

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | central nervous system myelination (GO:0022010) | 6.62604663 |
| 2 | axon ensheathment in central nervous system (GO:0032291) | 6.62604663 |
| 3 | fatty acid elongation (GO:0030497) | 4.93571367 |
| 4 | neuron cell-cell adhesion (GO:0007158) | 4.13576161 |
| 5 | nerve growth factor signaling pathway (GO:0038180) | 4.03304714 |
| 6 | myelination (GO:0042552) | 3.98297486 |
| 7 | axon ensheathment (GO:0008366) | 3.94642919 |
| 8 | ensheathment of neurons (GO:0007272) | 3.94642919 |
| 9 | negative regulation of neurotransmitter transport (GO:0051589) | 3.92800281 |
| 10 | long-chain fatty acid biosynthetic process (GO:0042759) | 3.74547185 |
| 11 | neuron remodeling (GO:0016322) | 3.72940525 |
| 12 | establishment of mitochondrion localization (GO:0051654) | 3.64223384 |
| 13 | postsynaptic membrane organization (GO:0001941) | 3.63380032 |
| 14 | negative regulation of neurotransmitter secretion (GO:0046929) | 3.59656385 |
| 15 | response to methylmercury (GO:0051597) | 3.56805207 |
| 16 | presynaptic membrane assembly (GO:0097105) | 3.50840076 |
| 17 | presynaptic membrane organization (GO:0097090) | 3.40336552 |
| 18 | neuron recognition (GO:0008038) | 3.39597762 |
| 19 | cholesterol biosynthetic process (GO:0006695) | 3.37896097 |
| 20 | glycerophospholipid catabolic process (GO:0046475) | 3.36094460 |
| 21 | dendrite morphogenesis (GO:0048813) | 3.28352354 |
| 22 | L-amino acid import (GO:0043092) | 3.24911457 |
| 23 | neuronal ion channel clustering (GO:0045161) | 3.23241513 |
| 24 | negative regulation of protein localization to cell surface (GO:2000009) | 3.20663093 |
| 25 | regulation of collateral sprouting (GO:0048670) | 3.19992664 |
| 26 | dendritic spine morphogenesis (GO:0060997) | 3.16197707 |
| 27 | apical protein localization (GO:0045176) | 3.11887302 |
| 28 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.10645161 |
| 29 | limb bud formation (GO:0060174) | 3.08326313 |
| 30 | transmission of nerve impulse (GO:0019226) | 3.08129050 |
| 31 | import into cell (GO:0098657) | 3.07338171 |
| 32 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.07142729 |
| 33 | establishment of nucleus localization (GO:0040023) | 3.05469370 |
| 34 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.02276748 |
| 35 | axonal fasciculation (GO:0007413) | 2.94568400 |
| 36 | synaptic vesicle maturation (GO:0016188) | 2.94357729 |
| 37 | sterol biosynthetic process (GO:0016126) | 2.93897224 |
| 38 | asymmetric protein localization (GO:0008105) | 2.92161698 |
| 39 | neurotransmitter catabolic process (GO:0042135) | 2.87780745 |
| 40 | cerebellar granule cell differentiation (GO:0021707) | 2.85229926 |
| 41 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.84697783 |
| 42 | macroautophagy (GO:0016236) | 2.84614967 |
| 43 | long-chain fatty-acyl-CoA biosynthetic process (GO:0035338) | 2.79424617 |
| 44 | cell migration in hindbrain (GO:0021535) | 2.78042989 |
| 45 | cyclic nucleotide catabolic process (GO:0009214) | 2.77571369 |
| 46 | mating behavior (GO:0007617) | 2.76658102 |
| 47 | vocalization behavior (GO:0071625) | 2.76553351 |
| 48 | negative regulation of axonogenesis (GO:0050771) | 2.74560480 |
| 49 | layer formation in cerebral cortex (GO:0021819) | 2.74217890 |
| 50 | isoprenoid biosynthetic process (GO:0008299) | 2.72991578 |
| 51 | regulation of fever generation (GO:0031620) | 2.72974342 |
| 52 | amino acid import (GO:0043090) | 2.71686646 |
| 53 | positive regulation of heat generation (GO:0031652) | 2.70528778 |
| 54 | negative regulation of axon extension (GO:0030517) | 2.69440523 |
| 55 | regulation of heat generation (GO:0031650) | 2.69384514 |
| 56 | long-chain fatty-acyl-CoA metabolic process (GO:0035336) | 2.68291792 |
| 57 | negative regulation of peptidyl-threonine phosphorylation (GO:0010801) | 2.68178726 |
| 58 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.65078135 |
| 59 | positive regulation of phosphoprotein phosphatase activity (GO:0032516) | 2.64554864 |
| 60 | oligodendrocyte differentiation (GO:0048709) | 2.64382450 |
| 61 | glycosphingolipid biosynthetic process (GO:0006688) | 2.59182233 |
| 62 | regulation of synapse structural plasticity (GO:0051823) | 2.58341544 |
| 63 | cAMP catabolic process (GO:0006198) | 2.54741774 |
| 64 | myelin maintenance (GO:0043217) | 2.54258916 |
| 65 | neuronal action potential propagation (GO:0019227) | 2.54258210 |
| 66 | regulation of lipoprotein metabolic process (GO:0050746) | 2.51124959 |
| 67 | fatty-acyl-CoA biosynthetic process (GO:0046949) | 2.50946317 |
| 68 | response to nerve growth factor (GO:1990089) | 2.49495597 |
| 69 | cellular response to nerve growth factor stimulus (GO:1990090) | 2.49495597 |
| 70 | positive regulation of synapse assembly (GO:0051965) | 2.49021758 |
| 71 | myelination in peripheral nervous system (GO:0022011) | 2.48167100 |
| 72 | peripheral nervous system axon ensheathment (GO:0032292) | 2.48167100 |
| 73 | photoreceptor cell differentiation (GO:0046530) | 2.47900486 |
| 74 | eye photoreceptor cell differentiation (GO:0001754) | 2.47900486 |
| 75 | substantia nigra development (GO:0021762) | 2.47436146 |
| 76 | membrane depolarization during action potential (GO:0086010) | 2.46092611 |
| 77 | magnesium ion transport (GO:0015693) | 2.42944838 |
| 78 | response to redox state (GO:0051775) | 2.42473054 |
| 79 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 2.41422497 |
| 80 | retina layer formation (GO:0010842) | 2.40969914 |
| 81 | axon extension (GO:0048675) | 2.40227338 |
| 82 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 2.39836790 |
| 83 | positive regulation of potassium ion transport (GO:0043268) | 2.39592082 |
| 84 | negative regulation of synaptic transmission (GO:0050805) | 2.39588802 |
| 85 | adult walking behavior (GO:0007628) | 2.39485207 |
| 86 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.39378762 |
| 87 | mitochondrion transport along microtubule (GO:0047497) | 2.39378762 |
| 88 | mechanosensory behavior (GO:0007638) | 2.39158623 |
| 89 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 2.38288631 |
| 90 | positive regulation of oligodendrocyte differentiation (GO:0048714) | 2.37698710 |
| 91 | negative regulation of systemic arterial blood pressure (GO:0003085) | 2.37664286 |
| 92 | very long-chain fatty acid metabolic process (GO:0000038) | 2.37309785 |
| 93 | dendrite development (GO:0016358) | 2.36644802 |
| 94 | short-term memory (GO:0007614) | 2.36438054 |
| 95 | astrocyte development (GO:0014002) | 2.35974457 |
| 96 | phospholipid translocation (GO:0045332) | 2.35962717 |
| 97 | lipid translocation (GO:0034204) | 2.35962717 |
| 98 | negative regulation of dendrite development (GO:2000171) | 2.35428762 |
| 99 | regulation of dendritic spine development (GO:0060998) | 2.34996242 |
| 100 | Rac protein signal transduction (GO:0016601) | 2.34439506 |
| 101 | response to lipoprotein particle (GO:0055094) | 2.34299774 |
| 102 | central nervous system neuron axonogenesis (GO:0021955) | 2.33998164 |
| 103 | auditory behavior (GO:0031223) | 2.33899523 |
| 104 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.33155178 |
| 105 | negative regulation of inclusion body assembly (GO:0090084) | 2.32662571 |
| 106 | fatty-acyl-CoA metabolic process (GO:0035337) | 2.32464534 |
| 107 | glutamate receptor signaling pathway (GO:0007215) | 2.32197323 |
| 108 | dopamine biosynthetic process (GO:0042416) | 2.31743241 |
| 109 | response to auditory stimulus (GO:0010996) | 2.31142686 |
| 110 | glutamate secretion (GO:0014047) | 2.30971245 |
| 111 | nucleobase catabolic process (GO:0046113) | 2.29612007 |
| 112 | nucleus localization (GO:0051647) | 2.29468409 |
| 113 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 2.28563968 |
| 114 | maternal behavior (GO:0042711) | 2.26756873 |
| 115 | ganglioside metabolic process (GO:0001573) | 2.26716842 |
| 116 | polyol transport (GO:0015791) | 2.26477336 |
| 117 | negative regulation of Rho protein signal transduction (GO:0035024) | 2.26357076 |
| 118 | regulation of axon guidance (GO:1902667) | 2.26350972 |
| 119 | positive regulation of neurological system process (GO:0031646) | 2.26287039 |
| 120 | synapse assembly (GO:0007416) | 2.26039914 |
| 121 | gamma-aminobutyric acid transport (GO:0015812) | 2.25808546 |
| 122 | synaptic transmission, glutamatergic (GO:0035249) | 2.25636885 |
| 123 | negative regulation of axon extension involved in axon guidance (GO:0048843) | 2.25594625 |
| 124 | protein targeting to lysosome (GO:0006622) | 2.24367874 |
| 125 | establishment of protein localization to vacuole (GO:0072666) | 2.24367874 |
| 126 | protein targeting to vacuole (GO:0006623) | 2.24367874 |
| 127 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.24336368 |
| 128 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 2.24172402 |
| 129 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.23954545 |
| 130 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.22881477 |
| 131 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.22738461 |
| 132 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.22603328 |
| 133 | startle response (GO:0001964) | 2.21739482 |
| 134 | protein localization to synapse (GO:0035418) | 2.21688007 |
| 135 | membrane assembly (GO:0071709) | 2.21515633 |
| 136 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.21307366 |
| 137 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 2.21055803 |
| 138 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.20224144 |
| 139 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.19739609 |
| 140 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 2.19621449 |
| 141 | peristalsis (GO:0030432) | 2.19184376 |
| 142 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.19012412 |
| 143 | protein localization to endosome (GO:0036010) | 2.18870484 |
| 144 | regulation of pigment cell differentiation (GO:0050932) | 2.18605634 |
| 145 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 2.18239450 |
| 146 | L-phenylalanine catabolic process (GO:0006559) | 2.18239450 |
| 147 | regulation of dopamine metabolic process (GO:0042053) | 2.17978282 |
| 148 | negative regulation of mast cell activation (GO:0033004) | 2.17488144 |
| 149 | positive regulation of dendritic spine development (GO:0060999) | 2.16613219 |
| 150 | proline transport (GO:0015824) | 2.15705837 |
| 151 | prostate gland growth (GO:0060736) | 2.15494344 |
| 152 | cell morphogenesis involved in neuron differentiation (GO:0048667) | 2.15062721 |
| 153 | cerebral cortex cell migration (GO:0021795) | 2.15014173 |
| 154 | cellular response to ethanol (GO:0071361) | 2.14088481 |
| 155 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.13564834 |
| 156 | neuronal action potential (GO:0019228) | 2.11412989 |
| 157 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.10580709 |
| 158 | retinal ganglion cell axon guidance (GO:0031290) | 2.09815816 |
| 159 | regulation of synapse assembly (GO:0051963) | 2.08517077 |
| 160 | C4-dicarboxylate transport (GO:0015740) | 2.06945956 |
| 161 | regulation of neurotransmitter secretion (GO:0046928) | 2.06616100 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.83722393 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.07075066 |
| 3 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.54306855 |
| 4 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.42478294 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.29993328 |
| 6 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.29962016 |
| 7 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.17081657 |
| 8 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.14340916 |
| 9 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 2.12441457 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.08004996 |
| 11 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.08004996 |
| 12 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.02968245 |
| 13 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.02251412 |
| 14 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.00793764 |
| 15 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.00322833 |
| 16 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.00092488 |
| 17 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.98541493 |
| 18 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.92962256 |
| 19 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.91877399 |
| 20 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.89515129 |
| 21 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.89255322 |
| 22 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.87958769 |
| 23 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.86285759 |
| 24 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.82993862 |
| 25 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.81609131 |
| 26 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.76846514 |
| 27 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.76170141 |
| 28 | VDR_22108803_ChIP-Seq_LS180_Human | 1.76126313 |
| 29 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.74546001 |
| 30 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.73230342 |
| 31 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.72706897 |
| 32 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.71390506 |
| 33 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.70270342 |
| 34 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.67908681 |
| 35 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.64697348 |
| 36 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.63372292 |
| 37 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.62848418 |
| 38 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.62716344 |
| 39 | P300_19829295_ChIP-Seq_ESCs_Human | 1.62627698 |
| 40 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.62385833 |
| 41 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.60170473 |
| 42 | FUS_26573619_Chip-Seq_HEK293_Human | 1.60037029 |
| 43 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.56745729 |
| 44 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.51088312 |
| 45 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.50357627 |
| 46 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.50357620 |
| 47 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.49611028 |
| 48 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.46732474 |
| 49 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.41555500 |
| 50 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.41399281 |
| 51 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.39321357 |
| 52 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.38135297 |
| 53 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.36164850 |
| 54 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.34720276 |
| 55 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.32645415 |
| 56 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.29020537 |
| 57 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.29020537 |
| 58 | STAT3_23295773_ChIP-Seq_U87_Human | 1.28506792 |
| 59 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.28467546 |
| 60 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.28097233 |
| 61 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.27936742 |
| 62 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.27710020 |
| 63 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.25975987 |
| 64 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.23551816 |
| 65 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.23403209 |
| 66 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.21878576 |
| 67 | CJUN_26792858_Chip-Seq_BT549_Human | 1.21087641 |
| 68 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.20549620 |
| 69 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.18494438 |
| 70 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.18484631 |
| 71 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.18484631 |
| 72 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.17164363 |
| 73 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.16987532 |
| 74 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.14921433 |
| 75 | AR_25329375_ChIP-Seq_VCAP_Human | 1.13933790 |
| 76 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.13608947 |
| 77 | TP53_16413492_ChIP-PET_HCT116_Human | 1.13426827 |
| 78 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.13193774 |
| 79 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.13168414 |
| 80 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.13019567 |
| 81 | * FOXM1_26456572_ChIP-Seq_MCF-7_Human | 1.12961193 |
| 82 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.12357062 |
| 83 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.12019495 |
| 84 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.11330832 |
| 85 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.11330832 |
| 86 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.10878764 |
| 87 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.09924623 |
| 88 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.09747680 |
| 89 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.09303333 |
| 90 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.09155685 |
| 91 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.08394028 |
| 92 | RXR_22108803_ChIP-Seq_LS180_Human | 1.08193836 |
| 93 | * TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.07210347 |
| 94 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.07099795 |
| 95 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.06801841 |
| 96 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.06799232 |
| 97 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.06674405 |
| 98 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.06431099 |
| 99 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.06057292 |
| 100 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.05538878 |
| 101 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.04857373 |
| 102 | JUN_21703547_ChIP-Seq_K562_Human | 1.04818467 |
| 103 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.03356169 |
| 104 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.01061051 |
| 105 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.00445741 |
| 106 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.00328284 |
| 107 | EWS_26573619_Chip-Seq_HEK293_Human | 0.99572024 |
| 108 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.98188789 |
| 109 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.98123602 |
| 110 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 0.96714302 |
| 111 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96635192 |
| 112 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.96599648 |
| 113 | KDM2B_26808549_Chip-Seq_REH_Human | 0.96473117 |
| 114 | * RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.95598703 |
| 115 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 0.95464363 |
| 116 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.95161581 |
| 117 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.94064655 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0000569_abnormal_digit_pigmentation | 4.82255564 |
| 2 | MP0003880_abnormal_central_pattern | 3.80924037 |
| 3 | MP0000920_abnormal_myelination | 2.93908776 |
| 4 | MP0004270_analgesia | 2.86732349 |
| 5 | MP0005423_abnormal_somatic_nervous | 2.70196760 |
| 6 | MP0004859_abnormal_synaptic_plasticity | 2.64663275 |
| 7 | MP0000778_abnormal_nervous_system | 2.63316794 |
| 8 | MP0001486_abnormal_startle_reflex | 2.51897720 |
| 9 | MP0004742_abnormal_vestibular_system | 2.38523489 |
| 10 | MP0003635_abnormal_synaptic_transmissio | 2.33836702 |
| 11 | MP0002064_seizures | 2.21119673 |
| 12 | MP0003690_abnormal_glial_cell | 2.15805908 |
| 13 | MP0002272_abnormal_nervous_system | 2.12343842 |
| 14 | MP0009745_abnormal_behavioral_response | 2.05040307 |
| 15 | MP0003329_amyloid_beta_deposits | 2.03302031 |
| 16 | MP0004885_abnormal_endolymph | 2.00685358 |
| 17 | MP0003634_abnormal_glial_cell | 1.91363757 |
| 18 | MP0002063_abnormal_learning/memory/cond | 1.88788855 |
| 19 | MP0002734_abnormal_mechanical_nocicepti | 1.86429755 |
| 20 | MP0005623_abnormal_meninges_morphology | 1.82786075 |
| 21 | MP0003195_calcinosis | 1.81984168 |
| 22 | MP0002572_abnormal_emotion/affect_behav | 1.76658633 |
| 23 | MP0005167_abnormal_blood-brain_barrier | 1.74311262 |
| 24 | MP0009046_muscle_twitch | 1.71050388 |
| 25 | MP0001905_abnormal_dopamine_level | 1.68365130 |
| 26 | MP0005410_abnormal_fertilization | 1.66460611 |
| 27 | MP0001440_abnormal_grooming_behavior | 1.62623277 |
| 28 | MP0001529_abnormal_vocalization | 1.59137461 |
| 29 | MP0009379_abnormal_foot_pigmentation | 1.56785454 |
| 30 | MP0006276_abnormal_autonomic_nervous | 1.54745779 |
| 31 | MP0000383_abnormal_hair_follicle | 1.53477092 |
| 32 | MP0002067_abnormal_sensory_capabilities | 1.49753077 |
| 33 | MP0005409_darkened_coat_color | 1.46453565 |
| 34 | MP0003950_abnormal_plasma_membrane | 1.46223719 |
| 35 | MP0003632_abnormal_nervous_system | 1.42248398 |
| 36 | MP0005171_absent_coat_pigmentation | 1.42238507 |
| 37 | MP0000955_abnormal_spinal_cord | 1.39399354 |
| 38 | MP0001299_abnormal_eye_distance/ | 1.38494350 |
| 39 | MP0005386_behavior/neurological_phenoty | 1.36027806 |
| 40 | MP0004924_abnormal_behavior | 1.36027806 |
| 41 | MP0000427_abnormal_hair_cycle | 1.35399271 |
| 42 | MP0002882_abnormal_neuron_morphology | 1.33526027 |
| 43 | MP0001968_abnormal_touch/_nociception | 1.32950161 |
| 44 | MP0003938_abnormal_ear_development | 1.32416453 |
| 45 | MP0009780_abnormal_chondrocyte_physiolo | 1.31399610 |
| 46 | MP0001177_atelectasis | 1.31030510 |
| 47 | MP0002139_abnormal_hepatobiliary_system | 1.29935226 |
| 48 | MP0002184_abnormal_innervation | 1.29567427 |
| 49 | MP0003136_yellow_coat_color | 1.27937870 |
| 50 | MP0005248_abnormal_Harderian_gland | 1.26162167 |
| 51 | MP0005551_abnormal_eye_electrophysiolog | 1.26058647 |
| 52 | MP0003879_abnormal_hair_cell | 1.23122426 |
| 53 | MP0000462_abnormal_digestive_system | 1.22666713 |
| 54 | MP0002066_abnormal_motor_capabilities/c | 1.21491788 |
| 55 | MP0003631_nervous_system_phenotype | 1.20508962 |
| 56 | MP0002733_abnormal_thermal_nociception | 1.20349171 |
| 57 | MP0002229_neurodegeneration | 1.19683360 |
| 58 | MP0002909_abnormal_adrenal_gland | 1.19551438 |
| 59 | MP0009250_abnormal_appendicular_skeleto | 1.19505748 |
| 60 | MP0005174_abnormal_tail_pigmentation | 1.18762707 |
| 61 | MP0009840_abnormal_foam_cell | 1.17724197 |
| 62 | MP0001970_abnormal_pain_threshold | 1.16357238 |
| 63 | MP0004272_abnormal_basement_membrane | 1.15831901 |
| 64 | MP0004134_abnormal_chest_morphology | 1.14168750 |
| 65 | MP0003385_abnormal_body_wall | 1.13743742 |
| 66 | MP0003633_abnormal_nervous_system | 1.12264685 |
| 67 | MP0001485_abnormal_pinna_reflex | 1.11198506 |
| 68 | MP0002152_abnormal_brain_morphology | 1.10839782 |
| 69 | MP0002557_abnormal_social/conspecific_i | 1.10771699 |
| 70 | MP0005646_abnormal_pituitary_gland | 1.09088838 |
| 71 | MP0005058_abnormal_lysosome_morphology | 1.08886229 |
| 72 | MP0003937_abnormal_limbs/digits/tail_de | 1.06806478 |
| 73 | MP0001188_hyperpigmentation | 1.06593604 |
| 74 | MP0010678_abnormal_skin_adnexa | 1.06194199 |
| 75 | MP0000604_amyloidosis | 1.04828818 |
| 76 | MP0002822_catalepsy | 1.03577205 |
| 77 | MP0005595_abnormal_vascular_smooth | 1.03215644 |
| 78 | MP0002102_abnormal_ear_morphology | 1.02176948 |
| 79 | MP0005253_abnormal_eye_physiology | 1.02131485 |
| 80 | MP0004142_abnormal_muscle_tone | 1.01754794 |
| 81 | MP0002752_abnormal_somatic_nervous | 1.00586032 |
| 82 | MP0001501_abnormal_sleep_pattern | 0.99391679 |
| 83 | MP0005645_abnormal_hypothalamus_physiol | 0.98042763 |
| 84 | MP0005195_abnormal_posterior_eye | 0.97183884 |
| 85 | MP0008569_lethality_at_weaning | 0.96080666 |
| 86 | MP0002736_abnormal_nociception_after | 0.95384092 |
| 87 | MP0000566_synostosis | 0.94273586 |
| 88 | MP0004811_abnormal_neuron_physiology | 0.93968182 |
| 89 | MP0000647_abnormal_sebaceous_gland | 0.92488912 |
| 90 | MP0010368_abnormal_lymphatic_system | 0.91179339 |
| 91 | MP0005377_hearing/vestibular/ear_phenot | 0.89039280 |
| 92 | MP0003878_abnormal_ear_physiology | 0.89039280 |
| 93 | MP0000747_muscle_weakness | 0.88933156 |
| 94 | MP0001340_abnormal_eyelid_morphology | 0.88537105 |
| 95 | MP0006072_abnormal_retinal_apoptosis | 0.87369367 |
| 96 | MP0008438_abnormal_cutaneous_collagen | 0.86663584 |
| 97 | MP0002295_abnormal_pulmonary_circulatio | 0.85918922 |
| 98 | MP0002735_abnormal_chemical_nociception | 0.85103516 |
| 99 | MP0001963_abnormal_hearing_physiology | 0.84796672 |
| 100 | MP0006054_spinal_hemorrhage | 0.84069765 |
| 101 | MP0003861_abnormal_nervous_system | 0.83196638 |
| 102 | MP0003755_abnormal_palate_morphology | 0.82015515 |
| 103 | MP0002638_abnormal_pupillary_reflex | 0.80253352 |
| 104 | MP0001502_abnormal_circadian_rhythm | 0.80132415 |
| 105 | MP0002332_abnormal_exercise_endurance | 0.79866536 |
| 106 | MP0002938_white_spotting | 0.78665323 |
| 107 | MP0003045_fibrosis | 0.77798204 |
| 108 | MP0004085_abnormal_heartbeat | 0.77463618 |
| 109 | MP0002837_dystrophic_cardiac_calcinosis | 0.75999176 |
| 110 | MP0004185_abnormal_adipocyte_glucose | 0.75618975 |
| 111 | MP0005187_abnormal_penis_morphology | 0.75119013 |
| 112 | MP0000013_abnormal_adipose_tissue | 0.74293337 |
| 113 | MP0002896_abnormal_bone_mineralization | 0.73329389 |
| 114 | MP0000631_abnormal_neuroendocrine_gland | 0.73178552 |
| 115 | MP0005367_renal/urinary_system_phenotyp | 0.72036413 |
| 116 | MP0000516_abnormal_urinary_system | 0.72036413 |
| 117 | MP0004215_abnormal_myocardial_fiber | 0.71878273 |
| 118 | MP0003122_maternal_imprinting | 0.71250371 |
| 119 | MP0000371_diluted_coat_color | 0.70440050 |
| 120 | MP0003787_abnormal_imprinting | 0.70390278 |
| 121 | MP0003698_abnormal_male_reproductive | 0.68912943 |
| 122 | MP0003137_abnormal_impulse_conducting | 0.68575787 |
| 123 | MP0003011_delayed_dark_adaptation | 0.68550809 |
| 124 | MP0002090_abnormal_vision | 0.68331030 |
| 125 | MP0000749_muscle_degeneration | 0.68318775 |
| 126 | MP0004043_abnormal_pH_regulation | 0.68093835 |
| 127 | MP0000026_abnormal_inner_ear | 0.67566401 |
| 128 | MP0000534_abnormal_ureter_morphology | 0.67335894 |
| 129 | MP0002168_other_aberrant_phenotype | 0.66898950 |
| 130 | MP0002133_abnormal_respiratory_system | 0.66654274 |
| 131 | MP0005388_respiratory_system_phenotype | 0.66654274 |
| 132 | MP0000015_abnormal_ear_pigmentation | 0.66292969 |
| 133 | MP0009384_cardiac_valve_regurgitation | 0.65620948 |
| 134 | MP0002249_abnormal_larynx_morphology | 0.65406268 |
| 135 | MP0001984_abnormal_olfaction | 0.65363170 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 5.38308468 |
| 2 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 5.38308468 |
| 3 | Neurofibrillary tangles (HP:0002185) | 5.01505884 |
| 4 | Abnormality of the corticospinal tract (HP:0002492) | 4.70532594 |
| 5 | Insidious onset (HP:0003587) | 4.43233066 |
| 6 | Termporal pattern (HP:0011008) | 4.43233066 |
| 7 | Cerebral inclusion bodies (HP:0100314) | 4.10035958 |
| 8 | Parakeratosis (HP:0001036) | 3.99173658 |
| 9 | Febrile seizures (HP:0002373) | 3.57013798 |
| 10 | Absent/shortened dynein arms (HP:0200106) | 3.53648126 |
| 11 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.53648126 |
| 12 | Sensory axonal neuropathy (HP:0003390) | 3.23356420 |
| 13 | Inappropriate behavior (HP:0000719) | 3.20996242 |
| 14 | Disinhibition (HP:0000734) | 3.10379480 |
| 15 | Focal motor seizures (HP:0011153) | 3.00369019 |
| 16 | Onion bulb formation (HP:0003383) | 2.98091461 |
| 17 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.96333724 |
| 18 | Peripheral hypomyelination (HP:0007182) | 2.92801099 |
| 19 | Spastic gait (HP:0002064) | 2.91805806 |
| 20 | Ankle clonus (HP:0011448) | 2.88827899 |
| 21 | Myokymia (HP:0002411) | 2.78823260 |
| 22 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.75745667 |
| 23 | Abnormal ciliary motility (HP:0012262) | 2.67183176 |
| 24 | Focal seizures (HP:0007359) | 2.64157259 |
| 25 | Dysmetria (HP:0001310) | 2.63634925 |
| 26 | Supranuclear gaze palsy (HP:0000605) | 2.57381288 |
| 27 | Pheochromocytoma (HP:0002666) | 2.54710641 |
| 28 | Drooling (HP:0002307) | 2.54243847 |
| 29 | Excessive salivation (HP:0003781) | 2.54243847 |
| 30 | Progressive cerebellar ataxia (HP:0002073) | 2.53144168 |
| 31 | Intention tremor (HP:0002080) | 2.50899894 |
| 32 | Retinal atrophy (HP:0001105) | 2.48426851 |
| 33 | Mutism (HP:0002300) | 2.47940335 |
| 34 | Atonic seizures (HP:0010819) | 2.41198323 |
| 35 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.38472226 |
| 36 | Coronal craniosynostosis (HP:0004440) | 2.34628155 |
| 37 | Limb dystonia (HP:0002451) | 2.31103101 |
| 38 | Abnormality of glycolipid metabolism (HP:0010969) | 2.28561794 |
| 39 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.28561794 |
| 40 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.28561794 |
| 41 | Segmental peripheral demyelination/remyelination (HP:0003481) | 2.27543142 |
| 42 | Fair hair (HP:0002286) | 2.26360871 |
| 43 | Broad-based gait (HP:0002136) | 2.25851769 |
| 44 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.24618003 |
| 45 | Aplasia of the phalanges of the hand (HP:0009802) | 2.24618003 |
| 46 | Aplasia involving bones of the extremities (HP:0009825) | 2.24618003 |
| 47 | Cerebral hemorrhage (HP:0001342) | 2.22467178 |
| 48 | Hyperventilation (HP:0002883) | 2.22379204 |
| 49 | Scanning speech (HP:0002168) | 2.16039923 |
| 50 | Anteriorly placed anus (HP:0001545) | 2.16020738 |
| 51 | Hypoplastic pelvis (HP:0008839) | 2.15586448 |
| 52 | Lower limb muscle weakness (HP:0007340) | 2.15375133 |
| 53 | Abnormality of the ischium (HP:0003174) | 2.15353926 |
| 54 | Action tremor (HP:0002345) | 2.13945993 |
| 55 | Protruding tongue (HP:0010808) | 2.11733507 |
| 56 | Buphthalmos (HP:0000557) | 2.09762941 |
| 57 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.07713253 |
| 58 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.07713253 |
| 59 | Tubular atrophy (HP:0000092) | 2.06102417 |
| 60 | Spastic tetraparesis (HP:0001285) | 2.04019235 |
| 61 | Neuroendocrine neoplasm (HP:0100634) | 2.01262334 |
| 62 | Alacrima (HP:0000522) | 2.00393317 |
| 63 | Hammertoe (HP:0001765) | 2.00334003 |
| 64 | Autoamputation (HP:0001218) | 2.00294651 |
| 65 | Urinary urgency (HP:0000012) | 1.99134492 |
| 66 | Clonus (HP:0002169) | 1.97350518 |
| 67 | Abnormal eating behavior (HP:0100738) | 1.96240495 |
| 68 | Retinal dysplasia (HP:0007973) | 1.93040952 |
| 69 | Pancreatic fibrosis (HP:0100732) | 1.92994860 |
| 70 | Neuronal loss in central nervous system (HP:0002529) | 1.92966564 |
| 71 | Epileptic encephalopathy (HP:0200134) | 1.92311392 |
| 72 | Hemiparesis (HP:0001269) | 1.91891789 |
| 73 | Hypophosphatemic rickets (HP:0004912) | 1.91172837 |
| 74 | Apathy (HP:0000741) | 1.91025902 |
| 75 | Abnormal auditory evoked potentials (HP:0006958) | 1.90022980 |
| 76 | Megalencephaly (HP:0001355) | 1.87581031 |
| 77 | Generalized hypopigmentation of hair (HP:0011358) | 1.86085562 |
| 78 | Decreased motor nerve conduction velocity (HP:0003431) | 1.85966805 |
| 79 | Hyperlipoproteinemia (HP:0010980) | 1.85471589 |
| 80 | Syncope (HP:0001279) | 1.85284681 |
| 81 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.82869563 |
| 82 | Ulnar claw (HP:0001178) | 1.82689263 |
| 83 | Generalized tonic-clonic seizures (HP:0002069) | 1.81954323 |
| 84 | Hypoplasia of the corpus callosum (HP:0002079) | 1.81186009 |
| 85 | Intellectual disability, moderate (HP:0002342) | 1.81167822 |
| 86 | True hermaphroditism (HP:0010459) | 1.80797941 |
| 87 | Dialeptic seizures (HP:0011146) | 1.80180844 |
| 88 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.79493068 |
| 89 | Global brain atrophy (HP:0002283) | 1.79174960 |
| 90 | Agnosia (HP:0010524) | 1.79060080 |
| 91 | Peripheral demyelination (HP:0011096) | 1.78901814 |
| 92 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.78733981 |
| 93 | Paraplegia (HP:0010550) | 1.78090495 |
| 94 | Agitation (HP:0000713) | 1.76450516 |
| 95 | Genetic anticipation (HP:0003743) | 1.76371425 |
| 96 | Type II lissencephaly (HP:0007260) | 1.75187046 |
| 97 | Humeroradial synostosis (HP:0003041) | 1.74657340 |
| 98 | Synostosis involving the elbow (HP:0003938) | 1.74657340 |
| 99 | Decreased lacrimation (HP:0000633) | 1.74529255 |
| 100 | Infantile muscular hypotonia (HP:0008947) | 1.74366111 |
| 101 | Fetal akinesia sequence (HP:0001989) | 1.74108358 |
| 102 | Spastic paraplegia (HP:0001258) | 1.74091242 |
| 103 | Abnormality of salivation (HP:0100755) | 1.74026236 |
| 104 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.73947010 |
| 105 | Hypoplasia of the brainstem (HP:0002365) | 1.73947010 |
| 106 | Abnormality of glycolysis (HP:0004366) | 1.73935934 |
| 107 | Increased serum pyruvate (HP:0003542) | 1.73935934 |
| 108 | Postural instability (HP:0002172) | 1.73823713 |
| 109 | Cutaneous finger syndactyly (HP:0010554) | 1.73669317 |
| 110 | Diminished motivation (HP:0000745) | 1.73307595 |
| 111 | Akinesia (HP:0002304) | 1.72991395 |
| 112 | Dysdiadochokinesis (HP:0002075) | 1.72559347 |
| 113 | Truncal ataxia (HP:0002078) | 1.72290469 |
| 114 | Steppage gait (HP:0003376) | 1.71716021 |
| 115 | Generalized myoclonic seizures (HP:0002123) | 1.71267908 |
| 116 | Pachygyria (HP:0001302) | 1.70774725 |
| 117 | Tubulointerstitial abnormality (HP:0001969) | 1.70591934 |
| 118 | Spastic tetraplegia (HP:0002510) | 1.70095796 |
| 119 | Myelomeningocele (HP:0002475) | 1.69853938 |
| 120 | Cortical dysplasia (HP:0002539) | 1.69573115 |
| 121 | Thickened helices (HP:0000391) | 1.69290524 |
| 122 | Absent speech (HP:0001344) | 1.68222227 |
| 123 | Widely spaced teeth (HP:0000687) | 1.67723987 |
| 124 | Exotropia (HP:0000577) | 1.67645512 |
| 125 | Epileptiform EEG discharges (HP:0011182) | 1.67636102 |
| 126 | Albinism (HP:0001022) | 1.67493159 |
| 127 | Cubitus valgus (HP:0002967) | 1.67320275 |
| 128 | Poor speech (HP:0002465) | 1.67003411 |
| 129 | Gaze-evoked nystagmus (HP:0000640) | 1.66865132 |
| 130 | Axonal loss (HP:0003447) | 1.66501863 |
| 131 | Hypoplastic left heart (HP:0004383) | 1.66279420 |
| 132 | Absent septum pellucidum (HP:0001331) | 1.66103246 |
| 133 | Absence seizures (HP:0002121) | 1.65092303 |
| 134 | Distal sensory impairment (HP:0002936) | 1.63714098 |
| 135 | Polyphagia (HP:0002591) | 1.62623670 |
| 136 | Broad metatarsal (HP:0001783) | 1.60640796 |
| 137 | Tubulointerstitial nephritis (HP:0001970) | 1.60615768 |
| 138 | Hyperthyroidism (HP:0000836) | 1.60612395 |
| 139 | Deep venous thrombosis (HP:0002625) | 1.59916884 |
| 140 | Cerebellar dysplasia (HP:0007033) | 1.59024105 |
| 141 | Abnormality of incisor morphology (HP:0011063) | 1.58686678 |
| 142 | Pancreatic cysts (HP:0001737) | 1.56575850 |
| 143 | Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204) | 1.56442267 |
| 144 | Nephronophthisis (HP:0000090) | 1.54731985 |
| 145 | Bundle branch block (HP:0011710) | 1.54642920 |
| 146 | Prolonged QT interval (HP:0001657) | 1.54306915 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | STK39 | 4.33640283 |
| 2 | CASK | 3.54664398 |
| 3 | MARK1 | 3.38968545 |
| 4 | OXSR1 | 2.56282368 |
| 5 | PNCK | 2.21331828 |
| 6 | PKN1 | 2.19691835 |
| 7 | WNK4 | 2.16891791 |
| 8 | MAP3K4 | 2.13651888 |
| 9 | MAPKAPK5 | 2.03797935 |
| 10 | ACVR1B | 2.02101379 |
| 11 | CAMKK2 | 2.00737589 |
| 12 | FGFR2 | 1.95207234 |
| 13 | MAPK13 | 1.83306947 |
| 14 | NTRK2 | 1.79783223 |
| 15 | BMPR1B | 1.79670228 |
| 16 | LATS1 | 1.77126310 |
| 17 | STK38L | 1.74697530 |
| 18 | BCR | 1.72548853 |
| 19 | MAP2K7 | 1.66390872 |
| 20 | PINK1 | 1.64045435 |
| 21 | EPHB1 | 1.56168649 |
| 22 | WNK1 | 1.55785476 |
| 23 | IRAK3 | 1.55225593 |
| 24 | CSNK1G3 | 1.54846601 |
| 25 | PAK6 | 1.54279607 |
| 26 | CSNK1A1L | 1.53724915 |
| 27 | CSNK1G2 | 1.46123639 |
| 28 | PAK3 | 1.45060843 |
| 29 | DYRK2 | 1.39462735 |
| 30 | CSNK1G1 | 1.39074798 |
| 31 | DAPK2 | 1.37086014 |
| 32 | NTRK1 | 1.36245638 |
| 33 | FGR | 1.35497871 |
| 34 | ADRBK2 | 1.35420964 |
| 35 | MAP2K4 | 1.34470755 |
| 36 | UHMK1 | 1.32570896 |
| 37 | SGK223 | 1.32477745 |
| 38 | SGK494 | 1.32477745 |
| 39 | LATS2 | 1.25230653 |
| 40 | EPHA4 | 1.24996090 |
| 41 | MOS | 1.24935031 |
| 42 | TYRO3 | 1.24039654 |
| 43 | SGK2 | 1.22714749 |
| 44 | EPHA3 | 1.20050171 |
| 45 | PHKG1 | 1.19529813 |
| 46 | PHKG2 | 1.19529813 |
| 47 | CAMK1G | 1.18810600 |
| 48 | MET | 1.17042785 |
| 49 | KSR1 | 1.16701245 |
| 50 | CAMK2B | 1.15523366 |
| 51 | FRK | 1.09353110 |
| 52 | TGFBR2 | 1.08900011 |
| 53 | CAMK2A | 1.07199800 |
| 54 | PLK2 | 1.02789247 |
| 55 | CDK5 | 1.02752822 |
| 56 | PRKCE | 1.02121259 |
| 57 | ERBB4 | 1.01785984 |
| 58 | NTRK3 | 0.99843127 |
| 59 | MINK1 | 0.97325383 |
| 60 | GRK5 | 0.92389192 |
| 61 | MAP3K12 | 0.92364956 |
| 62 | ROCK2 | 0.92339392 |
| 63 | EPHB2 | 0.91605404 |
| 64 | DYRK1A | 0.91325362 |
| 65 | PRPF4B | 0.90446000 |
| 66 | LIMK1 | 0.87192708 |
| 67 | DDR2 | 0.86243457 |
| 68 | NEK9 | 0.85062253 |
| 69 | SGK3 | 0.84652947 |
| 70 | GRK7 | 0.84346107 |
| 71 | ERBB3 | 0.81957578 |
| 72 | CAMKK1 | 0.79383140 |
| 73 | CAMK2G | 0.78781972 |
| 74 | TNIK | 0.75791281 |
| 75 | MKNK1 | 0.73093115 |
| 76 | MUSK | 0.73007746 |
| 77 | MARK2 | 0.72273334 |
| 78 | CDK14 | 0.72052936 |
| 79 | CAMK2D | 0.71453088 |
| 80 | MAP3K2 | 0.71021537 |
| 81 | WEE1 | 0.70197048 |
| 82 | GSK3A | 0.70044065 |
| 83 | IRAK1 | 0.69783426 |
| 84 | BMPR2 | 0.69631959 |
| 85 | MKNK2 | 0.69244156 |
| 86 | PDK4 | 0.68645525 |
| 87 | PDK3 | 0.68645525 |
| 88 | DYRK3 | 0.68196871 |
| 89 | NEK6 | 0.65772001 |
| 90 | PDGFRB | 0.64851162 |
| 91 | STK11 | 0.64717270 |
| 92 | CDK15 | 0.63119811 |
| 93 | CDK3 | 0.63031379 |
| 94 | PRKCG | 0.61860679 |
| 95 | AKT3 | 0.60120891 |
| 96 | ROCK1 | 0.59983602 |
| 97 | ICK | 0.59575003 |
| 98 | BRD4 | 0.59315792 |
| 99 | DMPK | 0.58981950 |
| 100 | INSRR | 0.58771365 |
| 101 | CDK18 | 0.58601349 |
| 102 | PDGFRA | 0.58379727 |
| 103 | PAK2 | 0.58282468 |
| 104 | RPS6KA5 | 0.57989377 |
| 105 | PTK2B | 0.57581005 |
| 106 | MAP3K9 | 0.57351644 |
| 107 | ADRBK1 | 0.57285608 |
| 108 | PRKD1 | 0.55357022 |
| 109 | STK3 | 0.54672984 |
| 110 | FER | 0.53226203 |
| 111 | WNK3 | 0.52686516 |
| 112 | PDK2 | 0.52337421 |
| 113 | CAMK4 | 0.52172997 |
| 114 | RET | 0.51673634 |
| 115 | CSNK1D | 0.51184308 |
| 116 | PRKCQ | 0.51050403 |
| 117 | CDK11A | 0.51041516 |
| 118 | MAPK15 | 0.50303313 |
| 119 | RIPK1 | 0.50153277 |
| 120 | PRKCH | 0.50119242 |
| 121 | CAMK1D | 0.48635449 |
| 122 | PRKG1 | 0.47570056 |
| 123 | PRKCZ | 0.46709290 |
| 124 | TRIM28 | 0.45134984 |
| 125 | PRKD3 | 0.44386680 |
| 126 | STK38 | 0.43564098 |
| 127 | SGK1 | 0.42963443 |
| 128 | MAPK7 | 0.41372195 |
| 129 | GRK1 | 0.41304912 |
| 130 | BLK | 0.39072889 |
| 131 | ABL2 | 0.37584926 |
| 132 | MAPK10 | 0.36562744 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 3.53165545 |
| 2 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.03540507 |
| 3 | Steroid biosynthesis_Homo sapiens_hsa00100 | 2.85415624 |
| 4 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.83495593 |
| 5 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.42574537 |
| 6 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.22470401 |
| 7 | Ether lipid metabolism_Homo sapiens_hsa00565 | 2.06273897 |
| 8 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.96747577 |
| 9 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.93151308 |
| 10 | Axon guidance_Homo sapiens_hsa04360 | 1.89354488 |
| 11 | Nicotine addiction_Homo sapiens_hsa05033 | 1.84386331 |
| 12 | GABAergic synapse_Homo sapiens_hsa04727 | 1.81743385 |
| 13 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.70170424 |
| 14 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.69473927 |
| 15 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.65306450 |
| 16 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.57865536 |
| 17 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.54012538 |
| 18 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.46213202 |
| 19 | Long-term depression_Homo sapiens_hsa04730 | 1.34729874 |
| 20 | Lysosome_Homo sapiens_hsa04142 | 1.34626230 |
| 21 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.34138325 |
| 22 | Morphine addiction_Homo sapiens_hsa05032 | 1.30231681 |
| 23 | Cocaine addiction_Homo sapiens_hsa05030 | 1.28968948 |
| 24 | Circadian rhythm_Homo sapiens_hsa04710 | 1.22012032 |
| 25 | Circadian entrainment_Homo sapiens_hsa04713 | 1.20296364 |
| 26 | Renal cell carcinoma_Homo sapiens_hsa05211 | 1.19552774 |
| 27 | Renin secretion_Homo sapiens_hsa04924 | 1.17649752 |
| 28 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.13875191 |
| 29 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.09505587 |
| 30 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.05918227 |
| 31 | ABC transporters_Homo sapiens_hsa02010 | 1.05417606 |
| 32 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.04523667 |
| 33 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.04392120 |
| 34 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.02598081 |
| 35 | Long-term potentiation_Homo sapiens_hsa04720 | 1.00791278 |
| 36 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.99915267 |
| 37 | Histidine metabolism_Homo sapiens_hsa00340 | 0.98694499 |
| 38 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.95144413 |
| 39 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.93383782 |
| 40 | Taste transduction_Homo sapiens_hsa04742 | 0.92095561 |
| 41 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.90004404 |
| 42 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.89169675 |
| 43 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.88352359 |
| 44 | Salivary secretion_Homo sapiens_hsa04970 | 0.87384911 |
| 45 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.87100622 |
| 46 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.86931405 |
| 47 | Phototransduction_Homo sapiens_hsa04744 | 0.86233594 |
| 48 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.85960315 |
| 49 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.83577254 |
| 50 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.81498982 |
| 51 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.80544825 |
| 52 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.80505236 |
| 53 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.80464908 |
| 54 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.80023914 |
| 55 | Gap junction_Homo sapiens_hsa04540 | 0.79712652 |
| 56 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.78878332 |
| 57 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.77227232 |
| 58 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.76758962 |
| 59 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.76260858 |
| 60 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.76085946 |
| 61 | Alzheimers disease_Homo sapiens_hsa05010 | 0.75465654 |
| 62 | Tight junction_Homo sapiens_hsa04530 | 0.74940535 |
| 63 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.74417692 |
| 64 | Insulin secretion_Homo sapiens_hsa04911 | 0.74339805 |
| 65 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.73623383 |
| 66 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.73254842 |
| 67 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.72904269 |
| 68 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.72668473 |
| 69 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.72594041 |
| 70 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.72073800 |
| 71 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.72041464 |
| 72 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.71185395 |
| 73 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.69840667 |
| 74 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.69475376 |
| 75 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.69310144 |
| 76 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.67825242 |
| 77 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.67567096 |
| 78 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.67024391 |
| 79 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.66341102 |
| 80 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.65836965 |
| 81 | Pertussis_Homo sapiens_hsa05133 | 0.64726097 |
| 82 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.64662358 |
| 83 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.64449072 |
| 84 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.64351582 |
| 85 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.63582260 |
| 86 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.62782322 |
| 87 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.62145787 |
| 88 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.62058372 |
| 89 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.61491214 |
| 90 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.61487046 |
| 91 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.60451354 |
| 92 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.60103310 |
| 93 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.59989180 |
| 94 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.59752694 |
| 95 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.59388798 |
| 96 | Olfactory transduction_Homo sapiens_hsa04740 | 0.59218645 |
| 97 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.59125044 |
| 98 | Parkinsons disease_Homo sapiens_hsa05012 | 0.58924507 |
| 99 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.58500833 |
| 100 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.58331229 |
| 101 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.57982525 |
| 102 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.57643157 |
| 103 | Salmonella infection_Homo sapiens_hsa05132 | 0.57628614 |
| 104 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.57333178 |
| 105 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.57313027 |
| 106 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.56643172 |
| 107 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.56229944 |
| 108 | Melanogenesis_Homo sapiens_hsa04916 | 0.56134641 |
| 109 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.55624647 |
| 110 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.55616944 |
| 111 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.54026740 |
| 112 | Prion diseases_Homo sapiens_hsa05020 | 0.53609645 |
| 113 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.53225598 |
| 114 | Amoebiasis_Homo sapiens_hsa05146 | 0.51539002 |
| 115 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.50647067 |
| 116 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.49628181 |
| 117 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.48971015 |
| 118 | Mineral absorption_Homo sapiens_hsa04978 | 0.48970100 |
| 119 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.48769462 |
| 120 | Bile secretion_Homo sapiens_hsa04976 | 0.47915008 |
| 121 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.47769160 |
| 122 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.47319053 |
| 123 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.47203860 |
| 124 | Protein export_Homo sapiens_hsa03060 | 0.46974002 |
| 125 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.46858125 |
| 126 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.46668860 |
| 127 | Retinol metabolism_Homo sapiens_hsa00830 | 0.46518697 |
| 128 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.46407300 |
| 129 | Melanoma_Homo sapiens_hsa05218 | 0.45226351 |
| 130 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.45190052 |
| 131 | Glioma_Homo sapiens_hsa05214 | 0.44996446 |

