

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of gamma-delta T cell activation (GO:0046645) | 7.22513896 |
| 2 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 6.15462288 |
| 3 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 6.15462288 |
| 4 | regulation of gamma-delta T cell differentiation (GO:0045586) | 5.79110954 |
| 5 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.68199254 |
| 6 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 5.51192052 |
| 7 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 5.39406066 |
| 8 | negative T cell selection (GO:0043383) | 5.33522267 |
| 9 | regulation of gamma-delta T cell activation (GO:0046643) | 5.27962356 |
| 10 | negative thymic T cell selection (GO:0045060) | 5.24922183 |
| 11 | positive thymic T cell selection (GO:0045059) | 5.18419898 |
| 12 | ribosomal small subunit assembly (GO:0000028) | 5.12197350 |
| 13 | leukocyte aggregation (GO:0070486) | 4.77919834 |
| 14 | response to interleukin-15 (GO:0070672) | 4.68159372 |
| 15 | regulation of B cell receptor signaling pathway (GO:0050855) | 4.56883702 |
| 16 | cellular response to interleukin-15 (GO:0071350) | 4.56362325 |
| 17 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 4.53414653 |
| 18 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.47526456 |
| 19 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.47526456 |
| 20 | modulation by symbiont of host immune response (GO:0052553) | 4.47526456 |
| 21 | positive regulation by symbiont of host defense response (GO:0052509) | 4.47526456 |
| 22 | modulation by symbiont of host defense response (GO:0052031) | 4.47526456 |
| 23 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.47526456 |
| 24 | detection of bacterium (GO:0016045) | 4.45778383 |
| 25 | positive T cell selection (GO:0043368) | 4.42853891 |
| 26 | antigen processing and presentation via MHC class Ib (GO:0002475) | 4.41171519 |
| 27 | thymic T cell selection (GO:0045061) | 4.40815577 |
| 28 | detection of other organism (GO:0098543) | 4.37835782 |
| 29 | B cell receptor signaling pathway (GO:0050853) | 4.35159063 |
| 30 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 4.35036153 |
| 31 | regulation of B cell differentiation (GO:0045577) | 4.29828921 |
| 32 | negative regulation of cell killing (GO:0031342) | 4.15649482 |
| 33 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 4.15649482 |
| 34 | T cell selection (GO:0045058) | 4.10516477 |
| 35 | mast cell activation (GO:0045576) | 4.08468310 |
| 36 | T cell migration (GO:0072678) | 4.07692685 |
| 37 | viral transcription (GO:0019083) | 4.04130754 |
| 38 | tolerance induction (GO:0002507) | 4.01986459 |
| 39 | regulation of isotype switching to IgG isotypes (GO:0048302) | 4.00793784 |
| 40 | neutrophil activation involved in immune response (GO:0002283) | 3.96758631 |
| 41 | positive regulation of B cell differentiation (GO:0045579) | 3.95208663 |
| 42 | interferon-gamma production (GO:0032609) | 3.93487647 |
| 43 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.89158615 |
| 44 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.86921801 |
| 45 | negative regulation of T cell mediated immunity (GO:0002710) | 3.86775604 |
| 46 | translational termination (GO:0006415) | 3.83368267 |
| 47 | macrophage activation involved in immune response (GO:0002281) | 3.82958765 |
| 48 | regulation of interferon-beta biosynthetic process (GO:0045357) | 3.81196167 |
| 49 | T cell homeostasis (GO:0043029) | 3.78926241 |
| 50 | T cell receptor signaling pathway (GO:0050852) | 3.77190232 |
| 51 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.74032559 |
| 52 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.73386340 |
| 53 | activated T cell proliferation (GO:0050798) | 3.73309725 |
| 54 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.73084543 |
| 55 | regulation of regulatory T cell differentiation (GO:0045589) | 3.72763906 |
| 56 | cellular extravasation (GO:0045123) | 3.67089521 |
| 57 | T cell costimulation (GO:0031295) | 3.63162457 |
| 58 | lymphocyte costimulation (GO:0031294) | 3.60434679 |
| 59 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.54123911 |
| 60 | respiratory burst (GO:0045730) | 3.54096085 |
| 61 | mast cell degranulation (GO:0043303) | 3.52379679 |
| 62 | mast cell activation involved in immune response (GO:0002279) | 3.52379679 |
| 63 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.43577516 |
| 64 | regulation of tolerance induction (GO:0002643) | 3.43389284 |
| 65 | translational elongation (GO:0006414) | 3.41463459 |
| 66 | neutrophil activation (GO:0042119) | 3.38787935 |
| 67 | ribosomal small subunit biogenesis (GO:0042274) | 3.38623099 |
| 68 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.35510035 |
| 69 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.34827987 |
| 70 | detection of external biotic stimulus (GO:0098581) | 3.33036729 |
| 71 | megakaryocyte development (GO:0035855) | 3.30237551 |
| 72 | negative regulation of interleukin-12 production (GO:0032695) | 3.29610432 |
| 73 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.27808950 |
| 74 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 3.27389580 |
| 75 | response to muramyl dipeptide (GO:0032495) | 3.26643897 |
| 76 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 3.25388656 |
| 77 | positive regulation of granulocyte differentiation (GO:0030854) | 3.25237683 |
| 78 | myeloid cell activation involved in immune response (GO:0002275) | 3.23732344 |
| 79 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.21269446 |
| 80 | positive regulation of tolerance induction (GO:0002645) | 3.20018256 |
| 81 | cotranslational protein targeting to membrane (GO:0006613) | 3.19867339 |
| 82 | DNA deamination (GO:0045006) | 3.19350319 |
| 83 | protein targeting to ER (GO:0045047) | 3.17798018 |
| 84 | negative regulation of innate immune response (GO:0045824) | 3.16833187 |
| 85 | NIK/NF-kappaB signaling (GO:0038061) | 3.15261231 |
| 86 | lymphocyte homeostasis (GO:0002260) | 3.12511280 |
| 87 | regulation of T cell tolerance induction (GO:0002664) | 3.12360716 |
| 88 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.12249415 |
| 89 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.12249415 |
| 90 | response to peptidoglycan (GO:0032494) | 3.11402772 |
| 91 | regulation of antigen processing and presentation (GO:0002577) | 3.09338085 |
| 92 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.07409115 |
| 93 | lymph node development (GO:0048535) | 3.06940713 |
| 94 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.05888406 |
| 95 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.05888406 |
| 96 | sequestering of actin monomers (GO:0042989) | 3.05191305 |
| 97 | granulocyte activation (GO:0036230) | 3.04902674 |
| 98 | response to host immune response (GO:0052572) | 3.04022189 |
| 99 | response to immune response of other organism involved in symbiotic interaction (GO:0052564) | 3.04022189 |
| 100 | positive regulation of interleukin-2 production (GO:0032743) | 3.03756741 |
| 101 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.03437520 |
| 102 | B cell mediated immunity (GO:0019724) | 3.02836641 |
| 103 | defense response to protozoan (GO:0042832) | 3.01934345 |
| 104 | response to type I interferon (GO:0034340) | 3.01773526 |
| 105 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.01770646 |
| 106 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.01681556 |
| 107 | leukocyte degranulation (GO:0043299) | 3.01004546 |
| 108 | viral life cycle (GO:0019058) | 3.00710225 |
| 109 | protein localization to endoplasmic reticulum (GO:0070972) | 3.00566849 |
| 110 | Peyers patch development (GO:0048541) | 2.99728449 |
| 111 | mucosal-associated lymphoid tissue development (GO:0048537) | 2.99728449 |
| 112 | positive regulation of isotype switching (GO:0045830) | 2.98520309 |
| 113 | T cell differentiation (GO:0030217) | 2.98330679 |
| 114 | type I interferon signaling pathway (GO:0060337) | 2.98059000 |
| 115 | cellular response to type I interferon (GO:0071357) | 2.98059000 |
| 116 | regulation of mast cell degranulation (GO:0043304) | 2.97881318 |
| 117 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 2.97470890 |
| 118 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 2.97261065 |
| 119 | response to protozoan (GO:0001562) | 2.96141819 |
| 120 | leukocyte homeostasis (GO:0001776) | 2.94477749 |
| 121 | positive regulation of humoral immune response (GO:0002922) | 2.94054056 |
| 122 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 2.93068997 |
| 123 | microglial cell activation (GO:0001774) | 2.92972891 |
| 124 | negative regulation of phagocytosis (GO:0050765) | 2.92924916 |
| 125 | regulation of B cell mediated immunity (GO:0002712) | 2.92575069 |
| 126 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.92120418 |
| 127 | immunoglobulin mediated immune response (GO:0016064) | 2.90459262 |
| 128 | negative regulation of antigen receptor-mediated signaling pathway (GO:0050858) | 2.90334279 |
| 129 | dendritic cell chemotaxis (GO:0002407) | 2.89979215 |
| 130 | natural killer cell activation (GO:0030101) | 2.89673287 |
| 131 | myeloid dendritic cell activation (GO:0001773) | 2.89454307 |
| 132 | positive regulation of antigen processing and presentation (GO:0002579) | 2.89214944 |
| 133 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.88929411 |
| 134 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.88864788 |
| 135 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.88864788 |
| 136 | mature B cell differentiation involved in immune response (GO:0002313) | 2.88258088 |
| 137 | cellular protein complex disassembly (GO:0043624) | 2.86897015 |
| 138 | positive regulation of immunoglobulin production (GO:0002639) | 2.86645847 |
| 139 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 2.86020926 |
| 140 | negative regulation of T cell receptor signaling pathway (GO:0050860) | 2.85741692 |
| 141 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 2.85204099 |
| 142 | regulation of immunoglobulin mediated immune response (GO:0002889) | 2.84937913 |
| 143 | positive regulation of lamellipodium assembly (GO:0010592) | 2.84751308 |
| 144 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 2.84667052 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.60909395 |
| 2 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 4.25948906 |
| 3 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.22830956 |
| 4 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.89147191 |
| 5 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.78910640 |
| 6 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.29275194 |
| 7 | MYC_22102868_ChIP-Seq_BL_Human | 3.28197353 |
| 8 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 3.14563848 |
| 9 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.92771968 |
| 10 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.87796278 |
| 11 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.81580084 |
| 12 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.64230061 |
| 13 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.61772724 |
| 14 | * MYB_26560356_Chip-Seq_TH2_Human | 2.54578655 |
| 15 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 2.54170218 |
| 16 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.53026041 |
| 17 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 2.52774154 |
| 18 | VDR_21846776_ChIP-Seq_THP-1_Human | 2.50892717 |
| 19 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.49647178 |
| 20 | RUNX_20019798_ChIP-Seq_JUKART_Human | 2.47902436 |
| 21 | * FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.46115404 |
| 22 | MAF_26560356_Chip-Seq_TH1_Human | 2.45211976 |
| 23 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.34385665 |
| 24 | MYB_26560356_Chip-Seq_TH1_Human | 2.32126954 |
| 25 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.29307821 |
| 26 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.25050772 |
| 27 | * UTX_26944678_Chip-Seq_JUKART_Human | 2.23278170 |
| 28 | * SPI1_23547873_ChIP-Seq_NB4_Human | 2.23118465 |
| 29 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.08709624 |
| 30 | * KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.99066188 |
| 31 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.98566324 |
| 32 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.95126066 |
| 33 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.93620294 |
| 34 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.89438860 |
| 35 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.89067036 |
| 36 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.87039748 |
| 37 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.85823710 |
| 38 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.81854502 |
| 39 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.81666095 |
| 40 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.78360010 |
| 41 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.77784436 |
| 42 | * E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.77747812 |
| 43 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.76253477 |
| 44 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.75024708 |
| 45 | MAF_26560356_Chip-Seq_TH2_Human | 1.70262532 |
| 46 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.70006142 |
| 47 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.66470478 |
| 48 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.66066448 |
| 49 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.64633061 |
| 50 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 1.64140991 |
| 51 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.62493880 |
| 52 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.61169963 |
| 53 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.57643007 |
| 54 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.57369936 |
| 55 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.54889339 |
| 56 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.53754203 |
| 57 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.52776883 |
| 58 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.51784300 |
| 59 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.47420802 |
| 60 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.46634408 |
| 61 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.41178208 |
| 62 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.38607865 |
| 63 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.36735471 |
| 64 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.36719438 |
| 65 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.36569585 |
| 66 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.36516776 |
| 67 | GATA1_22025678_ChIP-Seq_K562_Human | 1.35156125 |
| 68 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.35036914 |
| 69 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.34932454 |
| 70 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.33589630 |
| 71 | * KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.32068227 |
| 72 | * KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.31232795 |
| 73 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.30548047 |
| 74 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.29102527 |
| 75 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.28068022 |
| 76 | SPI1_23127762_ChIP-Seq_K562_Human | 1.25469651 |
| 77 | * BCOR_27268052_Chip-Seq_Bcells_Human | 1.25074603 |
| 78 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.24077122 |
| 79 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.23183599 |
| 80 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.21870904 |
| 81 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.20239593 |
| 82 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.19412049 |
| 83 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.19365588 |
| 84 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 1.18714345 |
| 85 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.18595885 |
| 86 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.16442997 |
| 87 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.15872347 |
| 88 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.15870988 |
| 89 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.14759861 |
| 90 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.14135721 |
| 91 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.13373587 |
| 92 | GATA1_19941826_ChIP-Seq_K562_Human | 1.12878812 |
| 93 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.12303338 |
| 94 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.12165777 |
| 95 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.11490324 |
| 96 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.09742664 |
| 97 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.09391228 |
| 98 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.08382575 |
| 99 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.07974256 |
| 100 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.07642912 |
| 101 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.07229179 |
| 102 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.06757172 |
| 103 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.06590881 |
| 104 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.05616276 |
| 105 | GATA3_26560356_Chip-Seq_TH2_Human | 1.03487790 |
| 106 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.01426306 |
| 107 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.00762028 |
| 108 | P68_20966046_ChIP-Seq_HELA_Human | 1.00346346 |
| 109 | * SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.00142388 |
| 110 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.99541922 |
| 111 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 0.98168325 |
| 112 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.98105428 |
| 113 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.96586515 |
| 114 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.94833747 |
| 115 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94433236 |
| 116 | * CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.93463938 |
| 117 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.93419849 |
| 118 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.93129260 |
| 119 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.92349815 |
| 120 | * P300_27268052_Chip-Seq_Bcells_Human | 0.91194105 |
| 121 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.90922658 |
| 122 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.89331465 |
| 123 | * SPI1_20517297_ChIP-Seq_HL60_Human | 0.88571183 |
| 124 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.87686243 |
| 125 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.87659697 |
| 126 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 0.85868197 |
| 127 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.85617702 |
| 128 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 0.85359405 |
| 129 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.83455243 |
| 130 | * BCL6_27268052_Chip-Seq_Bcells_Human | 0.83398724 |
| 131 | RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.82109127 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005671_abnormal_response_to | 4.50284370 |
| 2 | MP0003763_abnormal_thymus_physiology | 4.49500117 |
| 3 | MP0001835_abnormal_antigen_presentation | 4.07098495 |
| 4 | MP0000685_abnormal_immune_system | 3.94825146 |
| 5 | MP0002396_abnormal_hematopoietic_system | 3.67746175 |
| 6 | MP0001800_abnormal_humoral_immune | 3.42203518 |
| 7 | MP0001790_abnormal_immune_system | 3.06179910 |
| 8 | MP0005387_immune_system_phenotype | 3.06179910 |
| 9 | MP0009785_altered_susceptibility_to | 3.05071479 |
| 10 | MP0002398_abnormal_bone_marrow | 2.98514154 |
| 11 | MP0002420_abnormal_adaptive_immunity | 2.92831189 |
| 12 | MP0001819_abnormal_immune_cell | 2.86993500 |
| 13 | MP0002723_abnormal_immune_serum | 2.83341992 |
| 14 | MP0002452_abnormal_antigen_presenting | 2.80849862 |
| 15 | MP0005000_abnormal_immune_tolerance | 2.80212098 |
| 16 | MP0002166_altered_tumor_susceptibility | 2.74320433 |
| 17 | MP0000716_abnormal_immune_system | 2.57188762 |
| 18 | MP0005025_abnormal_response_to | 2.53852504 |
| 19 | MP0000689_abnormal_spleen_morphology | 2.46232053 |
| 20 | MP0002722_abnormal_immune_system | 2.43498009 |
| 21 | MP0003436_decreased_susceptibility_to | 2.34438462 |
| 22 | MP0000703_abnormal_thymus_morphology | 2.32911417 |
| 23 | MP0009333_abnormal_splenocyte_physiolog | 2.31149490 |
| 24 | MP0004808_abnormal_hematopoietic_stem | 2.29258058 |
| 25 | MP0005464_abnormal_platelet_physiology | 2.20987322 |
| 26 | MP0002429_abnormal_blood_cell | 2.20361092 |
| 27 | MP0001873_stomach_inflammation | 2.19780051 |
| 28 | MP0002405_respiratory_system_inflammati | 2.18078672 |
| 29 | MP0010155_abnormal_intestine_physiology | 2.13930281 |
| 30 | MP0002006_tumorigenesis | 2.12025916 |
| 31 | MP0003866_abnormal_defecation | 2.04288953 |
| 32 | MP0002148_abnormal_hypersensitivity_rea | 1.99154964 |
| 33 | MP0002419_abnormal_innate_immunity | 1.97751476 |
| 34 | MP0003724_increased_susceptibility_to | 1.87662073 |
| 35 | MP0005075_abnormal_melanosome_morpholog | 1.77993057 |
| 36 | MP0000465_gastrointestinal_hemorrhage | 1.73316199 |
| 37 | MP0006082_CNS_inflammation | 1.68984159 |
| 38 | MP0001845_abnormal_inflammatory_respons | 1.65424068 |
| 39 | MP0004947_skin_inflammation | 1.61325674 |
| 40 | MP0001853_heart_inflammation | 1.61092285 |
| 41 | MP0005397_hematopoietic_system_phenotyp | 1.60345549 |
| 42 | MP0001545_abnormal_hematopoietic_system | 1.60345549 |
| 43 | MP0005174_abnormal_tail_pigmentation | 1.58563419 |
| 44 | MP0000490_abnormal_crypts_of | 1.57840065 |
| 45 | MP0002933_joint_inflammation | 1.55809760 |
| 46 | MP0003300_gastrointestinal_ulcer | 1.35418900 |
| 47 | MP0008260_abnormal_autophagy | 1.34131266 |
| 48 | MP0002019_abnormal_tumor_incidence | 1.30399977 |
| 49 | MP0002138_abnormal_hepatobiliary_system | 1.25848676 |
| 50 | MP0003693_abnormal_embryo_hatching | 1.24827625 |
| 51 | MP0002095_abnormal_skin_pigmentation | 1.24227203 |
| 52 | MP0010094_abnormal_chromosome_stability | 1.23695429 |
| 53 | MP0003077_abnormal_cell_cycle | 1.19347315 |
| 54 | MP0008469_abnormal_protein_level | 1.19187009 |
| 55 | MP0002132_abnormal_respiratory_system | 1.18604262 |
| 56 | MP0000858_altered_metastatic_potential | 1.17101276 |
| 57 | MP0008058_abnormal_DNA_repair | 1.15865919 |
| 58 | MP0008057_abnormal_DNA_replication | 1.14541053 |
| 59 | MP0003303_peritoneal_inflammation | 1.11434391 |
| 60 | MP0002277_abnormal_respiratory_mucosa | 1.11203185 |
| 61 | MP0008007_abnormal_cellular_replicative | 1.06638021 |
| 62 | MP0009278_abnormal_bone_marrow | 1.04197273 |
| 63 | MP0004957_abnormal_blastocyst_morpholog | 0.96489341 |
| 64 | MP0005310_abnormal_salivary_gland | 0.94401253 |
| 65 | MP0002009_preneoplasia | 0.92749278 |
| 66 | MP0004883_abnormal_blood_vessel | 0.92513021 |
| 67 | MP0001533_abnormal_skeleton_physiology | 0.90779906 |
| 68 | MP0005451_abnormal_body_composition | 0.89336167 |
| 69 | MP0005166_decreased_susceptibility_to | 0.84732563 |
| 70 | MP0000015_abnormal_ear_pigmentation | 0.83138225 |
| 71 | MP0003045_fibrosis | 0.80486748 |
| 72 | MP0004381_abnormal_hair_follicle | 0.79123614 |
| 73 | MP0003183_abnormal_peptide_metabolism | 0.79059976 |
| 74 | MP0001986_abnormal_taste_sensitivity | 0.78622009 |
| 75 | MP0004510_myositis | 0.78539217 |
| 76 | MP0003111_abnormal_nucleus_morphology | 0.77821807 |
| 77 | MP0003943_abnormal_hepatobiliary_system | 0.77481272 |
| 78 | MP0003690_abnormal_glial_cell | 0.76713222 |
| 79 | MP0000313_abnormal_cell_death | 0.73612547 |
| 80 | MP0005390_skeleton_phenotype | 0.73157269 |
| 81 | MP0003448_altered_tumor_morphology | 0.72488849 |
| 82 | MP0009763_increased_sensitivity_to | 0.71472358 |
| 83 | MP0010352_gastrointestinal_tract_polyps | 0.70206679 |
| 84 | MP0009764_decreased_sensitivity_to | 0.69008870 |
| 85 | MP0000477_abnormal_intestine_morphology | 0.68256505 |
| 86 | MP0006054_spinal_hemorrhage | 0.67734862 |
| 87 | MP0009765_abnormal_xenobiotic_induced | 0.67035551 |
| 88 | MP0004130_abnormal_muscle_cell | 0.66619668 |
| 89 | MP0005023_abnormal_wound_healing | 0.63913990 |
| 90 | MP0005058_abnormal_lysosome_morphology | 0.62148024 |
| 91 | MP0005164_abnormal_response_to | 0.61771705 |
| 92 | MP0003075_altered_response_to | 0.61435875 |
| 93 | MP0003795_abnormal_bone_structure | 0.60814433 |
| 94 | MP0001851_eye_inflammation | 0.57556773 |
| 95 | MP0002928_abnormal_bile_duct | 0.56954427 |
| 96 | MP0001663_abnormal_digestive_system | 0.56545590 |
| 97 | MP0002693_abnormal_pancreas_physiology | 0.55995959 |
| 98 | MP0009379_abnormal_foot_pigmentation | 0.55094327 |
| 99 | MP0004147_increased_porphyrin_level | 0.53511461 |
| 100 | MP0003786_premature_aging | 0.53354688 |
| 101 | MP0001191_abnormal_skin_condition | 0.52906575 |
| 102 | MP0008004_abnormal_stomach_pH | 0.52438362 |
| 103 | MP0000604_amyloidosis | 0.51714384 |
| 104 | MP0003806_abnormal_nucleotide_metabolis | 0.46667569 |
| 105 | MP0005381_digestive/alimentary_phenotyp | 0.45737412 |
| 106 | MP0000350_abnormal_cell_proliferation | 0.45223526 |
| 107 | MP0009840_abnormal_foam_cell | 0.44626985 |
| 108 | MP0008873_increased_physiological_sensi | 0.44291537 |
| 109 | MP0003252_abnormal_bile_duct | 0.44226020 |
| 110 | MP0000343_altered_response_to | 0.44161615 |
| 111 | MP0003191_abnormal_cellular_cholesterol | 0.43804032 |
| 112 | MP0000598_abnormal_liver_morphology | 0.42992174 |
| 113 | MP0002136_abnormal_kidney_physiology | 0.42559908 |
| 114 | MP0000609_abnormal_liver_physiology | 0.42009783 |
| 115 | MP0008961_abnormal_basal_metabolism | 0.41325696 |
| 116 | MP0003656_abnormal_erythrocyte_physiolo | 0.41274408 |
| 117 | MP0003828_pulmonary_edema | 0.41031187 |
| 118 | MP0002998_abnormal_bone_remodeling | 0.40742882 |
| 119 | MP0000249_abnormal_blood_vessel | 0.40133710 |
| 120 | MP0002083_premature_death | 0.39362352 |
| 121 | MP0009642_abnormal_blood_homeostasis | 0.38510767 |
| 122 | MP0003172_abnormal_lysosome_physiology | 0.38498328 |
| 123 | MP0001348_abnormal_lacrimal_gland | 0.38459548 |
| 124 | MP0001765_abnormal_ion_homeostasis | 0.37835071 |
| 125 | MP0008874_decreased_physiological_sensi | 0.37803151 |
| 126 | MP0009931_abnormal_skin_appearance | 0.37395546 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Recurrent bronchitis (HP:0002837) | 5.55334160 |
| 2 | IgM deficiency (HP:0002850) | 5.33857183 |
| 3 | T lymphocytopenia (HP:0005403) | 5.25581428 |
| 4 | Agammaglobulinemia (HP:0004432) | 5.08921594 |
| 5 | Abnormality of T cell number (HP:0011839) | 5.02088274 |
| 6 | Elevated erythrocyte sedimentation rate (HP:0003565) | 4.86115540 |
| 7 | Chronic otitis media (HP:0000389) | 4.82829914 |
| 8 | Abnormality of macrophages (HP:0004311) | 4.69943514 |
| 9 | Panhypogammaglobulinemia (HP:0003139) | 4.64304001 |
| 10 | Abnormality of T cells (HP:0002843) | 4.56193554 |
| 11 | IgG deficiency (HP:0004315) | 4.26799604 |
| 12 | Severe combined immunodeficiency (HP:0004430) | 4.21061012 |
| 13 | Recurrent viral infections (HP:0004429) | 4.10502138 |
| 14 | Recurrent gram-negative bacterial infections (HP:0005420) | 4.07810712 |
| 15 | Lymphopenia (HP:0001888) | 4.03437698 |
| 16 | Gastrointestinal infarctions (HP:0005244) | 3.97746170 |
| 17 | Combined immunodeficiency (HP:0005387) | 3.94318976 |
| 18 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.93284270 |
| 19 | Abnormality of B cell number (HP:0010975) | 3.91735878 |
| 20 | B lymphocytopenia (HP:0010976) | 3.91735878 |
| 21 | Myositis (HP:0100614) | 3.89326607 |
| 22 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 3.87992891 |
| 23 | Thrombocytosis (HP:0001894) | 3.85357450 |
| 24 | Thyroiditis (HP:0100646) | 3.84000946 |
| 25 | Recurrent fungal infections (HP:0002841) | 3.78023445 |
| 26 | Nasal polyposis (HP:0100582) | 3.74164122 |
| 27 | Abnormality of T cell physiology (HP:0011840) | 3.69990955 |
| 28 | Meningitis (HP:0001287) | 3.66152521 |
| 29 | Gastrointestinal stroma tumor (HP:0100723) | 3.64559858 |
| 30 | Recurrent cutaneous fungal infections (HP:0011370) | 3.62707318 |
| 31 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.62707318 |
| 32 | Recurrent sinusitis (HP:0011108) | 3.57700271 |
| 33 | Abnormality of the nasal mucosa (HP:0000433) | 3.32078265 |
| 34 | Recurrent abscess formation (HP:0002722) | 3.31234442 |
| 35 | Hypoplasia of the thymus (HP:0000778) | 3.25140423 |
| 36 | Cellulitis (HP:0100658) | 3.16442116 |
| 37 | Gastrointestinal inflammation (HP:0004386) | 3.16157067 |
| 38 | Lymphoma (HP:0002665) | 3.15708892 |
| 39 | Inflammation of the large intestine (HP:0002037) | 3.14825655 |
| 40 | Bronchitis (HP:0012387) | 3.14483494 |
| 41 | Chronic diarrhea (HP:0002028) | 3.13270537 |
| 42 | Abnormality of eosinophils (HP:0001879) | 3.08855837 |
| 43 | Chronic sinusitis (HP:0011109) | 3.04775266 |
| 44 | Aplastic anemia (HP:0001915) | 3.03745347 |
| 45 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.03511013 |
| 46 | Vasculitis (HP:0002633) | 3.01076358 |
| 47 | Petechiae (HP:0000967) | 2.99346809 |
| 48 | Abnormal number of erythroid precursors (HP:0012131) | 2.97844037 |
| 49 | Hypochromic anemia (HP:0001931) | 2.93794417 |
| 50 | Urticaria (HP:0001025) | 2.93751167 |
| 51 | Keratoconjunctivitis (HP:0001096) | 2.92433697 |
| 52 | Abnormality of the fingertips (HP:0001211) | 2.90323596 |
| 53 | Gingivitis (HP:0000230) | 2.89276770 |
| 54 | Pustule (HP:0200039) | 2.87571047 |
| 55 | Stomatitis (HP:0010280) | 2.84134141 |
| 56 | Prolonged bleeding time (HP:0003010) | 2.80440244 |
| 57 | Colitis (HP:0002583) | 2.80100554 |
| 58 | Eczematoid dermatitis (HP:0000976) | 2.79389227 |
| 59 | Papilloma (HP:0012740) | 2.78738632 |
| 60 | Verrucae (HP:0200043) | 2.78738632 |
| 61 | Hypochromic microcytic anemia (HP:0004840) | 2.73716791 |
| 62 | Leukocytosis (HP:0001974) | 2.72742031 |
| 63 | Basal cell carcinoma (HP:0002671) | 2.71895730 |
| 64 | Encephalitis (HP:0002383) | 2.70833304 |
| 65 | Reticulocytopenia (HP:0001896) | 2.69967870 |
| 66 | IgA deficiency (HP:0002720) | 2.66652248 |
| 67 | Granulocytopenia (HP:0001913) | 2.66172523 |
| 68 | Recurrent skin infections (HP:0001581) | 2.65835393 |
| 69 | Autoimmune hemolytic anemia (HP:0001890) | 2.64172497 |
| 70 | Recurrent bacterial skin infections (HP:0005406) | 2.64010173 |
| 71 | Eosinophilia (HP:0001880) | 2.63003010 |
| 72 | Autoimmune thrombocytopenia (HP:0001973) | 2.61981657 |
| 73 | Colon cancer (HP:0003003) | 2.57941203 |
| 74 | Epistaxis (HP:0000421) | 2.52131402 |
| 75 | Spontaneous hematomas (HP:0007420) | 2.48398586 |
| 76 | Amaurosis fugax (HP:0100576) | 2.47801018 |
| 77 | Episodic fever (HP:0001954) | 2.45664947 |
| 78 | Pulmonary embolism (HP:0002204) | 2.43558094 |
| 79 | Recurrent otitis media (HP:0000403) | 2.43358625 |
| 80 | Emphysema (HP:0002097) | 2.42695361 |
| 81 | Mediastinal lymphadenopathy (HP:0100721) | 2.40639201 |
| 82 | Papilledema (HP:0001085) | 2.39849126 |
| 83 | Gingival bleeding (HP:0000225) | 2.38335920 |
| 84 | Poikiloderma (HP:0001029) | 2.33307360 |
| 85 | Arterial thrombosis (HP:0004420) | 2.32440296 |
| 86 | Anorexia (HP:0002039) | 2.28672023 |
| 87 | Chronic obstructive pulmonary disease (HP:0006510) | 2.27499918 |
| 88 | Obstructive lung disease (HP:0006536) | 2.27499918 |
| 89 | Abnormality of the prostate (HP:0008775) | 2.24558199 |
| 90 | Retrobulbar optic neuritis (HP:0100654) | 2.23736019 |
| 91 | Optic neuritis (HP:0100653) | 2.23736019 |
| 92 | Abnormality of the pleura (HP:0002103) | 2.22057528 |
| 93 | Hypergammaglobulinemia (HP:0010702) | 2.21360073 |
| 94 | Increased IgM level (HP:0003496) | 2.20252698 |
| 95 | Hypoproteinemia (HP:0003075) | 2.18912286 |
| 96 | Orchitis (HP:0100796) | 2.18592226 |
| 97 | Sepsis (HP:0100806) | 2.16982989 |
| 98 | Slow saccadic eye movements (HP:0000514) | 2.15607906 |
| 99 | Skin rash (HP:0000988) | 2.15115853 |
| 100 | Increased IgE level (HP:0003212) | 2.11799749 |
| 101 | Restrictive lung disease (HP:0002091) | 2.11551583 |
| 102 | Microcytic anemia (HP:0001935) | 2.09163673 |
| 103 | Hemoptysis (HP:0002105) | 2.08875407 |
| 104 | Recurrent pneumonia (HP:0006532) | 2.05399660 |
| 105 | Acute hepatic failure (HP:0006554) | 2.04837002 |
| 106 | Gangrene (HP:0100758) | 2.04252220 |
| 107 | Joint swelling (HP:0001386) | 2.03281789 |
| 108 | Viral hepatitis (HP:0006562) | 2.03217045 |
| 109 | Neutropenia (HP:0001875) | 2.02302625 |
| 110 | Osteomyelitis (HP:0002754) | 2.00460089 |
| 111 | Pulmonary infiltrates (HP:0002113) | 1.99258062 |
| 112 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 1.97579643 |
| 113 | Entropion (HP:0000621) | 1.97413169 |
| 114 | Premature loss of primary teeth (HP:0006323) | 1.97024038 |
| 115 | Pallor (HP:0000980) | 1.96730038 |
| 116 | Glomerulopathy (HP:0100820) | 1.95215902 |
| 117 | Purpura (HP:0000979) | 1.94361420 |
| 118 | Aplasia/Hypoplasia of the thymus (HP:0010515) | 1.93712673 |
| 119 | Muscle fiber atrophy (HP:0100295) | 1.93102775 |
| 120 | Skin ulcer (HP:0200042) | 1.91907636 |
| 121 | Chest pain (HP:0100749) | 1.89727392 |
| 122 | Interstitial pulmonary disease (HP:0006530) | 1.89362837 |
| 123 | Keratoconjunctivitis sicca (HP:0001097) | 1.88480059 |
| 124 | Recurrent lower respiratory tract infections (HP:0002783) | 1.87915719 |
| 125 | Abnormal platelet function (HP:0011869) | 1.87563751 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K1 | 5.73035740 |
| 2 | TXK | 3.99863687 |
| 3 | ZAP70 | 3.06452356 |
| 4 | KIT | 2.73201832 |
| 5 | PRPF4B | 2.54787262 |
| 6 | BTK | 2.40020306 |
| 7 | STK10 | 2.32726848 |
| 8 | JAK3 | 2.32220522 |
| 9 | TEC | 2.23175861 |
| 10 | FLT3 | 2.23125285 |
| 11 | TYK2 | 2.16329266 |
| 12 | IKBKE | 2.12859193 |
| 13 | NME2 | 2.11801726 |
| 14 | ITK | 2.11650910 |
| 15 | SYK | 2.03598299 |
| 16 | GRK6 | 2.01873675 |
| 17 | KDR | 1.91372414 |
| 18 | CSF1R | 1.88591812 |
| 19 | EEF2K | 1.86327986 |
| 20 | NLK | 1.84101097 |
| 21 | LCK | 1.77660821 |
| 22 | TBK1 | 1.77090277 |
| 23 | BLK | 1.70291130 |
| 24 | MAP2K3 | 1.69806293 |
| 25 | MAP3K10 | 1.56197343 |
| 26 | MAP3K12 | 1.52577786 |
| 27 | LRRK2 | 1.44142674 |
| 28 | CLK1 | 1.42833752 |
| 29 | EPHB1 | 1.37175195 |
| 30 | IRAK4 | 1.35508087 |
| 31 | FGFR4 | 1.34625941 |
| 32 | TGFBR1 | 1.30277235 |
| 33 | HCK | 1.29013472 |
| 34 | JAK1 | 1.27131075 |
| 35 | LYN | 1.22880528 |
| 36 | MAP3K14 | 1.21959627 |
| 37 | MAP2K6 | 1.15211063 |
| 38 | TESK2 | 1.13761869 |
| 39 | TAOK1 | 1.13102923 |
| 40 | FES | 1.10840574 |
| 41 | STK16 | 1.10643658 |
| 42 | CSK | 1.08328411 |
| 43 | MAP3K3 | 1.07465271 |
| 44 | PKN2 | 1.05634645 |
| 45 | MARK3 | 1.05271214 |
| 46 | ERN1 | 1.03350457 |
| 47 | PIM1 | 1.03105417 |
| 48 | FGR | 1.02799567 |
| 49 | MAP3K13 | 1.01791787 |
| 50 | IKBKB | 1.01657544 |
| 51 | TRIB3 | 1.00424941 |
| 52 | TNIK | 0.99959877 |
| 53 | RPS6KB2 | 0.97958765 |
| 54 | TNK2 | 0.93970119 |
| 55 | MAP3K1 | 0.90516278 |
| 56 | PRKD2 | 0.88915074 |
| 57 | SIK2 | 0.87636254 |
| 58 | MST4 | 0.86944130 |
| 59 | RPS6KA4 | 0.85111799 |
| 60 | PASK | 0.84981759 |
| 61 | FGFR3 | 0.84847191 |
| 62 | MAP3K7 | 0.83157838 |
| 63 | CAMKK1 | 0.82208147 |
| 64 | CAMKK2 | 0.80049169 |
| 65 | TGFBR2 | 0.79841982 |
| 66 | ACVR1B | 0.78026175 |
| 67 | MAP2K2 | 0.76634013 |
| 68 | NEK2 | 0.72655661 |
| 69 | SIK3 | 0.72156270 |
| 70 | PRKCQ | 0.72021697 |
| 71 | SMG1 | 0.71807641 |
| 72 | MAP3K6 | 0.69093788 |
| 73 | CCNB1 | 0.69012179 |
| 74 | ADRBK2 | 0.68074015 |
| 75 | BMPR2 | 0.67921300 |
| 76 | CDC42BPA | 0.64231142 |
| 77 | PTK6 | 0.63421595 |
| 78 | CDK4 | 0.62867515 |
| 79 | MAPK7 | 0.62668621 |
| 80 | CDC7 | 0.61995719 |
| 81 | TAOK2 | 0.59086115 |
| 82 | KSR2 | 0.58220222 |
| 83 | EIF2AK3 | 0.57923785 |
| 84 | MATK | 0.57046478 |
| 85 | RIPK4 | 0.56786711 |
| 86 | CDK19 | 0.56723267 |
| 87 | MARK2 | 0.53773284 |
| 88 | YES1 | 0.53082921 |
| 89 | SIK1 | 0.52935921 |
| 90 | PIM2 | 0.52361148 |
| 91 | MAPK4 | 0.51261645 |
| 92 | CDK12 | 0.50314179 |
| 93 | PRKCH | 0.49558400 |
| 94 | STK4 | 0.48643148 |
| 95 | DYRK1B | 0.48129071 |
| 96 | PDPK1 | 0.47661142 |
| 97 | WEE1 | 0.47393019 |
| 98 | TLK1 | 0.47342971 |
| 99 | ILK | 0.46611469 |
| 100 | PIK3CG | 0.46050592 |
| 101 | STK11 | 0.45784763 |
| 102 | BUB1 | 0.44946237 |
| 103 | MAPK11 | 0.44714680 |
| 104 | JAK2 | 0.44711804 |
| 105 | RPS6KC1 | 0.44312281 |
| 106 | RPS6KL1 | 0.44312281 |
| 107 | ATR | 0.43398782 |
| 108 | IRAK1 | 0.43028727 |
| 109 | VRK1 | 0.41250814 |
| 110 | TAOK3 | 0.40249352 |
| 111 | HIPK2 | 0.36631713 |
| 112 | CHUK | 0.35712926 |
| 113 | MAPKAPK2 | 0.34565941 |
| 114 | PRKG2 | 0.33982926 |
| 115 | DYRK3 | 0.31428837 |
| 116 | CDK9 | 0.30488996 |
| 117 | EIF2AK1 | 0.30483064 |
| 118 | RAF1 | 0.30295534 |
| 119 | STK38 | 0.30019286 |
| 120 | PTK2B | 0.29560727 |
| 121 | MAPK12 | 0.29498927 |
| 122 | FYN | 0.28654676 |
| 123 | MYLK | 0.28516600 |
| 124 | IRAK3 | 0.28447652 |
| 125 | PDK1 | 0.28192004 |
| 126 | RET | 0.27730332 |
| 127 | MAP3K11 | 0.27548851 |
| 128 | RPS6KA6 | 0.27333029 |
| 129 | AURKB | 0.27298249 |
| 130 | IRAK2 | 0.27228274 |
| 131 | MAP3K5 | 0.26818459 |
| 132 | MAPK3 | 0.26434159 |
| 133 | CAMK1 | 0.26312565 |
| 134 | BMX | 0.24996886 |
| 135 | SGK3 | 0.23974692 |
| 136 | ABL1 | 0.23716685 |
| 137 | CDK6 | 0.22812294 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 5.75372912 |
| 2 | Ribosome_Homo sapiens_hsa03010 | 3.14169360 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 2.89017965 |
| 4 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.66081402 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 2.59349690 |
| 6 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 2.58312615 |
| 7 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.57311423 |
| 8 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.44762940 |
| 9 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.40909111 |
| 10 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.37169418 |
| 11 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.35919300 |
| 12 | Measles_Homo sapiens_hsa05162 | 2.31173637 |
| 13 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.29833498 |
| 14 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.13055627 |
| 15 | Base excision repair_Homo sapiens_hsa03410 | 2.11686717 |
| 16 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.98535995 |
| 17 | Leishmaniasis_Homo sapiens_hsa05140 | 1.84701175 |
| 18 | Allograft rejection_Homo sapiens_hsa05330 | 1.71743602 |
| 19 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.69416821 |
| 20 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.64877103 |
| 21 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.59907244 |
| 22 | Spliceosome_Homo sapiens_hsa03040 | 1.58271566 |
| 23 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.56233527 |
| 24 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.50883871 |
| 25 | Osteoclast differentiation_Homo sapiens_hsa04380 | 1.50529914 |
| 26 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.42979541 |
| 27 | Homologous recombination_Homo sapiens_hsa03440 | 1.41925845 |
| 28 | Shigellosis_Homo sapiens_hsa05131 | 1.41802568 |
| 29 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.41044435 |
| 30 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.35320643 |
| 31 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.30418971 |
| 32 | Platelet activation_Homo sapiens_hsa04611 | 1.19450005 |
| 33 | Viral myocarditis_Homo sapiens_hsa05416 | 1.16949859 |
| 34 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.10176898 |
| 35 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.09991989 |
| 36 | Proteasome_Homo sapiens_hsa03050 | 1.09748268 |
| 37 | Hepatitis B_Homo sapiens_hsa05161 | 1.08490538 |
| 38 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.06087147 |
| 39 | Influenza A_Homo sapiens_hsa05164 | 1.01526422 |
| 40 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.99603925 |
| 41 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.99560399 |
| 42 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.99044167 |
| 43 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.98525539 |
| 44 | RNA degradation_Homo sapiens_hsa03018 | 0.97343741 |
| 45 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.96756942 |
| 46 | RNA polymerase_Homo sapiens_hsa03020 | 0.94418831 |
| 47 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.93331996 |
| 48 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.93087486 |
| 49 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.92824572 |
| 50 | HTLV-I infection_Homo sapiens_hsa05166 | 0.90230731 |
| 51 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.90135382 |
| 52 | Apoptosis_Homo sapiens_hsa04210 | 0.89759058 |
| 53 | Phagosome_Homo sapiens_hsa04145 | 0.88455909 |
| 54 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.87244441 |
| 55 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.86513160 |
| 56 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.83844373 |
| 57 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.83145539 |
| 58 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.83124406 |
| 59 | Legionellosis_Homo sapiens_hsa05134 | 0.82994635 |
| 60 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.77143844 |
| 61 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.76857272 |
| 62 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.76173441 |
| 63 | Malaria_Homo sapiens_hsa05144 | 0.76078018 |
| 64 | Cell cycle_Homo sapiens_hsa04110 | 0.74597463 |
| 65 | Colorectal cancer_Homo sapiens_hsa05210 | 0.72864913 |
| 66 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.71753167 |
| 67 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.70892099 |
| 68 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.70482866 |
| 69 | Asthma_Homo sapiens_hsa05310 | 0.68675650 |
| 70 | Endocytosis_Homo sapiens_hsa04144 | 0.68190154 |
| 71 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.67995070 |
| 72 | Other glycan degradation_Homo sapiens_hsa00511 | 0.66966427 |
| 73 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.66902684 |
| 74 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.66657494 |
| 75 | RNA transport_Homo sapiens_hsa03013 | 0.66373022 |
| 76 | Basal transcription factors_Homo sapiens_hsa03022 | 0.62840338 |
| 77 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.62183839 |
| 78 | Salmonella infection_Homo sapiens_hsa05132 | 0.61939235 |
| 79 | Pertussis_Homo sapiens_hsa05133 | 0.59732997 |
| 80 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.59145857 |
| 81 | Tuberculosis_Homo sapiens_hsa05152 | 0.59082028 |
| 82 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.56958689 |
| 83 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.56954941 |
| 84 | Sulfur relay system_Homo sapiens_hsa04122 | 0.56627494 |
| 85 | Hepatitis C_Homo sapiens_hsa05160 | 0.55565190 |
| 86 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.55053114 |
| 87 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.54522584 |
| 88 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.53686923 |
| 89 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.53491250 |
| 90 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.53273402 |
| 91 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.52211558 |
| 92 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.50716957 |
| 93 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.49480669 |
| 94 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.49438881 |
| 95 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.49390406 |
| 96 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.49364772 |
| 97 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.48643327 |
| 98 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.48449600 |
| 99 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.48290041 |
| 100 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.47831492 |
| 101 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.47764726 |
| 102 | Thyroid cancer_Homo sapiens_hsa05216 | 0.47423717 |
| 103 | Endometrial cancer_Homo sapiens_hsa05213 | 0.46458650 |
| 104 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.45694156 |
| 105 | Protein export_Homo sapiens_hsa03060 | 0.44236192 |
| 106 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.43817876 |
| 107 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.43566221 |
| 108 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.41917224 |
| 109 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.41044967 |
| 110 | Insulin resistance_Homo sapiens_hsa04931 | 0.38456751 |
| 111 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.38192877 |
| 112 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.37638039 |
| 113 | Purine metabolism_Homo sapiens_hsa00230 | 0.36888385 |
| 114 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.36839385 |
| 115 | Lysosome_Homo sapiens_hsa04142 | 0.36464461 |
| 116 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.35836982 |
| 117 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.35596132 |
| 118 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.34565176 |
| 119 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.34321714 |
| 120 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.34302598 |
| 121 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.33920666 |
| 122 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.33063645 |
| 123 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.32303010 |
| 124 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.32187849 |
| 125 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.31628179 |
| 126 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.31270856 |
| 127 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.30629509 |
| 128 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.29705540 |
| 129 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.26859985 |
| 130 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.26123806 |
| 131 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.25755532 |
| 132 | Prostate cancer_Homo sapiens_hsa05215 | 0.25444925 |
| 133 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.24144744 |
| 134 | Long-term potentiation_Homo sapiens_hsa04720 | 0.22589562 |

