TAX1BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)5.44671312
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.16003053
3proteasome assembly (GO:0043248)4.71309571
4epithelial cilium movement (GO:0003351)4.69245375
5cilium movement (GO:0003341)4.60637993
6regulation of meiosis I (GO:0060631)4.57230445
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.54907157
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.54907157
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.27593237
10centriole replication (GO:0007099)4.25665062
11hepatocyte apoptotic process (GO:0097284)4.23192067
12cilium or flagellum-dependent cell motility (GO:0001539)4.13414942
13keratinocyte development (GO:0003334)4.06293438
14antigen processing and presentation of endogenous antigen (GO:0019883)3.96994831
15membrane budding (GO:0006900)3.91160914
16pyrimidine-containing compound transmembrane transport (GO:0072531)3.88344131
17intraciliary transport (GO:0042073)3.85225851
18protein localization to cilium (GO:0061512)3.84334161
19polyketide metabolic process (GO:0030638)3.78689581
20doxorubicin metabolic process (GO:0044598)3.78689581
21daunorubicin metabolic process (GO:0044597)3.78689581
22UDP-N-acetylglucosamine metabolic process (GO:0006047)3.72872152
23retinal cone cell development (GO:0046549)3.68787084
24positive regulation of protein autophosphorylation (GO:0031954)3.65948342
25piRNA metabolic process (GO:0034587)3.52676775
26protein targeting to Golgi (GO:0000042)3.52217673
27axoneme assembly (GO:0035082)3.50641818
28meiotic cell cycle (GO:0051321)3.45196973
29regulation of cilium movement (GO:0003352)3.43691000
30negative regulation of phagocytosis (GO:0050765)3.42667281
31negative regulation of cell cycle G2/M phase transition (GO:1902750)3.36950411
32response to redox state (GO:0051775)3.35042200
33establishment of protein localization to Golgi (GO:0072600)3.34120589
34ribonucleoprotein complex disassembly (GO:0032988)3.32020981
35negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.31337469
36retrograde transport, vesicle recycling within Golgi (GO:0000301)3.27265432
37cilium morphogenesis (GO:0060271)3.23131822
38nuclear pore complex assembly (GO:0051292)3.19859448
39organelle disassembly (GO:1903008)3.18515008
40thrombin receptor signaling pathway (GO:0070493)3.17519240
41hormone catabolic process (GO:0042447)3.17394060
42interleukin-6-mediated signaling pathway (GO:0070102)3.17335365
43aminoglycoside antibiotic metabolic process (GO:0030647)3.11791688
44interferon-gamma production (GO:0032609)3.09194329
45natural killer cell mediated cytotoxicity (GO:0042267)3.07755310
46natural killer cell mediated immunity (GO:0002228)3.07755310
47Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05486386
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.03236879
49intra-Golgi vesicle-mediated transport (GO:0006891)3.00833415
50multicellular organism reproduction (GO:0032504)2.98218516
51centriole assembly (GO:0098534)2.94956740
52cilium organization (GO:0044782)2.94824971
53cilium assembly (GO:0042384)2.92486676
54metaphase plate congression (GO:0051310)2.88935248
55regulation of cellular amino acid metabolic process (GO:0006521)2.87847304
56pore complex assembly (GO:0046931)2.87593643
57regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.87043917
58regulation of protein glycosylation (GO:0060049)2.85953520
59protein localization to kinetochore (GO:0034501)2.85189435
60establishment of chromosome localization (GO:0051303)2.83306384
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.82945179
62peptide catabolic process (GO:0043171)2.80420747
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.79833848
64positive regulation of gamma-delta T cell activation (GO:0046645)2.78092215
65genitalia morphogenesis (GO:0035112)2.76564444
66synapsis (GO:0007129)2.75318189
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.75136812
68actin nucleation (GO:0045010)2.74454698
69COPII vesicle coating (GO:0048208)2.74389148
70ER overload response (GO:0006983)2.74216854
71relaxation of smooth muscle (GO:0044557)2.71424639
72neutrophil activation involved in immune response (GO:0002283)2.70751758
73regulation of acrosome reaction (GO:0060046)2.68722661
74valine metabolic process (GO:0006573)2.67542878
75production of molecular mediator involved in inflammatory response (GO:0002532)2.67012542
76positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.65060421
77organelle membrane fusion (GO:0090174)2.64448345
78acrosome assembly (GO:0001675)2.64253014
79Golgi to plasma membrane protein transport (GO:0043001)2.63790985
80regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.62935845
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62697866
82vascular smooth muscle contraction (GO:0014829)2.62168777
83cullin deneddylation (GO:0010388)2.61392162
84hypotonic response (GO:0006971)2.61212271
85left/right axis specification (GO:0070986)2.59895421
86positive regulation of B cell differentiation (GO:0045579)2.59257317
87protein neddylation (GO:0045116)2.55766382
88branched-chain amino acid catabolic process (GO:0009083)2.55475362
89immunoglobulin mediated immune response (GO:0016064)2.55264648
90protein K11-linked ubiquitination (GO:0070979)2.54945877
91necroptotic process (GO:0070266)2.54549062
92angiotensin maturation (GO:0002003)2.54455281
93early endosome to late endosome transport (GO:0045022)2.52581078
94female gamete generation (GO:0007292)2.51322687
95definitive hemopoiesis (GO:0060216)2.50923418
96megakaryocyte development (GO:0035855)2.49001579
97magnesium ion transport (GO:0015693)2.48345111
98negative regulation of bone resorption (GO:0045779)2.47762169
99nucleotide transmembrane transport (GO:1901679)2.47450946
100protein localization to Golgi apparatus (GO:0034067)2.47298040
101nuclear pore organization (GO:0006999)2.45540037
102somite rostral/caudal axis specification (GO:0032525)2.45111271
103mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.45021992
104JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.42989095
105regulation of cell communication by electrical coupling (GO:0010649)2.42472213
106COPI coating of Golgi vesicle (GO:0048205)2.42166709
107Golgi transport vesicle coating (GO:0048200)2.42166709
108positive regulation of histone H3-K4 methylation (GO:0051571)2.41866656
109heart process (GO:0003015)2.41695050
110heart contraction (GO:0060047)2.41695050
111negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.40780788
112antigen processing and presentation via MHC class Ib (GO:0002475)2.40741325
113positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.38479483
114DNA methylation involved in gamete generation (GO:0043046)2.38062879
115regulation of necroptotic process (GO:0060544)2.37304225
116regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.37232726
117mitotic sister chromatid cohesion (GO:0007064)2.37012385
118regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.35253656
119cellular component assembly involved in morphogenesis (GO:0010927)2.35206153
120ER to Golgi vesicle-mediated transport (GO:0006888)2.34830037
121regulation of female gonad development (GO:2000194)2.34716632
122terpenoid biosynthetic process (GO:0016114)2.34482675
123regulation of gamma-delta T cell differentiation (GO:0045586)2.34400863
124growth hormone receptor signaling pathway (GO:0060396)2.34336858
125retinal metabolic process (GO:0042574)2.34253566
126mitotic metaphase plate congression (GO:0007080)2.34210303
127positive regulation of protein import into nucleus, translocation (GO:0033160)2.34164082
128positive regulation of protein deacetylation (GO:0090312)2.33534075
129response to type I interferon (GO:0034340)2.33502499
130motile cilium assembly (GO:0044458)2.32988756
131protein localization to chromosome, centromeric region (GO:0071459)2.32921365
132regulation of RIG-I signaling pathway (GO:0039535)2.32619881
133L-serine transport (GO:0015825)2.32565569
134DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.32458451
135resolution of meiotic recombination intermediates (GO:0000712)2.32400702
136negative regulation of JUN kinase activity (GO:0043508)2.32089097
137positive regulation of histone deacetylation (GO:0031065)2.32058936
138interferon-gamma-mediated signaling pathway (GO:0060333)2.31968125
139negative regulation of B cell proliferation (GO:0030889)2.31881445
140regulation of response to interferon-gamma (GO:0060330)2.31358342
141regulation of DNA methylation (GO:0044030)2.30888621
142leukocyte mediated cytotoxicity (GO:0001909)2.30659219
143male meiosis (GO:0007140)2.30270291
144regulation of B cell differentiation (GO:0045577)2.29927929
145regulation of protein autophosphorylation (GO:0031952)2.29814933
146prenylation (GO:0097354)2.29182401
147protein prenylation (GO:0018342)2.29182401
148glutathione derivative metabolic process (GO:1901685)2.29129329
149glutathione derivative biosynthetic process (GO:1901687)2.29129329
150regulation of integrin-mediated signaling pathway (GO:2001044)2.28747467
151positive regulation of actin filament depolymerization (GO:0030836)2.28608331
152positive regulation of ligase activity (GO:0051351)2.28110255
153B cell mediated immunity (GO:0019724)2.27683141
154male meiosis I (GO:0007141)2.27330036
155protein deneddylation (GO:0000338)2.27215021
156mitotic chromosome condensation (GO:0007076)2.24609362
157intestinal epithelial cell development (GO:0060576)2.24540247
158sequestering of metal ion (GO:0051238)2.24216850
159neutrophil activation (GO:0042119)2.23637605
160monoubiquitinated protein deubiquitination (GO:0035520)2.20408147
161regulation of interleukin-12 biosynthetic process (GO:0045075)2.20149924
162negative regulation of lipid storage (GO:0010888)2.19803550
163cellular response to type I interferon (GO:0071357)2.18784734
164type I interferon signaling pathway (GO:0060337)2.18784734
165response to hydroperoxide (GO:0033194)2.18753699
166positive regulation of interferon-alpha production (GO:0032727)2.18583666
167intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.18356966
168regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.16746302
169regulation of gamma-delta T cell activation (GO:0046643)2.15954291
170negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.14784213
171thyroid hormone generation (GO:0006590)2.14409666
172reactive oxygen species biosynthetic process (GO:1903409)2.14116676
173establishment of endothelial barrier (GO:0061028)2.14090140
174regulation of interferon-alpha production (GO:0032647)2.12572598
175positive regulation of macrophage differentiation (GO:0045651)2.12266222
176embryonic process involved in female pregnancy (GO:0060136)2.12033464
177positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.11635389
178positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.11635389
179positive regulation of mitotic sister chromatid separation (GO:1901970)2.11635389
180regulation of DNA endoreduplication (GO:0032875)2.11549664
181cytidine catabolic process (GO:0006216)2.10183725
182cytidine deamination (GO:0009972)2.10183725
183cytidine metabolic process (GO:0046087)2.10183725
184positive regulation of respiratory burst (GO:0060267)2.10059046
185toxin transport (GO:1901998)2.09636055
186diterpenoid biosynthetic process (GO:0016102)2.09353675
187regulation of interferon-beta biosynthetic process (GO:0045357)2.09165938
188glycoside metabolic process (GO:0016137)2.08532961
189regulation of apoptotic cell clearance (GO:2000425)2.08531598
190response to muramyl dipeptide (GO:0032495)2.06401188
191cellular response to growth hormone stimulus (GO:0071378)2.06087612
192drug transmembrane transport (GO:0006855)2.04639087
193positive regulation of defense response to virus by host (GO:0002230)2.03698366
194positive regulation of p38MAPK cascade (GO:1900745)2.03644783
195NLS-bearing protein import into nucleus (GO:0006607)2.03300062
196intestinal absorption (GO:0050892)2.02583551
197positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.01906523

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.97225260
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.11666892
3E2F7_22180533_ChIP-Seq_HELA_Human3.45069366
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.04920901
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.96190918
6GATA1_22025678_ChIP-Seq_K562_Human2.84729856
7MYB_21317192_ChIP-Seq_ERMYB_Mouse2.83601362
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.70644381
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69275465
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.65918549
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65884182
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54651765
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.36406753
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.34974693
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32731412
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.30853302
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29896169
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.29444439
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28211940
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27688023
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26466680
22* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22988490
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21962608
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20537421
25* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.12960818
26IRF8_27001747_Chip-Seq_BMDM_Mouse2.12548454
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.09437262
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04101978
29TAF15_26573619_Chip-Seq_HEK293_Human2.02052004
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01513421
31FUS_26573619_Chip-Seq_HEK293_Human2.00862662
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99627086
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98115119
34* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.97352287
35P300_19829295_ChIP-Seq_ESCs_Human1.96112478
36* GABP_17652178_ChIP-ChIP_JURKAT_Human1.93482633
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.91218303
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90824580
39VDR_22108803_ChIP-Seq_LS180_Human1.90043192
40SCL_19346495_ChIP-Seq_HPC-7_Human1.89505397
41* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88576599
42GBX2_23144817_ChIP-Seq_PC3_Human1.87345816
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82657339
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.81494509
45ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75977138
46AR_21909140_ChIP-Seq_LNCAP_Human1.75470116
47MYB_26560356_Chip-Seq_TH2_Human1.75350201
48SMAD4_21799915_ChIP-Seq_A2780_Human1.68838293
49* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68827321
50* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.68209064
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67105191
52* PIAS1_25552417_ChIP-Seq_VCAP_Human1.66437472
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63573399
54ER_23166858_ChIP-Seq_MCF-7_Human1.63541437
55EWS_26573619_Chip-Seq_HEK293_Human1.63532881
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.63215097
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61151598
58* SPI1_23547873_ChIP-Seq_NB4_Human1.61118579
59* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60140832
60* MYB_26560356_Chip-Seq_TH1_Human1.58419981
61RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57298674
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54703782
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54479897
64CBP_20019798_ChIP-Seq_JUKART_Human1.54479897
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54348761
66FOXO3_23340844_ChIP-Seq_DLD1_Human1.53291687
67* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52489668
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.52095129
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.51299231
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.51126485
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51090574
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.50997621
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.50869336
74RUNX_20019798_ChIP-Seq_JUKART_Human1.49132987
75CDX2_22108803_ChIP-Seq_LS180_Human1.46811687
76GATA4_25053715_ChIP-Seq_YYC3_Human1.46808272
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.45149334
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.43945018
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.43129817
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41523418
81* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39197856
82CLOCK_20551151_ChIP-Seq_293T_Human1.38590373
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.38367557
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37750000
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.37244439
86BCAT_22108803_ChIP-Seq_LS180_Human1.36285018
87* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36265862
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36220937
89* RUNX1_22412390_ChIP-Seq_EML_Mouse1.35927879
90* AR_25329375_ChIP-Seq_VCAP_Human1.35561951
91EST1_17652178_ChIP-ChIP_JURKAT_Human1.35203932
92* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34922747
93* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34922747
94E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33487497
95EGR1_23403033_ChIP-Seq_LIVER_Mouse1.32536499
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32360038
97HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31717849
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31178016
99STAT3_23295773_ChIP-Seq_U87_Human1.31128102
100TCF4_22108803_ChIP-Seq_LS180_Human1.30775815
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30502680
102GATA3_27048872_Chip-Seq_THYMUS_Human1.30171984
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.29822763
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28914220
105* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.28905048
106ZNF274_21170338_ChIP-Seq_K562_Hela1.27751125
107P53_22387025_ChIP-Seq_ESCs_Mouse1.27209737
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.26965970
109* GATA6_25053715_ChIP-Seq_YYC3_Human1.25769278
110EP300_21415370_ChIP-Seq_HL-1_Mouse1.25398796
111CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24210160
112SOX2_19829295_ChIP-Seq_ESCs_Human1.23936717
113NANOG_19829295_ChIP-Seq_ESCs_Human1.23936717
114IGF1R_20145208_ChIP-Seq_DFB_Human1.23282079
115PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22917659
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22354961
117CRX_20693478_ChIP-Seq_RETINA_Mouse1.22241322
118PU_27001747_Chip-Seq_BMDM_Mouse1.22181383
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21490280
120CJUN_26792858_Chip-Seq_BT549_Human1.21348955
121GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20811791
122ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20209707
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.20012172
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19220957
125LXR_22158963_ChIP-Seq_LIVER_Mouse1.19194479
126* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18744319
127ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18527349
128GATA3_26560356_Chip-Seq_TH2_Human1.18435116
129* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17395505
130* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17395505
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16797987
132* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16207283
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15939922
134P300_18555785_Chip-Seq_ESCs_Mouse1.15710163
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15690641
136SOX2_20726797_ChIP-Seq_SW620_Human1.15651551
137TCF4_23295773_ChIP-Seq_U87_Human1.15446127
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15375185
139SOX2_18555785_Chip-Seq_ESCs_Mouse1.15207205
140STAT3_18555785_Chip-Seq_ESCs_Mouse1.14334991
141HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13976700
142NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12865928
143OCT4_18555785_Chip-Seq_ESCs_Mouse1.12141568
144TAL1_26923725_Chip-Seq_HPCs_Mouse1.10492432
145RXR_22158963_ChIP-Seq_LIVER_Mouse1.10185044
146FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09823824
147KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08717484
148SALL4_22934838_ChIP-ChIP_CD34+_Human1.07950509
149SMAD4_21741376_ChIP-Seq_EPCs_Human1.07921254
150TP53_18474530_ChIP-ChIP_U2OS_Human1.07668243
151CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06545113
152* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06415447
153RUNX2_22187159_ChIP-Seq_PCA_Human1.06234681
154* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04915907
155FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04772664
156WT1_19549856_ChIP-ChIP_CCG9911_Human1.04006477
157CDX2_20551321_ChIP-Seq_CACO-2_Human1.03952263
158TP63_23658742_ChIP-Seq_EP156T_Human1.03665598
159* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03369850
160* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03092818
161ESR1_21235772_ChIP-Seq_MCF-7_Human1.02540781
162TP63_19390658_ChIP-ChIP_HaCaT_Human1.02005773
163* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01314942
164TCF7_22412390_ChIP-Seq_EML_Mouse0.98260813
165HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98255197
166TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97640926
167CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96179581
168MAF_26560356_Chip-Seq_TH1_Human0.94435656
169SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93961396
170PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93393131
171NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93116457
172LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91995986
173KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91751636
174KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91751636
175KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91751636
176GATA2_19941826_ChIP-Seq_K562_Human0.90640926
177FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90051629
178PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89246964
179SPI1_23127762_ChIP-Seq_K562_Human0.88590647
180* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88568823
181* ELK1_19687146_ChIP-ChIP_HELA_Human0.88220849
182TFEB_21752829_ChIP-Seq_HELA_Human0.86739364
183TCF4_18268006_ChIP-ChIP_LS174T_Human0.85833403
184CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85721722
185GATA3_24758297_ChIP-Seq_MCF-7_Human0.85032342
186CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82305029
187VDR_24763502_ChIP-Seq_THP-1_Human0.80649540
188NCOR1_26117541_ChIP-Seq_K562_Human0.80359426
189GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79183506
190NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.78891173
191UTX_26944678_Chip-Seq_JUKART_Human0.78680728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.81018275
2MP0003718_maternal_effect3.75291081
3MP0009780_abnormal_chondrocyte_physiolo3.52466019
4MP0008877_abnormal_DNA_methylation3.44976180
5MP0001984_abnormal_olfaction3.42391732
6MP0003950_abnormal_plasma_membrane3.36220577
7MP0004264_abnormal_extraembryonic_tissu3.11583570
8MP0003011_delayed_dark_adaptation2.82342250
9MP0000569_abnormal_digit_pigmentation2.69511862
10MP0010352_gastrointestinal_tract_polyps2.57245112
11MP0003890_abnormal_embryonic-extraembry2.56862192
12MP0002166_altered_tumor_susceptibility2.43679838
13MP0003300_gastrointestinal_ulcer2.30955279
14MP0001835_abnormal_antigen_presentation2.26964182
15MP0002254_reproductive_system_inflammat2.21441693
16MP0000372_irregular_coat_pigmentation2.17231716
17MP0002396_abnormal_hematopoietic_system2.16885546
18MP0000427_abnormal_hair_cycle2.15392967
19MP0002006_tumorigenesis2.10558491
20MP0008789_abnormal_olfactory_epithelium2.05134165
21MP0002009_preneoplasia2.04905418
22MP0005395_other_phenotype1.99526796
23MP0004215_abnormal_myocardial_fiber1.98038937
24MP0002877_abnormal_melanocyte_morpholog1.94702951
25MP0009785_altered_susceptibility_to1.89626710
26MP0000647_abnormal_sebaceous_gland1.85447428
27MP0000516_abnormal_urinary_system1.84106144
28MP0005367_renal/urinary_system_phenotyp1.84106144
29MP0003183_abnormal_peptide_metabolism1.81526386
30MP0010155_abnormal_intestine_physiology1.80126411
31MP0005360_urolithiasis1.77996502
32MP0005248_abnormal_Harderian_gland1.75485213
33MP0003436_decreased_susceptibility_to1.73387986
34MP0010386_abnormal_urinary_bladder1.64127355
35MP0003806_abnormal_nucleotide_metabolis1.62495020
36MP0003724_increased_susceptibility_to1.62472201
37MP0003941_abnormal_skin_development1.55724886
38MP0006054_spinal_hemorrhage1.54844494
39MP0010307_abnormal_tumor_latency1.51491957
40MP0005410_abnormal_fertilization1.50766084
41MP0002234_abnormal_pharynx_morphology1.49374511
42MP0000490_abnormal_crypts_of1.47082703
43MP0002909_abnormal_adrenal_gland1.46238768
44MP0005025_abnormal_response_to1.45584879
45MP0003191_abnormal_cellular_cholesterol1.42325769
46MP0008004_abnormal_stomach_pH1.42050365
47MP0002102_abnormal_ear_morphology1.41370596
48MP0002090_abnormal_vision1.40935148
49MP0005000_abnormal_immune_tolerance1.38399735
50* MP0002419_abnormal_innate_immunity1.38367506
51MP0005499_abnormal_olfactory_system1.37511595
52MP0005394_taste/olfaction_phenotype1.37511595
53MP0002638_abnormal_pupillary_reflex1.36494398
54MP0005671_abnormal_response_to1.34921826
55MP0001800_abnormal_humoral_immune1.34620028
56MP0005464_abnormal_platelet_physiology1.34409152
57MP0006082_CNS_inflammation1.33784668
58MP0001845_abnormal_inflammatory_respons1.32135938
59* MP0002452_abnormal_antigen_presenting1.31583991
60MP0003868_abnormal_feces_composition1.31523407
61MP0006072_abnormal_retinal_apoptosis1.31010332
62* MP0004947_skin_inflammation1.30581821
63MP0001790_abnormal_immune_system1.29784720
64MP0005387_immune_system_phenotype1.29784720
65MP0000465_gastrointestinal_hemorrhage1.29167768
66MP0004084_abnormal_cardiac_muscle1.28404350
67MP0003866_abnormal_defecation1.27199736
68MP0003195_calcinosis1.26897104
69MP0003763_abnormal_thymus_physiology1.26221174
70* MP0002420_abnormal_adaptive_immunity1.26166208
71* MP0001819_abnormal_immune_cell1.26081544
72MP0004484_altered_response_of1.26049876
73MP0002876_abnormal_thyroid_physiology1.25765543
74MP0001873_stomach_inflammation1.25717882
75MP0004808_abnormal_hematopoietic_stem1.24267122
76MP0008875_abnormal_xenobiotic_pharmacok1.23353975
77MP0004782_abnormal_surfactant_physiolog1.23071221
78MP0005075_abnormal_melanosome_morpholog1.21510361
79MP0003787_abnormal_imprinting1.21320937
80* MP0002148_abnormal_hypersensitivity_rea1.21014282
81MP0002139_abnormal_hepatobiliary_system1.20925916
82MP0008058_abnormal_DNA_repair1.20848174
83MP0002405_respiratory_system_inflammati1.20704148
84* MP0002723_abnormal_immune_serum1.19217173
85MP0000627_abnormal_mammary_gland1.17950288
86MP0009764_decreased_sensitivity_to1.17934847
87MP0005397_hematopoietic_system_phenotyp1.17858504
88MP0001545_abnormal_hematopoietic_system1.17858504
89MP0003186_abnormal_redox_activity1.17652128
90MP0005174_abnormal_tail_pigmentation1.17577039
91MP0003656_abnormal_erythrocyte_physiolo1.17496651
92MP0003566_abnormal_cell_adhesion1.15258057
93MP0010678_abnormal_skin_adnexa1.14464424
94MP0005310_abnormal_salivary_gland1.14454373
95MP0005551_abnormal_eye_electrophysiolog1.14434020
96MP0001666_abnormal_nutrient_absorption1.12752850
97MP0003252_abnormal_bile_duct1.12493998
98MP0001929_abnormal_gametogenesis1.12315549
99MP0000685_abnormal_immune_system1.11978554
100MP0000858_altered_metastatic_potential1.11928072
101MP0004019_abnormal_vitamin_homeostasis1.09681785
102MP0005253_abnormal_eye_physiology1.09616069
103MP0005171_absent_coat_pigmentation1.09568822
104MP0003303_peritoneal_inflammation1.08767361
105MP0003880_abnormal_central_pattern1.08555024
106MP0003705_abnormal_hypodermis_morpholog1.08290797
107MP0002837_dystrophic_cardiac_calcinosis1.08233186
108MP0002138_abnormal_hepatobiliary_system1.07876990
109MP0004147_increased_porphyrin_level1.07181190
110MP0004043_abnormal_pH_regulation1.06784671
111MP0001881_abnormal_mammary_gland1.06728241
112MP0002160_abnormal_reproductive_system1.06195092
113MP0005365_abnormal_bile_salt1.05902505
114MP0002398_abnormal_bone_marrow1.04369480
115MP0005187_abnormal_penis_morphology1.01897243
116MP0003448_altered_tumor_morphology1.01816887
117MP0001216_abnormal_epidermal_layer1.01593179
118MP0002095_abnormal_skin_pigmentation1.01588737
119MP0002295_abnormal_pulmonary_circulatio1.01407144
120MP0000716_abnormal_immune_system1.01139229
121MP0005023_abnormal_wound_healing1.00998421
122MP0001764_abnormal_homeostasis1.00922485
123MP0005085_abnormal_gallbladder_physiolo1.00787153
124MP0009643_abnormal_urine_homeostasis1.00395298
125MP0000609_abnormal_liver_physiology0.99514426
126MP0005319_abnormal_enzyme/_coenzyme0.99339006
127MP0003453_abnormal_keratinocyte_physiol0.99214993
128MP0008469_abnormal_protein_level0.98374602
129MP0001533_abnormal_skeleton_physiology0.98170360
130MP0002722_abnormal_immune_system0.97459410
131MP0010329_abnormal_lipoprotein_level0.96343091
132MP0000689_abnormal_spleen_morphology0.93812099
133MP0005646_abnormal_pituitary_gland0.93439099
134MP0005636_abnormal_mineral_homeostasis0.93006592
135MP0000343_altered_response_to0.92943437
136MP0002136_abnormal_kidney_physiology0.91680789
137MP0000015_abnormal_ear_pigmentation0.91333936
138MP0002132_abnormal_respiratory_system0.90832568
139MP0002233_abnormal_nose_morphology0.89933683
140MP0002429_abnormal_blood_cell0.88090137
141MP0005408_hypopigmentation0.86958465
142MP0005389_reproductive_system_phenotype0.86387234
143MP0002796_impaired_skin_barrier0.86029399
144MP0004085_abnormal_heartbeat0.85511601
145MP0002019_abnormal_tumor_incidence0.84940326
146MP0002060_abnormal_skin_morphology0.83862434
147MP0000377_abnormal_hair_follicle0.83835892
148MP0005058_abnormal_lysosome_morphology0.83035855
149MP0002272_abnormal_nervous_system0.81476599
150MP0002210_abnormal_sex_determination0.80860828
151MP0000653_abnormal_sex_gland0.79054654
152MP0001756_abnormal_urination0.78978019
153MP0005076_abnormal_cell_differentiation0.78876385
154MP0002098_abnormal_vibrissa_morphology0.78630835
155MP0001191_abnormal_skin_condition0.77534542
156MP0001324_abnormal_eye_pigmentation0.77434519
157MP0004957_abnormal_blastocyst_morpholog0.76389027
158MP0009697_abnormal_copulation0.76108760
159MP0002277_abnormal_respiratory_mucosa0.74812795
160MP0000383_abnormal_hair_follicle0.74522876
161MP0006036_abnormal_mitochondrial_physio0.73267194
162MP0000639_abnormal_adrenal_gland0.73066338
163MP0009046_muscle_twitch0.72683261
164MP0002168_other_aberrant_phenotype0.72547675
165MP0008057_abnormal_DNA_replication0.72495709
166MP0002972_abnormal_cardiac_muscle0.71400659
167MP0001765_abnormal_ion_homeostasis0.71011440
168MP0004142_abnormal_muscle_tone0.70360402
169MP0003121_genomic_imprinting0.69376986
170MP0001485_abnormal_pinna_reflex0.68477419
171MP0003936_abnormal_reproductive_system0.68351334
172MP0000358_abnormal_cell_content/0.68330233
173MP0003786_premature_aging0.68035474
174MP0002938_white_spotting0.63337498
175MP0001188_hyperpigmentation0.62562814
176MP0005332_abnormal_amino_acid0.61328947
177MP0008873_increased_physiological_sensi0.61229410
178MP0004134_abnormal_chest_morphology0.61153418

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.39925336
2Rhinitis (HP:0012384)4.95528480
3Abnormal respiratory motile cilium physiology (HP:0012261)4.73866023
4Abnormal respiratory motile cilium morphology (HP:0005938)4.55750088
5Abnormal respiratory epithelium morphology (HP:0012253)4.55750088
6Abnormal ciliary motility (HP:0012262)4.52688673
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.97188373
8Absent/shortened dynein arms (HP:0200106)3.97188373
9Eczematoid dermatitis (HP:0000976)3.81587404
10Myositis (HP:0100614)3.67835152
11Chronic bronchitis (HP:0004469)3.64947209
12Hypochromic microcytic anemia (HP:0004840)3.60363645
13Orchitis (HP:0100796)3.54206133
14Median cleft lip (HP:0000161)3.52857556
15Renal cortical cysts (HP:0000803)3.17902901
16Autoimmune thrombocytopenia (HP:0001973)3.13620560
17Pigmentary retinal degeneration (HP:0001146)3.11071104
18Interstitial pulmonary disease (HP:0006530)3.03614869
19Congenital stationary night blindness (HP:0007642)3.01653245
20Volvulus (HP:0002580)2.98785734
21Dyschromatopsia (HP:0007641)2.96567589
22Oligodactyly (hands) (HP:0001180)2.90529394
23Abnormality of midbrain morphology (HP:0002418)2.90258573
24Molar tooth sign on MRI (HP:0002419)2.90258573
25Bronchiectasis (HP:0002110)2.87445162
26IgM deficiency (HP:0002850)2.82824932
27Recurrent bacterial skin infections (HP:0005406)2.82757886
28Short tibia (HP:0005736)2.82619035
29Bony spicule pigmentary retinopathy (HP:0007737)2.81999370
30Abnormality of the renal cortex (HP:0011035)2.80008931
31Nasal polyposis (HP:0100582)2.79224229
32Recurrent viral infections (HP:0004429)2.79088759
33Hematochezia (HP:0002573)2.74521352
34Pancreatic fibrosis (HP:0100732)2.65933375
35Aplasia/Hypoplasia of the tibia (HP:0005772)2.65701455
36Abnormality of the nasal mucosa (HP:0000433)2.65223257
37Medial flaring of the eyebrow (HP:0010747)2.65152905
38Thrombocytosis (HP:0001894)2.61519879
39Recurrent fungal infections (HP:0002841)2.57946383
40Recurrent abscess formation (HP:0002722)2.57497779
41Increased IgE level (HP:0003212)2.53609770
42Retrobulbar optic neuritis (HP:0100654)2.52934661
43Optic neuritis (HP:0100653)2.52934661
44Pancreatic cysts (HP:0001737)2.52452755
45Elevated erythrocyte sedimentation rate (HP:0003565)2.52414828
46Petechiae (HP:0000967)2.46786867
47Methylmalonic acidemia (HP:0002912)2.44998504
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.41162989
49Supernumerary spleens (HP:0009799)2.38499129
50Hypokinesia (HP:0002375)2.38360890
51True hermaphroditism (HP:0010459)2.37633441
52Abnormality of the prostate (HP:0008775)2.37242967
53Hypoplastic labia majora (HP:0000059)2.37043235
54Recurrent gram-negative bacterial infections (HP:0005420)2.36487430
55Osteolytic defects of the hand bones (HP:0009699)2.35833055
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.35833055
57Periodontitis (HP:0000704)2.35797390
58Infertility (HP:0000789)2.35428905
59Male infertility (HP:0003251)2.35128509
60Villous atrophy (HP:0011473)2.32862265
61Abnormality of small intestinal villus morphology (HP:0011472)2.32862265
62Pili torti (HP:0003777)2.32284371
63Abnormality of the fingertips (HP:0001211)2.31978844
64Posterior subcapsular cataract (HP:0007787)2.27639206
65Congenital primary aphakia (HP:0007707)2.27062174
66Azoospermia (HP:0000027)2.25180929
67Tubulointerstitial nephritis (HP:0001970)2.24637665
68Chronic diarrhea (HP:0002028)2.24492706
69Abnormality of T cell physiology (HP:0011840)2.23086051
70Acute myeloid leukemia (HP:0004808)2.23056703
71Hypoglycemic coma (HP:0001325)2.22767437
72Chorioretinal atrophy (HP:0000533)2.22157901
73Degeneration of anterior horn cells (HP:0002398)2.20692534
74Abnormality of the anterior horn cell (HP:0006802)2.20692534
75Osteomyelitis (HP:0002754)2.19887930
76Metaphyseal dysplasia (HP:0100255)2.19633355
77Micronodular cirrhosis (HP:0001413)2.19504494
78Congenital, generalized hypertrichosis (HP:0004540)2.18211074
79Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17259320
80Progressive macrocephaly (HP:0004481)2.17203443
81Genital tract atresia (HP:0001827)2.17124962
82Gait imbalance (HP:0002141)2.16709599
83Arterial thrombosis (HP:0004420)2.16559981
84Reduced antithrombin III activity (HP:0001976)2.16215335
85Keratoconjunctivitis sicca (HP:0001097)2.13587228
86Popliteal pterygium (HP:0009756)2.13083616
87Absent frontal sinuses (HP:0002688)2.12569934
88Cutaneous melanoma (HP:0012056)2.11295999
89Vasculitis (HP:0002633)2.10569641
90Abnormality of chloride homeostasis (HP:0011422)2.10042000
91Abnormality of the labia majora (HP:0012881)2.09890193
92Eosinophilia (HP:0001880)2.06949816
93Abnormal platelet function (HP:0011869)2.06296657
94Impaired platelet aggregation (HP:0003540)2.06296657
95Acute necrotizing encephalopathy (HP:0006965)2.05919683
96Recurrent bronchitis (HP:0002837)2.05839087
97Abnormal auditory evoked potentials (HP:0006958)2.05025636
98Nephrogenic diabetes insipidus (HP:0009806)2.04768512
99Keratoconjunctivitis (HP:0001096)2.04603477
100Abnormal rod and cone electroretinograms (HP:0008323)2.04492028
101Abnormality of aspartate family amino acid metabolism (HP:0010899)2.03528897
102Chronic hepatic failure (HP:0100626)2.02834367
103Spontaneous hematomas (HP:0007420)2.02751272
104Abnormality of the intrinsic pathway (HP:0010989)2.01358036
105Pendular nystagmus (HP:0012043)1.99967768
106Abnormality of macrophages (HP:0004311)1.99838176
107Proximal tubulopathy (HP:0000114)1.98077725
108Abnormality of methionine metabolism (HP:0010901)1.97759492
109Aplasia/Hypoplasia of the fovea (HP:0008060)1.97106659
110Hypoplasia of the fovea (HP:0007750)1.97106659
111Hypochromic anemia (HP:0001931)1.95070348
112Abnormal spermatogenesis (HP:0008669)1.94925214
113Blepharitis (HP:0000498)1.94680744
114Vacuolated lymphocytes (HP:0001922)1.93777094
115Abnormality of glutamine family amino acid metabolism (HP:0010902)1.93294322
116Abnormal biliary tract morphology (HP:0012440)1.93073235
117Nephronophthisis (HP:0000090)1.92796436
118Fair hair (HP:0002286)1.92795711
119Combined immunodeficiency (HP:0005387)1.92141248
120Degeneration of the lateral corticospinal tracts (HP:0002314)1.92045695
121Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92045695
122Prostate neoplasm (HP:0100787)1.91073085
123Spinal cord lesions (HP:0100561)1.90914862
124Syringomyelia (HP:0003396)1.90914862
125Cheilitis (HP:0100825)1.90549431
126Abnormality of the renal medulla (HP:0100957)1.90328819
127Vaginal atresia (HP:0000148)1.89403583
128Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.88929752
129Pustule (HP:0200039)1.88141693
130Thyroiditis (HP:0100646)1.87814476
131IgA deficiency (HP:0002720)1.87221714
132Abnormality of the fovea (HP:0000493)1.87218851
133Increased CSF protein (HP:0002922)1.85969610
134Right ventricular cardiomyopathy (HP:0011663)1.85872476
135Multiple enchondromatosis (HP:0005701)1.85848722
136Gingivitis (HP:0000230)1.85583230
137Encephalitis (HP:0002383)1.85540158
138Abnormality of purine metabolism (HP:0004352)1.85370989
139Increased hepatocellular lipid droplets (HP:0006565)1.84926148
140Pulmonary infiltrates (HP:0002113)1.84433068
141Patchy hypopigmentation of hair (HP:0011365)1.83934741
142Abnormal hemoglobin (HP:0011902)1.83906502
143Thyroid carcinoma (HP:0002890)1.83039234
144Gonadotropin excess (HP:0000837)1.82915271
145Labial hypoplasia (HP:0000066)1.82863665
146Hypothermia (HP:0002045)1.82789053
147Gingival bleeding (HP:0000225)1.82733509
148Spinal muscular atrophy (HP:0007269)1.82454143
149Milia (HP:0001056)1.82434399
150B lymphocytopenia (HP:0010976)1.82003045
151Abnormality of B cell number (HP:0010975)1.82003045
152Subacute progressive viral hepatitis (HP:0006572)1.81743111
153Postaxial hand polydactyly (HP:0001162)1.81233230
154Abnormality of renal resorption (HP:0011038)1.80472369
155Polyneuropathy (HP:0001271)1.80320959
156Autoimmune hemolytic anemia (HP:0001890)1.79879167
157Vascular calcification (HP:0004934)1.79759693
158Hydroxyprolinuria (HP:0003080)1.79563675
159Abnormality of proline metabolism (HP:0010907)1.79563675
160Granulocytopenia (HP:0001913)1.79439354
161Bifid tongue (HP:0010297)1.79404611
162Papillary thyroid carcinoma (HP:0002895)1.79242886
163Lip pit (HP:0100267)1.78742901
164Bronchitis (HP:0012387)1.77464185
165Cellulitis (HP:0100658)1.76829843
166Abnormality of placental membranes (HP:0011409)1.76588621
167Amniotic constriction ring (HP:0009775)1.76588621
168Abnormality of eosinophils (HP:0001879)1.76500656
169Generalized hypopigmentation of hair (HP:0011358)1.76318570
170Abnormal platelet volume (HP:0011876)1.76007709
171Leukocytosis (HP:0001974)1.75985727
172Hyperactive renin-angiotensin system (HP:0000841)1.75903209
173Macular degeneration (HP:0000608)1.74808464
174Chronic otitis media (HP:0000389)1.74742122
175Biliary tract neoplasm (HP:0100574)1.73176732
176Male pseudohermaphroditism (HP:0000037)1.72190931
177Steatorrhea (HP:0002570)1.70930781
178Cone-rod dystrophy (HP:0000548)1.70695918
179Hypoplastic female external genitalia (HP:0012815)1.68644157
180Abnormality of the septum pellucidum (HP:0007375)1.67319677
1813-Methylglutaconic aciduria (HP:0003535)1.66703718
182Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66681300
183Absent septum pellucidum (HP:0001331)1.66282129
184Abnormal mitochondria in muscle tissue (HP:0008316)1.64920860
185Intrahepatic cholestasis (HP:0001406)1.64906189
186Renal Fanconi syndrome (HP:0001994)1.64645497
187Lipid accumulation in hepatocytes (HP:0006561)1.64575007
188Abnormality of vitamin B metabolism (HP:0004340)1.64472434
189Congenital ichthyosiform erythroderma (HP:0007431)1.63430949
190Oculomotor apraxia (HP:0000657)1.62853312
191Neuroendocrine neoplasm (HP:0100634)1.62399404
192Glycosuria (HP:0003076)1.61687084
193Abnormality of urine glucose concentration (HP:0011016)1.61687084

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.23741576
2MAP3K123.75743140
3CDK123.64372367
4TRIM283.26051994
5ERN13.02670062
6TAOK32.99266442
7STK102.67799606
8BCR2.41648684
9MST42.37798479
10MAP3K142.33610766
11GRK12.19843945
12GRK62.03347025
13MST1R1.95952056
14FGFR31.93216853
15BMPR1B1.93161709
16RIPK11.89745997
17MET1.84512668
18MATK1.84436416
19KIT1.77350642
20STK38L1.76535060
21TYK21.70415392
22NUAK11.62084945
23STK391.56240997
24TGFBR21.55600526
25NEK11.54617245
26TEC1.51510186
27IRAK31.51245066
28PLK21.46324920
29TTK1.44418120
30JAK31.41908217
31STK31.38992035
32STK241.38815462
33TXK1.37602467
34NEK61.34059016
35SIK31.33649124
36TBK11.32358119
37MAP3K91.32089627
38TNIK1.31240796
39JAK11.29230599
40EPHA21.29197107
41BMPR21.28810470
42MAP4K21.27207825
43PAK31.26301932
44MAP4K11.25593209
45EIF2AK11.24248023
46PBK1.23107614
47PNCK1.21340823
48WNK31.21067669
49PIM21.20330085
50PIM11.19268002
51ITK1.18561888
52ERBB41.18274460
53CDK61.17850260
54CSF1R1.16728610
55FER1.16580675
56FGFR41.16348555
57IKBKE1.13721741
58MAPK131.10339627
59CASK1.10102087
60IRAK41.06776457
61PTK61.06773660
62WEE11.06531078
63RPS6KA41.05560218
64OXSR11.04614610
65PDK41.03377967
66PDK31.03377967
67NEK91.01924512
68MUSK1.01153174
69KSR10.99462778
70BRSK20.99353373
71PDK20.96434511
72PRKG20.95274211
73EPHB10.94946680
74CSK0.92288373
75PINK10.92230590
76EPHA30.91399413
77BTK0.90920674
78MAPKAPK30.90536027
79TRPM70.90493507
80TESK10.90222615
81LRRK20.88747365
82STK40.88242399
83IKBKB0.87455088
84MAPK70.86954314
85CSNK1G20.85865723
86DMPK0.85073150
87PRKCE0.84209018
88LATS10.83170188
89LIMK10.82997318
90* CHUK0.81596576
91LMTK20.80607345
92MINK10.79595067
93NEK20.77935046
94ZAP700.75576749
95WNK10.73490611
96SRPK10.72833436
97PIK3CG0.72803077
98ACVR1B0.70145069
99AURKB0.69023275
100CSNK1G10.68571818
101ZAK0.67561083
102PAK40.67248998
103RPS6KB20.66758162
104PRKCI0.66394091
105GRK50.65633198
106MAP2K60.65602805
107HIPK20.64148332
108JAK20.62230425
109RIPK40.62064246
110CSNK1G30.61584053
111CDC70.60974674
112MAP3K40.60974228
113MARK30.60234656
114MAP2K30.60140485
115MAPK150.58915593
116ERBB30.58604212
117CSNK1A1L0.58400824
118SCYL20.56302174
119NLK0.56251670
120CAMK2D0.54918499
121ROCK10.54685786
122LCK0.53699210
123MAP2K70.53281127
124STK160.53184061
125CAMK2A0.52216663
126EEF2K0.49031974
127SYK0.48567433
128DYRK1B0.47031543
129FLT30.45724274
130MYLK0.45293190
131TGFBR10.45176858
132MAP3K50.44372494
133MAP3K80.43713451
134CDK90.43295766
135PIK3CA0.43255035
136MAPKAPK20.42242993
137PLK10.41697255
138AKT30.41082922
139MAP3K30.41006262
140ROCK20.40353565
141IGF1R0.40028859
142NTRK30.39820355
143INSRR0.39109632
144ATM0.38899739
145WNK40.38563593
146ATR0.38049180
147MOS0.37767180
148EIF2AK20.35711098
149ARAF0.35228755
150EGFR0.35149645
151PRKG10.34728344
152PRKD30.34668885
153PRKACB0.34214874
154PLK30.34071069
155CAMKK20.33751338
156MAP3K20.33589993
157PTK20.33491677
158CSNK1E0.33148421
159MAP3K130.31873531
160CDK70.31620860
161ILK0.31519696
162LATS20.31295940
163ABL10.31137063
164MAPK40.30780930
165EIF2AK30.30780619
166YES10.29461756

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.90630861
2Proteasome_Homo sapiens_hsa030503.89204221
3Circadian rhythm_Homo sapiens_hsa047102.65702183
4Oxidative phosphorylation_Homo sapiens_hsa001902.64594692
5Phototransduction_Homo sapiens_hsa047442.55373348
6Propanoate metabolism_Homo sapiens_hsa006402.48997272
7Basal transcription factors_Homo sapiens_hsa030222.42477484
8Caffeine metabolism_Homo sapiens_hsa002322.23789034
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14482089
10Leishmaniasis_Homo sapiens_hsa051402.10500725
11Collecting duct acid secretion_Homo sapiens_hsa049662.09271015
12Fatty acid elongation_Homo sapiens_hsa000622.01509199
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.95736125
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.83369653
15Parkinsons disease_Homo sapiens_hsa050121.79775430
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.79577561
17Galactose metabolism_Homo sapiens_hsa000521.78632733
18Huntingtons disease_Homo sapiens_hsa050161.77645203
19Regulation of autophagy_Homo sapiens_hsa041401.75651610
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.75410818
21Renin-angiotensin system_Homo sapiens_hsa046141.73903091
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.73356258
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.73124412
24Toxoplasmosis_Homo sapiens_hsa051451.65716276
25Antigen processing and presentation_Homo sapiens_hsa046121.64153287
26Legionellosis_Homo sapiens_hsa051341.61333000
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.57594414
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.55442678
29beta-Alanine metabolism_Homo sapiens_hsa004101.55079969
30Vitamin B6 metabolism_Homo sapiens_hsa007501.54038209
31RNA degradation_Homo sapiens_hsa030181.49201825
32Influenza A_Homo sapiens_hsa051641.42467178
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41832790
34Alzheimers disease_Homo sapiens_hsa050101.40043847
35Oocyte meiosis_Homo sapiens_hsa041141.39679022
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36263052
37Vibrio cholerae infection_Homo sapiens_hsa051101.36019356
38Sulfur metabolism_Homo sapiens_hsa009201.34874508
39Herpes simplex infection_Homo sapiens_hsa051681.34480096
40Vitamin digestion and absorption_Homo sapiens_hsa049771.33270095
41Measles_Homo sapiens_hsa051621.31615580
42Fructose and mannose metabolism_Homo sapiens_hsa000511.29564653
43Steroid biosynthesis_Homo sapiens_hsa001001.27953125
44ABC transporters_Homo sapiens_hsa020101.26983997
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.25761791
46Mineral absorption_Homo sapiens_hsa049781.24975236
47Osteoclast differentiation_Homo sapiens_hsa043801.24674251
48Hepatitis C_Homo sapiens_hsa051601.23956989
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23702898
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23670042
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.23071712
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.22061516
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17961748
54TNF signaling pathway_Homo sapiens_hsa046681.17793428
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.17313477
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.15256652
57Other glycan degradation_Homo sapiens_hsa005111.14696429
58Nucleotide excision repair_Homo sapiens_hsa034201.13888646
59Hematopoietic cell lineage_Homo sapiens_hsa046401.13213228
60Starch and sucrose metabolism_Homo sapiens_hsa005001.11413150
61Mismatch repair_Homo sapiens_hsa034301.09359980
62Tuberculosis_Homo sapiens_hsa051521.09305866
63Apoptosis_Homo sapiens_hsa042101.06930286
64Arachidonic acid metabolism_Homo sapiens_hsa005901.05152215
65Fatty acid degradation_Homo sapiens_hsa000711.04064436
66Primary bile acid biosynthesis_Homo sapiens_hsa001201.03295366
67Small cell lung cancer_Homo sapiens_hsa052221.02543623
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01823578
69Pertussis_Homo sapiens_hsa051331.01720209
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01069514
71Fat digestion and absorption_Homo sapiens_hsa049751.00150130
72B cell receptor signaling pathway_Homo sapiens_hsa046620.99775747
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99295498
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98445396
75Tryptophan metabolism_Homo sapiens_hsa003800.95782444
76Sphingolipid metabolism_Homo sapiens_hsa006000.95567697
77Primary immunodeficiency_Homo sapiens_hsa053400.95403742
78Non-homologous end-joining_Homo sapiens_hsa034500.94903894
79Cardiac muscle contraction_Homo sapiens_hsa042600.94347348
80p53 signaling pathway_Homo sapiens_hsa041150.93620292
81Retinol metabolism_Homo sapiens_hsa008300.92723914
82Histidine metabolism_Homo sapiens_hsa003400.91394644
83PPAR signaling pathway_Homo sapiens_hsa033200.90611152
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89989886
85Glycerolipid metabolism_Homo sapiens_hsa005610.89098797
86Lysosome_Homo sapiens_hsa041420.86773073
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86109689
88Pentose phosphate pathway_Homo sapiens_hsa000300.85554993
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85110440
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84722817
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.84668496
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84347690
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84092633
94Thyroid cancer_Homo sapiens_hsa052160.83725734
95Homologous recombination_Homo sapiens_hsa034400.83723332
96Butanoate metabolism_Homo sapiens_hsa006500.83506548
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82933254
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81975761
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80624926
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80544644
101Hepatitis B_Homo sapiens_hsa051610.78585302
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.78132145
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78115741
104Linoleic acid metabolism_Homo sapiens_hsa005910.77605482
105Synaptic vesicle cycle_Homo sapiens_hsa047210.77323506
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76115453
107Pyruvate metabolism_Homo sapiens_hsa006200.75044407
108Pancreatic cancer_Homo sapiens_hsa052120.74925892
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74721618
110RNA polymerase_Homo sapiens_hsa030200.72411802
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69587768
112Selenocompound metabolism_Homo sapiens_hsa004500.69253651
113Acute myeloid leukemia_Homo sapiens_hsa052210.69227674
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69132013
115Complement and coagulation cascades_Homo sapiens_hsa046100.69100430
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67616597
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.67144826
118Insulin resistance_Homo sapiens_hsa049310.67077701
119Chemical carcinogenesis_Homo sapiens_hsa052040.66983808
120Staphylococcus aureus infection_Homo sapiens_hsa051500.65964212
121Salmonella infection_Homo sapiens_hsa051320.65930888
122Tyrosine metabolism_Homo sapiens_hsa003500.65475037
123Viral carcinogenesis_Homo sapiens_hsa052030.64879368
124Peroxisome_Homo sapiens_hsa041460.64493645
125Malaria_Homo sapiens_hsa051440.64318857
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.64103169
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63945898
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63607432
129Tight junction_Homo sapiens_hsa045300.62950529
130Nitrogen metabolism_Homo sapiens_hsa009100.62512756
131Prolactin signaling pathway_Homo sapiens_hsa049170.60122914
132RNA transport_Homo sapiens_hsa030130.59747482
133TGF-beta signaling pathway_Homo sapiens_hsa043500.59172772
134Folate biosynthesis_Homo sapiens_hsa007900.57944944
135Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57370310
136Cell cycle_Homo sapiens_hsa041100.56826431
137Fatty acid biosynthesis_Homo sapiens_hsa000610.55884276
138Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55224714
139Fatty acid metabolism_Homo sapiens_hsa012120.54620108
140Platelet activation_Homo sapiens_hsa046110.54373025
141Metabolic pathways_Homo sapiens_hsa011000.53921210
142Bile secretion_Homo sapiens_hsa049760.53683260
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.53425133
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53198054
145Fanconi anemia pathway_Homo sapiens_hsa034600.53112557
146Dorso-ventral axis formation_Homo sapiens_hsa043200.52863384
147Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51700421
148Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48884630
149Inositol phosphate metabolism_Homo sapiens_hsa005620.48428261
150Shigellosis_Homo sapiens_hsa051310.48222274
151Glutathione metabolism_Homo sapiens_hsa004800.47706688
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47047164
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46143973
154Epstein-Barr virus infection_Homo sapiens_hsa051690.45523222
155Phagosome_Homo sapiens_hsa041450.45462070
156Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45335745
157Pancreatic secretion_Homo sapiens_hsa049720.38270755
158Adherens junction_Homo sapiens_hsa045200.37736972
159Ovarian steroidogenesis_Homo sapiens_hsa049130.37486306
160Olfactory transduction_Homo sapiens_hsa047400.35216192
161Purine metabolism_Homo sapiens_hsa002300.33337000
162Phenylalanine metabolism_Homo sapiens_hsa003600.31734455
163Dopaminergic synapse_Homo sapiens_hsa047280.31676346
164Hippo signaling pathway_Homo sapiens_hsa043900.29778382
165Rheumatoid arthritis_Homo sapiens_hsa053230.28228791
166Endocytosis_Homo sapiens_hsa041440.25386422

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