TBC1D10A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.78935360
2negative regulation of cell killing (GO:0031342)5.78935360
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.07593376
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.03804033
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.03804033
6antigen processing and presentation of endogenous antigen (GO:0019883)4.71090385
7leukocyte aggregation (GO:0070486)4.35403127
8hemidesmosome assembly (GO:0031581)4.24037525
9interferon-gamma secretion (GO:0072643)4.20433066
10regulation of B cell receptor signaling pathway (GO:0050855)3.87053479
11T cell migration (GO:0072678)3.75592434
12NIK/NF-kappaB signaling (GO:0038061)3.75220951
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.74866292
14positive regulation by symbiont of host defense response (GO:0052509)3.72255850
15modulation by symbiont of host defense response (GO:0052031)3.72255850
16modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.72255850
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.72255850
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.72255850
19modulation by symbiont of host immune response (GO:0052553)3.72255850
20tolerance induction (GO:0002507)3.63665706
21detection of bacterium (GO:0016045)3.60562061
22detection of other organism (GO:0098543)3.56607471
23immunoglobulin mediated immune response (GO:0016064)3.49920278
24regulation of T cell tolerance induction (GO:0002664)3.46174774
25response to interleukin-15 (GO:0070672)3.40513949
26negative regulation of interleukin-12 production (GO:0032695)3.39699703
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.38023079
28regulation of gamma-delta T cell differentiation (GO:0045586)3.34593353
29regulation of cholesterol homeostasis (GO:2000188)3.31693806
30desmosome organization (GO:0002934)3.31423136
31cellular response to interleukin-15 (GO:0071350)3.31131958
32negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.30280978
33type I interferon signaling pathway (GO:0060337)3.30104452
34cellular response to type I interferon (GO:0071357)3.30104452
35response to type I interferon (GO:0034340)3.27976641
36positive T cell selection (GO:0043368)3.27286098
37response to peptidoglycan (GO:0032494)3.26244428
38positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.25076386
39negative regulation of T cell mediated immunity (GO:0002710)3.23681797
40regulation of T cell mediated cytotoxicity (GO:0001914)3.22876544
41negative regulation of leukocyte mediated immunity (GO:0002704)3.18185272
42thymic T cell selection (GO:0045061)3.17981282
43regulation of natural killer cell mediated immunity (GO:0002715)3.14241125
44regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.14241125
45positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11269908
46neutrophil activation involved in immune response (GO:0002283)3.11214060
47skin morphogenesis (GO:0043589)3.11095640
48positive thymic T cell selection (GO:0045059)3.08890607
49epithelial cell-cell adhesion (GO:0090136)3.08502434
50macrophage activation involved in immune response (GO:0002281)3.04396857
51Golgi transport vesicle coating (GO:0048200)3.03443640
52COPI coating of Golgi vesicle (GO:0048205)3.03443640
53positive regulation of B cell differentiation (GO:0045579)3.03305006
54regulation of B cell differentiation (GO:0045577)3.01727027
55regulation of interleukin-12 biosynthetic process (GO:0045075)3.01414054
56regulation of tolerance induction (GO:0002643)3.01219185
57regulation of T-helper 2 cell differentiation (GO:0045628)3.00753755
58regulation of gamma-delta T cell activation (GO:0046643)3.00438053
59positive regulation of gamma-delta T cell activation (GO:0046645)2.99895068
60regulation of interferon-beta biosynthetic process (GO:0045357)2.99442592
61regulation of alpha-beta T cell proliferation (GO:0046640)2.98844811
62regulation of regulatory T cell differentiation (GO:0045589)2.93480982
63antigen processing and presentation via MHC class Ib (GO:0002475)2.91826296
64germinal center formation (GO:0002467)2.88931763
65positive regulation of tolerance induction (GO:0002645)2.88263993
66negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87491802
67regulation of interleukin-2 biosynthetic process (GO:0045076)2.85877951
68regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.84818473
69neutrophil activation (GO:0042119)2.83365139
70response to laminar fluid shear stress (GO:0034616)2.82983107
71regulation of leukocyte mediated cytotoxicity (GO:0001910)2.81133607
72cell-substrate junction assembly (GO:0007044)2.80865671
73detection of external biotic stimulus (GO:0098581)2.76828046
74granulocyte activation (GO:0036230)2.76651677
75positive regulation of interleukin-2 production (GO:0032743)2.75532993
76B cell receptor signaling pathway (GO:0050853)2.75329637
77regulation of hippo signaling (GO:0035330)2.74781979
78regulation of translational termination (GO:0006449)2.74667865
79apoptotic cell clearance (GO:0043277)2.74595898
80JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.74095131
81negative regulation of cytokine production involved in immune response (GO:0002719)2.72178917
82endothelial tube morphogenesis (GO:0061154)2.72077004
83morphogenesis of an endothelium (GO:0003159)2.72077004
84negative regulation of interleukin-6 production (GO:0032715)2.71866045
85regulation of water loss via skin (GO:0033561)2.71097975
86positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.70948550
87negative regulation of stress fiber assembly (GO:0051497)2.70291341
88regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70235533
89regulation of dendritic cell antigen processing and presentation (GO:0002604)2.70019790
90regulation of defense response to virus by virus (GO:0050690)2.69338552
91lymphocyte migration (GO:0072676)2.69195452
92negative thymic T cell selection (GO:0045060)2.68912618
93defense response to protozoan (GO:0042832)2.68776428
94negative regulation of T-helper cell differentiation (GO:0045623)2.68550250
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68550250
96T cell receptor signaling pathway (GO:0050852)2.67555234
97interferon-gamma-mediated signaling pathway (GO:0060333)2.67011490
98regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.63537108
99hair cycle (GO:0042633)2.62438962
100molting cycle (GO:0042303)2.62438962
101negative regulation of type 2 immune response (GO:0002829)2.61630426
102myeloid dendritic cell differentiation (GO:0043011)2.61435951
103T cell apoptotic process (GO:0070231)2.61105146
104respiratory burst (GO:0045730)2.60452538
105positive regulation of natural killer cell differentiation (GO:0032825)2.60135558
106actin nucleation (GO:0045010)2.59491314
107mannose metabolic process (GO:0006013)2.59475418
108CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.59385701
109T-helper cell differentiation (GO:0042093)2.59385701
110cellular extravasation (GO:0045123)2.59348827
111regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.59307196
112antigen receptor-mediated signaling pathway (GO:0050851)2.59243866
113response to protozoan (GO:0001562)2.59072339
114regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59061137
115folic acid-containing compound biosynthetic process (GO:0009396)2.58736650
116regulation of cell killing (GO:0031341)2.58669944
117regulation of antigen processing and presentation (GO:0002577)2.58010879
118negative T cell selection (GO:0043383)2.57579353
119activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.54147776
120negative regulation of erythrocyte differentiation (GO:0045647)2.51609340
121maternal placenta development (GO:0001893)2.51368381
122Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50765529
123regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.49722769
124positive regulation of SMAD protein import into nucleus (GO:0060391)2.47578093
125positive regulation of nuclease activity (GO:0032075)2.47385897
126T cell selection (GO:0045058)2.47070998
127natural killer cell differentiation (GO:0001779)2.46878913
128maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.46737046
129regulation of SMAD protein import into nucleus (GO:0060390)2.44509454
130apoptotic process involved in morphogenesis (GO:0060561)2.43363710
131type B pancreatic cell proliferation (GO:0044342)2.38980831
132cell migration involved in sprouting angiogenesis (GO:0002042)2.37700728
133positive regulation of lamellipodium assembly (GO:0010592)2.35554070
134protein retention in ER lumen (GO:0006621)2.34864936
135regulation of response to interferon-gamma (GO:0060330)2.33916823
136growth hormone receptor signaling pathway (GO:0060396)2.33223093
137trophectodermal cell differentiation (GO:0001829)2.32240810
138endodermal cell differentiation (GO:0035987)2.31881427
139negative regulation of glycoprotein biosynthetic process (GO:0010561)2.31011165
140negative regulation of innate immune response (GO:0045824)2.30096190
141cysteine metabolic process (GO:0006534)2.29607100
142establishment of skin barrier (GO:0061436)2.29354080
1434-hydroxyproline metabolic process (GO:0019471)2.28799000
144positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.27967141
145regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.27861477
146regulation of natural killer cell differentiation (GO:0032823)2.26774636
147valine metabolic process (GO:0006573)2.26244110
148regulation of gene silencing by RNA (GO:0060966)2.25979445
149regulation of posttranscriptional gene silencing (GO:0060147)2.25979445
150regulation of gene silencing by miRNA (GO:0060964)2.25979445
151cellular response to nutrient (GO:0031670)2.25098384
152platelet aggregation (GO:0070527)2.24871724
153blood vessel endothelial cell migration (GO:0043534)2.23942735
154positive regulation of p38MAPK cascade (GO:1900745)2.23885707
155regulation of nuclease activity (GO:0032069)2.23293721
156basement membrane organization (GO:0071711)2.23254757
157folic acid metabolic process (GO:0046655)2.23219534
158epithelial cell differentiation involved in prostate gland development (GO:0060742)2.23121409
159response to muramyl dipeptide (GO:0032495)2.20281652
160positive regulation of triglyceride biosynthetic process (GO:0010867)2.20166759
161regulation of early endosome to late endosome transport (GO:2000641)2.20049751
162positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.18477097
163endoplasmic reticulum unfolded protein response (GO:0030968)2.18301360
164positive regulation of histone deacetylation (GO:0031065)2.17993131
165lymphocyte apoptotic process (GO:0070227)2.17485052
166nodal signaling pathway (GO:0038092)2.16430482
167negative regulation of lipid transport (GO:0032369)2.16337017
168regulation of tight junction assembly (GO:2000810)2.15902748
169low-density lipoprotein particle clearance (GO:0034383)2.15510050
170formation of translation preinitiation complex (GO:0001731)2.15450131
171cell adhesion mediated by integrin (GO:0033627)2.15082954
172barbed-end actin filament capping (GO:0051016)2.14807970
173tricarboxylic acid metabolic process (GO:0072350)2.12135513
174proline biosynthetic process (GO:0006561)2.11131785
175negative regulation of sterol transport (GO:0032372)2.10255974
176negative regulation of cholesterol transport (GO:0032375)2.10255974
177endothelial cell chemotaxis (GO:0035767)2.09354407
178regulation of translational fidelity (GO:0006450)2.08425696
179positive regulation of lamellipodium organization (GO:1902745)2.07812577

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.58226725
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.28204245
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99247114
4MYC_22102868_ChIP-Seq_BL_Human2.62180485
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.54790584
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.49127920
7ZNF263_19887448_ChIP-Seq_K562_Human2.40895671
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.37671536
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.33222313
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29024600
11RUNX_20019798_ChIP-Seq_JUKART_Human2.25067673
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.18623918
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.17797239
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06663654
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.00570466
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99583887
17VDR_21846776_ChIP-Seq_THP-1_Human1.99505109
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.99365640
19CLOCK_20551151_ChIP-Seq_293T_Human1.94131900
20* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.91361086
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89627550
22MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.89223493
23E2F7_22180533_ChIP-Seq_HELA_Human1.87579222
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83726222
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79656913
26TCF7_22412390_ChIP-Seq_EML_Mouse1.77727673
27SPI1_23547873_ChIP-Seq_NB4_Human1.76616060
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76548199
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74801296
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.73696723
31LXR_22292898_ChIP-Seq_THP-1_Human1.72898305
32* RXR_22158963_ChIP-Seq_LIVER_Mouse1.70999061
33* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.67815429
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67727073
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66088809
36SPI1_23127762_ChIP-Seq_K562_Human1.64473255
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.64232057
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63598835
39RACK7_27058665_Chip-Seq_MCF-7_Human1.63519978
40MAF_26560356_Chip-Seq_TH1_Human1.62064753
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60606974
42ATF3_27146783_Chip-Seq_COLON_Human1.59825049
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59732483
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59366885
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57938922
46KDM2B_26808549_Chip-Seq_DND41_Human1.55875031
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49869895
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49569727
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49037962
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49019363
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44933006
52SCL_19346495_ChIP-Seq_HPC-7_Human1.44552526
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44387448
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.43850175
55POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43593511
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41237666
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40984305
58* GATA3_27048872_Chip-Seq_THYMUS_Human1.40949885
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.38738741
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37004408
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35626070
62* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35490018
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35427157
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.35425091
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34527157
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33852463
67* UTX_26944678_Chip-Seq_JUKART_Human1.33684826
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33162636
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31661564
70MYC_18555785_ChIP-Seq_MESCs_Mouse1.30399252
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29192758
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28445295
73ESR1_21235772_ChIP-Seq_MCF-7_Human1.27535316
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27253836
75* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25817376
76PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25364975
77BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24605343
78NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23831393
79GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22112617
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21731551
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20452271
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20167110
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20100295
84MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19977087
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18957097
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18908877
87FOXM1_23109430_ChIP-Seq_U2OS_Human1.17949146
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17574514
89GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16346192
90MYB_26560356_Chip-Seq_TH2_Human1.15237618
91LXR_22158963_ChIP-Seq_LIVER_Mouse1.14809925
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14645163
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14295538
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13137314
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12600288
96* TET1_21451524_ChIP-Seq_MESCs_Mouse1.12368216
97TRIM28_21343339_ChIP-Seq_HEK293_Human1.12122319
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11187188
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10978788
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10855555
101SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.10682080
102MYB_26560356_Chip-Seq_TH1_Human1.10665901
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.09171071
104NCOR1_26117541_ChIP-Seq_K562_Human1.09155734
105* MAF_26560356_Chip-Seq_TH2_Human1.08419964
106VDR_24763502_ChIP-Seq_THP-1_Human1.08151168
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07128426
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06968302
109TCF3_18692474_ChIP-Seq_MEFs_Mouse1.06435708
110GATA2_21666600_ChIP-Seq_HMVEC_Human1.05912257
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05423424
112FOXO3_23340844_ChIP-Seq_DLD1_Human1.05003215
113P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04304293
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03456431
115SMC4_20622854_ChIP-Seq_HELA_Human1.02997664
116SA1_27219007_Chip-Seq_ERYTHROID_Human1.02499462
117* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02322342
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01420486
119TFEB_21752829_ChIP-Seq_HELA_Human1.01355758
120* CTCF_26484167_Chip-Seq_Bcells_Mouse1.00974091
121NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00968728
122* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00945491
123FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00924495
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00075173
125P68_20966046_ChIP-Seq_HELA_Human0.99920385
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99665220
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99206563
128MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98722108
129KDM2B_26808549_Chip-Seq_JURKAT_Human0.97899588
130BCL6_27268052_Chip-Seq_Bcells_Human0.97891477
131CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97793023
132GATA1_19941826_ChIP-Seq_K562_Human0.97790044
133RUNX1_22412390_ChIP-Seq_EML_Mouse0.97553013
134BCOR_27268052_Chip-Seq_Bcells_Human0.96586951
135CTCF_21964334_Chip-Seq_Bcells_Human0.96397230
136* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95348448
137SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95332532
138KDM2B_26808549_Chip-Seq_K562_Human0.95251362
139STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95233396
140DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94559895
141ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94332595
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93949192
143PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93798836
144OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93647760
145SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93232202
146SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93232202
147TP53_22127205_ChIP-Seq_IMR90_Human0.93204780
148ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92869940
149FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92274432
150ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92209543
151UBF1/2_26484160_Chip-Seq_HMECs_Human0.92011928

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.67164566
2MP0003705_abnormal_hypodermis_morpholog3.66133984
3MP0003724_increased_susceptibility_to3.55808359
4MP0010234_abnormal_vibrissa_follicle3.06277145
5MP0010352_gastrointestinal_tract_polyps2.71641124
6MP0009785_altered_susceptibility_to2.68267695
7MP0003566_abnormal_cell_adhesion2.62784286
8MP0002419_abnormal_innate_immunity2.58923535
9MP0009840_abnormal_foam_cell2.55911888
10MP0005275_abnormal_skin_tensile2.48713339
11MP0002148_abnormal_hypersensitivity_rea2.35634590
12MP0000685_abnormal_immune_system2.30989951
13MP0002796_impaired_skin_barrier2.19744141
14MP0004947_skin_inflammation2.10709028
15MP0005023_abnormal_wound_healing1.94131727
16MP0003763_abnormal_thymus_physiology1.88502390
17MP0005076_abnormal_cell_differentiation1.84024520
18MP0003436_decreased_susceptibility_to1.80916427
19MP0003453_abnormal_keratinocyte_physiol1.80381197
20MP0008260_abnormal_autophagy1.79284593
21MP0002138_abnormal_hepatobiliary_system1.78967569
22MP0003172_abnormal_lysosome_physiology1.77495246
23MP0004381_abnormal_hair_follicle1.77059684
24MP0003300_gastrointestinal_ulcer1.69414379
25MP0005464_abnormal_platelet_physiology1.64225677
26MP0002139_abnormal_hepatobiliary_system1.59617362
27MP0005360_urolithiasis1.59545877
28MP0008438_abnormal_cutaneous_collagen1.57501681
29MP0001849_ear_inflammation1.56828106
30MP0003866_abnormal_defecation1.52439572
31MP0000465_gastrointestinal_hemorrhage1.48717604
32MP0005501_abnormal_skin_physiology1.48442714
33MP0002060_abnormal_skin_morphology1.47513601
34MP0003191_abnormal_cellular_cholesterol1.47074226
35MP0002166_altered_tumor_susceptibility1.45378269
36MP0005451_abnormal_body_composition1.43860094
37MP0001216_abnormal_epidermal_layer1.42434428
38MP0002429_abnormal_blood_cell1.42117825
39MP0002877_abnormal_melanocyte_morpholog1.42020212
40MP0002998_abnormal_bone_remodeling1.36694698
41MP0008469_abnormal_protein_level1.36415360
42MP0001835_abnormal_antigen_presentation1.33299539
43MP0003303_peritoneal_inflammation1.33167044
44MP0005075_abnormal_melanosome_morpholog1.32717613
45MP0001853_heart_inflammation1.32649664
46MP0009764_decreased_sensitivity_to1.32489752
47MP0009278_abnormal_bone_marrow1.31898021
48MP0003828_pulmonary_edema1.31313863
49MP0000858_altered_metastatic_potential1.30142410
50MP0005310_abnormal_salivary_gland1.28305618
51MP0003806_abnormal_nucleotide_metabolis1.28258078
52MP0003075_altered_response_to1.27322669
53MP0001243_abnormal_dermal_layer1.25814657
54MP0001958_emphysema1.23061416
55MP0004510_myositis1.14706174
56MP0001348_abnormal_lacrimal_gland1.12690006
57MP0003091_abnormal_cell_migration1.11903741
58MP0001873_stomach_inflammation1.11059885
59MP0001790_abnormal_immune_system1.10448776
60MP0005387_immune_system_phenotype1.10448776
61MP0002006_tumorigenesis1.09846565
62MP0001851_eye_inflammation1.09404028
63MP0000377_abnormal_hair_follicle1.09183120
64MP0009333_abnormal_splenocyte_physiolog1.09147757
65MP0001800_abnormal_humoral_immune1.06781082
66MP0010155_abnormal_intestine_physiology1.04714328
67MP0010307_abnormal_tumor_latency1.03774523
68MP0003693_abnormal_embryo_hatching1.03359094
69MP0000604_amyloidosis1.03046940
70MP0005390_skeleton_phenotype1.02643370
71MP0003183_abnormal_peptide_metabolism1.00286812
72MP0000609_abnormal_liver_physiology0.99644893
73MP0002452_abnormal_antigen_presenting0.98754311
74MP0002405_respiratory_system_inflammati0.98011907
75MP0005000_abnormal_immune_tolerance0.97326475
76MP0009643_abnormal_urine_homeostasis0.96538904
77MP0009384_cardiac_valve_regurgitation0.96155948
78MP0005058_abnormal_lysosome_morphology0.95311604
79MP0002136_abnormal_kidney_physiology0.95289176
80MP0003279_aneurysm0.95247253
81MP0002098_abnormal_vibrissa_morphology0.95086758
82MP0000703_abnormal_thymus_morphology0.94851973
83MP0001545_abnormal_hematopoietic_system0.94366680
84MP0005397_hematopoietic_system_phenotyp0.94366680
85MP0002089_abnormal_postnatal_growth/wei0.94211825
86MP0009931_abnormal_skin_appearance0.94165678
87MP0005166_decreased_susceptibility_to0.93783799
88MP0002722_abnormal_immune_system0.92994978
89MP0001533_abnormal_skeleton_physiology0.92274197
90MP0002398_abnormal_bone_marrow0.92087471
91MP0005671_abnormal_response_to0.91679669
92MP0002396_abnormal_hematopoietic_system0.91469919
93MP0001819_abnormal_immune_cell0.89886440
94MP0001845_abnormal_inflammatory_respons0.89739560
95MP0002420_abnormal_adaptive_immunity0.89198524
96MP0002723_abnormal_immune_serum0.89184618
97MP0003878_abnormal_ear_physiology0.88876842
98MP0005377_hearing/vestibular/ear_phenot0.88876842
99MP0005365_abnormal_bile_salt0.88801146
100MP0000579_abnormal_nail_morphology0.88448263
101MP0003941_abnormal_skin_development0.87516488
102MP0003448_altered_tumor_morphology0.87487230
103MP0000343_altered_response_to0.86805072
104MP0006054_spinal_hemorrhage0.86553638
105MP0006082_CNS_inflammation0.86347101
106MP0008007_abnormal_cellular_replicative0.85816210
107MP0008004_abnormal_stomach_pH0.85383406
108MP0010678_abnormal_skin_adnexa0.85229537
109MP0003252_abnormal_bile_duct0.85140408
110MP0000689_abnormal_spleen_morphology0.84860712
111MP0002933_joint_inflammation0.84581242
112MP0008961_abnormal_basal_metabolism0.84391320
113MP0004264_abnormal_extraembryonic_tissu0.82367458
114MP0004019_abnormal_vitamin_homeostasis0.82247291
115MP0005025_abnormal_response_to0.82090391
116MP0003045_fibrosis0.82061078
117MP0004957_abnormal_blastocyst_morpholog0.81717153
118MP0001542_abnormal_bone_strength0.81702777
119MP0004883_abnormal_blood_vessel0.81560596
120MP0000716_abnormal_immune_system0.81407716
121MP0000015_abnormal_ear_pigmentation0.81273578
122MP0002132_abnormal_respiratory_system0.81153398
123MP0004185_abnormal_adipocyte_glucose0.80850993
124MP0004808_abnormal_hematopoietic_stem0.79865961
125MP0001191_abnormal_skin_condition0.79489097
126MP0009763_increased_sensitivity_to0.78921842
127MP0002277_abnormal_respiratory_mucosa0.77914198
128MP0001663_abnormal_digestive_system0.77858934
129MP0009053_abnormal_anal_canal0.77807217
130MP0003795_abnormal_bone_structure0.77443111
131MP0000467_abnormal_esophagus_morphology0.76628687
132MP0000249_abnormal_blood_vessel0.76472649
133MP0005085_abnormal_gallbladder_physiolo0.76437257
134MP0000733_abnormal_muscle_development0.75972167
135MP0010030_abnormal_orbit_morphology0.75621956
136MP0000350_abnormal_cell_proliferation0.75594290
137MP0005164_abnormal_response_to0.72257123
138MP0004858_abnormal_nervous_system0.66218837
139MP0003690_abnormal_glial_cell0.63992837
140MP0003329_amyloid_beta_deposits0.63967690
141MP0000490_abnormal_crypts_of0.63872085
142MP0008874_decreased_physiological_sensi0.62960058
143MP0000767_abnormal_smooth_muscle0.60765284
144MP0003656_abnormal_erythrocyte_physiolo0.59558814

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)4.63435543
2Myositis (HP:0100614)4.56207546
3Recurrent bacterial skin infections (HP:0005406)4.51536166
4Recurrent abscess formation (HP:0002722)4.37243540
5Orchitis (HP:0100796)3.94127608
6Stomatitis (HP:0010280)3.91926265
7Protrusio acetabuli (HP:0003179)3.55218946
8Retrobulbar optic neuritis (HP:0100654)3.52774427
9Optic neuritis (HP:0100653)3.52774427
10Recurrent fungal infections (HP:0002841)3.48360117
11Mediastinal lymphadenopathy (HP:0100721)3.47431398
12Cerebral aneurysm (HP:0004944)3.45618891
13Abnormality of glycolipid metabolism (HP:0010969)3.42740518
14Abnormality of liposaccharide metabolism (HP:0010968)3.42740518
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.42740518
16T lymphocytopenia (HP:0005403)3.21551028
17Dysostosis multiplex (HP:0000943)3.20557256
18Gastrointestinal infarctions (HP:0005244)3.18184266
19Meningitis (HP:0001287)3.13247838
20Increased IgM level (HP:0003496)3.10294632
21Milia (HP:0001056)3.08922158
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.07978855
23Hand muscle atrophy (HP:0009130)3.07954803
24Increased cerebral lipofuscin (HP:0011813)3.01017520
25Recurrent skin infections (HP:0001581)3.00042592
26Abnormality of T cell number (HP:0011839)2.92660780
27Vasculitis (HP:0002633)2.92165653
28Aortic aneurysm (HP:0004942)2.91432197
29Encephalitis (HP:0002383)2.90992503
30Obstructive lung disease (HP:0006536)2.89049369
31Chronic obstructive pulmonary disease (HP:0006510)2.89049369
32Recurrent gram-negative bacterial infections (HP:0005420)2.88473336
33Abnormality of the nasal mucosa (HP:0000433)2.87170431
34Distal upper limb amyotrophy (HP:0007149)2.83443950
35Upper limb amyotrophy (HP:0009129)2.83443950
36Atrophic scars (HP:0001075)2.83073306
37Cervical subluxation (HP:0003308)2.82923680
38Recurrent viral infections (HP:0004429)2.82484083
39Ankle contracture (HP:0006466)2.82255871
40Vacuolated lymphocytes (HP:0001922)2.82215781
41Pili torti (HP:0003777)2.80897847
42Selective tooth agenesis (HP:0001592)2.77739907
43Increased IgE level (HP:0003212)2.77122055
44Hypergammaglobulinemia (HP:0010702)2.74288854
45Loss of speech (HP:0002371)2.70611842
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.69379075
47Cellulitis (HP:0100658)2.67974713
48Chronic mucocutaneous candidiasis (HP:0002728)2.65840791
49Recurrent cutaneous fungal infections (HP:0011370)2.65840791
50Spontaneous hematomas (HP:0007420)2.63845550
51Gastrointestinal inflammation (HP:0004386)2.61391171
52Nasal polyposis (HP:0100582)2.58287017
53Urticaria (HP:0001025)2.58230638
54Pulmonary infiltrates (HP:0002113)2.58026034
55Abnormality of T cells (HP:0002843)2.56878618
56Panhypogammaglobulinemia (HP:0003139)2.54555071
57Keratoconjunctivitis sicca (HP:0001097)2.52612613
58Gingivitis (HP:0000230)2.52302756
59Inflammation of the large intestine (HP:0002037)2.49784907
60Agammaglobulinemia (HP:0004432)2.48671954
61Peritonitis (HP:0002586)2.47711661
62Dilatation of the ascending aorta (HP:0005111)2.47162732
63Granulocytopenia (HP:0001913)2.44907195
64Abnormality of the distal phalanges of the toes (HP:0010182)2.44676885
65Keratoconjunctivitis (HP:0001096)2.44162700
66Leukocytosis (HP:0001974)2.43341431
67Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42781515
68Right ventricular cardiomyopathy (HP:0011663)2.41074950
69Petechiae (HP:0000967)2.40324035
70Slow saccadic eye movements (HP:0000514)2.37460806
71Lymphopenia (HP:0001888)2.35965375
72Chest pain (HP:0100749)2.33817665
73Premature rupture of membranes (HP:0001788)2.33612987
74Vertebral compression fractures (HP:0002953)2.31848091
75Plantar hyperkeratosis (HP:0007556)2.31005318
76Colitis (HP:0002583)2.30098963
77Onycholysis (HP:0001806)2.30057817
78Gastrointestinal stroma tumor (HP:0100723)2.28468579
79Polycythemia (HP:0001901)2.27294334
80Fragile nails (HP:0001808)2.25894090
81Eczematoid dermatitis (HP:0000976)2.24626045
82Nail dystrophy (HP:0008404)2.24160099
83Prolonged bleeding time (HP:0003010)2.24113467
84Elevated erythrocyte sedimentation rate (HP:0003565)2.23993512
85Aortic dissection (HP:0002647)2.23986265
86Purpura (HP:0000979)2.21875330
87Systemic lupus erythematosus (HP:0002725)2.21700748
88Hemoptysis (HP:0002105)2.21266851
89Verrucae (HP:0200043)2.18689778
90Papilloma (HP:0012740)2.18689778
91J-shaped sella turcica (HP:0002680)2.18245817
92Xanthomatosis (HP:0000991)2.17805599
93Mitral valve prolapse (HP:0001634)2.17240649
94Myocardial infarction (HP:0001658)2.17055063
95Hematochezia (HP:0002573)2.16384434
96Sepsis (HP:0100806)2.16365185
97Joint swelling (HP:0001386)2.14716413
98Interstitial pulmonary disease (HP:0006530)2.14333614
99Abnormality of cells of the lymphoid lineage (HP:0012140)2.13361352
100Autoimmune hemolytic anemia (HP:0001890)2.13213196
101Eosinophilia (HP:0001880)2.12065129
102Radial bowing (HP:0002986)2.10240625
103IgG deficiency (HP:0004315)2.09831968
104Acute hepatic failure (HP:0006554)2.09506895
105Genu recurvatum (HP:0002816)2.09468107
106Episodic fever (HP:0001954)2.09043641
107Epistaxis (HP:0000421)2.07091792
108Abnormality of the Achilles tendon (HP:0005109)2.06755824
109Mesangial abnormality (HP:0001966)2.06156765
110Abnormality of glutamine family amino acid metabolism (HP:0010902)2.05987104
111Aneurysm (HP:0002617)2.04251065
112Increased serum ferritin (HP:0003281)2.02848551
113Anorexia (HP:0002039)2.02822696
114Abnormal hair laboratory examination (HP:0003328)2.02672408
115Abnormality of T cell physiology (HP:0011840)2.01952956
116Hydroxyprolinuria (HP:0003080)2.01464587
117Abnormality of proline metabolism (HP:0010907)2.01464587
118Shallow orbits (HP:0000586)2.01176411
119Achilles tendon contracture (HP:0001771)2.00256008
120Abnormality of eosinophils (HP:0001879)1.98731761
121Amyloidosis (HP:0011034)1.97384688
122Severe combined immunodeficiency (HP:0004430)1.96006461
123Metaphyseal cupping (HP:0003021)1.95201385
124Esophageal varix (HP:0002040)1.95131384
125Gingival bleeding (HP:0000225)1.94851271
126Woolly hair (HP:0002224)1.94730003
127Growth hormone excess (HP:0000845)1.94400475
128Gangrene (HP:0100758)1.93801931
129Recurrent bronchitis (HP:0002837)1.93262341
130Wrist flexion contracture (HP:0001239)1.89341384
131Osteomyelitis (HP:0002754)1.88591801
132Acne (HP:0001061)1.88578010
133Thin bony cortex (HP:0002753)1.86754381
134Palmoplantar hyperkeratosis (HP:0000972)1.85823374
135Prolonged neonatal jaundice (HP:0006579)1.85697251
136Joint stiffness (HP:0001387)1.84858965
137Chronic otitis media (HP:0000389)1.84306958
138Abnormality of nail color (HP:0100643)1.84220356
139Back pain (HP:0003418)1.82530552
140Bowing of the arm (HP:0006488)1.82041089
141Bowed forearm bones (HP:0003956)1.82041089
142Easy fatigability (HP:0003388)1.81904408
143Progressive neurologic deterioration (HP:0002344)1.81528294
144Urinary glycosaminoglycan excretion (HP:0003541)1.81193825
145Mucopolysacchariduria (HP:0008155)1.81193825
146Malnutrition (HP:0004395)1.80753577
147Spastic diplegia (HP:0001264)1.80474241
148Thrombocytosis (HP:0001894)1.79707032
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.79110566
150Osteolytic defects of the hand bones (HP:0009699)1.79110566
151Hypotrichosis (HP:0001006)1.77983152
152Camptodactyly of toe (HP:0001836)1.77747896
153Deep venous thrombosis (HP:0002625)1.77599407
154Autoimmune thrombocytopenia (HP:0001973)1.77582163
155Emphysema (HP:0002097)1.77491456
156Alopecia of scalp (HP:0002293)1.76430128
157Ulnar bowing (HP:0003031)1.75737457
158Blue sclerae (HP:0000592)1.73823981
159Ulnar deviation of the wrist (HP:0003049)1.73536252
160Polygenic inheritance (HP:0010982)1.72995211
161Ectopia lentis (HP:0001083)1.71428400
162Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69172662
163Flat acetabular roof (HP:0003180)1.67656005
164Abnormality of mucopolysaccharide metabolism (HP:0011020)1.67527028
165Abnormality of polysaccharide metabolism (HP:0011012)1.67527028
166Abnormality of glycosaminoglycan metabolism (HP:0004371)1.67527028
167Increased density of long bones (HP:0006392)1.67300385
168Long toe (HP:0010511)1.67064456
169Biconcave vertebral bodies (HP:0004586)1.65890577
170Palmar hyperkeratosis (HP:0010765)1.64772787
171Increased connective tissue (HP:0009025)1.63322212
172Fatigue (HP:0012378)1.62713124
173Trismus (HP:0000211)1.62470084
174Mitral stenosis (HP:0001718)1.62419742
175Chondrocalcinosis (HP:0000934)1.62396634
176Difficulty climbing stairs (HP:0003551)1.62023201
177Broad metatarsal (HP:0001783)1.60714472
178Abnormal cartilage morphology (HP:0002763)1.59908548
179Distal lower limb muscle weakness (HP:0009053)1.59621956
180Skin ulcer (HP:0200042)1.59532299
181Pustule (HP:0200039)1.59437654
182Elbow flexion contracture (HP:0002987)1.59037488
183Spinal muscular atrophy (HP:0007269)1.54957182
184Persistence of primary teeth (HP:0006335)1.54395859
185Stroke (HP:0001297)1.53777259

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.34848884
2ERN13.27773801
3EEF2K2.83162618
4PRPF4B2.77240199
5PKN22.73924641
6MAP3K102.68756541
7RIPK42.61019463
8MAPKAPK32.49599674
9EPHA22.47492914
10FGFR42.24543538
11TGFBR22.24155423
12MAP4K12.13035284
13LRRK22.08279807
14TNK22.00716930
15SIK31.99407310
16MAP3K31.94946951
17TXK1.86973197
18STK101.84097206
19FES1.83838761
20TYK21.83738572
21TBK11.81352818
22JAK31.78766428
23SCYL21.74007807
24PTK61.68614097
25RIPK11.63596076
26MAP3K131.62965397
27IRAK41.59674222
28TTN1.58107201
29SIK11.55814227
30ZAP701.52050952
31IRAK31.48431727
32RPS6KB21.43799577
33GRK61.43522252
34TGFBR11.41780648
35TESK11.34323012
36KDR1.31421784
37PAK41.30539223
38TAOK11.30433695
39NME21.27438767
40PRKD21.27073032
41RPS6KA41.26941799
42TAOK31.25679116
43FLT31.25027014
44SMG11.24899654
45MAP2K31.24705451
46MAP3K141.23361594
47BCKDK1.22388570
48TESK21.21487142
49SYK1.17708702
50DDR21.09172947
51PIM21.08574929
52CDC42BPA1.08243148
53KSR21.05571289
54EPHA31.05567839
55CHUK1.04330253
56MAP3K111.01571443
57MARK21.01441535
58PTK21.01333315
59IKBKB0.98254111
60MAP3K90.97867012
61LYN0.96180031
62PDGFRA0.94976230
63NEK20.93498165
64EPHB10.93297833
65MAP3K80.92883910
66JAK10.91033722
67MAPK150.89422987
68FGR0.87184926
69MATK0.85403867
70IKBKE0.84059297
71KIT0.83262079
72CDK40.81852121
73MAP3K60.79793045
74ITK0.77408258
75MAP2K20.76740409
76FGFR30.76456988
77PRKD30.75690235
78MTOR0.75227454
79CSK0.72664349
80ICK0.71835526
81MAPK70.70689904
82HIPK20.70509592
83CDK60.69658692
84STK380.68583931
85NLK0.68279056
86ARAF0.67817794
87MAPK120.67636559
88BTK0.67489789
89TSSK60.67156167
90PDK10.65667993
91JAK20.65480843
92PIM10.65461381
93BMX0.63220308
94GRK70.63198736
95PAK20.62662186
96MST1R0.62272013
97PDPK10.62064590
98RPS6KC10.61863453
99RPS6KL10.61863453
100PRKCQ0.61733302
101NEK10.61586475
102CSF1R0.61360705
103RPS6KA20.60984038
104CDK120.59939242
105BUB10.58334976
106DYRK1B0.58175594
107MAP3K20.57429260
108MUSK0.56919473
109MARK30.55703108
110LATS20.55156486
111PASK0.54053072
112CAMKK10.53749848
113HCK0.53502484
114RPS6KA60.52391073
115FER0.51957605
116MET0.51878158
117MAPK110.50909531
118MAP3K50.49938295
119MAP2K10.49535242
120ACVR1B0.48955795
121ALK0.48642992
122MAP3K10.48194368
123BLK0.47538244
124MAP3K70.47497357
125FGFR10.46933986
126MOS0.45618413
127PRKCI0.44699630
128RET0.44053261
129NTRK10.43899540
130TAOK20.41137306
131MAPKAPK20.40927576
132RAF10.40808565
133IRAK10.40362496
134SIK20.39754769
135FYN0.39733962
136MST40.39120855
137LCK0.37629318
138TEC0.37373571
139MAP2K60.36987224
140MAPK40.36198721
141PRKD10.33120619
142CAMKK20.33027343

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004602.48788162
2Graft-versus-host disease_Homo sapiens_hsa053322.39934890
3Allograft rejection_Homo sapiens_hsa053302.28932363
4Autoimmune thyroid disease_Homo sapiens_hsa053202.09289599
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.08085926
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.98669029
7Antigen processing and presentation_Homo sapiens_hsa046121.77954851
8Malaria_Homo sapiens_hsa051441.69947048
9Hematopoietic cell lineage_Homo sapiens_hsa046401.68480934
10Bladder cancer_Homo sapiens_hsa052191.66381089
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62843861
12Nitrogen metabolism_Homo sapiens_hsa009101.56079197
13Small cell lung cancer_Homo sapiens_hsa052221.53785435
14Type I diabetes mellitus_Homo sapiens_hsa049401.53254725
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50839215
16Shigellosis_Homo sapiens_hsa051311.48321709
17Toxoplasmosis_Homo sapiens_hsa051451.47636498
18Chronic myeloid leukemia_Homo sapiens_hsa052201.46081523
19Selenocompound metabolism_Homo sapiens_hsa004501.45882360
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44333796
21Osteoclast differentiation_Homo sapiens_hsa043801.38066956
22Leishmaniasis_Homo sapiens_hsa051401.37477230
23Acute myeloid leukemia_Homo sapiens_hsa052211.33961760
24p53 signaling pathway_Homo sapiens_hsa041151.29740937
25Chemokine signaling pathway_Homo sapiens_hsa040621.29604343
26Apoptosis_Homo sapiens_hsa042101.28939728
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28441833
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27134661
29Rheumatoid arthritis_Homo sapiens_hsa053231.27127748
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.26111790
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26084344
32Primary immunodeficiency_Homo sapiens_hsa053401.23574710
33Caffeine metabolism_Homo sapiens_hsa002321.23200643
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.20048915
35Staphylococcus aureus infection_Homo sapiens_hsa051501.19352509
36Other glycan degradation_Homo sapiens_hsa005111.17157472
37TNF signaling pathway_Homo sapiens_hsa046681.14181114
38Sulfur relay system_Homo sapiens_hsa041221.13397753
39Legionellosis_Homo sapiens_hsa051341.12621953
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.11509159
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10189436
42Measles_Homo sapiens_hsa051621.09819018
43One carbon pool by folate_Homo sapiens_hsa006701.06978723
44Salmonella infection_Homo sapiens_hsa051321.06843227
45VEGF signaling pathway_Homo sapiens_hsa043701.05039970
46Proteoglycans in cancer_Homo sapiens_hsa052051.04862688
47B cell receptor signaling pathway_Homo sapiens_hsa046621.03456618
48HTLV-I infection_Homo sapiens_hsa051661.02912770
49T cell receptor signaling pathway_Homo sapiens_hsa046601.01249047
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00710527
51Biosynthesis of amino acids_Homo sapiens_hsa012301.00077361
52Phagosome_Homo sapiens_hsa041450.99591921
53Adherens junction_Homo sapiens_hsa045200.98710523
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97742665
55Notch signaling pathway_Homo sapiens_hsa043300.96868922
56Asthma_Homo sapiens_hsa053100.96655959
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.95508595
58Amoebiasis_Homo sapiens_hsa051460.94897635
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94620579
60Pancreatic cancer_Homo sapiens_hsa052120.94570517
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94331604
62Endocytosis_Homo sapiens_hsa041440.92921054
63ECM-receptor interaction_Homo sapiens_hsa045120.92811355
64Insulin resistance_Homo sapiens_hsa049310.92035576
65Focal adhesion_Homo sapiens_hsa045100.91700781
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91251534
67Influenza A_Homo sapiens_hsa051640.89749701
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87389016
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.87206392
70mTOR signaling pathway_Homo sapiens_hsa041500.85788500
71Pentose phosphate pathway_Homo sapiens_hsa000300.85752605
72African trypanosomiasis_Homo sapiens_hsa051430.85621992
73Lysosome_Homo sapiens_hsa041420.84108388
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83962408
75Fatty acid degradation_Homo sapiens_hsa000710.83893767
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82941625
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.81367562
78Viral myocarditis_Homo sapiens_hsa054160.80069140
79Herpes simplex infection_Homo sapiens_hsa051680.79668410
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.79563574
81Hepatitis B_Homo sapiens_hsa051610.79298331
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78716611
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78697322
84Platelet activation_Homo sapiens_hsa046110.78026886
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77722458
86Arginine biosynthesis_Homo sapiens_hsa002200.77500279
87Viral carcinogenesis_Homo sapiens_hsa052030.76585827
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.75485304
89Prion diseases_Homo sapiens_hsa050200.74282574
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73734324
91Thyroid cancer_Homo sapiens_hsa052160.73147268
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72559603
93MicroRNAs in cancer_Homo sapiens_hsa052060.72509686
94Folate biosynthesis_Homo sapiens_hsa007900.72443446
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.71610742
96Complement and coagulation cascades_Homo sapiens_hsa046100.71289878
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71239585
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71078514
99Prolactin signaling pathway_Homo sapiens_hsa049170.70849050
100Hippo signaling pathway_Homo sapiens_hsa043900.70180339
101Epstein-Barr virus infection_Homo sapiens_hsa051690.68927799
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66753671
103Tryptophan metabolism_Homo sapiens_hsa003800.66558516
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.63869982
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.63812907
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63359334
107DNA replication_Homo sapiens_hsa030300.62842684
108TGF-beta signaling pathway_Homo sapiens_hsa043500.62362206
109PPAR signaling pathway_Homo sapiens_hsa033200.62217569
110Bile secretion_Homo sapiens_hsa049760.61946994
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.61754647
112HIF-1 signaling pathway_Homo sapiens_hsa040660.61534423
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.61404643
114Renal cell carcinoma_Homo sapiens_hsa052110.60916402
115Tuberculosis_Homo sapiens_hsa051520.60629983
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60529767
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60410009
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59709378
119Colorectal cancer_Homo sapiens_hsa052100.59009144
120Hepatitis C_Homo sapiens_hsa051600.58324176
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58275165
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58043001
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56683978
124Choline metabolism in cancer_Homo sapiens_hsa052310.55196490
125Carbon metabolism_Homo sapiens_hsa012000.55024935
126Non-small cell lung cancer_Homo sapiens_hsa052230.54926519
127Pertussis_Homo sapiens_hsa051330.54566713
128Base excision repair_Homo sapiens_hsa034100.54026437
129Endometrial cancer_Homo sapiens_hsa052130.52293670
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51059584
131Inositol phosphate metabolism_Homo sapiens_hsa005620.50420459
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49483552
133FoxO signaling pathway_Homo sapiens_hsa040680.49447409
134MAPK signaling pathway_Homo sapiens_hsa040100.47524438
135Dorso-ventral axis formation_Homo sapiens_hsa043200.45506477
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.43891149
137GnRH signaling pathway_Homo sapiens_hsa049120.41363412
138Fructose and mannose metabolism_Homo sapiens_hsa000510.37086068
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33572888
140Galactose metabolism_Homo sapiens_hsa000520.32894577

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