TBC1D10B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.81735372
2protein localization to endosome (GO:0036010)4.43845393
3axon ensheathment in central nervous system (GO:0032291)4.26662762
4central nervous system myelination (GO:0022010)4.26662762
5negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.17611080
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.80782545
7negative regulation of cell killing (GO:0031342)3.80782545
8cortical actin cytoskeleton organization (GO:0030866)3.78973646
9cytoskeletal anchoring at plasma membrane (GO:0007016)3.70804453
10regulation of early endosome to late endosome transport (GO:2000641)3.46531142
11mannose metabolic process (GO:0006013)3.45905275
12regulation of mammary gland epithelial cell proliferation (GO:0033599)3.29096617
13response to nerve growth factor (GO:1990089)3.26882585
14cellular response to nerve growth factor stimulus (GO:1990090)3.26882585
15regulation of ARF GTPase activity (GO:0032312)3.24293342
16cortical cytoskeleton organization (GO:0030865)3.19864907
17positive regulation of Cdc42 GTPase activity (GO:0043089)3.12054163
18synaptic vesicle maturation (GO:0016188)3.09984468
19myelin maintenance (GO:0043217)3.09051653
20activation of Rac GTPase activity (GO:0032863)3.08377427
21negative regulation of cell size (GO:0045792)3.02729583
22modulation by virus of host process (GO:0019054)3.02490634
23modulation by symbiont of host cellular process (GO:0044068)3.02454847
24establishment of mitochondrion localization (GO:0051654)3.01095559
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.00888021
26cell-cell junction maintenance (GO:0045217)2.99880800
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99609675
28nerve growth factor signaling pathway (GO:0038180)2.96493257
29regulation of leukocyte degranulation (GO:0043300)2.94999605
30axon ensheathment (GO:0008366)2.94714940
31ensheathment of neurons (GO:0007272)2.94714940
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.90593499
33positive regulation of protein dephosphorylation (GO:0035307)2.89017220
34regulation of chromatin binding (GO:0035561)2.86599730
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.86532146
36positive regulation by organism of defense response of other organism involved in symbiotic interact2.86532146
37modulation by symbiont of host immune response (GO:0052553)2.86532146
38positive regulation by symbiont of host defense response (GO:0052509)2.86532146
39modulation by symbiont of host defense response (GO:0052031)2.86532146
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.86532146
41myelination (GO:0042552)2.80407175
42regulation of NFAT protein import into nucleus (GO:0051532)2.79150987
43antigen processing and presentation of endogenous antigen (GO:0019883)2.78985249
44adherens junction assembly (GO:0034333)2.78398799
45L-amino acid import (GO:0043092)2.77506882
46cell-substrate adherens junction assembly (GO:0007045)2.72846764
47focal adhesion assembly (GO:0048041)2.72846764
48regulation of myeloid leukocyte mediated immunity (GO:0002886)2.72008807
49semaphorin-plexin signaling pathway (GO:0071526)2.71042926
50NIK/NF-kappaB signaling (GO:0038061)2.69735879
51lipopolysaccharide-mediated signaling pathway (GO:0031663)2.68069915
52negative regulation of fatty acid transport (GO:2000192)2.67736537
53apoptotic process involved in morphogenesis (GO:0060561)2.66724177
54regulation of T-helper 2 cell differentiation (GO:0045628)2.65899481
55negative regulation of adherens junction organization (GO:1903392)2.65898182
56negative regulation of focal adhesion assembly (GO:0051895)2.65898182
57negative regulation of cell junction assembly (GO:1901889)2.65898182
58positive regulation of protein deacetylation (GO:0090312)2.65287154
59sodium ion export (GO:0071436)2.64916456
60stress fiber assembly (GO:0043149)2.64301351
61regulation of regulated secretory pathway (GO:1903305)2.63916787
62regulation of defense response to virus by virus (GO:0050690)2.61861713
63regulation of mast cell degranulation (GO:0043304)2.61750114
64thymic T cell selection (GO:0045061)2.61706976
65positive regulation of Rap GTPase activity (GO:0032854)2.61095539
66activation of MAPKKK activity (GO:0000185)2.60880185
67negative regulation of GTP catabolic process (GO:0033125)2.55164928
68negative regulation of GTPase activity (GO:0034260)2.55164928
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.54595195
70regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53096090
71neutrophil activation involved in immune response (GO:0002283)2.52694864
72positive thymic T cell selection (GO:0045059)2.51684652
73peptidyl-tyrosine autophosphorylation (GO:0038083)2.50995540
74positive regulation of gamma-delta T cell activation (GO:0046645)2.50972865
753-UTR-mediated mRNA stabilization (GO:0070935)2.50930776
76regulation of interferon-beta biosynthetic process (GO:0045357)2.50167059
77response to muramyl dipeptide (GO:0032495)2.48470769
78cellular response to virus (GO:0098586)2.48286032
79positive regulation of blood vessel endothelial cell migration (GO:0043536)2.46669837
80vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.46244776
81regulation of apoptotic process involved in morphogenesis (GO:1902337)2.45761191
82amino acid import (GO:0043090)2.43815006
83endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.43641253
84chromatin assembly (GO:0031497)2.41575061
85positive regulation of CREB transcription factor activity (GO:0032793)2.41248750
86regulation of glucose import in response to insulin stimulus (GO:2001273)2.40824972
87germinal center formation (GO:0002467)2.39551479
88layer formation in cerebral cortex (GO:0021819)2.39365109
89macrophage activation involved in immune response (GO:0002281)2.37821727
90Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.37633817
91regulation of Rap GTPase activity (GO:0032317)2.37604013
92barbed-end actin filament capping (GO:0051016)2.37199829
93positive regulation of receptor recycling (GO:0001921)2.37130726
94Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.37128914
95immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.37128914
96Fc-gamma receptor signaling pathway (GO:0038094)2.37128914
97negative regulation of interleukin-12 production (GO:0032695)2.37035812
98regulation of integrin activation (GO:0033623)2.36991553
99regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.36835561
100cytoplasmic mRNA processing body assembly (GO:0033962)2.36202334
101negative regulation of myotube differentiation (GO:0010832)2.35445793
102spindle assembly involved in mitosis (GO:0090307)2.34823068
103regulation of posttranscriptional gene silencing (GO:0060147)2.34029447
104regulation of gene silencing by miRNA (GO:0060964)2.34029447
105regulation of gene silencing by RNA (GO:0060966)2.34029447
106positive regulation of histone deacetylation (GO:0031065)2.32508764
107negative regulation of toll-like receptor signaling pathway (GO:0034122)2.31537987
108heterochromatin organization (GO:0070828)2.31426228
109clathrin coat assembly (GO:0048268)2.30997618
110mitochondrion transport along microtubule (GO:0047497)2.30633875
111establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.30633875
112intracellular estrogen receptor signaling pathway (GO:0030520)2.30512110
113positive regulation of myotube differentiation (GO:0010831)2.30211266
114activated T cell proliferation (GO:0050798)2.29867800
115leukocyte aggregation (GO:0070486)2.29409624
116regulation of extracellular matrix disassembly (GO:0010715)2.29323609
117pre-miRNA processing (GO:0031054)2.29273804
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.29148707
119modulation by virus of host morphology or physiology (GO:0019048)2.28794652
120negative regulation of viral release from host cell (GO:1902187)2.28139485
121detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.25721628
122detection of temperature stimulus involved in sensory perception (GO:0050961)2.25721628
123adaptation of signaling pathway (GO:0023058)2.25684646
124regulation of fatty acid beta-oxidation (GO:0031998)2.25640670
125regulation of protein heterodimerization activity (GO:0043497)2.25115775
126negative regulation of microtubule polymerization (GO:0031115)2.24993040
127detection of bacterium (GO:0016045)2.24838105
128response to laminar fluid shear stress (GO:0034616)2.24616852
129response to lipoprotein particle (GO:0055094)2.24295455
130detection of other organism (GO:0098543)2.23950693
131antigen processing and presentation via MHC class Ib (GO:0002475)2.23333272
132positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.22634270
133histone H4 deacetylation (GO:0070933)2.21610834
134negative regulation of nucleotide catabolic process (GO:0030812)2.21440552
135glucocorticoid receptor signaling pathway (GO:0042921)2.21168538
136regulation of mast cell activation involved in immune response (GO:0033006)2.20698388
137negative regulation of granulocyte differentiation (GO:0030853)2.20598689
138G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.19331539
139maternal placenta development (GO:0001893)2.18623878
140negative regulation of macroautophagy (GO:0016242)2.17320011
141regulation of histone H3-K27 methylation (GO:0061085)2.16622591
142regulation of gamma-delta T cell activation (GO:0046643)2.15970087
143immunoglobulin mediated immune response (GO:0016064)2.15163455
144response to host (GO:0075136)2.14632886
145response to host defenses (GO:0052200)2.14632886
146response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.14632886
147respiratory burst (GO:0045730)2.14593412
148positive regulation of gene expression, epigenetic (GO:0045815)2.14496751
149cell-substrate junction assembly (GO:0007044)2.14212896
150regulation of histone deacetylation (GO:0031063)2.14158160
151regulation of ARF protein signal transduction (GO:0032012)2.13858073
152granulocyte activation (GO:0036230)2.13536314
153leukocyte migration involved in inflammatory response (GO:0002523)2.11579808
154positive regulation of SMAD protein import into nucleus (GO:0060391)2.10639434
155B cell receptor signaling pathway (GO:0050853)2.10258789
156response to peptidoglycan (GO:0032494)2.08042860
157creatine metabolic process (GO:0006600)2.07726799
158myeloid cell activation involved in immune response (GO:0002275)2.07159746
159signal complex assembly (GO:0007172)2.06735175
160adenosine receptor signaling pathway (GO:0001973)2.06662827
161negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.06624144
162positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.06420844
163cellular potassium ion homeostasis (GO:0030007)2.06174183
164peptidyl-threonine phosphorylation (GO:0018107)2.05339934
165labyrinthine layer development (GO:0060711)2.03173536
166negative regulation of interleukin-8 production (GO:0032717)2.01853782
167establishment of endothelial barrier (GO:0061028)2.00598808
168positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling1.99619063
169activation of JUN kinase activity (GO:0007257)1.99327767
170cell migration in hindbrain (GO:0021535)1.99273601

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.05558219
2E2F7_22180533_ChIP-Seq_HELA_Human3.00614529
3MYC_22102868_ChIP-Seq_BL_Human2.87007391
4KDM2B_26808549_Chip-Seq_DND41_Human2.78820145
5* VDR_21846776_ChIP-Seq_THP-1_Human2.75819012
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.70778243
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59426286
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.57069006
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.47167169
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.47167169
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.47167169
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.41472870
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.40458188
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.32177599
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.26600886
16TCF7_22412390_ChIP-Seq_EML_Mouse2.19458850
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.19297179
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19131135
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.16618061
20* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.11701746
21ZFP281_18757296_ChIP-ChIP_E14_Mouse2.10804870
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02301433
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01275310
24KDM2B_26808549_Chip-Seq_K562_Human1.97051421
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96260271
26ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.94736041
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.89008950
28KDM2B_26808549_Chip-Seq_JURKAT_Human1.88394033
29ZFP281_27345836_Chip-Seq_ESCs_Mouse1.86857940
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.80722036
31SPI1_23127762_ChIP-Seq_K562_Human1.80578777
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78366880
33LXR_22292898_ChIP-Seq_THP-1_Human1.75221157
34MAF_26560356_Chip-Seq_TH1_Human1.74374115
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73124044
36P300_27058665_Chip-Seq_ZR-75-30cells_Human1.71139980
37* VDR_24763502_ChIP-Seq_THP-1_Human1.69951471
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.69504714
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68573965
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67894389
41NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.67263835
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65590020
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.61103599
44SMC4_20622854_ChIP-Seq_HELA_Human1.57657866
45* RACK7_27058665_Chip-Seq_MCF-7_Human1.55941581
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.55602885
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55528125
48ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54421645
49* UTX_26944678_Chip-Seq_JUKART_Human1.54101127
50* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.53488912
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.52817285
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52675204
53* RARB_27405468_Chip-Seq_BRAIN_Mouse1.51908648
54NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51608177
55GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51041124
56SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50092637
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48672943
58* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48147923
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47873006
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46671482
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45760146
62ELF1_20517297_ChIP-Seq_JURKAT_Human1.45621035
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42655959
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41925378
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41125964
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40458309
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39286996
68NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.39174614
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36394598
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35752014
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33894254
72* RUNX1_22412390_ChIP-Seq_EML_Mouse1.33345878
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31867013
74MAF_26560356_Chip-Seq_TH2_Human1.30926184
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30583839
76* BCL6_27268052_Chip-Seq_Bcells_Human1.29578084
77GATA1_19941826_ChIP-Seq_K562_Human1.28639342
78TP53_22127205_ChIP-Seq_IMR90_Human1.28290389
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27383387
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26480187
81SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25084970
82* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24636105
83RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23728810
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22007572
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21588075
86CTCF_27219007_Chip-Seq_Bcells_Human1.20519268
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18126083
88* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17669597
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16702211
90NCOR1_26117541_ChIP-Seq_K562_Human1.16639610
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15425136
92MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14731983
93TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14261530
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14231748
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14184417
96* CREB1_26743006_Chip-Seq_LNCaP_Human1.13584018
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13181055
98GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12789732
99RUNX_20019798_ChIP-Seq_JUKART_Human1.11771175
100* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.09944598
101ATF3_27146783_Chip-Seq_COLON_Human1.07861556
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06493249
103* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06077253
104PHF8_20622854_ChIP-Seq_HELA_Human1.05981259
105TP63_22573176_ChIP-Seq_HFKS_Human1.05905940
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05893710
107RUNX1_27514584_Chip-Seq_MCF-7_Human1.04973514
108* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04715310
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03554912
110MYB_26560356_Chip-Seq_TH2_Human1.02840042
111CTCF_26484167_Chip-Seq_Bcells_Mouse1.02762553
112SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02585700
113E2F1_20622854_ChIP-Seq_HELA_Human1.02352322
114* SA1_27219007_Chip-Seq_Bcells_Human1.01977710
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01199825
116DROSHA_22980978_ChIP-Seq_HELA_Human1.00991391
117* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00899524
118FOXO3_23340844_ChIP-Seq_DLD1_Human1.00204606
119P68_20966046_ChIP-Seq_HELA_Human1.00189001
120SA1_27219007_Chip-Seq_ERYTHROID_Human0.99988979
121* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99520962
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98473699
123* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98125997
124TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97993494
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97352972
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.97305819
127FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96875393
128ETS1_21867929_ChIP-Seq_TH2_Mouse0.96328313
129IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95751425
130CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95518164
131GATA1_19941827_ChIP-Seq_MEL_Mouse0.95435854
132OCT4_19829295_ChIP-Seq_ESCs_Human0.95345709
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95090783
134DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94623330
135* BCOR_27268052_Chip-Seq_Bcells_Human0.93543316
136SCL_19346495_ChIP-Seq_HPC-7_Human0.93513550
137KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93345416
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93308995
139POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93245676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.99714169
2MP0004859_abnormal_synaptic_plasticity2.86902551
3MP0005451_abnormal_body_composition2.78369973
4MP0000920_abnormal_myelination2.57490504
5MP0004510_myositis2.53528151
6MP0005076_abnormal_cell_differentiation2.24115184
7MP0009840_abnormal_foam_cell2.22266335
8MP0009278_abnormal_bone_marrow2.16018299
9MP0004858_abnormal_nervous_system2.14081238
10MP0010352_gastrointestinal_tract_polyps2.08625709
11MP0003172_abnormal_lysosome_physiology2.01463570
12MP0005058_abnormal_lysosome_morphology2.00330271
13MP0004185_abnormal_adipocyte_glucose1.98283688
14MP0005409_darkened_coat_color1.97928546
15MP0003950_abnormal_plasma_membrane1.92356707
16MP0000678_abnormal_parathyroid_gland1.89064475
17MP0003705_abnormal_hypodermis_morpholog1.88386828
18MP0004270_analgesia1.80627483
19MP0003329_amyloid_beta_deposits1.78091790
20MP0003300_gastrointestinal_ulcer1.75054471
21MP0002249_abnormal_larynx_morphology1.71914992
22MP0006082_CNS_inflammation1.70814402
23MP0005623_abnormal_meninges_morphology1.68033779
24MP0003566_abnormal_cell_adhesion1.65372387
25MP0001849_ear_inflammation1.65260448
26MP0003191_abnormal_cellular_cholesterol1.65138064
27MP0001348_abnormal_lacrimal_gland1.63739052
28MP0003448_altered_tumor_morphology1.62697587
29MP0003436_decreased_susceptibility_to1.60359663
30MP0003634_abnormal_glial_cell1.53128521
31MP0003763_abnormal_thymus_physiology1.51048965
32MP0003690_abnormal_glial_cell1.49960414
33MP0003279_aneurysm1.48248516
34MP0010307_abnormal_tumor_latency1.47873480
35MP0000733_abnormal_muscle_development1.44991419
36MP0005000_abnormal_immune_tolerance1.43059632
37MP0000604_amyloidosis1.42146457
38MP0003091_abnormal_cell_migration1.40584691
39MP0002998_abnormal_bone_remodeling1.36638583
40MP0003075_altered_response_to1.33431889
41MP0003183_abnormal_peptide_metabolism1.30650710
42MP0005666_abnormal_adipose_tissue1.30505134
43MP0004381_abnormal_hair_follicle1.30184656
44MP0002064_seizures1.28934769
45MP0005167_abnormal_blood-brain_barrier1.27303325
46MP0000685_abnormal_immune_system1.26497711
47MP0001790_abnormal_immune_system1.25914946
48MP0005387_immune_system_phenotype1.25914946
49MP0004885_abnormal_endolymph1.24716266
50MP0001873_stomach_inflammation1.23010778
51MP0003635_abnormal_synaptic_transmissio1.21849880
52MP0010234_abnormal_vibrissa_follicle1.21583570
53MP0002452_abnormal_antigen_presenting1.20831440
54MP0005310_abnormal_salivary_gland1.17179896
55MP0003453_abnormal_keratinocyte_physiol1.17107262
56MP0002419_abnormal_innate_immunity1.16224439
57MP0001800_abnormal_humoral_immune1.15739230
58MP0002089_abnormal_postnatal_growth/wei1.14879607
59MP0003879_abnormal_hair_cell1.14531605
60MP0002877_abnormal_melanocyte_morpholog1.13054448
61MP0002420_abnormal_adaptive_immunity1.12911101
62MP0001819_abnormal_immune_cell1.12488528
63MP0001958_emphysema1.11237327
64MP0004233_abnormal_muscle_weight1.10934803
65MP0002723_abnormal_immune_serum1.10252785
66MP0000569_abnormal_digit_pigmentation1.10030839
67MP0004947_skin_inflammation1.06159325
68MP0001730_embryonic_growth_arrest1.06139814
69MP0003123_paternal_imprinting1.05174768
70MP0009333_abnormal_splenocyte_physiolog1.05112659
71MP0000681_abnormal_thyroid_gland1.04775642
72MP0001851_eye_inflammation1.04670298
73MP0005025_abnormal_response_to1.04247995
74MP0000747_muscle_weakness1.03417078
75MP0002398_abnormal_bone_marrow1.02946662
76MP0005390_skeleton_phenotype1.02217546
77MP0004808_abnormal_hematopoietic_stem1.02215637
78MP0004130_abnormal_muscle_cell0.98244370
79MP0008770_decreased_survivor_rate0.97912759
80MP0000767_abnormal_smooth_muscle0.97090977
81MP0002396_abnormal_hematopoietic_system0.96599182
82MP0002405_respiratory_system_inflammati0.95041245
83MP0010155_abnormal_intestine_physiology0.94615686
84MP0000955_abnormal_spinal_cord0.94123361
85MP0000350_abnormal_cell_proliferation0.93034858
86MP0004811_abnormal_neuron_physiology0.92548062
87MP0003866_abnormal_defecation0.92167558
88MP0003045_fibrosis0.91987585
89MP0000716_abnormal_immune_system0.91985944
90MP0003632_abnormal_nervous_system0.90021191
91MP0001970_abnormal_pain_threshold0.89564121
92MP0005671_abnormal_response_to0.89218084
93MP0008961_abnormal_basal_metabolism0.87846632
94MP0002733_abnormal_thermal_nociception0.86928635
95MP0000003_abnormal_adipose_tissue0.86866488
96MP0009046_muscle_twitch0.86667044
97MP0003633_abnormal_nervous_system0.86307923
98MP0008874_decreased_physiological_sensi0.86063698
99MP0003111_abnormal_nucleus_morphology0.85722666
100MP0010678_abnormal_skin_adnexa0.84464073
101MP0002063_abnormal_learning/memory/cond0.83375726
102MP0005464_abnormal_platelet_physiology0.82575889
103MP0009785_altered_susceptibility_to0.80964417
104MP0005670_abnormal_white_adipose0.80517497
105MP0003828_pulmonary_edema0.80500137
106MP0002653_abnormal_ependyma_morphology0.78587489
107MP0002722_abnormal_immune_system0.78034165
108MP0001486_abnormal_startle_reflex0.77758761
109MP0008569_lethality_at_weaning0.77355992
110MP0002429_abnormal_blood_cell0.77314766
111MP0003631_nervous_system_phenotype0.76536375
112MP0002933_joint_inflammation0.76416755
113MP0002148_abnormal_hypersensitivity_rea0.75700336
114MP0005375_adipose_tissue_phenotype0.75639172
115MP0008260_abnormal_autophagy0.75615157
116MP0002796_impaired_skin_barrier0.75361275
117MP0009931_abnormal_skin_appearance0.75229618
118MP0005397_hematopoietic_system_phenotyp0.75193493
119MP0001545_abnormal_hematopoietic_system0.75193493
120MP0000015_abnormal_ear_pigmentation0.75064953
121MP0001533_abnormal_skeleton_physiology0.74600668
122MP0001845_abnormal_inflammatory_respons0.74246055
123MP0005621_abnormal_cell_physiology0.74228115
124MP0000703_abnormal_thymus_morphology0.74137816
125MP0000689_abnormal_spleen_morphology0.73823899
126MP0000858_altered_metastatic_potential0.73798979
127MP0003724_increased_susceptibility_to0.73650521
128MP0005166_decreased_susceptibility_to0.73487169
129MP0005023_abnormal_wound_healing0.73486004
130MP0000759_abnormal_skeletal_muscle0.72001702
131MP0001835_abnormal_antigen_presentation0.71657216
132MP0001346_abnormal_lacrimal_gland0.70527650
133MP0002084_abnormal_developmental_patter0.70089564
134MP0004197_abnormal_fetal_growth/weight/0.70076636
135MP0002272_abnormal_nervous_system0.70057393
136MP0002086_abnormal_extraembryonic_tissu0.68479770
137MP0000778_abnormal_nervous_system0.67589274
138MP0000490_abnormal_crypts_of0.67034885
139MP0008438_abnormal_cutaneous_collagen0.66089162

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)3.70078923
2Supranuclear gaze palsy (HP:0000605)3.46074362
3Cerebral inclusion bodies (HP:0100314)3.29491257
4Neurofibrillary tangles (HP:0002185)3.19441076
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.83275716
6Degeneration of the lateral corticospinal tracts (HP:0002314)2.83275716
7Increased cerebral lipofuscin (HP:0011813)2.81007547
8Termporal pattern (HP:0011008)2.79506428
9Insidious onset (HP:0003587)2.79506428
10Apathy (HP:0000741)2.70209811
11Broad face (HP:0000283)2.66416884
12Cellulitis (HP:0100658)2.65798993
13Recurrent abscess formation (HP:0002722)2.65620933
14Eczematoid dermatitis (HP:0000976)2.64732093
15Abnormality of the corticospinal tract (HP:0002492)2.63661800
16Abnormality of macrophages (HP:0004311)2.53433415
17Achilles tendon contracture (HP:0001771)2.52418414
18Distal upper limb amyotrophy (HP:0007149)2.52359449
19Upper limb amyotrophy (HP:0009129)2.52359449
20Diminished motivation (HP:0000745)2.50596047
21Peripheral hypomyelination (HP:0007182)2.50050776
22Axonal loss (HP:0003447)2.48327380
23Difficulty running (HP:0009046)2.44031780
24Neuronal loss in central nervous system (HP:0002529)2.40303372
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.38498773
26Protrusio acetabuli (HP:0003179)2.37485686
27Myokymia (HP:0002411)2.36248078
28Disproportionate tall stature (HP:0001519)2.33149224
29Dysostosis multiplex (HP:0000943)2.31105189
30Long palpebral fissure (HP:0000637)2.30570556
31Hypercortisolism (HP:0001578)2.30186668
32Thin bony cortex (HP:0002753)2.27443504
33Hyperacusis (HP:0010780)2.27068657
34Ependymoma (HP:0002888)2.26448178
35Stridor (HP:0010307)2.23298317
36Rapidly progressive (HP:0003678)2.22801364
37Onion bulb formation (HP:0003383)2.21355900
38Disinhibition (HP:0000734)2.21058724
39Insomnia (HP:0100785)2.17828919
40Abnormality of binocular vision (HP:0011514)2.15858600
41Diplopia (HP:0000651)2.15858600
42Recurrent bacterial skin infections (HP:0005406)2.14431590
43Increased connective tissue (HP:0009025)2.13933662
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.11566672
45Ulnar bowing (HP:0003031)2.11385379
46Cerebral aneurysm (HP:0004944)2.08542145
47Emphysema (HP:0002097)2.07082259
48Abnormality of the astrocytes (HP:0100707)2.06344951
49Astrocytoma (HP:0009592)2.06344951
50Gingivitis (HP:0000230)2.03549527
51Segmental peripheral demyelination/remyelination (HP:0003481)2.02964594
52Abnormality of the thoracic spine (HP:0100711)2.02931975
53Increased variability in muscle fiber diameter (HP:0003557)2.02695251
54Hemorrhage of the eye (HP:0011885)2.02474544
55Patellar dislocation (HP:0002999)2.00250013
56Abnormality of the fingertips (HP:0001211)2.00182898
57Hyperparathyroidism (HP:0000843)2.00042151
58Recurrent viral infections (HP:0004429)1.99601966
59Recurrent fungal infections (HP:0002841)1.97941711
60Spastic gait (HP:0002064)1.97056967
61Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96925023
62Broad distal phalanx of finger (HP:0009836)1.96300615
63Loss of speech (HP:0002371)1.95866782
64Genu recurvatum (HP:0002816)1.95364334
65Vertebral compression fractures (HP:0002953)1.94963166
66Abnormality of the Achilles tendon (HP:0005109)1.94557871
67Fragile skin (HP:0001030)1.94418808
68Easy fatigability (HP:0003388)1.94417598
69Amyotrophic lateral sclerosis (HP:0007354)1.93314605
70Hypertensive crisis (HP:0100735)1.93181709
71Ankle clonus (HP:0011448)1.92459673
72Distal lower limb amyotrophy (HP:0008944)1.92364426
73Mitral regurgitation (HP:0001653)1.92298499
74Hand muscle atrophy (HP:0009130)1.91931127
75Spinal rigidity (HP:0003306)1.91393488
76Mutism (HP:0002300)1.91291799
77Stomatitis (HP:0010280)1.90072415
78Abnormality of polysaccharide metabolism (HP:0011012)1.89202095
79Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89202095
80Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89202095
81Truncus arteriosus (HP:0001660)1.88932915
82Lower limb amyotrophy (HP:0007210)1.88655442
83Cerebral hypomyelination (HP:0006808)1.87992127
84Urinary urgency (HP:0000012)1.87878224
85Chronic obstructive pulmonary disease (HP:0006510)1.87240839
86Obstructive lung disease (HP:0006536)1.87240839
87Centrally nucleated skeletal muscle fibers (HP:0003687)1.86629243
88J-shaped sella turcica (HP:0002680)1.86015583
89Polygenic inheritance (HP:0010982)1.84840562
90Distal lower limb muscle weakness (HP:0009053)1.84384726
91Frequent falls (HP:0002359)1.83993667
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83253795
93Gastrointestinal inflammation (HP:0004386)1.83208204
94Myositis (HP:0100614)1.82725741
95Large earlobe (HP:0009748)1.82217009
96Annular pancreas (HP:0001734)1.82017016
97Pointed chin (HP:0000307)1.81889382
98Gastrointestinal stroma tumor (HP:0100723)1.81694555
99Dysmetric saccades (HP:0000641)1.81469413
100Dysmetria (HP:0001310)1.81262493
101Agnosia (HP:0010524)1.80721645
102Macroorchidism (HP:0000053)1.80451633
103Gastrointestinal infarctions (HP:0005244)1.80320268
104Abnormality of the salivary glands (HP:0010286)1.80123921
105Visual hallucinations (HP:0002367)1.79020711
106Sensory axonal neuropathy (HP:0003390)1.77771938
107Metaphyseal cupping (HP:0003021)1.76171383
108Deep palmar crease (HP:0006191)1.75077301
109Persistence of primary teeth (HP:0006335)1.74866066
110Abnormality of skeletal muscle fiber size (HP:0012084)1.74358377
111Mucopolysacchariduria (HP:0008155)1.74300055
112Urinary glycosaminoglycan excretion (HP:0003541)1.74300055
113Aneurysm (HP:0002617)1.73685145
114Orchitis (HP:0100796)1.73230971
115Flat acetabular roof (HP:0003180)1.72772915
116Hyperthyroidism (HP:0000836)1.72661268
117Blue sclerae (HP:0000592)1.72243247
118Overriding aorta (HP:0002623)1.72150347
119Premature rupture of membranes (HP:0001788)1.70942437
120Bladder diverticulum (HP:0000015)1.69822607
121Abnormality of the distal phalanx of the thumb (HP:0009617)1.69161341
122Abnormal large intestine physiology (HP:0012700)1.67945280
123Hemiplegia (HP:0002301)1.67831424
124Urinary bladder sphincter dysfunction (HP:0002839)1.67448489
125Resting tremor (HP:0002322)1.67403270
126Myopathic facies (HP:0002058)1.67036494
127Bowel incontinence (HP:0002607)1.67035925
128Abnormality of the phalanges of the hallux (HP:0010057)1.66884728
129Slow saccadic eye movements (HP:0000514)1.65514741
130Shallow orbits (HP:0000586)1.64432591
131Abnormality of oral frenula (HP:0000190)1.63796291
132Colitis (HP:0002583)1.62752868
133Ankyloglossia (HP:0010296)1.62612600
134Spondylolisthesis (HP:0003302)1.62424799
135Dislocated radial head (HP:0003083)1.62016368
136Thoracic kyphosis (HP:0002942)1.61894093
137Abnormality of the radial head (HP:0003995)1.61309415
138Esophageal atresia (HP:0002032)1.61024617
139Intention tremor (HP:0002080)1.60742684
140Inappropriate behavior (HP:0000719)1.60666004
141Abnormality of liposaccharide metabolism (HP:0010968)1.60332898
142Abnormality of glycosphingolipid metabolism (HP:0004343)1.60332898
143Abnormality of glycolipid metabolism (HP:0010969)1.60332898
144Personality changes (HP:0000751)1.59540456
145Vertebral arch anomaly (HP:0008438)1.58835203
146Clumsiness (HP:0002312)1.57769466
147Increased IgE level (HP:0003212)1.57741625
148Mediastinal lymphadenopathy (HP:0100721)1.56868665
149Chronic otitis media (HP:0000389)1.56694356
150Papilledema (HP:0001085)1.55442290
151Foot dorsiflexor weakness (HP:0009027)1.54960362
152Spastic tetraparesis (HP:0001285)1.54260565
153Scapular winging (HP:0003691)1.53884528
154Round ear (HP:0100830)1.53249106
155Peritonitis (HP:0002586)1.51229153
156Abnormality of the periventricular white matter (HP:0002518)1.50979820
157Difficulty climbing stairs (HP:0003551)1.49532175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.40520567
2EPHB13.14956458
3PRPF4B3.10864272
4SMG13.03320134
5ERN13.01828972
6MAP3K92.86366847
7SIK12.82090802
8EEF2K2.69645041
9KSR22.58889162
10IRAK32.50898283
11MAP3K102.43945128
12CDK122.41377387
13ALK2.15498457
14RIPK42.09651839
15FGR2.06880796
16ICK1.98652584
17BMX1.90546821
18MAP2K31.89274427
19PAK61.86247016
20MAP3K111.81411439
21TYRO31.69268844
22MAP4K11.66139904
23NTRK11.65636051
24PKN21.62524027
25STK101.59551008
26GRK61.58853427
27SIK21.52913892
28CLK11.51978567
29BLK1.44753764
30TESK21.41225355
31FES1.36949014
32IRAK41.33793367
33CDC42BPA1.29603468
34PRKD31.28840062
35TTN1.27000207
36TAOK21.26026799
37NME21.16706714
38LRRK21.16484674
39TNK21.10716323
40PNCK1.10254942
41RPS6KA21.08297390
42FGFR41.08083449
43HCK1.07625819
44TAOK11.07344241
45PKN11.07053039
46CSK1.06974891
47MAP3K131.05036815
48UHMK11.03674789
49CAMK1D1.03643814
50MAP3K31.00573669
51PAK40.98216832
52RET0.95982661
53MAP3K80.93138396
54DAPK30.93098564
55STK390.91617005
56DMPK0.91320563
57BRAF0.90391705
58MET0.90108929
59ZAP700.89961738
60MOS0.89299890
61CSF1R0.89240169
62RIPK10.88852307
63ARAF0.87880207
64IRAK20.86521191
65MARK20.85898125
66DAPK20.85543438
67STK110.85154497
68GRK50.84194597
69PDPK10.83801506
70RPS6KC10.83751860
71RPS6KL10.83751860
72ROCK20.83402543
73LIMK10.80840550
74MATK0.79951438
75CDK140.78877129
76MAPK120.77832518
77SCYL20.77757441
78CDK150.77350738
79NEK20.75814952
80MAPK110.75397770
81PDGFRB0.74267202
82PAK10.73561333
83PDK10.72727388
84PTK60.71628994
85RPS6KA60.70844248
86PRKCH0.70008436
87CDK11A0.69661663
88RAF10.69559976
89PDGFRA0.68725900
90STK380.67398331
91STK40.66992520
92MAP3K140.66156223
93PRKD20.66081170
94TESK10.65381864
95CDK180.64769123
96LCK0.63267300
97CDK50.63011915
98CAMKK10.62179958
99TBK10.61262932
100OXSR10.61091988
101EPHA20.60990621
102FYN0.60226214
103DDR20.59642253
104MAP3K70.58888791
105PRKD10.57854430
106WNK10.57573686
107TRPM70.56897421
108MAPKAPK50.56363215
109PAK20.56112779
110EGFR0.55294061
111CDK190.54606735
112SIK30.52834166
113KSR10.52226387
114MINK10.52124808
115CSNK1D0.51249095
116MAP3K60.50881884
117MAP3K10.50380974
118JAK30.50351655
119BTK0.50298146
120HIPK20.48922414
121ILK0.48024292
122* MTOR0.47907851
123SYK0.47519975
124MAP2K20.46842292
125CDK40.46353649
126TYK20.44966933
127CAMK1G0.44378706
128MAP3K20.43645707
129RPS6KA10.41148874
130JAK20.40850250
131CAMK40.40796721
132PTK20.40510406
133MAPK40.40136829
134IKBKB0.39432467
135CAMK2B0.38855597
136KIT0.38560045
137LATS20.38476912
138PRKG20.38457632
139CDK70.37820273
140LMTK20.35698114
141CHUK0.35633938
142SGK30.34326827
143MAPKAPK20.30536760
144MAP2K60.29871273
145CAMK10.29267388

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.14168053
2Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.12120434
3Other glycan degradation_Homo sapiens_hsa005111.97426188
4B cell receptor signaling pathway_Homo sapiens_hsa046621.73061765
5Renal cell carcinoma_Homo sapiens_hsa052111.71283883
6VEGF signaling pathway_Homo sapiens_hsa043701.56947732
7Leishmaniasis_Homo sapiens_hsa051401.49995954
8Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49643101
9Osteoclast differentiation_Homo sapiens_hsa043801.42990108
10Chronic myeloid leukemia_Homo sapiens_hsa052201.40591328
11Dorso-ventral axis formation_Homo sapiens_hsa043201.39490928
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.37213544
13Shigellosis_Homo sapiens_hsa051311.33870198
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32384749
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32213181
16Glioma_Homo sapiens_hsa052141.31962987
17Chemokine signaling pathway_Homo sapiens_hsa040621.31421860
18Neurotrophin signaling pathway_Homo sapiens_hsa047221.31372094
19Non-small cell lung cancer_Homo sapiens_hsa052231.30784830
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.29060986
21Sphingolipid signaling pathway_Homo sapiens_hsa040711.26972353
22Endocytosis_Homo sapiens_hsa041441.23895516
23Salmonella infection_Homo sapiens_hsa051321.22849197
24Regulation of actin cytoskeleton_Homo sapiens_hsa048101.21054925
25Prion diseases_Homo sapiens_hsa050201.18657331
26Tuberculosis_Homo sapiens_hsa051521.18180824
27Phospholipase D signaling pathway_Homo sapiens_hsa040721.16947686
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.16039114
29Acute myeloid leukemia_Homo sapiens_hsa052211.13793274
30Pancreatic cancer_Homo sapiens_hsa052121.11997238
31T cell receptor signaling pathway_Homo sapiens_hsa046601.10995380
32Synaptic vesicle cycle_Homo sapiens_hsa047211.10798521
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10264360
34mTOR signaling pathway_Homo sapiens_hsa041501.07582965
35Long-term potentiation_Homo sapiens_hsa047201.07232971
36ErbB signaling pathway_Homo sapiens_hsa040121.06096052
37Long-term depression_Homo sapiens_hsa047301.04604918
38Longevity regulating pathway - mammal_Homo sapiens_hsa042111.01962860
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01487537
40Estrogen signaling pathway_Homo sapiens_hsa049151.00502216
41Insulin signaling pathway_Homo sapiens_hsa049100.99931492
42Hepatitis C_Homo sapiens_hsa051600.99404059
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98934242
44GnRH signaling pathway_Homo sapiens_hsa049120.97725013
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97493045
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97200706
47Lysosome_Homo sapiens_hsa041420.97161682
48Influenza A_Homo sapiens_hsa051640.96901840
49Platelet activation_Homo sapiens_hsa046110.95792072
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95052976
51MAPK signaling pathway_Homo sapiens_hsa040100.94611985
52Pertussis_Homo sapiens_hsa051330.91823103
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.91181195
54Axon guidance_Homo sapiens_hsa043600.90813205
55MicroRNAs in cancer_Homo sapiens_hsa052060.90715311
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90372760
57Colorectal cancer_Homo sapiens_hsa052100.89210641
58Gap junction_Homo sapiens_hsa045400.88789920
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88770872
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87751604
61Proteoglycans in cancer_Homo sapiens_hsa052050.87149137
62Bladder cancer_Homo sapiens_hsa052190.86998913
63Viral carcinogenesis_Homo sapiens_hsa052030.86439000
64Gastric acid secretion_Homo sapiens_hsa049710.85425653
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84476060
66Apoptosis_Homo sapiens_hsa042100.82506230
67Choline metabolism in cancer_Homo sapiens_hsa052310.81949159
68Rap1 signaling pathway_Homo sapiens_hsa040150.81654722
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81534190
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81040585
71Oxytocin signaling pathway_Homo sapiens_hsa049210.80991093
72Toxoplasmosis_Homo sapiens_hsa051450.80915695
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80761078
74Phagosome_Homo sapiens_hsa041450.79107722
75Endometrial cancer_Homo sapiens_hsa052130.78449991
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77482479
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77069144
78HIF-1 signaling pathway_Homo sapiens_hsa040660.75835879
79Focal adhesion_Homo sapiens_hsa045100.74891340
80Tight junction_Homo sapiens_hsa045300.74580673
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74412571
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73750125
83Ras signaling pathway_Homo sapiens_hsa040140.73195139
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73053345
85Thyroid cancer_Homo sapiens_hsa052160.71942768
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.71890132
87Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71635490
88Cholinergic synapse_Homo sapiens_hsa047250.71550905
89Viral myocarditis_Homo sapiens_hsa054160.71329265
90HTLV-I infection_Homo sapiens_hsa051660.71207856
91Salivary secretion_Homo sapiens_hsa049700.71107724
92Inositol phosphate metabolism_Homo sapiens_hsa005620.71037227
93Amoebiasis_Homo sapiens_hsa051460.70795983
94Hepatitis B_Homo sapiens_hsa051610.70665553
95Dopaminergic synapse_Homo sapiens_hsa047280.70471633
96Glutamatergic synapse_Homo sapiens_hsa047240.70266503
97AMPK signaling pathway_Homo sapiens_hsa041520.69903285
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68459643
99Pentose phosphate pathway_Homo sapiens_hsa000300.68373264
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68353036
101Type II diabetes mellitus_Homo sapiens_hsa049300.68264213
102GABAergic synapse_Homo sapiens_hsa047270.68154764
103Insulin resistance_Homo sapiens_hsa049310.68105577
104Notch signaling pathway_Homo sapiens_hsa043300.66222721
105TNF signaling pathway_Homo sapiens_hsa046680.64973936
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64808731
107Morphine addiction_Homo sapiens_hsa050320.64384251
108Fructose and mannose metabolism_Homo sapiens_hsa000510.64248042
109Alcoholism_Homo sapiens_hsa050340.63702380
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.63123555
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.62872827
112Small cell lung cancer_Homo sapiens_hsa052220.62820382
113Malaria_Homo sapiens_hsa051440.61932280
114Oocyte meiosis_Homo sapiens_hsa041140.61696226
115Prolactin signaling pathway_Homo sapiens_hsa049170.60971070
116Olfactory transduction_Homo sapiens_hsa047400.59905461
117Herpes simplex infection_Homo sapiens_hsa051680.59864315
118Prostate cancer_Homo sapiens_hsa052150.59540769
119Renin secretion_Homo sapiens_hsa049240.58717930
120FoxO signaling pathway_Homo sapiens_hsa040680.58407237
121Collecting duct acid secretion_Homo sapiens_hsa049660.58391217
122Primary immunodeficiency_Homo sapiens_hsa053400.58350665
123Antigen processing and presentation_Homo sapiens_hsa046120.58320007
124Vibrio cholerae infection_Homo sapiens_hsa051100.57368790
125Graft-versus-host disease_Homo sapiens_hsa053320.57259000
126Measles_Homo sapiens_hsa051620.57183772
127Rheumatoid arthritis_Homo sapiens_hsa053230.56487554
128Sulfur relay system_Homo sapiens_hsa041220.55543638

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