ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	actin-myosin filament sliding (GO:0033275)	8.87278734
2	muscle filament sliding (GO:0030049)	8.87278734
3	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	8.76541388
4	skeletal muscle contraction (GO:0003009)	7.60704255
5	actin-mediated cell contraction (GO:0070252)	7.57041642
6	sarcomere organization (GO:0045214)	6.88839096
7	response to inactivity (GO:0014854)	6.86497024
8	striated muscle atrophy (GO:0014891)	6.65645175
9	sarcoplasmic reticulum calcium ion transport (GO:0070296)	6.52094342
10	skeletal muscle adaptation (GO:0043501)	6.42158081
11	striated muscle contraction (GO:0006941)	5.68878667
12	muscle atrophy (GO:0014889)	5.62886815
13	actin filament-based movement (GO:0030048)	5.61375802
14	regulation of skeletal muscle contraction (GO:0014819)	5.57147931
15	myofibril assembly (GO:0030239)	5.20915810
16	myoblast fusion (GO:0007520)	5.03779339
17	cardiac myofibril assembly (GO:0055003)	5.01085050
18	mesonephros development (GO:0001823)	4.95217683
19	regulation of relaxation of muscle (GO:1901077)	4.84935460
20	actomyosin structure organization (GO:0031032)	4.69068458
21	cardiac muscle contraction (GO:0060048)	4.61073184
22	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	4.57853025
23	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	4.54529322
24	syncytium formation by plasma membrane fusion (GO:0000768)	4.42337360
25	striated muscle adaptation (GO:0014888)	4.31374959
26	muscle contraction (GO:0006936)	4.26399678
27	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	4.24344031
28	plasma membrane repair (GO:0001778)	4.22614212
29	response to muscle activity (GO:0014850)	4.17510311
30	negative regulation of potassium ion transmembrane transport (GO:1901380)	4.17057315
31	post-embryonic morphogenesis (GO:0009886)	4.02086010
32	regulation of centriole replication (GO:0046599)	3.95717860
33	skeletal muscle tissue development (GO:0007519)	3.95300821
34	muscle system process (GO:0003012)	3.84499005
35	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.82680435
36	negative regulation of cell size (GO:0045792)	3.81890605
37	cardiac muscle hypertrophy (GO:0003300)	3.81386594
38	muscle cell cellular homeostasis (GO:0046716)	3.75121453
39	regulation of cell communication by electrical coupling (GO:0010649)	3.69149249
40	muscle cell fate commitment (GO:0042693)	3.66522155
41	striated muscle hypertrophy (GO:0014897)	3.66519582
42	cardiac muscle cell development (GO:0055013)	3.64676244
43	syncytium formation (GO:0006949)	3.64543319
44	otic vesicle formation (GO:0030916)	3.61224901
45	regulation of branching involved in prostate gland morphogenesis (GO:0060687)	3.58998329
46	muscle organ development (GO:0007517)	3.56251902
47	cardiac muscle tissue morphogenesis (GO:0055008)	3.55992842
48	vagina development (GO:0060068)	3.54443400
49	muscle structure development (GO:0061061)	3.51901310
50	carnitine shuttle (GO:0006853)	3.51094679
51	NADH metabolic process (GO:0006734)	3.47338529
52	muscle tissue morphogenesis (GO:0060415)	3.45310616
53	skeletal muscle fiber development (GO:0048741)	3.43683599
54	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	3.40040416
55	muscle adaptation (GO:0043500)	3.39770539
56	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.38006649
57	cardiac cell development (GO:0055006)	3.36132067
58	myotube cell development (GO:0014904)	3.35687494
59	regulation of actin filament-based movement (GO:1903115)	3.34828535
60	regulation of membrane repolarization (GO:0060306)	3.31851622
61	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.29684352
62	regulation of histone H3-K27 methylation (GO:0061085)	3.29507379
63	muscle hypertrophy (GO:0014896)	3.28864750
64	positive regulation of keratinocyte differentiation (GO:0045618)	3.28730652
65	ventricular cardiac muscle cell action potential (GO:0086005)	3.28566268
66	intestinal epithelial cell development (GO:0060576)	3.28415886
67	regulation of establishment of cell polarity (GO:2000114)	3.28016881
68	regulation of striated muscle contraction (GO:0006942)	3.23075319
69	regulation of sarcomere organization (GO:0060297)	3.22533538
70	positive regulation of myotube differentiation (GO:0010831)	3.18778433
71	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.17748792
72	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.17619221
73	fatty acid transmembrane transport (GO:1902001)	3.13463534
74	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.10434053
75	negative regulation of protein localization to cell surface (GO:2000009)	3.08192698
76	positive regulation of microtubule polymerization (GO:0031116)	3.06790861
77	negative regulation of Ras GTPase activity (GO:0034261)	3.01936625
78	negative regulation of organelle assembly (GO:1902116)	3.01272806
79	oligosaccharide catabolic process (GO:0009313)	3.01153815
80	striated muscle tissue development (GO:0014706)	3.00756922
81	tricarboxylic acid cycle (GO:0006099)	2.97444035
82	regulation of female receptivity (GO:0045924)	2.96619849
83	positive regulation of myoblast differentiation (GO:0045663)	2.95932871
84	creatine metabolic process (GO:0006600)	2.87255755
85	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.85927412
86	positive regulation of glycogen biosynthetic process (GO:0045725)	2.81736506
87	striated muscle cell development (GO:0055002)	2.80130181
88	carnitine transmembrane transport (GO:1902603)	2.79608086
89	regulation of fatty acid oxidation (GO:0046320)	2.75548498
90	muscle fiber development (GO:0048747)	2.75412638
91	muscle tissue development (GO:0060537)	2.75198667
92	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.74205229
93	regulation of cell proliferation involved in kidney development (GO:1901722)	2.72833925
94	amino-acid betaine transport (GO:0015838)	2.71991676
95	carnitine transport (GO:0015879)	2.71991676
96	cell-substrate adherens junction assembly (GO:0007045)	2.71850804
97	focal adhesion assembly (GO:0048041)	2.71850804
98	ear development (GO:0043583)	2.70039337
99	regulation of muscle system process (GO:0090257)	2.67571541
100	female genitalia development (GO:0030540)	2.66762304

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_20079471_ChIP-ChIP_T-47D_Human	7.47334144
2	ESR1_21235772_ChIP-Seq_MCF-7_Human	6.40117622
3	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	6.11947069
4	ESR2_21235772_ChIP-Seq_MCF-7_Human	5.87274852
5	ZNF217_24962896_ChIP-Seq_MCF-7_Human	3.97808800
6	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	3.26387566
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.21742007
8	ESR1_15608294_ChIP-ChIP_MCF-7_Human	3.18147009
9	AHR_22903824_ChIP-Seq_MCF-7_Human	3.16934944
10	RUNX1_27514584_Chip-Seq_MCF-7_Human	3.02920173
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.97528282
12	ZNF263_19887448_ChIP-Seq_K562_Human	2.91589232
13	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.89231767
14	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	2.77958740
15	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.73264776
16	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.72150932
17	TDRD3_21172665_ChIP-Seq_MCF-7_Human	2.61346218
18	ARNT_22903824_ChIP-Seq_MCF-7_Human	2.57056082
19	GATA1_22025678_ChIP-Seq_K562_Human	2.55891683
20	FOXM1_26456572_ChIP-Seq_MCF-7_Human	2.41976628
21	GATA3_24758297_ChIP-Seq_MCF-7_Human	2.29056485
22	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.20177166
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.17906481
24	TBX20_22328084_ChIP-Seq_HEART_Mouse	2.13161304
25	TBX20_22080862_ChIP-Seq_HEART_Mouse	2.13161304
26	RACK7_27058665_Chip-Seq_MCF-7_Human	1.92433000
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.82490906
28	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.71666538
29	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.59812710
30	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.55335249
31	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.46813750
32	AR_21572438_ChIP-Seq_LNCaP_Human	1.45764084
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.32440803
34	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.27531519
35	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.26972368
36	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.26848668
37	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.26425398
38	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.25436647
39	GATA4_21415370_ChIP-Seq_HL-1_Mouse	1.19651362
40	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.17691178
41	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.16232644
42	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14414340
43	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.09148888
44	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.09143262
45	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.06537813
46	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.04698966
47	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.01689208
48	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.99886621
49	IGF1R_20145208_ChIP-Seq_DFB_Human	0.99635225
50	SCL_19346495_ChIP-Seq_HPC-7_Human	0.98767326
51	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.97277774
52	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.95002035
53	CJUN_26792858_Chip-Seq_BT549_Human	0.90103782
54	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.86299549
55	HOXB7_26014856_ChIP-Seq_BT474_Human	0.84014508
56	SMC4_20622854_ChIP-Seq_HELA_Human	0.83555096
57	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.82226341
58	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.81512748
59	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.81512748
60	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.81018597
61	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.79663725
62	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.79415396
63	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.78758679
64	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.75503688
65	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.74722167
66	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.74568989
67	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.74096447
68	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.72681684
69	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	0.72332370
70	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.72089448
71	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.71599326
72	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.71448928
73	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.71232859
74	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.70327558
75	CTCF_27219007_Chip-Seq_Bcells_Human	0.70074826
76	CTCF_21964334_Chip-Seq_Bcells_Human	0.67478334
77	TP63_22573176_ChIP-Seq_HFKS_Human	0.67246051
78	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.66428711
79	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.65970244
80	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.65934366
81	DROSHA_22980978_ChIP-Seq_HELA_Human	0.65595117
82	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.65471869
83	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.65026210
84	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.64239703
85	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.63720383
86	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.62532465
87	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.61296173
88	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.60672557
89	CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.60087337
90	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.60014754
91	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.59850550
92	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.59850550
93	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.59850550
94	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.59680353
95	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.59530060
96	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	0.58663419
97	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.58109342
98	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.56789901
99	GBX2_23144817_ChIP-Seq_PC3_Human	0.56272390
100	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.55332363

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000749_muscle_degeneration	5.91916367
2	MP0000751_myopathy	4.59398945
3	MP0004145_abnormal_muscle_electrophysio	3.88621828
4	MP0000750_abnormal_muscle_regeneration	3.68460856
5	MP0003646_muscle_fatigue	3.67590043
6	MP0004510_myositis	3.40628641
7	MP0002269_muscular_atrophy	3.08076152
8	MP0004087_abnormal_muscle_fiber	3.02552208
9	MP0000747_muscle_weakness	2.97219391
10	MP0002106_abnormal_muscle_physiology	2.92172829
11	MP0004233_abnormal_muscle_weight	2.79911305
12	MP0002108_abnormal_muscle_morphology	2.78166984
13	MP0000759_abnormal_skeletal_muscle	2.74390094
14	MP0005369_muscle_phenotype	2.73844884
15	MP0004036_abnormal_muscle_relaxation	2.68850059
16	MP0004084_abnormal_cardiac_muscle	2.51230907
17	MP0002822_catalepsy	2.49060230
18	MP0005620_abnormal_muscle_contractility	2.47682135
19	MP0005330_cardiomyopathy	2.39983184
20	MP0010030_abnormal_orbit_morphology	2.32422437
21	MP0002837_dystrophic_cardiac_calcinosis	2.23120093
22	MP0002332_abnormal_exercise_endurance	2.20853143
23	MP0001661_extended_life_span	2.12957430
24	MP0005451_abnormal_body_composition	2.11812054
25	MP0002127_abnormal_cardiovascular_syste	1.93175116
26	MP0003705_abnormal_hypodermis_morpholog	1.88691997
27	MP0004484_altered_response_of	1.85873008
28	MP0002972_abnormal_cardiac_muscle	1.79867902
29	MP0000733_abnormal_muscle_development	1.79737109
30	MP0010630_abnormal_cardiac_muscle	1.78110122
31	MP0009780_abnormal_chondrocyte_physiolo	1.71304476
32	MP0004130_abnormal_muscle_cell	1.69368998
33	MP0003137_abnormal_impulse_conducting	1.61268589
34	MP0002254_reproductive_system_inflammat	1.61057012
35	MP0004215_abnormal_myocardial_fiber	1.56873888
36	MP0000569_abnormal_digit_pigmentation	1.51179391
37	MP0004270_analgesia	1.42943539
38	MP0000383_abnormal_hair_follicle	1.41788251
39	MP0000462_abnormal_digestive_system	1.38171358
40	MP0004264_abnormal_extraembryonic_tissu	1.36210074
41	MP0005083_abnormal_biliary_tract	1.30534767
42	MP0005503_abnormal_tendon_morphology	1.30435404
43	MP0005385_cardiovascular_system_phenoty	1.29866338
44	MP0001544_abnormal_cardiovascular_syste	1.29866338
45	MP0005058_abnormal_lysosome_morphology	1.28899009
46	MP0003950_abnormal_plasma_membrane	1.27174158
47	MP0002249_abnormal_larynx_morphology	1.23650567
48	MP0003191_abnormal_cellular_cholesterol	1.22379197
49	MP0003941_abnormal_skin_development	1.17899514
50	MP0002909_abnormal_adrenal_gland	1.15436284
51	MP0009384_cardiac_valve_regurgitation	1.15146782
52	MP0005248_abnormal_Harderian_gland	1.03398033
53	MP0005423_abnormal_somatic_nervous	0.98008875
54	MP0008438_abnormal_cutaneous_collagen	0.97284520
55	MP0004085_abnormal_heartbeat	0.89518997
56	MP0002160_abnormal_reproductive_system	0.89011358
57	MP0006138_congestive_heart_failure	0.87111212
58	MP0005076_abnormal_cell_differentiation	0.87106423
59	MP0003942_abnormal_urinary_system	0.86658599
60	MP0005275_abnormal_skin_tensile	0.84990135
61	MP0005266_abnormal_metabolism	0.84339815
62	MP0000013_abnormal_adipose_tissue	0.83060865
63	MP0005670_abnormal_white_adipose	0.82332146
64	MP0000579_abnormal_nail_morphology	0.81969189
65	MP0000266_abnormal_heart_morphology	0.80861382
66	MP0010678_abnormal_skin_adnexa	0.78536200
67	MP0004381_abnormal_hair_follicle	0.77931506
68	MP0000470_abnormal_stomach_morphology	0.77181844
69	MP0003567_abnormal_fetal_cardiomyocyte	0.75052652
70	MP0003221_abnormal_cardiomyocyte_apopto	0.73468538
71	MP0008775_abnormal_heart_ventricle	0.70659264
72	MP0000566_synostosis	0.69581671
73	MP0005165_increased_susceptibility_to	0.67514017
74	MP0000467_abnormal_esophagus_morphology	0.66575479
75	MP0002971_abnormal_brown_adipose	0.65748561
76	MP0002114_abnormal_axial_skeleton	0.62963000
77	MP0000762_abnormal_tongue_morphology	0.62959610
78	MP0006036_abnormal_mitochondrial_physio	0.60452466
79	MP0000534_abnormal_ureter_morphology	0.60214167
80	MP0001542_abnormal_bone_strength	0.59387826
81	MP0001340_abnormal_eyelid_morphology	0.58898549
82	MP0001958_emphysema	0.58871388
83	MP0009672_abnormal_birth_weight	0.58513759
84	MP0003638_abnormal_response/metabolism_	0.57859067
85	MP0002089_abnormal_postnatal_growth/wei	0.52346941
86	MP0000427_abnormal_hair_cycle	0.51027058
87	MP0000371_diluted_coat_color	0.50951724
88	MP0003123_paternal_imprinting	0.50176216
89	MP0003948_abnormal_gas_homeostasis	0.50124233
90	MP0009046_muscle_twitch	0.49823733
91	MP0002796_impaired_skin_barrier	0.48730323
92	MP0002128_abnormal_blood_circulation	0.48003335
93	MP0003828_pulmonary_edema	0.47591975
94	MP0009840_abnormal_foam_cell	0.47537735
95	MP0005595_abnormal_vascular_smooth	0.47410285
96	MP0000003_abnormal_adipose_tissue	0.47106567
97	MP0001529_abnormal_vocalization	0.46357267
98	MP0000538_abnormal_urinary_bladder	0.46239698
99	MP0000767_abnormal_smooth_muscle	0.45943889
100	MP0005646_abnormal_pituitary_gland	0.45882083

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	7.74587450
2	Muscle fiber inclusion bodies (HP:0100299)	7.59497848
3	Nemaline bodies (HP:0003798)	7.59306796
4	Type 1 muscle fiber predominance (HP:0003803)	6.02126969
5	Hyporeflexia of lower limbs (HP:0002600)	5.97982724
6	Popliteal pterygium (HP:0009756)	5.60871497
7	Exercise-induced myalgia (HP:0003738)	5.48810970
8	Calf muscle hypertrophy (HP:0008981)	5.12457453
9	Muscle hypertrophy of the lower extremities (HP:0008968)	4.94481634
10	Exercise-induced muscle cramps (HP:0003710)	4.84053541
11	Abnormality of the calf musculature (HP:0001430)	4.77605122
12	Distal arthrogryposis (HP:0005684)	4.64067011
13	Fetal akinesia sequence (HP:0001989)	4.26173000
14	Sudden death (HP:0001699)	4.24762711
15	Ulnar deviation of the wrist (HP:0003049)	4.19855098
16	EMG: myopathic abnormalities (HP:0003458)	4.15130583
17	Muscle fiber splitting (HP:0003555)	4.00049469
18	Malignant hyperthermia (HP:0002047)	3.99132443
19	Type 2 muscle fiber atrophy (HP:0003554)	3.96428797
20	Bundle branch block (HP:0011710)	3.94717894
21	Asymmetric septal hypertrophy (HP:0001670)	3.93753144
22	Aplasia of the musculature (HP:0100854)	3.87489702
23	Round ear (HP:0100830)	3.81502670
24	Areflexia of lower limbs (HP:0002522)	3.75943748
25	Muscle fiber atrophy (HP:0100295)	3.70259520
26	Abnormality of placental membranes (HP:0011409)	3.67630068
27	Amniotic constriction ring (HP:0009775)	3.67630068
28	Neck muscle weakness (HP:0000467)	3.67040596
29	Abnormality of the neuromuscular junction (HP:0003398)	3.63092765
30	Fatigable weakness (HP:0003473)	3.63092765
31	Myopathic facies (HP:0002058)	3.61802992
32	Distal lower limb muscle weakness (HP:0009053)	3.59480618
33	Gowers sign (HP:0003391)	3.53854326
34	EMG: neuropathic changes (HP:0003445)	3.30458420
35	Ventricular tachycardia (HP:0004756)	3.19920069
36	Subaortic stenosis (HP:0001682)	3.15418238
37	Abnormality of the left ventricular outflow tract (HP:0011103)	3.15418238
38	Calcaneovalgus deformity (HP:0001848)	3.05803832
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.05452658
40	Abnormality of alanine metabolism (HP:0010916)	3.05452658
41	Hyperalaninemia (HP:0003348)	3.05452658
42	Absent phalangeal crease (HP:0006109)	3.00283108
43	Bulbar palsy (HP:0001283)	2.87116316
44	Difficulty running (HP:0009046)	2.86397169
45	Rimmed vacuoles (HP:0003805)	2.85881443
46	Weak cry (HP:0001612)	2.78294115
47	Myoglobinuria (HP:0002913)	2.73443161
48	Deformed tarsal bones (HP:0008119)	2.72024959
49	Rhabdomyolysis (HP:0003201)	2.71720042
50	Lipoatrophy (HP:0100578)	2.70973996
51	Mildly elevated creatine phosphokinase (HP:0008180)	2.61394233
52	Pterygium (HP:0001059)	2.60592297
53	Dilated cardiomyopathy (HP:0001644)	2.59334475
54	J-shaped sella turcica (HP:0002680)	2.58443409
55	Hypoplastic ischia (HP:0003175)	2.57505048
56	Easy fatigability (HP:0003388)	2.54891591
57	Generalized muscle weakness (HP:0003324)	2.51128290
58	Abnormal finger flexion creases (HP:0006143)	2.49296848
59	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.46689955
60	Ventricular arrhythmia (HP:0004308)	2.37453239
61	Atrial fibrillation (HP:0005110)	2.33502487
62	Ventricular fibrillation (HP:0001663)	2.32848256
63	Increased connective tissue (HP:0009025)	2.31992603
64	Pheochromocytoma (HP:0002666)	2.27325949
65	Abnormality of the ischium (HP:0003174)	2.26183497
66	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.25804886
67	Akinesia (HP:0002304)	2.21297414
68	Increased variability in muscle fiber diameter (HP:0003557)	2.19474707
69	Microglossia (HP:0000171)	2.17717122
70	Abnormality of skeletal muscle fiber size (HP:0012084)	2.17205741
71	Thin ribs (HP:0000883)	2.14521164
72	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.14202086
73	Diaphragmatic weakness (HP:0009113)	2.11082800
74	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.10382968
75	Primary atrial arrhythmia (HP:0001692)	2.09095652
76	Syncope (HP:0001279)	2.04725528
77	Supraventricular tachycardia (HP:0004755)	2.04436456
78	Muscle stiffness (HP:0003552)	2.04378086
79	Cystic hygroma (HP:0000476)	2.03172883
80	Frequent falls (HP:0002359)	2.01920361
81	Progressive muscle weakness (HP:0003323)	2.00800163
82	Hypercortisolism (HP:0001578)	2.00498878
83	Supraventricular arrhythmia (HP:0005115)	1.99668747
84	Septate vagina (HP:0001153)	1.99534538
85	Steppage gait (HP:0003376)	1.98277435
86	Heart block (HP:0012722)	1.92896282
87	Breech presentation (HP:0001623)	1.91037891
88	Increased neuronal autofluorescent lipopigment (HP:0002074)	1.89011575
89	Meningioma (HP:0002858)	1.88874047
90	Myotonia (HP:0002486)	1.88505179
91	Duplicated collecting system (HP:0000081)	1.87675543
92	Palpitations (HP:0001962)	1.82662589
93	Abnormal atrioventricular conduction (HP:0005150)	1.82581402
94	Abnormality of the renal collecting system (HP:0004742)	1.82425998
95	Neuroendocrine neoplasm (HP:0100634)	1.82151804
96	Abnormality of the sella turcica (HP:0002679)	1.81950981
97	Chromsome breakage (HP:0040012)	1.81455489
98	Muscular dystrophy (HP:0003560)	1.80687753
99	Scapular winging (HP:0003691)	1.79449416
100	Hypoplastic heart (HP:0001961)	1.78156670

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OBSCN	7.87475781
2	PIK3CA	3.64013818
3	MUSK	3.59516966
4	TRIB3	3.55718988
5	SCYL2	3.35235619
6	SIK1	3.13383708
7	TTN	2.95367611
8	RPS6KB2	2.57116082
9	PHKG1	2.53725333
10	PHKG2	2.53725333
11	PKN2	2.44414223
12	GRK1	1.84070610
13	MAPKAPK3	1.67134603
14	MAP3K9	1.60439064
15	TRPM7	1.55642004
16	EEF2K	1.54181809
17	LIMK1	1.38869956
18	CHUK	1.36448101
19	KSR2	1.30784975
20	MAP2K2	1.30287986
21	MAP3K12	1.26124997
22	MAPK12	1.25433380
23	NEK6	1.25269982
24	ADRBK2	1.24895120
25	LATS1	1.19846929
26	DMPK	1.17555972
27	AKT2	1.15490179
28	MAP3K7	1.13583500
29	CAMK2G	1.11102779
30	PIK3CG	1.10491233
31	CAMK2D	1.09918301
32	STK16	1.09776475
33	RPS6KB1	1.08946549
34	MAP2K1	1.06641699
35	MAP3K2	1.05156778
36	RPS6KA6	1.03708861
37	FGFR3	1.01807834
38	TESK2	1.00488003
39	MYLK	0.99796891
40	ERBB3	0.98117172
41	RPS6KL1	0.92383647
42	RPS6KC1	0.92383647
43	FGFR4	0.89214325
44	CAMK2B	0.88243950
45	MAP3K1	0.82131546
46	RPS6KA2	0.80238381
47	DDR2	0.77818167
48	MAP4K2	0.75811748
49	RET	0.75478392
50	CSF1R	0.74487094
51	EPHA2	0.72386784
52	DYRK1B	0.70016216
53	PDK2	0.69926049
54	MTOR	0.69283375
55	ILK	0.67012049
56	IKBKB	0.65324158
57	ZAK	0.64440524
58	PRKD1	0.62009776
59	RPS6KA1	0.61778187
60	PDPK1	0.61673599
61	NME2	0.60779757
62	TBK1	0.58529549
63	MAPK7	0.56820067
64	PDGFRA	0.56641401
65	ROCK1	0.55304080
66	MAPK4	0.55226602
67	MAP3K3	0.54562777
68	CCNB1	0.53754677
69	DAPK3	0.53153044
70	TAOK2	0.51637699
71	PRKAA2	0.50464683
72	PRKG1	0.48127349
73	PRKAA1	0.46326828
74	ADRBK1	0.45482830
75	MAP2K4	0.44643573
76	IKBKE	0.43191142
77	MAP2K3	0.42449217
78	MAPKAPK2	0.40452336
79	IRAK4	0.39904279
80	ROCK2	0.39304214
81	MAP3K11	0.37966583
82	TLK1	0.37486042
83	GRK6	0.36868170
84	PDK1	0.36008918
85	PRKACB	0.35021463
86	PBK	0.34843415
87	NEK9	0.33266740
88	KSR1	0.32994872
89	PRKCE	0.31650844
90	CAMK2A	0.31031042
91	GRK7	0.30998564
92	ARAF	0.29905269
93	MAPK11	0.28357043
94	CDK7	0.28256052
95	RAF1	0.28220111
96	FGFR2	0.28168694
97	NME1	0.26934200
98	FGFR1	0.25975957
99	MAPK10	0.25782518
100	CAMK4	0.25258633

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	4.78233293
2	Dilated cardiomyopathy_Homo sapiens_hsa05414	4.64844695
3	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	3.57067654
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.41694839
5	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.04878099
6	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.50166558
7	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.28562763
8	Pentose phosphate pathway_Homo sapiens_hsa00030	2.00316277
9	Insulin signaling pathway_Homo sapiens_hsa04910	1.97848886
10	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.89248233
11	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.83196601
12	Other glycan degradation_Homo sapiens_hsa00511	1.82792096
13	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.79754782
14	mTOR signaling pathway_Homo sapiens_hsa04150	1.78102484
15	Insulin resistance_Homo sapiens_hsa04931	1.71609098
16	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.66011320
17	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.58754707
18	AMPK signaling pathway_Homo sapiens_hsa04152	1.56632809
19	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.52013523
20	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.50467604
21	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.47971229
22	Carbon metabolism_Homo sapiens_hsa01200	1.46245155
23	Tight junction_Homo sapiens_hsa04530	1.43162201
24	Calcium signaling pathway_Homo sapiens_hsa04020	1.34847116
25	Endometrial cancer_Homo sapiens_hsa05213	1.33524601
26	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.31548743
27	Circadian rhythm_Homo sapiens_hsa04710	1.30119357
28	Thyroid cancer_Homo sapiens_hsa05216	1.27927287
29	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.21976285
30	Pyruvate metabolism_Homo sapiens_hsa00620	1.20268271
31	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.19983855
32	Ribosome_Homo sapiens_hsa03010	1.17295855
33	Bladder cancer_Homo sapiens_hsa05219	1.16118826
34	Glucagon signaling pathway_Homo sapiens_hsa04922	1.15622444
35	Propanoate metabolism_Homo sapiens_hsa00640	1.06440826
36	Melanoma_Homo sapiens_hsa05218	1.04719341
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.03932869
38	ABC transporters_Homo sapiens_hsa02010	1.03761621
39	Acute myeloid leukemia_Homo sapiens_hsa05221	0.96403147
40	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.95012366
41	Non-small cell lung cancer_Homo sapiens_hsa05223	0.91319463
42	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.90980721
43	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.87667974
44	Alcoholism_Homo sapiens_hsa05034	0.84920854
45	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.83688921
46	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.80136548
47	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.79544047
48	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.79171112
49	Focal adhesion_Homo sapiens_hsa04510	0.78038286
50	Estrogen signaling pathway_Homo sapiens_hsa04915	0.77246129
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.76903083
52	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.76212664
53	GnRH signaling pathway_Homo sapiens_hsa04912	0.74685313
54	ErbB signaling pathway_Homo sapiens_hsa04012	0.74305576
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.72234957
56	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.67961761
57	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.67387980
58	Sphingolipid metabolism_Homo sapiens_hsa00600	0.66374523
59	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.66264795
60	Choline metabolism in cancer_Homo sapiens_hsa05231	0.65205640
61	Renal cell carcinoma_Homo sapiens_hsa05211	0.64239881
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.64003416
63	Glioma_Homo sapiens_hsa05214	0.63018392
64	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.62816772
65	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.61368364
66	Lysine degradation_Homo sapiens_hsa00310	0.60956847
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60951856
68	FoxO signaling pathway_Homo sapiens_hsa04068	0.60632664
69	Proteoglycans in cancer_Homo sapiens_hsa05205	0.57907760
70	Viral myocarditis_Homo sapiens_hsa05416	0.55411098
71	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.53340228
72	Protein digestion and absorption_Homo sapiens_hsa04974	0.50721079
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50617862
74	Lysosome_Homo sapiens_hsa04142	0.50564121
75	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.50406336
76	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.50137781
77	Amoebiasis_Homo sapiens_hsa05146	0.49174657
78	Galactose metabolism_Homo sapiens_hsa00052	0.47440620
79	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.46690094
80	VEGF signaling pathway_Homo sapiens_hsa04370	0.45261767
81	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.45123492
82	Hepatitis C_Homo sapiens_hsa05160	0.42702962
83	Small cell lung cancer_Homo sapiens_hsa05222	0.42357139
84	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.42300498
85	Platelet activation_Homo sapiens_hsa04611	0.41811993
86	Alzheimers disease_Homo sapiens_hsa05010	0.40321059
87	ECM-receptor interaction_Homo sapiens_hsa04512	0.39419210
88	Prolactin signaling pathway_Homo sapiens_hsa04917	0.38226308
89	Tryptophan metabolism_Homo sapiens_hsa00380	0.37809420
90	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.37549650
91	RNA degradation_Homo sapiens_hsa03018	0.37497702
92	Sulfur relay system_Homo sapiens_hsa04122	0.37232372
93	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.34980055
94	MAPK signaling pathway_Homo sapiens_hsa04010	0.33061345
95	Arginine and proline metabolism_Homo sapiens_hsa00330	0.31107797
96	Gastric acid secretion_Homo sapiens_hsa04971	0.29805834
97	Oxidative phosphorylation_Homo sapiens_hsa00190	0.27311180
98	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.27248370
99	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.27148162
100	Phenylalanine metabolism_Homo sapiens_hsa00360	0.26791680

TATDN2P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »