TBC1D21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.88313209
2axonemal dynein complex assembly (GO:0070286)9.73081711
3spermatid development (GO:0007286)9.68349761
4motile cilium assembly (GO:0044458)9.57646151
5reproduction (GO:0000003)9.42185778
6regulation of cilium movement (GO:0003352)9.12585248
7cilium or flagellum-dependent cell motility (GO:0001539)8.90443783
8cilium movement (GO:0003341)7.97142453
9single fertilization (GO:0007338)7.40222301
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.39328748
11sperm capacitation (GO:0048240)7.11867586
12negative regulation of inclusion body assembly (GO:0090084)6.98737777
13synaptonemal complex organization (GO:0070193)6.90535770
14piRNA metabolic process (GO:0034587)6.81904542
15synaptonemal complex assembly (GO:0007130)6.77901243
16male meiosis (GO:0007140)6.74120634
17organic cation transport (GO:0015695)6.72760427
18spermatogenesis (GO:0007283)6.64093849
19male gamete generation (GO:0048232)6.61691540
20microtubule depolymerization (GO:0007019)6.54965874
21fertilization (GO:0009566)6.24553025
22gamete generation (GO:0007276)6.08002444
23regulation of inclusion body assembly (GO:0090083)5.86065902
24ventricular system development (GO:0021591)5.54328222
25calcium ion-dependent exocytosis (GO:0017156)5.46871479
26germ cell development (GO:0007281)5.39223094
27regulation of microtubule-based movement (GO:0060632)5.38135649
28cellular process involved in reproduction in multicellular organism (GO:0022412)5.31180780
29chromosome condensation (GO:0030261)5.31109307
30spermatid nucleus differentiation (GO:0007289)5.19513380
31microtubule severing (GO:0051013)5.05609268
32DNA packaging (GO:0006323)4.99517003
33cell recognition (GO:0008037)4.93872477
34glycerol ether metabolic process (GO:0006662)4.89981685
35multicellular organismal reproductive process (GO:0048609)4.79754330
36seminiferous tubule development (GO:0072520)4.64002183
37chromosome organization involved in meiosis (GO:0070192)4.60935422
38male meiosis I (GO:0007141)4.54332027
39ether metabolic process (GO:0018904)4.52418309
40sexual reproduction (GO:0019953)4.41592931
41DNA methylation involved in gamete generation (GO:0043046)4.33940698
42single strand break repair (GO:0000012)4.32522707
43left/right pattern formation (GO:0060972)4.23532565
44meiotic nuclear division (GO:0007126)4.09164421
45chaperone-mediated protein complex assembly (GO:0051131)3.99438799
46multicellular organismal development (GO:0007275)3.90250999
47protein polyglutamylation (GO:0018095)3.79238020
48genitalia morphogenesis (GO:0035112)3.70448622
49protein K11-linked deubiquitination (GO:0035871)3.63947085
50meiosis I (GO:0007127)3.60488311
51sequestering of actin monomers (GO:0042989)3.45216444
52meiotic cell cycle (GO:0051321)3.35487710
53microtubule polymerization or depolymerization (GO:0031109)3.34272578
54protein localization to cilium (GO:0061512)3.30344314
55glycolytic process (GO:0006096)3.29479078
56monoubiquitinated protein deubiquitination (GO:0035520)3.23814384
57nucleus organization (GO:0006997)3.21833058
58regulation of spindle checkpoint (GO:0090231)3.20462472
59protein refolding (GO:0042026)3.12247105
60interferon-gamma secretion (GO:0072643)3.09055923
61regulation of response to osmotic stress (GO:0047484)3.05809979
62nucleoside diphosphate phosphorylation (GO:0006165)3.05718492
63carnitine transport (GO:0015879)3.01134089
64amino-acid betaine transport (GO:0015838)3.01134089
65RNA localization (GO:0006403)2.98704764
66mitotic sister chromatid cohesion (GO:0007064)2.98064659
67polyol catabolic process (GO:0046174)2.96478660
68alditol metabolic process (GO:0019400)2.87739096
69carnitine transmembrane transport (GO:1902603)2.83942128
70positive regulation of macrophage activation (GO:0043032)2.79592592
71cilium organization (GO:0044782)2.78931537
72chromatin silencing (GO:0006342)2.72762967
73cilium assembly (GO:0042384)2.69200668
74meiotic cell cycle process (GO:1903046)2.68368749
75microtubule-based movement (GO:0007018)2.68079297
76cellular component assembly involved in morphogenesis (GO:0010927)2.66392245
77synapsis (GO:0007129)2.64241968
78GTP biosynthetic process (GO:0006183)2.61790503
79polyamine biosynthetic process (GO:0006596)2.61159557
80cilium morphogenesis (GO:0060271)2.60147052
81RNA destabilization (GO:0050779)2.59287026
82protein localization to chromosome, centromeric region (GO:0071459)2.58491859
83peptidyl-glutamic acid modification (GO:0018200)2.53993885
84gene silencing by RNA (GO:0031047)2.50875670
85axoneme assembly (GO:0035082)2.48906456
86intraciliary transport (GO:0042073)2.48310413
87nuclear pore complex assembly (GO:0051292)2.47012656
88nucleosome disassembly (GO:0006337)2.45486315
89protein-DNA complex disassembly (GO:0032986)2.45486315
90sperm motility (GO:0030317)13.9011707
91fusion of sperm to egg plasma membrane (GO:0007342)13.5566052
92cell wall macromolecule metabolic process (GO:0044036)13.4118987
93cell wall macromolecule catabolic process (GO:0016998)13.4118987
94acrosome reaction (GO:0007340)12.0044208
95sperm-egg recognition (GO:0035036)11.4319724
96acrosome assembly (GO:0001675)11.4143909
97multicellular organism reproduction (GO:0032504)10.8521230
98binding of sperm to zona pellucida (GO:0007339)10.4150472
99plasma membrane fusion (GO:0045026)10.3097878
100cell-cell recognition (GO:0009988)10.2280085

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.91048033
2EZH2_22144423_ChIP-Seq_EOC_Human3.90615653
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.66117573
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.24423462
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.00281544
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.83598916
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.81373255
8VDR_22108803_ChIP-Seq_LS180_Human2.51842121
9CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.26170438
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.25850653
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.06491969
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.97616527
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95240551
14ELK4_26923725_Chip-Seq_MESODERM_Mouse1.88548396
15KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.85855015
16ZNF274_21170338_ChIP-Seq_K562_Hela1.73763871
17* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71384124
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66894411
19TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.66165654
20STAT1_17558387_ChIP-Seq_HELA_Human1.64121752
21* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63087858
22SOX2_22085726_ChIP-Seq_NPCs_Mouse1.61547870
23GATA3_21867929_ChIP-Seq_CD8_Mouse1.60293267
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59583030
25GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.54278543
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.53919387
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45393084
28KAP1_22055183_ChIP-Seq_ESCs_Mouse1.45026161
29PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44903843
30TAL1_26923725_Chip-Seq_HPCs_Mouse1.42576885
31RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41854530
32* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39483104
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.37890868
34KDM2B_26808549_Chip-Seq_REH_Human1.37123774
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36770309
36CBP_20019798_ChIP-Seq_JUKART_Human1.36770309
37PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35308401
38LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33753556
39SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33736443
40P53_21459846_ChIP-Seq_SAOS-2_Human1.31967835
41CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27001410
42GATA3_21867929_ChIP-Seq_TH1_Mouse1.26973377
43SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25033836
44* REST_21632747_ChIP-Seq_MESCs_Mouse1.24674908
45SPI1_26923725_Chip-Seq_HPCs_Mouse1.24602351
46SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.23407339
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23245667
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22938564
49CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20843791
50GF1_26923725_Chip-Seq_HPCs_Mouse1.20606702
51RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20501964
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13918930
53* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13747732
54RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13605353
55YY1_22570637_ChIP-Seq_MALME-3M_Human1.13275654
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.13260246
57RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13222162
58FLI1_21867929_ChIP-Seq_TH2_Mouse1.13181210
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12200406
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12200406
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11541988
62MYC_27129775_Chip-Seq_CORNEA_Mouse1.10550914
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09914541
64ERG_20517297_ChIP-Seq_VCAP_Human1.08984812
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08825553
66* ESET_19884257_ChIP-Seq_ESCs_Mouse1.08318407
67EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.07269593
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.07070628
69RARA_24833708_ChIP-Seq_LIVER_Mouse1.05837054
70GATA1_19941827_ChIP-Seq_MEL86_Mouse1.05588548
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03053047
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02899473
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.02631789
74EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02619311
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02323132
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01247688
77PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00994160
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.00297072
79CTCF_20526341_ChIP-Seq_ESCs_Human1.00005948
80STAT3_18555785_ChIP-Seq_MESCs_Mouse0.98637141
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97247333
82LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97002906
83RNF2_27304074_Chip-Seq_NSC_Mouse0.96837150
84* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.96288340
85CRX_20693478_ChIP-Seq_RETINA_Mouse0.93847423
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93714184
87BCOR_27268052_Chip-Seq_Bcells_Human0.93415109
88OCT4_18555785_Chip-Seq_ESCs_Mouse0.92135301
89NANOG_18555785_Chip-Seq_ESCs_Mouse0.91704793
90NANOG_20526341_ChIP-Seq_ESCs_Human0.91655551
91SOX11_22085726_ChIP-Seq_ESNs_Mouse0.91458562
92KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89367239
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87678454
94NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87643083
95PHF8_20622854_ChIP-Seq_HELA_Human0.87252189
96* FLI1_21867929_ChIP-Seq_CD8_Mouse0.86701860
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84286904
98SOX2_21211035_ChIP-Seq_LN229_Human0.83975385
99KLF4_18555785_Chip-Seq_ESCs_Mouse0.83888586
100CMYC_18555785_Chip-Seq_ESCs_Mouse0.83773906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.02331888
2MP0001929_abnormal_gametogenesis5.47797313
3MP0008877_abnormal_DNA_methylation3.74687237
4MP0002210_abnormal_sex_determination3.30659035
5MP0002161_abnormal_fertility/fecundity3.27473416
6MP0005670_abnormal_white_adipose2.96972482
7MP0001145_abnormal_male_reproductive2.84769674
8MP0002653_abnormal_ependyma_morphology2.60890219
9MP0000653_abnormal_sex_gland2.41764575
10MP0005410_abnormal_fertilization16.4933517
11MP0005623_abnormal_meninges_morphology1.45340824
12MP0002160_abnormal_reproductive_system1.45294470
13MP0003011_delayed_dark_adaptation1.40981077
14MP0004233_abnormal_muscle_weight1.30845908
15MP0003646_muscle_fatigue1.23965336
16MP0002282_abnormal_trachea_morphology1.16979191
17MP0001765_abnormal_ion_homeostasis1.07606112
18MP0002234_abnormal_pharynx_morphology0.95362489
19MP0001984_abnormal_olfaction0.89837881
20MP0005647_abnormal_sex_gland0.82232672
21MP0008058_abnormal_DNA_repair0.79396484
22MP0009046_muscle_twitch0.74855235
23MP0003115_abnormal_respiratory_system0.70569187
24MP0005389_reproductive_system_phenotype0.68986603
25MP0001293_anophthalmia0.65128252
26MP0005377_hearing/vestibular/ear_phenot0.61663253
27MP0003878_abnormal_ear_physiology0.61663253
28MP0002269_muscular_atrophy0.60354054
29MP0001324_abnormal_eye_pigmentation0.59278642
30MP0008995_early_reproductive_senescence0.56977124
31MP0005666_abnormal_adipose_tissue0.56842066
32MP0006035_abnormal_mitochondrial_morpho0.56580468
33MP0000358_abnormal_cell_content/0.55238333
34MP0005636_abnormal_mineral_homeostasis0.54818627
35MP0010094_abnormal_chromosome_stability0.49171062
36MP0008057_abnormal_DNA_replication0.48160866
37MP0006036_abnormal_mitochondrial_physio0.47093418
38MP0009115_abnormal_fat_cell0.45713730
39MP0004133_heterotaxia0.44190518
40MP0005253_abnormal_eye_physiology0.44178424
41MP0001849_ear_inflammation0.43508251
42MP0008961_abnormal_basal_metabolism0.43498411
43MP0004264_abnormal_extraembryonic_tissu0.43426514
44MP0005391_vision/eye_phenotype0.42474744
45MP0003699_abnormal_female_reproductive0.40489882
46MP0000534_abnormal_ureter_morphology0.40154424
47MP0004036_abnormal_muscle_relaxation0.39125322
48MP0002928_abnormal_bile_duct0.38978675
49MP0002132_abnormal_respiratory_system0.38934138
50MP0002092_abnormal_eye_morphology0.37422486
51MP0001348_abnormal_lacrimal_gland0.36470365
52MP0003111_abnormal_nucleus_morphology0.36111722
53MP0003329_amyloid_beta_deposits0.34799548
54MP0004043_abnormal_pH_regulation0.34743613
55MP0005551_abnormal_eye_electrophysiolog0.34045042
56MP0003942_abnormal_urinary_system0.33574093
57MP0003950_abnormal_plasma_membrane0.33066845
58MP0005075_abnormal_melanosome_morpholog0.33002050
59MP0005380_embryogenesis_phenotype0.32232180
60MP0001672_abnormal_embryogenesis/_devel0.32232180
61MP0001764_abnormal_homeostasis0.31688512
62MP0005397_hematopoietic_system_phenotyp0.30808325
63MP0001545_abnormal_hematopoietic_system0.30808325
64MP0003890_abnormal_embryonic-extraembry0.29753016
65MP0005257_abnormal_intraocular_pressure0.29183355
66MP0001730_embryonic_growth_arrest0.28883720
67MP0003861_abnormal_nervous_system0.28205777
68MP0003984_embryonic_growth_retardation0.26673439
69MP0009278_abnormal_bone_marrow0.26196391
70MP0002971_abnormal_brown_adipose0.25467613
71MP0002088_abnormal_embryonic_growth/wei0.25383725
72MP0005499_abnormal_olfactory_system0.25225352
73MP0005394_taste/olfaction_phenotype0.25225352
74MP0002970_abnormal_white_adipose0.25187919
75MP0006082_CNS_inflammation0.24949182
76MP0002084_abnormal_developmental_patter0.24666761
77MP0003786_premature_aging0.24563031
78MP0000313_abnormal_cell_death0.23701271
79MP0001119_abnormal_female_reproductive0.23327395
80MP0002736_abnormal_nociception_after0.22195902
81MP0003183_abnormal_peptide_metabolism0.22144157
82MP0002932_abnormal_joint_morphology0.20711766
83MP0004019_abnormal_vitamin_homeostasis0.20616324
84MP0005319_abnormal_enzyme/_coenzyme0.20433545
85MP0002169_no_abnormal_phenotype0.20419049
86MP0002102_abnormal_ear_morphology0.20298167
87MP0004811_abnormal_neuron_physiology0.20124384
88MP0002873_normal_phenotype0.20110967
89MP0000678_abnormal_parathyroid_gland0.20049462
90MP0003787_abnormal_imprinting0.19986788
91MP0003948_abnormal_gas_homeostasis0.19662888
92MP0001661_extended_life_span0.19074391
93MP0001270_distended_abdomen0.19053776
94MP0000432_abnormal_head_morphology0.18937940
95MP0000569_abnormal_digit_pigmentation0.18908400
96MP0008770_decreased_survivor_rate0.18825915
97MP0003633_abnormal_nervous_system0.18482731
98MP0002254_reproductive_system_inflammat0.17972673
99MP0002108_abnormal_muscle_morphology0.17646787
100MP0002152_abnormal_brain_morphology0.17419271

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.19887449
2Abnormal respiratory epithelium morphology (HP:0012253)9.19688934
3Abnormal respiratory motile cilium morphology (HP:0005938)9.19688934
4Chronic bronchitis (HP:0004469)7.42466029
5Rhinitis (HP:0012384)7.40054468
6Abnormal ciliary motility (HP:0012262)7.25931168
7Infertility (HP:0000789)6.78040610
8Nasal polyposis (HP:0100582)6.74869903
9Abnormality of the nasal mucosa (HP:0000433)5.56125008
10Male infertility (HP:0003251)4.62691754
11Bronchitis (HP:0012387)4.57754091
12Bronchiectasis (HP:0002110)4.32599517
13Nephronophthisis (HP:0000090)3.88825417
14Abnormal spermatogenesis (HP:0008669)3.37202754
15Recurrent sinusitis (HP:0011108)3.24560245
16Recurrent otitis media (HP:0000403)3.19743426
17Impulsivity (HP:0100710)2.96272843
18Abnormality of the renal medulla (HP:0100957)2.89949141
19Recurrent bronchitis (HP:0002837)2.67946132
20Molar tooth sign on MRI (HP:0002419)2.60250588
21Abnormality of midbrain morphology (HP:0002418)2.60250588
22Tubulointerstitial nephritis (HP:0001970)2.58747904
23Dyschromatopsia (HP:0007641)2.40053756
24Medial flaring of the eyebrow (HP:0010747)2.35427544
25Tubular atrophy (HP:0000092)2.35169813
26Abnormal gallbladder physiology (HP:0012438)2.28944838
27Cholecystitis (HP:0001082)2.28944838
28Gonadotropin excess (HP:0000837)2.24650865
29Spastic tetraparesis (HP:0001285)2.15101205
30Tubulointerstitial abnormality (HP:0001969)2.13810557
31Azoospermia (HP:0000027)2.04631808
32Abnormality of the lower motor neuron (HP:0002366)2.01252438
33Dynein arm defect of respiratory motile cilia (HP:0012255)13.3824000
34Absent/shortened dynein arms (HP:0200106)13.3824000
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0281206
36Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87201427
37Abnormal biliary tract physiology (HP:0012439)1.83481775
38Bile duct proliferation (HP:0001408)1.83481775
39Heterotopia (HP:0002282)1.82444164
40Choroideremia (HP:0001139)1.81795072
41Postaxial foot polydactyly (HP:0001830)1.76227756
42Decreased central vision (HP:0007663)1.71646481
43Tubulointerstitial fibrosis (HP:0005576)1.65632909
44Congenital hepatic fibrosis (HP:0002612)1.61193470
45Stage 5 chronic kidney disease (HP:0003774)1.60039540
46Hemorrhage of the eye (HP:0011885)1.59273428
47Sensory axonal neuropathy (HP:0003390)1.58967272
48Facial cleft (HP:0002006)1.58208677
49Abnormality of permanent molar morphology (HP:0011071)1.57265716
50Abnormality of the dental root (HP:0006486)1.57265716
51Taurodontia (HP:0000679)1.57265716
52Bell-shaped thorax (HP:0001591)1.54776529
53Amyotrophic lateral sclerosis (HP:0007354)1.51380741
54Abnormal drinking behavior (HP:0030082)1.50566058
55Polydipsia (HP:0001959)1.50566058
56Oculomotor apraxia (HP:0000657)1.49482278
57Aplasia/Hypoplasia of the lens (HP:0008063)1.48337546
58Short ribs (HP:0000773)1.47551567
59Postaxial hand polydactyly (HP:0001162)1.46215133
60Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.45440958
61Absent epiphyses (HP:0010577)1.45440958
62Abnormality of renal excretion (HP:0011036)1.45041331
63Hemiparesis (HP:0001269)1.44409165
64Abnormality of the dental pulp (HP:0006479)1.44360690
65Abnormality of molar (HP:0011077)1.44232510
66Abnormality of molar morphology (HP:0011070)1.44232510
67Abnormality of dentin (HP:0010299)1.39279175
68Abnormality of the renal cortex (HP:0011035)1.39147560
69Asymmetric septal hypertrophy (HP:0001670)1.38964039
70Deformed sella turcica (HP:0002681)1.37095981
71Congenital malformation of the right heart (HP:0011723)1.37095636
72Double outlet right ventricle (HP:0001719)1.37095636
73Neurofibrillary tangles (HP:0002185)1.36476322
74Congenital primary aphakia (HP:0007707)1.34515613
75Gait imbalance (HP:0002141)1.34181268
76Neoplasm of the heart (HP:0100544)1.31724766
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.31292986
78Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.30996051
79Supernumerary spleens (HP:0009799)1.30094558
80Renal dysplasia (HP:0000110)1.29958134
81Easy fatigability (HP:0003388)1.29876328
82Fibular hypoplasia (HP:0003038)1.29074235
83Bundle branch block (HP:0011710)1.26915921
84Pendular nystagmus (HP:0012043)1.26909300
85Absent frontal sinuses (HP:0002688)1.26625637
86Chronic sinusitis (HP:0011109)1.24798059
87Cystic liver disease (HP:0006706)1.24339055
88J-shaped sella turcica (HP:0002680)1.23117755
89Impaired proprioception (HP:0010831)1.22264978
90Short thorax (HP:0010306)1.19480264
91Abnormality of the neuromuscular junction (HP:0003398)1.17416141
92Fatigable weakness (HP:0003473)1.17416141
93Constricted visual fields (HP:0001133)1.17022693
94Hypercholesterolemia (HP:0003124)1.16674960
95Abnormal urine output (HP:0012590)1.15460308
96Truncal obesity (HP:0001956)1.13973655
97Short humerus (HP:0005792)1.12277767
98Myoglobinuria (HP:0002913)1.12031143
99EMG: neuropathic changes (HP:0003445)1.11969772
100Exercise-induced myalgia (HP:0003738)1.11320110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.24968923
2PDK48.24968923
3TESK15.99860185
4PDK25.33369663
5PRKD34.95826428
6ICK4.35382358
7PTK2B1.99360493
8WNK41.88364600
9STK391.78705571
10STK381.76115574
11PNCK1.60229426
12DYRK1B1.60197285
13NEK21.55874533
14CDK121.33058685
15TYRO31.19074072
16PDK11.15455500
17WNK11.00506331
18DYRK30.89037584
19TTK0.86121717
20GRK50.81729592
21MAPK150.77315892
22IRAK10.76027688
23MAP2K60.72796794
24CHEK20.68700161
25PDPK10.64257190
26TESK20.62912769
27PASK0.59822083
28STK30.59068315
29RIPK40.58209974
30GRK60.56241055
31MAP3K100.54894608
32CCNB10.54172369
33GRK10.49521722
34MARK20.49078129
35LMTK20.48129814
36EEF2K0.46740430
37PINK10.46137472
38CHEK10.44180383
39CAMK1G0.43862444
40ERN10.43815408
41CSF1R0.42802932
42ADRBK20.42090814
43PAK10.41590122
44IRAK20.40416836
45PAK40.40011697
46NTRK20.38530643
47STK38L0.34370933
48PRKCG0.33937387
49PRKG20.32001600
50STK100.31954054
51MTOR0.31694281
52MUSK0.30297539
53ATM0.27756200
54PAK20.27003098
55PLK10.22883203
56PLK40.20599016
57PRKAA10.20007102
58ATR0.18540684
59CDC70.17244019
60TGFBR20.16641089
61WEE10.15611172
62MAPKAPK50.14016511
63CDK150.13855643
64CAMKK10.13374086
65PRKCZ0.12360356
66MAPK70.11742822
67GRK70.11669394
68NEK60.11514362
69CDK180.10857177
70CDK11A0.09836143
71PRKCQ0.09789032
72MATK0.08403553
73GSK3B0.07993903
74BRSK20.07580278
75RPS6KB10.06778373
76PRKCD0.06740875
77CDK20.06413438
78PRKACG0.05569421
79CDK140.05245234
80CSK0.04932597
81NTRK10.04505912
82RIPK10.04484163
83RPS6KA10.04308995
84CSNK2A10.03639680
85CDK10.03404611
86PKN10.03359137
87MAPK80.01843316
88YES10.01167571
89MARK30.01078104
90PRKG10.00951244
91CSNK1D0.00911334
92BRSK10.00690071
93AURKA0.00355849
94PRKACB0.00090673
95CDK40.00022699
96GSK3A-0.0149697
97PIM1-0.0126739
98IGF1R-0.0090248
99RPS6KA3-0.0081264
100EGFR-0.0029504

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.53451403
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.47276560
3Fatty acid biosynthesis_Homo sapiens_hsa000614.39056925
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.41038657
5Linoleic acid metabolism_Homo sapiens_hsa005913.33284766
6Pyruvate metabolism_Homo sapiens_hsa006203.22321546
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.52662196
8Glucagon signaling pathway_Homo sapiens_hsa049222.40841706
9Propanoate metabolism_Homo sapiens_hsa006402.38290834
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.19022584
11Basal transcription factors_Homo sapiens_hsa030222.18218382
12Fructose and mannose metabolism_Homo sapiens_hsa000512.15494363
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.14378035
14Glycerolipid metabolism_Homo sapiens_hsa005612.00425297
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98261577
16Selenocompound metabolism_Homo sapiens_hsa004501.93257012
17PPAR signaling pathway_Homo sapiens_hsa033201.86710913
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.83419075
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.73718329
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.69478637
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62171104
22Pentose phosphate pathway_Homo sapiens_hsa000301.59600644
23Ether lipid metabolism_Homo sapiens_hsa005651.55878054
24Oocyte meiosis_Homo sapiens_hsa041141.55164321
25Dorso-ventral axis formation_Homo sapiens_hsa043201.48265034
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.45850313
27Mineral absorption_Homo sapiens_hsa049781.39399240
28Fat digestion and absorption_Homo sapiens_hsa049751.34272459
29Carbon metabolism_Homo sapiens_hsa012001.33616125
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32390273
31Fanconi anemia pathway_Homo sapiens_hsa034601.31901041
32Amphetamine addiction_Homo sapiens_hsa050311.27259726
33Arachidonic acid metabolism_Homo sapiens_hsa005901.24665729
34Fatty acid metabolism_Homo sapiens_hsa012121.23013629
35Fatty acid degradation_Homo sapiens_hsa000711.22392644
36Cardiac muscle contraction_Homo sapiens_hsa042601.21325729
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.10451330
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05320317
39mRNA surveillance pathway_Homo sapiens_hsa030151.02871384
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.01250718
41Antigen processing and presentation_Homo sapiens_hsa046120.99684979
42Renin secretion_Homo sapiens_hsa049240.99567816
43Hedgehog signaling pathway_Homo sapiens_hsa043400.96058035
44Chemical carcinogenesis_Homo sapiens_hsa052040.94565953
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92173337
46Purine metabolism_Homo sapiens_hsa002300.90109002
47RNA transport_Homo sapiens_hsa030130.89867700
48Glutathione metabolism_Homo sapiens_hsa004800.89560075
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.79708446
50Biosynthesis of amino acids_Homo sapiens_hsa012300.79375567
51Huntingtons disease_Homo sapiens_hsa050160.77960890
52Collecting duct acid secretion_Homo sapiens_hsa049660.75128384
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.73194597
54Bile secretion_Homo sapiens_hsa049760.70550369
55Insulin secretion_Homo sapiens_hsa049110.65557539
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65163473
57Long-term potentiation_Homo sapiens_hsa047200.64619547
58Inositol phosphate metabolism_Homo sapiens_hsa005620.63061823
59Estrogen signaling pathway_Homo sapiens_hsa049150.62415061
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61714071
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61480567
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60944211
63Thyroid hormone synthesis_Homo sapiens_hsa049180.58748086
64Protein digestion and absorption_Homo sapiens_hsa049740.56798517
65Calcium signaling pathway_Homo sapiens_hsa040200.54932976
66Legionellosis_Homo sapiens_hsa051340.54378495
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54097110
68ABC transporters_Homo sapiens_hsa020100.52742945
69Renin-angiotensin system_Homo sapiens_hsa046140.52594750
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50763067
71AMPK signaling pathway_Homo sapiens_hsa041520.46697434
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.46284319
73Systemic lupus erythematosus_Homo sapiens_hsa053220.46211294
74Salivary secretion_Homo sapiens_hsa049700.43428817
75Taste transduction_Homo sapiens_hsa047420.43397644
76VEGF signaling pathway_Homo sapiens_hsa043700.42913822
77Endocytosis_Homo sapiens_hsa041440.40297045
78Pancreatic secretion_Homo sapiens_hsa049720.39186313
79Metabolic pathways_Homo sapiens_hsa011000.37704165
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35345940
81cAMP signaling pathway_Homo sapiens_hsa040240.32542060
82Synaptic vesicle cycle_Homo sapiens_hsa047210.29838841
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29748125
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29694170
85Gastric acid secretion_Homo sapiens_hsa049710.26545731
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21310624
87Alcoholism_Homo sapiens_hsa050340.19755805
88Basal cell carcinoma_Homo sapiens_hsa052170.19659436
89Galactose metabolism_Homo sapiens_hsa000520.18954317
90Pyrimidine metabolism_Homo sapiens_hsa002400.17878487
91Wnt signaling pathway_Homo sapiens_hsa043100.15490308
92Circadian entrainment_Homo sapiens_hsa047130.13889499
93Sulfur metabolism_Homo sapiens_hsa009200.12816975
94B cell receptor signaling pathway_Homo sapiens_hsa046620.08623774
95HIF-1 signaling pathway_Homo sapiens_hsa040660.08566050
96Glutamatergic synapse_Homo sapiens_hsa047240.05861364
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.05079907
98Cocaine addiction_Homo sapiens_hsa050300.03495547
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.03290534
100Insulin resistance_Homo sapiens_hsa049310.03022259

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