TBC1D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2 (USP6; MIM 604334), yeast Bub2, and CDC16 (MIM 603461) (White et al., 2000 [PubMed 10965142]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)4.72561668
2B cell receptor signaling pathway (GO:0050853)4.69810428
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.51130385
4positive regulation by organism of defense response of other organism involved in symbiotic interact4.51130385
5modulation by symbiont of host immune response (GO:0052553)4.51130385
6positive regulation by symbiont of host defense response (GO:0052509)4.51130385
7modulation by symbiont of host defense response (GO:0052031)4.51130385
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.51130385
9macrophage activation involved in immune response (GO:0002281)4.08811841
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.01517063
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.01517063
12nuclear pore complex assembly (GO:0051292)4.00251246
13cellular extravasation (GO:0045123)4.00215292
14antigen processing and presentation of endogenous antigen (GO:0019883)3.96935796
15NIK/NF-kappaB signaling (GO:0038061)3.96361000
16response to peptidoglycan (GO:0032494)3.87035469
17positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.76551672
18positive regulation of gamma-delta T cell activation (GO:0046645)3.72080840
19nuclear pore organization (GO:0006999)3.59981541
20germinal center formation (GO:0002467)3.54643394
21detection of molecule of bacterial origin (GO:0032490)3.52315488
22detection of other organism (GO:0098543)3.49224242
23pinocytosis (GO:0006907)3.47738124
24regulation of interferon-beta biosynthetic process (GO:0045357)3.37772140
25positive regulation of B cell differentiation (GO:0045579)3.34505952
26COPI coating of Golgi vesicle (GO:0048205)3.33483757
27Golgi transport vesicle coating (GO:0048200)3.33483757
28negative regulation of interleukin-12 production (GO:0032695)3.30883615
29negative regulation of erythrocyte differentiation (GO:0045647)3.24323103
30regulation of interleukin-12 biosynthetic process (GO:0045075)3.23413521
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.20105744
32detection of external biotic stimulus (GO:0098581)3.17668398
33detection of bacterium (GO:0016045)3.13367980
34histone H3-K36 demethylation (GO:0070544)3.11152276
35natural killer cell mediated immunity (GO:0002228)3.09427053
36natural killer cell mediated cytotoxicity (GO:0042267)3.09427053
37pore complex assembly (GO:0046931)3.08816303
38myeloid cell activation involved in immune response (GO:0002275)3.07125342
39positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.05490820
40production of molecular mediator involved in inflammatory response (GO:0002532)3.04322038
41interkinetic nuclear migration (GO:0022027)3.03110266
42antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01071756
43positive regulation of natural killer cell differentiation (GO:0032825)3.00194605
44regulation of gamma-delta T cell differentiation (GO:0045586)2.99820849
45regulation of B cell differentiation (GO:0045577)2.98026942
46macrophage activation (GO:0042116)2.96873381
47regulation of mast cell degranulation (GO:0043304)2.95956310
48regulation of leukocyte degranulation (GO:0043300)2.94851631
49positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.94247043
50regulation of myeloid leukocyte mediated immunity (GO:0002886)2.94156909
51regulation of mast cell activation involved in immune response (GO:0033006)2.90271075
52response to host immune response (GO:0052572)2.88736009
53response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.88736009
54NLS-bearing protein import into nucleus (GO:0006607)2.87715128
55regulation of gamma-delta T cell activation (GO:0046643)2.86864107
56positive thymic T cell selection (GO:0045059)2.80777045
57B cell proliferation (GO:0042100)2.79415966
58detection of biotic stimulus (GO:0009595)2.79010278
59positive regulation of histone deacetylation (GO:0031065)2.78347382
60heterochromatin organization (GO:0070828)2.76872515
61defense response to protozoan (GO:0042832)2.76254277
62regulation of T-helper 2 cell differentiation (GO:0045628)2.75013101
63regulation of platelet aggregation (GO:0090330)2.74376319
64microglial cell activation (GO:0001774)2.74270718
65antigen processing and presentation via MHC class Ib (GO:0002475)2.74150031
66response to host (GO:0075136)2.73116880
67response to host defenses (GO:0052200)2.73116880
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.73116880
69positive regulation of mast cell activation (GO:0033005)2.71226040
70morphogenesis of an endothelium (GO:0003159)2.68437016
71endothelial tube morphogenesis (GO:0061154)2.68437016
72growth hormone receptor signaling pathway (GO:0060396)2.67020950
73regulation of antigen processing and presentation (GO:0002577)2.66584217
74response to protozoan (GO:0001562)2.64868785
75neutrophil activation (GO:0042119)2.62478787
76mitotic chromosome condensation (GO:0007076)2.61986370
77cytoplasmic mRNA processing body assembly (GO:0033962)2.61300267
78B cell homeostasis (GO:0001782)2.60164477
79cellular response to vitamin D (GO:0071305)2.57854919
80JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.56561054
81chromatin assembly (GO:0031497)2.54937757
82monoubiquitinated protein deubiquitination (GO:0035520)2.54368679
83mature B cell differentiation (GO:0002335)2.53473278
84gene silencing by RNA (GO:0031047)2.53036054
85mature B cell differentiation involved in immune response (GO:0002313)2.52535272
86positive regulation of mast cell degranulation (GO:0043306)2.52529090
87positive regulation of mast cell activation involved in immune response (GO:0033008)2.52529090
88mitotic sister chromatid cohesion (GO:0007064)2.52255873
89regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.51972196
90positive regulation of interferon-alpha production (GO:0032727)2.51836586
91positive regulation of Cdc42 GTPase activity (GO:0043089)2.50824455
92granulocyte activation (GO:0036230)2.50090586
93regulation of mast cell activation (GO:0033003)2.49582026
94mitotic nuclear envelope disassembly (GO:0007077)2.49178241
95lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48632136
96B cell mediated immunity (GO:0019724)2.48470750
97negative regulation of cell killing (GO:0031342)2.48136012
98negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.48136012
99negative regulation of type 2 immune response (GO:0002829)2.47758905
100natural killer cell differentiation (GO:0001779)2.46834031
101protein localization to chromosome, centromeric region (GO:0071459)2.46460920
102positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.46099317
103positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.46099317
104positive regulation of mitotic sister chromatid separation (GO:1901970)2.46099317
105cellular response to thyroid hormone stimulus (GO:0097067)2.45931677
106cellular hyperosmotic response (GO:0071474)2.45703725
107mRNA stabilization (GO:0048255)2.45000105
108RNA stabilization (GO:0043489)2.45000105
109phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.44893529
110stress fiber assembly (GO:0043149)2.44766626
111negative regulation of myotube differentiation (GO:0010832)2.44571370
112neutrophil mediated immunity (GO:0002446)2.44480889
113response to muramyl dipeptide (GO:0032495)2.44251339
114dosage compensation (GO:0007549)2.44171323
115respiratory burst (GO:0045730)2.43193887
116positive regulation of Rap GTPase activity (GO:0032854)2.43129616
117mannose metabolic process (GO:0006013)2.42563367
118negative thymic T cell selection (GO:0045060)2.41982828
119protein localization to kinetochore (GO:0034501)2.41696794
120negative regulation of T cell mediated immunity (GO:0002710)2.41584128
121regulation of histone H3-K9 methylation (GO:0051570)2.40268423
122nuclear envelope disassembly (GO:0051081)2.39372845
123membrane disassembly (GO:0030397)2.39372845
124regulation of interferon-alpha production (GO:0032647)2.39245545
125T cell migration (GO:0072678)2.38765673
126piRNA metabolic process (GO:0034587)2.38693573
127negative regulation of lymphocyte mediated immunity (GO:0002707)2.38692226
128negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.38514743
129negative regulation of histone methylation (GO:0031061)2.38265676
130response to type I interferon (GO:0034340)2.37922522
131I-kappaB phosphorylation (GO:0007252)2.37598876
132negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.37414524
133negative regulation of T-helper cell differentiation (GO:0045623)2.37414524
134pre-miRNA processing (GO:0031054)2.36897734
135regulation of type I interferon-mediated signaling pathway (GO:0060338)2.36681280
136regulation of RIG-I signaling pathway (GO:0039535)2.33716341
137thymic T cell selection (GO:0045061)2.33515843
138regulation of sister chromatid cohesion (GO:0007063)2.33214959
139regulation of necroptotic process (GO:0060544)2.31401696
140cellular response to type I interferon (GO:0071357)2.30942623
141type I interferon signaling pathway (GO:0060337)2.30942623
142negative T cell selection (GO:0043383)2.29435656
143regulation of T-helper 1 cell differentiation (GO:0045625)2.28551111
144synaptonemal complex assembly (GO:0007130)2.27374848
145peptidyl-lysine dimethylation (GO:0018027)2.24949259
146cell adhesion mediated by integrin (GO:0033627)2.24465551
147regulation of protein polyubiquitination (GO:1902914)2.24191874
148T cell selection (GO:0045058)2.23422310
149striated muscle atrophy (GO:0014891)2.21806593
150regulation of dendritic cell antigen processing and presentation (GO:0002604)2.21524172
151cellular response to growth hormone stimulus (GO:0071378)2.20332640
152immunoglobulin mediated immune response (GO:0016064)2.20079500
153cellular response to interferon-alpha (GO:0035457)2.19939888
154interferon-gamma secretion (GO:0072643)2.19910759
155positive regulation of protein deacetylation (GO:0090312)2.19766467
156corticosteroid receptor signaling pathway (GO:0031958)2.16348410
157hepatocyte apoptotic process (GO:0097284)2.16159357
158activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.15216568
159positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.15209516
160regulation of alpha-beta T cell proliferation (GO:0046640)2.14594232
161myeloid dendritic cell differentiation (GO:0043011)2.12928648
162positive regulation of nuclease activity (GO:0032075)2.12213075
163positive regulation of p38MAPK cascade (GO:1900745)2.11678978
164gene silencing (GO:0016458)2.11572763
165regulation of response to interferon-gamma (GO:0060330)2.09461211
166regulation of integrin activation (GO:0033623)2.07228982
167vascular endothelial growth factor signaling pathway (GO:0038084)2.07126601
168regulation of T cell tolerance induction (GO:0002664)2.06963760
169positive regulation of interferon-beta production (GO:0032728)2.06483306
170regulation of RNA export from nucleus (GO:0046831)2.06433671
171interferon-gamma-mediated signaling pathway (GO:0060333)2.05681167
172synaptonemal complex organization (GO:0070193)2.05355455
173positive regulation of SMAD protein import into nucleus (GO:0060391)2.04741756
174positive regulation of protein import into nucleus, translocation (GO:0033160)2.04735120
175neutrophil activation involved in immune response (GO:0002283)2.04687919
176regulation of nuclease activity (GO:0032069)2.03378716
177positive regulation of interleukin-12 production (GO:0032735)2.02904464
178chromosome condensation (GO:0030261)2.02299324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.42145037
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.34956256
3* IRF8_22096565_ChIP-ChIP_GC-B_Human3.77163172
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.71304494
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.59788043
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.37626136
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.13908365
8MYC_22102868_ChIP-Seq_BL_Human2.80676917
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.77983222
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.77648484
11SCL_19346495_ChIP-Seq_HPC-7_Human2.74754758
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.51889429
13* IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.51224730
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42706952
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.39611815
16VDR_24787735_ChIP-Seq_THP-1_Human2.27920325
17* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.27889706
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18470134
19ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.11322359
20* TCF7_22412390_ChIP-Seq_EML_Mouse2.04423621
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.03016348
22* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97790447
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95940107
24MAF_26560356_Chip-Seq_TH1_Human1.94183843
25* MYB_26560356_Chip-Seq_TH2_Human1.89629111
26VDR_21846776_ChIP-Seq_THP-1_Human1.86605999
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.85071604
28MYB_26560356_Chip-Seq_TH1_Human1.82286323
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81912262
30* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.78447133
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78300043
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.76127819
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75782212
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74967439
35UTX_26944678_Chip-Seq_JUKART_Human1.73195328
36* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72853261
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70796992
38E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68564705
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.68216864
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62603555
41* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.57143725
42KDM2B_26808549_Chip-Seq_DND41_Human1.56524554
43* GATA1_19941827_ChIP-Seq_MEL_Mouse1.56165751
44FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53258719
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48222490
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47960905
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.47574669
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45924493
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.45351401
50* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44296422
51* SPI1_23547873_ChIP-Seq_NB4_Human1.40221215
52VDR_24763502_ChIP-Seq_THP-1_Human1.39909414
53GATA1_22025678_ChIP-Seq_K562_Human1.38370676
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.38308855
55GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34018100
56GATA3_27048872_Chip-Seq_THYMUS_Human1.33102894
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32515388
58AR_21909140_ChIP-Seq_LNCAP_Human1.31085464
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30154463
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29982024
61* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29532308
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28597052
63TFEB_21752829_ChIP-Seq_HELA_Human1.27630699
64KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23739048
65SPI1_23127762_ChIP-Seq_K562_Human1.22812009
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20628111
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.18747661
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.18747661
69RUNX_20019798_ChIP-Seq_JUKART_Human1.17413133
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17265282
71GATA1_19941827_ChIP-Seq_MEL86_Mouse1.16434790
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16022676
73PU_27001747_Chip-Seq_BMDM_Mouse1.13829869
74* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12248748
75* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.12062444
76CLOCK_20551151_ChIP-Seq_293T_Human1.11931590
77NCOR1_26117541_ChIP-Seq_K562_Human1.11261225
78ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07570798
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07525869
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06935526
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05819354
82MAF_26560356_Chip-Seq_TH2_Human1.05766857
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05564727
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04567153
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03505022
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03238079
87* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02691030
88* BRD4_25478319_ChIP-Seq_HGPS_Human1.02629233
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02098024
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01978932
91HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01898891
92* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01127144
93UBF1/2_26484160_Chip-Seq_HMECs_Human1.00828622
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00647974
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00121893
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00121893
97FOXO3_23340844_ChIP-Seq_DLD1_Human0.99925200
98P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99281153
99ATF3_27146783_Chip-Seq_COLON_Human0.99260712
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98961628
101STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98925214
102GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98413700
103* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97634999
104SMRT_27268052_Chip-Seq_Bcells_Human0.97573000
105* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96825030
106GATA6_25053715_ChIP-Seq_YYC3_Human0.96655928
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96175004
108CIITA_25753668_ChIP-Seq_RAJI_Human0.96088947
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95919711
110NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95025175
111STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93717566
112* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93602417
113* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92109880
114* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92018178
115DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91915533
116BP1_19119308_ChIP-ChIP_Hs578T_Human0.90836774
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90501890
118STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90356371
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90236229
120GATA2_19941826_ChIP-Seq_K562_Human0.90203303
121CHD1_26751641_Chip-Seq_LNCaP_Human0.89714333
122* FOXA2_19822575_ChIP-Seq_HepG2_Human0.88966627
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88718154
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88308466
125KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87479116
126GATA3_26560356_Chip-Seq_TH2_Human0.86762814
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.86573000
128SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86271684
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85135247
130TP63_19390658_ChIP-ChIP_HaCaT_Human0.85058170
131* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84969699
132* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84032115
133EP300_21415370_ChIP-Seq_HL-1_Mouse0.83892055
134GATA1_19941826_ChIP-Seq_K562_Human0.83733333
135CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80418702
136KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78831637
137KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78831637
138KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78831637
139* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77551960
140* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76342218
141LXR_22158963_ChIP-Seq_LIVER_Mouse0.76078604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog2.82883726
2MP0010352_gastrointestinal_tract_polyps2.75738065
3MP0005451_abnormal_body_composition2.52659581
4MP0003300_gastrointestinal_ulcer2.50387737
5MP0003724_increased_susceptibility_to2.47545924
6MP0000569_abnormal_digit_pigmentation2.46245067
7MP0000685_abnormal_immune_system2.40156541
8MP0005076_abnormal_cell_differentiation2.38046050
9MP0001835_abnormal_antigen_presentation2.17182039
10MP0010307_abnormal_tumor_latency2.12444836
11MP0002166_altered_tumor_susceptibility2.09648804
12MP0003705_abnormal_hypodermis_morpholog2.07694951
13MP0009278_abnormal_bone_marrow2.07141114
14MP0003303_peritoneal_inflammation2.01097707
15MP0003828_pulmonary_edema1.99445121
16MP0003566_abnormal_cell_adhesion1.94473790
17MP0003646_muscle_fatigue1.93257876
18MP0005387_immune_system_phenotype1.92223197
19MP0001790_abnormal_immune_system1.92223197
20MP0005464_abnormal_platelet_physiology1.89692622
21MP0006054_spinal_hemorrhage1.82080729
22MP0004808_abnormal_hematopoietic_stem1.79727189
23MP0003172_abnormal_lysosome_physiology1.77848614
24MP0003436_decreased_susceptibility_to1.77389686
25MP0004510_myositis1.75539014
26MP0002138_abnormal_hepatobiliary_system1.70006818
27MP0001800_abnormal_humoral_immune1.68583119
28MP0002006_tumorigenesis1.67822009
29MP0008438_abnormal_cutaneous_collagen1.63336815
30MP0004036_abnormal_muscle_relaxation1.61027080
31MP0003191_abnormal_cellular_cholesterol1.57733270
32MP0002452_abnormal_antigen_presenting1.56374820
33MP0002254_reproductive_system_inflammat1.52676325
34MP0004084_abnormal_cardiac_muscle1.50029777
35MP0005000_abnormal_immune_tolerance1.48997569
36MP0000733_abnormal_muscle_development1.47332818
37MP0003763_abnormal_thymus_physiology1.46435103
38MP0003091_abnormal_cell_migration1.42446162
39MP0008877_abnormal_DNA_methylation1.38778686
40MP0002398_abnormal_bone_marrow1.38567560
41MP0002723_abnormal_immune_serum1.38525462
42MP0008057_abnormal_DNA_replication1.38051066
43MP0008260_abnormal_autophagy1.36151533
44MP0000465_gastrointestinal_hemorrhage1.35686464
45MP0001819_abnormal_immune_cell1.35503528
46MP0003077_abnormal_cell_cycle1.35147500
47MP0004130_abnormal_muscle_cell1.34903982
48MP0005666_abnormal_adipose_tissue1.34692982
49MP0002420_abnormal_adaptive_immunity1.34283588
50MP0010234_abnormal_vibrissa_follicle1.30438031
51MP0003950_abnormal_plasma_membrane1.29597935
52MP0004947_skin_inflammation1.26603574
53MP0003448_altered_tumor_morphology1.25309324
54MP0008007_abnormal_cellular_replicative1.25200740
55MP0002396_abnormal_hematopoietic_system1.24010666
56MP0005671_abnormal_response_to1.23656960
57MP0004185_abnormal_adipocyte_glucose1.22469046
58MP0001545_abnormal_hematopoietic_system1.20345894
59MP0005397_hematopoietic_system_phenotyp1.20345894
60MP0003693_abnormal_embryo_hatching1.19887317
61MP0000858_altered_metastatic_potential1.19793818
62MP0000703_abnormal_thymus_morphology1.19389340
63MP0000716_abnormal_immune_system1.19059240
64MP0002148_abnormal_hypersensitivity_rea1.18259107
65MP0009785_altered_susceptibility_to1.18165236
66MP0010155_abnormal_intestine_physiology1.17862868
67MP0010094_abnormal_chromosome_stability1.17846564
68MP0005023_abnormal_wound_healing1.17788256
69MP0005623_abnormal_meninges_morphology1.15735033
70MP0003111_abnormal_nucleus_morphology1.15492915
71MP0002405_respiratory_system_inflammati1.12106547
72MP0005025_abnormal_response_to1.09972693
73MP0003045_fibrosis1.09692785
74MP0004233_abnormal_muscle_weight1.07379566
75MP0002419_abnormal_innate_immunity1.07221028
76MP0002722_abnormal_immune_system1.07161637
77MP0000015_abnormal_ear_pigmentation1.05827363
78MP0001730_embryonic_growth_arrest1.05436742
79MP0000689_abnormal_spleen_morphology1.05080691
80MP0004957_abnormal_blastocyst_morpholog1.04459449
81MP0002009_preneoplasia1.02933852
82MP0002933_joint_inflammation1.02642178
83MP0002429_abnormal_blood_cell1.02516906
84MP0003283_abnormal_digestive_organ1.02516671
85MP0003183_abnormal_peptide_metabolism1.02182192
86MP0000350_abnormal_cell_proliferation1.02098146
87MP0002928_abnormal_bile_duct1.02072951
88MP0004264_abnormal_extraembryonic_tissu1.01236909
89MP0005310_abnormal_salivary_gland1.00928622
90MP0010368_abnormal_lymphatic_system1.00091611
91MP0001845_abnormal_inflammatory_respons1.00025520
92MP0001915_intracranial_hemorrhage0.99915973
93MP0001533_abnormal_skeleton_physiology0.99548099
94MP0005670_abnormal_white_adipose0.98346606
95MP0001348_abnormal_lacrimal_gland0.97910801
96MP0009333_abnormal_splenocyte_physiolog0.97124323
97MP0002086_abnormal_extraembryonic_tissu0.97047672
98MP0005058_abnormal_lysosome_morphology0.96190819
99MP0008004_abnormal_stomach_pH0.95597775
100MP0000490_abnormal_crypts_of0.94195340
101MP0010630_abnormal_cardiac_muscle0.93980309
102MP0005257_abnormal_intraocular_pressure0.93441734
103MP0001873_stomach_inflammation0.92146326
104MP0003984_embryonic_growth_retardation0.92060126
105MP0003221_abnormal_cardiomyocyte_apopto0.92045920
106MP0002088_abnormal_embryonic_growth/wei0.90969998
107MP0004087_abnormal_muscle_fiber0.90842316
108MP0002332_abnormal_exercise_endurance0.89635917
109MP0008469_abnormal_protein_level0.89203944
110MP0001851_eye_inflammation0.87669888
111MP0001853_heart_inflammation0.86577519
112MP0000371_diluted_coat_color0.86504459
113MP0009840_abnormal_foam_cell0.85830710
114MP0005380_embryogenesis_phenotype0.85784367
115MP0001672_abnormal_embryogenesis/_devel0.85784367
116MP0003690_abnormal_glial_cell0.85765746
117MP0004197_abnormal_fetal_growth/weight/0.85263067
118MP0005621_abnormal_cell_physiology0.85178175
119MP0005375_adipose_tissue_phenotype0.84337425
120MP0000767_abnormal_smooth_muscle0.83214563
121MP0002019_abnormal_tumor_incidence0.82289321
122MP0001958_emphysema0.81557011
123MP0006082_CNS_inflammation0.81213632
124MP0002693_abnormal_pancreas_physiology0.80464549
125MP0001697_abnormal_embryo_size0.80443821
126MP0001879_abnormal_lymphatic_vessel0.79686903
127MP0000343_altered_response_to0.79226067
128MP0008961_abnormal_basal_metabolism0.79199692
129MP0005410_abnormal_fertilization0.78265389
130MP0009764_decreased_sensitivity_to0.77979391
131MP0002998_abnormal_bone_remodeling0.77851526
132MP0002136_abnormal_kidney_physiology0.77562239
133MP0002084_abnormal_developmental_patter0.77514626
134MP0005409_darkened_coat_color0.77457750
135MP0000249_abnormal_blood_vessel0.75236240
136MP0004484_altered_response_of0.74581649
137MP0000604_amyloidosis0.73943177
138MP0002168_other_aberrant_phenotype0.73128939
139MP0006138_congestive_heart_failure0.73106722

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)3.70276096
2Spontaneous hematomas (HP:0007420)3.41899327
3Recurrent gram-negative bacterial infections (HP:0005420)3.39719805
4Abnormality of the fingertips (HP:0001211)3.33432711
5Agammaglobulinemia (HP:0004432)3.16204007
6Nasal polyposis (HP:0100582)3.14761864
7Meningitis (HP:0001287)3.14321263
8Increased density of long bones (HP:0006392)3.03496860
9Cervical subluxation (HP:0003308)2.94708176
10Increased cerebral lipofuscin (HP:0011813)2.92198017
11Abnormality of the nasal mucosa (HP:0000433)2.91525534
12Subacute progressive viral hepatitis (HP:0006572)2.86406412
13Cerebral aneurysm (HP:0004944)2.82140240
14Hematochezia (HP:0002573)2.81549266
15Gingivitis (HP:0000230)2.80170788
16Recurrent bronchitis (HP:0002837)2.75026131
17Gastrointestinal stroma tumor (HP:0100723)2.74985518
18Aortic aneurysm (HP:0004942)2.72724536
19Optic neuritis (HP:0100653)2.71706660
20Retrobulbar optic neuritis (HP:0100654)2.71706660
21Absent frontal sinuses (HP:0002688)2.64933672
22Ulnar deviation of the wrist (HP:0003049)2.59484762
23Increased neuronal autofluorescent lipopigment (HP:0002074)2.58613213
24Autoimmune thrombocytopenia (HP:0001973)2.55602189
25Recurrent skin infections (HP:0001581)2.51825624
26Metaphyseal cupping (HP:0003021)2.50402286
27Dysmetric saccades (HP:0000641)2.47369144
28Asymmetric septal hypertrophy (HP:0001670)2.45691347
29Chronic mucocutaneous candidiasis (HP:0002728)2.39837145
30Recurrent cutaneous fungal infections (HP:0011370)2.39837145
31Centrally nucleated skeletal muscle fibers (HP:0003687)2.37654433
32Recurrent viral infections (HP:0004429)2.32139675
33Gastrointestinal infarctions (HP:0005244)2.31944344
34Abnormality of glycolipid metabolism (HP:0010969)2.30866420
35Abnormality of liposaccharide metabolism (HP:0010968)2.30866420
36Abnormality of glycosphingolipid metabolism (HP:0004343)2.30866420
37Subaortic stenosis (HP:0001682)2.29476686
38Abnormality of the left ventricular outflow tract (HP:0011103)2.29476686
39Stomatitis (HP:0010280)2.27575019
40Malnutrition (HP:0004395)2.25115734
41Bronchitis (HP:0012387)2.23592633
42Eczematoid dermatitis (HP:0000976)2.22974516
43Protrusio acetabuli (HP:0003179)2.22387113
44Persistence of primary teeth (HP:0006335)2.21440615
45Muscle fiber splitting (HP:0003555)2.20065483
46Vacuolated lymphocytes (HP:0001922)2.17961602
47Chronic obstructive pulmonary disease (HP:0006510)2.16056597
48Obstructive lung disease (HP:0006536)2.16056597
49Thin bony cortex (HP:0002753)2.15880544
50Difficulty running (HP:0009046)2.15527326
51Thrombocytosis (HP:0001894)2.14534414
52Keratoconjunctivitis sicca (HP:0001097)2.13749416
53Hemoptysis (HP:0002105)2.13423654
54Abnormality of the calcaneus (HP:0008364)2.13362321
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12853172
56Recurrent pneumonia (HP:0006532)2.12815612
57Hand muscle atrophy (HP:0009130)2.12479766
58Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.09681200
59High pitched voice (HP:0001620)2.08330458
60Abnormality of the vasculature of the conjunctiva (HP:0008054)2.06953144
61Distal lower limb muscle weakness (HP:0009053)2.06386156
62Recurrent fungal infections (HP:0002841)2.06122381
63Nemaline bodies (HP:0003798)2.05522728
64Muscle fiber inclusion bodies (HP:0100299)2.04489856
65Arterial thrombosis (HP:0004420)2.04258668
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.04223972
67Loss of speech (HP:0002371)2.03927538
68Prolonged bleeding time (HP:0003010)2.03605569
69Lymphopenia (HP:0001888)2.03362323
70Hyporeflexia of lower limbs (HP:0002600)2.01310424
71Exercise-induced myalgia (HP:0003738)2.01051174
72Ankle contracture (HP:0006466)2.00220807
73Aortic dissection (HP:0002647)1.99707478
74Aneurysm (HP:0002617)1.99081269
75Myocardial infarction (HP:0001658)1.98551628
76Restrictive lung disease (HP:0002091)1.98308940
77Recurrent abscess formation (HP:0002722)1.98296088
78Abnormality of skeletal muscle fiber size (HP:0012084)1.96520274
79Osteolytic defects of the phalanges of the hand (HP:0009771)1.95725322
80Osteolytic defects of the hand bones (HP:0009699)1.95725322
81Epistaxis (HP:0000421)1.94588923
82Viral hepatitis (HP:0006562)1.93892891
83Ventricular tachycardia (HP:0004756)1.93415269
84Radial bowing (HP:0002986)1.92162292
85Sepsis (HP:0100806)1.90538231
86Upper limb amyotrophy (HP:0009129)1.89556352
87Distal upper limb amyotrophy (HP:0007149)1.89556352
88Encephalitis (HP:0002383)1.89518353
89IgM deficiency (HP:0002850)1.89410681
90Abnormal delayed hypersensitivity skin test (HP:0002963)1.89383810
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89362293
92Recurrent lower respiratory tract infections (HP:0002783)1.89062561
93Frequent falls (HP:0002359)1.88544024
94Abnormality of T cell number (HP:0011839)1.88069979
95Abnormality of B cell number (HP:0010975)1.86874127
96Slow saccadic eye movements (HP:0000514)1.86094508
97IgA deficiency (HP:0002720)1.85767105
98Bundle branch block (HP:0011710)1.84384016
99Amyloidosis (HP:0011034)1.84144796
100Thoracic kyphosis (HP:0002942)1.83341659
101Recurrent sinusitis (HP:0011108)1.83256705
102Panhypogammaglobulinemia (HP:0003139)1.82979155
103Fatigue (HP:0012378)1.82790231
104Keratoconjunctivitis (HP:0001096)1.82582293
105Increased variability in muscle fiber diameter (HP:0003557)1.82343808
106Dysostosis multiplex (HP:0000943)1.81899004
107Micronodular cirrhosis (HP:0001413)1.81686061
108Pulmonary infiltrates (HP:0002113)1.81137518
109Recurrent bacterial skin infections (HP:0005406)1.80827453
110Urticaria (HP:0001025)1.80701227
111Verrucae (HP:0200043)1.80585566
112Papilloma (HP:0012740)1.80585566
113Cellulitis (HP:0100658)1.79771355
114T lymphocytopenia (HP:0005403)1.79629037
115Dislocated radial head (HP:0003083)1.79374965
116Ulnar bowing (HP:0003031)1.79295864
117Upper motor neuron abnormality (HP:0002127)1.78832014
118Bicuspid aortic valve (HP:0001647)1.76776085
119Colitis (HP:0002583)1.75769752
120Volvulus (HP:0002580)1.75488319
121Gastrointestinal carcinoma (HP:0002672)1.73374852
122Malignant gastrointestinal tract tumors (HP:0006749)1.73374852
12311 pairs of ribs (HP:0000878)1.72598693
124Dilatation of the ascending aorta (HP:0005111)1.72371628
125Amaurosis fugax (HP:0100576)1.71893486
126Severe short stature (HP:0003510)1.71884316
127Hypoplastic ischia (HP:0003175)1.71798804
128Missing ribs (HP:0000921)1.71605523
129Prominent nose (HP:0000448)1.70089716
130Emphysema (HP:0002097)1.68685091
131Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.68477981
132Vertebral compression fractures (HP:0002953)1.68139495
133Abnormality of the radial head (HP:0003995)1.68101594
134Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67337531
135Myositis (HP:0100614)1.66671893
136Difficulty climbing stairs (HP:0003551)1.66132404
137Thoracolumbar scoliosis (HP:0002944)1.65271505
138Mediastinal lymphadenopathy (HP:0100721)1.62584687
139Increased connective tissue (HP:0009025)1.61981392
140Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61851685
141Flat acetabular roof (HP:0003180)1.61646985
142Tubular atrophy (HP:0000092)1.61441541
143Cutaneous melanoma (HP:0012056)1.61287855
144Premature rupture of membranes (HP:0001788)1.60624878
145Abnormal foot bone ossification (HP:0010675)1.60571587
146Exostoses (HP:0100777)1.59826517
147Long eyelashes (HP:0000527)1.59070535
148Gastrointestinal inflammation (HP:0004386)1.58893491
149Periodontitis (HP:0000704)1.58305897
150Broad thumb (HP:0011304)1.58277661
151Vasculitis (HP:0002633)1.58222006
152Inflammation of the large intestine (HP:0002037)1.57430193
153Abnormality of cells of the lymphoid lineage (HP:0012140)1.57404818
154Chest pain (HP:0100749)1.55993910
155Limited elbow extension (HP:0001377)1.55911613
156Transitional cell carcinoma of the bladder (HP:0006740)1.55245973
157Type 1 muscle fiber predominance (HP:0003803)1.53921399
158Spondylolisthesis (HP:0003302)1.52595077
159Mitral valve prolapse (HP:0001634)1.52242587
160Osteomyelitis (HP:0002754)1.52066743
161Orchitis (HP:0100796)1.51378641
162Elevated erythrocyte sedimentation rate (HP:0003565)1.51162708
163Selective tooth agenesis (HP:0001592)1.50766616
164Truncal obesity (HP:0001956)1.50350718
165Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.49789755
166Short 4th metacarpal (HP:0010044)1.49789755
167Rectal prolapse (HP:0002035)1.49101465
168Wrist flexion contracture (HP:0001239)1.47697820
169Tibial bowing (HP:0002982)1.47630984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK122.88483816
2MAP3K102.82251896
3BLK2.77086863
4TTN2.71322053
5TRIB32.68321797
6PRPF4B2.51940043
7MAP3K142.40444420
8PKN22.39794754
9JAK32.33920488
10MAP4K12.21909614
11TYK22.21201548
12NEK22.10675803
13PTK62.04155454
14IRAK41.94236028
15EEF2K1.93436849
16PASK1.89946082
17STK101.82011081
18PRKD31.61219135
19TBK11.58024016
20FES1.54124323
21PDK31.54007925
22PDK41.54007925
23JAK11.53805051
24CHUK1.52987564
25ERN11.51076788
26RPS6KA41.50655426
27RIPK11.47965209
28STK31.45188863
29FLT31.43292379
30TESK11.42903655
31FRK1.37412265
32FGFR31.34094572
33FGFR41.33725810
34CDC71.31588716
35KSR21.31522041
36TEC1.29169281
37ZAP701.25314158
38FGR1.24810564
39LRRK21.24098173
40PDGFRA1.21456207
41LATS11.19957172
42SCYL21.17839547
43MARK21.17158994
44STK241.17014918
45CDK191.16062505
46IKBKB1.14737953
47TAOK31.14363050
48PIM11.14103265
49OBSCN1.13916477
50MAP3K71.13730277
51CDC42BPA1.12010080
52MAP3K131.07932574
53STK38L1.06865585
54TNK21.04083678
55CSK1.03164356
56CAMK1D1.00749602
57MTOR1.00173256
58IKBKE0.99603365
59MAPK70.96138161
60TGFBR10.96119113
61LYN0.95298160
62EPHA30.94732282
63PAK40.94693717
64CDK40.93267928
65CDK60.92594517
66MARK30.89619986
67MAP3K80.87957482
68MELK0.87370356
69DYRK1B0.86398329
70PDK10.86309837
71MAP3K30.85320226
72ICK0.84757560
73DMPK0.84506800
74SGK30.83091164
75BMX0.82750193
76GRK60.82296858
77NEK90.81833953
78MAPK120.79396973
79KIT0.78554141
80MAP2K30.78553637
81PDPK10.77578832
82MATK0.77447885
83SMG10.77307004
84RPS6KL10.77230458
85RPS6KC10.77230458
86STK40.77072923
87NEK10.76281864
88BTK0.75752844
89MAP3K10.75718155
90MAP3K60.75632025
91IRAK20.75533321
92CDK90.75260636
93PAK20.74429295
94IRAK30.73791796
95PDK20.73743165
96CAMK1G0.71485729
97WNK40.70046072
98ATR0.69621071
99IRAK10.68150436
100ITK0.67004861
101HIPK20.66205800
102BMPR20.66167360
103RET0.66124816
104SGK20.65564614
105EPHB10.65531315
106HCK0.64726442
107PTK20.64538447
108TGFBR20.63994128
109TAOK10.63483392
110RPS6KA60.63374019
111PRKAA20.63244523
112PDGFRB0.63188472
113MOS0.62840056
114RIPK40.62516391
115JAK20.62286901
116CSF1R0.62094917
117PRKD20.57014469
118PIK3CG0.56629735
119TTK0.56336960
120MAPK40.56266773
121MAPK110.55767041
122ACVR1B0.55475974
123NLK0.55325732
124CHEK10.54883615
125MYLK0.54523898
126LCK0.54140353
127BRD40.52265177
128YES10.51372139
129AURKB0.51340792
130CAMK40.50777797
131STK380.50081050
132TRPM70.48783410
133ALK0.45799930
134SYK0.44744167
135EPHA20.42855962
136ATM0.42798834
137RPS6KB20.42299266
138PTK2B0.41236028
139EGFR0.40676322
140NUAK10.39958805
141PIM20.39086618

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.13601687
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.05986749
3Antigen processing and presentation_Homo sapiens_hsa046121.93202259
4Leishmaniasis_Homo sapiens_hsa051401.73034143
5Measles_Homo sapiens_hsa051621.69576140
6Asthma_Homo sapiens_hsa053101.67581379
7Osteoclast differentiation_Homo sapiens_hsa043801.65320558
8B cell receptor signaling pathway_Homo sapiens_hsa046621.65141825
9Toxoplasmosis_Homo sapiens_hsa051451.64492846
10Small cell lung cancer_Homo sapiens_hsa052221.62966807
11Herpes simplex infection_Homo sapiens_hsa051681.56701567
12Chronic myeloid leukemia_Homo sapiens_hsa052201.49706900
13Viral myocarditis_Homo sapiens_hsa054161.49058461
14Influenza A_Homo sapiens_hsa051641.48515710
15TNF signaling pathway_Homo sapiens_hsa046681.46576987
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45678855
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.43179880
18Legionellosis_Homo sapiens_hsa051341.41313852
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40994910
20Viral carcinogenesis_Homo sapiens_hsa052031.40721827
21Apoptosis_Homo sapiens_hsa042101.33614054
22p53 signaling pathway_Homo sapiens_hsa041151.32083215
23Allograft rejection_Homo sapiens_hsa053301.30750671
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28027679
25Shigellosis_Homo sapiens_hsa051311.27517680
26Primary immunodeficiency_Homo sapiens_hsa053401.27102154
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26680689
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26534509
29MicroRNAs in cancer_Homo sapiens_hsa052061.26202604
30Hepatitis B_Homo sapiens_hsa051611.25541772
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24591887
32HTLV-I infection_Homo sapiens_hsa051661.20034435
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19348492
34Pancreatic cancer_Homo sapiens_hsa052121.19003259
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.18709241
36Focal adhesion_Homo sapiens_hsa045101.17586728
37Leukocyte transendothelial migration_Homo sapiens_hsa046701.17096587
38Acute myeloid leukemia_Homo sapiens_hsa052211.15248752
39mTOR signaling pathway_Homo sapiens_hsa041501.14548844
40Adherens junction_Homo sapiens_hsa045201.14386796
41T cell receptor signaling pathway_Homo sapiens_hsa046601.13328576
42Cell cycle_Homo sapiens_hsa041101.10395062
43Proteoglycans in cancer_Homo sapiens_hsa052051.08147437
44Prolactin signaling pathway_Homo sapiens_hsa049171.07378580
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07220224
46Insulin resistance_Homo sapiens_hsa049311.06107365
47Type I diabetes mellitus_Homo sapiens_hsa049401.04748248
48Epstein-Barr virus infection_Homo sapiens_hsa051691.01959326
49Lysosome_Homo sapiens_hsa041421.01372927
50Tuberculosis_Homo sapiens_hsa051521.01339450
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00607552
52Type II diabetes mellitus_Homo sapiens_hsa049300.99037916
53Renal cell carcinoma_Homo sapiens_hsa052110.97444649
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95922510
55Dorso-ventral axis formation_Homo sapiens_hsa043200.93910393
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92131464
57Systemic lupus erythematosus_Homo sapiens_hsa053220.92060293
58Graft-versus-host disease_Homo sapiens_hsa053320.91599336
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.91287124
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89760478
61Pertussis_Homo sapiens_hsa051330.89270378
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.87619252
63Hematopoietic cell lineage_Homo sapiens_hsa046400.86864933
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86076315
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.85931681
66Chemokine signaling pathway_Homo sapiens_hsa040620.85347542
67FoxO signaling pathway_Homo sapiens_hsa040680.84406309
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84023534
69ECM-receptor interaction_Homo sapiens_hsa045120.84016320
70RNA transport_Homo sapiens_hsa030130.81920412
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.81914544
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81875544
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.80356799
74Prostate cancer_Homo sapiens_hsa052150.79817321
75Lysine degradation_Homo sapiens_hsa003100.79559396
76HIF-1 signaling pathway_Homo sapiens_hsa040660.79539861
77Phagosome_Homo sapiens_hsa041450.79296087
78Amoebiasis_Homo sapiens_hsa051460.79133692
79VEGF signaling pathway_Homo sapiens_hsa043700.78539043
80Platelet activation_Homo sapiens_hsa046110.78108772
81African trypanosomiasis_Homo sapiens_hsa051430.77583179
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77416822
83Hepatitis C_Homo sapiens_hsa051600.77072661
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77044305
85Notch signaling pathway_Homo sapiens_hsa043300.76956126
86Malaria_Homo sapiens_hsa051440.76680441
87Salmonella infection_Homo sapiens_hsa051320.76613819
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76393099
89Colorectal cancer_Homo sapiens_hsa052100.75933820
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73118812
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72018081
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.71690067
93Choline metabolism in cancer_Homo sapiens_hsa052310.71284898
94mRNA surveillance pathway_Homo sapiens_hsa030150.71169214
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70129287
96One carbon pool by folate_Homo sapiens_hsa006700.68164706
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.67748254
98Endometrial cancer_Homo sapiens_hsa052130.67520904
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67359546
100Other glycan degradation_Homo sapiens_hsa005110.66928877
101Bladder cancer_Homo sapiens_hsa052190.66171505
102Autoimmune thyroid disease_Homo sapiens_hsa053200.66064475
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65896075
104Insulin signaling pathway_Homo sapiens_hsa049100.64830309
105Dilated cardiomyopathy_Homo sapiens_hsa054140.64790110
106Non-small cell lung cancer_Homo sapiens_hsa052230.62944899
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62124536
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60208850
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60002105
110Pathways in cancer_Homo sapiens_hsa052000.59677315
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.58011468
112Rheumatoid arthritis_Homo sapiens_hsa053230.57809688
113ErbB signaling pathway_Homo sapiens_hsa040120.56461193
114Inositol phosphate metabolism_Homo sapiens_hsa005620.55625863
115Glioma_Homo sapiens_hsa052140.55170980
116Selenocompound metabolism_Homo sapiens_hsa004500.55041188
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55026524
118GnRH signaling pathway_Homo sapiens_hsa049120.54039523

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