TBC1D15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ras-like proteins in brain-GTPase activating protein superfamily that share a conserved Tre-2/Bub2/Cdc16 domain. The encoded protein interacts with Ras-like protein in brain 5A and may function as a regulator of intracellular trafficking. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.80966855
2protein K11-linked deubiquitination (GO:0035871)4.65705486
3piRNA metabolic process (GO:0034587)4.55661644
4attachment of spindle microtubules to kinetochore (GO:0008608)4.52938947
5positive regulation of vasculogenesis (GO:2001214)4.38097285
6activated T cell proliferation (GO:0050798)4.27696410
7regulation of RIG-I signaling pathway (GO:0039535)4.26688712
8negative regulation of neurotransmitter transport (GO:0051589)4.24293826
9metaphase plate congression (GO:0051310)4.13252995
10meiotic chromosome segregation (GO:0045132)4.12411597
11negative regulation of neurotransmitter secretion (GO:0046929)3.99980606
12negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.88786834
13establishment of chromosome localization (GO:0051303)3.86014621
14regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.80989818
15meiotic cell cycle (GO:0051321)3.79934697
16maturation of 5.8S rRNA (GO:0000460)3.79891790
17negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.78796358
18positive regulation of granulocyte differentiation (GO:0030854)3.78349959
19synapsis (GO:0007129)3.78031852
20DNA double-strand break processing (GO:0000729)3.72746036
21nerve growth factor signaling pathway (GO:0038180)3.70068780
22female gamete generation (GO:0007292)3.69860474
23regulation of female gonad development (GO:2000194)3.58349454
24cell wall macromolecule catabolic process (GO:0016998)3.57761252
25mitotic chromosome condensation (GO:0007076)3.54153013
26positive regulation of immune response to tumor cell (GO:0002839)3.52975150
27regulation of immune response to tumor cell (GO:0002837)3.52975150
28regulation of response to tumor cell (GO:0002834)3.52975150
29positive regulation of response to tumor cell (GO:0002836)3.52975150
30protein neddylation (GO:0045116)3.48772977
31regulation of centriole replication (GO:0046599)3.48396401
32regulation of spindle organization (GO:0090224)3.47452673
33regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.46684152
34protein localization to kinetochore (GO:0034501)3.40462661
35oocyte maturation (GO:0001556)3.39962814
36negative regulation of meiosis (GO:0045835)3.39472045
37neural tube formation (GO:0001841)3.39134886
38regulation of vasculogenesis (GO:2001212)3.34687367
39CENP-A containing nucleosome assembly (GO:0034080)3.33708671
40protein K63-linked deubiquitination (GO:0070536)3.29547010
41definitive hemopoiesis (GO:0060216)3.26759614
42histone H2A monoubiquitination (GO:0035518)3.24739931
43regulation of exit from mitosis (GO:0007096)3.23096072
44male meiosis (GO:0007140)3.22952349
45regulation of mitotic spindle organization (GO:0060236)3.20929946
46negative regulation of DNA-dependent DNA replication (GO:2000104)3.19854170
47regulation of retinoic acid receptor signaling pathway (GO:0048385)3.17761998
48mitotic nuclear envelope disassembly (GO:0007077)3.15322043
49centriole assembly (GO:0098534)3.15072879
50chromatin remodeling at centromere (GO:0031055)3.14394279
51DNA methylation involved in gamete generation (GO:0043046)3.12636819
52monoubiquitinated protein deubiquitination (GO:0035520)3.12041255
53protein localization to chromosome, centromeric region (GO:0071459)3.11148361
54regulation of meiosis I (GO:0060631)3.10917646
55regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.05637781
56nuclear pore complex assembly (GO:0051292)3.04517789
57immunoglobulin mediated immune response (GO:0016064)3.03603057
58regulation of meiosis (GO:0040020)3.00566592
59positive regulation of chromosome segregation (GO:0051984)2.99522369
60histone H2A ubiquitination (GO:0033522)2.99330271
61dopamine transport (GO:0015872)2.97984213
62mitotic sister chromatid segregation (GO:0000070)2.97189822
63rRNA methylation (GO:0031167)2.96908720
64replication fork processing (GO:0031297)2.96078294
65nuclear pore organization (GO:0006999)2.95555528
66regulation of establishment of cell polarity (GO:2000114)2.93614738
67chromosome segregation (GO:0007059)2.92813541
68negative regulation of DNA-templated transcription, elongation (GO:0032785)2.92600806
69negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.92600806
70double-strand break repair via homologous recombination (GO:0000724)2.92442955
71regulation of histone H3-K27 methylation (GO:0061085)2.92203796
72regulation of DNA endoreduplication (GO:0032875)2.92106109
73recombinational repair (GO:0000725)2.91686181
74nuclear envelope disassembly (GO:0051081)2.89884355
75membrane disassembly (GO:0030397)2.89884355
76cell wall macromolecule metabolic process (GO:0044036)2.89014284
77prenylation (GO:0097354)2.88462472
78protein prenylation (GO:0018342)2.88462472
79DNA replication-independent nucleosome organization (GO:0034724)2.85600540
80DNA replication-independent nucleosome assembly (GO:0006336)2.85600540
81fucose catabolic process (GO:0019317)2.84767831
82L-fucose metabolic process (GO:0042354)2.84767831
83L-fucose catabolic process (GO:0042355)2.84767831
84protein localization to chromosome (GO:0034502)2.84656690
85resolution of meiotic recombination intermediates (GO:0000712)2.84037973
86reciprocal DNA recombination (GO:0035825)2.83520416
87reciprocal meiotic recombination (GO:0007131)2.83520416
88acrosome assembly (GO:0001675)2.83003995
89embryonic hemopoiesis (GO:0035162)2.81678799
90histone exchange (GO:0043486)2.80211951
91interkinetic nuclear migration (GO:0022027)2.80007786
92regulation of glucokinase activity (GO:0033131)2.78612651
93regulation of hexokinase activity (GO:1903299)2.78612651
94lactate metabolic process (GO:0006089)2.78211431
95RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77267209
96DNA replication checkpoint (GO:0000076)2.70892121
97negative regulation of translation, ncRNA-mediated (GO:0040033)2.70460264
98regulation of translation, ncRNA-mediated (GO:0045974)2.70460264
99negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.70460264
100rRNA catabolic process (GO:0016075)2.70272378
101regulation of hypersensitivity (GO:0002883)2.65947908
102spindle checkpoint (GO:0031577)2.62464270
103centriole replication (GO:0007099)2.61884002
104regulation of MHC class II biosynthetic process (GO:0045346)2.61836780
105intra-S DNA damage checkpoint (GO:0031573)2.61771019
106kinetochore organization (GO:0051383)2.60899220
107mitotic G2/M transition checkpoint (GO:0044818)2.60751981
108NIK/NF-kappaB signaling (GO:0038061)2.59160414
109Rap protein signal transduction (GO:0032486)2.59098550
110negative regulation of T-helper cell differentiation (GO:0045623)2.59015186
111negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.59015186
112intraciliary transport (GO:0042073)2.58595734
113negative regulation of DNA recombination (GO:0045910)2.57462832
114positive regulation of megakaryocyte differentiation (GO:0045654)2.57431513
115postreplication repair (GO:0006301)2.55119726
116positive regulation of defense response to virus by host (GO:0002230)2.53598978
117regulation of mRNA 3-end processing (GO:0031440)2.53583359
118necroptotic process (GO:0070266)2.53540037
119regulation of sister chromatid cohesion (GO:0007063)2.53390249
120DNA damage induced protein phosphorylation (GO:0006975)2.52495085
121adenosine metabolic process (GO:0046085)2.52445016
122regulation of chromosome segregation (GO:0051983)2.52410898
123positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.52198634
124mitochondrial calcium ion transport (GO:0006851)2.51175303
125establishment of protein localization to Golgi (GO:0072600)2.51158840
126signal peptide processing (GO:0006465)2.50617844
127glycerophospholipid catabolic process (GO:0046475)2.49936747
128regulation of activation of Janus kinase activity (GO:0010533)2.49890693
129B cell mediated immunity (GO:0019724)2.49230709
130folic acid-containing compound biosynthetic process (GO:0009396)2.48513831
131mismatch repair (GO:0006298)2.48131081
132kinetochore assembly (GO:0051382)2.47664003
133thrombin receptor signaling pathway (GO:0070493)2.47273100
134mitotic G2 DNA damage checkpoint (GO:0007095)2.46813616
135response to X-ray (GO:0010165)2.45014338
136DNA ligation (GO:0006266)2.44966030
137photoreceptor cell maintenance (GO:0045494)2.44725097
138regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.44623685
139positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.44623685
140negative regulation of thymocyte apoptotic process (GO:0070244)2.44098823
141detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44028595
142meiotic nuclear division (GO:0007126)2.43305996
143antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.43228029
144type B pancreatic cell development (GO:0003323)2.43012089
145centrosome organization (GO:0051297)2.42903232
146sister chromatid segregation (GO:0000819)2.42575123
147phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.42363523
148negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.41747941
149positive regulation of mitotic sister chromatid separation (GO:1901970)2.41434784
150positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.41434784
151positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.41434784
152positive regulation of Cdc42 GTPase activity (GO:0043089)2.41299581
153telomere maintenance via recombination (GO:0000722)2.40580635
154regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.40482260
155regulation of mitotic spindle checkpoint (GO:1903504)2.40482260
156regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.39577552
157protein K6-linked ubiquitination (GO:0085020)2.38926289
158L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.38460457
159mitotic spindle checkpoint (GO:0071174)2.37584642
160mitotic sister chromatid cohesion (GO:0007064)2.35529749
161regulation of double-strand break repair via homologous recombination (GO:0010569)2.34431808
162nuclear envelope organization (GO:0006998)2.32990932
163N-terminal protein amino acid acetylation (GO:0006474)2.32724310
164regulation of meiotic cell cycle (GO:0051445)2.32708302
165DNA damage response, signal transduction resulting in transcription (GO:0042772)2.32357646
166myoblast migration (GO:0051451)2.32132437
167sister chromatid cohesion (GO:0007062)2.30027625
168negative regulation of meiotic cell cycle (GO:0051447)2.28759613
169regulation of mononuclear cell migration (GO:0071675)2.28251037
170regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.27381847
171DNA synthesis involved in DNA repair (GO:0000731)2.27008791
172DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.25831817
173meiosis I (GO:0007127)2.23824398
174neutrophil activation involved in immune response (GO:0002283)2.23125259
175regulation of spindle checkpoint (GO:0090231)2.23022421
176gene silencing by RNA (GO:0031047)2.22733097
177regulation of mitotic metaphase/anaphase transition (GO:0030071)2.22498928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.63729960
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.46360567
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.27613964
4POU3F2_20337985_ChIP-ChIP_501MEL_Human3.22586232
5IRF8_21731497_ChIP-ChIP_J774_Mouse2.83468467
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.79772326
7AR_21909140_ChIP-Seq_LNCAP_Human2.60015763
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57550262
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.56977895
10EWS_26573619_Chip-Seq_HEK293_Human2.54994195
11IGF1R_20145208_ChIP-Seq_DFB_Human2.52371125
12KAP1_22055183_ChIP-Seq_ESCs_Mouse2.45874787
13* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.43968253
14* GABP_17652178_ChIP-ChIP_JURKAT_Human2.41103496
15TAF15_26573619_Chip-Seq_HEK293_Human2.39574821
16VDR_22108803_ChIP-Seq_LS180_Human2.37539675
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21727420
18* EST1_17652178_ChIP-ChIP_JURKAT_Human2.12696774
19FUS_26573619_Chip-Seq_HEK293_Human2.08343654
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07622844
21ZNF274_21170338_ChIP-Seq_K562_Hela2.07210004
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.00528628
23GBX2_23144817_ChIP-Seq_PC3_Human1.96880601
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95258762
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94027476
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87481931
27* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84863390
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80855909
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78869445
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78802722
31P300_19829295_ChIP-Seq_ESCs_Human1.77651822
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.76189433
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75756931
34* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.73437430
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.71847584
36VDR_23849224_ChIP-Seq_CD4+_Human1.67862556
37ER_23166858_ChIP-Seq_MCF-7_Human1.67089525
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66627842
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66117366
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.65959105
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65335442
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64456454
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61769148
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60390579
45* E2F1_21310950_ChIP-Seq_MCF-7_Human1.56442072
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55669612
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.54428658
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52843732
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.52634628
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.52610776
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52329666
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50426789
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.48898710
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.48336045
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.48308604
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47175249
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47042373
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46842591
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46197531
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46167723
61SPI1_23547873_ChIP-Seq_NB4_Human1.45440757
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.44419117
63* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.44029721
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43546577
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40530108
66TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39305377
67SMAD4_21799915_ChIP-Seq_A2780_Human1.39277171
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39096713
69BCAT_22108803_ChIP-Seq_LS180_Human1.39077424
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38934757
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38762431
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38617693
73* MYC_18555785_ChIP-Seq_MESCs_Mouse1.37703176
74* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37003828
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.36986117
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.36655777
77* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36576552
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36277079
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35480988
80DCP1A_22483619_ChIP-Seq_HELA_Human1.34534175
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.34408199
82* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32441740
83ELK1_19687146_ChIP-ChIP_HELA_Human1.32257818
84FOXP3_21729870_ChIP-Seq_TREG_Human1.31310790
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.30767056
86CBP_20019798_ChIP-Seq_JUKART_Human1.30434911
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30434911
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29487582
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.28532628
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28390849
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28178289
92STAT3_23295773_ChIP-Seq_U87_Human1.27598889
93CDX2_22108803_ChIP-Seq_LS180_Human1.26743131
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26630292
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26315736
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25978769
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25780878
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.25161124
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24076650
100MYB_26560356_Chip-Seq_TH2_Human1.23522801
101* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22970420
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22811737
103AR_25329375_ChIP-Seq_VCAP_Human1.22424079
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.22334197
105GATA1_22025678_ChIP-Seq_K562_Human1.21819702
106TCF4_22108803_ChIP-Seq_LS180_Human1.21365087
107P53_22387025_ChIP-Seq_ESCs_Mouse1.20603791
108* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20048124
109* GABP_19822575_ChIP-Seq_HepG2_Human1.20030108
110MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19938090
111MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19930425
112* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.18776356
113SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18666841
114IRF1_19129219_ChIP-ChIP_H3396_Human1.18212868
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18196711
116NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17659109
117TCF4_23295773_ChIP-Seq_U87_Human1.17586583
118TFEB_21752829_ChIP-Seq_HELA_Human1.17140286
119FLI1_27457419_Chip-Seq_LIVER_Mouse1.16252405
120* FLI1_21867929_ChIP-Seq_TH2_Mouse1.15909029
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15614990
122CMYC_18555785_Chip-Seq_ESCs_Mouse1.14721039
123SALL4_22934838_ChIP-ChIP_CD34+_Human1.12352605
124MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11981070
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10842887
126* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.10840255
127FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10671993
128MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09740130
129CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.09714544
130P300_18555785_Chip-Seq_ESCs_Mouse1.09636105
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09366479
132CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08619848
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07673363
134SCL_19346495_ChIP-Seq_HPC-7_Human1.07657219
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06842479
136HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06127038
137* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05468644
138STAT3_18555785_Chip-Seq_ESCs_Mouse1.05077469
139EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04507690
140NMYC_18555785_Chip-Seq_ESCs_Mouse1.04248985
141GATA3_26560356_Chip-Seq_TH2_Human1.03560171
142* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03419012
143NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03390651
144NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02989773
145NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02989773
146KDM5A_27292631_Chip-Seq_BREAST_Human1.02031588
147NANOG_19829295_ChIP-Seq_ESCs_Human1.01337759
148SOX2_19829295_ChIP-Seq_ESCs_Human1.01337759
149* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00956595
150PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00874776
151OCT4_18555785_Chip-Seq_ESCs_Mouse1.00811998
152MYC_18940864_ChIP-ChIP_HL60_Human1.00508557
153ELF1_17652178_ChIP-ChIP_JURKAT_Human1.00404627
154MYB_26560356_Chip-Seq_TH1_Human0.99262075
155STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.94865561
156FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94379537
157EGR1_19374776_ChIP-ChIP_THP-1_Human0.94161221
158GATA3_27048872_Chip-Seq_THYMUS_Human0.93010216
159DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92015075
160SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89442728
161* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88273283
162PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88197470
163CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87519484
164* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87451747
165CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87071766
166* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86392955
167ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86108767
168RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85780488
169* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83765038
170NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83266944
171PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82876032
172* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82060145
173ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81151620
174GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80991119
175CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80768347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.86653080
2MP0003718_maternal_effect3.59887823
3MP0003693_abnormal_embryo_hatching3.34858580
4MP0010094_abnormal_chromosome_stability2.99155375
5MP0000569_abnormal_digit_pigmentation2.90651591
6MP0008057_abnormal_DNA_replication2.70551962
7MP0004147_increased_porphyrin_level2.56742739
8MP0001835_abnormal_antigen_presentation2.47793232
9MP0003077_abnormal_cell_cycle2.42628547
10MP0008877_abnormal_DNA_methylation2.41940815
11MP0003787_abnormal_imprinting2.35214409
12MP0005408_hypopigmentation2.33092327
13MP0003111_abnormal_nucleus_morphology2.27931056
14MP0004957_abnormal_blastocyst_morpholog2.24600729
15MP0008007_abnormal_cellular_replicative1.98772469
16MP0002877_abnormal_melanocyte_morpholog1.95410294
17MP0005084_abnormal_gallbladder_morpholo1.93181173
18MP0003195_calcinosis1.91610509
19MP0001986_abnormal_taste_sensitivity1.85367017
20MP0002163_abnormal_gland_morphology1.84677455
21MP0005671_abnormal_response_to1.82427898
22MP0005379_endocrine/exocrine_gland_phen1.81670083
23MP0002638_abnormal_pupillary_reflex1.80784415
24MP0009785_altered_susceptibility_to1.79213471
25MP0001119_abnormal_female_reproductive1.72968727
26MP0002396_abnormal_hematopoietic_system1.72948869
27MP0003656_abnormal_erythrocyte_physiolo1.72238257
28MP0005174_abnormal_tail_pigmentation1.71536985
29MP0005395_other_phenotype1.69600557
30MP0008058_abnormal_DNA_repair1.68218282
31MP0003806_abnormal_nucleotide_metabolis1.67126585
32MP0008995_early_reproductive_senescence1.66482565
33MP0003724_increased_susceptibility_to1.65695529
34MP0003186_abnormal_redox_activity1.65611178
35MP0005310_abnormal_salivary_gland1.58312691
36MP0001188_hyperpigmentation1.54364969
37MP0005000_abnormal_immune_tolerance1.52914721
38MP0002419_abnormal_innate_immunity1.52909097
39MP0002148_abnormal_hypersensitivity_rea1.48523546
40MP0003436_decreased_susceptibility_to1.48085910
41MP0000490_abnormal_crypts_of1.47451897
42MP0001800_abnormal_humoral_immune1.45799153
43MP0003699_abnormal_female_reproductive1.45693505
44MP0001929_abnormal_gametogenesis1.43933918
45MP0009333_abnormal_splenocyte_physiolog1.42853959
46MP0002452_abnormal_antigen_presenting1.42220233
47MP0000685_abnormal_immune_system1.41969622
48MP0003890_abnormal_embryonic-extraembry1.41070601
49MP0002723_abnormal_immune_serum1.40788032
50MP0002102_abnormal_ear_morphology1.40730501
51MP0004264_abnormal_extraembryonic_tissu1.39457380
52MP0002876_abnormal_thyroid_physiology1.39118995
53MP0000653_abnormal_sex_gland1.35132338
54MP0000015_abnormal_ear_pigmentation1.34406693
55MP0005025_abnormal_response_to1.33446003
56MP0003763_abnormal_thymus_physiology1.32272310
57MP0006054_spinal_hemorrhage1.31729429
58MP0002277_abnormal_respiratory_mucosa1.31582699
59MP0001790_abnormal_immune_system1.30803099
60MP0005387_immune_system_phenotype1.30803099
61MP0008260_abnormal_autophagy1.28032519
62MP0005551_abnormal_eye_electrophysiolog1.27945306
63MP0001819_abnormal_immune_cell1.27428938
64MP0002210_abnormal_sex_determination1.27095635
65MP0002019_abnormal_tumor_incidence1.26930343
66MP0002420_abnormal_adaptive_immunity1.26247088
67MP0002006_tumorigenesis1.24628553
68MP0002398_abnormal_bone_marrow1.24212845
69MP0004484_altered_response_of1.22363659
70MP0008932_abnormal_embryonic_tissue1.22229196
71MP0003943_abnormal_hepatobiliary_system1.19754073
72MP0000427_abnormal_hair_cycle1.18221490
73MP0004142_abnormal_muscle_tone1.18065945
74MP0005075_abnormal_melanosome_morpholog1.17709529
75MP0000689_abnormal_spleen_morphology1.15493289
76MP0000372_irregular_coat_pigmentation1.15331042
77MP0005365_abnormal_bile_salt1.15028041
78MP0003828_pulmonary_edema1.14560438
79MP0002405_respiratory_system_inflammati1.14199318
80MP0004215_abnormal_myocardial_fiber1.14046203
81MP0000716_abnormal_immune_system1.13276688
82MP0008872_abnormal_physiological_respon1.12643761
83MP0001545_abnormal_hematopoietic_system1.11944764
84MP0005397_hematopoietic_system_phenotyp1.11944764
85MP0002139_abnormal_hepatobiliary_system1.09516964
86MP0009697_abnormal_copulation1.09371074
87MP0000350_abnormal_cell_proliferation1.08974148
88MP0004782_abnormal_surfactant_physiolog1.08921233
89MP0010352_gastrointestinal_tract_polyps1.08871778
90MP0001845_abnormal_inflammatory_respons1.08288665
91MP0002095_abnormal_skin_pigmentation1.07048776
92MP0004808_abnormal_hematopoietic_stem1.06776010
93MP0010307_abnormal_tumor_latency1.06687996
94MP0010155_abnormal_intestine_physiology1.05129209
95MP0005646_abnormal_pituitary_gland1.01894914
96MP0002429_abnormal_blood_cell1.01842204
97MP0001145_abnormal_male_reproductive1.01644421
98MP0001919_abnormal_reproductive_system1.01621225
99MP0004084_abnormal_cardiac_muscle1.01216495
100MP0003698_abnormal_male_reproductive1.00226782
101MP0005253_abnormal_eye_physiology0.98027004
102MP0002722_abnormal_immune_system0.97501590
103MP0005389_reproductive_system_phenotype0.95833536
104MP0005360_urolithiasis0.95719861
105MP0002160_abnormal_reproductive_system0.95307806
106MP0002090_abnormal_vision0.95221999
107MP0003646_muscle_fatigue0.94219748
108MP0005464_abnormal_platelet_physiology0.93390503
109MP0008004_abnormal_stomach_pH0.92166933
110MP0001851_eye_inflammation0.92097110
111MP0002138_abnormal_hepatobiliary_system0.91975193
112MP0006082_CNS_inflammation0.91958183
113MP0000703_abnormal_thymus_morphology0.91908572
114MP0001730_embryonic_growth_arrest0.91678862
115MP0001915_intracranial_hemorrhage0.91162105
116MP0000465_gastrointestinal_hemorrhage0.90710395
117MP0009764_decreased_sensitivity_to0.90252398
118MP0003567_abnormal_fetal_cardiomyocyte0.89585297
119MP0004947_skin_inflammation0.88525805
120MP0004043_abnormal_pH_regulation0.88110433
121MP0001853_heart_inflammation0.87856436
122MP0002928_abnormal_bile_duct0.86731155
123MP0009840_abnormal_foam_cell0.86727786
124MP0001879_abnormal_lymphatic_vessel0.86554744
125MP0000230_abnormal_systemic_arterial0.86218678
126MP0003123_paternal_imprinting0.85644442
127MP0003950_abnormal_plasma_membrane0.85639936
128MP0006036_abnormal_mitochondrial_physio0.85532655
129MP0001346_abnormal_lacrimal_gland0.84439383
130MP0005083_abnormal_biliary_tract0.83889643
131MP0000613_abnormal_salivary_gland0.83538614
132MP0008469_abnormal_protein_level0.82740824
133MP0009763_increased_sensitivity_to0.82703997
134MP0000858_altered_metastatic_potential0.82184921
135MP0002009_preneoplasia0.81768524
136MP0000313_abnormal_cell_death0.81205241
137MP0001529_abnormal_vocalization0.80839568
138MP0001485_abnormal_pinna_reflex0.79709847
139MP0005647_abnormal_sex_gland0.77628164
140MP0006292_abnormal_olfactory_placode0.77342301
141MP0001533_abnormal_skeleton_physiology0.76951684
142MP0003786_premature_aging0.76352625
143MP0005058_abnormal_lysosome_morphology0.76249691
144MP0003448_altered_tumor_morphology0.75793079
145MP0000598_abnormal_liver_morphology0.75769628
146MP0002166_altered_tumor_susceptibility0.75217733
147MP0000579_abnormal_nail_morphology0.75187012
148MP0002693_abnormal_pancreas_physiology0.74881587
149MP0008875_abnormal_xenobiotic_pharmacok0.74521044
150MP0005535_abnormal_body_temperature0.70735363
151MP0009703_decreased_birth_body0.70296724

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.15980537
2Male infertility (HP:0003251)4.07235308
3Volvulus (HP:0002580)3.71452656
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.67867337
5Birth length less than 3rd percentile (HP:0003561)3.61907401
6Recurrent bacterial skin infections (HP:0005406)3.57376615
7Flat capital femoral epiphysis (HP:0003370)3.47272598
8Acute myeloid leukemia (HP:0004808)3.33747646
9Myositis (HP:0100614)3.28739856
10Retrobulbar optic neuritis (HP:0100654)3.26322542
11Optic neuritis (HP:0100653)3.26322542
12Aplastic anemia (HP:0001915)3.23950562
13Recurrent abscess formation (HP:0002722)3.14142946
14Papillary thyroid carcinoma (HP:0002895)3.10111366
15Biliary tract neoplasm (HP:0100574)3.08104300
16Pancreatic cysts (HP:0001737)3.05468385
17Breast hypoplasia (HP:0003187)2.97292936
18Pancreatic fibrosis (HP:0100732)2.95705996
19Orchitis (HP:0100796)2.95365681
20Secondary amenorrhea (HP:0000869)2.90903280
21Dyschromatopsia (HP:0007641)2.87474603
22Abnormality of the renal cortex (HP:0011035)2.87018770
23Stomatitis (HP:0010280)2.85487795
24Hypergonadotropic hypogonadism (HP:0000815)2.82142424
25Autoimmune hemolytic anemia (HP:0001890)2.80324824
26Prolonged bleeding time (HP:0003010)2.77952767
27Abnormality of T cell number (HP:0011839)2.69104655
28Abnormality of chromosome stability (HP:0003220)2.65233102
29Abnormality of midbrain morphology (HP:0002418)2.64424755
30Molar tooth sign on MRI (HP:0002419)2.64424755
31Capillary hemangiomas (HP:0005306)2.59328241
32Adrenal hypoplasia (HP:0000835)2.59155618
33Type 2 muscle fiber atrophy (HP:0003554)2.56587187
34Pulmonary fibrosis (HP:0002206)2.56109753
35Myelodysplasia (HP:0002863)2.51211541
36Eosinophilia (HP:0001880)2.48705687
37Acanthocytosis (HP:0001927)2.46192609
38Poikilocytosis (HP:0004447)2.45688042
39Recurrent skin infections (HP:0001581)2.43303136
40Hyperinsulinemic hypoglycemia (HP:0000825)2.42841370
41Prostate neoplasm (HP:0100787)2.42205186
42Medial flaring of the eyebrow (HP:0010747)2.41684947
43True hermaphroditism (HP:0010459)2.39526774
44Gonadotropin excess (HP:0000837)2.38248737
45Neoplasm of the small intestine (HP:0100833)2.36986673
46Stomach cancer (HP:0012126)2.36588052
47Thyroid carcinoma (HP:0002890)2.35896454
48Abnormal biliary tract morphology (HP:0012440)2.35638890
49Spondylolisthesis (HP:0003302)2.35554658
50Abnormality of the renal medulla (HP:0100957)2.35048520
51Pancreatic islet-cell hyperplasia (HP:0004510)2.33386199
52Abnormality of the prostate (HP:0008775)2.32620066
53Abnormality of the labia minora (HP:0012880)2.32572363
54Abnormal hair whorl (HP:0010721)2.31443845
55Patellar aplasia (HP:0006443)2.30955596
56Insulin-resistant diabetes mellitus (HP:0000831)2.30919503
57Carpal bone hypoplasia (HP:0001498)2.30848664
58Febrile seizures (HP:0002373)2.30638617
59Widely spaced teeth (HP:0000687)2.29101389
60Muscle fiber atrophy (HP:0100295)2.27972508
61Irregular epiphyses (HP:0010582)2.25978537
62Recurrent gram-negative bacterial infections (HP:0005420)2.25124624
63Thyroiditis (HP:0100646)2.23788879
64Neoplasm of the tracheobronchial system (HP:0100552)2.22786970
65Nephronophthisis (HP:0000090)2.22386132
66Abnormality of lateral ventricle (HP:0030047)2.20767802
67Alveolar cell carcinoma (HP:0006519)2.20565560
68Thrombocytosis (HP:0001894)2.20239432
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.18131886
70Fair hair (HP:0002286)2.17934014
71Keratoconjunctivitis sicca (HP:0001097)2.16821903
72Premature ovarian failure (HP:0008209)2.15069335
73Abnormality of the fingertips (HP:0001211)2.14353678
74Autoimmune thrombocytopenia (HP:0001973)2.14343875
75T lymphocytopenia (HP:0005403)2.14269213
76Abnormality of B cell number (HP:0010975)2.13120552
77Eczematoid dermatitis (HP:0000976)2.11907090
78Aplasia/Hypoplasia of the patella (HP:0006498)2.10930011
79Hyperglycemia (HP:0003074)2.10501339
80Abnormality of eosinophils (HP:0001879)2.08357983
81Gastrointestinal infarctions (HP:0005244)2.07120992
823-Methylglutaconic aciduria (HP:0003535)2.06823889
83Facial hemangioma (HP:0000329)2.06382505
84Congenital primary aphakia (HP:0007707)2.06250007
85Abnormality of the preputium (HP:0100587)2.04714568
86Combined immunodeficiency (HP:0005387)2.04690604
87B lymphocytopenia (HP:0010976)2.04504282
88Hypothermia (HP:0002045)2.03816168
89Agnosia (HP:0010524)2.03525865
90Aplasia/Hypoplasia of the uvula (HP:0010293)2.01242133
91Chronic hepatic failure (HP:0100626)2.00859958
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99515172
93Abnormality of alanine metabolism (HP:0010916)1.99515172
94Hyperalaninemia (HP:0003348)1.99515172
95Keratoconjunctivitis (HP:0001096)1.99447296
96Central scotoma (HP:0000603)1.99287587
97Generalized aminoaciduria (HP:0002909)1.99071092
98Exertional dyspnea (HP:0002875)1.98976972
99Increased mean platelet volume (HP:0011877)1.98191376
100Abnormality of T cell physiology (HP:0011840)1.98034260
101Oligodactyly (hands) (HP:0001180)1.95989722
102Abnormality of endocrine pancreas physiology (HP:0012093)1.95385405
103Abnormality of the pancreatic islet cells (HP:0006476)1.95385405
104Bone marrow hypocellularity (HP:0005528)1.95264288
105Renal cortical cysts (HP:0000803)1.94721877
106Pulmonary infiltrates (HP:0002113)1.93077490
107Neoplasm of the colon (HP:0100273)1.92971198
108Abnormal spermatogenesis (HP:0008669)1.92952040
109Abnormality of the femoral head (HP:0003368)1.92329558
110Albinism (HP:0001022)1.91793225
111Ectopic kidney (HP:0000086)1.91546566
112Nephrogenic diabetes insipidus (HP:0009806)1.91382767
113Clubbing of toes (HP:0100760)1.90957190
114Abnormality of the epiphysis of the femoral head (HP:0010574)1.90377131
115Vacuolated lymphocytes (HP:0001922)1.89352516
116Abolished electroretinogram (ERG) (HP:0000550)1.89198765
117Recurrent viral infections (HP:0004429)1.88954199
118Duplicated collecting system (HP:0000081)1.88448789
119Meckel diverticulum (HP:0002245)1.87887170
120Large for gestational age (HP:0001520)1.85598002
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.85574640
122Hypoplastic iliac wings (HP:0002866)1.85083010
123Increased IgM level (HP:0003496)1.84903320
124Severe combined immunodeficiency (HP:0004430)1.83789515
125Abnormality of aromatic amino acid family metabolism (HP:0004338)1.83747388
126Progressive inability to walk (HP:0002505)1.83194123
127Hypoproteinemia (HP:0003075)1.83109847
128Metaphyseal dysplasia (HP:0100255)1.82561564
129Gait imbalance (HP:0002141)1.82340896
130Decreased central vision (HP:0007663)1.82225170
131Median cleft lip (HP:0000161)1.82098769
132Abnormality of methionine metabolism (HP:0010901)1.81909955
133Bile duct proliferation (HP:0001408)1.81504341
134Abnormal biliary tract physiology (HP:0012439)1.81504341
135Abnormality of liposaccharide metabolism (HP:0010968)1.80066472
136Abnormality of glycosphingolipid metabolism (HP:0004343)1.80066472
137Abnormality of glycolipid metabolism (HP:0010969)1.80066472
138Embryonal renal neoplasm (HP:0011794)1.79627480
139Nephroblastoma (Wilms tumor) (HP:0002667)1.79561775
140Abnormality of the pons (HP:0007361)1.79445729
141Gaze-evoked nystagmus (HP:0000640)1.79329241
142Sloping forehead (HP:0000340)1.79085375
143Genital tract atresia (HP:0001827)1.78603788
144Generalized hypopigmentation of hair (HP:0011358)1.78602578
145Pustule (HP:0200039)1.78534807
146Hypoglycemic seizures (HP:0002173)1.77981638
147Granulocytopenia (HP:0001913)1.77264483
148Abnormal platelet volume (HP:0011876)1.76770342
149Abnormal auditory evoked potentials (HP:0006958)1.75868665
150Attenuation of retinal blood vessels (HP:0007843)1.75851427
151Neoplasm of the rectum (HP:0100743)1.75729178
152Recurrent fungal infections (HP:0002841)1.75601697
153Duodenal stenosis (HP:0100867)1.74951454
154Small intestinal stenosis (HP:0012848)1.74951454
155Abnormality of the renal collecting system (HP:0004742)1.74157349
156Poor coordination (HP:0002370)1.73669961
157Deep venous thrombosis (HP:0002625)1.73532122
158Abnormality of the ileum (HP:0001549)1.73191439
159Abnormality of the vasculature of the conjunctiva (HP:0008054)1.72864700
160Aplasia/Hypoplasia of the tibia (HP:0005772)1.71751150
161Hematochezia (HP:0002573)1.71326448
162Cellulitis (HP:0100658)1.71306319
163Abnormality of femoral epiphyses (HP:0006499)1.70904417
164Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.70904417
165Oral leukoplakia (HP:0002745)1.70375103
166Supernumerary spleens (HP:0009799)1.70070122
167Shawl scrotum (HP:0000049)1.69684145
168Leukocytosis (HP:0001974)1.68657016
169Abnormality of the heme biosynthetic pathway (HP:0010472)1.68470234
170Cortical dysplasia (HP:0002539)1.67703238
171Petechiae (HP:0000967)1.67665689
172Spontaneous abortion (HP:0005268)1.67402682
173Encephalitis (HP:0002383)1.67075206
174Congenital hepatic fibrosis (HP:0002612)1.66986701
175Methylmalonic acidemia (HP:0002912)1.66872077
176Abnormality of macrophages (HP:0004311)1.66280974
177Azoospermia (HP:0000027)1.65648897
178Rough bone trabeculation (HP:0100670)1.64947466
179Gangrene (HP:0100758)1.64542858
180Entropion (HP:0000621)1.64340991
181Vasculitis (HP:0002633)1.64004541
182Elevated erythrocyte sedimentation rate (HP:0003565)1.63866738
183Chronic bronchitis (HP:0004469)1.63684376
184Absent radius (HP:0003974)1.63608578
185Chronic otitis media (HP:0000389)1.63223541
186Neutropenia (HP:0001875)1.62938680
187Abnormality of T cells (HP:0002843)1.62394174
188Aplasia/Hypoplasia of the fovea (HP:0008060)1.62020595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.79460331
2PLK43.74029422
3FRK3.39799599
4MUSK3.00915139
5LATS12.75711669
6BRAF2.75311551
7TTK2.63066618
8BCR2.57978092
9MAP3K132.53333405
10ERBB42.52263626
11TNIK2.20789318
12EIF2AK12.18137804
13CDC72.16800117
14MAP3K62.15083471
15PNCK2.05323544
16ACVR1B2.05172534
17MOS2.04248848
18MKNK22.02065037
19EEF2K2.00704945
20STK31.97874220
21STK101.94808780
22BUB11.94582216
23NEK91.93875832
24BMPR21.85732581
25TRIM281.80174177
26NUAK11.78773315
27STK38L1.75898662
28ARAF1.65319622
29MAP3K141.59785956
30TRPM71.50344146
31RAF11.46832712
32EIF2AK31.43798012
33ZAK1.40764797
34CAMKK21.40529228
35MARK31.35007585
36SIK31.34970144
37PAK31.34478131
38NEK21.34053414
39BRD41.33723180
40PBK1.33459705
41STK391.32989767
42NLK1.32932437
43JAK31.32568942
44ERBB31.32129710
45PLK11.32002024
46MELK1.31627692
47MAPKAPK51.29841182
48KSR21.29692531
49BRSK21.28392656
50KIT1.24047995
51IKBKB1.23301322
52MAP4K21.18898889
53BCKDK1.17473136
54MAPKAPK31.16168457
55TEC1.15327145
56WNK31.13835425
57IRAK41.13061956
58PLK21.12813548
59CDK81.12270657
60FER1.08955351
61RPS6KB21.07167673
62MAP4K11.05476732
63EPHA31.05298077
64IRAK11.04327233
65TBK11.03478352
66WEE11.03057915
67OXSR11.02381465
68MAP3K81.02077295
69CHUK1.01289276
70CHEK21.00914680
71VRK11.00248967
72SGK20.98993869
73INSRR0.98316514
74AURKB0.97086764
75IKBKE0.90471567
76TYK20.89139206
77STK40.88982757
78GRK10.86358784
79ABL20.86349706
80STK160.85872422
81PIM10.85515752
82STK240.84399026
83TGFBR20.79344338
84PASK0.78680461
85ADRBK20.77432039
86CDK90.75947823
87MST40.75708277
88TAOK10.75662086
89PIK3CG0.73854046
90PLK30.69435612
91TXK0.69370580
92LATS20.68553040
93MAPK130.67994965
94RPS6KA40.65582248
95FLT30.65265750
96ATR0.64959013
97MAP3K40.64389557
98YES10.64333176
99DYRK30.63853103
100CAMK1G0.63523327
101TAF10.62257592
102EPHB10.62232170
103TESK20.61829670
104PTK2B0.60972869
105TSSK60.59888453
106CSF1R0.56292623
107ITK0.54183500
108CASK0.53661102
109PIM20.52808260
110CHEK10.52537620
111BTK0.51855860
112ATM0.51573046
113FES0.51162831
114JAK20.50638557
115MAPK110.50599772
116PRKAA20.50515402
117PRKCE0.49713174
118SGK30.49444973
119DYRK1A0.48473493
120KSR10.48117762
121PINK10.47968469
122CDK60.46165896
123NEK60.45611310
124CDK70.45072212
125SRPK10.44561233
126AKT30.42327567
127CSNK1G10.41434944
128ERN10.40054177
129BMPR1B0.39125300
130DYRK20.38750281
131ABL10.37706685
132PRKCQ0.37331805
133BRSK10.37041368
134ZAP700.36444599
135IRAK30.34029827
136AURKA0.33968901
137EIF2AK20.33532296
138GRK50.33221410
139CDK40.33009842
140JAK10.31000047
141MKNK10.29511759
142MAP3K50.29057592
143FGFR30.28809349
144HIPK20.28293980
145MAPKAPK20.27038535
146TGFBR10.26916015
147STK110.26855728
148TNK20.26775379
149CDK30.26241889

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.68250885
2Protein export_Homo sapiens_hsa030602.61730127
3Vitamin B6 metabolism_Homo sapiens_hsa007502.61493604
4RNA degradation_Homo sapiens_hsa030182.48022442
5Basal transcription factors_Homo sapiens_hsa030222.44433378
6Nitrogen metabolism_Homo sapiens_hsa009102.44341582
7Homologous recombination_Homo sapiens_hsa034402.40071893
8DNA replication_Homo sapiens_hsa030302.36259874
9Mismatch repair_Homo sapiens_hsa034302.18340317
10Non-homologous end-joining_Homo sapiens_hsa034502.17896760
11RNA polymerase_Homo sapiens_hsa030202.09120748
12Base excision repair_Homo sapiens_hsa034102.06967640
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.87018695
14Fanconi anemia pathway_Homo sapiens_hsa034601.81076673
15Folate biosynthesis_Homo sapiens_hsa007901.80583968
16Nucleotide excision repair_Homo sapiens_hsa034201.71379731
17Propanoate metabolism_Homo sapiens_hsa006401.69564385
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.64903471
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.62002052
20RNA transport_Homo sapiens_hsa030131.61218477
21Linoleic acid metabolism_Homo sapiens_hsa005911.59356194
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58901159
23Phototransduction_Homo sapiens_hsa047441.58574408
24p53 signaling pathway_Homo sapiens_hsa041151.55471050
25Platelet activation_Homo sapiens_hsa046111.53469356
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52229803
27Ovarian steroidogenesis_Homo sapiens_hsa049131.40225488
28Ether lipid metabolism_Homo sapiens_hsa005651.34134339
29Pyrimidine metabolism_Homo sapiens_hsa002401.33129547
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32637646
31Dorso-ventral axis formation_Homo sapiens_hsa043201.32475166
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.30878038
33FoxO signaling pathway_Homo sapiens_hsa040681.29778744
34Herpes simplex infection_Homo sapiens_hsa051681.28960348
35Proteasome_Homo sapiens_hsa030501.24798428
36NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21956231
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.20698252
38One carbon pool by folate_Homo sapiens_hsa006701.15396966
39Allograft rejection_Homo sapiens_hsa053301.12686429
40Histidine metabolism_Homo sapiens_hsa003401.11027774
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10652667
42Other glycan degradation_Homo sapiens_hsa005111.10172473
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.04248807
44Steroid biosynthesis_Homo sapiens_hsa001001.04007920
45mRNA surveillance pathway_Homo sapiens_hsa030151.02899408
46Selenocompound metabolism_Homo sapiens_hsa004501.02175686
47Butanoate metabolism_Homo sapiens_hsa006501.01655919
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99979191
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98114432
50Leishmaniasis_Homo sapiens_hsa051400.98021171
51Legionellosis_Homo sapiens_hsa051340.97457172
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97340101
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97092338
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96096598
55Circadian rhythm_Homo sapiens_hsa047100.95184114
56Pancreatic cancer_Homo sapiens_hsa052120.94473942
57Collecting duct acid secretion_Homo sapiens_hsa049660.92641237
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92332023
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90969397
60Measles_Homo sapiens_hsa051620.90326754
61Caffeine metabolism_Homo sapiens_hsa002320.90109654
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87793486
63Sulfur metabolism_Homo sapiens_hsa009200.87451132
64Prostate cancer_Homo sapiens_hsa052150.85033685
65Graft-versus-host disease_Homo sapiens_hsa053320.84786677
66T cell receptor signaling pathway_Homo sapiens_hsa046600.83140021
67Influenza A_Homo sapiens_hsa051640.79686150
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79444815
69Pentose phosphate pathway_Homo sapiens_hsa000300.79094155
70Serotonergic synapse_Homo sapiens_hsa047260.78933594
71Spliceosome_Homo sapiens_hsa030400.78931815
72Purine metabolism_Homo sapiens_hsa002300.78089724
73Arachidonic acid metabolism_Homo sapiens_hsa005900.77698084
74Epstein-Barr virus infection_Homo sapiens_hsa051690.77294686
75Staphylococcus aureus infection_Homo sapiens_hsa051500.77024486
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75973473
77Type I diabetes mellitus_Homo sapiens_hsa049400.75071599
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73958169
79Antigen processing and presentation_Homo sapiens_hsa046120.73665069
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73236494
81Jak-STAT signaling pathway_Homo sapiens_hsa046300.72953813
82Malaria_Homo sapiens_hsa051440.72312114
83Apoptosis_Homo sapiens_hsa042100.72278860
84Shigellosis_Homo sapiens_hsa051310.72125978
85Glycerolipid metabolism_Homo sapiens_hsa005610.71453858
86Lysine degradation_Homo sapiens_hsa003100.71303305
87Regulation of autophagy_Homo sapiens_hsa041400.71072018
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.70922073
89Glutathione metabolism_Homo sapiens_hsa004800.69934260
90Hepatitis B_Homo sapiens_hsa051610.69325686
91Fatty acid elongation_Homo sapiens_hsa000620.67113866
92Sphingolipid metabolism_Homo sapiens_hsa006000.65928718
93Long-term depression_Homo sapiens_hsa047300.64909628
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.64624832
95TGF-beta signaling pathway_Homo sapiens_hsa043500.63140158
96Colorectal cancer_Homo sapiens_hsa052100.62397989
97TNF signaling pathway_Homo sapiens_hsa046680.62157140
98Hematopoietic cell lineage_Homo sapiens_hsa046400.61952142
99Complement and coagulation cascades_Homo sapiens_hsa046100.61842705
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.61513699
101Pancreatic secretion_Homo sapiens_hsa049720.60418332
102Peroxisome_Homo sapiens_hsa041460.60178090
103Rheumatoid arthritis_Homo sapiens_hsa053230.57899131
104Primary immunodeficiency_Homo sapiens_hsa053400.57457312
105Chemokine signaling pathway_Homo sapiens_hsa040620.56613889
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56032062
107Prolactin signaling pathway_Homo sapiens_hsa049170.56024455
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55654788
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.54284060
110Toxoplasmosis_Homo sapiens_hsa051450.54052487
111Olfactory transduction_Homo sapiens_hsa047400.53360251
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52831609
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52738673
114Autoimmune thyroid disease_Homo sapiens_hsa053200.52697784
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51146612
116Thyroid cancer_Homo sapiens_hsa052160.50180974
117Arginine and proline metabolism_Homo sapiens_hsa003300.50179126
118African trypanosomiasis_Homo sapiens_hsa051430.50140831
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.48935942
120Vitamin digestion and absorption_Homo sapiens_hsa049770.48080285
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47731061
122Small cell lung cancer_Homo sapiens_hsa052220.47674167
123Viral carcinogenesis_Homo sapiens_hsa052030.47369211
124Pertussis_Homo sapiens_hsa051330.47277618
125ABC transporters_Homo sapiens_hsa020100.46250376
126Lysosome_Homo sapiens_hsa041420.45559816
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44095691
128Tryptophan metabolism_Homo sapiens_hsa003800.44078930
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42361454
130Oocyte meiosis_Homo sapiens_hsa041140.41970712
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41021347
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33272695
133Retinol metabolism_Homo sapiens_hsa008300.33252772
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33093687
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31426419
136Renin secretion_Homo sapiens_hsa049240.30156494
137Taste transduction_Homo sapiens_hsa047420.29118419
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28533649
139Amphetamine addiction_Homo sapiens_hsa050310.28163342

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