TBC1D16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)6.26624801
2pyrimidine nucleobase catabolic process (GO:0006208)5.89353246
3layer formation in cerebral cortex (GO:0021819)5.63397517
4melanin metabolic process (GO:0006582)5.58590945
5secondary metabolite biosynthetic process (GO:0044550)4.98251498
6nucleobase catabolic process (GO:0046113)4.66991118
7synaptic vesicle maturation (GO:0016188)4.42108401
8locomotory exploration behavior (GO:0035641)4.38951196
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.37446153
10paraxial mesoderm development (GO:0048339)4.29328363
11planar cell polarity pathway involved in neural tube closure (GO:0090179)4.26107196
12dendrite morphogenesis (GO:0048813)4.25860014
13cell migration in hindbrain (GO:0021535)4.18238107
14regulation of synapse structural plasticity (GO:0051823)4.09046118
15dendritic spine morphogenesis (GO:0060997)4.04915037
16mitochondrion transport along microtubule (GO:0047497)3.93656156
17establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.93656156
18regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.85004507
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.84562601
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.75948066
21establishment of mitochondrion localization (GO:0051654)3.73742284
22central nervous system projection neuron axonogenesis (GO:0021952)3.72595001
23axonal fasciculation (GO:0007413)3.71576704
24vocalization behavior (GO:0071625)3.66588961
25neuron recognition (GO:0008038)3.63061584
26cerebellar Purkinje cell layer development (GO:0021680)3.58442554
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.55440960
28neuron cell-cell adhesion (GO:0007158)3.51966214
29exploration behavior (GO:0035640)3.48814480
30positive regulation of synapse maturation (GO:0090129)3.45198987
31convergent extension (GO:0060026)3.39670836
32regulation of glutamate receptor signaling pathway (GO:1900449)3.38174087
33basement membrane organization (GO:0071711)3.37175568
34axon extension involved in axon guidance (GO:0048846)3.36312199
35neuron projection extension involved in neuron projection guidance (GO:1902284)3.36312199
36activation of protein kinase A activity (GO:0034199)3.29654178
37establishment of nucleus localization (GO:0040023)3.29193085
38protein localization to synapse (GO:0035418)3.28880369
39cell communication by electrical coupling (GO:0010644)3.28831144
40axon extension (GO:0048675)3.14177426
41adherens junction assembly (GO:0034333)3.09314875
42cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07868801
43regulation of synaptic vesicle exocytosis (GO:2000300)3.07745813
44synaptic vesicle exocytosis (GO:0016079)3.03495954
45neuromuscular process controlling balance (GO:0050885)3.01909394
46regulation of dendritic spine morphogenesis (GO:0061001)3.01538960
47clathrin coat assembly (GO:0048268)3.01176364
48Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.01010810
49proline transport (GO:0015824)3.00265748
50positive regulation of axon extension (GO:0045773)3.00229003
51endothelial cell morphogenesis (GO:0001886)2.99632891
52cell communication involved in cardiac conduction (GO:0086065)2.99037800
53organelle transport along microtubule (GO:0072384)2.98083858
54auditory behavior (GO:0031223)2.97969968
55cytoskeletal anchoring at plasma membrane (GO:0007016)2.93916510
56glutamate secretion (GO:0014047)2.93527848
57insulin-like growth factor receptor signaling pathway (GO:0048009)2.91581853
58protein retention in ER lumen (GO:0006621)2.89426249
59gamma-aminobutyric acid transport (GO:0015812)2.89338102
60cerebellum development (GO:0021549)2.89285621
61cerebellar granule cell differentiation (GO:0021707)2.88316279
62central nervous system neuron axonogenesis (GO:0021955)2.86407452
63epithelial cell-cell adhesion (GO:0090136)2.84802250
64neural tube development (GO:0021915)2.84795382
65plasma membrane repair (GO:0001778)2.84093604
66establishment of apical/basal cell polarity (GO:0035089)2.83078431
67postsynaptic membrane organization (GO:0001941)2.82606170
68neurotransmitter-gated ion channel clustering (GO:0072578)2.82603009
69membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.82257843
70negative regulation of microtubule polymerization (GO:0031115)2.82046266
71regulation of establishment of planar polarity (GO:0090175)2.81430755
72neuron projection extension (GO:1990138)2.78269899
73membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.76488565
74synaptic vesicle docking involved in exocytosis (GO:0016081)2.76231992
75neuronal ion channel clustering (GO:0045161)2.76136051
76dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.75641329
77negative regulation of chondrocyte differentiation (GO:0032331)2.75262260
78neurotransmitter secretion (GO:0007269)2.74128195
79negative regulation of potassium ion transmembrane transport (GO:1901380)2.73910367
80positive regulation of dendritic spine morphogenesis (GO:0061003)2.73563460
81regulation of neuronal synaptic plasticity (GO:0048168)2.70967392
82mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.70896767
83regulation of axon extension (GO:0030516)2.70633570
84protein complex localization (GO:0031503)2.70108350
85nerve growth factor signaling pathway (GO:0038180)2.69651282
86regulation of long-term neuronal synaptic plasticity (GO:0048169)2.69406707
87neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.66956324
88positive regulation of dendritic spine development (GO:0060999)2.65341163
89cardiac myofibril assembly (GO:0055003)2.64066715
90negative regulation of catenin import into nucleus (GO:0035414)2.63903646
91enteric nervous system development (GO:0048484)2.63790015
92maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.63677474
93regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63011405
94non-canonical Wnt signaling pathway (GO:0035567)2.62521081
95protein heterotrimerization (GO:0070208)2.62304144
96glial cell proliferation (GO:0014009)2.61903763
97camera-type eye morphogenesis (GO:0048593)2.61364150
98regulation of membrane repolarization (GO:0060306)2.60767488
99regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.60501001
100regulation of mammary gland epithelial cell proliferation (GO:0033599)2.60182726
101regulation of synaptic vesicle transport (GO:1902803)2.58328955
102synapse organization (GO:0050808)2.57152155
103regulation of neuron migration (GO:2001222)2.57092108
104regulation of ARF protein signal transduction (GO:0032012)2.56792233
105notochord development (GO:0030903)2.56145580
106branching involved in salivary gland morphogenesis (GO:0060445)2.55712300
107dopamine receptor signaling pathway (GO:0007212)2.54925425
108vesicle transport along microtubule (GO:0047496)2.54299361
109axon cargo transport (GO:0008088)2.52504247
110establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.52428133
111membrane repolarization during action potential (GO:0086011)2.51401282
112cerebral cortex radially oriented cell migration (GO:0021799)2.51231150
113dendritic spine organization (GO:0097061)2.50798753
114embryonic retina morphogenesis in camera-type eye (GO:0060059)2.50655440
115establishment or maintenance of monopolar cell polarity (GO:0061339)2.50040480
116establishment of monopolar cell polarity (GO:0061162)2.50040480
117apical protein localization (GO:0045176)2.49976944
118retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49931810
119vascular endothelial growth factor signaling pathway (GO:0038084)2.49664955
120ionotropic glutamate receptor signaling pathway (GO:0035235)2.49066584
121regulation of NFAT protein import into nucleus (GO:0051532)2.48944958
122prepulse inhibition (GO:0060134)2.48720014
123cell-substrate adherens junction assembly (GO:0007045)2.48587988
124focal adhesion assembly (GO:0048041)2.48587988
125negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.48275939
126regulation of dendritic spine development (GO:0060998)2.48253767
127myelination in peripheral nervous system (GO:0022011)2.48107407
128peripheral nervous system axon ensheathment (GO:0032292)2.48107407
129neuron projection morphogenesis (GO:0048812)2.47881881
130synapse assembly (GO:0007416)2.47387798
131negative regulation of fatty acid transport (GO:2000192)2.47284664
132regulation of catenin import into nucleus (GO:0035412)2.47268650
133endothelial cell chemotaxis (GO:0035767)2.45849944
134regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.45581779
135regulation of synapse maturation (GO:0090128)2.43124869
136semaphorin-plexin signaling pathway (GO:0071526)2.43102785
137cochlea morphogenesis (GO:0090103)2.43043880
138chondrocyte proliferation (GO:0035988)2.42798035
139positive regulation of dendrite development (GO:1900006)2.42635355
140response to auditory stimulus (GO:0010996)2.42139276
141cellular protein complex localization (GO:0034629)2.41970707
142regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.41966978
143transmission of nerve impulse (GO:0019226)2.41617577
144regulation of extent of cell growth (GO:0061387)2.41377425
145lung-associated mesenchyme development (GO:0060484)2.40230779
146regulation of axon extension involved in axon guidance (GO:0048841)2.39928744
147cell junction maintenance (GO:0034331)2.39343627
148negative regulation of cytosolic calcium ion concentration (GO:0051481)2.38688084
149hippo signaling (GO:0035329)2.38610992
150cell-substrate junction assembly (GO:0007044)2.38497374
151positive regulation of filopodium assembly (GO:0051491)2.38478820
152establishment or maintenance of bipolar cell polarity (GO:0061245)2.38167596
153establishment or maintenance of apical/basal cell polarity (GO:0035088)2.38167596
154cerebral cortex neuron differentiation (GO:0021895)2.38039491
155positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.37411873
156hippocampus development (GO:0021766)2.37370743
157positive regulation of potassium ion transmembrane transport (GO:1901381)2.37003940
158melanocyte differentiation (GO:0030318)2.36256393
159regulation of glucose import in response to insulin stimulus (GO:2001273)2.33032313
160G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.32687661
161heterochromatin organization (GO:0070828)2.31956477
162cell-cell junction maintenance (GO:0045217)2.31546551
163negative regulation of cell size (GO:0045792)2.30758536
164positive regulation of neuroblast proliferation (GO:0002052)2.29790054
165ganglion development (GO:0061548)2.27296002
166cell migration involved in sprouting angiogenesis (GO:0002042)2.27235394
167regulation of gene silencing by RNA (GO:0060966)2.26051837
168regulation of posttranscriptional gene silencing (GO:0060147)2.26051837
169regulation of gene silencing by miRNA (GO:0060964)2.26051837
170cell migration involved in heart development (GO:0060973)2.25786497
171eye morphogenesis (GO:0048592)2.24928856
172L-serine metabolic process (GO:0006563)2.24908593
173ectodermal placode formation (GO:0060788)2.20487173
174pigment cell differentiation (GO:0050931)2.20174182
175regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.19397139
176COPI coating of Golgi vesicle (GO:0048205)2.19170346
177Golgi transport vesicle coating (GO:0048200)2.19170346
178positive regulation of smoothened signaling pathway (GO:0045880)2.18470190
179negative regulation of cell fate specification (GO:0009996)2.18286655
180biotin metabolic process (GO:0006768)2.16072832
181pre-miRNA processing (GO:0031054)2.15614299
182regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.15558492
183negative regulation of cartilage development (GO:0061037)2.15146906
184somatic stem cell division (GO:0048103)2.15014788
185gap junction assembly (GO:0016264)2.13854741
186nucleosome disassembly (GO:0006337)2.13419867
187protein-DNA complex disassembly (GO:0032986)2.13419867
188hemidesmosome assembly (GO:0031581)2.13362967
189tyrosine metabolic process (GO:0006570)2.12771267
190barbed-end actin filament capping (GO:0051016)2.11239797
191retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.11033170
192lens morphogenesis in camera-type eye (GO:0002089)2.09859585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.34607336
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.84305463
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53941460
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49935803
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.48851900
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47909780
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.46028093
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44394628
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44394628
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43989464
11DROSHA_22980978_ChIP-Seq_HELA_Human2.41534555
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.28032896
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27207776
14* EZH2_27294783_Chip-Seq_ESCs_Mouse2.25964836
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.22877093
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22365066
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22229005
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18097812
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17351282
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16146004
21REST_21632747_ChIP-Seq_MESCs_Mouse2.13921736
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07790673
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.06732667
24CLOCK_20551151_ChIP-Seq_293T_Human2.04715675
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04051009
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98123976
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.97776704
28ZFP281_18757296_ChIP-ChIP_E14_Mouse1.94439176
29GBX2_23144817_ChIP-Seq_PC3_Human1.92984860
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90741274
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90634183
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.88958191
33RACK7_27058665_Chip-Seq_MCF-7_Human1.87356478
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.85301266
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.84506621
36* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.82980064
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82372806
38* KDM2B_26808549_Chip-Seq_K562_Human1.80484520
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80092398
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79436409
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72199653
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72082726
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.71072102
44* ELK3_25401928_ChIP-Seq_HUVEC_Human1.70308918
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.69162216
46EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67654160
47* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65012010
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62296609
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61821311
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.61256312
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.60806039
52* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53336785
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51412426
54RING1B_27294783_Chip-Seq_ESCs_Mouse1.49673435
55* RING1B_27294783_Chip-Seq_NPCs_Mouse1.49375010
56* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.46314370
57AR_21572438_ChIP-Seq_LNCaP_Human1.46030406
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45668150
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45400456
60* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41469885
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40891768
62DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39577791
63ZNF274_21170338_ChIP-Seq_K562_Hela1.39348571
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37718503
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.37126511
66E2F7_22180533_ChIP-Seq_HELA_Human1.36278190
67ZNF263_19887448_ChIP-Seq_K562_Human1.32177316
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.31814534
69* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31676683
70* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28471287
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27798602
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.26885234
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26771091
74* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25174356
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25006255
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25006255
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25006255
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21704280
79* AR_19668381_ChIP-Seq_PC3_Human1.21651714
80PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21279065
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21212531
82KDM2B_26808549_Chip-Seq_DND41_Human1.20468279
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19107241
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18524350
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18416861
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18144430
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17562336
88RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16921439
89ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16670493
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16313728
91POU5F1_16518401_ChIP-PET_MESCs_Mouse1.15391745
92CTCF_27219007_Chip-Seq_Bcells_Human1.15309643
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14924093
94TP53_22127205_ChIP-Seq_IMR90_Human1.14647173
95ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.14452903
96* KDM2B_26808549_Chip-Seq_JURKAT_Human1.14178929
97ISL1_27105846_Chip-Seq_CPCs_Mouse1.11784686
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11350065
99* SMC4_20622854_ChIP-Seq_HELA_Human1.11249604
100AR_21909140_ChIP-Seq_LNCAP_Human1.11021596
101* LXR_22292898_ChIP-Seq_THP-1_Human1.10471456
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09707881
103HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09498982
104SMAD4_21741376_ChIP-Seq_HESCs_Human1.09278114
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.08658911
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.08024015
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07828820
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07564175
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.07449184
110TET1_21451524_ChIP-Seq_MESCs_Mouse1.06722372
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06707634
112AHR_22903824_ChIP-Seq_MCF-7_Human1.05656917
113* TP53_23651856_ChIP-Seq_MEFs_Mouse1.05180186
114NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05072328
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04967917
116TCF7_22412390_ChIP-Seq_EML_Mouse1.03408029
117SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02638657
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.01932723
119* RUNX1_27514584_Chip-Seq_MCF-7_Human1.01597955
120TP53_20018659_ChIP-ChIP_R1E_Mouse1.01321326
121* MITF_21258399_ChIP-Seq_MELANOMA_Human1.00401748
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00313091
123SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99829936
124UBF1/2_26484160_Chip-Seq_HMECs_Human0.99628627
125CBX2_27304074_Chip-Seq_ESCs_Mouse0.99274279
126P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97253510
127* CREB1_26743006_Chip-Seq_LNCaP_Human0.97165727
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.95684491
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92860463
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92795722
131SMAD4_21799915_ChIP-Seq_A2780_Human0.92279896
132ESR2_21235772_ChIP-Seq_MCF-7_Human0.92196137
133IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91141932
134ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90941754
135CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90852913
136SMAD3_21741376_ChIP-Seq_EPCs_Human0.89432570
137ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88016709
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87800811
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.87092071
140STAT3_23295773_ChIP-Seq_U87_Human0.86165448
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85382797
142CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85242361
143NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84228211
144VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.83845533
145RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83527464
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83423780
147WT1_19549856_ChIP-ChIP_CCG9911_Human0.83017580
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81641111
149KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80622108

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.87508046
2MP0003136_yellow_coat_color4.81050075
3MP0004859_abnormal_synaptic_plasticity4.60728581
4MP0005257_abnormal_intraocular_pressure3.79461138
5MP0004270_analgesia3.63987996
6MP0005409_darkened_coat_color3.30793102
7MP0009780_abnormal_chondrocyte_physiolo3.17672225
8MP0008438_abnormal_cutaneous_collagen3.06794827
9MP0003635_abnormal_synaptic_transmissio2.87370693
10MP0000372_irregular_coat_pigmentation2.71044818
11MP0000778_abnormal_nervous_system2.61088193
12MP0005423_abnormal_somatic_nervous2.55194946
13MP0002837_dystrophic_cardiac_calcinosis2.46433666
14MP0004272_abnormal_basement_membrane2.44569984
15MP0002909_abnormal_adrenal_gland2.36153131
16MP0002063_abnormal_learning/memory/cond2.35671321
17MP0010030_abnormal_orbit_morphology2.35501542
18MP0003283_abnormal_digestive_organ2.25789270
19MP0005408_hypopigmentation2.21333488
20MP0004858_abnormal_nervous_system2.14933546
21MP0002877_abnormal_melanocyte_morpholog2.09810300
22MP0002734_abnormal_mechanical_nocicepti2.08665805
23MP0000566_synostosis2.08110956
24MP0005187_abnormal_penis_morphology2.01086179
25MP0000751_myopathy2.00966620
26MP0004885_abnormal_endolymph1.95371310
27MP0003880_abnormal_central_pattern1.95197775
28MP0001849_ear_inflammation1.94493230
29MP0003329_amyloid_beta_deposits1.89033469
30MP0009745_abnormal_behavioral_response1.88785078
31MP0000015_abnormal_ear_pigmentation1.84614861
32MP0000955_abnormal_spinal_cord1.82580871
33MP0002089_abnormal_postnatal_growth/wei1.79449495
34MP0002184_abnormal_innervation1.73843030
35MP0000537_abnormal_urethra_morphology1.69994733
36MP0002064_seizures1.69549268
37MP0002733_abnormal_thermal_nociception1.69000769
38MP0004811_abnormal_neuron_physiology1.68533838
39MP0003941_abnormal_skin_development1.68262413
40MP0003137_abnormal_impulse_conducting1.65168532
41MP0002572_abnormal_emotion/affect_behav1.65151192
42MP0001486_abnormal_startle_reflex1.56553783
43MP0000569_abnormal_digit_pigmentation1.55006276
44MP0000371_diluted_coat_color1.54836165
45MP0004381_abnormal_hair_follicle1.54479349
46MP0004130_abnormal_muscle_cell1.51431920
47MP0004145_abnormal_muscle_electrophysio1.47119682
48MP0004924_abnormal_behavior1.46029675
49MP0005386_behavior/neurological_phenoty1.46029675
50MP0002234_abnormal_pharynx_morphology1.44806490
51MP0002822_catalepsy1.43805251
52MP0004233_abnormal_muscle_weight1.43200668
53MP0001440_abnormal_grooming_behavior1.42647026
54MP0002557_abnormal_social/conspecific_i1.41140436
55MP0001348_abnormal_lacrimal_gland1.40754010
56MP0009046_muscle_twitch1.39823425
57MP0004084_abnormal_cardiac_muscle1.39196346
58MP0002075_abnormal_coat/hair_pigmentati1.39191720
59MP0004085_abnormal_heartbeat1.38130132
60MP0003942_abnormal_urinary_system1.37490161
61MP0004215_abnormal_myocardial_fiber1.36691478
62MP0002249_abnormal_larynx_morphology1.35618546
63MP0009053_abnormal_anal_canal1.34964732
64MP0008961_abnormal_basal_metabolism1.34281258
65MP0002882_abnormal_neuron_morphology1.34245347
66MP0005670_abnormal_white_adipose1.34030031
67MP0002697_abnormal_eye_size1.33667835
68MP0003566_abnormal_cell_adhesion1.31747415
69MP0001970_abnormal_pain_threshold1.28858179
70MP0002152_abnormal_brain_morphology1.28162356
71MP0001968_abnormal_touch/_nociception1.28123883
72MP0002938_white_spotting1.27333185
73MP0002735_abnormal_chemical_nociception1.27186877
74MP0003119_abnormal_digestive_system1.23642596
75MP0001299_abnormal_eye_distance/1.23547803
76MP0003122_maternal_imprinting1.22333735
77MP0002067_abnormal_sensory_capabilities1.22246188
78MP0005503_abnormal_tendon_morphology1.21384682
79MP0003705_abnormal_hypodermis_morpholog1.20129234
80MP0005197_abnormal_uvea_morphology1.20118285
81MP0002066_abnormal_motor_capabilities/c1.18843140
82MP0002272_abnormal_nervous_system1.18745016
83MP0008569_lethality_at_weaning1.18665622
84MP0005275_abnormal_skin_tensile1.14109975
85MP0010368_abnormal_lymphatic_system1.13041608
86MP0004087_abnormal_muscle_fiber1.12688317
87MP0001186_pigmentation_phenotype1.11782629
88MP0003878_abnormal_ear_physiology1.11690486
89MP0005377_hearing/vestibular/ear_phenot1.11690486
90MP0003634_abnormal_glial_cell1.11271663
91MP0003861_abnormal_nervous_system1.10188362
92MP0005248_abnormal_Harderian_gland1.08912125
93MP0000428_abnormal_craniofacial_morphol1.07116898
94MP0004036_abnormal_muscle_relaxation1.06444464
95MP0005508_abnormal_skeleton_morphology1.06439317
96MP0009384_cardiac_valve_regurgitation1.05973523
97MP0003115_abnormal_respiratory_system1.05902613
98MP0000747_muscle_weakness1.05758478
99MP0000733_abnormal_muscle_development1.05129097
100MP0005623_abnormal_meninges_morphology1.00633497
101MP0000579_abnormal_nail_morphology1.00511340
102MP0000049_abnormal_middle_ear0.99715374
103MP0000631_abnormal_neuroendocrine_gland0.99711196
104MP0004043_abnormal_pH_regulation0.99588749
105MP0002116_abnormal_craniofacial_bone0.98441285
106MP0003937_abnormal_limbs/digits/tail_de0.98254175
107MP0005620_abnormal_muscle_contractility0.97936001
108MP0000013_abnormal_adipose_tissue0.97810166
109MP0003279_aneurysm0.97564174
110MP0000432_abnormal_head_morphology0.96980870
111MP0001324_abnormal_eye_pigmentation0.96702652
112MP0002972_abnormal_cardiac_muscle0.96484516
113MP0000534_abnormal_ureter_morphology0.95238425
114MP0003123_paternal_imprinting0.93592536
115MP0000762_abnormal_tongue_morphology0.93565633
116MP0002092_abnormal_eye_morphology0.93142436
117MP0002896_abnormal_bone_mineralization0.93043070
118MP0005666_abnormal_adipose_tissue0.92768584
119MP0004185_abnormal_adipocyte_glucose0.92658962
120MP0003633_abnormal_nervous_system0.92259232
121MP0009250_abnormal_appendicular_skeleto0.91731066
122MP0005330_cardiomyopathy0.91321459
123MP0003787_abnormal_imprinting0.90928001
124MP0003221_abnormal_cardiomyocyte_apopto0.90192094
125MP0003755_abnormal_palate_morphology0.87752816
126MP0002095_abnormal_skin_pigmentation0.87747330
127MP0005174_abnormal_tail_pigmentation0.87664848
128MP0006138_congestive_heart_failure0.86239088
129MP0002254_reproductive_system_inflammat0.85572333
130MP0002069_abnormal_eating/drinking_beha0.84704153
131MP0006276_abnormal_autonomic_nervous0.82494030
132MP0003935_abnormal_craniofacial_develop0.82154704
133MP0005075_abnormal_melanosome_morpholog0.81803647
134MP0003385_abnormal_body_wall0.81165326
135MP0002108_abnormal_muscle_morphology0.81105046
136MP0000462_abnormal_digestive_system0.80783918
137MP0001958_emphysema0.80296783
138MP0003879_abnormal_hair_cell0.79948561
139MP0002085_abnormal_embryonic_tissue0.79853847
140MP0000767_abnormal_smooth_muscle0.79054749
141MP0000467_abnormal_esophagus_morphology0.78273549
142MP0000003_abnormal_adipose_tissue0.77833390
143MP0009672_abnormal_birth_weight0.77515947
144MP0003631_nervous_system_phenotype0.77277449
145MP0001915_intracranial_hemorrhage0.77195856
146MP0010630_abnormal_cardiac_muscle0.75680548
147MP0000920_abnormal_myelination0.75644889
148MP0000604_amyloidosis0.75152875
149MP0002060_abnormal_skin_morphology0.75135855
150MP0002084_abnormal_developmental_patter0.74921244
151MP0002269_muscular_atrophy0.74020631
152MP0003890_abnormal_embryonic-extraembry0.73959786
153MP0003690_abnormal_glial_cell0.73858014
154MP0003632_abnormal_nervous_system0.73848999
155MP0003091_abnormal_cell_migration0.73580449
156MP0010234_abnormal_vibrissa_follicle0.71780988
157MP0003646_muscle_fatigue0.71077594
158MP0002106_abnormal_muscle_physiology0.71046698
159MP0002736_abnormal_nociception_after0.71001748
160MP0008932_abnormal_embryonic_tissue0.70665515
161MP0005058_abnormal_lysosome_morphology0.70125670
162MP0002233_abnormal_nose_morphology0.69992240
163MP0002229_neurodegeneration0.69909487
164MP0005375_adipose_tissue_phenotype0.69533030
165MP0002177_abnormal_outer_ear0.68869080
166MP0002081_perinatal_lethality0.68459525
167MP0001984_abnormal_olfaction0.68234864
168MP0005076_abnormal_cell_differentiation0.68115769
169MP0000759_abnormal_skeletal_muscle0.68084909
170MP0002111_abnormal_tail_morphology0.67540558
171MP0003172_abnormal_lysosome_physiology0.67498885
172MP0002751_abnormal_autonomic_nervous0.67122562
173MP0002078_abnormal_glucose_homeostasis0.66868311
174MP0002932_abnormal_joint_morphology0.65492711
175MP0009703_decreased_birth_body0.65179421

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)3.97996685
2Premature rupture of membranes (HP:0001788)3.61420348
3Myokymia (HP:0002411)3.59825714
4Supranuclear gaze palsy (HP:0000605)3.50779168
5Cerebral inclusion bodies (HP:0100314)3.34854161
6Hypopigmentation of the fundus (HP:0007894)3.22414881
7Neurofibrillary tangles (HP:0002185)3.22066152
8Abnormality of the corticospinal tract (HP:0002492)3.18943546
9Amyotrophic lateral sclerosis (HP:0007354)3.13376183
10Mutism (HP:0002300)3.06166362
11Hepatoblastoma (HP:0002884)3.03517309
12Visual hallucinations (HP:0002367)2.99753291
13Cerebral aneurysm (HP:0004944)2.98061933
14Blue irides (HP:0000635)2.96102998
15Ankle clonus (HP:0011448)2.93670928
16Insidious onset (HP:0003587)2.93281657
17Termporal pattern (HP:0011008)2.93281657
18Ulnar bowing (HP:0003031)2.93045371
19White forelock (HP:0002211)2.89436646
20Insomnia (HP:0100785)2.84621762
21Sudden death (HP:0001699)2.70424475
22Hyperacusis (HP:0010780)2.69959754
23Papilledema (HP:0001085)2.61001563
24Ocular albinism (HP:0001107)2.60334701
25Broad metatarsal (HP:0001783)2.58331209
26Megalencephaly (HP:0001355)2.55368839
27Elfin facies (HP:0004428)2.54412146
28Abnormality of the lower motor neuron (HP:0002366)2.53749437
29Excessive salivation (HP:0003781)2.48240298
30Drooling (HP:0002307)2.48240298
31Focal seizures (HP:0007359)2.45273734
32Ankle contracture (HP:0006466)2.41336066
33Obstructive sleep apnea (HP:0002870)2.41315255
34Asymmetry of the thorax (HP:0001555)2.39446621
35Macroorchidism (HP:0000053)2.39376646
36Aplasia/Hypoplasia of the macula (HP:0008059)2.36812031
37Akinesia (HP:0002304)2.36704906
38Patchy hypopigmentation of hair (HP:0011365)2.36235657
39Agitation (HP:0000713)2.35099657
40Shallow orbits (HP:0000586)2.34427321
41Urinary urgency (HP:0000012)2.34376059
42Aplasia of the phalanges of the hand (HP:0009802)2.33375175
43Aplasia involving bones of the extremities (HP:0009825)2.33375175
44Aplasia involving bones of the upper limbs (HP:0009823)2.33375175
45Lymphangioma (HP:0100764)2.33132582
46Action tremor (HP:0002345)2.31849247
47Poor eye contact (HP:0000817)2.31720155
48Overriding aorta (HP:0002623)2.30481018
49Iris hypopigmentation (HP:0007730)2.28639240
50Coronal craniosynostosis (HP:0004440)2.28407673
51Apathy (HP:0000741)2.26581952
52Bundle branch block (HP:0011710)2.26485627
53Prolonged QT interval (HP:0001657)2.26102568
54Spinal rigidity (HP:0003306)2.26001430
55Depression (HP:0000716)2.25912935
56Morphological abnormality of the pyramidal tract (HP:0002062)2.25482945
57Spastic gait (HP:0002064)2.24913790
58Renal duplication (HP:0000075)2.24312138
59Pachygyria (HP:0001302)2.24237517
60Bladder diverticulum (HP:0000015)2.23482184
61Abnormal social behavior (HP:0012433)2.23337735
62Impaired social interactions (HP:0000735)2.23337735
63Urinary bladder sphincter dysfunction (HP:0002839)2.22432434
64Ketoacidosis (HP:0001993)2.22055106
65Disproportionate tall stature (HP:0001519)2.20931537
66Limb dystonia (HP:0002451)2.20926911
67Genetic anticipation (HP:0003743)2.20648361
68Hypoplasia of the fovea (HP:0007750)2.20342536
69Aplasia/Hypoplasia of the fovea (HP:0008060)2.20342536
70Vertebral compression fractures (HP:0002953)2.20271174
71Aplasia/Hypoplasia affecting the retina (HP:0008061)2.18867797
72Hypsarrhythmia (HP:0002521)2.18172657
73Torticollis (HP:0000473)2.17975168
74Bronchomalacia (HP:0002780)2.17141512
75Inappropriate behavior (HP:0000719)2.17120355
76Subacute progressive viral hepatitis (HP:0006572)2.16469496
77EEG with generalized epileptiform discharges (HP:0011198)2.13220503
78Broad-based gait (HP:0002136)2.13139799
79Pheochromocytoma (HP:0002666)2.12674704
80Renovascular hypertension (HP:0100817)2.10968482
81Arnold-Chiari malformation (HP:0002308)2.10664363
82Arterial tortuosity (HP:0005116)2.09978662
83Impaired vibration sensation in the lower limbs (HP:0002166)2.09515814
84Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.09322136
85Neonatal short-limb short stature (HP:0008921)2.07834703
86Cortical dysplasia (HP:0002539)2.06720896
87Heterochromia iridis (HP:0001100)2.06547736
88Vascular tortuosity (HP:0004948)2.05133874
89Ventricular fibrillation (HP:0001663)2.04994386
90Difficulty running (HP:0009046)2.04598624
91Exercise-induced myalgia (HP:0003738)2.04318499
92Neoplasm of the heart (HP:0100544)2.03422420
93Broad face (HP:0000283)2.02499021
94Hypoplasia of the iris (HP:0007676)2.01704458
95Epileptiform EEG discharges (HP:0011182)2.01431150
96Hamartoma of the eye (HP:0010568)2.00822916
97Hypoventilation (HP:0002791)2.00171836
98Genu recurvatum (HP:0002816)2.00023692
99Turricephaly (HP:0000262)1.99769306
100Hemiparesis (HP:0001269)1.99343357
101Diminished motivation (HP:0000745)1.99226355
102Lower limb muscle weakness (HP:0007340)1.99030874
103Pointed chin (HP:0000307)1.97282002
104Biconcave vertebral bodies (HP:0004586)1.96859397
105Epileptic encephalopathy (HP:0200134)1.93802931
106Choanal stenosis (HP:0000452)1.93624180
107Vertebral arch anomaly (HP:0008438)1.93240994
108Intention tremor (HP:0002080)1.93110484
109Abnormality of dentin (HP:0010299)1.92962698
110Blue sclerae (HP:0000592)1.91809537
111Cervical subluxation (HP:0003308)1.91261430
112Natal tooth (HP:0000695)1.90985101
113Wormian bones (HP:0002645)1.90214713
114Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.89906590
115Short 4th metacarpal (HP:0010044)1.89906590
116Progressive cerebellar ataxia (HP:0002073)1.89557899
117Sacral dimple (HP:0000960)1.88944081
118Abnormality of the distal phalanx of the thumb (HP:0009617)1.88741352
119Bowel diverticulosis (HP:0005222)1.86522947
120Hyporeflexia of lower limbs (HP:0002600)1.86279466
121Mitral valve prolapse (HP:0001634)1.86158831
122Abnormality of the astrocytes (HP:0100707)1.85733733
123Astrocytoma (HP:0009592)1.85733733
124Anxiety (HP:0000739)1.84522567
125Hypoplasia of the brainstem (HP:0002365)1.84469598
126Aplasia/Hypoplasia of the brainstem (HP:0007362)1.84469598
127Broad thumb (HP:0011304)1.84255194
128High anterior hairline (HP:0009890)1.84044322
129Buphthalmos (HP:0000557)1.83182467
130Lower limb amyotrophy (HP:0007210)1.82902906
131Abnormality of the 4th metacarpal (HP:0010012)1.82068363
132Advanced eruption of teeth (HP:0006288)1.81885103
133Syncope (HP:0001279)1.81656328
134Disinhibition (HP:0000734)1.81636250
135Ankyloglossia (HP:0010296)1.81000091
136Wide anterior fontanel (HP:0000260)1.79516788
137Degeneration of the lateral corticospinal tracts (HP:0002314)1.79505368
138Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79505368
139Precocious puberty (HP:0000826)1.77767349
140Soft skin (HP:0000977)1.76980847
141Flat cornea (HP:0007720)1.76839046
142Primary atrial arrhythmia (HP:0001692)1.75870255
143Postural instability (HP:0002172)1.75724667
144Focal dystonia (HP:0004373)1.75055702
145Focal motor seizures (HP:0011153)1.75028349
146Atrial fibrillation (HP:0005110)1.73407010
147Dysdiadochokinesis (HP:0002075)1.73091357
148Distal upper limb amyotrophy (HP:0007149)1.73015277
149Upper limb amyotrophy (HP:0009129)1.73015277
150Craniofacial dystonia (HP:0012179)1.72907379
151Rapidly progressive (HP:0003678)1.72185518
152Abnormal EKG (HP:0003115)1.72046942
153Neuronal loss in central nervous system (HP:0002529)1.71247370
154Thin ribs (HP:0000883)1.70924152
155Partial duplication of the phalanx of hand (HP:0009999)1.69983932
156Increased variability in muscle fiber diameter (HP:0003557)1.69775166
157Pterygium (HP:0001059)1.69599053
158Hyperextensible skin (HP:0000974)1.68954280
159Germ cell neoplasia (HP:0100728)1.68912833
160Mitral regurgitation (HP:0001653)1.68821627
161Fragile skin (HP:0001030)1.68140639
162Aortic dissection (HP:0002647)1.67870513
163Shawl scrotum (HP:0000049)1.67575728
164Short nail (HP:0001799)1.67315248
165Selective tooth agenesis (HP:0001592)1.66920043
166Trigonocephaly (HP:0000243)1.65845733
167Joint laxity (HP:0001388)1.64525612
168Partial duplication of thumb phalanx (HP:0009944)1.63381104
169Morphological abnormality of the middle ear (HP:0008609)1.61029559
170Broad finger (HP:0001500)1.60204904
171Abnormality of the fovea (HP:0000493)1.60178172
172Long palpebral fissure (HP:0000637)1.59899270
173Broad phalanges of the hand (HP:0009768)1.59282181
174Broad long bones (HP:0005622)1.56175305
175Increased connective tissue (HP:0009025)1.55981355
176Abnormality of the phalanges of the hallux (HP:0010057)1.55882175
177Achilles tendon contracture (HP:0001771)1.55817720
178Atrophic scars (HP:0001075)1.55438554
179Midface retrusion (HP:0011800)1.55039849
180Flat acetabular roof (HP:0003180)1.54484959
181Bowed forearm bones (HP:0003956)1.53762609
182Bowing of the arm (HP:0006488)1.53762609
183Cutaneous syndactyly (HP:0012725)1.53481261
184Overgrowth (HP:0001548)1.51725124
185Broad phalanx (HP:0006009)1.51574371
186Long toe (HP:0010511)1.51272643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.66686160
2MAP3K93.03248319
3PHKG12.82410792
4PHKG22.82410792
5SMG12.48889427
6SIK12.45192715
7TRIB32.39824383
8PAK62.12195206
9CDK122.04023838
10PKN22.03283209
11NTRK32.00502305
12FGFR41.93249938
13EPHA41.87403720
14MAP3K41.85823697
15MINK11.84046908
16NTRK21.81663277
17DYRK21.80833271
18LATS21.74482915
19CAMK1D1.69422110
20DAPK21.67674974
21PRKD31.65670550
22NTRK11.63222344
23ICK1.59186412
24CAMKK11.54387707
25KSR21.51104032
26KSR11.49968185
27SIK21.49150052
28PAK41.46023267
29RIPK11.34921965
30UHMK11.33830042
31MAPK131.33190279
32TYRO31.29813644
33PDGFRA1.28680893
34CSNK1G21.28000423
35SCYL21.26725215
36EPHB21.25954597
37ERBB31.24508690
38MARK21.23275807
39PAK31.21087655
40CDK51.19923308
41RET1.19704617
42TAOK11.19078426
43MAP3K21.16543141
44EPHA21.11987813
45PKN11.11220127
46LMTK21.04136506
47ALK1.01442757
48PTK61.00885923
49STK110.97346678
50CSNK1A1L0.97178164
51CAMK1G0.96344284
52MAP2K40.93736525
53CSNK1G30.92600011
54FGFR20.91786223
55TTN0.89904406
56CDK60.89847403
57PRKD20.89169685
58CDK70.88456453
59DMPK0.83972246
60PRKCH0.83018614
61INSRR0.81618055
62MAP3K100.81308564
63RPS6KA20.79422359
64MST1R0.79132033
65DYRK1B0.79078949
66PRKCZ0.74972416
67CDK150.73039371
68CDK140.72577520
69CDC42BPA0.70676437
70PNCK0.70565653
71TTK0.70054108
72MAP2K70.69079213
73CDK180.67641440
74CSNK1G10.65653954
75SGK30.65598035
76LIMK10.64835952
77TESK10.64773415
78ILK0.63731196
79FGFR10.63323507
80WNK30.62249787
81CDK11A0.61581471
82TAF10.61343138
83ERBB40.61209571
84RPS6KC10.61054519
85RPS6KL10.61054519
86MAPK120.60063251
87PRKD10.59394136
88WNK40.59226841
89BMX0.58540308
90PRKAA10.57817105
91PRPF4B0.57686713
92ERBB20.57291454
93PRKCG0.57220459
94DYRK1A0.55958037
95FYN0.55534975
96DDR20.55168254
97NEK20.54736825
98MTOR0.54566012
99EEF2K0.53856650
100AKT20.53806982
101PTK20.53677912
102HIPK20.53585725
103CASK0.52790732
104LATS10.51893974
105WEE10.51490202
106PDGFRB0.51407364
107TNIK0.50217753
108IRAK30.48016393
109CHEK20.47835122
110CAMK2A0.47827616
111GSK3A0.47455903
112SGK20.45683157
113STK380.45155826
114FER0.44722604
115WNK10.44552978
116SGK4940.43706130
117SGK2230.43706130
118NEK10.43395949
119MAP3K70.42857067
120MAPK90.42789921
121ROCK10.42563497
122RPS6KA30.42556038
123CSNK1D0.42505759
124RPS6KA60.42274624
125PDPK10.41445550
126PAK20.41038647
127SGK10.40084700
128TIE10.39103017
129CDK30.38705098
130CDK90.37961367
131MAP3K60.37764735
132RPS6KB20.37610729
133PRKCE0.36039251
134MET0.35903067
135STK390.35681607
136MAPK100.35666957
137RPS6KA10.33390863
138GSK3B0.32417986
139ABL20.32085334
140AKT10.31770886
141CDK10.31573111
142AURKA0.31077644
143ROCK20.28965128
144CDK20.28858617
145MAPKAPK30.28379456
146CDK40.28372444
147CSNK1E0.27995808

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045121.99356015
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93477440
3Circadian entrainment_Homo sapiens_hsa047131.93431208
4Adherens junction_Homo sapiens_hsa045201.88493486
5GABAergic synapse_Homo sapiens_hsa047271.87642926
6Axon guidance_Homo sapiens_hsa043601.87304423
7Type II diabetes mellitus_Homo sapiens_hsa049301.81693656
8Notch signaling pathway_Homo sapiens_hsa043301.79087106
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77028715
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75625490
11Dopaminergic synapse_Homo sapiens_hsa047281.74565651
12Glutamatergic synapse_Homo sapiens_hsa047241.73909943
13Insulin secretion_Homo sapiens_hsa049111.68583365
14Cholinergic synapse_Homo sapiens_hsa047251.65956224
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64593714
16Synaptic vesicle cycle_Homo sapiens_hsa047211.63548118
17Long-term potentiation_Homo sapiens_hsa047201.62438382
18Olfactory transduction_Homo sapiens_hsa047401.59945532
19Morphine addiction_Homo sapiens_hsa050321.59613336
20Cocaine addiction_Homo sapiens_hsa050301.54394058
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54198276
22Vitamin B6 metabolism_Homo sapiens_hsa007501.52094045
23Butanoate metabolism_Homo sapiens_hsa006501.49861315
24Nicotine addiction_Homo sapiens_hsa050331.48561909
25Thyroid cancer_Homo sapiens_hsa052161.47458551
26Amphetamine addiction_Homo sapiens_hsa050311.46368152
27Gap junction_Homo sapiens_hsa045401.45554319
28Tyrosine metabolism_Homo sapiens_hsa003501.44559747
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43758553
30Renin secretion_Homo sapiens_hsa049241.37952967
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37839372
32MicroRNAs in cancer_Homo sapiens_hsa052061.34736776
33Estrogen signaling pathway_Homo sapiens_hsa049151.34470555
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.33980129
35Dilated cardiomyopathy_Homo sapiens_hsa054141.33583611
36Gastric acid secretion_Homo sapiens_hsa049711.29183745
37Endometrial cancer_Homo sapiens_hsa052131.27826125
38Oxytocin signaling pathway_Homo sapiens_hsa049211.25425336
39Proteoglycans in cancer_Homo sapiens_hsa052051.23371864
40Biosynthesis of amino acids_Homo sapiens_hsa012301.21784231
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18931397
42Salivary secretion_Homo sapiens_hsa049701.18043307
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17208871
44Bladder cancer_Homo sapiens_hsa052191.15891187
45Glioma_Homo sapiens_hsa052141.15566701
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.15452993
47Nitrogen metabolism_Homo sapiens_hsa009101.13649133
48Long-term depression_Homo sapiens_hsa047301.13155302
49Prostate cancer_Homo sapiens_hsa052151.11331796
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11239452
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.09932981
52Renal cell carcinoma_Homo sapiens_hsa052111.09537928
53GnRH signaling pathway_Homo sapiens_hsa049121.09408670
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07276496
55ErbB signaling pathway_Homo sapiens_hsa040121.06655005
56Melanogenesis_Homo sapiens_hsa049161.05707195
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04392706
58Melanoma_Homo sapiens_hsa052181.04201570
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04185141
60mTOR signaling pathway_Homo sapiens_hsa041501.03569937
61Small cell lung cancer_Homo sapiens_hsa052221.03195759
62Fatty acid biosynthesis_Homo sapiens_hsa000610.99724246
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.99447814
64Taste transduction_Homo sapiens_hsa047420.99335601
65cAMP signaling pathway_Homo sapiens_hsa040240.98757029
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98675306
67Serotonergic synapse_Homo sapiens_hsa047260.98015912
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97762434
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97471166
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95234381
71Protein digestion and absorption_Homo sapiens_hsa049740.94662349
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94538618
73Dorso-ventral axis formation_Homo sapiens_hsa043200.93970634
74Insulin signaling pathway_Homo sapiens_hsa049100.93449506
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90582621
76Colorectal cancer_Homo sapiens_hsa052100.90012301
77Cardiac muscle contraction_Homo sapiens_hsa042600.86953615
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85581351
79Bile secretion_Homo sapiens_hsa049760.84462631
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84422607
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.84120196
82Hedgehog signaling pathway_Homo sapiens_hsa043400.83886931
83Insulin resistance_Homo sapiens_hsa049310.83426759
84Calcium signaling pathway_Homo sapiens_hsa040200.83102058
85AMPK signaling pathway_Homo sapiens_hsa041520.82955199
86Basal cell carcinoma_Homo sapiens_hsa052170.82909286
87Glucagon signaling pathway_Homo sapiens_hsa049220.82884277
88Pathways in cancer_Homo sapiens_hsa052000.82733057
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.82240406
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80781270
91Galactose metabolism_Homo sapiens_hsa000520.77433019
92Arginine biosynthesis_Homo sapiens_hsa002200.77314712
93Hippo signaling pathway_Homo sapiens_hsa043900.77099770
94PPAR signaling pathway_Homo sapiens_hsa033200.76052201
95Pancreatic secretion_Homo sapiens_hsa049720.75952643
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75889967
97TGF-beta signaling pathway_Homo sapiens_hsa043500.75280650
98VEGF signaling pathway_Homo sapiens_hsa043700.75274428
99Tight junction_Homo sapiens_hsa045300.74639803
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.74062583
101Phenylalanine metabolism_Homo sapiens_hsa003600.73523704
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.72978407
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71752634
104Prion diseases_Homo sapiens_hsa050200.71562415
105Viral myocarditis_Homo sapiens_hsa054160.71121209
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70791965
107Vibrio cholerae infection_Homo sapiens_hsa051100.70162750
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69250896
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68765421
110Amoebiasis_Homo sapiens_hsa051460.68298077
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67776019
112Choline metabolism in cancer_Homo sapiens_hsa052310.66588578
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66515799
114Fructose and mannose metabolism_Homo sapiens_hsa000510.66185517
115Lysine degradation_Homo sapiens_hsa003100.65536776
116Pentose phosphate pathway_Homo sapiens_hsa000300.65309586
117Wnt signaling pathway_Homo sapiens_hsa043100.65220464
118Non-small cell lung cancer_Homo sapiens_hsa052230.64825061
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64750294
120Carbon metabolism_Homo sapiens_hsa012000.63943920
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.62924032
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62135116
123Thyroid hormone synthesis_Homo sapiens_hsa049180.60357040
124Steroid biosynthesis_Homo sapiens_hsa001000.59795859
125Pyruvate metabolism_Homo sapiens_hsa006200.59432509
126MAPK signaling pathway_Homo sapiens_hsa040100.58870355
127Fatty acid metabolism_Homo sapiens_hsa012120.58282305
128Arginine and proline metabolism_Homo sapiens_hsa003300.58132487
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57981368
130Rap1 signaling pathway_Homo sapiens_hsa040150.57537278
131Focal adhesion_Homo sapiens_hsa045100.56387937
132Pancreatic cancer_Homo sapiens_hsa052120.56343634
133mRNA surveillance pathway_Homo sapiens_hsa030150.56121844
134Endocytosis_Homo sapiens_hsa041440.54634973
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54471713
136Ras signaling pathway_Homo sapiens_hsa040140.53813427
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53653608
138Oocyte meiosis_Homo sapiens_hsa041140.53408719
139Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53306059
140Inositol phosphate metabolism_Homo sapiens_hsa005620.53166677
141Sulfur relay system_Homo sapiens_hsa041220.52099560
142Chronic myeloid leukemia_Homo sapiens_hsa052200.51710943
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.50087840
144Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49026852
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48697110

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