (GO:0045060)2.92343651
39response to interleukin-15 (GO:0070672)2.91006216
40CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.89760024
41T-helper cell differentiation (GO:0042093)2.89760024
42regulation of establishment of cell polarity (GO:2000114)2.87596892
43negative T cell selection (GO:0043383)2.85610634
44T cell selection (GO:0045058)2.85296918
45positive thymic T cell selection (GO:0045059)2.79191860
46regulation of mRNA catabolic process (GO:0061013)2.79048213
47protein dealkylation (GO:0008214)2.78127300
48protein demethylation (GO:0006482)2.78127300
49regulation of histone H3-K4 methylation (GO:0051569)2.77949092
50regulation of B cell receptor signaling pathway (GO:0050855)2.76453727
51lipid translocation (GO:0034204)2.76423858
52phospholipid translocation (GO:0045332)2.76423858
53histone mRNA catabolic process (GO:0071044)2.75817426
54determination of adult lifespan (GO:0008340)2.75184548
55nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.74002294
56regulation of nucleobase-containing compound transport (GO:0032239)2.73689818
57regulation of histone H3-K9 methylation (GO:0051570)2.73646089
58pinocytosis (GO:0006907)2.73009367
59embryonic hemopoiesis (GO:0035162)2.71354358
60definitive hemopoiesis (GO:0060216)2.71253400
61DNA unwinding involved in DNA replication (GO:0006268)2.69763868
62positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.68406638
63DNA replication initiation (GO:0006270)2.64839372
64response to laminar fluid shear stress (GO:0034616)2.62740490
65TOR signaling (GO:0031929)2.61607777
66mitotic nuclear envelope disassembly (GO:0007077)2.60950976
67megakaryocyte development (GO:0035855)2.59941887
68positive regulation of DNA-templated transcription, initiation (GO:2000144)2.59562405
69positive regulation of mRNA catabolic process (GO:0061014)2.58639438
70glucocorticoid receptor signaling pathway (GO:0042921)2.57065803
71histone lysine methylation (GO:0034968)2.57012328
72peptidyl-lysine trimethylation (GO:0018023)2.56265017
73negative regulation of erythrocyte differentiation (GO:0045647)2.56246298
74response to epidermal growth factor (GO:0070849)2.55447232
75nuclear envelope disassembly (GO:0051081)2.51846270
76membrane disassembly (GO:0030397)2.51846270
77positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.51634045
78regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.51634045
79V(D)J recombination (GO:0033151)2.51629561
80peptidyl-threonine phosphorylation (GO:0018107)2.48967894
81alpha-beta T cell differentiation involved in immune response (GO:0002293)2.48955909
82alpha-beta T cell activation involved in immune response (GO:0002287)2.48955909
83T cell differentiation involved in immune response (GO:0002292)2.48955909
84negative regulation of histone modification (GO:0031057)2.48863981
85cellular response to epidermal growth factor stimulus (GO:0071364)2.48092772
86regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.46816376
87positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.46816376
88RNA stabilization (GO:0043489)2.46387348
89mRNA stabilization (GO:0048255)2.46387348
90B cell receptor signaling pathway (GO:0050853)2.46117845
91plasma lipoprotein particle assembly (GO:0034377)2.45809338
92positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.45766854
93protein export from nucleus (GO:0006611)2.44322005
94regulation of centriole replication (GO:0046599)2.44245158
95peptidyl-threonine modification (GO:0018210)2.42057259
96positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.41126961
97DNA synthesis involved in DNA repair (GO:0000731)2.40213810
98negative regulation of mRNA metabolic process (GO:1903312)2.40071700
993-UTR-mediated mRNA stabilization (GO:0070935)2.39300702
100cellular extravasation (GO:0045123)2.37766752

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.16602812
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.06879549
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.59348496
4MYC_22102868_ChIP-Seq_BL_Human3.34037653
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.23418690
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.05662850
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73985440
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.69821048
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.55356649
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.49990824
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.44604748
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36630635
13RUNX_20019798_ChIP-Seq_JUKART_Human2.31951585
14FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27197611
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21415673
16MYB_26560356_Chip-Seq_TH1_Human2.15991241
17MYB_26560356_Chip-Seq_TH2_Human2.15929576
18GATA1_22025678_ChIP-Seq_K562_Human2.13894787
19ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.04306222
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99098351
21MAF_26560356_Chip-Seq_TH1_Human1.95724358
22TCF7_22412390_ChIP-Seq_EML_Mouse1.92086077
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.88769840
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82267236
25SCL_19346495_ChIP-Seq_HPC-7_Human1.82064792
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73686316
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71240676
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.71020642
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.67824224
30E2F1_21310950_ChIP-Seq_MCF-7_Human1.60758695
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57345083
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.53599388
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52362828
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48457001
35VDR_21846776_ChIP-Seq_THP-1_Human1.47470318
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43850179
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42866711
38UTX_26944678_Chip-Seq_JUKART_Human1.42377159
39PU_27001747_Chip-Seq_BMDM_Mouse1.38015683
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36582412
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.36077504
42GATA3_27048872_Chip-Seq_THYMUS_Human1.31945009
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31195576
44IRF8_27001747_Chip-Seq_BMDM_Mouse1.30791663
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.29604557
46SPI1_23547873_ChIP-Seq_NB4_Human1.28021033
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27482550
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.26771856
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23173314
50VDR_24763502_ChIP-Seq_THP-1_Human1.22270030
51SPI1_23127762_ChIP-Seq_K562_Human1.22066066
52MAF_26560356_Chip-Seq_TH2_Human1.18985686
53CHD1_26751641_Chip-Seq_LNCaP_Human1.18523948
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18264502
55AR_21909140_ChIP-Seq_LNCAP_Human1.17414893
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16431916
57TFEB_21752829_ChIP-Seq_HELA_Human1.15384831
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13400342
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.12494352
60KDM2B_26808549_Chip-Seq_DND41_Human1.12312374
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.11674718
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10277663
63FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10228087
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09604448
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.08063328
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.06432621
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05261910
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05245092
69VDR_24787735_ChIP-Seq_THP-1_Human1.05024488
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05021852
71CIITA_25753668_ChIP-Seq_RAJI_Human1.04797590
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04404543
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03659679
74GATA1_19941826_ChIP-Seq_K562_Human1.03642672
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03102258
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02939473
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02686998
78KDM5A_27292631_Chip-Seq_BREAST_Human1.02538269
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01446250
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01219771
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01118446
82PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00845926
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00363695
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99319557
85GATA2_19941826_ChIP-Seq_K562_Human0.98457553
86GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96190144
87GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96007488
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.93047425
89PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92632914
90NCOR1_26117541_ChIP-Seq_K562_Human0.91637400
91TP63_19390658_ChIP-ChIP_HaCaT_Human0.91227708
92ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90498111
93SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89357879
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88515846
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88408456
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88032034
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.87790816
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86798196
99ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86080012
100GATA1_19941827_ChIP-Seq_MEL_Mouse0.85803541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.01101255
2MP0002396_abnormal_hematopoietic_system3.06040531
3MP0003763_abnormal_thymus_physiology3.03499296
4MP0005076_abnormal_cell_differentiation2.50934616
5MP0008007_abnormal_cellular_replicative2.46073967
6MP0003111_abnormal_nucleus_morphology2.45947419
7MP0010094_abnormal_chromosome_stability2.42143641
8MP0002009_preneoplasia2.31933852
9MP0010352_gastrointestinal_tract_polyps2.31687392
10MP0005451_abnormal_body_composition2.12813719
11MP0002166_altered_tumor_susceptibility2.03262175
12MP0004381_abnormal_hair_follicle1.91784345
13MP0003077_abnormal_cell_cycle1.85012295
14MP0000703_abnormal_thymus_morphology1.82853345
15MP0002398_abnormal_bone_marrow1.78853686
16MP0003172_abnormal_lysosome_physiology1.75114008
17MP0003221_abnormal_cardiomyocyte_apopto1.74212679
18MP0004808_abnormal_hematopoietic_stem1.69993534
19MP0003656_abnormal_erythrocyte_physiolo1.69497779
20MP0008260_abnormal_autophagy1.66575044
21MP0003436_decreased_susceptibility_to1.66102902
22MP0003786_premature_aging1.65708921
23MP0004264_abnormal_extraembryonic_tissu1.63120130
24MP0010307_abnormal_tumor_latency1.56830158
25MP0002006_tumorigenesis1.54063525
26MP0001730_embryonic_growth_arrest1.52954357
27MP0002722_abnormal_immune_system1.51593925
28MP0001800_abnormal_humoral_immune1.48840110
29MP0008058_abnormal_DNA_repair1.46094172
30MP0004957_abnormal_blastocyst_morpholog1.44166508
31MP0003566_abnormal_cell_adhesion1.42655287
32MP0004185_abnormal_adipocyte_glucose1.42123048
33MP0002405_respiratory_system_inflammati1.40375393
34MP0002086_abnormal_extraembryonic_tissu1.39938131
35MP0000689_abnormal_spleen_morphology1.39062735
36MP0003693_abnormal_embryo_hatching1.39048479
37MP0003890_abnormal_embryonic-extraembry1.38260530
38MP0002088_abnormal_embryonic_growth/wei1.38079502
39MP0000350_abnormal_cell_proliferation1.37836416
40MP0003984_embryonic_growth_retardation1.37567802
41MP0003705_abnormal_hypodermis_morpholog1.37471953
42MP0001915_intracranial_hemorrhage1.36828280
43MP0005380_embryogenesis_phenotype1.36778283
44MP0001672_abnormal_embryogenesis/_devel1.36778283
45MP0002420_abnormal_adaptive_immunity1.35066609
46MP0000569_abnormal_digit_pigmentation1.34997474
47MP0005671_abnormal_response_to1.34305845
48MP0004947_skin_inflammation1.32839311
49MP0003303_peritoneal_inflammation1.32630950
50MP0001819_abnormal_immune_cell1.32314611
51MP0000716_abnormal_immune_system1.31667107
52MP0001853_heart_inflammation1.31330173
53MP0001835_abnormal_antigen_presentation1.31228475
54MP0009333_abnormal_splenocyte_physiolog1.27254065
55MP0003300_gastrointestinal_ulcer1.26907669
56MP0005621_abnormal_cell_physiology1.26544663
57MP0002429_abnormal_blood_cell1.26455478
58MP0001873_stomach_inflammation1.25957640
59MP0009278_abnormal_bone_marrow1.25428047
60MP0000685_abnormal_immune_system1.21369398
61MP0002019_abnormal_tumor_incidence1.18856755
62MP0005310_abnormal_salivary_gland1.15856424
63MP0002933_joint_inflammation1.14581851
64MP0004233_abnormal_muscle_weight1.14389402
65MP0002723_abnormal_immune_serum1.14260188
66MP0003828_pulmonary_edema1.14233541
67MP0005409_darkened_coat_color1.14143895
68MP0002452_abnormal_antigen_presenting1.10271945
69MP0001697_abnormal_embryo_size1.08224684
70MP0008961_abnormal_basal_metabolism1.06401968
71MP0003091_abnormal_cell_migration1.06297943
72MP0000858_altered_metastatic_potential1.05441878
73MP0005000_abnormal_immune_tolerance1.05284206
74MP0002419_abnormal_innate_immunity1.03530227
75MP0002080_prenatal_lethality1.02533123
76MP0009672_abnormal_birth_weight1.00606418
77MP0000313_abnormal_cell_death1.00003869
78MP0005397_hematopoietic_system_phenotyp0.99340363
79MP0001545_abnormal_hematopoietic_system0.99340363
80MP0005384_cellular_phenotype0.99295145
81MP0005464_abnormal_platelet_physiology0.96935191
82MP0003453_abnormal_keratinocyte_physiol0.95473084
83MP0002254_reproductive_system_inflammat0.93524912
84MP0005025_abnormal_response_to0.92984006
85MP0002970_abnormal_white_adipose0.87312165
86MP0003943_abnormal_hepatobiliary_system0.85848436
87MP0001790_abnormal_immune_system0.83222445
88MP0005387_immune_system_phenotype0.83222445
89MP0009115_abnormal_fat_cell0.81463541
90MP0002796_impaired_skin_barrier0.81045396
91MP0000609_abnormal_liver_physiology0.80910124
92MP0004197_abnormal_fetal_growth/weight/0.77626283
93MP0010630_abnormal_cardiac_muscle0.76160846
94MP0010155_abnormal_intestine_physiology0.76143180
95MP0008995_early_reproductive_senescence0.75991628
96MP0003115_abnormal_respiratory_system0.74726953
97MP0000598_abnormal_liver_morphology0.74132931
98MP0001851_eye_inflammation0.73100672
99MP0005075_abnormal_melanosome_morpholog0.72493054
100MP0005164_abnormal_response_to0.72432103

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)3.98244305
2Abnormality of the fingertips (HP:0001211)3.62446921
3Abnormality of T cell number (HP:0011839)3.38687213
4Gastrointestinal infarctions (HP:0005244)3.00885308
5Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.93897445
6Birth length less than 3rd percentile (HP:0003561)2.90751823
7Pustule (HP:0200039)2.88885150
8Recurrent viral infections (HP:0004429)2.88478095
9Acute myeloid leukemia (HP:0004808)2.87504805
10Asymmetry of the thorax (HP:0001555)2.83595334
11Subacute progressive viral hepatitis (HP:0006572)2.75974161
12Ankyloglossia (HP:0010296)2.73402803
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73092624
14Septate vagina (HP:0001153)2.68512727
15Long eyelashes (HP:0000527)2.58993344
16IgA deficiency (HP:0002720)2.58598347
17Abnormality of oral frenula (HP:0000190)2.56767586
18Anal stenosis (HP:0002025)2.49505390
19Prominent nose (HP:0000448)2.47796563
20Chromsome breakage (HP:0040012)2.43870975
21Acute lymphatic leukemia (HP:0006721)2.39753127
22Sandal gap (HP:0001852)2.38694828
23Deep venous thrombosis (HP:0002625)2.33046032
24Abnormality of T cells (HP:0002843)2.27885726
25Colitis (HP:0002583)2.27738793
26Abnormal hair whorl (HP:0010721)2.26863205
27Nephroblastoma (Wilms tumor) (HP:0002667)2.26394129
28Basal cell carcinoma (HP:0002671)2.19591781
29Viral hepatitis (HP:0006562)2.18748185
30Dyschromatopsia (HP:0007641)2.17800286
31Flat acetabular roof (HP:0003180)2.12397510
32Dislocated radial head (HP:0003083)2.11947797
33Narrow palate (HP:0000189)2.10122829
34Embryonal renal neoplasm (HP:0011794)2.07409382
35Chin dimple (HP:0010751)2.06569631
36Diastasis recti (HP:0001540)2.05774944
37Myocardial infarction (HP:0001658)2.04523314
38Abnormality of chromosome stability (HP:0003220)2.02451411
39Eczematoid dermatitis (HP:0000976)2.02023045
40Rhabdomyosarcoma (HP:0002859)2.00532287
41Cafe-au-lait spot (HP:0000957)2.00097177
42Acanthocytosis (HP:0001927)1.97170341
43Amaurosis fugax (HP:0100576)1.96080369
44Recurrent bacterial skin infections (HP:0005406)1.95751497
45Gastrointestinal carcinoma (HP:0002672)1.94847918
46Malignant gastrointestinal tract tumors (HP:0006749)1.94847918
47Heterotopia (HP:0002282)1.90515997
48Abnormality of the common coagulation pathway (HP:0010990)1.90067590
49Deep philtrum (HP:0002002)1.89028048
50Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.88769409
51Abnormality of the radial head (HP:0003995)1.87254291
52Abnormal foot bone ossification (HP:0010675)1.86444364
53Recurrent fungal infections (HP:0002841)1.85698561
54Abnormality of the columella (HP:0009929)1.84234007
55Submucous cleft hard palate (HP:0000176)1.84216994
56Granulocytopenia (HP:0001913)1.83500918
57Fair hair (HP:0002286)1.82222335
58Autoimmune hemolytic anemia (HP:0001890)1.81952216
59Recurrent abscess formation (HP:0002722)1.81598148
60Poikilocytosis (HP:0004447)1.79721069
61Menorrhagia (HP:0000132)1.79616229
62Myelodysplasia (HP:0002863)1.78018988
63Intestinal fistula (HP:0100819)1.77842382
64Papillary thyroid carcinoma (HP:0002895)1.76934091
65Delayed closure of the anterior fontanelle (HP:0001476)1.76044413
66Central scotoma (HP:0000603)1.75765528
67Cellular immunodeficiency (HP:0005374)1.75723893
68Skull defect (HP:0001362)1.74942068
69Panhypogammaglobulinemia (HP:0003139)1.73679902
70Dysmetric saccades (HP:0000641)1.72447258
71Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69853255
72Progressive external ophthalmoplegia (HP:0000590)1.68787055
73Thick nail (HP:0001805)1.68485650
74Inflammation of the large intestine (HP:0002037)1.66660056
75Short chin (HP:0000331)1.65625174
76IgM deficiency (HP:0002850)1.65594091
77Coarse hair (HP:0002208)1.65563539
78Prolonged bleeding time (HP:0003010)1.64937995
79Hepatitis (HP:0012115)1.64501183
80Gastrointestinal inflammation (HP:0004386)1.63900393
81Aplasia/Hypoplasia of the thymus (HP:0010515)1.63241306
82Slow saccadic eye movements (HP:0000514)1.62913952
83Abnormality of the preputium (HP:0100587)1.61286651
84Uterine leiomyosarcoma (HP:0002891)1.61233299
85Leiomyosarcoma (HP:0100243)1.61233299
86Macroorchidism (HP:0000053)1.60832771
87Breast hypoplasia (HP:0003187)1.60811172
88Syringomyelia (HP:0003396)1.60306128
89Spinal cord lesions (HP:0100561)1.60306128
90Abnormal platelet volume (HP:0011876)1.60271061
91Eosinophilia (HP:0001880)1.60267301
92Combined immunodeficiency (HP:0005387)1.59884070
93Obsessive-compulsive behavior (HP:0000722)1.59704485
94Abnormal delayed hypersensitivity skin test (HP:0002963)1.59691559
95Urethral obstruction (HP:0000796)1.59041208
96Medulloblastoma (HP:0002885)1.58770967
97Hemorrhage of the eye (HP:0011885)1.58358602
98Clubbing of toes (HP:0100760)1.58081011
99Cone-rod dystrophy (HP:0000548)1.57967045
100Abnormality of the thymus (HP:0000777)1.57676124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.44445329
2PRPF4B2.52362455
3MAP4K12.45935520
4MAP3K102.29131255
5BRD42.24788402
6EEF2K2.20522973
7PKN21.99978328
8MAP3K141.97219715
9FGFR41.97106104
10TRIB31.94041984
11CAMK1D1.86742253
12FGFR31.85076087
13MELK1.79112129
14NLK1.75457625
15MAP2K31.64480639
16CDK41.61079603
17ICK1.52725037
18MAP3K131.51685264
19BRSK21.43099528
20CAMK1G1.42698851
21SMG11.41379861
22BTK1.38567950
23ITK1.34827609
24ZAP701.31368691
25IRAK31.29293827
26TEC1.28900570
27TAOK31.26684624
28MAP3K21.24896502
29BLK1.21020448
30MKNK21.19248209
31MTOR1.17845405
32CDK61.17791207
33PASK1.17410642
34WNK11.16899465
35RIPK41.16823003
36TSSK61.16003644
37TRPM71.15211353
38IRAK11.14447571
39SGK31.04076823
40RET1.03362690
41SGK21.02945559
42TTN1.01462754
43RPS6KB20.98008250
44HCK0.97936732
45AKT30.97077788
46CDC70.95802222
47KSR20.94457541
48IRAK40.93379747
49PRKAA20.93091675
50MARK30.90433826
51EIF2AK30.89035199
52GRK60.87796449
53JAK10.87766877
54STK100.84868179
55JAK30.84060584
56TGFBR20.83847434
57TXK0.82344008
58STK40.82268015
59PIM10.81860473
60MARK20.81461240
61CHEK10.79763341
62ATR0.78498694
63FLT30.78265677
64YES10.77686731
65MKNK10.77339955
66TYK20.76379792
67MAPK110.75007485
68CSK0.73853590
69INSRR0.72726667
70SYK0.72524759
71TTK0.71224944
72ACVR1B0.69281400
73FGR0.68834677
74MAP3K70.68635647
75PDK10.68612988
76IKBKB0.67806053
77NEK60.67002184
78EIF2AK10.65623391
79LCK0.65437538
80FGFR10.65419699
81PAK20.63923053
82RAF10.62388687
83IRAK20.61855753
84PDGFRB0.60963294
85SIK30.60722881
86NEK90.59684130
87CLK10.59427624
88LATS10.56834758
89SRPK10.54849860
90CHEK20.54286547
91CHUK0.53322174
92IKBKE0.53176526
93PBK0.53167774
94ATM0.52900054
95CDK70.51408639
96MAP3K10.51262949
97RPS6KB10.50381729
98PLK40.49976058
99CDC42BPA0.48738454
100ALK0.47430679

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-small cell lung cancer_Homo sapiens_hsa052232.30116903
2T cell receptor signaling pathway_Homo sapiens_hsa046602.18112039
3Acute myeloid leukemia_Homo sapiens_hsa052212.15494598
4Chronic myeloid leukemia_Homo sapiens_hsa052202.13187024
5Pancreatic cancer_Homo sapiens_hsa052121.97402231
6Non-homologous end-joining_Homo sapiens_hsa034501.94884144
7B cell receptor signaling pathway_Homo sapiens_hsa046621.93183363
8Lysine degradation_Homo sapiens_hsa003101.80212837
9Prostate cancer_Homo sapiens_hsa052151.70955978
10Cell cycle_Homo sapiens_hsa041101.59757727
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.57857120
12DNA replication_Homo sapiens_hsa030301.56408266
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.56289278
14Colorectal cancer_Homo sapiens_hsa052101.55617496
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54713457
16Hepatitis B_Homo sapiens_hsa051611.49931269
17Thyroid cancer_Homo sapiens_hsa052161.48248550
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47155861
19Endometrial cancer_Homo sapiens_hsa052131.45297161
20Measles_Homo sapiens_hsa051621.44352784
21MicroRNAs in cancer_Homo sapiens_hsa052061.42604815
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36951624
23Renal cell carcinoma_Homo sapiens_hsa052111.35648054
24mTOR signaling pathway_Homo sapiens_hsa041501.33188841
25Primary immunodeficiency_Homo sapiens_hsa053401.32490502
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31505340
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30204213
28Osteoclast differentiation_Homo sapiens_hsa043801.28955030
29Viral carcinogenesis_Homo sapiens_hsa052031.26750453
30Leishmaniasis_Homo sapiens_hsa051401.24400153
31FoxO signaling pathway_Homo sapiens_hsa040681.24187060
32Inositol phosphate metabolism_Homo sapiens_hsa005621.22860813
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22304009
34Small cell lung cancer_Homo sapiens_hsa052221.19829821
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17253981
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15490508
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.14898446
38TNF signaling pathway_Homo sapiens_hsa046681.13741564
39mRNA surveillance pathway_Homo sapiens_hsa030151.11310694
40Choline metabolism in cancer_Homo sapiens_hsa052311.10751624
41Legionellosis_Homo sapiens_hsa051341.07659510
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04776907
43ErbB signaling pathway_Homo sapiens_hsa040121.04625001
44Apoptosis_Homo sapiens_hsa042101.04547215
45VEGF signaling pathway_Homo sapiens_hsa043701.03323089
46Central carbon metabolism in cancer_Homo sapiens_hsa052301.03184186
47Other glycan degradation_Homo sapiens_hsa005111.02541514
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.01903345
49Adherens junction_Homo sapiens_hsa045201.00308927
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00105020
51Toxoplasmosis_Homo sapiens_hsa051451.00048507
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.98342437
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97438736
54Prolactin signaling pathway_Homo sapiens_hsa049170.97430203
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97381741
56RNA transport_Homo sapiens_hsa030130.97190939
57Mismatch repair_Homo sapiens_hsa034300.97132880
58Herpes simplex infection_Homo sapiens_hsa051680.96977314
59Insulin resistance_Homo sapiens_hsa049310.95046417
60HIF-1 signaling pathway_Homo sapiens_hsa040660.94777703
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93620444
62Glioma_Homo sapiens_hsa052140.93405694
63Influenza A_Homo sapiens_hsa051640.92381981
64Platelet activation_Homo sapiens_hsa046110.91255706
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.91170874
66Fanconi anemia pathway_Homo sapiens_hsa034600.90982457
67Hematopoietic cell lineage_Homo sapiens_hsa046400.87601285
68Proteoglycans in cancer_Homo sapiens_hsa052050.87457981
69Hepatitis C_Homo sapiens_hsa051600.86535856
70One carbon pool by folate_Homo sapiens_hsa006700.84310122
71Spliceosome_Homo sapiens_hsa030400.84097830
72HTLV-I infection_Homo sapiens_hsa051660.83801297
73Epstein-Barr virus infection_Homo sapiens_hsa051690.80448651
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80009011
75Bladder cancer_Homo sapiens_hsa052190.79397699
76Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79369576
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76014948
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.74818782
79p53 signaling pathway_Homo sapiens_hsa041150.74606658
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.74074758
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73618621
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72366686
83Type II diabetes mellitus_Homo sapiens_hsa049300.68570945
84Insulin signaling pathway_Homo sapiens_hsa049100.68157424
85Circadian rhythm_Homo sapiens_hsa047100.66764179
86Fatty acid biosynthesis_Homo sapiens_hsa000610.66241499
87Homologous recombination_Homo sapiens_hsa034400.64851515
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64055424
89Notch signaling pathway_Homo sapiens_hsa043300.62017801
90Antigen processing and presentation_Homo sapiens_hsa046120.61611049
91Dorso-ventral axis formation_Homo sapiens_hsa043200.60726090
92Base excision repair_Homo sapiens_hsa034100.59810149
93RNA degradation_Homo sapiens_hsa030180.58165841
94Tuberculosis_Homo sapiens_hsa051520.57837413
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.56388048
96Focal adhesion_Homo sapiens_hsa045100.54579246
97Chemokine signaling pathway_Homo sapiens_hsa040620.54111985
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53532127
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52961914
100MAPK signaling pathway_Homo sapiens_hsa040100.52045206

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