TBATA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that regulates thymic epithelial cell proliferation and thymus size. It has been identified as a ligand for the class I human leukocyte antigen (HLA-I) in thymus. Studies of the orthologous mouse protein suggest that it may also play a role in spermatid differentiation, as well as in neuronal morphogenesis and synaptic plasticity. Polymorphisms in this gene are associated with susceptibility for multiple sclerosis (MS). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.74121536
2chromosome condensation (GO:0030261)9.33098754
3DNA packaging (GO:0006323)9.11768857
4spermatid development (GO:0007286)8.47216666
5single strand break repair (GO:0000012)8.27444851
6spermatid nucleus differentiation (GO:0007289)8.20216568
7response to pheromone (GO:0019236)8.20085909
8positive regulation of protein kinase C signaling (GO:0090037)8.18694228
9microtubule depolymerization (GO:0007019)8.12541034
10sperm-egg recognition (GO:0035036)7.36970060
11protein polyglutamylation (GO:0018095)7.26814913
12rRNA methylation (GO:0031167)7.20313431
13phosphatidylethanolamine biosynthetic process (GO:0006646)6.97438872
14protein targeting to Golgi (GO:0000042)6.88622978
15sexual reproduction (GO:0019953)6.88191645
16reproduction (GO:0000003)6.78886316
17negative regulation of inclusion body assembly (GO:0090084)6.76941928
18microtubule polymerization or depolymerization (GO:0031109)6.68130901
19establishment of protein localization to Golgi (GO:0072600)6.62315600
20binding of sperm to zona pellucida (GO:0007339)6.61958355
21calcium ion-dependent exocytosis (GO:0017156)6.53174347
22retrograde transport, vesicle recycling within Golgi (GO:0000301)6.43216441
23phosphatidylethanolamine metabolic process (GO:0046337)6.42506476
24microtubule severing (GO:0051013)6.26290046
25cell-cell recognition (GO:0009988)6.08820914
26rRNA modification (GO:0000154)6.04193960
27* spermatogenesis (GO:0007283)5.97732589
28* male gamete generation (GO:0048232)5.95608877
29GMP metabolic process (GO:0046037)5.65142556
30antigen processing and presentation of endogenous antigen (GO:0019883)5.64135951
31* gamete generation (GO:0007276)5.45390125
32regulation of cilium movement (GO:0003352)5.44838281
33regulation of protein kinase A signaling (GO:0010738)5.41131062
34cellular ketone body metabolic process (GO:0046950)5.26192950
35regulation of protein kinase C signaling (GO:0090036)5.18985735
36regulation of Rab GTPase activity (GO:0032313)5.18496123
37positive regulation of Rab GTPase activity (GO:0032851)5.18496123
38melanin biosynthetic process (GO:0042438)5.13578107
39regulation of dendritic cell antigen processing and presentation (GO:0002604)5.13241801
40melanin metabolic process (GO:0006582)5.10866944
41RNA destabilization (GO:0050779)5.02541094
42regulation of T-helper 1 cell differentiation (GO:0045625)4.97090326
43single fertilization (GO:0007338)4.94702151
44protein localization to Golgi apparatus (GO:0034067)4.89815240
45regulation of inclusion body assembly (GO:0090083)4.85790803
46positive regulation of antigen processing and presentation (GO:0002579)4.85610996
47regulation of transcription involved in cell fate commitment (GO:0060850)4.79254371
48cilium or flagellum-dependent cell motility (GO:0001539)4.75751247
49germ cell development (GO:0007281)4.72727942
50ketone body metabolic process (GO:1902224)4.63346983
51regulation of antigen processing and presentation (GO:0002577)4.60510361
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.60241831
53cellular process involved in reproduction in multicellular organism (GO:0022412)4.50169241
54UV protection (GO:0009650)4.50067466
55chromatin silencing (GO:0006342)4.40141766
56regulation of centriole replication (GO:0046599)4.38885851
57* multicellular organismal reproductive process (GO:0048609)4.38617123
58presynaptic membrane assembly (GO:0097105)4.38001066
59nucleus organization (GO:0006997)4.32243557
60secondary metabolite biosynthetic process (GO:0044550)4.26907880
61negative regulation of execution phase of apoptosis (GO:1900118)4.22530164
62mannose metabolic process (GO:0006013)4.14054090
63fertilization (GO:0009566)4.12519441
64ribosomal small subunit biogenesis (GO:0042274)4.06381756
65cellular response to type I interferon (GO:0071357)4.03739291
66type I interferon signaling pathway (GO:0060337)4.03739291
67response to type I interferon (GO:0034340)4.02526524
68antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00795717
69seminiferous tubule development (GO:0072520)4.00639224
70postsynaptic membrane organization (GO:0001941)3.98772013
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.96704328
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.96704328
73regulation of microtubule-based movement (GO:0060632)3.93650906
74presynaptic membrane organization (GO:0097090)3.92479486
75multicellular organismal movement (GO:0050879)3.89941859
76musculoskeletal movement (GO:0050881)3.89941859
77organic cation transport (GO:0015695)3.88162545
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.86686345
79response to acidic pH (GO:0010447)3.84509274
80viral transcription (GO:0019083)3.77973651
81imidazole-containing compound metabolic process (GO:0052803)3.75719789
82cellular response to exogenous dsRNA (GO:0071360)3.71828839
83positive regulation of monocyte chemotaxis (GO:0090026)3.65248476
84coenzyme catabolic process (GO:0009109)3.65199640
85superoxide anion generation (GO:0042554)3.64375618
86immunoglobulin mediated immune response (GO:0016064)3.64002741
87polyamine biosynthetic process (GO:0006596)3.58868948
88cilium movement (GO:0003341)3.56531917
89negative regulation of viral genome replication (GO:0045071)3.54488048
90glycogen catabolic process (GO:0005980)3.52255444
91fusion of sperm to egg plasma membrane (GO:0007342)3.52169674
92regulation of interleukin-13 production (GO:0032656)3.51239391
93peptidyl-threonine dephosphorylation (GO:0035970)3.50164235
94membrane protein intracellular domain proteolysis (GO:0031293)3.48714487
95negative regulation of Rho protein signal transduction (GO:0035024)3.46911034
96positive regulation of T-helper 1 type immune response (GO:0002827)3.45965246
97cellular response to pH (GO:0071467)3.44317651
98myeloid dendritic cell differentiation (GO:0043011)3.42262857
99positive regulation of T-helper cell differentiation (GO:0045624)3.39958726
100cerebral cortex neuron differentiation (GO:0021895)3.39177432
101eyelid development in camera-type eye (GO:0061029)3.37522548
102translational termination (GO:0006415)3.37103529
103regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.37101773
104adhesion of symbiont to host cell (GO:0044650)3.36511866
105virion attachment to host cell (GO:0019062)3.36511866
106protein-DNA complex disassembly (GO:0032986)3.35893283
107nucleosome disassembly (GO:0006337)3.35893283
108positive regulation of granulocyte chemotaxis (GO:0071624)3.35801490
109sperm motility (GO:0030317)3.35790637
110glycerol ether metabolic process (GO:0006662)3.35124927
111homeostasis of number of cells within a tissue (GO:0048873)3.33222821
112NIK/NF-kappaB signaling (GO:0038061)3.32536610
113response to interferon-alpha (GO:0035455)3.28487086
114glucan catabolic process (GO:0009251)3.26462967
115regulation of T-helper 2 cell differentiation (GO:0045628)3.24990292
116microtubule nucleation (GO:0007020)3.19721671
117cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.18362730
118negative regulation of tumor necrosis factor production (GO:0032720)3.17612220
119regulation of somitogenesis (GO:0014807)3.14711644
120bundle of His cell to Purkinje myocyte communication (GO:0086069)3.14595172
121myeloid dendritic cell activation (GO:0001773)3.11067193
122regulation of cellular extravasation (GO:0002691)3.10477980
123ether metabolic process (GO:0018904)3.08276601
124histone H3-K9 demethylation (GO:0033169)3.08258273
125dendritic cell differentiation (GO:0097028)3.06726737
126negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.06099519
127negative regulation of nitric oxide biosynthetic process (GO:0045019)3.05525553
128facial nerve structural organization (GO:0021612)3.04503629
129response to interferon-beta (GO:0035456)3.03118496
130protein depolymerization (GO:0051261)3.02642279
131negative regulation of gene expression, epigenetic (GO:0045814)3.01693363
132* multicellular organismal development (GO:0007275)2.99919827
133Golgi to endosome transport (GO:0006895)2.98881271
134mRNA modification (GO:0016556)2.97957677
135glomerular visceral epithelial cell development (GO:0072015)2.97686868
136oxygen transport (GO:0015671)2.95949120
137short-term memory (GO:0007614)2.95772916
138regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)2.95262662
139pattern specification involved in kidney development (GO:0061004)2.93474153
140regulation of phosphoprotein phosphatase activity (GO:0043666)2.93292723
141response to folic acid (GO:0051593)2.91347837
142cellular polysaccharide catabolic process (GO:0044247)2.91211261
143negative regulation of myeloid cell apoptotic process (GO:0033033)2.91196977
144cranial nerve morphogenesis (GO:0021602)2.90647444
145DNA conformation change (GO:0071103)2.90275620
146glomerular epithelial cell development (GO:0072310)2.89722937
147cell recognition (GO:0008037)2.89107909
148hemidesmosome assembly (GO:0031581)2.88558948
149mesenchymal cell differentiation involved in kidney development (GO:0072161)2.87367587
150mesenchymal cell differentiation involved in renal system development (GO:2001012)2.87367587
151mitochondrial fission (GO:0000266)2.85844562
152positive regulation of calcium ion import (GO:0090280)2.85636507
153mitotic G1 DNA damage checkpoint (GO:0031571)2.83762367
154regulation of ARF GTPase activity (GO:0032312)2.82817727
155B cell mediated immunity (GO:0019724)2.82760690
156positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.81317270
157regulation of ruffle assembly (GO:1900027)2.80051810
158acrosome assembly (GO:0001675)2.78249507
159polysaccharide catabolic process (GO:0000272)2.77896733
160protein targeting to ER (GO:0045047)2.77136849
161SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.75821505
162interferon-gamma-mediated signaling pathway (GO:0060333)2.75293853
163cellular response to virus (GO:0098586)2.75171218
164cell wall macromolecule metabolic process (GO:0044036)2.73832248
165cell wall macromolecule catabolic process (GO:0016998)2.73832248
166positive regulation of guanylate cyclase activity (GO:0031284)2.73623135
167centriole replication (GO:0007099)2.73402892
168cotranslational protein targeting to membrane (GO:0006613)2.72249461
169multicellular organism reproduction (GO:0032504)2.71980424
170positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.69517874
171motile cilium assembly (GO:0044458)2.69337486
172positive regulation of response to cytokine stimulus (GO:0060760)2.68429784
173DNA methylation involved in gamete generation (GO:0043046)2.68164428
174epithelial cilium movement (GO:0003351)2.67787711
175regulation of monocyte chemotaxis (GO:0090025)2.67363665
176axonemal dynein complex assembly (GO:0070286)2.67181196
177negative regulation of histone methylation (GO:0031061)2.65672245
178centrosome duplication (GO:0051298)2.65479806
179positive regulation of Cdc42 GTPase activity (GO:0043089)2.63971382
180acrosome reaction (GO:0007340)2.63691588
181centriole assembly (GO:0098534)2.60882448
182regulation of monocyte differentiation (GO:0045655)2.60492650
183ribosomal small subunit assembly (GO:0000028)2.60440222
184regulation of granulocyte chemotaxis (GO:0071622)2.60234981
185establishment of protein localization to endoplasmic reticulum (GO:0072599)2.59426414
186mature B cell differentiation (GO:0002335)2.57532354
187negative regulation of leukocyte apoptotic process (GO:2000107)2.57146581
188plasma membrane fusion (GO:0045026)2.56719955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.65392677
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.92653727
3EZH2_22144423_ChIP-Seq_EOC_Human3.86326373
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.50836261
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.22125591
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15091312
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.13470013
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.56674261
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.40296760
10TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40296760
11VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.26088610
12CBP_20019798_ChIP-Seq_JUKART_Human2.17248790
13IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.17248790
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14951387
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.14087547
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13409425
17ELF1_20517297_ChIP-Seq_JURKAT_Human2.12152638
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.09470840
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09017507
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.03286365
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02413208
22DROSHA_22980978_ChIP-Seq_HELA_Human1.96526520
23ERA_21632823_ChIP-Seq_H3396_Human1.89794919
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.89204102
25RAC3_21632823_ChIP-Seq_H3396_Human1.87590228
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87322126
27RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.85971525
28EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.85576606
29CTCF_27219007_Chip-Seq_Bcells_Human1.82566741
30NANOG_20526341_ChIP-Seq_ESCs_Human1.81290423
31WDR5_24793694_ChIP-Seq_LNCAP_Human1.80956653
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.80139177
33EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.77263832
34FUS_26573619_Chip-Seq_HEK293_Human1.74043340
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.73140277
36BCL6_27268052_Chip-Seq_Bcells_Human1.72671632
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72557318
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69960951
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65859602
40SMC4_20622854_ChIP-Seq_HELA_Human1.65104764
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.64022334
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.63233875
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62523388
44VDR_22108803_ChIP-Seq_LS180_Human1.62465175
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61901179
46BCOR_27268052_Chip-Seq_Bcells_Human1.61365031
47TAF2_19829295_ChIP-Seq_ESCs_Human1.61014992
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59946699
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58528191
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.58524952
51E2F1_20622854_ChIP-Seq_HELA_Human1.58378055
52YY1_22570637_ChIP-Seq_MALME-3M_Human1.58281770
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.57419542
54P68_20966046_ChIP-Seq_HELA_Human1.55446621
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54345559
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.54175193
57PHF8_20622854_ChIP-Seq_HELA_Human1.54080475
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.53321266
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53051070
60MYC_19829295_ChIP-Seq_ESCs_Human1.51448722
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.51428543
62CTCF_20526341_ChIP-Seq_ESCs_Human1.51291790
63LXR_22292898_ChIP-Seq_THP-1_Human1.50863985
64OCT4_20526341_ChIP-Seq_ESCs_Human1.50323155
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49194234
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49173307
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49173307
68TP63_22573176_ChIP-Seq_HFKS_Human1.48688859
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.47329815
70PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47109963
71SMAD4_21741376_ChIP-Seq_EPCs_Human1.46476924
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.45737219
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.45669344
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45663359
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39810266
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39720752
77AR_25329375_ChIP-Seq_VCAP_Human1.39257991
78HNFA_21074721_ChIP-Seq_CACO-2_Human1.38751010
79ERG_20517297_ChIP-Seq_VCAP_Human1.38317622
80P300_27268052_Chip-Seq_Bcells_Human1.38074479
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37865146
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37649331
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.36116214
84RBPJ_21746931_ChIP-Seq_IB4_Human1.35831768
85CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.34577526
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.33691882
87CBX2_22325352_ChIP-Seq_293T-Rex_Human1.32920183
88P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.31515585
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30588168
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30469517
91SMAD3_21741376_ChIP-Seq_ESCs_Human1.28616313
92CDX2_20551321_ChIP-Seq_CACO-2_Human1.28004180
93ETV1_20927104_ChIP-Seq_GIST48_Human1.27562290
94CEBPB_22108803_ChIP-Seq_LS180_Human1.27525144
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27321805
96STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26747120
97SOX2_22085726_ChIP-Seq_NPCs_Mouse1.23084768
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21775728
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.21719854
100GATA3_21878914_ChIP-Seq_MCF-7_Human1.20990763
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20647386
102VDR_24787735_ChIP-Seq_THP-1_Human1.20363486
103RUNX_20019798_ChIP-Seq_JUKART_Human1.19070151
104NFYB_21822215_ChIP-Seq_K562_Human1.18632533
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18352906
106RUNX1_26923725_Chip-Seq_HPCs_Mouse1.17885732
107CBX2_27304074_Chip-Seq_ESCs_Mouse1.17822992
108RNF2_27304074_Chip-Seq_NSC_Mouse1.16921043
109TP63_19390658_ChIP-ChIP_HaCaT_Human1.16828531
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16092043
111LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15314604
112SMRT_27268052_Chip-Seq_Bcells_Human1.14241954
113TBL1_22424771_ChIP-Seq_293T_Human1.13931602
114P53_21459846_ChIP-Seq_SAOS-2_Human1.13790482
115SA1_27219007_Chip-Seq_Bcells_Human1.13507350
116P300_19829295_ChIP-Seq_ESCs_Human1.12237639
117KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11144214
118KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11144214
119KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11144214
120TAF15_26573619_Chip-Seq_HEK293_Human1.10958126
121GATA6_21074721_ChIP-Seq_CACO-2_Human1.10313601
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.09449009
123PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09297729
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08861929
125PHF8_20622853_ChIP-Seq_HELA_Human1.08860588
126* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07577098
127NMYC_18555785_Chip-Seq_ESCs_Mouse1.07071514
128GATA2_21666600_ChIP-Seq_HMVEC_Human1.06162130
129STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05829463
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05712753
131ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05301772
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04364777
133SMAD4_21741376_ChIP-Seq_HESCs_Human1.04107678
134NFYA_21822215_ChIP-Seq_K562_Human1.03681013
135P300_18555785_Chip-Seq_ESCs_Mouse1.02939770
136TP53_18474530_ChIP-ChIP_U2OS_Human1.02767946
137ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02702711
138PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02500507
139PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02119095
140RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01352228
141KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00838214
142KLF5_25053715_ChIP-Seq_YYC3_Human1.00788114
143BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00699313
144GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00036151
145CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99994060
146BCAT_22108803_ChIP-Seq_LS180_Human0.99570722
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99149773
148RUNX2_22187159_ChIP-Seq_PCA_Human0.98815134
149TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98077648
150SA1_27219007_Chip-Seq_ERYTHROID_Human0.98075955
151RUNX1_27514584_Chip-Seq_MCF-7_Human0.97875578
152NANOG_19829295_ChIP-Seq_ESCs_Human0.97840876
153BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97739651
154NANOG_18555785_Chip-Seq_ESCs_Mouse0.96973872
155EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95864157
156E2F1_18555785_Chip-Seq_ESCs_Mouse0.94540703
157STAT1_17558387_ChIP-Seq_HELA_Human0.94274827
158AR_21572438_ChIP-Seq_LNCaP_Human0.93865108
159OCT1_27270436_Chip-Seq_PROSTATE_Human0.93543313
160ER_23166858_ChIP-Seq_MCF-7_Human0.92960759
161RING1B_27294783_Chip-Seq_ESCs_Mouse0.92650160
162OCT4_18555785_Chip-Seq_ESCs_Mouse0.91630633
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.91616283
164HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91200008
165VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91112391
166SOX2_18555785_Chip-Seq_ESCs_Mouse0.89995179
167CTCF_18555785_Chip-Seq_ESCs_Mouse0.89756845
168TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89613355
169SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89277175
170* EZH2_27294783_Chip-Seq_NPCs_Mouse0.88931390
171SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88752461
172ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88659684
173RING1B_27294783_Chip-Seq_NPCs_Mouse0.88389884
174ZFX_18555785_Chip-Seq_ESCs_Mouse0.88365668
175P53_22387025_ChIP-Seq_ESCs_Mouse0.88002297
176CSB_26484114_Chip-Seq_FIBROBLAST_Human0.87636603
177PIAS1_25552417_ChIP-Seq_VCAP_Human0.87400161
178SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87369869
179SOX2_20726797_ChIP-Seq_SW620_Human0.87345123
180MAF_26560356_Chip-Seq_TH1_Human0.86004667
181P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85947998
182PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85920879
183FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85727113
184RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85014247
185EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84403019
186GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83715009
187KLF4_18555785_Chip-Seq_ESCs_Mouse0.82420202

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color8.25067805
2MP0002254_reproductive_system_inflammat6.07457784
3MP0003878_abnormal_ear_physiology5.33848990
4MP0005377_hearing/vestibular/ear_phenot5.33848990
5MP0005670_abnormal_white_adipose5.13861657
6MP0005409_darkened_coat_color5.12743330
7MP0001188_hyperpigmentation4.77012415
8MP0009379_abnormal_foot_pigmentation4.49579265
9MP0001929_abnormal_gametogenesis3.95685821
10MP0004381_abnormal_hair_follicle3.93376890
11MP0005174_abnormal_tail_pigmentation3.61210886
12MP0000015_abnormal_ear_pigmentation3.06890521
13MP0004510_myositis2.89161699
14MP0001346_abnormal_lacrimal_gland2.88477308
15MP0001348_abnormal_lacrimal_gland2.86470718
16MP0002876_abnormal_thyroid_physiology2.84571370
17MP0002161_abnormal_fertility/fecundity2.57687831
18MP0000678_abnormal_parathyroid_gland2.55255793
19MP0000685_abnormal_immune_system2.46722586
20MP0001835_abnormal_antigen_presentation2.45584511
21MP0003718_maternal_effect2.11380687
22MP0005410_abnormal_fertilization2.08027316
23MP0003646_muscle_fatigue1.99514802
24MP0002132_abnormal_respiratory_system1.95520648
25MP0002277_abnormal_respiratory_mucosa1.94993688
26MP0003724_increased_susceptibility_to1.94791731
27MP0005645_abnormal_hypothalamus_physiol1.78079579
28MP0002210_abnormal_sex_determination1.75949873
29MP0001968_abnormal_touch/_nociception1.71208853
30MP0003453_abnormal_keratinocyte_physiol1.69411886
31MP0002822_catalepsy1.62740986
32MP0005379_endocrine/exocrine_gland_phen1.61822242
33MP0005310_abnormal_salivary_gland1.61107532
34MP0001853_heart_inflammation1.60822883
35MP0001485_abnormal_pinna_reflex1.59828752
36MP0002095_abnormal_skin_pigmentation1.59417920
37MP0003303_peritoneal_inflammation1.54933729
38MP0005423_abnormal_somatic_nervous1.53339264
39MP0000516_abnormal_urinary_system1.49726868
40MP0005367_renal/urinary_system_phenotyp1.49726868
41MP0005451_abnormal_body_composition1.49291019
42MP0002234_abnormal_pharynx_morphology1.45671404
43MP0001145_abnormal_male_reproductive1.45215599
44MP0006082_CNS_inflammation1.43882506
45MP0002177_abnormal_outer_ear1.40017456
46MP0009785_altered_susceptibility_to1.38093425
47MP0000653_abnormal_sex_gland1.37284634
48MP0005671_abnormal_response_to1.35376622
49MP0001486_abnormal_startle_reflex1.32994026
50MP0005025_abnormal_response_to1.32097745
51MP0001873_stomach_inflammation1.31907092
52MP0002148_abnormal_hypersensitivity_rea1.30031937
53MP0002138_abnormal_hepatobiliary_system1.27129714
54MP0009053_abnormal_anal_canal1.22392034
55MP0005387_immune_system_phenotype1.21977749
56MP0001790_abnormal_immune_system1.21977749
57MP0009764_decreased_sensitivity_to1.16399697
58MP0000534_abnormal_ureter_morphology1.15735976
59MP0001765_abnormal_ion_homeostasis1.12642320
60MP0005000_abnormal_immune_tolerance1.10302324
61MP0000613_abnormal_salivary_gland1.10023603
62MP0004859_abnormal_synaptic_plasticity1.08881358
63MP0005248_abnormal_Harderian_gland1.08521917
64MP0002127_abnormal_cardiovascular_syste1.06883128
65MP0004742_abnormal_vestibular_system1.06830062
66MP0000858_altered_metastatic_potential1.04786475
67MP0001963_abnormal_hearing_physiology1.04780524
68MP0003879_abnormal_hair_cell1.03837422
69MP0009115_abnormal_fat_cell1.01411583
70MP0003448_altered_tumor_morphology1.01320977
71MP0005666_abnormal_adipose_tissue0.98516403
72MP0000579_abnormal_nail_morphology0.97741244
73MP0003436_decreased_susceptibility_to0.97092180
74MP0001851_eye_inflammation0.95296631
75MP0005395_other_phenotype0.94921928
76MP0003880_abnormal_central_pattern0.91206480
77MP0000026_abnormal_inner_ear0.90029572
78MP0002166_altered_tumor_susceptibility0.89338352
79MP0003763_abnormal_thymus_physiology0.89218271
80MP0001800_abnormal_humoral_immune0.84396191
81MP0002229_neurodegeneration0.83612617
82MP0002638_abnormal_pupillary_reflex0.80312774
83MP0000955_abnormal_spinal_cord0.79674037
84MP0002723_abnormal_immune_serum0.79281640
85MP0009333_abnormal_splenocyte_physiolog0.79048300
86MP0002796_impaired_skin_barrier0.77563832
87MP0008569_lethality_at_weaning0.77273697
88MP0000681_abnormal_thyroid_gland0.76232249
89MP0002452_abnormal_antigen_presenting0.74111956
90MP0005375_adipose_tissue_phenotype0.73590469
91MP0002282_abnormal_trachea_morphology0.72391618
92MP0005257_abnormal_intraocular_pressure0.71596235
93MP0002067_abnormal_sensory_capabilities0.70755664
94MP0003279_aneurysm0.70423196
95MP0000383_abnormal_hair_follicle0.69493685
96MP0005551_abnormal_eye_electrophysiolog0.69266148
97MP0001819_abnormal_immune_cell0.68700429
98MP0002420_abnormal_adaptive_immunity0.67861217
99MP0001879_abnormal_lymphatic_vessel0.67675424
100MP0002735_abnormal_chemical_nociception0.67337071
101MP0004484_altered_response_of0.66824838
102MP0001905_abnormal_dopamine_level0.66624830
103MP0006292_abnormal_olfactory_placode0.65561607
104MP0002419_abnormal_innate_immunity0.65295136
105MP0001970_abnormal_pain_threshold0.65239478
106MP0005595_abnormal_vascular_smooth0.64766211
107MP0004782_abnormal_surfactant_physiolog0.64216153
108MP0004085_abnormal_heartbeat0.63036023
109MP0001958_emphysema0.62751032
110MP0003941_abnormal_skin_development0.62042681
111MP0003045_fibrosis0.61814726
112MP0002006_tumorigenesis0.61339239
113MP0001340_abnormal_eyelid_morphology0.61235483
114MP0008877_abnormal_DNA_methylation0.60606918
115MP0002557_abnormal_social/conspecific_i0.60560349
116MP0010155_abnormal_intestine_physiology0.60168723
117MP0005083_abnormal_biliary_tract0.59149632
118MP0009250_abnormal_appendicular_skeleto0.59127525
119MP0004883_abnormal_blood_vessel0.58909348
120MP0005253_abnormal_eye_physiology0.58445085
121MP0005636_abnormal_mineral_homeostasis0.58379918
122MP0005647_abnormal_sex_gland0.57778168
123MP0005464_abnormal_platelet_physiology0.57775552
124MP0005167_abnormal_blood-brain_barrier0.56609746
125MP0009697_abnormal_copulation0.56082313
126MP0002733_abnormal_thermal_nociception0.55986814
127MP0001666_abnormal_nutrient_absorption0.55779018
128MP0002405_respiratory_system_inflammati0.55678753
129MP0001216_abnormal_epidermal_layer0.54899535
130MP0003698_abnormal_male_reproductive0.54443769
131MP0001663_abnormal_digestive_system0.53722685
132MP0003638_abnormal_response/metabolism_0.52963813
133MP0005165_increased_susceptibility_to0.52958239
134MP0005164_abnormal_response_to0.52472138
135MP0001845_abnormal_inflammatory_respons0.52419416
136MP0003077_abnormal_cell_cycle0.52024862
137MP0004233_abnormal_muscle_weight0.49220799
138MP0000003_abnormal_adipose_tissue0.48907173
139* MP0000716_abnormal_immune_system0.48597119
140MP0009931_abnormal_skin_appearance0.47200082
141MP0000049_abnormal_middle_ear0.46704748
142MP0001270_distended_abdomen0.46673714
143MP0000566_synostosis0.46601794
144MP0002098_abnormal_vibrissa_morphology0.46576379
145MP0005535_abnormal_body_temperature0.45785443
146MP0003699_abnormal_female_reproductive0.44886833
147MP0000249_abnormal_blood_vessel0.44864587
148MP0000470_abnormal_stomach_morphology0.44847363
149MP0003137_abnormal_impulse_conducting0.43861963
150MP0010771_integument_phenotype0.43623840
151MP0002572_abnormal_emotion/affect_behav0.43498040
152MP0005166_decreased_susceptibility_to0.43478944
153MP0004036_abnormal_muscle_relaxation0.42334242
154MP0001533_abnormal_skeleton_physiology0.42155709
155MP0000371_diluted_coat_color0.42018409
156MP0001440_abnormal_grooming_behavior0.41983984
157MP0000343_altered_response_to0.41945767
158MP0002249_abnormal_larynx_morphology0.41607583
159MP0002009_preneoplasia0.41006078
160MP0003011_delayed_dark_adaptation0.40969826
161MP0002272_abnormal_nervous_system0.40689291
162MP0009745_abnormal_behavioral_response0.40523712
163MP0008469_abnormal_protein_level0.39911608
164MP0008995_early_reproductive_senescence0.39442291
165MP0008961_abnormal_basal_metabolism0.39108097
166MP0002653_abnormal_ependyma_morphology0.38044057
167MP0003936_abnormal_reproductive_system0.36607821
168MP0003091_abnormal_cell_migration0.36037709
169MP0003631_nervous_system_phenotype0.35763187
170MP0001501_abnormal_sleep_pattern0.34906479
171MP0005408_hypopigmentation0.34899255
172MP0002734_abnormal_mechanical_nocicepti0.32928937
173MP0010329_abnormal_lipoprotein_level0.31979694
174MP0005391_vision/eye_phenotype0.31537138
175MP0001984_abnormal_olfaction0.30789750
176MP0005623_abnormal_meninges_morphology0.29635979
177MP0000230_abnormal_systemic_arterial0.29428247

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.21676539
2Sex reversal (HP:0012245)5.69332469
3Abnormal sex determination (HP:0012244)5.69332469
4Asymmetric septal hypertrophy (HP:0001670)5.50638024
5Tubulointerstitial nephritis (HP:0001970)5.50331217
6Chronic mucocutaneous candidiasis (HP:0002728)5.42242466
7Recurrent cutaneous fungal infections (HP:0011370)5.42242466
8Abnormality of the axillary hair (HP:0100134)5.29051788
9Abnormality of secondary sexual hair (HP:0009888)5.29051788
10Chronic hepatic failure (HP:0100626)5.10328959
11Bony spicule pigmentary retinopathy (HP:0007737)5.00421110
12Eczematoid dermatitis (HP:0000976)4.81188097
13Hyperkalemia (HP:0002153)4.76909884
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.76383589
15Absent/shortened dynein arms (HP:0200106)4.70853539
16Dynein arm defect of respiratory motile cilia (HP:0012255)4.70853539
17Resting tremor (HP:0002322)4.68319241
18Abnormality of the nasal mucosa (HP:0000433)4.56025896
19Nasal polyposis (HP:0100582)4.38203747
20Male infertility (HP:0003251)4.32907760
21Obstructive sleep apnea (HP:0002870)4.30512002
22Bell-shaped thorax (HP:0001591)4.28616214
23Infertility (HP:0000789)4.23429606
24Abnormality of macular pigmentation (HP:0008002)4.17086905
25Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.13732583
26Cone-rod dystrophy (HP:0000548)4.01777920
27Facial shape deformation (HP:0011334)3.96796503
28Potter facies (HP:0002009)3.96796503
29Abnormal rod and cone electroretinograms (HP:0008323)3.88095898
30Hypoplasia of the thymus (HP:0000778)3.81642787
31Hypoplastic ischia (HP:0003175)3.66052624
32Aplasia/Hypoplasia of the earlobes (HP:0009906)3.57100905
33Aplasia/Hypoplasia of the spleen (HP:0010451)3.50718188
34Enlarged epiphyses (HP:0010580)3.47407397
35Impulsivity (HP:0100710)3.39311425
36Hypoalphalipoproteinemia (HP:0003233)3.34213519
37Abnormal spermatogenesis (HP:0008669)3.31302169
38Abnormality of the ischium (HP:0003174)3.27148647
39Amelogenesis imperfecta (HP:0000705)3.25777246
40Progressive sensorineural hearing impairment (HP:0000408)3.24405273
41Chronic otitis media (HP:0000389)3.20608957
42Azoospermia (HP:0000027)3.20420350
43Postural instability (HP:0002172)3.16536094
44Agammaglobulinemia (HP:0004432)3.16016759
45Recurrent skin infections (HP:0001581)3.12944189
46Abnormal respiratory motile cilium physiology (HP:0012261)3.10468789
47Abnormal respiratory epithelium morphology (HP:0012253)3.08046003
48Abnormal respiratory motile cilium morphology (HP:0005938)3.08046003
49Recurrent fungal infections (HP:0002841)3.07486497
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.98255232
51Keratoconjunctivitis (HP:0001096)2.94244220
52Chronic sinusitis (HP:0011109)2.94220234
53Asplenia (HP:0001746)2.92491124
54Attenuation of retinal blood vessels (HP:0007843)2.91690087
55Abnormal ciliary motility (HP:0012262)2.91592467
56Recurrent bronchitis (HP:0002837)2.90690490
57Menstrual irregularities (HP:0000858)2.88062190
58Truncal obesity (HP:0001956)2.85955102
59Unilateral renal agenesis (HP:0000122)2.84570359
60Abnormal hemoglobin (HP:0011902)2.84549186
61Renovascular hypertension (HP:0100817)2.84344632
62Bronchitis (HP:0012387)2.80869926
63Abnormality of the gastric mucosa (HP:0004295)2.80741051
64Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.77477818
65Abnormal urine output (HP:0012590)2.77218679
66Generalized aminoaciduria (HP:0002909)2.73910225
67Atrophic scars (HP:0001075)2.73856222
68Portal hypertension (HP:0001409)2.72674462
69Double outlet right ventricle (HP:0001719)2.70989907
70Congenital malformation of the right heart (HP:0011723)2.70989907
71Nephronophthisis (HP:0000090)2.69088381
72Chronic bronchitis (HP:0004469)2.66139080
73Prolonged neonatal jaundice (HP:0006579)2.65586163
74Insulin-resistant diabetes mellitus (HP:0000831)2.65132718
75Abnormality of potassium homeostasis (HP:0011042)2.64784135
76Right ventricular cardiomyopathy (HP:0011663)2.63330754
77Onycholysis (HP:0001806)2.63313726
78Progressive cerebellar ataxia (HP:0002073)2.63270133
79Fragile nails (HP:0001808)2.62980674
80Hyperactive renin-angiotensin system (HP:0000841)2.61553586
81Abnormality of the aortic arch (HP:0012303)2.61411833
82Optic disc pallor (HP:0000543)2.61043317
83Tubulointerstitial abnormality (HP:0001969)2.56979557
84Stage 5 chronic kidney disease (HP:0003774)2.54304232
85Renal dysplasia (HP:0000110)2.53436363
86Abnormality of the costochondral junction (HP:0000919)2.51839817
87Abnormality of the hepatic vasculature (HP:0006707)2.51199046
88Elevated erythrocyte sedimentation rate (HP:0003565)2.48166415
89Hypercortisolism (HP:0001578)2.47860751
90Stomatitis (HP:0010280)2.46708191
91Optic nerve hypoplasia (HP:0000609)2.40710782
92Abnormality of renal excretion (HP:0011036)2.39700012
93Split foot (HP:0001839)2.39176330
94Woolly hair (HP:0002224)2.38490918
95Ocular albinism (HP:0001107)2.35560290
96Polydipsia (HP:0001959)2.30966691
97Abnormal drinking behavior (HP:0030082)2.30966691
98Bronchiectasis (HP:0002110)2.29115760
99Abnormality of calcium-phosphate metabolism (HP:0100530)2.28208200
100Seborrheic dermatitis (HP:0001051)2.28035544
101Abnormality of the renal medulla (HP:0100957)2.27161099
102Thyroid-stimulating hormone excess (HP:0002925)2.23781469
103Interstitial pulmonary disease (HP:0006530)2.23249313
104Epiphyseal dysplasia (HP:0002656)2.22954889
105Aplasia/hypoplasia of the uterus (HP:0008684)2.21276074
106Flattened epiphyses (HP:0003071)2.21202655
107Nonprogressive disorder (HP:0003680)2.19894611
108Abnormality of the parathyroid morphology (HP:0011766)2.19649560
109Alacrima (HP:0000522)2.18800046
110Abnormal delayed hypersensitivity skin test (HP:0002963)2.18408788
111Myositis (HP:0100614)2.17540796
112Anhidrosis (HP:0000970)2.16626315
113Sleep apnea (HP:0010535)2.16298111
114Increased IgM level (HP:0003496)2.16293243
115Polyuria (HP:0000103)2.16222420
116Plantar hyperkeratosis (HP:0007556)2.16109166
117Laryngomalacia (HP:0001601)2.15450381
118Ventricular tachycardia (HP:0004756)2.15000639
119Meningitis (HP:0001287)2.13417644
120Increased IgE level (HP:0003212)2.12094895
121Milia (HP:0001056)2.10686651
122Recurrent pneumonia (HP:0006532)2.10434782
123Annular pancreas (HP:0001734)2.10307537
124Pruritus (HP:0000989)2.10226136
125Recurrent abscess formation (HP:0002722)2.10174646
126Abnormality of macrophages (HP:0004311)2.08789428
127Increased purine levels (HP:0004368)2.06254341
128Hyperuricemia (HP:0002149)2.06254341
129Hypophosphatemic rickets (HP:0004912)2.05455476
130Progressive hearing impairment (HP:0001730)2.04180941
131Widely patent fontanelles and sutures (HP:0004492)2.04088549
132Abnormal pupillary function (HP:0007686)2.03138392
133Gonadal dysgenesis (HP:0000133)2.02139272
134Rhinitis (HP:0012384)2.01665848
135Gastrointestinal stroma tumor (HP:0100723)2.01522118
136Hypergammaglobulinemia (HP:0010702)2.01206259
137Cellulitis (HP:0100658)2.00763245
138Osteomalacia (HP:0002749)1.98433289
139Hyponatremia (HP:0002902)1.96859837
140Germ cell neoplasia (HP:0100728)1.95981746
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.95003332
142Absent epiphyses (HP:0010577)1.95003332
143Recurrent bacterial skin infections (HP:0005406)1.94658890
144Myokymia (HP:0002411)1.94082582
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94070357
146Iris hypopigmentation (HP:0007730)1.93700669
147Abnormality of the epiphysis of the femoral head (HP:0010574)1.93557265
148Type 2 muscle fiber atrophy (HP:0003554)1.92822066
149Emphysema (HP:0002097)1.92069607
150Nasolacrimal duct obstruction (HP:0000579)1.90308031
151Obstructive lung disease (HP:0006536)1.88423509
152Chronic obstructive pulmonary disease (HP:0006510)1.88423509
153Decreased circulating renin level (HP:0003351)1.88044455
154Tetany (HP:0001281)1.87436710
155Subcapsular cataract (HP:0000523)1.85530121
156Recurrent sinusitis (HP:0011108)1.82620300
157Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.82045057
158Abnormality of femoral epiphyses (HP:0006499)1.82045057
159Abnormality of the pubic bones (HP:0003172)1.81437571
160Muscle fiber atrophy (HP:0100295)1.80684090
161Lip pit (HP:0100267)1.80350270
162Abnormal ventriculo-arterial connection (HP:0011563)1.78798172
163Transposition of the great arteries (HP:0001669)1.78798172
164Abnormal connection of the cardiac segments (HP:0011545)1.78798172
165Septo-optic dysplasia (HP:0100842)1.78614815
166Adrenal overactivity (HP:0002717)1.78402578
167Ulnar claw (HP:0001178)1.78324415
168Mediastinal lymphadenopathy (HP:0100721)1.77780692
169Abnormality of chloride homeostasis (HP:0011422)1.77561706
170Renal Fanconi syndrome (HP:0001994)1.77381908
171Pulmonary artery stenosis (HP:0004415)1.76575581
172Type I diabetes mellitus (HP:0100651)1.76230199
173Bradycardia (HP:0001662)1.75948865
174Bile duct proliferation (HP:0001408)1.75731835
175Abnormal biliary tract physiology (HP:0012439)1.75731835
176Colitis (HP:0002583)1.75125178
177Intellectual disability, moderate (HP:0002342)1.75075045
178Abnormality of dental color (HP:0011073)1.74922134
179Hemoptysis (HP:0002105)1.74597448
180Flat capital femoral epiphysis (HP:0003370)1.74588610
181Recurrent corneal erosions (HP:0000495)1.73977694
182Protuberant abdomen (HP:0001538)1.73452177
183Hypoparathyroidism (HP:0000829)1.72438758
184Fatigable weakness (HP:0003473)1.72316035

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.36491007
2CASK6.55312255
3PHKG25.96475437
4PHKG15.96475437
5DDR24.84646553
6CLK14.46924751
7INSRR3.31385282
8BRD43.09828108
9PNCK3.05263619
10MAP4K23.03245896
11PLK23.00047175
12STK38L2.60347410
13MAP3K142.50555370
14PRKD32.50192236
15CAMK1G2.47113329
16IKBKE2.43983684
17MAPK152.22220641
18TLK12.11456287
19TBK11.99358736
20MST1R1.94831842
21EPHA31.90129870
22NME21.72148057
23EPHB11.71509569
24PDPK11.69366276
25CDK121.68345750
26NLK1.65166994
27PRKD21.63199846
28PDK11.56042589
29MST41.54894436
30EPHA21.48161165
31NME11.46332824
32BLK1.45555861
33WNK11.40743208
34NEK61.37646729
35STK381.35157247
36FGR1.34013658
37IRAK31.33722754
38MAP3K11.28853987
39CDK71.27329359
40MKNK21.26857087
41FES1.22592855
42IRAK11.19611158
43IRAK41.18960248
44FER1.17385154
45FGFR41.09234920
46MUSK1.05110278
47KSR21.00997955
48CSK0.98968010
49KIT0.97551308
50GRK50.97507996
51EPHB20.97420027
52IKBKB0.96914757
53MAP3K90.95702125
54PKN10.94756884
55HIPK20.94189313
56CAMK1D0.93490729
57TGFBR20.85765945
58SIK20.85345989
59AKT30.85127800
60TYK20.84799979
61TYRO30.84158201
62MAP3K110.83781244
63EIF2AK20.82833186
64UHMK10.81549213
65DYRK1B0.81307571
66RIPK40.80637518
67TNIK0.78619426
68DAPK30.76628199
69GRK10.76211487
70JAK10.75184942
71PAK20.73553226
72BRAF0.73350835
73YES10.72867758
74LATS20.71693323
75RPS6KA20.71359630
76BMPR20.71079063
77MAP3K20.70918235
78DYRK30.68206848
79TEC0.65907091
80RPS6KA10.65008976
81MKNK10.64184224
82DAPK20.63238209
83TESK10.61936439
84MAP2K20.60139397
85PAK10.60039962
86PRPF4B0.58925118
87STK390.58591781
88PRKAA20.58344441
89MAP3K80.57689121
90WNK40.57424077
91JAK30.56931600
92JAK20.56614366
93SGK4940.56383007
94SGK2230.56383007
95CDK30.56255741
96CAMK2B0.55574683
97MATK0.50773995
98ROCK10.49363398
99RPS6KA50.47335174
100PRKG10.47318557
101BMPR1B0.47083247
102TXK0.46681215
103BTK0.46421792
104GSK3B0.45684028
105TIE10.45291461
106HCK0.44432592
107CDK20.44041259
108FGFR30.43839817
109LATS10.43800092
110ERN10.43741983
111PTK2B0.43315366
112VRK10.43311939
113SRPK10.43066989
114MTOR0.41806868
115CAMK2G0.41583357
116MAPK10.40910981
117PRKG20.40484134
118PRKCD0.40302615
119RPS6KC10.39465036
120RPS6KL10.39465036
121CDK10.39328224
122MAPKAPK50.39229311
123CHUK0.38881544
124PRKD10.38820710
125MAPK80.37369614
126CDK40.36647477
127CAMK40.36323309
128TESK20.36039005
129RPS6KA60.35639847
130STK110.34997217
131LCK0.33916382
132ARAF0.33824112
133ILK0.33806975
134MAP3K70.33310011
135BMX0.33033925
136PIK3CG0.31989201
137RPS6KB20.31531873
138GRK70.31039632
139CAMK2A0.29821094
140SGK10.29443958
141CAMK10.28782877
142MAP2K70.28247237
143PRKCZ0.27232782
144SYK0.27227622
145PIM20.26511564
146PRKCG0.26169968
147CHEK10.25510755
148PRKCB0.25368922
149LYN0.25180309
150ROCK20.25074805
151DYRK20.25053428
152ICK0.24987740
153GRK60.23827133
154MET0.22629445
155MAPK140.22329887
156NEK20.22054561
157MAPK100.20825802
158PIM10.19694844
159MAPK110.19016285
160ITK0.17781906
161MARK10.17483190
162MARK20.16914260
163NTRK30.16564342
164SGK20.16507418
165MINK10.15338536
166AKT10.14624238
167ACVR1B0.13723061
168BRSK10.11877538
169OXSR10.11743499
170MAP3K40.10690328
171RIPK10.08648109
172PINK10.08271486
173PRKAA10.07525298

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.29474414
2Fatty acid biosynthesis_Homo sapiens_hsa000617.12626036
3Ribosome_Homo sapiens_hsa030103.23219185
4Other glycan degradation_Homo sapiens_hsa005113.09665040
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.82007103
6Primary immunodeficiency_Homo sapiens_hsa053402.73171957
7Antigen processing and presentation_Homo sapiens_hsa046122.64293231
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.58876745
9Phototransduction_Homo sapiens_hsa047442.43414683
10Butanoate metabolism_Homo sapiens_hsa006502.37123211
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.19579140
12Glycerophospholipid metabolism_Homo sapiens_hsa005642.09015477
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.08131648
14Fatty acid degradation_Homo sapiens_hsa000711.93490803
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92772170
16Ether lipid metabolism_Homo sapiens_hsa005651.83915015
17Histidine metabolism_Homo sapiens_hsa003401.83846634
18Asthma_Homo sapiens_hsa053101.82626461
19Leishmaniasis_Homo sapiens_hsa051401.75277785
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.70144695
21Fatty acid metabolism_Homo sapiens_hsa012121.70058387
22Measles_Homo sapiens_hsa051621.63148775
23Type II diabetes mellitus_Homo sapiens_hsa049301.60337759
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.57839788
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.56673378
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.55798989
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.47819598
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.46237097
29Arachidonic acid metabolism_Homo sapiens_hsa005901.45693170
30Phenylalanine metabolism_Homo sapiens_hsa003601.44590387
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.42866732
32Type I diabetes mellitus_Homo sapiens_hsa049401.42745503
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41286105
34Graft-versus-host disease_Homo sapiens_hsa053321.39425897
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35650823
36Osteoclast differentiation_Homo sapiens_hsa043801.34794096
37RNA transport_Homo sapiens_hsa030131.34063299
38Rheumatoid arthritis_Homo sapiens_hsa053231.32314698
39Allograft rejection_Homo sapiens_hsa053301.29254556
40PPAR signaling pathway_Homo sapiens_hsa033201.22373035
41Sulfur relay system_Homo sapiens_hsa041221.19205258
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17935793
43Melanogenesis_Homo sapiens_hsa049161.15511610
44Sphingolipid metabolism_Homo sapiens_hsa006001.14916291
45Toll-like receptor signaling pathway_Homo sapiens_hsa046201.13175191
46Chemokine signaling pathway_Homo sapiens_hsa040621.10969124
47Endocytosis_Homo sapiens_hsa041441.09298124
48Linoleic acid metabolism_Homo sapiens_hsa005911.08492518
49Malaria_Homo sapiens_hsa051441.08210296
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06456948
51Autoimmune thyroid disease_Homo sapiens_hsa053201.04564688
52African trypanosomiasis_Homo sapiens_hsa051431.03608602
53Long-term depression_Homo sapiens_hsa047301.01890592
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01589625
55Nicotine addiction_Homo sapiens_hsa050331.01040258
56Toxoplasmosis_Homo sapiens_hsa051450.98371698
57Protein digestion and absorption_Homo sapiens_hsa049740.97292849
58Arginine and proline metabolism_Homo sapiens_hsa003300.96569062
59Calcium signaling pathway_Homo sapiens_hsa040200.95058688
60Viral myocarditis_Homo sapiens_hsa054160.94889840
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.94534296
62Inositol phosphate metabolism_Homo sapiens_hsa005620.94501841
63TNF signaling pathway_Homo sapiens_hsa046680.94345002
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.94302609
65Herpes simplex infection_Homo sapiens_hsa051680.93346813
66Acute myeloid leukemia_Homo sapiens_hsa052210.91592472
67Pertussis_Homo sapiens_hsa051330.91453421
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90865853
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90182177
70B cell receptor signaling pathway_Homo sapiens_hsa046620.88826029
71Synaptic vesicle cycle_Homo sapiens_hsa047210.86468960
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86054973
73Basal cell carcinoma_Homo sapiens_hsa052170.84556832
74Taste transduction_Homo sapiens_hsa047420.84405581
75Influenza A_Homo sapiens_hsa051640.84185793
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.83596048
77Salivary secretion_Homo sapiens_hsa049700.82609239
78Circadian entrainment_Homo sapiens_hsa047130.82300999
79Hepatitis B_Homo sapiens_hsa051610.82039001
80Hepatitis C_Homo sapiens_hsa051600.80618289
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79204055
82T cell receptor signaling pathway_Homo sapiens_hsa046600.78905592
83Estrogen signaling pathway_Homo sapiens_hsa049150.78794290
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78012920
85Arginine biosynthesis_Homo sapiens_hsa002200.77934745
86Selenocompound metabolism_Homo sapiens_hsa004500.76646177
87Oocyte meiosis_Homo sapiens_hsa041140.75596832
88ABC transporters_Homo sapiens_hsa020100.74745991
89Renin-angiotensin system_Homo sapiens_hsa046140.74352080
90Axon guidance_Homo sapiens_hsa043600.73303798
91Tuberculosis_Homo sapiens_hsa051520.72842195
92Oxidative phosphorylation_Homo sapiens_hsa001900.72735448
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72607913
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72590274
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70636610
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70345560
97Hedgehog signaling pathway_Homo sapiens_hsa043400.69581510
98Glycerolipid metabolism_Homo sapiens_hsa005610.67639141
99Hematopoietic cell lineage_Homo sapiens_hsa046400.67073541
100Salmonella infection_Homo sapiens_hsa051320.66335785
101ECM-receptor interaction_Homo sapiens_hsa045120.64362094
102MAPK signaling pathway_Homo sapiens_hsa040100.64258504
103Staphylococcus aureus infection_Homo sapiens_hsa051500.63691542
104Apoptosis_Homo sapiens_hsa042100.63444507
105Tyrosine metabolism_Homo sapiens_hsa003500.62900818
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62375594
107Ras signaling pathway_Homo sapiens_hsa040140.61677767
108Thyroid cancer_Homo sapiens_hsa052160.60941508
109Gastric acid secretion_Homo sapiens_hsa049710.60886182
110Wnt signaling pathway_Homo sapiens_hsa043100.59180817
111Fat digestion and absorption_Homo sapiens_hsa049750.58008732
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57625028
113Cardiac muscle contraction_Homo sapiens_hsa042600.56643052
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56033245
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55384269
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53738658
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53503835
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.53101605
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52904064
120Amoebiasis_Homo sapiens_hsa051460.52610052
121Olfactory transduction_Homo sapiens_hsa047400.52552957
122Dorso-ventral axis formation_Homo sapiens_hsa043200.52166232
123GnRH signaling pathway_Homo sapiens_hsa049120.50733077
124Glutamatergic synapse_Homo sapiens_hsa047240.50567539
125Huntingtons disease_Homo sapiens_hsa050160.50333151
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50128195
127Alzheimers disease_Homo sapiens_hsa050100.49916496
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48883109
129Serotonergic synapse_Homo sapiens_hsa047260.47647669
130Glucagon signaling pathway_Homo sapiens_hsa049220.47461358
131Tight junction_Homo sapiens_hsa045300.46909573
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46402185
133Pathways in cancer_Homo sapiens_hsa052000.45230681
134Morphine addiction_Homo sapiens_hsa050320.45161950
135Amphetamine addiction_Homo sapiens_hsa050310.44796328
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.44775073
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44567210
138Phagosome_Homo sapiens_hsa041450.44268513
139Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44004417
140Maturity onset diabetes of the young_Homo sapiens_hsa049500.42594641
141Protein export_Homo sapiens_hsa030600.42247079
142Renin secretion_Homo sapiens_hsa049240.41602349
143Cholinergic synapse_Homo sapiens_hsa047250.38551475
144Melanoma_Homo sapiens_hsa052180.38484608
145Small cell lung cancer_Homo sapiens_hsa052220.38252095
146Oxytocin signaling pathway_Homo sapiens_hsa049210.38057612
147Purine metabolism_Homo sapiens_hsa002300.37954599
148Retinol metabolism_Homo sapiens_hsa008300.37792562
149Prostate cancer_Homo sapiens_hsa052150.36567169
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36448890
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36368104
152cAMP signaling pathway_Homo sapiens_hsa040240.35467798
153Bile secretion_Homo sapiens_hsa049760.35398176
154VEGF signaling pathway_Homo sapiens_hsa043700.35060684
155Long-term potentiation_Homo sapiens_hsa047200.35057541
156Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34806959
157Pancreatic secretion_Homo sapiens_hsa049720.34279149
158Viral carcinogenesis_Homo sapiens_hsa052030.32630016
159Insulin secretion_Homo sapiens_hsa049110.32560772
160Basal transcription factors_Homo sapiens_hsa030220.28252600
161Alcoholism_Homo sapiens_hsa050340.25969893
162Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25368493
163GABAergic synapse_Homo sapiens_hsa047270.24799128
164Prolactin signaling pathway_Homo sapiens_hsa049170.23611698
165Biosynthesis of amino acids_Homo sapiens_hsa012300.20897335
166Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.20460951
167Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19564103
168Legionellosis_Homo sapiens_hsa051340.18511224
169Adherens junction_Homo sapiens_hsa045200.17185402
170mRNA surveillance pathway_Homo sapiens_hsa030150.15622993

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