TBC1D23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)6.20489055
2proteasome assembly (GO:0043248)5.18832801
3histone H2A ubiquitination (GO:0033522)4.27420451
4Golgi transport vesicle coating (GO:0048200)4.18751610
5COPI coating of Golgi vesicle (GO:0048205)4.18751610
6ribosome assembly (GO:0042255)4.07049213
7DNA double-strand break processing (GO:0000729)4.02405645
8ER overload response (GO:0006983)3.93864309
9UDP-N-acetylglucosamine metabolic process (GO:0006047)3.84969164
10nuclear pore organization (GO:0006999)3.62496521
11ribonucleoprotein complex disassembly (GO:0032988)3.61798931
12nuclear pore complex assembly (GO:0051292)3.61525461
13positive regulation of mitotic sister chromatid separation (GO:1901970)3.59536790
14positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.59536790
15positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.59536790
16macroautophagy (GO:0016236)3.58349977
17organelle disassembly (GO:1903008)3.56275460
18positive regulation by symbiont of host defense response (GO:0052509)3.46867895
19modulation by symbiont of host defense response (GO:0052031)3.46867895
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.46867895
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.46867895
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.46867895
23modulation by symbiont of host immune response (GO:0052553)3.46867895
24double-strand break repair via nonhomologous end joining (GO:0006303)3.42701160
25non-recombinational repair (GO:0000726)3.42701160
26response to peptidoglycan (GO:0032494)3.40925968
27ether lipid metabolic process (GO:0046485)3.34897458
28kynurenine metabolic process (GO:0070189)3.29739075
29regulation of interferon-beta biosynthetic process (GO:0045357)3.25223964
30growth hormone receptor signaling pathway (GO:0060396)3.22454221
31neutrophil activation involved in immune response (GO:0002283)3.21565976
32neutrophil mediated immunity (GO:0002446)3.18123688
33ER to Golgi vesicle-mediated transport (GO:0006888)3.17890236
34piRNA metabolic process (GO:0034587)3.09888427
35somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.07064605
36isotype switching (GO:0045190)3.07064605
37somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.07064605
38histone mRNA catabolic process (GO:0071044)3.00330117
39interleukin-6-mediated signaling pathway (GO:0070102)2.99114167
40negative regulation of neurotransmitter secretion (GO:0046929)2.97679409
41tryptophan catabolic process (GO:0006569)2.97643564
42indole-containing compound catabolic process (GO:0042436)2.97643564
43indolalkylamine catabolic process (GO:0046218)2.97643564
44positive regulation of protein autophosphorylation (GO:0031954)2.97608040
45maturation of 5.8S rRNA (GO:0000460)2.97526871
46phagosome maturation (GO:0090382)2.94768977
47regulation of transforming growth factor beta2 production (GO:0032909)2.94480045
48synapsis (GO:0007129)2.93706280
49macrophage activation involved in immune response (GO:0002281)2.91174075
50intra-Golgi vesicle-mediated transport (GO:0006891)2.90592974
51regulation of fever generation (GO:0031620)2.89882294
52regulation of type B pancreatic cell apoptotic process (GO:2000674)2.87524877
53attachment of spindle microtubules to kinetochore (GO:0008608)2.86618041
54pore complex assembly (GO:0046931)2.86463411
55positive regulation of cellular amide metabolic process (GO:0034250)2.83719116
56regulation of mitotic spindle checkpoint (GO:1903504)2.82174610
57regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.82174610
58regulation of heat generation (GO:0031650)2.81731293
59glycerol ether metabolic process (GO:0006662)2.80925494
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80084632
61protein K11-linked deubiquitination (GO:0035871)2.79538383
62RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.75923097
63myeloid leukocyte mediated immunity (GO:0002444)2.75290674
64monoubiquitinated protein deubiquitination (GO:0035520)2.75133082
65Rap protein signal transduction (GO:0032486)2.74832087
66tryptophan metabolic process (GO:0006568)2.73550941
67sequestering of metal ion (GO:0051238)2.73221370
68cell adhesion mediated by integrin (GO:0033627)2.72726063
69negative regulation of protein localization to plasma membrane (GO:1903077)2.72463851
70positive regulation of interferon-alpha production (GO:0032727)2.70475718
71cullin deneddylation (GO:0010388)2.70322783
72glycoprotein catabolic process (GO:0006516)2.70045537
73cellular response to growth hormone stimulus (GO:0071378)2.69537587
74vesicle coating (GO:0006901)2.68685584
75protein localization to cell surface (GO:0034394)2.67930628
76nucleotide-sugar biosynthetic process (GO:0009226)2.66754604
77positive regulation of heat generation (GO:0031652)2.63792955
78activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.63604377
79protein K63-linked deubiquitination (GO:0070536)2.62769457
80protein deneddylation (GO:0000338)2.62719473
81positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.61348353
82centriole replication (GO:0007099)2.61339892
83retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60582877
84long-term synaptic potentiation (GO:0060291)2.58879382
85retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57336373
86regulation of prostaglandin secretion (GO:0032306)2.56169317
87signal peptide processing (GO:0006465)2.55055207
88negative regulation of lipid storage (GO:0010888)2.53691189
89regulation of interferon-alpha production (GO:0032647)2.53563418
90lactate metabolic process (GO:0006089)2.52828532
91microglial cell activation (GO:0001774)2.51463159
92multicellular organism reproduction (GO:0032504)2.50925804
93response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.50060376
94response to host immune response (GO:0052572)2.50060376
95neural tube formation (GO:0001841)2.49748925
96glycosphingolipid catabolic process (GO:0046479)2.49570098
97mitochondrial DNA replication (GO:0006264)2.49232363
98response to X-ray (GO:0010165)2.49222111
99ether metabolic process (GO:0018904)2.49055398
100negative regulation of signal transduction by p53 class mediator (GO:1901797)2.48513835
101positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.47169534
102transferrin transport (GO:0033572)2.47035851
103protein targeting to Golgi (GO:0000042)2.46840391
104apoptotic cell clearance (GO:0043277)2.46431998
105rRNA catabolic process (GO:0016075)2.46371027
106ferric iron transport (GO:0015682)2.44849646
107trivalent inorganic cation transport (GO:0072512)2.44849646
108Golgi to endosome transport (GO:0006895)2.43984226
109substrate-dependent cell migration (GO:0006929)2.43870060
110insulin secretion (GO:0030073)2.43447047
111positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.42580746
112protein prenylation (GO:0018342)2.41992506
113prenylation (GO:0097354)2.41992506
114negative regulation of neurotransmitter transport (GO:0051589)2.41050770
115regulation of centriole replication (GO:0046599)2.40305896
116positive regulation of chemokine biosynthetic process (GO:0045080)2.40146600
117protein K48-linked deubiquitination (GO:0071108)2.40030053
118glycolipid catabolic process (GO:0019377)2.39969105
119primitive streak formation (GO:0090009)2.39525905
120regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.39297658
121regulation of protein polyubiquitination (GO:1902914)2.39016572
122neutrophil activation (GO:0042119)2.38582155
123regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.38101009
124establishment of protein localization to Golgi (GO:0072600)2.37830776
125meiotic cell cycle (GO:0051321)2.37585978
126metaphase plate congression (GO:0051310)2.37241982
127negative regulation of mast cell activation (GO:0033004)2.36645311
128regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.36220812
129ganglion development (GO:0061548)2.36048349
130DNA methylation involved in gamete generation (GO:0043046)2.35745008
131vesicle transport along microtubule (GO:0047496)2.34789934
132nucleotide-sugar metabolic process (GO:0009225)2.34525258
133establishment of chromosome localization (GO:0051303)2.34362852
134iron ion transport (GO:0006826)2.34134668
135insulin-like growth factor receptor signaling pathway (GO:0048009)2.32935413
136presynaptic membrane assembly (GO:0097105)2.31786030
137negative regulation of interleukin-17 production (GO:0032700)2.30961622
138neuron cell-cell adhesion (GO:0007158)2.29718086
139germ cell migration (GO:0008354)2.29508391
140regulation of integrin-mediated signaling pathway (GO:2001044)2.29208382
141regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.29073412
142granulocyte activation (GO:0036230)2.28807380
143positive regulation of chromosome segregation (GO:0051984)2.28187368
144positive regulation of histone H3-K4 methylation (GO:0051571)2.28016099
145nerve growth factor signaling pathway (GO:0038180)2.27438011
146protein neddylation (GO:0045116)2.27254717
147negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.26895826
148locomotory exploration behavior (GO:0035641)2.26772200
149keratan sulfate catabolic process (GO:0042340)2.26571667
150inner ear receptor cell development (GO:0060119)2.26245476
151regulation of acyl-CoA biosynthetic process (GO:0050812)2.26238801
152negative regulation of exocytosis (GO:0045920)2.25283978
153iron ion import (GO:0097286)2.24639707
154positive regulation of vesicle fusion (GO:0031340)2.24398551
155COPII vesicle coating (GO:0048208)2.24328984
156regulation of protein autophosphorylation (GO:0031952)2.24118475
157regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.23903277
158regulation of fibroblast apoptotic process (GO:2000269)2.23423048
159positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.23093893
160somatic recombination of immunoglobulin gene segments (GO:0016447)2.23039490
161type B pancreatic cell development (GO:0003323)2.22842089
162negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.22759995
163fibroblast migration (GO:0010761)2.22516443
164early endosome to late endosome transport (GO:0045022)2.22468693
165hydrogen peroxide biosynthetic process (GO:0050665)2.22336962
166lipid particle organization (GO:0034389)2.21785193
167positive regulation of meiotic cell cycle (GO:0051446)2.20554238
168regulation of histone H3-K9 methylation (GO:0051570)2.20317393
169sequestering of extracellular ligand from receptor (GO:0035581)2.19737555
170regulation of DNA methylation (GO:0044030)2.19625163
171blastocyst development (GO:0001824)2.19152858
172myelin assembly (GO:0032288)2.19078839
173regulation of establishment of cell polarity (GO:2000114)2.19017029
174regulation of metalloenzyme activity (GO:0048552)2.18915447
175somite rostral/caudal axis specification (GO:0032525)2.18906128
176positive regulation of meiosis (GO:0045836)2.18868005
177response to host (GO:0075136)2.18763060
178response to host defenses (GO:0052200)2.18763060
179response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.18763060
180positive regulation of macrophage cytokine production (GO:0060907)2.17896638
181macrophage activation (GO:0042116)2.17872210
182mitotic metaphase plate congression (GO:0007080)2.16169306
183histone H2A monoubiquitination (GO:0035518)2.15673479
184chondroitin sulfate catabolic process (GO:0030207)2.15113528
185lipopolysaccharide-mediated signaling pathway (GO:0031663)2.14479944
186regulation of synaptic vesicle exocytosis (GO:2000300)2.14391231
187ceramide catabolic process (GO:0046514)2.13822194
188positive regulation of macroautophagy (GO:0016239)2.12394467
189activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.12309578
190maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.11681285
191chondrocyte development (GO:0002063)2.11556891

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD_19615063_ChIP-ChIP_OVARY_Human3.69464018
2* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.96032026
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.91291117
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.61867729
5ELK1_19687146_ChIP-ChIP_HELA_Human2.45029448
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.41478430
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.36310613
8GBX2_23144817_ChIP-Seq_PC3_Human2.29272492
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.28556193
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.28479332
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24935852
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.23447322
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15383985
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11649002
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06491581
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00590104
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.98015261
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97669282
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.94833366
20TAF15_26573619_Chip-Seq_HEK293_Human1.92534847
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89677928
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.87444425
23* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.84978792
24* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.84978792
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.82845767
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.82097489
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79070493
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.75287317
29* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73332425
30* IRF8_27001747_Chip-Seq_BMDM_Mouse1.72601405
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66872879
32SMAD4_21799915_ChIP-Seq_A2780_Human1.66790502
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.66047166
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62116316
35TP53_16413492_ChIP-PET_HCT116_Human1.61752083
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61299921
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60554527
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59175888
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.58461233
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53746846
41VDR_22108803_ChIP-Seq_LS180_Human1.52644918
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.51625719
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49781313
44CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.49656579
45ZNF274_21170338_ChIP-Seq_K562_Hela1.47096919
46P300_19829295_ChIP-Seq_ESCs_Human1.47001934
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46674613
48* CJUN_26792858_Chip-Seq_BT549_Human1.46342119
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45896742
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45128255
51CDX2_22108803_ChIP-Seq_LS180_Human1.45090363
52STAT3_23295773_ChIP-Seq_U87_Human1.44502973
53ER_23166858_ChIP-Seq_MCF-7_Human1.43734130
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43400276
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42908985
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.42302630
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.42007639
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.41925364
59VDR_24787735_ChIP-Seq_THP-1_Human1.41923510
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.40652035
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40590574
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.39753951
63* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.39532352
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38766271
65BRD4_25478319_ChIP-Seq_HGPS_Human1.38525258
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38352346
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37670568
68FUS_26573619_Chip-Seq_HEK293_Human1.37580846
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.37016839
70VDR_23849224_ChIP-Seq_CD4+_Human1.36376141
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35220919
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.34511719
73CRX_20693478_ChIP-Seq_RETINA_Mouse1.31383311
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30111037
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28920065
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28912697
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.28175911
78SALL4_22934838_ChIP-ChIP_CD34+_Human1.28023582
79IGF1R_20145208_ChIP-Seq_DFB_Human1.27636327
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.23679975
81TCF4_18268006_ChIP-ChIP_LS174T_Human1.23405844
82RXR_22108803_ChIP-Seq_LS180_Human1.23198641
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.22889664
84STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22011002
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21143118
86BCAT_22108803_ChIP-Seq_LS180_Human1.20074046
87GATA1_22025678_ChIP-Seq_K562_Human1.19830979
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.18910508
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18822873
90AR_25329375_ChIP-Seq_VCAP_Human1.17311054
91PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16273477
92AHR_22903824_ChIP-Seq_MCF-7_Human1.14183986
93SOX2_20726797_ChIP-Seq_SW620_Human1.13930602
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13096215
95* TCF4_23295773_ChIP-Seq_U87_Human1.12689526
96* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12457743
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12410982
98EWS_26573619_Chip-Seq_HEK293_Human1.12083445
99NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10360969
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09998150
101NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09981918
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.09351314
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08955161
104GATA2_21666600_ChIP-Seq_HMVEC_Human1.08742823
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07934520
106CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07914078
107FLI1_27457419_Chip-Seq_LIVER_Mouse1.06568696
108TCF4_22108803_ChIP-Seq_LS180_Human1.06210872
109TP53_18474530_ChIP-ChIP_U2OS_Human1.06197562
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05839340
111P300_18555785_Chip-Seq_ESCs_Mouse1.05559813
112TP63_23658742_ChIP-Seq_EP156T_Human1.05223785
113E2F1_18555785_Chip-Seq_ESCs_Mouse1.05209984
114TFEB_21752829_ChIP-Seq_HELA_Human1.04631825
115P53_22387025_ChIP-Seq_ESCs_Mouse1.04410202
116CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03499282
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.03144263
118CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03037091
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02939127
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02604035
121SMAD3_21741376_ChIP-Seq_ESCs_Human1.01907817
122AR_21909140_ChIP-Seq_LNCAP_Human1.01173749
123OCT4_18555785_Chip-Seq_ESCs_Mouse1.00704286
124SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99908791
125CMYC_18555785_Chip-Seq_ESCs_Mouse0.99177269
126EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99136604
127SOX2_19829295_ChIP-Seq_ESCs_Human0.98798957
128NANOG_19829295_ChIP-Seq_ESCs_Human0.98798957
129FLI1_21867929_ChIP-Seq_TH2_Mouse0.98530118
130HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98286868
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.97787467
132* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97201378
133SOX2_18555785_Chip-Seq_ESCs_Mouse0.96933066
134YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95469953
135TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95287563
136HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95201858
137* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94872857
138* CBP_20019798_ChIP-Seq_JUKART_Human0.94872857
139RUNX2_22187159_ChIP-Seq_PCA_Human0.94489024
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93637683
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93485239
142SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93422339
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92496606
144AR_21572438_ChIP-Seq_LNCaP_Human0.91963548
145FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91930337
146LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91715114
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91425547

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.32864709
2MP0003950_abnormal_plasma_membrane4.97601070
3MP0003172_abnormal_lysosome_physiology3.67062063
4MP0006054_spinal_hemorrhage3.62837872
5MP0003718_maternal_effect3.31507411
6MP0003283_abnormal_digestive_organ3.18595135
7MP0008438_abnormal_cutaneous_collagen3.15318217
8MP0003183_abnormal_peptide_metabolism2.99303791
9MP0002877_abnormal_melanocyte_morpholog2.90940550
10MP0009780_abnormal_chondrocyte_physiolo2.76367703
11MP0005257_abnormal_intraocular_pressure2.73820874
12MP0003656_abnormal_erythrocyte_physiolo2.67477224
13MP0004147_increased_porphyrin_level2.63569272
14MP0002638_abnormal_pupillary_reflex2.62078872
15MP0005171_absent_coat_pigmentation2.53060411
16MP0005058_abnormal_lysosome_morphology2.50722529
17MP0010386_abnormal_urinary_bladder2.37914939
18MP0008057_abnormal_DNA_replication2.33387558
19MP0008058_abnormal_DNA_repair2.17743350
20MP0005275_abnormal_skin_tensile2.16190467
21MP0003252_abnormal_bile_duct2.14464207
22MP0005085_abnormal_gallbladder_physiolo2.10046938
23MP0005076_abnormal_cell_differentiation2.05405279
24MP0009697_abnormal_copulation2.04059263
25MP0003303_peritoneal_inflammation1.92443360
26MP0003566_abnormal_cell_adhesion1.88298767
27MP0001188_hyperpigmentation1.85442732
28MP0004957_abnormal_blastocyst_morpholog1.85352220
29MP0003191_abnormal_cellular_cholesterol1.82723412
30MP0000013_abnormal_adipose_tissue1.81936670
31MP0010678_abnormal_skin_adnexa1.81650452
32MP0000427_abnormal_hair_cycle1.78715523
33MP0002909_abnormal_adrenal_gland1.77418460
34MP0003941_abnormal_skin_development1.75865200
35MP0003091_abnormal_cell_migration1.73061240
36MP0005503_abnormal_tendon_morphology1.72843433
37MP0003436_decreased_susceptibility_to1.69849678
38MP0002419_abnormal_innate_immunity1.65413808
39MP0004858_abnormal_nervous_system1.63254370
40MP0001533_abnormal_skeleton_physiology1.62201768
41MP0004134_abnormal_chest_morphology1.61638216
42MP0005310_abnormal_salivary_gland1.57977388
43MP0003705_abnormal_hypodermis_morpholog1.55024924
44MP0006082_CNS_inflammation1.51980246
45MP0009278_abnormal_bone_marrow1.51344531
46MP0002693_abnormal_pancreas_physiology1.51195090
47MP0008877_abnormal_DNA_methylation1.50687356
48MP0008875_abnormal_xenobiotic_pharmacok1.47920997
49MP0005084_abnormal_gallbladder_morpholo1.47892212
50MP0003186_abnormal_redox_activity1.47217918
51MP0005395_other_phenotype1.42391197
52MP0000015_abnormal_ear_pigmentation1.41401149
53MP0002998_abnormal_bone_remodeling1.40397236
54MP0003300_gastrointestinal_ulcer1.37667260
55MP0001324_abnormal_eye_pigmentation1.36435237
56MP0008007_abnormal_cellular_replicative1.36001644
57MP0000647_abnormal_sebaceous_gland1.35248421
58MP0001501_abnormal_sleep_pattern1.34466982
59MP0010368_abnormal_lymphatic_system1.30915705
60MP0005164_abnormal_response_to1.29676168
61MP0003634_abnormal_glial_cell1.27920283
62MP0003690_abnormal_glial_cell1.26618554
63MP0008775_abnormal_heart_ventricle1.26068490
64MP0005174_abnormal_tail_pigmentation1.25041161
65MP0001666_abnormal_nutrient_absorption1.24017962
66MP0001835_abnormal_antigen_presentation1.21454697
67MP0000383_abnormal_hair_follicle1.20550400
68MP0005408_hypopigmentation1.19732321
69MP0010094_abnormal_chromosome_stability1.19516014
70MP0005360_urolithiasis1.19034692
71MP0005390_skeleton_phenotype1.17950502
72MP0002138_abnormal_hepatobiliary_system1.17107080
73MP0000371_diluted_coat_color1.16957867
74MP0006072_abnormal_retinal_apoptosis1.14540269
75MP0002102_abnormal_ear_morphology1.14284946
76MP0002254_reproductive_system_inflammat1.14215507
77MP0002139_abnormal_hepatobiliary_system1.13528414
78MP0004272_abnormal_basement_membrane1.11777643
79MP0003221_abnormal_cardiomyocyte_apopto1.11035601
80MP0003890_abnormal_embryonic-extraembry1.10487877
81MP0004510_myositis1.09995981
82MP0005187_abnormal_penis_morphology1.09924125
83MP0010234_abnormal_vibrissa_follicle1.09713776
84MP0008932_abnormal_embryonic_tissue1.09712468
85MP0004130_abnormal_muscle_cell1.09164444
86MP0005197_abnormal_uvea_morphology1.08862654
87MP0001299_abnormal_eye_distance/1.06915140
88MP0003868_abnormal_feces_composition1.05516765
89MP0005367_renal/urinary_system_phenotyp1.05336189
90MP0000516_abnormal_urinary_system1.05336189
91MP0002896_abnormal_bone_mineralization1.05078688
92MP0004947_skin_inflammation1.02932597
93MP0001542_abnormal_bone_strength1.01933800
94MP0002060_abnormal_skin_morphology1.01505150
95MP0003279_aneurysm1.00348796
96MP0001944_abnormal_pancreas_morphology1.00168507
97MP0005023_abnormal_wound_healing0.99650804
98MP0005000_abnormal_immune_tolerance0.99284822
99MP0003045_fibrosis0.99038833
100MP0002876_abnormal_thyroid_physiology0.97688197
101MP0001929_abnormal_gametogenesis0.96178360
102MP0005365_abnormal_bile_salt0.95087449
103MP0003077_abnormal_cell_cycle0.94914647
104MP0000358_abnormal_cell_content/0.93778476
105MP0000920_abnormal_myelination0.93266143
106MP0003448_altered_tumor_morphology0.90223609
107MP0005410_abnormal_fertilization0.89368688
108MP0001661_extended_life_span0.89085706
109MP0002332_abnormal_exercise_endurance0.87454789
110MP0002168_other_aberrant_phenotype0.87309004
111MP0004215_abnormal_myocardial_fiber0.86876222
112MP0002084_abnormal_developmental_patter0.86712881
113MP0001191_abnormal_skin_condition0.86610213
114MP0002928_abnormal_bile_duct0.86127390
115MP0008260_abnormal_autophagy0.86010604
116MP0003795_abnormal_bone_structure0.85991749
117MP0004883_abnormal_blood_vessel0.85806300
118MP0003693_abnormal_embryo_hatching0.85796779
119MP0001186_pigmentation_phenotype0.85644476
120MP0004264_abnormal_extraembryonic_tissu0.85483091
121MP0005508_abnormal_skeleton_morphology0.85398943
122MP0003195_calcinosis0.85131634
123MP0002090_abnormal_vision0.85031213
124MP0001730_embryonic_growth_arrest0.82353435
125MP0001958_emphysema0.82244281
126MP0010307_abnormal_tumor_latency0.81479051
127MP0005319_abnormal_enzyme/_coenzyme0.80680600
128MP0005645_abnormal_hypothalamus_physiol0.79453795
129MP0002452_abnormal_antigen_presenting0.79352745
130MP0009785_altered_susceptibility_to0.78682396
131MP0003699_abnormal_female_reproductive0.78101719
132MP0000343_altered_response_to0.77866368
133MP0001243_abnormal_dermal_layer0.77671763
134MP0001879_abnormal_lymphatic_vessel0.77651607
135MP0002086_abnormal_extraembryonic_tissu0.76893310
136MP0004859_abnormal_synaptic_plasticity0.76294410
137MP0000733_abnormal_muscle_development0.76267769
138MP0005332_abnormal_amino_acid0.76010511
139MP0000653_abnormal_sex_gland0.75507158
140MP0002063_abnormal_learning/memory/cond0.75492774
141MP0004270_analgesia0.74574196
142MP0008789_abnormal_olfactory_epithelium0.74471848
143MP0002148_abnormal_hypersensitivity_rea0.74360141
144MP0002108_abnormal_muscle_morphology0.74332368
145MP0000372_irregular_coat_pigmentation0.74165626
146MP0002295_abnormal_pulmonary_circulatio0.73647368
147MP0003635_abnormal_synaptic_transmissio0.73508078
148MP0001697_abnormal_embryo_size0.71914259
149MP0008004_abnormal_stomach_pH0.71337282
150MP0010329_abnormal_lipoprotein_level0.71213201
151MP0005464_abnormal_platelet_physiology0.70426947
152MP0001915_intracranial_hemorrhage0.70070506
153MP0003724_increased_susceptibility_to0.69277686
154MP0009840_abnormal_foam_cell0.69089006
155MP0010352_gastrointestinal_tract_polyps0.68952185
156MP0004043_abnormal_pH_regulation0.68935573
157MP0002115_abnormal_skeleton_extremities0.68414234
158MP0003786_premature_aging0.67837616
159MP0004084_abnormal_cardiac_muscle0.67712916
160MP0005535_abnormal_body_temperature0.67662552
161MP0003075_altered_response_to0.67086343
162MP0001119_abnormal_female_reproductive0.66367332
163MP0003937_abnormal_limbs/digits/tail_de0.66204818
164MP0005647_abnormal_sex_gland0.65226689
165MP0005376_homeostasis/metabolism_phenot0.65036547
166MP0005621_abnormal_cell_physiology0.64965898
167MP0000538_abnormal_urinary_bladder0.64065376
168MP0001764_abnormal_homeostasis0.64009108
169MP0003828_pulmonary_edema0.63662894
170MP0001849_ear_inflammation0.63607073
171MP0005167_abnormal_blood-brain_barrier0.63552693
172MP0005384_cellular_phenotype0.63266738
173MP0004185_abnormal_adipocyte_glucose0.62592592
174MP0002837_dystrophic_cardiac_calcinosis0.61814058
175MP0002078_abnormal_glucose_homeostasis0.59806184
176MP0005253_abnormal_eye_physiology0.58726343
177MP0000465_gastrointestinal_hemorrhage0.58690299

Predicted human phenotypes

RankGene SetZ-score
1Posterior subcapsular cataract (HP:0007787)4.55876660
2Tetraparesis (HP:0002273)4.17217576
3Increased cerebral lipofuscin (HP:0011813)4.14269092
4Increased neuronal autofluorescent lipopigment (HP:0002074)3.97612662
5Recurrent abscess formation (HP:0002722)3.52935930
6Recurrent bacterial skin infections (HP:0005406)3.32830789
7Methylmalonic acidemia (HP:0002912)3.30014867
8Eczematoid dermatitis (HP:0000976)3.24444686
9Epiphyseal dysplasia (HP:0002656)3.14967286
10Absent eyebrow (HP:0002223)3.01092476
11Submucous cleft hard palate (HP:0000176)2.99078254
12Volvulus (HP:0002580)2.89524948
13Metaphyseal dysplasia (HP:0100255)2.89302653
14Subcapsular cataract (HP:0000523)2.87716060
15Fair hair (HP:0002286)2.86649966
16Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.86539730
17Abnormality of the vitamin B12 metabolism (HP:0004341)2.84546722
18Follicular hyperkeratosis (HP:0007502)2.76446410
19Intrahepatic cholestasis (HP:0001406)2.73867239
20Persistence of primary teeth (HP:0006335)2.69310943
21Supernumerary spleens (HP:0009799)2.68872259
22Dysostosis multiplex (HP:0000943)2.67408437
23Progressive visual loss (HP:0000529)2.66129527
24Urinary glycosaminoglycan excretion (HP:0003541)2.62669089
25Mucopolysacchariduria (HP:0008155)2.62669089
26Thyroid carcinoma (HP:0002890)2.62641674
27Small epiphyses (HP:0010585)2.60360816
28Abnormality of methionine metabolism (HP:0010901)2.59395125
29Gingivitis (HP:0000230)2.56548276
30Abnormality of vitamin B metabolism (HP:0004340)2.55920478
31Biliary tract neoplasm (HP:0100574)2.54916880
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.52191974
33Abnormality of polysaccharide metabolism (HP:0011012)2.52191974
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.52191974
35Short middle phalanx of the 5th finger (HP:0004220)2.51035338
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49103791
37Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.48558105
38Hematochezia (HP:0002573)2.47941848
39Aplasia/Hypoplasia of the tibia (HP:0005772)2.47512146
40Hypoplasia of the odontoid process (HP:0003311)2.47497857
41Hypoplastic ischia (HP:0003175)2.47493514
42Disinhibition (HP:0000734)2.43613217
43Cervical subluxation (HP:0003308)2.42117134
44Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.40458034
45Steatorrhea (HP:0002570)2.38921240
46Short tibia (HP:0005736)2.38487200
47Macroorchidism (HP:0000053)2.38467323
48Global brain atrophy (HP:0002283)2.38258883
49Neoplasm of the peripheral nervous system (HP:0100007)2.37779626
50Abnormality of the odontoid process (HP:0003310)2.37111511
51Coarse hair (HP:0002208)2.34666113
52Type I transferrin isoform profile (HP:0003642)2.34623868
53Abnormal protein glycosylation (HP:0012346)2.33108959
54Abnormal glycosylation (HP:0012345)2.33108959
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33108959
56Abnormal protein N-linked glycosylation (HP:0012347)2.33108959
57Gonadotropin excess (HP:0000837)2.31580638
58Recurrent gram-negative bacterial infections (HP:0005420)2.30834543
59Abnormality of glycolipid metabolism (HP:0010969)2.29345197
60Abnormality of liposaccharide metabolism (HP:0010968)2.29345197
61Abnormality of glycosphingolipid metabolism (HP:0004343)2.29345197
62Abnormality of the ischium (HP:0003174)2.28799487
63Abnormal spermatogenesis (HP:0008669)2.28187051
64Osteolytic defects of the hand bones (HP:0009699)2.21721425
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.21721425
66Akinesia (HP:0002304)2.20875386
67Thick nail (HP:0001805)2.20199256
68Abnormality of proline metabolism (HP:0010907)2.20105938
69Hydroxyprolinuria (HP:0003080)2.20105938
70Hypoplasia of the uterus (HP:0000013)2.19912329
71Fat malabsorption (HP:0002630)2.18903802
72Absent frontal sinuses (HP:0002688)2.18646213
73Insulin-resistant diabetes mellitus (HP:0000831)2.18420728
74Protruding tongue (HP:0010808)2.17520290
75Menstrual irregularities (HP:0000858)2.16318171
76Vertebral compression fractures (HP:0002953)2.14409601
77Inappropriate behavior (HP:0000719)2.13593622
78Palpitations (HP:0001962)2.12554763
79Poikilocytosis (HP:0004447)2.12487976
80Abnormality of the frontal sinuses (HP:0002687)2.12062415
81Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.11735770
82Irregular vertebral endplates (HP:0003301)2.11158553
83Mild short stature (HP:0003502)2.10126399
84Microglossia (HP:0000171)2.09724466
85Aplasia/Hypoplasia of the tongue (HP:0010295)2.09304317
86Renal cortical cysts (HP:0000803)2.08416396
87Metaphyseal cupping (HP:0003021)2.07582623
88Disproportionate short-trunk short stature (HP:0003521)2.06109522
89Segmental peripheral demyelination/remyelination (HP:0003481)2.05632515
90Premature rupture of membranes (HP:0001788)2.05133140
91Reduced antithrombin III activity (HP:0001976)2.02984006
92Facial diplegia (HP:0001349)2.02138318
93Progressive sensorineural hearing impairment (HP:0000408)2.02001691
94Abnormal auditory evoked potentials (HP:0006958)2.01643517
95Ascites (HP:0001541)2.00902756
96Stomatitis (HP:0010280)2.00305800
97Methylmalonic aciduria (HP:0012120)1.99937848
98Increased mean platelet volume (HP:0011877)1.99721578
99Absent eyelashes (HP:0000561)1.99620976
100Neoplasm of the rectum (HP:0100743)1.99341409
101Abnormality of the pons (HP:0007361)1.99179110
102Cortical dysplasia (HP:0002539)1.98849392
103Stillbirth (HP:0003826)1.98281862
104Lower limb hyperreflexia (HP:0002395)1.98055453
105Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.97636858
106Abnormality of the phalanges of the 5th finger (HP:0004213)1.97389828
107Neoplasm of the small intestine (HP:0100833)1.96643228
108Resting tremor (HP:0002322)1.96411526
109Abnormality of the musculature of the pelvis (HP:0001469)1.94897966
110Abnormality of the hip-girdle musculature (HP:0001445)1.94897966
111Abnormality of macrophages (HP:0004311)1.94801050
112Ketoacidosis (HP:0001993)1.93212415
113Curly hair (HP:0002212)1.91936321
114Proximal tubulopathy (HP:0000114)1.91344260
115Protuberant abdomen (HP:0001538)1.90682523
116Acanthocytosis (HP:0001927)1.90572061
117Abnormal pancreas size (HP:0012094)1.89823650
118Abnormality of the vertebral endplates (HP:0005106)1.88993283
119Abnormal biliary tract morphology (HP:0012440)1.88764214
120Abnormality of the heme biosynthetic pathway (HP:0010472)1.88702543
121Papillary thyroid carcinoma (HP:0002895)1.88502130
122Hypoproteinemia (HP:0003075)1.88226881
123Hyperinsulinemic hypoglycemia (HP:0000825)1.87889656
124Shoulder girdle muscle weakness (HP:0003547)1.87392656
125Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87111215
126Open mouth (HP:0000194)1.86581648
127Azoospermia (HP:0000027)1.86408404
128Flattened epiphyses (HP:0003071)1.86155922
129Generalized hypopigmentation of hair (HP:0011358)1.85675070
130Glucose intolerance (HP:0000833)1.85362883
131Increased CSF protein (HP:0002922)1.84978077
132Upper limb muscle weakness (HP:0003484)1.84714865
133Blue irides (HP:0000635)1.84305350
134Drooling (HP:0002307)1.83834937
135Excessive salivation (HP:0003781)1.83834937
136Abnormality of vitamin metabolism (HP:0100508)1.83320295
137Aortic dissection (HP:0002647)1.81915920
138Cholecystitis (HP:0001082)1.81752764
139Abnormal gallbladder physiology (HP:0012438)1.81752764
140Hyperglycemia (HP:0003074)1.79918533
141Ankle contracture (HP:0006466)1.78873958
142Hypoplasia of the pons (HP:0012110)1.78649024
143Hypokinesia (HP:0002375)1.78052833
144Severe short stature (HP:0003510)1.77170522
145Ependymoma (HP:0002888)1.75849951
146Hypophosphatemic rickets (HP:0004912)1.74554977
147Horizontal nystagmus (HP:0000666)1.73972162
148Mediastinal lymphadenopathy (HP:0100721)1.72577066
149Abnormality of chromosome stability (HP:0003220)1.72280708
150Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.71533962
151Cupped ribs (HP:0000887)1.69951802
152Tubulointerstitial nephritis (HP:0001970)1.69660276
153Aortic aneurysm (HP:0004942)1.69165777
154Chromsome breakage (HP:0040012)1.68711799
155Hypoplasia of the fovea (HP:0007750)1.68572411
156Aplasia/Hypoplasia of the fovea (HP:0008060)1.68572411
157Degeneration of anterior horn cells (HP:0002398)1.68563858
158Abnormality of the anterior horn cell (HP:0006802)1.68563858
159Entropion (HP:0000621)1.68382297
160Atonic seizures (HP:0010819)1.67662609
161Patchy hypopigmentation of hair (HP:0011365)1.66865840
162Abnormal foot bone ossification (HP:0010675)1.66783079
163Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66766311
164Acute myeloid leukemia (HP:0004808)1.66712260
165Meningioma (HP:0002858)1.66493614
166Widely spaced teeth (HP:0000687)1.66479644
167Thyroid-stimulating hormone excess (HP:0002925)1.66428064
168Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65724811
169Thoracolumbar scoliosis (HP:0002944)1.65507400
170Aplasia/hypoplasia of the uterus (HP:0008684)1.65449566
171Termporal pattern (HP:0011008)1.65419682
172Insidious onset (HP:0003587)1.65419682
173Spondylolisthesis (HP:0003302)1.65020624
174Gait imbalance (HP:0002141)1.64291749
175Relative macrocephaly (HP:0004482)1.62355899
176Biconcave vertebral bodies (HP:0004586)1.62064637
177Deep palmar crease (HP:0006191)1.61752163
178Abnormality of dentin (HP:0010299)1.60778490
179Action tremor (HP:0002345)1.59850194
180Short nail (HP:0001799)1.59710457
181Pectus carinatum (HP:0000768)1.59491328
182Congenital primary aphakia (HP:0007707)1.56823300
183Dilatation of the ascending aorta (HP:0005111)1.56637216
184Wormian bones (HP:0002645)1.56541092
185Cystic hygroma (HP:0000476)1.53907799
186Spinal muscular atrophy (HP:0007269)1.53654973
187Cubitus valgus (HP:0002967)1.53216910
188Interstitial pulmonary disease (HP:0006530)1.52942479
189Hypoplastic labia majora (HP:0000059)1.52014066
190Mitral stenosis (HP:0001718)1.51058703
191Apathy (HP:0000741)1.48252155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT35.57946273
2EIF2AK13.93122796
3RIPK43.49039749
4MST43.17275417
5ACVR1B3.01482032
6ERBB32.97717485
7FRK2.67437628
8NEK12.46467660
9TAOK32.37101806
10NEK92.33471192
11SGK22.23539809
12MAP3K22.17087428
13CASK2.11637653
14TRIM282.01384669
15EIF2AK31.97658625
16IRAK41.95726006
17INSRR1.94300430
18SRPK11.86543860
19EPHA31.84251294
20MAP3K121.83639504
21IRAK31.81062227
22CAMKK21.78970243
23PRKD31.72201450
24MAP3K141.65936644
25PLK31.62456105
26SGK31.59718743
27SGK2231.55752222
28SGK4941.55752222
29EPHB11.55115809
30SCYL21.52813732
31PLK21.48500133
32IRAK11.36872492
33TSSK61.36705741
34MARK31.33739808
35ERBB41.33211684
36MYLK1.27583672
37MKNK21.27475837
38TYK21.26884221
39BCR1.20329844
40TTK1.18898752
41TGFBR21.18346167
42NTRK31.16170944
43TNIK1.15529764
44TBK11.14290780
45PRKCH1.13219040
46MAPK131.12824567
47KSR11.11866381
48MAP3K41.11551008
49FLT31.10036624
50STK38L1.09306166
51TYRO31.08824557
52TRPM71.08179770
53PDGFRB1.06835364
54NEK61.06418365
55MAPK151.05963321
56JAK11.05431456
57CSF1R1.04378169
58PDGFRA1.03690488
59BMPR1B1.03174930
60BMPR21.02964803
61BRSK21.02293543
62EIF2AK20.97972485
63NUAK10.97255143
64JAK30.96991316
65STK30.94700613
66DDR20.93711640
67FGFR30.92088971
68STK390.90740173
69EPHA40.89886631
70MARK10.89805383
71MKNK10.88993903
72PIK3CG0.88421188
73CSK0.88338822
74CAMK1D0.85647103
75SGK10.85465156
76YES10.85246823
77WNK30.84837807
78PLK40.81600156
79TGFBR10.81360717
80NTRK20.81245439
81BUB10.80902982
82TTN0.80663154
83BRAF0.80417756
84STK160.79397415
85PRKCE0.78864113
86CHUK0.78317847
87OXSR10.77229120
88PASK0.76746032
89MST1R0.75823855
90FES0.74800647
91FGR0.73930951
92PAK30.72680420
93WEE10.71088276
94RAF10.71045116
95BRD40.68668902
96TEC0.67538331
97LATS10.66285701
98PTK2B0.64840281
99RPS6KA20.64733486
100GSK3A0.64165598
101PLK10.63118621
102NEK20.63074989
103MAP2K10.62525856
104PDK20.62120533
105IRAK20.60941252
106HIPK20.60735584
107PBK0.60479162
108ERN10.60313481
109CCNB10.60281911
110MAP2K40.58548592
111FER0.58316928
112BMX0.57739885
113PTK20.56892210
114PAK20.56020085
115RET0.55647801
116PIM10.54575404
117ZAK0.54567526
118HCK0.53085798
119PHKG20.52125725
120PHKG10.52125725
121MET0.51317386
122PDK30.51202030
123PDK40.51202030
124KSR20.51189180
125CLK10.47519783
126IKBKE0.46669071
127TIE10.45672155
128PIK3CA0.45215016
129SIK30.45014610
130VRK10.44900245
131ADRBK20.44529427
132MAP3K50.44340667
133IGF1R0.43318001
134ATM0.43117508
135MAP2K30.42417706
136STK240.41804361
137STK100.41720651
138BRSK10.41461498
139NTRK10.41161436
140PRKG20.40540546
141CDK90.39993469
142EGFR0.39969332
143GRK70.39729538
144PTK60.39419652
145DMPK0.39413420
146MUSK0.39412814
147IKBKB0.38436719
148CAMK1G0.38272685
149PRKACB0.37414210
150CDK60.36897030
151PKN20.36260658
152INSR0.36235379
153OBSCN0.36067610
154MAPK70.35835270
155CAMKK10.35609123
156RPS6KB10.35538058
157MOS0.34787515
158ABL10.33056801
159FGFR10.31824804
160MAP4K20.29222552
161GRK10.28272418
162RPS6KA40.28029921

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002326.45836704
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.74947774
3Basal transcription factors_Homo sapiens_hsa030222.49173522
4Proteasome_Homo sapiens_hsa030502.46810089
5Non-homologous end-joining_Homo sapiens_hsa034502.31328866
6Propanoate metabolism_Homo sapiens_hsa006402.04517102
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.04470325
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.03716018
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01718651
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.97431975
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84833605
12Steroid biosynthesis_Homo sapiens_hsa001001.80356719
13Collecting duct acid secretion_Homo sapiens_hsa049661.78238909
14Phagosome_Homo sapiens_hsa041451.72613136
15Rheumatoid arthritis_Homo sapiens_hsa053231.72530138
16Type II diabetes mellitus_Homo sapiens_hsa049301.72484537
17Lysosome_Homo sapiens_hsa041421.67121120
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63879607
19RNA degradation_Homo sapiens_hsa030181.63687486
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63458163
21Selenocompound metabolism_Homo sapiens_hsa004501.59995540
22Vibrio cholerae infection_Homo sapiens_hsa051101.58731467
23Fatty acid elongation_Homo sapiens_hsa000621.57386606
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52862352
25Leishmaniasis_Homo sapiens_hsa051401.50719004
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49841488
27Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.49271125
28Osteoclast differentiation_Homo sapiens_hsa043801.46001950
29Legionellosis_Homo sapiens_hsa051341.43894411
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43557818
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43262737
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42258766
33Type I diabetes mellitus_Homo sapiens_hsa049401.39443231
34Synaptic vesicle cycle_Homo sapiens_hsa047211.38933554
35RNA transport_Homo sapiens_hsa030131.38034182
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34103201
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34042576
38Tuberculosis_Homo sapiens_hsa051521.31434832
39Sulfur metabolism_Homo sapiens_hsa009201.23301467
40RNA polymerase_Homo sapiens_hsa030201.19220303
41TNF signaling pathway_Homo sapiens_hsa046681.19135938
42Pertussis_Homo sapiens_hsa051331.18041111
43TGF-beta signaling pathway_Homo sapiens_hsa043501.15034609
44p53 signaling pathway_Homo sapiens_hsa041151.14555990
45Tryptophan metabolism_Homo sapiens_hsa003801.14251518
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12405013
47Chemical carcinogenesis_Homo sapiens_hsa052041.10978005
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.10954386
49Protein export_Homo sapiens_hsa030601.10588788
50Cell cycle_Homo sapiens_hsa041101.09336568
51Phototransduction_Homo sapiens_hsa047441.08992957
52Peroxisome_Homo sapiens_hsa041461.08676187
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07403335
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.07292231
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.04533082
56mTOR signaling pathway_Homo sapiens_hsa041501.04139585
57Other glycan degradation_Homo sapiens_hsa005111.03590783
58Long-term depression_Homo sapiens_hsa047301.03026171
59Long-term potentiation_Homo sapiens_hsa047201.02906506
60Butanoate metabolism_Homo sapiens_hsa006501.02327231
61Malaria_Homo sapiens_hsa051441.01952253
62Nucleotide excision repair_Homo sapiens_hsa034201.01506736
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01431743
64Nitrogen metabolism_Homo sapiens_hsa009101.00722052
65African trypanosomiasis_Homo sapiens_hsa051430.99123492
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98850672
67Fanconi anemia pathway_Homo sapiens_hsa034600.98638754
68Starch and sucrose metabolism_Homo sapiens_hsa005000.98543206
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97941437
70Sphingolipid metabolism_Homo sapiens_hsa006000.95763565
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95278148
72Insulin secretion_Homo sapiens_hsa049110.95078153
73Prolactin signaling pathway_Homo sapiens_hsa049170.94942224
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94618513
75Toxoplasmosis_Homo sapiens_hsa051450.94039500
76ECM-receptor interaction_Homo sapiens_hsa045120.93460258
77Amoebiasis_Homo sapiens_hsa051460.92446492
78Fatty acid biosynthesis_Homo sapiens_hsa000610.90506673
79Serotonergic synapse_Homo sapiens_hsa047260.90319569
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.89991084
81Regulation of autophagy_Homo sapiens_hsa041400.89418939
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.88921348
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88522527
84GnRH signaling pathway_Homo sapiens_hsa049120.88262624
85Cholinergic synapse_Homo sapiens_hsa047250.87914875
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87704663
87FoxO signaling pathway_Homo sapiens_hsa040680.87483236
88Insulin resistance_Homo sapiens_hsa049310.86651041
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86563974
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86529634
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.86204973
92N-Glycan biosynthesis_Homo sapiens_hsa005100.86195447
93Prion diseases_Homo sapiens_hsa050200.86147745
94Oocyte meiosis_Homo sapiens_hsa041140.85973274
95Glutathione metabolism_Homo sapiens_hsa004800.85725265
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85598425
97Chemokine signaling pathway_Homo sapiens_hsa040620.85398890
98Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85391871
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84780537
100Focal adhesion_Homo sapiens_hsa045100.84776072
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84711726
102Proteoglycans in cancer_Homo sapiens_hsa052050.83387199
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83118687
104Hepatitis C_Homo sapiens_hsa051600.82158961
105Dopaminergic synapse_Homo sapiens_hsa047280.81683914
106Circadian entrainment_Homo sapiens_hsa047130.79141724
107Glioma_Homo sapiens_hsa052140.78453411
108Influenza A_Homo sapiens_hsa051640.77757739
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77044427
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76644132
111Renal cell carcinoma_Homo sapiens_hsa052110.76170628
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.75603450
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.75329754
114Platelet activation_Homo sapiens_hsa046110.74532849
115Staphylococcus aureus infection_Homo sapiens_hsa051500.74462739
116Adherens junction_Homo sapiens_hsa045200.74113641
117Circadian rhythm_Homo sapiens_hsa047100.73712911
118Salmonella infection_Homo sapiens_hsa051320.73672933
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72737353
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72585294
121Estrogen signaling pathway_Homo sapiens_hsa049150.72313903
122Measles_Homo sapiens_hsa051620.71963309
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71941764
124Morphine addiction_Homo sapiens_hsa050320.71705810
125Mineral absorption_Homo sapiens_hsa049780.71604393
126Mismatch repair_Homo sapiens_hsa034300.71546243
127Dorso-ventral axis formation_Homo sapiens_hsa043200.71378131
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.70685150
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69803516
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69406664
131Renin secretion_Homo sapiens_hsa049240.69222586
132B cell receptor signaling pathway_Homo sapiens_hsa046620.68589465
133Olfactory transduction_Homo sapiens_hsa047400.68063617
134Graft-versus-host disease_Homo sapiens_hsa053320.67832003
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67651604
136MAPK signaling pathway_Homo sapiens_hsa040100.66182255
137Glutamatergic synapse_Homo sapiens_hsa047240.65994581
138Prostate cancer_Homo sapiens_hsa052150.64079049
139Ether lipid metabolism_Homo sapiens_hsa005650.63630453
140ErbB signaling pathway_Homo sapiens_hsa040120.63255598
141Shigellosis_Homo sapiens_hsa051310.62372288
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62208278
143Oxytocin signaling pathway_Homo sapiens_hsa049210.61797543
144Pancreatic cancer_Homo sapiens_hsa052120.61613142
145Hepatitis B_Homo sapiens_hsa051610.61183631
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60764673
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60665450
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59190041
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58257508
150Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57111083
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56666375
152Amphetamine addiction_Homo sapiens_hsa050310.56361277
153Retinol metabolism_Homo sapiens_hsa008300.56209910
154Homologous recombination_Homo sapiens_hsa034400.55740351
155Axon guidance_Homo sapiens_hsa043600.55478601
156Protein digestion and absorption_Homo sapiens_hsa049740.55242140
157Apoptosis_Homo sapiens_hsa042100.54898278
158Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54867904
159Endometrial cancer_Homo sapiens_hsa052130.54580406
160GABAergic synapse_Homo sapiens_hsa047270.54517385
161Gap junction_Homo sapiens_hsa045400.54251041
162Small cell lung cancer_Homo sapiens_hsa052220.50492210
163Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49958837
164Metabolic pathways_Homo sapiens_hsa011000.48687499
165Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45685953
166Pyruvate metabolism_Homo sapiens_hsa006200.44940578
167alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42771680
168Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42064699
169Linoleic acid metabolism_Homo sapiens_hsa005910.40508209
170Fatty acid metabolism_Homo sapiens_hsa012120.36961736
171Thyroid cancer_Homo sapiens_hsa052160.36904280
172ABC transporters_Homo sapiens_hsa020100.35055310
173One carbon pool by folate_Homo sapiens_hsa006700.34955065
174Purine metabolism_Homo sapiens_hsa002300.34469892
175Complement and coagulation cascades_Homo sapiens_hsa046100.34467311
176Arachidonic acid metabolism_Homo sapiens_hsa005900.34356247
177Fat digestion and absorption_Homo sapiens_hsa049750.31414792
178Renin-angiotensin system_Homo sapiens_hsa046140.29395408
179Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26388064
180mRNA surveillance pathway_Homo sapiens_hsa030150.24961409

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