TBC1D22A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.51888668
2positive regulation of gamma-delta T cell activation (GO:0046645)4.49480057
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.46493401
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.46493401
5regulation of interferon-beta biosynthetic process (GO:0045357)4.45948635
6positive regulation by symbiont of host defense response (GO:0052509)4.43702536
7modulation by symbiont of host defense response (GO:0052031)4.43702536
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.43702536
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.43702536
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.43702536
11modulation by symbiont of host immune response (GO:0052553)4.43702536
12antigen processing and presentation of endogenous antigen (GO:0019883)4.02855214
13detection of other organism (GO:0098543)3.88277897
14regulation of gamma-delta T cell differentiation (GO:0045586)3.87124665
15detection of bacterium (GO:0016045)3.84947571
16pyrimidine ribonucleoside catabolic process (GO:0046133)3.81361578
17macrophage activation involved in immune response (GO:0002281)3.70271614
18regulation of gamma-delta T cell activation (GO:0046643)3.66749211
19regulation of cholesterol storage (GO:0010885)3.64796224
20defense response to protozoan (GO:0042832)3.62429247
21low-density lipoprotein particle clearance (GO:0034383)3.57191659
22response to protozoan (GO:0001562)3.55765911
23response to muramyl dipeptide (GO:0032495)3.46584022
24detection of external biotic stimulus (GO:0098581)3.45122218
25mannose metabolic process (GO:0006013)3.43528998
26positive regulation of p38MAPK cascade (GO:1900745)3.43159779
27type I interferon signaling pathway (GO:0060337)3.41833520
28cellular response to type I interferon (GO:0071357)3.41833520
29cellular extravasation (GO:0045123)3.37328368
30detection of molecule of bacterial origin (GO:0032490)3.35807834
31positive regulation of interferon-alpha production (GO:0032727)3.34231748
32positive regulation of B cell differentiation (GO:0045579)3.28165999
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.26080764
34negative thymic T cell selection (GO:0045060)3.25585876
35apoptotic cell clearance (GO:0043277)3.21178222
36negative regulation of innate immune response (GO:0045824)3.21040180
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.18466098
38negative regulation of T cell mediated immunity (GO:0002710)3.16857025
39regulation of mast cell degranulation (GO:0043304)3.16539411
40regulation of interferon-alpha production (GO:0032647)3.14967265
41negative T cell selection (GO:0043383)3.14820218
42regulation of T cell mediated cytotoxicity (GO:0001914)3.14607807
43regulation of B cell receptor signaling pathway (GO:0050855)3.10425774
44negative regulation of leukocyte mediated immunity (GO:0002704)3.10020398
45positive regulation of T cell mediated cytotoxicity (GO:0001916)3.09356654
46pinocytosis (GO:0006907)3.08476591
47tolerance induction (GO:0002507)3.07771112
48regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.06999847
49antigen processing and presentation via MHC class Ib (GO:0002475)3.05467771
50T-helper 1 type immune response (GO:0042088)3.03780288
51leukocyte aggregation (GO:0070486)3.00798056
52B cell mediated immunity (GO:0019724)3.00784187
53JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.00593322
54detection of biotic stimulus (GO:0009595)2.98925718
55positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.98076925
56positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.94516191
57neutrophil activation (GO:0042119)2.92575226
58neutrophil activation involved in immune response (GO:0002283)2.91032013
59germinal center formation (GO:0002467)2.90740077
60regulation of myeloid leukocyte mediated immunity (GO:0002886)2.90305611
61positive regulation of antigen processing and presentation (GO:0002579)2.89988959
62NIK/NF-kappaB signaling (GO:0038061)2.88392707
63T cell selection (GO:0045058)2.86752263
64regulation of mast cell activation (GO:0033003)2.86701925
65regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.85956041
66regulation of natural killer cell mediated immunity (GO:0002715)2.85956041
67regulation of mast cell activation involved in immune response (GO:0033006)2.85848206
68granulocyte activation (GO:0036230)2.85372127
69negative regulation of interleukin-6 production (GO:0032715)2.84879569
70positive regulation of mast cell activation (GO:0033005)2.84147205
71thymic T cell selection (GO:0045061)2.83342853
72positive T cell selection (GO:0043368)2.83246271
73interferon-gamma secretion (GO:0072643)2.80761309
74B cell homeostasis (GO:0001782)2.79542134
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.75918447
76positive regulation of histone deacetylation (GO:0031065)2.75417398
77regulation of T cell tolerance induction (GO:0002664)2.73306025
78regulation of leukocyte degranulation (GO:0043300)2.73122114
79myeloid cell activation involved in immune response (GO:0002275)2.72938817
80response to interleukin-15 (GO:0070672)2.72276660
81negative regulation of phagocytosis (GO:0050765)2.71479884
82immunoglobulin mediated immune response (GO:0016064)2.70421330
83lipoprotein transport (GO:0042953)2.68115945
84valine metabolic process (GO:0006573)2.67806789
85cellular response to interleukin-15 (GO:0071350)2.67325073
86negative regulation of erythrocyte differentiation (GO:0045647)2.65483208
87myeloid dendritic cell differentiation (GO:0043011)2.64576009
88L-alpha-amino acid transmembrane transport (GO:1902475)2.63670475
89regulation of tolerance induction (GO:0002643)2.61995172
90regulation of alpha-beta T cell proliferation (GO:0046640)2.60844895
91regulation of granulocyte differentiation (GO:0030852)2.60389137
92myeloid dendritic cell activation (GO:0001773)2.59170499
93antigen receptor-mediated signaling pathway (GO:0050851)2.57832823
94response to laminar fluid shear stress (GO:0034616)2.57766762
95T cell migration (GO:0072678)2.57655054
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57353452
97regulation of interleukin-12 biosynthetic process (GO:0045075)2.56544398
98negative regulation of interleukin-12 production (GO:0032695)2.55796611
99negative regulation of granulocyte differentiation (GO:0030853)2.53783280
100regulation of p38MAPK cascade (GO:1900744)2.53667301
101response to host immune response (GO:0052572)2.52325637
102response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.52325637
103tricarboxylic acid metabolic process (GO:0072350)2.51240202
104phospholipid homeostasis (GO:0055091)2.49983052
105Arp2/3 complex-mediated actin nucleation (GO:0034314)2.47879445
106natural killer cell mediated immunity (GO:0002228)2.47690332
107natural killer cell mediated cytotoxicity (GO:0042267)2.47690332
108response to peptidoglycan (GO:0032494)2.45231225
109positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.41110649
110response to host (GO:0075136)2.40982244
111response to host defenses (GO:0052200)2.40982244
112response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.40982244
113fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.39316037
114B cell receptor signaling pathway (GO:0050853)2.39235893
115oxaloacetate metabolic process (GO:0006107)2.38484925
116regulation of sequestering of triglyceride (GO:0010889)2.38241826
117macrophage activation (GO:0042116)2.36775159
118negative regulation of lipid storage (GO:0010888)2.35710536
119positive regulation of interferon-beta production (GO:0032728)2.34743445
120mature B cell differentiation (GO:0002335)2.33913553
121positive regulation of natural killer cell differentiation (GO:0032825)2.33046450
122negative regulation of cell killing (GO:0031342)2.32618649
123negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.32618649
124peptide catabolic process (GO:0043171)2.30863243
125positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.30160286
126regulation of B cell differentiation (GO:0045577)2.29668563
127plasma lipoprotein particle clearance (GO:0034381)2.29611793
128regulation of phagocytosis (GO:0050764)2.27851753
129regulation of cholesterol homeostasis (GO:2000188)2.26114391
130positive regulation of phagocytosis (GO:0050766)2.25866556
131regulation of fatty acid beta-oxidation (GO:0031998)2.25797632
132interferon-gamma-mediated signaling pathway (GO:0060333)2.24849501
133positive thymic T cell selection (GO:0045059)2.24285836
134microglial cell activation (GO:0001774)2.24094039
135activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.22279249
136fatty acid transmembrane transport (GO:1902001)2.21908276
137vascular endothelial growth factor signaling pathway (GO:0038084)2.21423656
138positive regulation of lipid storage (GO:0010884)2.21029935
139regulation of type I interferon-mediated signaling pathway (GO:0060338)2.19834721
1402-oxoglutarate metabolic process (GO:0006103)2.19787324
141regulation of antigen processing and presentation (GO:0002577)2.19342013
142mature B cell differentiation involved in immune response (GO:0002313)2.19316531
143alpha-linolenic acid metabolic process (GO:0036109)2.18541249
144respiratory burst (GO:0045730)2.17421398
145response to type I interferon (GO:0034340)2.17210052
146negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.16928207
147cell adhesion mediated by integrin (GO:0033627)2.16859799
148regulation of response to interferon-gamma (GO:0060330)2.16779174
149negative regulation of cell size (GO:0045792)2.16122139
150cellular response to zinc ion (GO:0071294)2.16010494
151stress fiber assembly (GO:0043149)2.15875581
152lipopolysaccharide-mediated signaling pathway (GO:0031663)2.15625312
153regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.15584575
154triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.15489629
155endothelial cell chemotaxis (GO:0035767)2.14842379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.58684808
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.06374091
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99755652
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.84211463
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.75074952
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.61130810
7* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52984805
8* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48207512
9* IRF8_27001747_Chip-Seq_BMDM_Mouse2.41209044
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40810786
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40153407
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.39256547
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.38177396
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.31518104
15VDR_21846776_ChIP-Seq_THP-1_Human2.26017449
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24477651
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.24463459
18* MYC_22102868_ChIP-Seq_BL_Human2.23508638
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.23178921
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08173669
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.06928217
22SCL_19346495_ChIP-Seq_HPC-7_Human2.01992891
23* TCF7_22412390_ChIP-Seq_EML_Mouse1.96101056
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.91416957
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.84669719
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.84625344
27* SPI1_23127762_ChIP-Seq_K562_Human1.84108222
28VDR_24763502_ChIP-Seq_THP-1_Human1.82520949
29MAF_26560356_Chip-Seq_TH1_Human1.78325821
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76428323
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74774433
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71846085
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70087327
34* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.69613886
35GATA1_22025678_ChIP-Seq_K562_Human1.67194281
36KDM2B_26808549_Chip-Seq_DND41_Human1.65286228
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64602632
38UTX_26944678_Chip-Seq_JUKART_Human1.64535204
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63532407
40CLOCK_20551151_ChIP-Seq_293T_Human1.61488856
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.61451081
42* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61244975
43LXR_22292898_ChIP-Seq_THP-1_Human1.59124312
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.55643082
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54033933
46* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52354990
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51562557
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.51409602
49SPI1_23547873_ChIP-Seq_NB4_Human1.49326508
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49286960
51VDR_24787735_ChIP-Seq_THP-1_Human1.49064427
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.45834277
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44942860
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41114987
55* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39095318
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.37832740
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35689498
58MYB_26560356_Chip-Seq_TH2_Human1.34594938
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33858324
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.33040835
61GATA1_19941826_ChIP-Seq_K562_Human1.31909062
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30652149
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30407177
64* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.29706538
65PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29122753
66MYB_26560356_Chip-Seq_TH1_Human1.29084562
67FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28877766
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28626772
69RACK7_27058665_Chip-Seq_MCF-7_Human1.28619306
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28310159
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27009917
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.24029876
73* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20438455
74* GATA1_19941827_ChIP-Seq_MEL_Mouse1.19151493
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18165860
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17734089
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17004347
78* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16809775
79RUNX_20019798_ChIP-Seq_JUKART_Human1.16732885
80PU_27001747_Chip-Seq_BMDM_Mouse1.15506287
81CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14424346
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14337638
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13452246
84ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12866958
85* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12696387
86FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12480693
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11778725
88CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11585084
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11528865
90* ATF3_27146783_Chip-Seq_COLON_Human1.11356280
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11277821
92P68_20966046_ChIP-Seq_HELA_Human1.10693392
93P300_27268052_Chip-Seq_Bcells_Human1.10404303
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09781218
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09711885
96GATA2_19941826_ChIP-Seq_K562_Human1.09567406
97BCOR_27268052_Chip-Seq_Bcells_Human1.09269245
98* GATA3_26560356_Chip-Seq_TH2_Human1.09128297
99* NCOR1_26117541_ChIP-Seq_K562_Human1.08295635
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07392473
101TFEB_21752829_ChIP-Seq_HELA_Human1.07027123
102SA1_27219007_Chip-Seq_ERYTHROID_Human1.06807195
103FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06727803
104FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05962726
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05491246
106BCL6_27268052_Chip-Seq_Bcells_Human1.04282302
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04123939
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02669023
109* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02419156
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02399798
111* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02336369
112SPI1_20517297_ChIP-Seq_HL60_Human1.02059944
113PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02021255
114HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01829256
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01484914
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00865467
117STAT1_20625510_ChIP-Seq_HELA_Human1.00665570
118E2F1_20622854_ChIP-Seq_HELA_Human0.98997678
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98201316
120* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97222099
121GATA3_27048872_Chip-Seq_THYMUS_Human0.96298387
122EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96231695
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95612694
124MAF_26560356_Chip-Seq_TH2_Human0.95254926
125KDM2B_26808549_Chip-Seq_JURKAT_Human0.95192937
126CTCF_26484167_Chip-Seq_Bcells_Mouse0.95096278
127GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94925181
128SA1_27219007_Chip-Seq_Bcells_Human0.93211599
129SMC4_20622854_ChIP-Seq_HELA_Human0.92795705

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.30951174
2MP0005058_abnormal_lysosome_morphology3.09775290
3MP0009840_abnormal_foam_cell2.95573843
4MP0003191_abnormal_cellular_cholesterol2.83090112
5MP0003300_gastrointestinal_ulcer2.80847287
6MP0003705_abnormal_hypodermis_morpholog2.46473328
7MP0003436_decreased_susceptibility_to2.38506663
8MP0001835_abnormal_antigen_presentation2.37729053
9MP0003172_abnormal_lysosome_physiology2.33341290
10MP0009278_abnormal_bone_marrow2.32955072
11MP0003763_abnormal_thymus_physiology2.28933192
12MP0005360_urolithiasis2.05194846
13MP0005464_abnormal_platelet_physiology1.95482972
14MP0003724_increased_susceptibility_to1.88742069
15MP0002419_abnormal_innate_immunity1.85289397
16MP0000685_abnormal_immune_system1.77325931
17MP0006082_CNS_inflammation1.75830634
18MP0002138_abnormal_hepatobiliary_system1.73165533
19MP0004947_skin_inflammation1.72462110
20MP0001545_abnormal_hematopoietic_system1.71622990
21MP0005397_hematopoietic_system_phenotyp1.71622990
22MP0003566_abnormal_cell_adhesion1.71480122
23MP0001790_abnormal_immune_system1.68877726
24MP0005387_immune_system_phenotype1.68877726
25MP0004510_myositis1.63683514
26MP0005000_abnormal_immune_tolerance1.61987550
27MP0001800_abnormal_humoral_immune1.60276517
28MP0002452_abnormal_antigen_presenting1.59200212
29MP0010368_abnormal_lymphatic_system1.57130553
30MP0005365_abnormal_bile_salt1.56030125
31MP0005083_abnormal_biliary_tract1.53085712
32MP0005025_abnormal_response_to1.52793573
33MP0002723_abnormal_immune_serum1.52230279
34MP0005451_abnormal_body_composition1.51216249
35MP0008260_abnormal_autophagy1.50321454
36MP0005085_abnormal_gallbladder_physiolo1.50051903
37MP0010352_gastrointestinal_tract_polyps1.39961822
38MP0001873_stomach_inflammation1.38244754
39MP0009785_altered_susceptibility_to1.37978549
40MP0002420_abnormal_adaptive_immunity1.36422665
41MP0002166_altered_tumor_susceptibility1.36176935
42MP0001819_abnormal_immune_cell1.35878911
43MP0003252_abnormal_bile_duct1.35439632
44MP0001533_abnormal_skeleton_physiology1.34895483
45MP0003183_abnormal_peptide_metabolism1.34118330
46MP0010329_abnormal_lipoprotein_level1.33539342
47MP0000604_amyloidosis1.31212510
48MP0008469_abnormal_protein_level1.30205530
49MP0000569_abnormal_digit_pigmentation1.28966003
50MP0004381_abnormal_hair_follicle1.28593556
51MP0010307_abnormal_tumor_latency1.28136768
52MP0006054_spinal_hemorrhage1.27691917
53MP0001845_abnormal_inflammatory_respons1.27576188
54MP0009764_decreased_sensitivity_to1.27550467
55MP0000609_abnormal_liver_physiology1.27500902
56MP0004808_abnormal_hematopoietic_stem1.27130320
57MP0002877_abnormal_melanocyte_morpholog1.25556696
58MP0002139_abnormal_hepatobiliary_system1.25256172
59MP0004130_abnormal_muscle_cell1.24798750
60MP0002396_abnormal_hematopoietic_system1.23631845
61MP0005023_abnormal_wound_healing1.22588539
62MP0010155_abnormal_intestine_physiology1.21817332
63MP0000465_gastrointestinal_hemorrhage1.20382498
64MP0002148_abnormal_hypersensitivity_rea1.20283745
65MP0005671_abnormal_response_to1.19185082
66MP0000689_abnormal_spleen_morphology1.18915435
67MP0005075_abnormal_melanosome_morpholog1.17822350
68MP0010234_abnormal_vibrissa_follicle1.17579488
69MP0000858_altered_metastatic_potential1.17573337
70MP0008875_abnormal_xenobiotic_pharmacok1.17264284
71MP0002254_reproductive_system_inflammat1.13964884
72MP0003828_pulmonary_edema1.13307408
73MP0002398_abnormal_bone_marrow1.11819680
74MP0000343_altered_response_to1.11798152
75MP0000013_abnormal_adipose_tissue1.08902164
76MP0002405_respiratory_system_inflammati1.08833935
77MP0000716_abnormal_immune_system1.08762955
78MP0008438_abnormal_cutaneous_collagen1.08389594
79MP0009643_abnormal_urine_homeostasis1.08008048
80MP0005167_abnormal_blood-brain_barrier1.07853963
81MP0003806_abnormal_nucleotide_metabolis1.07554216
82MP0002933_joint_inflammation1.06307065
83MP0003091_abnormal_cell_migration1.05500092
84MP0005670_abnormal_white_adipose1.04291482
85MP0001853_heart_inflammation1.03317989
86MP0002722_abnormal_immune_system1.02948608
87MP0000703_abnormal_thymus_morphology1.02415496
88MP0005319_abnormal_enzyme/_coenzyme1.01577552
89MP0002132_abnormal_respiratory_system1.01016512
90MP0005310_abnormal_salivary_gland1.00690085
91MP0000598_abnormal_liver_morphology0.99915220
92MP0003656_abnormal_erythrocyte_physiolo0.99334137
93MP0003075_altered_response_to0.98841148
94MP0001958_emphysema0.96411656
95MP0002429_abnormal_blood_cell0.96368281
96MP0003866_abnormal_defecation0.95270878
97MP0004883_abnormal_blood_vessel0.95156483
98MP0008961_abnormal_basal_metabolism0.94201952
99MP0000249_abnormal_blood_vessel0.93100005
100MP0001663_abnormal_digestive_system0.92918281
101MP0001879_abnormal_lymphatic_vessel0.92035562
102MP0000015_abnormal_ear_pigmentation0.91694354
103MP0003045_fibrosis0.90887578
104MP0005164_abnormal_response_to0.90033117
105MP0005166_decreased_susceptibility_to0.89159387
106MP0002118_abnormal_lipid_homeostasis0.88944060
107MP0009333_abnormal_splenocyte_physiolog0.88691594
108MP0005076_abnormal_cell_differentiation0.87148840
109MP0001915_intracranial_hemorrhage0.86454090
110MP0002136_abnormal_kidney_physiology0.84517729
111MP0004185_abnormal_adipocyte_glucose0.84312161
112MP0003448_altered_tumor_morphology0.82493948
113MP0009763_increased_sensitivity_to0.81960742
114MP0002998_abnormal_bone_remodeling0.81178948
115MP0001666_abnormal_nutrient_absorption0.79014156
116MP0002928_abnormal_bile_duct0.78641574
117MP0001851_eye_inflammation0.75768023
118MP0009765_abnormal_xenobiotic_induced0.73778882
119MP0005390_skeleton_phenotype0.72995530
120MP0008004_abnormal_stomach_pH0.72722120
121MP0002693_abnormal_pancreas_physiology0.71598959
122MP0002277_abnormal_respiratory_mucosa0.70794979
123MP0008874_decreased_physiological_sensi0.70311333
124MP0000371_diluted_coat_color0.65835918
125MP0003795_abnormal_bone_structure0.61530663
126MP0001986_abnormal_taste_sensitivity0.59837242
127MP0002332_abnormal_exercise_endurance0.59521400
128MP0000490_abnormal_crypts_of0.57843708

Predicted human phenotypes

RankGene SetZ-score
1Mediastinal lymphadenopathy (HP:0100721)4.09543952
2Increased cerebral lipofuscin (HP:0011813)3.76424958
3Retrobulbar optic neuritis (HP:0100654)3.75654287
4Optic neuritis (HP:0100653)3.75654287
5Abnormal delayed hypersensitivity skin test (HP:0002963)3.65732867
6Meningitis (HP:0001287)3.64896747
7Recurrent cutaneous fungal infections (HP:0011370)3.63701010
8Chronic mucocutaneous candidiasis (HP:0002728)3.63701010
9Vacuolated lymphocytes (HP:0001922)3.59034541
10Systemic lupus erythematosus (HP:0002725)3.57770224
11Recurrent abscess formation (HP:0002722)3.55835230
12Stomatitis (HP:0010280)3.45196254
13Gastrointestinal stroma tumor (HP:0100723)3.44817653
14Dysostosis multiplex (HP:0000943)3.43853221
15Recurrent bacterial skin infections (HP:0005406)3.33420469
16Eczematoid dermatitis (HP:0000976)3.27134165
17Obstructive lung disease (HP:0006536)3.23223793
18Chronic obstructive pulmonary disease (HP:0006510)3.23223793
19Gastrointestinal infarctions (HP:0005244)3.20365771
20Encephalitis (HP:0002383)3.15661306
21Agammaglobulinemia (HP:0004432)3.13559060
22Elevated erythrocyte sedimentation rate (HP:0003565)3.12373504
23Urinary glycosaminoglycan excretion (HP:0003541)3.08023728
24Mucopolysacchariduria (HP:0008155)3.08023728
25Myocardial infarction (HP:0001658)3.07743409
26Axonal loss (HP:0003447)3.07182677
27Autoimmune thrombocytopenia (HP:0001973)3.06572435
28Cerebral aneurysm (HP:0004944)2.97045588
29Increased neuronal autofluorescent lipopigment (HP:0002074)2.94496646
30Pulmonary infiltrates (HP:0002113)2.93762733
31Asymmetric septal hypertrophy (HP:0001670)2.90699821
32Hematochezia (HP:0002573)2.83717398
33Recurrent sinusitis (HP:0011108)2.82753643
34Abnormality of polysaccharide metabolism (HP:0011012)2.81114876
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.81114876
36Abnormality of mucopolysaccharide metabolism (HP:0011020)2.81114876
37Abnormality of liposaccharide metabolism (HP:0010968)2.79805620
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.79805620
39Abnormality of glycolipid metabolism (HP:0010969)2.79805620
40Colitis (HP:0002583)2.79384114
41Urticaria (HP:0001025)2.78742705
42Panhypogammaglobulinemia (HP:0003139)2.78263719
43Recurrent gram-negative bacterial infections (HP:0005420)2.76069511
44Polycythemia (HP:0001901)2.74949025
45Hemoptysis (HP:0002105)2.74650278
46Abnormality of macrophages (HP:0004311)2.74555611
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.72715433
48Recurrent bronchitis (HP:0002837)2.64334537
49Purpura (HP:0000979)2.58786162
50Lymphopenia (HP:0001888)2.58316265
51Glomerulonephritis (HP:0000099)2.55116500
52Myositis (HP:0100614)2.53942561
53Increased connective tissue (HP:0009025)2.49948214
54Chest pain (HP:0100749)2.48585486
55Xanthomatosis (HP:0000991)2.47899433
56Keratoconjunctivitis sicca (HP:0001097)2.46972639
57Complement deficiency (HP:0004431)2.44892931
58Malnutrition (HP:0004395)2.43715833
59Restrictive lung disease (HP:0002091)2.41671739
60Keratoconjunctivitis (HP:0001096)2.40339528
61Abnormality of T cells (HP:0002843)2.39758844
62Spontaneous hematomas (HP:0007420)2.37113902
63T lymphocytopenia (HP:0005403)2.35998783
64Abnormality of cells of the lymphoid lineage (HP:0012140)2.33439134
65Inflammation of the large intestine (HP:0002037)2.33436667
66Recurrent pneumonia (HP:0006532)2.33174401
67Abnormality of T cell physiology (HP:0011840)2.32962664
68Gastrointestinal inflammation (HP:0004386)2.31758321
69Abnormality of the nasal mucosa (HP:0000433)2.30041742
70Hypercholesterolemia (HP:0003124)2.29975091
71Interstitial pulmonary disease (HP:0006530)2.27351949
72Increased CSF protein (HP:0002922)2.25279122
73Cellulitis (HP:0100658)2.25016438
74Increased serum ferritin (HP:0003281)2.24681028
75Abnormality of T cell number (HP:0011839)2.24011432
76Recurrent lower respiratory tract infections (HP:0002783)2.23960354
77Abnormality of complement system (HP:0005339)2.22926298
78Pustule (HP:0200039)2.22622958
79Pulmonary embolism (HP:0002204)2.22127619
80Verrucae (HP:0200043)2.21435973
81Papilloma (HP:0012740)2.21435973
82Nephritis (HP:0000123)2.16688395
83Chronic diarrhea (HP:0002028)2.15280942
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14962336
85Orchitis (HP:0100796)2.14290691
86Aortic aneurysm (HP:0004942)2.13669026
87Deep venous thrombosis (HP:0002625)2.13444112
88Abnormality of the pleura (HP:0002103)2.13439839
89Joint hemorrhage (HP:0005261)2.12805554
90IgM deficiency (HP:0002850)2.11147115
91Retinal atrophy (HP:0001105)2.11115282
92Recurrent viral infections (HP:0004429)2.10271089
93Impaired platelet aggregation (HP:0003540)2.09059414
94Abnormal platelet function (HP:0011869)2.09059414
95Abnormality of iron homeostasis (HP:0011031)2.08006798
96Loss of speech (HP:0002371)2.06304218
97Arthralgia (HP:0002829)2.05833013
98Esophageal varix (HP:0002040)2.05217094
99Recurrent fungal infections (HP:0002841)2.01480662
100Osteomyelitis (HP:0002754)1.99815293
101Premature loss of primary teeth (HP:0006323)1.99333060
102Increased IgM level (HP:0003496)1.98108550
103Hypochromic anemia (HP:0001931)1.97926929
104Gingivitis (HP:0000230)1.97607277
105Vasculitis (HP:0002633)1.97115791
106Anorexia (HP:0002039)1.96757705
107Periodontitis (HP:0000704)1.95877801
108Amyloidosis (HP:0011034)1.95706559
109Nasal polyposis (HP:0100582)1.94912109
110Frequent falls (HP:0002359)1.93720378
111Glomerulopathy (HP:0100820)1.93593205
112Facial diplegia (HP:0001349)1.93262357
113Conjunctival telangiectasia (HP:0000524)1.93104303
114Gangrene (HP:0100758)1.92983872
115IgG deficiency (HP:0004315)1.92441465
116Nonimmune hydrops fetalis (HP:0001790)1.91670950
117Striae distensae (HP:0001065)1.91473989
118Osteolytic defects of the phalanges of the hand (HP:0009771)1.91067226
119Osteolytic defects of the hand bones (HP:0009699)1.91067226
120Pathologic fracture (HP:0002756)1.90945204
121Skin rash (HP:0000988)1.90831425
122Epidermoid cyst (HP:0200040)1.90305593
123Recurrent skin infections (HP:0001581)1.90196464
124Global brain atrophy (HP:0002283)1.90059930
125Leukocytosis (HP:0001974)1.89585554
126Hypoglycemic coma (HP:0001325)1.89222531
127Hand muscle atrophy (HP:0009130)1.88446168
128Abnormality of the vasculature of the conjunctiva (HP:0008054)1.87667856
129Fatigue (HP:0012378)1.86430715
130Emphysema (HP:0002097)1.85969297
131Tetraparesis (HP:0002273)1.85920029
132Distal upper limb amyotrophy (HP:0007149)1.84631696
133Upper limb amyotrophy (HP:0009129)1.84631696
134Peritonitis (HP:0002586)1.83401209
135Hypoalphalipoproteinemia (HP:0003233)1.82454631
136Mucosal telangiectasiae (HP:0100579)1.80455515
137Epistaxis (HP:0000421)1.80279197
138Abnormal platelet volume (HP:0011876)1.79474120
139Aneurysm (HP:0002617)1.79457183
140Nausea (HP:0002018)1.79303047
141Arterial thrombosis (HP:0004420)1.79099351
142Spondylolisthesis (HP:0003302)1.78423415
143Difficulty climbing stairs (HP:0003551)1.78017588
144Chronic otitis media (HP:0000389)1.75581830
145Thoracic kyphosis (HP:0002942)1.75561963
146Peripheral demyelination (HP:0011096)1.74685448
147Increased IgE level (HP:0003212)1.74642324
148Gingival bleeding (HP:0000225)1.74636060
149Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.74517019
150Abnormality of the thoracic spine (HP:0100711)1.73295729
151Cardiomegaly (HP:0001640)1.72767349
152Hyporeflexia of lower limbs (HP:0002600)1.72310668
153Petechiae (HP:0000967)1.71839568
154Prolonged bleeding time (HP:0003010)1.70608065

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.13595384
2TRIB33.56055857
3PKN23.32399926
4TGFBR22.83636079
5MAP4K12.79232821
6MAP2K32.41957707
7RIPK12.21862020
8TTN2.13271447
9TYK22.12823743
10PTK62.08727819
11TBK12.04511552
12KIT1.90227892
13SIK21.85940917
14ZAP701.79320139
15KDR1.78510194
16IRAK31.75766426
17TAOK31.73848254
18TNK21.67048473
19PRPF4B1.65007321
20JAK31.62161819
21LRRK21.61217319
22EEF2K1.60958202
23TXK1.59825500
24JAK11.58690292
25TESK21.56583193
26RIPK41.54729253
27BLK1.54228099
28MAP3K31.53030248
29SCYL21.50264868
30CAMK1D1.47799161
31STK101.47433242
32TIE11.46066585
33FGR1.41810800
34TAOK11.40142652
35FLT31.38710199
36CDC42BPA1.37244940
37CSF1R1.36335049
38BCKDK1.29447783
39MAP3K101.27840434
40PAK41.27389489
41JAK21.27086997
42FGFR41.15851999
43EPHB11.13997831
44HCK1.09717809
45MARK21.07431863
46MAP3K111.07175141
47PRKD21.04100954
48BTK1.02111870
49NME21.01803382
50SIK11.00589081
51PIM11.00393241
52TGFBR10.99301033
53SYK0.98621662
54RPS6KA40.96972894
55CSK0.95355634
56CAMKK10.93576802
57IRAK10.89342184
58MAP3K140.88707117
59MAPK70.87899985
60MAP2K60.85035542
61TESK10.84855974
62CAMK1G0.84408971
63GRK60.83945090
64MAP3K10.83735671
65MAP3K130.82073069
66TLK10.80926844
67MAP2K20.80837691
68PRKCQ0.79672561
69ITK0.78397832
70PDGFRA0.76762617
71ACVR1B0.76641885
72FES0.76041969
73MAPK150.74953295
74BMPR20.74599458
75IKBKB0.74371185
76IKBKE0.73737772
77KSR20.73328854
78PIK3CG0.71659650
79TAOK20.70226839
80MAPK120.69796363
81SMG10.69476215
82RET0.67680421
83PRKCH0.66901651
84CDK60.65145314
85PDK10.63941470
86LCK0.63580526
87SIK30.63552331
88NEK20.62319421
89RPS6KA20.61973895
90CAMKK20.60129538
91IRAK40.59634912
92NEK90.59041488
93MAP3K80.57834128
94RPS6KL10.57785922
95RPS6KC10.57785922
96RPS6KA60.57627769
97EGFR0.56832344
98MAP2K10.56381448
99LYN0.56275156
100FGFR30.56005037
101TEC0.55813048
102ICK0.55507068
103MAP3K20.54005841
104PDPK10.54001455
105LMTK20.51937583
106MAP3K60.51493702
107CHUK0.51087625
108MATK0.50700196
109MTOR0.47630654
110PRKG20.46455244
111PIM20.46176679
112CDK40.45533580
113BMX0.45402354
114MAP3K70.45377928
115EPHA30.45283508
116IRAK20.44777755
117FYN0.44248365
118PDK40.44043472
119PDK30.44043472
120MAPKAPK20.42701967
121PDGFRB0.42222588
122ALK0.41849846
123MARK30.41436612
124STK110.41406793
125MAPK110.41395071
126PTK2B0.41323659
127HIPK20.40787225
128PAK20.40643265
129CDK190.39940860
130SGK30.39580074
131PRKAA20.38729473
132ADRBK20.38590430
133MAPK40.38443168
134STK380.38141952
135TRPM70.38137495
136DYRK1B0.36441084

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.20703001
2Graft-versus-host disease_Homo sapiens_hsa053323.08194755
3Autoimmune thyroid disease_Homo sapiens_hsa053202.87300378
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.66572215
5Staphylococcus aureus infection_Homo sapiens_hsa051502.56225677
6Lysosome_Homo sapiens_hsa041422.55276125
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.51973997
8Asthma_Homo sapiens_hsa053102.39092727
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38561107
10Type I diabetes mellitus_Homo sapiens_hsa049402.34503948
11Leishmaniasis_Homo sapiens_hsa051402.07556795
12Osteoclast differentiation_Homo sapiens_hsa043802.05942751
13Other glycan degradation_Homo sapiens_hsa005112.01552744
14Caffeine metabolism_Homo sapiens_hsa002321.76275104
15B cell receptor signaling pathway_Homo sapiens_hsa046621.68062819
16Fatty acid degradation_Homo sapiens_hsa000711.62840463
17Rheumatoid arthritis_Homo sapiens_hsa053231.60953401
18Legionellosis_Homo sapiens_hsa051341.60608332
19Viral myocarditis_Homo sapiens_hsa054161.59679789
20Antigen processing and presentation_Homo sapiens_hsa046121.56431060
21Tuberculosis_Homo sapiens_hsa051521.49193323
22Complement and coagulation cascades_Homo sapiens_hsa046101.45341697
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43148728
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42101719
25T cell receptor signaling pathway_Homo sapiens_hsa046601.41993618
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40600922
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36860337
28Nitrogen metabolism_Homo sapiens_hsa009101.36144456
29Pertussis_Homo sapiens_hsa051331.36114583
30Toxoplasmosis_Homo sapiens_hsa051451.32280264
31Insulin resistance_Homo sapiens_hsa049311.29782555
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29545347
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.23350686
34PPAR signaling pathway_Homo sapiens_hsa033201.21772518
35Apoptosis_Homo sapiens_hsa042101.20803955
36Carbohydrate digestion and absorption_Homo sapiens_hsa049731.17416700
37Chronic myeloid leukemia_Homo sapiens_hsa052201.16999494
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.15559372
39Galactose metabolism_Homo sapiens_hsa000521.14936459
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.14797220
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12622113
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.12399497
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08463418
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07903432
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07618747
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07120747
47ABC transporters_Homo sapiens_hsa020101.06335924
48Type II diabetes mellitus_Homo sapiens_hsa049301.01730012
49TNF signaling pathway_Homo sapiens_hsa046681.01683739
50Starch and sucrose metabolism_Homo sapiens_hsa005001.01214562
51Pentose and glucuronate interconversions_Homo sapiens_hsa000401.00338116
52Acute myeloid leukemia_Homo sapiens_hsa052210.98572169
53Platelet activation_Homo sapiens_hsa046110.98488911
54African trypanosomiasis_Homo sapiens_hsa051430.98250332
55Arginine biosynthesis_Homo sapiens_hsa002200.95521900
56Fructose and mannose metabolism_Homo sapiens_hsa000510.95299968
57Influenza A_Homo sapiens_hsa051640.94887391
58Measles_Homo sapiens_hsa051620.94406577
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92881765
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.92716640
61Malaria_Homo sapiens_hsa051440.92662647
62Fat digestion and absorption_Homo sapiens_hsa049750.92343363
63Carbon metabolism_Homo sapiens_hsa012000.91640234
64Fatty acid metabolism_Homo sapiens_hsa012120.91368862
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90930622
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87947780
67Phagosome_Homo sapiens_hsa041450.87152368
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84634175
69Renin-angiotensin system_Homo sapiens_hsa046140.84055109
70VEGF signaling pathway_Homo sapiens_hsa043700.82759258
71Bile secretion_Homo sapiens_hsa049760.81189166
72Salmonella infection_Homo sapiens_hsa051320.79932989
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79902768
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79362801
75Amoebiasis_Homo sapiens_hsa051460.78098320
76Shigellosis_Homo sapiens_hsa051310.77744187
77Pentose phosphate pathway_Homo sapiens_hsa000300.75260070
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73632059
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72040301
80Pancreatic cancer_Homo sapiens_hsa052120.70049998
81HIF-1 signaling pathway_Homo sapiens_hsa040660.69683748
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.69226105
83Lysine degradation_Homo sapiens_hsa003100.67953327
84Hematopoietic cell lineage_Homo sapiens_hsa046400.67762994
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.67753213
86Small cell lung cancer_Homo sapiens_hsa052220.67222016
87Hepatitis C_Homo sapiens_hsa051600.65630120
88Tryptophan metabolism_Homo sapiens_hsa003800.65000387
89Endocytosis_Homo sapiens_hsa041440.64662445
90Insulin signaling pathway_Homo sapiens_hsa049100.64547035
91Epstein-Barr virus infection_Homo sapiens_hsa051690.63679168
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.62565369
93mTOR signaling pathway_Homo sapiens_hsa041500.62524192
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62511678
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62010519
96Chemokine signaling pathway_Homo sapiens_hsa040620.61292345
97Hepatitis B_Homo sapiens_hsa051610.61001104
98Glycerolipid metabolism_Homo sapiens_hsa005610.60179169
99Primary immunodeficiency_Homo sapiens_hsa053400.59680598
100Selenocompound metabolism_Homo sapiens_hsa004500.59288791
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.59055360
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59009587
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58594416
104Prolactin signaling pathway_Homo sapiens_hsa049170.58541368
105Propanoate metabolism_Homo sapiens_hsa006400.58431831
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57700047
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57298731
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55340170
109Non-small cell lung cancer_Homo sapiens_hsa052230.54969236
110Drug metabolism - other enzymes_Homo sapiens_hsa009830.54475285
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53973585
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53771148
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.53519969
114Prion diseases_Homo sapiens_hsa050200.52711110
115Biosynthesis of amino acids_Homo sapiens_hsa012300.52657533
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.51635137
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50819722
118Herpes simplex infection_Homo sapiens_hsa051680.49784190
119Inositol phosphate metabolism_Homo sapiens_hsa005620.48982296
120Arachidonic acid metabolism_Homo sapiens_hsa005900.48446271
121FoxO signaling pathway_Homo sapiens_hsa040680.47886794
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.46092945
123Notch signaling pathway_Homo sapiens_hsa043300.42897915
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.42780590
125HTLV-I infection_Homo sapiens_hsa051660.42313354
126Collecting duct acid secretion_Homo sapiens_hsa049660.41180872
127Systemic lupus erythematosus_Homo sapiens_hsa053220.39769847
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36568166
129GnRH signaling pathway_Homo sapiens_hsa049120.36496004
130Viral carcinogenesis_Homo sapiens_hsa052030.34138591
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32806834
132Sulfur relay system_Homo sapiens_hsa041220.32087476
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31014247
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30781454
135Renal cell carcinoma_Homo sapiens_hsa052110.30369264
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29538244
137Choline metabolism in cancer_Homo sapiens_hsa052310.29319953
138MAPK signaling pathway_Homo sapiens_hsa040100.29191814

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