TBC1D17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)6.02819478
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.25791882
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.25791882
4positive regulation of gamma-delta T cell activation (GO:0046645)4.92378287
5NIK/NF-kappaB signaling (GO:0038061)4.83729297
6regulation of interleukin-12 biosynthetic process (GO:0045075)4.70602905
7negative regulation of cell killing (GO:0031342)4.49945148
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.49945148
9positive regulation of B cell differentiation (GO:0045579)4.43159957
10mature B cell differentiation (GO:0002335)4.20952254
11negative regulation of erythrocyte differentiation (GO:0045647)4.04461362
12mature B cell differentiation involved in immune response (GO:0002313)4.00006698
13positive regulation of antigen processing and presentation (GO:0002579)3.86846812
14growth hormone receptor signaling pathway (GO:0060396)3.79279906
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.62512385
16oxaloacetate metabolic process (GO:0006107)3.60479734
17T-helper 1 type immune response (GO:0042088)3.53251697
18valine metabolic process (GO:0006573)3.52192381
19regulation of gamma-delta T cell differentiation (GO:0045586)3.50897793
20ribosomal small subunit assembly (GO:0000028)3.50218146
21cellular response to growth hormone stimulus (GO:0071378)3.47677088
22negative regulation of granulocyte differentiation (GO:0030853)3.45498264
23regulation of gamma-delta T cell activation (GO:0046643)3.43086597
24regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.39430352
25regulation of antigen processing and presentation (GO:0002577)3.37539117
26antigen processing and presentation via MHC class Ib (GO:0002475)3.37126686
27regulation of dendritic cell antigen processing and presentation (GO:0002604)3.36188235
28oxidative demethylation (GO:0070989)3.30967048
29regulation of B cell differentiation (GO:0045577)3.27557179
30DNA deamination (GO:0045006)3.22619922
31response to muramyl dipeptide (GO:0032495)3.19226197
32B cell receptor signaling pathway (GO:0050853)3.13718484
33myeloid dendritic cell differentiation (GO:0043011)3.13581003
34tricarboxylic acid metabolic process (GO:0072350)3.05053330
35myeloid dendritic cell activation (GO:0001773)3.03492774
36negative regulation of myotube differentiation (GO:0010832)3.03233646
37JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.97010279
38DNA demethylation (GO:0080111)2.95856757
39regulation of granulocyte differentiation (GO:0030852)2.93898501
40viral protein processing (GO:0019082)2.92483490
41negative regulation of glycoprotein biosynthetic process (GO:0010561)2.89304028
42serine transport (GO:0032329)2.87132682
43NADH metabolic process (GO:0006734)2.85215862
44germinal center formation (GO:0002467)2.82577598
45negative regulation of nitric-oxide synthase activity (GO:0051001)2.82327882
46dendritic cell differentiation (GO:0097028)2.81035392
47regulation of monocyte differentiation (GO:0045655)2.78359667
48macrophage activation involved in immune response (GO:0002281)2.76162984
49regulation of interferon-beta biosynthetic process (GO:0045357)2.75122591
50L-phenylalanine metabolic process (GO:0006558)2.74981315
51erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.74981315
52positive regulation of natural killer cell differentiation (GO:0032825)2.73973989
53positive regulation of cholesterol efflux (GO:0010875)2.73037482
54activation of MAPKKK activity (GO:0000185)2.72404198
55positive regulation of histone deacetylation (GO:0031065)2.71271111
56sexual reproduction (GO:0019953)2.71216465
57response to interferon-beta (GO:0035456)2.65518468
58peroxisomal transport (GO:0043574)2.65247970
59regulation of cholesterol efflux (GO:0010874)2.65107969
60defense response to protozoan (GO:0042832)2.64614895
61nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.64391070
62type I interferon signaling pathway (GO:0060337)2.63082569
63cellular response to type I interferon (GO:0071357)2.63082569
64regulation of cholesterol esterification (GO:0010872)2.62918788
65cellular response to zinc ion (GO:0071294)2.62837558
66response to type I interferon (GO:0034340)2.59959368
67pyrimidine nucleoside salvage (GO:0043097)2.59149238
68pyrimidine-containing compound salvage (GO:0008655)2.59149238
69modulation by symbiont of host defense response (GO:0052031)2.58277339
70modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.58277339
71modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.58277339
72positive regulation by organism of defense response of other organism involved in symbiotic interact2.58277339
73modulation by symbiont of host immune response (GO:0052553)2.58277339
74positive regulation by symbiont of host defense response (GO:0052509)2.58277339
75immunoglobulin mediated immune response (GO:0016064)2.57970368
76amyloid precursor protein catabolic process (GO:0042987)2.57877481
77mannose metabolic process (GO:0006013)2.56964663
78negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.56754886
79positive regulation of interleukin-2 production (GO:0032743)2.55792749
80regulation of ARF protein signal transduction (GO:0032012)2.55121284
81positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.54779632
82viral transcription (GO:0019083)2.54709081
83mitochondrial calcium ion transport (GO:0006851)2.52970523
84negative regulation of innate immune response (GO:0045824)2.52235411
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.50484113
86signal complex assembly (GO:0007172)2.50480095
87positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.50181257
88positive regulation of interleukin-12 production (GO:0032735)2.49848431
89barbed-end actin filament capping (GO:0051016)2.49126026
90Peyers patch development (GO:0048541)2.48509767
91mucosal-associated lymphoid tissue development (GO:0048537)2.48509767
92positive regulation of Rap GTPase activity (GO:0032854)2.47482621
93branched-chain amino acid metabolic process (GO:0009081)2.47154239
94cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.46980637
95protein targeting to peroxisome (GO:0006625)2.46935654
96establishment of protein localization to peroxisome (GO:0072663)2.46935654
97protein localization to peroxisome (GO:0072662)2.46935654
98regulation of T-helper 2 cell differentiation (GO:0045628)2.46795207
99thymic T cell selection (GO:0045061)2.44470694
100negative regulation of lymphocyte mediated immunity (GO:0002707)2.43096209
101positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.43063051
102positive regulation of granulocyte differentiation (GO:0030854)2.42906215
103interferon-gamma-mediated signaling pathway (GO:0060333)2.42684325
104phospholipid efflux (GO:0033700)2.42656156
105negative regulation of glycoprotein metabolic process (GO:1903019)2.42554013
106positive thymic T cell selection (GO:0045059)2.42263061
107regulation of B cell receptor signaling pathway (GO:0050855)2.41993917
108DNA dealkylation (GO:0035510)2.40893655
109regulation of relaxation of muscle (GO:1901077)2.40778642
110regulation of apoptotic cell clearance (GO:2000425)2.40556488
111peptidyl-tyrosine autophosphorylation (GO:0038083)2.40201880
112metallo-sulfur cluster assembly (GO:0031163)2.38677757
113iron-sulfur cluster assembly (GO:0016226)2.38677757
114negative regulation of leukocyte mediated immunity (GO:0002704)2.37822112
115cellular response to interferon-beta (GO:0035458)2.35663951
116regulation of T-helper 1 cell differentiation (GO:0045625)2.34589100
117negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.34541195
118erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.34118856
119L-phenylalanine catabolic process (GO:0006559)2.34118856
120positive regulation of B cell proliferation (GO:0030890)2.33616993
121regulation of ARF GTPase activity (GO:0032312)2.33379777
122synaptic vesicle docking involved in exocytosis (GO:0016081)2.32913953
123negative thymic T cell selection (GO:0045060)2.32747289
124regulation of T cell mediated cytotoxicity (GO:0001914)2.29562208
125regulation of type I interferon-mediated signaling pathway (GO:0060338)2.26981635
126detection of bacterium (GO:0016045)2.26502238
127negative regulation of type 2 immune response (GO:0002829)2.24884627
128negative regulation of interleukin-12 production (GO:0032695)2.24582901
129synaptic vesicle exocytosis (GO:0016079)2.22247321
130negative regulation of cytokine production involved in immune response (GO:0002719)2.20728196
131regulation of type 2 immune response (GO:0002828)2.19067107
132response to peptidoglycan (GO:0032494)2.18822977
133cellular response to virus (GO:0098586)2.17662541
134positive regulation of type 2 immune response (GO:0002830)2.17304179
135detection of other organism (GO:0098543)2.14735087
136tolerance induction (GO:0002507)2.14496608
137T cell selection (GO:0045058)2.13720587
138negative regulation of T cell mediated immunity (GO:0002710)2.13700531
139modulation by symbiont of host cellular process (GO:0044068)2.11406347
140positive regulation of synapse maturation (GO:0090129)2.11232499
141positive regulation of protein deacetylation (GO:0090312)2.08476586
142regulation of extracellular matrix disassembly (GO:0010715)2.08467817
143regulation of necroptotic process (GO:0060544)2.08237418
144creatine metabolic process (GO:0006600)2.08077136
145regulation of mast cell degranulation (GO:0043304)2.05738362
146modulation by virus of host process (GO:0019054)2.04446584
147regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.04410293
148regulation of natural killer cell mediated immunity (GO:0002715)2.04410293
149regulation of defense response to virus by virus (GO:0050690)2.03402961
150positive regulation of protein dephosphorylation (GO:0035307)1.99142436
151positive regulation of interleukin-2 biosynthetic process (GO:0045086)1.98990493
152regulation of Rap GTPase activity (GO:0032317)1.98820703
153regulation of leukocyte degranulation (GO:0043300)1.98042974
154lipopolysaccharide-mediated signaling pathway (GO:0031663)1.97491947
155negative regulation of cell size (GO:0045792)1.96784591
156regulation of myeloid leukocyte mediated immunity (GO:0002886)1.96521254
157leukocyte aggregation (GO:0070486)1.96394525
158regulation of T cell tolerance induction (GO:0002664)1.96094153
159adhesion of symbiont to host cell (GO:0044650)1.95951391
160virion attachment to host cell (GO:0019062)1.95951391
161positive regulation of T cell mediated cytotoxicity (GO:0001916)1.95305585
162positive regulation of Cdc42 GTPase activity (GO:0043089)1.94156895
163negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)1.93205181
164positive regulation of receptor recycling (GO:0001921)1.91599033
165synaptic vesicle maturation (GO:0016188)1.90166621
166positive regulation of CREB transcription factor activity (GO:0032793)1.90003527
167regulation of histone deacetylation (GO:0031063)1.89932059
168response to protozoan (GO:0001562)1.89742040

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.56245424
2VDR_21846776_ChIP-Seq_THP-1_Human3.00628925
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95426048
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.72351338
5SCL_19346495_ChIP-Seq_HPC-7_Human2.70556913
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.69251462
7MYC_22102868_ChIP-Seq_BL_Human2.61967028
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42587105
9E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.41529305
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38819569
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30027683
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.24335460
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20920322
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.15874509
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15852137
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.14305445
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11806361
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.10310269
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.09955604
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05276788
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01231441
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00245850
23MAF_26560356_Chip-Seq_TH1_Human1.97957516
24LXR_22292898_ChIP-Seq_THP-1_Human1.90315828
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90088871
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.85041295
27LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84567569
28GATA1_19941827_ChIP-Seq_MEL_Mouse1.82373129
29KDM2B_26808549_Chip-Seq_K562_Human1.81188763
30BCL6_27268052_Chip-Seq_Bcells_Human1.80740886
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79174962
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78716529
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77475215
34DROSHA_22980978_ChIP-Seq_HELA_Human1.77113615
35GATA1_22383799_ChIP-Seq_G1ME_Mouse1.75074971
36LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.71537581
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70266579
38CIITA_25753668_ChIP-Seq_RAJI_Human1.68559775
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.68243018
40RACK7_27058665_Chip-Seq_MCF-7_Human1.67697874
41GATA1_22025678_ChIP-Seq_K562_Human1.67551164
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.66010737
43VDR_24763502_ChIP-Seq_THP-1_Human1.64949907
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63699962
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.63049715
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.62423327
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62163856
48SMC4_20622854_ChIP-Seq_HELA_Human1.60370674
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.60060397
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56761380
51UTX_26944678_Chip-Seq_JUKART_Human1.55489535
52TCF7_22412390_ChIP-Seq_EML_Mouse1.55169952
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.55143860
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.53702248
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.53221238
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52429256
57MAF_26560356_Chip-Seq_TH2_Human1.51057579
58ZNF263_19887448_ChIP-Seq_K562_Human1.49685615
59* SPI1_23547873_ChIP-Seq_NB4_Human1.49499968
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49409740
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48983734
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47221336
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47163915
64CTCF_27219007_Chip-Seq_Bcells_Human1.46511894
65BCOR_27268052_Chip-Seq_Bcells_Human1.46438258
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.45763594
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.44411640
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.42414405
69GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42363751
70KDM2B_26808549_Chip-Seq_DND41_Human1.39967564
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.39707103
72RUNX_20019798_ChIP-Seq_JUKART_Human1.36298904
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35383624
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35357115
75SPI1_23127762_ChIP-Seq_K562_Human1.34605644
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34283083
77P68_20966046_ChIP-Seq_HELA_Human1.33751385
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33141296
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.32851350
80DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31992931
81RUNX1_22412390_ChIP-Seq_EML_Mouse1.29303753
82* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28638310
83CTCF_21964334_ChIP-Seq_BJAB-B_Human1.28093648
84* SRF_21415370_ChIP-Seq_HL-1_Mouse1.27472759
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27141021
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.27074923
87CREB1_26743006_Chip-Seq_LNCaP_Human1.26846717
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.25880789
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25594373
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24826984
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24634378
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24058750
93YY1_22570637_ChIP-Seq_MALME-3M_Human1.23067724
94* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23013700
95MYB_26560356_Chip-Seq_TH1_Human1.21757627
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21630203
97SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21444313
98SA1_27219007_Chip-Seq_ERYTHROID_Human1.20847802
99FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20637737
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20564547
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17180919
102JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16776205
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15769887
104OCT4_19829295_ChIP-Seq_ESCs_Human1.15697455
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15571745
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15397065
107EZH2_27294783_Chip-Seq_ESCs_Mouse1.13871094
108CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12638056
109SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11432682
110TP63_22573176_ChIP-Seq_HFKS_Human1.11396106
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11204829
112RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11131172
113ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10805535
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09705569
115BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08993090
116EGR1_19374776_ChIP-ChIP_THP-1_Human1.07862294
117PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07328880
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07321904
119E2F1_20622854_ChIP-Seq_HELA_Human1.07217707
120CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06703640
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06245463
122P300_27268052_Chip-Seq_Bcells_Human1.06229230
123TFEB_21752829_ChIP-Seq_HELA_Human1.05817079
124SA1_27219007_Chip-Seq_Bcells_Human1.05734496
125PHF8_20622854_ChIP-Seq_HELA_Human1.04218906
126* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03644334
127TP63_17297297_ChIP-ChIP_HaCaT_Human1.03241166
128CTCF_21964334_Chip-Seq_Bcells_Human1.02558926
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02330091
130GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01412402
131SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00194833
132MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00143934
133YY1_21170310_ChIP-Seq_MESCs_Mouse1.00083867
134GATA1_19941826_ChIP-Seq_K562_Human0.99930681
135RARB_27405468_Chip-Seq_BRAIN_Mouse0.99683942
136TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99586013
137NCOR1_26117541_ChIP-Seq_K562_Human0.98462372
138TP53_22127205_ChIP-Seq_IMR90_Human0.98177885
139* CTCF_20526341_ChIP-Seq_ESCs_Human0.97545317
140RARB_24833708_ChIP-Seq_LIVER_Mouse0.97428776
141TET1_21490601_ChIP-Seq_MESCs_Mouse0.97065701
142MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96582123

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system4.99658666
2MP0001835_abnormal_antigen_presentation4.00437358
3MP0000685_abnormal_immune_system3.84544213
4MP0002254_reproductive_system_inflammat3.33782848
5MP0005671_abnormal_response_to2.93478258
6MP0001790_abnormal_immune_system2.83799260
7MP0005387_immune_system_phenotype2.83799260
8MP0009840_abnormal_foam_cell2.74975198
9MP0001800_abnormal_humoral_immune2.68298782
10MP0005058_abnormal_lysosome_morphology2.44172361
11MP0002452_abnormal_antigen_presenting2.40188936
12MP0004510_myositis2.31473694
13MP0001348_abnormal_lacrimal_gland2.26641071
14MP0004859_abnormal_synaptic_plasticity2.25081075
15MP0002723_abnormal_immune_serum2.15763622
16MP0002148_abnormal_hypersensitivity_rea2.06735567
17MP0001873_stomach_inflammation2.01313565
18MP0002420_abnormal_adaptive_immunity1.99249663
19MP0001819_abnormal_immune_cell1.98332188
20MP0005075_abnormal_melanosome_morpholog1.95166558
21MP0002419_abnormal_innate_immunity1.94684995
22MP0005451_abnormal_body_composition1.94636162
23MP0005000_abnormal_immune_tolerance1.89547825
24MP0005025_abnormal_response_to1.88376174
25MP0005365_abnormal_bile_salt1.88195485
26MP0003329_amyloid_beta_deposits1.87856413
27MP0003879_abnormal_hair_cell1.86967802
28MP0003436_decreased_susceptibility_to1.84476853
29MP0003300_gastrointestinal_ulcer1.81754850
30MP0000751_myopathy1.79152466
31MP0009785_altered_susceptibility_to1.77537660
32MP0003690_abnormal_glial_cell1.76619049
33MP0001986_abnormal_taste_sensitivity1.75714107
34MP0005083_abnormal_biliary_tract1.71117573
35MP0004858_abnormal_nervous_system1.69573164
36MP0002398_abnormal_bone_marrow1.69301417
37MP0005310_abnormal_salivary_gland1.69176912
38MP0000716_abnormal_immune_system1.65474739
39MP0005464_abnormal_platelet_physiology1.63488292
40MP0004947_skin_inflammation1.63303517
41MP0000604_amyloidosis1.60984110
42MP0009278_abnormal_bone_marrow1.57690402
43MP0003172_abnormal_lysosome_physiology1.55349043
44MP0000689_abnormal_spleen_morphology1.54684097
45MP0008260_abnormal_autophagy1.53310442
46MP0003656_abnormal_erythrocyte_physiolo1.52940991
47MP0003303_peritoneal_inflammation1.47976494
48MP0004130_abnormal_muscle_cell1.47956888
49MP0003075_altered_response_to1.46918584
50MP0002722_abnormal_immune_system1.45016195
51MP0003191_abnormal_cellular_cholesterol1.43975937
52MP0002429_abnormal_blood_cell1.43516513
53MP0001853_heart_inflammation1.40720870
54MP0003763_abnormal_thymus_physiology1.39902813
55MP0003866_abnormal_defecation1.36488338
56MP0000749_muscle_degeneration1.33941679
57MP0004145_abnormal_muscle_electrophysio1.31866260
58MP0005167_abnormal_blood-brain_barrier1.28925081
59MP0001764_abnormal_homeostasis1.27290183
60MP0003724_increased_susceptibility_to1.26394014
61MP0005174_abnormal_tail_pigmentation1.26375317
62MP0001845_abnormal_inflammatory_respons1.25153832
63MP0002998_abnormal_bone_remodeling1.24579334
64MP0008469_abnormal_protein_level1.24212073
65MP0008961_abnormal_basal_metabolism1.23387831
66MP0008569_lethality_at_weaning1.22162307
67MP0003705_abnormal_hypodermis_morpholog1.21740858
68MP0003279_aneurysm1.21301984
69MP0001958_emphysema1.20486642
70MP0000920_abnormal_myelination1.20050638
71MP0008874_decreased_physiological_sensi1.16512216
72MP0006036_abnormal_mitochondrial_physio1.16443628
73MP0002396_abnormal_hematopoietic_system1.13309796
74MP0009764_decreased_sensitivity_to1.13054462
75MP0001501_abnormal_sleep_pattern1.12923561
76MP0000747_muscle_weakness1.12724243
77MP0002139_abnormal_hepatobiliary_system1.09360095
78MP0002332_abnormal_exercise_endurance1.08114228
79MP0005332_abnormal_amino_acid1.07709731
80MP0005584_abnormal_enzyme/coenzyme_acti1.07647517
81MP0005670_abnormal_white_adipose1.07484424
82MP0003045_fibrosis1.07316765
83MP0010329_abnormal_lipoprotein_level1.07095698
84MP0010155_abnormal_intestine_physiology1.05626581
85MP0002405_respiratory_system_inflammati1.02892552
86MP0000013_abnormal_adipose_tissue1.02049853
87MP0005166_decreased_susceptibility_to1.00149633
88MP0003635_abnormal_synaptic_transmissio0.99802234
89MP0000703_abnormal_thymus_morphology0.98840950
90MP0005423_abnormal_somatic_nervous0.95945611
91MP0006082_CNS_inflammation0.94751295
92MP0000465_gastrointestinal_hemorrhage0.94502713
93MP0002064_seizures0.94278971
94MP0000343_altered_response_to0.92494527
95MP0000759_abnormal_skeletal_muscle0.91056726
96MP0005390_skeleton_phenotype0.91004230
97MP0001270_distended_abdomen0.90965509
98MP0002132_abnormal_respiratory_system0.90774727
99MP0003646_muscle_fatigue0.90348099
100MP0000750_abnormal_muscle_regeneration0.89176566
101MP0002933_joint_inflammation0.89102099
102MP0005535_abnormal_body_temperature0.88430710
103MP0002063_abnormal_learning/memory/cond0.87573122
104MP0005666_abnormal_adipose_tissue0.87448436
105MP0001346_abnormal_lacrimal_gland0.86156743
106MP0009333_abnormal_splenocyte_physiolog0.86127611
107MP0000003_abnormal_adipose_tissue0.85363851
108MP0003183_abnormal_peptide_metabolism0.84389091
109MP0009765_abnormal_xenobiotic_induced0.83725923
110MP0002118_abnormal_lipid_homeostasis0.83684233
111MP0009643_abnormal_urine_homeostasis0.83583217
112MP0005397_hematopoietic_system_phenotyp0.80383902
113MP0001545_abnormal_hematopoietic_system0.80383902
114MP0001879_abnormal_lymphatic_vessel0.79287239
115MP0000609_abnormal_liver_physiology0.78063721
116MP0001663_abnormal_digestive_system0.77265367
117MP0003011_delayed_dark_adaptation0.76254834
118MP0000858_altered_metastatic_potential0.74429869
119MP0002166_altered_tumor_susceptibility0.74147572
120MP0004270_analgesia0.74129820
121MP0002106_abnormal_muscle_physiology0.72381393
122MP0001502_abnormal_circadian_rhythm0.71926137
123MP0005645_abnormal_hypothalamus_physiol0.70885053
124MP0005334_abnormal_fat_pad0.70868086
125MP0001542_abnormal_bone_strength0.69356958
126MP0000249_abnormal_blood_vessel0.68966350
127MP0003091_abnormal_cell_migration0.68614467
128MP0000598_abnormal_liver_morphology0.68277852
129MP0009763_increased_sensitivity_to0.67760592
130MP0002822_catalepsy0.67547979
131MP0003959_abnormal_lean_body0.67462929
132MP0002909_abnormal_adrenal_gland0.67440967
133MP0003828_pulmonary_edema0.67375174
134MP0001970_abnormal_pain_threshold0.66746884
135MP0009745_abnormal_behavioral_response0.66642939
136MP0002971_abnormal_brown_adipose0.66568189
137MP0006035_abnormal_mitochondrial_morpho0.65972743
138MP0009642_abnormal_blood_homeostasis0.65933509
139MP0001533_abnormal_skeleton_physiology0.65909958
140MP0002136_abnormal_kidney_physiology0.65801540
141MP0002653_abnormal_ependyma_morphology0.65630064
142MP0005319_abnormal_enzyme/_coenzyme0.65184782
143MP0005375_adipose_tissue_phenotype0.63873953
144MP0004142_abnormal_muscle_tone0.63166801
145MP0004808_abnormal_hematopoietic_stem0.63121809

Predicted human phenotypes

RankGene SetZ-score
1Ragged-red muscle fibers (HP:0003200)4.04725040
2Agammaglobulinemia (HP:0004432)3.99062378
3Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.89679741
4Decreased activity of mitochondrial respiratory chain (HP:0008972)3.89679741
5Facial diplegia (HP:0001349)3.81279413
6Obstructive sleep apnea (HP:0002870)3.70476481
7Progressive inability to walk (HP:0002505)3.56297825
8Chronic otitis media (HP:0000389)3.51152399
9Thrombocytosis (HP:0001894)3.46877504
10Gastrointestinal stroma tumor (HP:0100723)3.36302033
11Failure to thrive in infancy (HP:0001531)3.09132888
12Exercise-induced myalgia (HP:0003738)3.08789601
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.08596126
14Gastrointestinal inflammation (HP:0004386)3.04687002
15Fatigue (HP:0012378)3.04205679
16Type 1 muscle fiber predominance (HP:0003803)3.03464890
17Supranuclear gaze palsy (HP:0000605)2.95314172
18Inflammation of the large intestine (HP:0002037)2.94235361
19Systemic lupus erythematosus (HP:0002725)2.87871541
20Recurrent fungal infections (HP:0002841)2.87537468
21Recurrent bronchitis (HP:0002837)2.84790273
22Myositis (HP:0100614)2.81352586
23Abnormality of the heme biosynthetic pathway (HP:0010472)2.80096423
24Interstitial pulmonary disease (HP:0006530)2.79052023
25Abnormality of the nasal mucosa (HP:0000433)2.78353823
26Increased variability in muscle fiber diameter (HP:0003557)2.75836223
27Panhypogammaglobulinemia (HP:0003139)2.75247274
28Neurofibrillary tangles (HP:0002185)2.73498494
29Abnormality of glycolipid metabolism (HP:0010969)2.72926677
30Abnormality of liposaccharide metabolism (HP:0010968)2.72926677
31Abnormality of glycosphingolipid metabolism (HP:0004343)2.72926677
32Abnormality of binocular vision (HP:0011514)2.72017492
33Diplopia (HP:0000651)2.72017492
34Dysostosis multiplex (HP:0000943)2.71230500
35Orchitis (HP:0100796)2.70709673
36Vacuolated lymphocytes (HP:0001922)2.70316522
37Chronic mucocutaneous candidiasis (HP:0002728)2.69946422
38Recurrent cutaneous fungal infections (HP:0011370)2.69946422
39Colitis (HP:0002583)2.65420277
40Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.62251668
41Abnormality of skeletal muscle fiber size (HP:0012084)2.60894566
42Poikiloderma (HP:0001029)2.59947951
43Recurrent viral infections (HP:0004429)2.59656572
44Recurrent gram-negative bacterial infections (HP:0005420)2.59287051
45Abnormality of aromatic amino acid family metabolism (HP:0004338)2.57495464
46Increased connective tissue (HP:0009025)2.51066941
47Recurrent skin infections (HP:0001581)2.42332598
48Emphysema (HP:0002097)2.42262361
49Epistaxis (HP:0000421)2.41089267
50Ankle clonus (HP:0011448)2.40483543
51Chronic sinusitis (HP:0011109)2.39734398
52Muscle fiber splitting (HP:0003555)2.39221856
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.37508307
54Stomatitis (HP:0010280)2.37214019
55Prolonged bleeding time (HP:0003010)2.35650466
56Distal lower limb muscle weakness (HP:0009053)2.34798341
57Vertebral compression fractures (HP:0002953)2.33922747
58Petechiae (HP:0000967)2.33489071
59Cellulitis (HP:0100658)2.31349211
60Spontaneous hematomas (HP:0007420)2.30266943
61Loss of speech (HP:0002371)2.30045993
62Nasal polyposis (HP:0100582)2.29011062
63Optic neuritis (HP:0100653)2.26858317
64Retrobulbar optic neuritis (HP:0100654)2.26858317
65Myopathic facies (HP:0002058)2.25916458
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.25836842
67Abnormality of polysaccharide metabolism (HP:0011012)2.25836842
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.25836842
69Neutropenia (HP:0001875)2.24142358
70Neuronal loss in central nervous system (HP:0002529)2.23883085
71Axonal loss (HP:0003447)2.23175265
72Stridor (HP:0010307)2.20589089
73Aplastic anemia (HP:0001915)2.20198799
74Opisthotonus (HP:0002179)2.17714965
75Abnormality of macrophages (HP:0004311)2.17714240
76Abnormal rod and cone electroretinograms (HP:0008323)2.17148487
77Muscle fiber inclusion bodies (HP:0100299)2.16962601
78Polycythemia (HP:0001901)2.16331396
79Easy fatigability (HP:0003388)2.15812592
80Gastrointestinal infarctions (HP:0005244)2.15613035
81Recurrent bacterial skin infections (HP:0005406)2.15131351
82Bulbar palsy (HP:0001283)2.14672051
83Round ear (HP:0100830)2.14502192
84Late onset (HP:0003584)2.13734309
85Gingivitis (HP:0000230)2.12041170
86Abnormality of cells of the lymphoid lineage (HP:0012140)2.11117943
87Cerebral inclusion bodies (HP:0100314)2.10767259
88Hyperacusis (HP:0010780)2.10601402
89J-shaped sella turcica (HP:0002680)2.10355588
90Lymphopenia (HP:0001888)2.07424038
91Mediastinal lymphadenopathy (HP:0100721)2.05759535
92Distal lower limb amyotrophy (HP:0008944)2.04274103
93Ulnar deviation of the wrist (HP:0003049)2.04015478
94Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.03424885
95Difficulty running (HP:0009046)2.03339673
96Mucopolysacchariduria (HP:0008155)2.03211204
97Urinary glycosaminoglycan excretion (HP:0003541)2.03211204
98Abnormality of DNA repair (HP:0003254)2.03198545
99Restrictive lung disease (HP:0002091)2.03098523
100IgM deficiency (HP:0002850)2.03009965
101Oligomenorrhea (HP:0000876)2.02258560
102Purpura (HP:0000979)2.02123344
103Mildly elevated creatine phosphokinase (HP:0008180)2.01117346
104Elevated erythrocyte sedimentation rate (HP:0003565)2.00717779
105Visual hallucinations (HP:0002367)2.00632837
106Amyloidosis (HP:0011034)2.00237647
107Nemaline bodies (HP:0003798)1.99932024
108Brushfield spots (HP:0001088)1.99908392
109Cerebral aneurysm (HP:0004944)1.99261207
110Cerebral palsy (HP:0100021)1.99198403
111Papilledema (HP:0001085)1.98259422
112Hemorrhage of the eye (HP:0011885)1.97054820
113Centrally nucleated skeletal muscle fibers (HP:0003687)1.96744629
114Meningitis (HP:0001287)1.96615447
115Hyporeflexia of lower limbs (HP:0002600)1.93955430
116Prolonged neonatal jaundice (HP:0006579)1.92974564
117Hyperlipoproteinemia (HP:0010980)1.92303266
118Increased cerebral lipofuscin (HP:0011813)1.91977885
119Glomerulonephritis (HP:0000099)1.91797611
120Upper limb amyotrophy (HP:0009129)1.91502881
121Distal upper limb amyotrophy (HP:0007149)1.91502881
122Rapidly progressive (HP:0003678)1.91387204
123Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91385818
124Pustule (HP:0200039)1.90905251
125Recurrent abscess formation (HP:0002722)1.90029338
126Abnormality of fatty-acid metabolism (HP:0004359)1.89618238
127Ketosis (HP:0001946)1.88624494
128Abnormality of B cell number (HP:0010975)1.88469496
129B lymphocytopenia (HP:0010976)1.88469496
130Eczematoid dermatitis (HP:0000976)1.88019960
131EMG: neuropathic changes (HP:0003445)1.87818795
132Verrucae (HP:0200043)1.87549241
133Papilloma (HP:0012740)1.87549241
134Segmental peripheral demyelination/remyelination (HP:0003481)1.87295627
135Increased muscle lipid content (HP:0009058)1.86510725
136Gingival bleeding (HP:0000225)1.86314774
137Diaphragmatic weakness (HP:0009113)1.85783735
138Hypoplasia of the thymus (HP:0000778)1.85427999
139Mutism (HP:0002300)1.84835094
140Hypercortisolism (HP:0001578)1.84724768
141Pulmonary infiltrates (HP:0002113)1.84516875
142Obstructive lung disease (HP:0006536)1.84422186
143Chronic obstructive pulmonary disease (HP:0006510)1.84422186
144Achilles tendon contracture (HP:0001771)1.83538896
145Increased IgE level (HP:0003212)1.83120163
146Death in childhood (HP:0003819)1.83006194
147EMG: myopathic abnormalities (HP:0003458)1.82875342
148Annular pancreas (HP:0001734)1.82312363
149Asymmetric septal hypertrophy (HP:0001670)1.82007369
150Increased neuronal autofluorescent lipopigment (HP:0002074)1.81599149
151Onion bulb formation (HP:0003383)1.81300910
152Vasculitis (HP:0002633)1.81189235
153Inability to walk (HP:0002540)1.78888277
154Autoimmune thrombocytopenia (HP:0001973)1.78468459
155Weak cry (HP:0001612)1.76431211
156Increased serum ferritin (HP:0003281)1.75915835
157Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.75212303
158Congenital stationary night blindness (HP:0007642)1.74828387
159Chest pain (HP:0100749)1.73896498
160Periodontitis (HP:0000704)1.73857192
161Homocystinuria (HP:0002156)1.73541109
162Abnormality of homocysteine metabolism (HP:0010919)1.73541109
163Albinism (HP:0001022)1.73317484
164Joint stiffness (HP:0001387)1.72578340
165Polygenic inheritance (HP:0010982)1.72482750
166Tetraparesis (HP:0002273)1.71495382
167Increased IgM level (HP:0003496)1.71255955
168Abnormal number of erythroid precursors (HP:0012131)1.71126376
169Xanthomatosis (HP:0000991)1.70918915
170Thin bony cortex (HP:0002753)1.70545083
171Pallor (HP:0000980)1.70483539
172Recurrent sinusitis (HP:0011108)1.69923089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.46673100
2MAP3K142.70276441
3BCKDK2.64919614
4TBK12.57442764
5BLK2.38843445
6RIPK42.29569001
7INSRR2.28323121
8TYK22.27775123
9PRPF4B2.27213373
10FGFR42.17107082
11SIK32.14652889
12IKBKB2.07146312
13KIT2.07023564
14ERN12.06757424
15TRIB32.05257048
16IKBKE2.01057331
17MAP3K131.83199043
18JAK31.82673501
19FLT31.80045428
20TLK11.76789087
21TGFBR21.76146989
22PINK11.74610387
23SRPK11.72645437
24IRAK41.68653822
25MAP3K71.65447152
26IRAK31.64103375
27SIK11.58182269
28DAPK21.55912429
29CDC42BPA1.46351080
30MAPK151.45960363
31CHUK1.45339425
32CSF1R1.43276970
33JAK11.41363215
34BTK1.41201148
35EPHB11.39445076
36STK161.37238078
37IRAK11.36480366
38SMG11.35233032
39TAOK21.35185468
40CAMKK11.34440064
41ZAP701.34340370
42SYK1.33663699
43TAOK11.33527936
44TSSK61.33439916
45IRAK21.24661141
46DYRK1B1.21249049
47NME21.20926930
48MAP2K21.17362907
49PKN11.16746946
50CSK1.12312333
51BRD41.11648361
52TYRO31.06152838
53MAP3K11.05130455
54PHKG21.02562041
55PHKG11.02562041
56TESK11.02182880
57PRKCH1.01766647
58TGFBR11.01236141
59GRK60.99310143
60RIPK10.94928919
61PRKD30.92962352
62TAOK30.92482627
63MATK0.89806134
64HIPK20.89786917
65EPHA30.89455507
66PIK3CG0.88092878
67PAK60.87834251
68JAK20.87411477
69TNK20.86602536
70MAP3K30.86187504
71NEK90.84931948
72PRKD20.83259763
73PDPK10.83075080
74DAPK30.81659979
75SIK20.80621351
76MAP3K100.80544703
77MAP3K110.79644409
78ARAF0.77684348
79NTRK30.76215642
80PRKAA20.75540732
81DDR20.75213248
82MAP2K60.74065183
83CAMK40.73681516
84PDK10.73089603
85FES0.72546382
86PIM20.72048570
87MAPK120.71968301
88PKN20.71841129
89MAP3K60.70139070
90RPS6KA20.67779318
91MARK20.66768922
92RPS6KA60.66316848
93STK380.65787916
94HCK0.64691215
95MAPK70.64331347
96CLK10.64041193
97DYRK30.63871767
98TESK20.63854778
99KSR20.63307103
100FGFR30.63289151
101OBSCN0.62819329
102PASK0.61448253
103FGR0.61446439
104MAPKAPK30.60801407
105PIM10.59039837
106LYN0.58865799
107MAP2K30.57106891
108CASK0.57099381
109LCK0.56230062
110MAPK110.55415097
111BMX0.55076017
112EPHA40.54397555
113CAMK10.54047185
114GRK10.53721012
115RPS6KC10.53224670
116RPS6KL10.53224670
117PTK60.51950913
118LIMK10.51307247
119ITK0.50888983
120AKT20.50667068
121MUSK0.50306206
122MAPK40.48632982
123CDK190.46968841
124UHMK10.46303353
125EEF2K0.46177892
126FYN0.45025902
127CAMK1D0.44763170
128PRKD10.44291166
129RPS6KA40.44235386
130MAPKAPK20.44005203
131BUB10.41641469
132TIE10.41350069
133TTN0.41173777
134TXK0.40985095
135ICK0.40538854
136MYLK0.39692979

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.87901755
2B cell receptor signaling pathway_Homo sapiens_hsa046622.92650269
3Primary immunodeficiency_Homo sapiens_hsa053402.91651232
4Other glycan degradation_Homo sapiens_hsa005112.52615695
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.48338995
6Sulfur relay system_Homo sapiens_hsa041222.23087106
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.18623792
8Leishmaniasis_Homo sapiens_hsa051402.15157409
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98856923
10ABC transporters_Homo sapiens_hsa020101.90571859
11Acute myeloid leukemia_Homo sapiens_hsa052211.90507461
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.85460519
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.80208962
14Osteoclast differentiation_Homo sapiens_hsa043801.72307772
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.70406729
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68110240
17Fructose and mannose metabolism_Homo sapiens_hsa000511.67863526
18Ribosome_Homo sapiens_hsa030101.66816424
19Measles_Homo sapiens_hsa051621.55808124
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.53814262
21Tryptophan metabolism_Homo sapiens_hsa003801.49279677
22Graft-versus-host disease_Homo sapiens_hsa053321.46580800
23Autoimmune thyroid disease_Homo sapiens_hsa053201.43872565
24Staphylococcus aureus infection_Homo sapiens_hsa051501.42244620
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.38635042
26Adipocytokine signaling pathway_Homo sapiens_hsa049201.35384268
27Antigen processing and presentation_Homo sapiens_hsa046121.30655555
28Caffeine metabolism_Homo sapiens_hsa002321.29935806
29Malaria_Homo sapiens_hsa051441.29761226
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29636221
31VEGF signaling pathway_Homo sapiens_hsa043701.28058062
32Lysosome_Homo sapiens_hsa041421.25787139
33Peroxisome_Homo sapiens_hsa041461.23363647
34Fatty acid degradation_Homo sapiens_hsa000711.23223626
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21761328
36Phenylalanine metabolism_Homo sapiens_hsa003601.20626968
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19064936
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18981929
39GnRH signaling pathway_Homo sapiens_hsa049121.15544685
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.14565002
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13627598
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.12523807
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07990310
44Notch signaling pathway_Homo sapiens_hsa043301.07887419
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.05431585
46Apoptosis_Homo sapiens_hsa042101.04967686
47Viral myocarditis_Homo sapiens_hsa054161.04452826
48Type I diabetes mellitus_Homo sapiens_hsa049401.04134920
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.03010023
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02990460
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01329369
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.98466328
53Herpes simplex infection_Homo sapiens_hsa051680.98092034
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98053200
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97331094
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97282814
57Propanoate metabolism_Homo sapiens_hsa006400.97021657
58Prion diseases_Homo sapiens_hsa050200.94732048
59Biosynthesis of amino acids_Homo sapiens_hsa012300.92450182
60Toxoplasmosis_Homo sapiens_hsa051450.92019642
61Long-term potentiation_Homo sapiens_hsa047200.91489346
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.89676235
63Folate biosynthesis_Homo sapiens_hsa007900.88944044
64Insulin resistance_Homo sapiens_hsa049310.88926544
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88887062
66Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88632161
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.85986694
68Lysine degradation_Homo sapiens_hsa003100.85968022
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85477031
70Oxytocin signaling pathway_Homo sapiens_hsa049210.85302330
71beta-Alanine metabolism_Homo sapiens_hsa004100.84875294
72Selenocompound metabolism_Homo sapiens_hsa004500.84436146
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.83530270
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.81475942
75Epstein-Barr virus infection_Homo sapiens_hsa051690.81060363
76Pertussis_Homo sapiens_hsa051330.81035987
77Gastric acid secretion_Homo sapiens_hsa049710.80954662
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.79474411
79Endocytosis_Homo sapiens_hsa041440.78004325
80African trypanosomiasis_Homo sapiens_hsa051430.77154084
81MAPK signaling pathway_Homo sapiens_hsa040100.76602122
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76506859
83Asthma_Homo sapiens_hsa053100.75813875
84Chemokine signaling pathway_Homo sapiens_hsa040620.75487632
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.75252824
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75206670
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75105088
88Prolactin signaling pathway_Homo sapiens_hsa049170.74423984
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73596345
90Choline metabolism in cancer_Homo sapiens_hsa052310.71107704
91Galactose metabolism_Homo sapiens_hsa000520.70863348
92Pentose phosphate pathway_Homo sapiens_hsa000300.70852631
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.70472350
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.69912191
95Tuberculosis_Homo sapiens_hsa051520.69790451
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69729238
97Influenza A_Homo sapiens_hsa051640.67835513
98Insulin secretion_Homo sapiens_hsa049110.67310485
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67229111
100Cholinergic synapse_Homo sapiens_hsa047250.67148241
101Non-small cell lung cancer_Homo sapiens_hsa052230.66975308
102Rheumatoid arthritis_Homo sapiens_hsa053230.66908298
103Hematopoietic cell lineage_Homo sapiens_hsa046400.66825775
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66509617
105Morphine addiction_Homo sapiens_hsa050320.65787537
106Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65374571
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65329927
108Chronic myeloid leukemia_Homo sapiens_hsa052200.65072022
109Amoebiasis_Homo sapiens_hsa051460.64796864
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64472918
111Phagosome_Homo sapiens_hsa041450.64000959
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63706454
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62819038
114TNF signaling pathway_Homo sapiens_hsa046680.62397000
115Fatty acid elongation_Homo sapiens_hsa000620.61761085
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61575855
117Dilated cardiomyopathy_Homo sapiens_hsa054140.60919402
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60900110
119Regulation of autophagy_Homo sapiens_hsa041400.60288941
120Circadian entrainment_Homo sapiens_hsa047130.60262207
121PPAR signaling pathway_Homo sapiens_hsa033200.60194227
122Estrogen signaling pathway_Homo sapiens_hsa049150.59966551
123Base excision repair_Homo sapiens_hsa034100.59754233
124Bladder cancer_Homo sapiens_hsa052190.59243181
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58821903
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58181185
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58171368
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.57163735
129Platelet activation_Homo sapiens_hsa046110.56662173
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56130340
131mTOR signaling pathway_Homo sapiens_hsa041500.56024220
132Salivary secretion_Homo sapiens_hsa049700.55762243
133AMPK signaling pathway_Homo sapiens_hsa041520.55675185
134Calcium signaling pathway_Homo sapiens_hsa040200.55192890
135Salmonella infection_Homo sapiens_hsa051320.54833733
136Complement and coagulation cascades_Homo sapiens_hsa046100.53183032
137Fatty acid metabolism_Homo sapiens_hsa012120.52938729
138Carbon metabolism_Homo sapiens_hsa012000.52006400
139Insulin signaling pathway_Homo sapiens_hsa049100.51302516
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50978015
141Legionellosis_Homo sapiens_hsa051340.50628497
142Shigellosis_Homo sapiens_hsa051310.49525412
143Collecting duct acid secretion_Homo sapiens_hsa049660.48772815
144Maturity onset diabetes of the young_Homo sapiens_hsa049500.48687810
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48175612
146Hepatitis C_Homo sapiens_hsa051600.47510671
147Allograft rejection_Homo sapiens_hsa053300.47216412
148T cell receptor signaling pathway_Homo sapiens_hsa046600.47142037
149Butanoate metabolism_Homo sapiens_hsa006500.44372098
150Pyrimidine metabolism_Homo sapiens_hsa002400.43719627
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41979002
152Type II diabetes mellitus_Homo sapiens_hsa049300.41357483
153Synaptic vesicle cycle_Homo sapiens_hsa047210.41019813

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