TBC1D22B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.49563622
2COPI coating of Golgi vesicle (GO:0048205)4.98508009
3Golgi transport vesicle coating (GO:0048200)4.98508009
4protoporphyrinogen IX biosynthetic process (GO:0006782)4.52626991
5negative regulation of erythrocyte differentiation (GO:0045647)4.46255479
63-UTR-mediated mRNA stabilization (GO:0070935)4.15073693
7synaptic vesicle maturation (GO:0016188)3.90582735
8erythrocyte maturation (GO:0043249)3.77768068
9positive thymic T cell selection (GO:0045059)3.71338257
10pre-miRNA processing (GO:0031054)3.58615126
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.54185490
12peptidyl-lysine dimethylation (GO:0018027)3.52230469
13modulation by symbiont of host cellular process (GO:0044068)3.47246509
14erythrocyte development (GO:0048821)3.41321698
15regulation of response to osmotic stress (GO:0047484)3.40041460
16oxygen transport (GO:0015671)3.39542859
17regulation of ARF protein signal transduction (GO:0032012)3.37459923
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.36328597
19negative regulation of cell killing (GO:0031342)3.36328597
20maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.32511990
21positive regulation of histone deacetylation (GO:0031065)3.32217871
22activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.30038328
23modulation by virus of host process (GO:0019054)3.29866154
24positive T cell selection (GO:0043368)3.29231646
25hemoglobin metabolic process (GO:0020027)3.28273188
26protein retention in ER lumen (GO:0006621)3.28144106
27regulation of RNA export from nucleus (GO:0046831)3.27851811
28thymic T cell selection (GO:0045061)3.27005884
29retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.26291611
30sodium ion export (GO:0071436)3.25464067
31glandular epithelial cell development (GO:0002068)3.24774772
32cellular response to virus (GO:0098586)3.23885092
33response to muramyl dipeptide (GO:0032495)3.17538159
34positive regulation of nuclease activity (GO:0032075)3.16947369
35embryonic process involved in female pregnancy (GO:0060136)3.16867284
36porphyrin-containing compound biosynthetic process (GO:0006779)3.13232217
37locomotory exploration behavior (GO:0035641)3.12050905
38regulation of NFAT protein import into nucleus (GO:0051532)3.09907054
39regulation of nucleobase-containing compound transport (GO:0032239)3.09329778
40lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08662591
41NIK/NF-kappaB signaling (GO:0038061)3.06437821
42regulation of early endosome to late endosome transport (GO:2000641)3.05530903
43type B pancreatic cell development (GO:0003323)3.03386022
44histone H3-K36 demethylation (GO:0070544)3.01818097
45gas transport (GO:0015669)3.01675066
46regulation of ARF GTPase activity (GO:0032312)3.01099778
47neutrophil activation involved in immune response (GO:0002283)3.01071639
48response to peptidoglycan (GO:0032494)3.00115362
49glucocorticoid receptor signaling pathway (GO:0042921)2.98471528
50cytoplasmic mRNA processing body assembly (GO:0033962)2.97835022
51pinocytosis (GO:0006907)2.96297746
52signal complex assembly (GO:0007172)2.93501541
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.92251772
54regulation of chromatin binding (GO:0035561)2.91642562
55intracellular estrogen receptor signaling pathway (GO:0030520)2.89241379
56regulation of nuclease activity (GO:0032069)2.88727954
57regulation of necroptotic process (GO:0060544)2.87673661
58cellular hyperosmotic response (GO:0071474)2.87189825
59synaptic vesicle docking involved in exocytosis (GO:0016081)2.86658087
60T cell selection (GO:0045058)2.85749322
61mitotic chromosome condensation (GO:0007076)2.85360534
62negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.83151487
63negative regulation of cell size (GO:0045792)2.82541366
64positive regulation of Rap GTPase activity (GO:0032854)2.81366478
65positive regulation of gene expression, epigenetic (GO:0045815)2.80858048
66regulation of defense response to virus by virus (GO:0050690)2.80715957
67positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.80380802
68nuclear pore complex assembly (GO:0051292)2.80334494
69cytoskeletal anchoring at plasma membrane (GO:0007016)2.79183041
70vesicle coating (GO:0006901)2.78495813
71regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77407545
72histone H2A monoubiquitination (GO:0035518)2.77068449
73negative T cell selection (GO:0043383)2.76328985
74negative regulation of necroptotic process (GO:0060546)2.74594939
75germinal center formation (GO:0002467)2.72613102
76stress granule assembly (GO:0034063)2.69886452
77negative thymic T cell selection (GO:0045060)2.69061209
78columnar/cuboidal epithelial cell development (GO:0002066)2.67936230
79regulation of gamma-delta T cell differentiation (GO:0045586)2.66821334
80intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.63305638
81corticosteroid receptor signaling pathway (GO:0031958)2.61672287
82regulation of histone H3-K27 methylation (GO:0061085)2.59990701
83histone H4-K12 acetylation (GO:0043983)2.58706003
84heme biosynthetic process (GO:0006783)2.58623284
85megakaryocyte development (GO:0035855)2.58100178
86DNA unwinding involved in DNA replication (GO:0006268)2.57759754
87pentose-phosphate shunt (GO:0006098)2.57090666
88mRNA stabilization (GO:0048255)2.54935724
89RNA stabilization (GO:0043489)2.54935724
90regulation of synaptic vesicle exocytosis (GO:2000300)2.54359372
91positive regulation of gamma-delta T cell activation (GO:0046645)2.52540970
92regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.52183726
93cellular response to arsenic-containing substance (GO:0071243)2.52086249
94negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.51495922
95positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.51211405
96ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.50506094
97myeloid cell development (GO:0061515)2.50339940
98positive regulation of B cell differentiation (GO:0045579)2.50315091
99activation of MAPKKK activity (GO:0000185)2.50243648
100regulation of clathrin-mediated endocytosis (GO:2000369)2.48467051
101endoplasmic reticulum unfolded protein response (GO:0030968)2.48131786
102porphyrin-containing compound metabolic process (GO:0006778)2.47742269
103negative regulation of viral release from host cell (GO:1902187)2.47523289
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.47047015
105granulocyte activation (GO:0036230)2.46272920
106tetrapyrrole biosynthetic process (GO:0033014)2.46184429
107antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.45929988
108antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45929988
109positive regulation by symbiont of host defense response (GO:0052509)2.45422536
110modulation by symbiont of host defense response (GO:0052031)2.45422536
111modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.45422536
112modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.45422536
113positive regulation by organism of defense response of other organism involved in symbiotic interact2.45422536
114modulation by symbiont of host immune response (GO:0052553)2.45422536
115regulation of superoxide anion generation (GO:0032928)2.44435253
116regulation of Rap GTPase activity (GO:0032317)2.44060836
117negative regulation of histone methylation (GO:0031061)2.42563986
118positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.41950785
119pore complex assembly (GO:0046931)2.41554943
120protein export from nucleus (GO:0006611)2.40634747
121epithelial cell fate commitment (GO:0072148)2.40629991
122granulocyte differentiation (GO:0030851)2.40413702
123myeloid dendritic cell differentiation (GO:0043011)2.40274544
124response to arsenic-containing substance (GO:0046685)2.39801077
125negative regulation of nucleotide catabolic process (GO:0030812)2.39456398
126macrophage activation involved in immune response (GO:0002281)2.38957414
127regulation of gamma-delta T cell activation (GO:0046643)2.38358065
128T cell migration (GO:0072678)2.38219595
129definitive hemopoiesis (GO:0060216)2.37876974
130cellular response to unfolded protein (GO:0034620)2.36974238
131layer formation in cerebral cortex (GO:0021819)2.36829838
132activation of protein kinase A activity (GO:0034199)2.34929353
133positive regulation of lamellipodium assembly (GO:0010592)2.34571436
134positive regulation of RNA splicing (GO:0033120)2.34123023
135poly(A)+ mRNA export from nucleus (GO:0016973)2.32585709
136histone H3-K4 methylation (GO:0051568)2.32404182
137histone H4-K16 acetylation (GO:0043984)2.32299138
138regulation of synaptic vesicle transport (GO:1902803)2.32025117
139membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.30696849
140localization within membrane (GO:0051668)2.29647781
141COPII vesicle coating (GO:0048208)2.29571477
142vesicle transport along microtubule (GO:0047496)2.29469106
143JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.29027047
144protein localization to endosome (GO:0036010)2.27855765
145ER-nucleus signaling pathway (GO:0006984)2.26718824
146tolerance induction (GO:0002507)2.26478495
147peptidyl-threonine phosphorylation (GO:0018107)2.26295535
148positive regulation of protein deacetylation (GO:0090312)2.26273119
149protein maturation by protein folding (GO:0022417)2.25428597
150peptidyl-threonine modification (GO:0018210)2.25172012
151NADPH regeneration (GO:0006740)2.24537453
152cellular response to topologically incorrect protein (GO:0035967)2.24062855
153positive regulation of lamellipodium organization (GO:1902745)2.23744752
154cellular response to thyroid hormone stimulus (GO:0097067)2.23700911
155nuclear pore organization (GO:0006999)2.22303203
156regulation of mast cell degranulation (GO:0043304)2.21417228
157regulation of erythrocyte differentiation (GO:0045646)2.21208420
158regulation of leukocyte degranulation (GO:0043300)2.20749175
159insulin secretion (GO:0030073)2.20619853
160NLS-bearing protein import into nucleus (GO:0006607)2.20460124
161negative regulation of cytokine production involved in immune response (GO:0002719)2.20104303
162regulation of interleukin-2 biosynthetic process (GO:0045076)2.19693479
163positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.19524927
164dosage compensation (GO:0007549)2.19078552
165negative regulation of GTPase activity (GO:0034260)2.18691681
166negative regulation of GTP catabolic process (GO:0033125)2.18691681
167positive regulation of Cdc42 GTPase activity (GO:0043089)2.18535606
168negative regulation of meiosis (GO:0045835)2.18260327
169glycosphingolipid catabolic process (GO:0046479)2.17625612
170regulation of chronic inflammatory response (GO:0002676)2.17332632
171histone lysine demethylation (GO:0070076)2.16612516
172cell communication by electrical coupling (GO:0010644)2.16568411
173negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.16528238
174spliceosomal tri-snRNP complex assembly (GO:0000244)2.16227376
175L-alpha-amino acid transmembrane transport (GO:1902475)2.15403179
176histone H4-K8 acetylation (GO:0043982)2.15182105
177histone H4-K5 acetylation (GO:0043981)2.15182105
178histone demethylation (GO:0016577)2.14919860
179negative regulation of glial cell proliferation (GO:0060253)2.14894445
180negative regulation of potassium ion transmembrane transport (GO:1901380)2.14865588
181antigen processing and presentation via MHC class Ib (GO:0002475)2.14651199
182regulation of type I interferon-mediated signaling pathway (GO:0060338)2.14547015
183nerve growth factor signaling pathway (GO:0038180)2.14414896
184stress fiber assembly (GO:0043149)2.13153613
185cerebellar Purkinje cell layer development (GO:0021680)2.11988096
186cellular potassium ion homeostasis (GO:0030007)2.11962039
187intestinal epithelial cell development (GO:0060576)2.11865886
188G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.11267343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.08184966
2MYC_22102868_ChIP-Seq_BL_Human4.07475900
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.11516670
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90087002
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.84700358
6KDM2B_26808549_Chip-Seq_DND41_Human2.84402272
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.78185149
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.75681152
9TCF7_22412390_ChIP-Seq_EML_Mouse2.73789797
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.67688033
11KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.56881767
12VDR_21846776_ChIP-Seq_THP-1_Human2.56183520
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.41997001
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.41743246
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.40308179
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.29063143
17STAT6_21828071_ChIP-Seq_BEAS2B_Human2.27702300
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.25183270
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11591408
20ZFP281_27345836_Chip-Seq_ESCs_Mouse2.09829714
21UTX_26944678_Chip-Seq_JUKART_Human2.07327482
22LXR_22292898_ChIP-Seq_THP-1_Human2.05265690
23* KDM2B_26808549_Chip-Seq_K562_Human2.05074741
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00898482
25KDM2B_26808549_Chip-Seq_JURKAT_Human1.97169456
26DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.93859591
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91861538
28* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.91145775
29SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87003209
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81625021
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.80737589
32MAF_26560356_Chip-Seq_TH1_Human1.78584150
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.77308590
34GATA1_22025678_ChIP-Seq_K562_Human1.71299752
35* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.69659946
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68915976
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.62965816
38SPI1_23127762_ChIP-Seq_K562_Human1.62731832
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.62049365
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61927481
41GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.60635905
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59591210
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59496408
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.58421140
45RACK7_27058665_Chip-Seq_MCF-7_Human1.58227285
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.58010534
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57871907
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57265664
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57011460
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56710920
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55579794
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55057893
53GATA1_22383799_ChIP-Seq_G1ME_Mouse1.52427103
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51445175
55ZNF263_19887448_ChIP-Seq_K562_Human1.49919231
56CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.49728964
57DROSHA_22980978_ChIP-Seq_HELA_Human1.48688815
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.48348463
59CREB1_26743006_Chip-Seq_LNCaP_Human1.44547338
60SMC4_20622854_ChIP-Seq_HELA_Human1.44222730
61P68_20966046_ChIP-Seq_HELA_Human1.43124954
62TFEB_21752829_ChIP-Seq_HELA_Human1.43084374
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41425929
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.38217153
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37725089
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37104451
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36164640
68* GATA2_19941826_ChIP-Seq_K562_Human1.36138683
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35360824
70VDR_24763502_ChIP-Seq_THP-1_Human1.34913155
71SPI1_23547873_ChIP-Seq_NB4_Human1.33958379
72* MYB_26560356_Chip-Seq_TH2_Human1.33550290
73CLOCK_20551151_ChIP-Seq_293T_Human1.32872993
74STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31159225
75PKCTHETA_26484144_Chip-Seq_BREAST_Human1.30733038
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.30693004
77* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27715871
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26745146
79CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26447370
80IRF8_27001747_Chip-Seq_BMDM_Mouse1.25249227
81CIITA_25753668_ChIP-Seq_RAJI_Human1.24713599
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.24214305
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24159944
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22427819
85* MYB_26560356_Chip-Seq_TH1_Human1.22255392
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20197974
87MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20115197
88RUNX1_27514584_Chip-Seq_MCF-7_Human1.19954500
89CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19241903
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18873640
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18431934
92FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.18301390
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.17754765
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17403698
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17384605
96TP63_17297297_ChIP-ChIP_HaCaT_Human1.17152072
97NCOR1_26117541_ChIP-Seq_K562_Human1.16827490
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16730342
99ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16112394
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.15655787
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15509348
102TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.15384985
103MAF_26560356_Chip-Seq_TH2_Human1.13992173
104KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12899557
105* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12586370
106RUNX_20019798_ChIP-Seq_JUKART_Human1.12272083
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12122663
108NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10867512
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09994414
110REST_21632747_ChIP-Seq_MESCs_Mouse1.07187453
111RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07066449
112RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06820752
113IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06682369
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.06477641
115ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06334066
116MYC_18555785_ChIP-Seq_MESCs_Mouse1.05819178
117ATF3_27146783_Chip-Seq_COLON_Human1.05152427
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04515086
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03334408
120GATA1_19941827_ChIP-Seq_MEL_Mouse1.02420521
121REST_18959480_ChIP-ChIP_MESCs_Mouse1.01586537
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01289133
123TET1_21490601_ChIP-Seq_MESCs_Mouse1.01054396
124OCT4_19829295_ChIP-Seq_ESCs_Human1.00798695
125PHF8_20622854_ChIP-Seq_HELA_Human1.00782571
126* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00294714
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99726541
128FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99138844
129* GATA3_27048872_Chip-Seq_THYMUS_Human0.98777329
130CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98314426
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.98148017
132RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97875246
133MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97850065
134PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97544461
135TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97309726
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97083985
137TP63_22573176_ChIP-Seq_HFKS_Human0.96695236
138* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96616847
139* GATA1_19941826_ChIP-Seq_K562_Human0.96487133
140ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96411816
141XRN2_22483619_ChIP-Seq_HELA_Human0.96106453
142HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95682902
143MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95151258
144SCL_19346495_ChIP-Seq_HPC-7_Human0.94666943
145BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94445756
146SA1_27219007_Chip-Seq_ERYTHROID_Human0.93568709
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93286257
148NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92904747
149CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92395102
150RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91595179
151NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90709102
152TP53_23651856_ChIP-Seq_MEFs_Mouse0.90325885

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.36462682
2MP0003656_abnormal_erythrocyte_physiolo4.00548098
3MP0004859_abnormal_synaptic_plasticity3.31834903
4MP0003283_abnormal_digestive_organ3.23386266
5MP0008961_abnormal_basal_metabolism3.07263382
6MP0003436_decreased_susceptibility_to2.80326443
7MP0002877_abnormal_melanocyte_morpholog2.68112722
8MP0005076_abnormal_cell_differentiation2.60952284
9MP0003300_gastrointestinal_ulcer2.53450285
10MP0002909_abnormal_adrenal_gland2.44691371
11MP0002653_abnormal_ependyma_morphology2.35999704
12MP0004147_increased_porphyrin_level2.21654571
13MP0005083_abnormal_biliary_tract2.21056536
14MP0008260_abnormal_autophagy2.19620931
15MP0005397_hematopoietic_system_phenotyp2.17452168
16MP0001545_abnormal_hematopoietic_system2.17452168
17MP0009840_abnormal_foam_cell2.16140473
18MP0004947_skin_inflammation2.14178014
19MP0001849_ear_inflammation2.10152548
20MP0003763_abnormal_thymus_physiology2.07630786
21MP0003172_abnormal_lysosome_physiology2.06806468
22MP0000678_abnormal_parathyroid_gland2.00896543
23MP0003787_abnormal_imprinting1.96163748
24MP0009780_abnormal_chondrocyte_physiolo1.93411266
25MP0002693_abnormal_pancreas_physiology1.92456664
26MP0004858_abnormal_nervous_system1.86226014
27MP0005464_abnormal_platelet_physiology1.85835219
28MP0000569_abnormal_digit_pigmentation1.83332921
29MP0004264_abnormal_extraembryonic_tissu1.82047747
30MP0005000_abnormal_immune_tolerance1.81914271
31MP0009785_altered_susceptibility_to1.81186647
32MP0004043_abnormal_pH_regulation1.81070020
33MP0004233_abnormal_muscle_weight1.77428432
34MP0005025_abnormal_response_to1.75598987
35MP0001944_abnormal_pancreas_morphology1.75082652
36MP0003453_abnormal_keratinocyte_physiol1.74392010
37MP0001835_abnormal_antigen_presentation1.74336066
38MP0003191_abnormal_cellular_cholesterol1.73099381
39MP0002419_abnormal_innate_immunity1.71176616
40MP0003303_peritoneal_inflammation1.69745981
41MP0010352_gastrointestinal_tract_polyps1.64203919
42MP0003866_abnormal_defecation1.63232434
43MP0004270_analgesia1.61023796
44MP0005310_abnormal_salivary_gland1.60562497
45MP0005387_immune_system_phenotype1.55871930
46MP0001790_abnormal_immune_system1.55871930
47MP0000858_altered_metastatic_potential1.55451566
48MP0002148_abnormal_hypersensitivity_rea1.54353343
49MP0003221_abnormal_cardiomyocyte_apopto1.52948782
50MP0002452_abnormal_antigen_presenting1.51843088
51MP0001819_abnormal_immune_cell1.49502102
52MP0002420_abnormal_adaptive_immunity1.49437762
53MP0000003_abnormal_adipose_tissue1.49390143
54MP0001853_heart_inflammation1.47838506
55MP0009278_abnormal_bone_marrow1.47139389
56MP0001800_abnormal_humoral_immune1.46658618
57MP0002723_abnormal_immune_serum1.45471147
58MP0008057_abnormal_DNA_replication1.41609981
59MP0003183_abnormal_peptide_metabolism1.39555183
60MP0002405_respiratory_system_inflammati1.38998799
61MP0000703_abnormal_thymus_morphology1.38820645
62MP0004510_myositis1.37321157
63MP0002132_abnormal_respiratory_system1.36398285
64MP0003635_abnormal_synaptic_transmissio1.35293262
65MP0002429_abnormal_blood_cell1.33425526
66MP0000689_abnormal_spleen_morphology1.32701753
67MP0003119_abnormal_digestive_system1.28437254
68MP0004185_abnormal_adipocyte_glucose1.27811355
69MP0002396_abnormal_hematopoietic_system1.22400350
70MP0008569_lethality_at_weaning1.19235916
71MP0006082_CNS_inflammation1.12694926
72MP0003693_abnormal_embryo_hatching1.11730222
73MP0004811_abnormal_neuron_physiology1.11176951
74MP0003646_muscle_fatigue1.10853606
75MP0005501_abnormal_skin_physiology1.09775419
76MP0003045_fibrosis1.09488001
77MP0002084_abnormal_developmental_patter1.09289935
78MP0002089_abnormal_postnatal_growth/wei1.09179625
79MP0001873_stomach_inflammation1.08577538
80MP0004885_abnormal_endolymph1.08080900
81MP0002796_impaired_skin_barrier1.07805799
82MP0002398_abnormal_bone_marrow1.05655621
83MP0001845_abnormal_inflammatory_respons1.05151490
84MP0001730_embryonic_growth_arrest1.03706159
85MP0004957_abnormal_blastocyst_morpholog1.03227336
86MP0000313_abnormal_cell_death1.03215892
87MP0002234_abnormal_pharynx_morphology1.01971508
88MP0000490_abnormal_crypts_of1.01463336
89MP0003091_abnormal_cell_migration1.00354642
90MP0001533_abnormal_skeleton_physiology0.99660649
91MP0001915_intracranial_hemorrhage0.99325672
92MP0003950_abnormal_plasma_membrane0.99202303
93MP0002019_abnormal_tumor_incidence0.98792969
94MP0003890_abnormal_embryonic-extraembry0.98056782
95MP0000013_abnormal_adipose_tissue0.97454065
96MP0000604_amyloidosis0.96619676
97MP0009703_decreased_birth_body0.96389626
98MP0000955_abnormal_spinal_cord0.95963068
99MP0002063_abnormal_learning/memory/cond0.94760037
100MP0001348_abnormal_lacrimal_gland0.94483110
101MP0005646_abnormal_pituitary_gland0.93328643
102MP0009931_abnormal_skin_appearance0.93256202
103MP0002085_abnormal_embryonic_tissue0.93125400
104MP0009672_abnormal_birth_weight0.92867229
105MP0003724_increased_susceptibility_to0.92741032
106MP0003121_genomic_imprinting0.92432189
107MP0000343_altered_response_to0.91560312
108MP0008877_abnormal_DNA_methylation0.90365026
109MP0002078_abnormal_glucose_homeostasis0.90361146
110MP0005384_cellular_phenotype0.88417392
111MP0003075_altered_response_to0.88250788
112MP0003448_altered_tumor_morphology0.88135099
113MP0001216_abnormal_epidermal_layer0.85847117
114MP0005375_adipose_tissue_phenotype0.85705308
115MP0009333_abnormal_splenocyte_physiolog0.85653023
116MP0009763_increased_sensitivity_to0.85648660
117MP0000350_abnormal_cell_proliferation0.85427041
118MP0003122_maternal_imprinting0.85101873
119MP0001697_abnormal_embryo_size0.84051353
120MP0003111_abnormal_nucleus_morphology0.83969918
121MP0005220_abnormal_exocrine_pancreas0.83913919
122MP0000462_abnormal_digestive_system0.83839554
123MP0010094_abnormal_chromosome_stability0.83615098
124MP0004808_abnormal_hematopoietic_stem0.83542462
125MP0002733_abnormal_thermal_nociception0.83179421
126MP0008469_abnormal_protein_level0.82895253
127MP0010307_abnormal_tumor_latency0.82544548
128MP0003329_amyloid_beta_deposits0.81858405
129MP0002166_altered_tumor_susceptibility0.81488293
130MP0001765_abnormal_ion_homeostasis0.81363571
131MP0003566_abnormal_cell_adhesion0.80019996
132MP0008007_abnormal_cellular_replicative0.79876379
133MP0000465_gastrointestinal_hemorrhage0.79511484
134MP0002998_abnormal_bone_remodeling0.79357640
135MP0005380_embryogenesis_phenotype0.78606463
136MP0001672_abnormal_embryogenesis/_devel0.78606463
137MP0003123_paternal_imprinting0.78273082
138MP0003705_abnormal_hypodermis_morpholog0.77868002
139MP0002086_abnormal_extraembryonic_tissu0.77824867
140MP0003984_embryonic_growth_retardation0.77073290
141MP0005645_abnormal_hypothalamus_physiol0.76937448
142MP0002088_abnormal_embryonic_growth/wei0.75638615
143MP0002080_prenatal_lethality0.73520882
144MP0000371_diluted_coat_color0.72366869
145MP0010234_abnormal_vibrissa_follicle0.70527164
146MP0001502_abnormal_circadian_rhythm0.69458594
147MP0000733_abnormal_muscle_development0.68968541
148MP0005671_abnormal_response_to0.67934798
149MP0003077_abnormal_cell_cycle0.67582594
150MP0000716_abnormal_immune_system0.67125262
151MP0000428_abnormal_craniofacial_morphol0.65943716
152MP0002722_abnormal_immune_system0.65542852
153MP0003879_abnormal_hair_cell0.65482375
154MP0000685_abnormal_immune_system0.65403155
155MP0005621_abnormal_cell_physiology0.64978997
156MP0001970_abnormal_pain_threshold0.64629267
157MP0008770_decreased_survivor_rate0.64573131
158MP0002928_abnormal_bile_duct0.64553455
159MP0010155_abnormal_intestine_physiology0.64411896
160MP0005058_abnormal_lysosome_morphology0.64249094
161MP0002269_muscular_atrophy0.63825808

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)4.75672189
2Reticulocytosis (HP:0001923)4.23045032
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.72105613
4Hyperacusis (HP:0010780)3.61200194
5Poikilocytosis (HP:0004447)3.57406077
6Papilledema (HP:0001085)3.38524974
7Cholecystitis (HP:0001082)3.36884289
8Abnormal gallbladder physiology (HP:0012438)3.36884289
9Cholelithiasis (HP:0001081)3.24622691
10Polycythemia (HP:0001901)3.24367178
11Recurrent viral infections (HP:0004429)3.19487088
12Autoimmune hemolytic anemia (HP:0001890)3.16329094
13Abnormality of the fingertips (HP:0001211)3.09548815
14Autoimmune thrombocytopenia (HP:0001973)3.01584241
15Abnormality of reticulocytes (HP:0004312)2.99707900
16Eczematoid dermatitis (HP:0000976)2.91109792
17Macroorchidism (HP:0000053)2.90472524
18Increased cerebral lipofuscin (HP:0011813)2.78194773
19Abnormality of macrophages (HP:0004311)2.77051765
20Abnormal gallbladder morphology (HP:0012437)2.74576731
21Centrally nucleated skeletal muscle fibers (HP:0003687)2.74491200
22Visual hallucinations (HP:0002367)2.72610288
23Hypertensive crisis (HP:0100735)2.69352118
24Insomnia (HP:0100785)2.67826809
25Slow saccadic eye movements (HP:0000514)2.61522601
26Recurrent bacterial skin infections (HP:0005406)2.56501466
27Recurrent abscess formation (HP:0002722)2.51061167
28Abnormality of the lower motor neuron (HP:0002366)2.49011099
29Neoplasm of the heart (HP:0100544)2.46414193
30Large for gestational age (HP:0001520)2.44374360
31Hyperinsulinemic hypoglycemia (HP:0000825)2.41760108
32Increased neuronal autofluorescent lipopigment (HP:0002074)2.37776172
33Elfin facies (HP:0004428)2.32314696
34Ependymoma (HP:0002888)2.29888117
35Increased IgM level (HP:0003496)2.29673476
36Microcytic anemia (HP:0001935)2.28330200
37Abnormality of glycosphingolipid metabolism (HP:0004343)2.28127726
38Abnormality of glycolipid metabolism (HP:0010969)2.28127726
39Abnormality of liposaccharide metabolism (HP:0010968)2.28127726
40Obstructive lung disease (HP:0006536)2.28021373
41Chronic obstructive pulmonary disease (HP:0006510)2.28021373
42Abnormality of the astrocytes (HP:0100707)2.27966955
43Astrocytoma (HP:0009592)2.27966955
44Hypochromic microcytic anemia (HP:0004840)2.27538223
45Hand muscle atrophy (HP:0009130)2.25728611
46Cerebral aneurysm (HP:0004944)2.25485912
47Increased serum ferritin (HP:0003281)2.24604617
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.24395363
49Fatigue (HP:0012378)2.22955221
50Male infertility (HP:0003251)2.22772793
51Hypercortisolism (HP:0001578)2.22639405
52Pointed chin (HP:0000307)2.21506321
53Abnormality of the gallbladder (HP:0005264)2.20731591
54Mediastinal lymphadenopathy (HP:0100721)2.19106884
55Abnormality of calcium-phosphate metabolism (HP:0100530)2.17257039
56Acanthocytosis (HP:0001927)2.17249044
57Papillary thyroid carcinoma (HP:0002895)2.17146414
58Mucopolysacchariduria (HP:0008155)2.16188485
59Urinary glycosaminoglycan excretion (HP:0003541)2.16188485
60Peripheral hypomyelination (HP:0007182)2.15804360
61Recurrent fungal infections (HP:0002841)2.15684303
62Abnormality of polysaccharide metabolism (HP:0011012)2.15628526
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15628526
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15628526
65Renal duplication (HP:0000075)2.15477314
66Unilateral renal agenesis (HP:0000122)2.14865817
67Cerebral inclusion bodies (HP:0100314)2.14794158
68Cellulitis (HP:0100658)2.14103131
69Termporal pattern (HP:0011008)2.11989608
70Insidious onset (HP:0003587)2.11989608
71Hypochromic anemia (HP:0001931)2.09022723
72Urticaria (HP:0001025)2.08484654
73Increased IgE level (HP:0003212)2.07955911
74Diaphragmatic weakness (HP:0009113)2.07780575
75Abnormality of endocrine pancreas physiology (HP:0012093)2.06568476
76Abnormality of the pancreatic islet cells (HP:0006476)2.06568476
77Overriding aorta (HP:0002623)2.06536894
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.04870182
79Deep palmar crease (HP:0006191)2.04664092
80Loss of speech (HP:0002371)2.04595098
81Orthostatic hypotension (HP:0001278)2.03383826
82Segmental peripheral demyelination/remyelination (HP:0003481)2.02950198
83Tetraparesis (HP:0002273)2.02881610
84Abnormal hemoglobin (HP:0011902)2.02871482
85Nasal polyposis (HP:0100582)2.01275247
86Ileus (HP:0002595)2.00760471
87Bundle branch block (HP:0011710)2.00341365
88Pustule (HP:0200039)1.99741948
89Supranuclear gaze palsy (HP:0000605)1.99400543
90Paralysis (HP:0003470)1.96856319
91IgA deficiency (HP:0002720)1.96520467
92Broad palm (HP:0001169)1.94246895
93Distal upper limb amyotrophy (HP:0007149)1.94098669
94Upper limb amyotrophy (HP:0009129)1.94098669
95Abnormality of T cells (HP:0002843)1.94095988
96Stomatitis (HP:0010280)1.93870861
97Hypoglycemic seizures (HP:0002173)1.93824187
98Apathy (HP:0000741)1.91905953
99Granulocytopenia (HP:0001913)1.91601130
100Bowel incontinence (HP:0002607)1.91186274
101Abnormal large intestine physiology (HP:0012700)1.90936905
102Colitis (HP:0002583)1.90071115
103Prominent metopic ridge (HP:0005487)1.89920295
104Dysostosis multiplex (HP:0000943)1.89299875
105Meningitis (HP:0001287)1.89147560
106Amyotrophic lateral sclerosis (HP:0007354)1.89113118
107Gastrointestinal infarctions (HP:0005244)1.87528138
108Ankyloglossia (HP:0010296)1.87080520
109Seborrheic dermatitis (HP:0001051)1.86932564
110Abnormality of the thoracic spine (HP:0100711)1.86431283
111Progressive external ophthalmoplegia (HP:0000590)1.85591025
112Vasculitis (HP:0002633)1.85085723
113Genetic anticipation (HP:0003743)1.85013969
114Gastrointestinal inflammation (HP:0004386)1.84873893
115Neuronal loss in central nervous system (HP:0002529)1.84594835
116Diminished motivation (HP:0000745)1.83937883
117Volvulus (HP:0002580)1.83919766
118Hyperbilirubinemia (HP:0002904)1.83725725
119Insulin-resistant diabetes mellitus (HP:0000831)1.83377203
120Heterotopia (HP:0002282)1.83218368
121Abnormality of oral frenula (HP:0000190)1.82564011
122Orchitis (HP:0100796)1.82189982
123Spinal canal stenosis (HP:0003416)1.80955065
124Epistaxis (HP:0000421)1.80737702
125Severe short stature (HP:0003510)1.79696586
126Impaired smooth pursuit (HP:0007772)1.79209448
127Annular pancreas (HP:0001734)1.79080027
128Neurofibrillary tangles (HP:0002185)1.78425958
129Dysmetric saccades (HP:0000641)1.77843042
130Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77717150
131Abnormality of iron homeostasis (HP:0011031)1.77528956
132Neoplasm of the oral cavity (HP:0100649)1.77270903
133Osteomyelitis (HP:0002754)1.76383052
134Basal cell carcinoma (HP:0002671)1.75711601
135Abnormality of T cell physiology (HP:0011840)1.75598726
136Arterial thrombosis (HP:0004420)1.75567269
137Impaired platelet aggregation (HP:0003540)1.75475982
138Abnormal platelet function (HP:0011869)1.75475982
139Long palpebral fissure (HP:0000637)1.75081832
140Pancreatic islet-cell hyperplasia (HP:0004510)1.74916669
141Recurrent skin infections (HP:0001581)1.74320833
142T lymphocytopenia (HP:0005403)1.73857910
143Viral hepatitis (HP:0006562)1.73759503
144Ventricular fibrillation (HP:0001663)1.73676618
145Increased nuchal translucency (HP:0010880)1.73491949
146Decreased circulating renin level (HP:0003351)1.72439413
147Entropion (HP:0000621)1.71832283
148Myocardial infarction (HP:0001658)1.71761802
149Prolonged bleeding time (HP:0003010)1.71662451
150Personality changes (HP:0000751)1.71422704
151Vertebral arch anomaly (HP:0008438)1.70940237
152Myositis (HP:0100614)1.70499451
153Hepatosplenomegaly (HP:0001433)1.70372162
154Renovascular hypertension (HP:0100817)1.69934869
155Thin bony cortex (HP:0002753)1.69313919
156Obsessive-compulsive behavior (HP:0000722)1.69090635
157Depression (HP:0000716)1.67637638
158Hyperparathyroidism (HP:0000843)1.67615302
159Subacute progressive viral hepatitis (HP:0006572)1.67507382
160Decreased motor nerve conduction velocity (HP:0003431)1.67017437
161Vacuolated lymphocytes (HP:0001922)1.66656101
162Thoracic kyphosis (HP:0002942)1.66649739
163Abnormality of the metopic suture (HP:0005556)1.66039510
164Inflammation of the large intestine (HP:0002037)1.65569394
165Sacral dimple (HP:0000960)1.65052873
166Symptomatic seizures (HP:0011145)1.63237749
167Truncal obesity (HP:0001956)1.62370699
168Chest pain (HP:0100749)1.58463848
169Ankle clonus (HP:0011448)1.58219434
170Long toe (HP:0010511)1.56838190
171Bowel diverticulosis (HP:0005222)1.56521432
172Aneurysm (HP:0002617)1.55602749
173Villous atrophy (HP:0011473)1.55348080
174Abnormality of small intestinal villus morphology (HP:0011472)1.55348080
175Hypercalciuria (HP:0002150)1.55233753
176Abnormality of the nasal mucosa (HP:0000433)1.54181274
177Obstructive sleep apnea (HP:0002870)1.53268378
178Abnormality of T cell number (HP:0011839)1.50236905
179Intellectual disability, profound (HP:0002187)1.50045479
180Spinal muscular atrophy (HP:0007269)1.49822266
181Failure to thrive in infancy (HP:0001531)1.48812579
182Adrenal overactivity (HP:0002717)1.48135082
183Tented upper lip vermilion (HP:0010804)1.47992237
184Ureteral stenosis (HP:0000071)1.47583784
185Hemiplegia (HP:0002301)1.47306609
186Myokymia (HP:0002411)1.45998990
187Prominent nose (HP:0000448)1.45988988
188Abnormality of ocular smooth pursuit (HP:0000617)1.45128126
189Frequent falls (HP:0002359)1.44432015
190Glioma (HP:0009733)1.43962510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.94583277
2TRIB33.64993070
3PRKD33.32687550
4EEF2K3.13820633
5IRAK32.95166040
6PKN22.62172216
7TAOK12.61413535
8CDK122.60741901
9PASK2.49553479
10TAOK22.40429309
11MAP2K32.20906894
12ICK2.19062353
13MAP3K142.18272385
14MAP3K92.10807003
15SMG12.09139483
16KSR22.08440402
17RIPK42.07796565
18MAP3K102.07067154
19TYRO31.98260191
20EIF2AK11.97515340
21HIPK21.97318464
22PAK61.90744171
23MAP4K11.88120342
24NME21.83600794
25ALK1.73554631
26SIK21.72737993
27PDGFRA1.63500830
28LATS21.62444516
29ERN11.57544252
30PRKCH1.54303547
31TAOK31.51769894
32MARK21.51085863
33SCYL21.47038316
34TBK11.45653471
35MAP3K31.45004957
36LATS11.43636606
37MATK1.41766161
38RIPK11.39042087
39IRAK41.34778577
40PIM11.29472605
41DMPK1.27538947
42PRKD21.22678863
43NTRK11.21532985
44STK381.19828344
45CAMKK11.17404143
46PTK61.17185674
47MAP3K61.17095489
48CLK11.16786815
49RET1.16739142
50UHMK11.12222994
51TYK21.11679898
52NTRK31.04011906
53IKBKE1.03134077
54MAP3K21.02998437
55FGR1.01524199
56BMPR21.00906152
57MTOR1.00033965
58MAP3K70.97358187
59ZAP700.96719282
60MAP3K80.96440940
61MAP3K10.96440226
62MARK10.95639602
63JAK30.95132079
64BTK0.94123016
65MAP3K50.94063262
66BMX0.92579162
67ITK0.91854373
68MAP3K130.90682780
69NEK20.89597493
70IKBKB0.89006948
71RAF10.85942745
72TTK0.85916422
73CDK60.85010748
74PTK20.84130067
75SIK10.83625747
76NTRK20.83226336
77CDC42BPA0.83206620
78STK100.82779535
79FLT30.81150884
80KSR10.80545523
81SRPK10.78608589
82INSRR0.77742814
83SGK30.77405277
84CDK40.77151027
85CAMK1D0.76863031
86DAPK10.74495279
87TESK10.74332925
88PDGFRB0.74246485
89IRAK20.70185779
90JAK10.69921044
91JAK20.69780608
92SYK0.69255744
93GRK60.68954705
94PAK40.67310081
95MAP3K40.66585394
96MAPKAPK20.63588475
97MOS0.61859980
98TXK0.61795702
99WNK10.61471216
100STK110.60705191
101NEK10.60687788
102SIK30.60449300
103DAPK20.59993413
104STK40.59814343
105DYRK30.59005549
106MAPK150.58702476
107RPS6KA20.58515843
108CHUK0.58302292
109BRD40.58151895
110DDR20.57718745
111PDK10.56806773
112EPHA20.56200388
113PRKAA10.54871627
114CDK70.54598835
115TESK20.52120556
116EPHB10.50900811
117ARAF0.50837653
118PIM20.50724010
119CSK0.48928093
120MAP3K110.48558051
121CDK50.48384876
122RPS6KL10.47416497
123RPS6KC10.47416497
124LMTK20.47202018
125RPS6KA40.46914516
126LYN0.44928379
127IRAK10.44918391
128BLK0.44240773
129MAPK110.43845526
130RPS6KA10.43431140
131MARK30.43069883
132MAPK100.42564561
133MINK10.41768999
134CAMK1G0.41620955
135HCK0.40540021
136CHEK10.40281195
137CHEK20.39523249
138CDK90.39439227
139FGFR30.38191753
140EPHA30.37761320
141TNK20.37755214
142CDK20.37726652
143DYRK1B0.37009359
144FGFR40.35778611
145PAK30.35707300
146LRRK20.34339419
147MAPK80.32890250
148MAPK140.32746656
149PRKD10.32670446
150PDPK10.32507450

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.34727875
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.17956009
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.01717447
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.00706124
5Type II diabetes mellitus_Homo sapiens_hsa049301.96344381
6Other glycan degradation_Homo sapiens_hsa005111.87757472
7mTOR signaling pathway_Homo sapiens_hsa041501.81108392
8Insulin secretion_Homo sapiens_hsa049111.71523414
9Carbohydrate digestion and absorption_Homo sapiens_hsa049731.70895969
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66415381
11Apoptosis_Homo sapiens_hsa042101.62713823
12TNF signaling pathway_Homo sapiens_hsa046681.57256277
13Herpes simplex infection_Homo sapiens_hsa051681.56404804
14Measles_Homo sapiens_hsa051621.55911863
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55440263
16Influenza A_Homo sapiens_hsa051641.49953143
17Hepatitis C_Homo sapiens_hsa051601.45771507
18Chronic myeloid leukemia_Homo sapiens_hsa052201.45693950
19Endometrial cancer_Homo sapiens_hsa052131.44071969
20Leishmaniasis_Homo sapiens_hsa051401.43560543
21Malaria_Homo sapiens_hsa051441.41865202
22Long-term potentiation_Homo sapiens_hsa047201.39735251
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37470452
24VEGF signaling pathway_Homo sapiens_hsa043701.34526542
25Pentose phosphate pathway_Homo sapiens_hsa000301.32780442
26T cell receptor signaling pathway_Homo sapiens_hsa046601.31867875
27Colorectal cancer_Homo sapiens_hsa052101.30703716
28Prolactin signaling pathway_Homo sapiens_hsa049171.29997283
29Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26384322
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.24373133
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24163846
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23962751
33Estrogen signaling pathway_Homo sapiens_hsa049151.22812250
34Glioma_Homo sapiens_hsa052141.22235143
35Viral carcinogenesis_Homo sapiens_hsa052031.21139651
36Dorso-ventral axis formation_Homo sapiens_hsa043201.21049251
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19600471
38Acute myeloid leukemia_Homo sapiens_hsa052211.18473879
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16960492
40Pancreatic cancer_Homo sapiens_hsa052121.16692416
41Tuberculosis_Homo sapiens_hsa051521.16292629
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16176137
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15788303
44Synaptic vesicle cycle_Homo sapiens_hsa047211.14920634
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.14157795
46Epstein-Barr virus infection_Homo sapiens_hsa051691.14077091
47Non-small cell lung cancer_Homo sapiens_hsa052231.13873049
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11630018
49Salmonella infection_Homo sapiens_hsa051321.11248806
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.10746313
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.07495977
52ErbB signaling pathway_Homo sapiens_hsa040121.07216461
53Primary immunodeficiency_Homo sapiens_hsa053401.06813304
54Legionellosis_Homo sapiens_hsa051341.05942527
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05780080
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04330646
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04172289
58Cholinergic synapse_Homo sapiens_hsa047251.03890227
59Dopaminergic synapse_Homo sapiens_hsa047281.03206129
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.03087532
61African trypanosomiasis_Homo sapiens_hsa051431.02293856
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01711609
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00265774
64Hematopoietic cell lineage_Homo sapiens_hsa046400.99800177
65Renal cell carcinoma_Homo sapiens_hsa052110.99467015
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98914781
67Notch signaling pathway_Homo sapiens_hsa043300.98906793
68Cocaine addiction_Homo sapiens_hsa050300.98020820
69Amphetamine addiction_Homo sapiens_hsa050310.97672170
70Choline metabolism in cancer_Homo sapiens_hsa052310.97508135
71Gastric acid secretion_Homo sapiens_hsa049710.96524758
72Cell cycle_Homo sapiens_hsa041100.95158700
73B cell receptor signaling pathway_Homo sapiens_hsa046620.94536984
74Insulin resistance_Homo sapiens_hsa049310.93996930
75Circadian entrainment_Homo sapiens_hsa047130.93854369
76GnRH signaling pathway_Homo sapiens_hsa049120.93203484
77Small cell lung cancer_Homo sapiens_hsa052220.92572760
78Spliceosome_Homo sapiens_hsa030400.92417911
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92383215
80Lysosome_Homo sapiens_hsa041420.92175238
81Chemokine signaling pathway_Homo sapiens_hsa040620.90728638
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.90446496
83Fructose and mannose metabolism_Homo sapiens_hsa000510.90306232
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90243084
85Prion diseases_Homo sapiens_hsa050200.89818535
86Insulin signaling pathway_Homo sapiens_hsa049100.89613148
87Endocytosis_Homo sapiens_hsa041440.89114323
88Oocyte meiosis_Homo sapiens_hsa041140.88191307
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.88111994
90Olfactory transduction_Homo sapiens_hsa047400.87520439
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.86988566
92DNA replication_Homo sapiens_hsa030300.86658793
93HIF-1 signaling pathway_Homo sapiens_hsa040660.85153562
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.84734886
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.83139580
96Pancreatic secretion_Homo sapiens_hsa049720.82991889
97mRNA surveillance pathway_Homo sapiens_hsa030150.82049156
98Circadian rhythm_Homo sapiens_hsa047100.80764090
99MAPK signaling pathway_Homo sapiens_hsa040100.80528836
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.80410793
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80400311
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.78651945
103Type I diabetes mellitus_Homo sapiens_hsa049400.77703714
104Oxytocin signaling pathway_Homo sapiens_hsa049210.77540609
105Thyroid cancer_Homo sapiens_hsa052160.77216361
106Pertussis_Homo sapiens_hsa051330.77176249
107Adherens junction_Homo sapiens_hsa045200.76904443
108Inositol phosphate metabolism_Homo sapiens_hsa005620.76573808
109Glucagon signaling pathway_Homo sapiens_hsa049220.73911446
110Morphine addiction_Homo sapiens_hsa050320.73844185
111Lysine degradation_Homo sapiens_hsa003100.73781990
112Hepatitis B_Homo sapiens_hsa051610.73561825
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73155680
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72907546
115Allograft rejection_Homo sapiens_hsa053300.72771356
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72710436
117p53 signaling pathway_Homo sapiens_hsa041150.72031128
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71841913
119HTLV-I infection_Homo sapiens_hsa051660.71305600
120FoxO signaling pathway_Homo sapiens_hsa040680.70966390
121cAMP signaling pathway_Homo sapiens_hsa040240.70745689
122Autoimmune thyroid disease_Homo sapiens_hsa053200.70617607
123Glutamatergic synapse_Homo sapiens_hsa047240.70341539
124Gap junction_Homo sapiens_hsa045400.69924879
125N-Glycan biosynthesis_Homo sapiens_hsa005100.69440609
126Rheumatoid arthritis_Homo sapiens_hsa053230.68768301
127Bladder cancer_Homo sapiens_hsa052190.68745425
128Osteoclast differentiation_Homo sapiens_hsa043800.68327549
129Antigen processing and presentation_Homo sapiens_hsa046120.68026045
130MicroRNAs in cancer_Homo sapiens_hsa052060.67578008
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67461586
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67181014
133Galactose metabolism_Homo sapiens_hsa000520.67024812
134AMPK signaling pathway_Homo sapiens_hsa041520.66130055
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65722946
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64685509
137GABAergic synapse_Homo sapiens_hsa047270.64124443
138Long-term depression_Homo sapiens_hsa047300.63766692
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62174379
140Platelet activation_Homo sapiens_hsa046110.62003732
141Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61658784
142Prostate cancer_Homo sapiens_hsa052150.61225634
143Viral myocarditis_Homo sapiens_hsa054160.60794767
144Hippo signaling pathway_Homo sapiens_hsa043900.60553227
145Wnt signaling pathway_Homo sapiens_hsa043100.60428217
146Shigellosis_Homo sapiens_hsa051310.60059143
147Rap1 signaling pathway_Homo sapiens_hsa040150.59656166
148Toxoplasmosis_Homo sapiens_hsa051450.59606411
149Graft-versus-host disease_Homo sapiens_hsa053320.59139951
150Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57458201
151Salivary secretion_Homo sapiens_hsa049700.56819345
152Melanogenesis_Homo sapiens_hsa049160.56612387
153Base excision repair_Homo sapiens_hsa034100.56608702
154Thyroid hormone synthesis_Homo sapiens_hsa049180.56351854
155Staphylococcus aureus infection_Homo sapiens_hsa051500.53681045

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