TBC1D24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a conserved domain, referred to as the TBC domain, characteristic of proteins which interact with GTPases. TBC domain proteins may serve as GTPase-activating proteins for a particular group of GTPases, the Rab (Ras-related proteins in brain) small GTPases which are involved in the regulation of membrane trafficking. Mutations in this gene are associated with familial infantile myoclonic epilepsy. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1receptor recycling (GO:0001881)6.14940594
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.63536063
3vocalization behavior (GO:0071625)5.18976709
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.15708326
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.99282488
6locomotory exploration behavior (GO:0035641)4.95754878
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.87792812
8synaptic vesicle maturation (GO:0016188)4.85188573
9neuron cell-cell adhesion (GO:0007158)4.76672778
10protein localization to synapse (GO:0035418)4.72692400
11regulation of glutamate receptor signaling pathway (GO:1900449)4.56544528
12synaptic vesicle exocytosis (GO:0016079)4.53573975
13regulation of ARF protein signal transduction (GO:0032012)4.50285437
14glutamate secretion (GO:0014047)4.46134152
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.45050458
16layer formation in cerebral cortex (GO:0021819)4.29399518
17regulation of synaptic vesicle exocytosis (GO:2000300)4.25702152
18regulation of cAMP-dependent protein kinase activity (GO:2000479)4.23824258
19synaptic vesicle docking involved in exocytosis (GO:0016081)4.08453658
20regulation of glucokinase activity (GO:0033131)4.01907597
21regulation of hexokinase activity (GO:1903299)4.01907597
22exploration behavior (GO:0035640)3.98713214
23glutamate receptor signaling pathway (GO:0007215)3.96607273
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.93797376
25cerebellar Purkinje cell differentiation (GO:0021702)3.90604257
26dendritic spine morphogenesis (GO:0060997)3.86464917
27regulation of synaptic vesicle transport (GO:1902803)3.85494258
28neurotransmitter secretion (GO:0007269)3.84934941
29neurotransmitter-gated ion channel clustering (GO:0072578)3.84880211
30synaptic transmission, glutamatergic (GO:0035249)3.78991269
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.78414147
32neuron recognition (GO:0008038)3.73513948
33regulation of neuronal synaptic plasticity (GO:0048168)3.70650905
34inositol phosphate catabolic process (GO:0071545)3.69999008
35gamma-aminobutyric acid transport (GO:0015812)3.69686776
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69506173
37negative regulation of protein oligomerization (GO:0032460)3.62475773
38neuron-neuron synaptic transmission (GO:0007270)3.58822788
39positive regulation of glycolytic process (GO:0045821)3.54125601
40lactate metabolic process (GO:0006089)3.51256607
41sodium ion export (GO:0071436)3.49916254
42proline transport (GO:0015824)3.48616483
43axonal fasciculation (GO:0007413)3.47257558
44synaptic vesicle endocytosis (GO:0048488)3.46963557
45cellular ketone body metabolic process (GO:0046950)3.46362695
46negative regulation of organelle assembly (GO:1902116)3.43922931
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.42761595
48postsynaptic membrane organization (GO:0001941)3.41876302
49long-term memory (GO:0007616)3.40802269
50kidney morphogenesis (GO:0060993)3.39329926
51behavioral response to nicotine (GO:0035095)3.38025407
52dendrite morphogenesis (GO:0048813)3.37647985
53activation of protein kinase A activity (GO:0034199)3.32355604
54regulation of postsynaptic membrane potential (GO:0060078)3.31705968
55positive regulation of membrane potential (GO:0045838)3.29425900
56import into cell (GO:0098657)3.27799792
57pyrimidine nucleobase catabolic process (GO:0006208)3.27644542
58regulation of neurotransmitter secretion (GO:0046928)3.26384099
59neuronal action potential propagation (GO:0019227)3.25941809
60neurotransmitter transport (GO:0006836)3.25144567
61cellular response to epinephrine stimulus (GO:0071872)3.19783476
62neuromuscular process controlling balance (GO:0050885)3.18262024
63presynaptic membrane assembly (GO:0097105)3.18257228
64negative regulation of cytosolic calcium ion concentration (GO:0051481)3.18094987
65positive regulation of synapse maturation (GO:0090129)3.17663056
66ketone body metabolic process (GO:1902224)3.17555444
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16922090
68L-fucose catabolic process (GO:0042355)3.16528719
69fucose catabolic process (GO:0019317)3.16528719
70L-fucose metabolic process (GO:0042354)3.16528719
71positive regulation of dendritic spine morphogenesis (GO:0061003)3.15042798
72endocrine pancreas development (GO:0031018)3.14844032
73regulation of dendritic spine morphogenesis (GO:0061001)3.14280625
74regulation of type B pancreatic cell apoptotic process (GO:2000674)3.13727531
75transmission of nerve impulse (GO:0019226)3.13685362
76water-soluble vitamin biosynthetic process (GO:0042364)3.12325572
77regulation of synapse structural plasticity (GO:0051823)3.10902555
78membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08874656
79startle response (GO:0001964)3.07618160
80central nervous system projection neuron axonogenesis (GO:0021952)3.06551355
81positive regulation of neurotransmitter secretion (GO:0001956)3.05826893
82cell migration in hindbrain (GO:0021535)3.05659481
83inositol phosphate dephosphorylation (GO:0046855)2.99709406
84phosphorylated carbohydrate dephosphorylation (GO:0046838)2.99709406
85response to methylmercury (GO:0051597)2.99516656
86G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99344108
87nucleobase catabolic process (GO:0046113)2.98786310
88negative regulation of hormone biosynthetic process (GO:0032353)2.98341658
89polyol catabolic process (GO:0046174)2.98014935
90response to histamine (GO:0034776)2.95015465
91long-term synaptic potentiation (GO:0060291)2.94704134
92glycine transport (GO:0015816)2.94366392
93positive regulation of respiratory burst (GO:0060267)2.93908521
94regulation of neurotransmitter levels (GO:0001505)2.93875935
95response to pheromone (GO:0019236)2.93502880
96negative regulation of dendrite development (GO:2000171)2.93084645
97positive regulation of dendritic spine development (GO:0060999)2.92962399
98auditory behavior (GO:0031223)2.92764098
99protein localization to cilium (GO:0061512)2.91185524
100clathrin coat assembly (GO:0048268)2.89176265
101positive regulation of neurotransmitter transport (GO:0051590)2.89169642
102regulation of synaptic plasticity (GO:0048167)2.89167020
103negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89145280
104gamma-aminobutyric acid signaling pathway (GO:0007214)2.89006051
105regulation of neurotransmitter transport (GO:0051588)2.88923700
106synapse assembly (GO:0007416)2.88699642
107cellular potassium ion homeostasis (GO:0030007)2.88593440
108regulation of synaptic transmission, glutamatergic (GO:0051966)2.87099155
109L-amino acid import (GO:0043092)2.86823581
110keratinocyte development (GO:0003334)2.86701684
111presynaptic membrane organization (GO:0097090)2.86167527
112positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.85367318
113social behavior (GO:0035176)2.85337943
114intraspecies interaction between organisms (GO:0051703)2.85337943
115regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.84113144
116behavioral defense response (GO:0002209)2.84021123
117behavioral fear response (GO:0001662)2.84021123
118response to epinephrine (GO:0071871)2.83358475
119dentate gyrus development (GO:0021542)2.82388359
120membrane depolarization (GO:0051899)2.82373964
121cellular response to monoamine stimulus (GO:0071868)2.81429713
122cellular response to catecholamine stimulus (GO:0071870)2.81429713
123membrane hyperpolarization (GO:0060081)2.79600998
124learning (GO:0007612)2.78504736
125innervation (GO:0060384)2.77600397
126neuromuscular process (GO:0050905)2.76495250
127detection of light stimulus involved in visual perception (GO:0050908)2.74391905
128detection of light stimulus involved in sensory perception (GO:0050962)2.74391905
129negative regulation of gluconeogenesis (GO:0045721)2.73089118
130nitric oxide mediated signal transduction (GO:0007263)2.72345421
131detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.68842223
132positive regulation of protein autophosphorylation (GO:0031954)2.68708774
133insulin secretion (GO:0030073)2.66696425
134neuronal action potential (GO:0019228)2.65112085
135limb bud formation (GO:0060174)2.63346511
136positive regulation of glycogen biosynthetic process (GO:0045725)2.59480118
137regulation of calcium ion-dependent exocytosis (GO:0017158)2.57497722
138signal peptide processing (GO:0006465)2.57445667
139glycerophospholipid catabolic process (GO:0046475)2.57354327
140positive regulation of peptide hormone secretion (GO:0090277)2.55874911
141membrane depolarization during action potential (GO:0086010)2.53930088
142positive regulation of growth hormone secretion (GO:0060124)2.51921042
143negative regulation of acute inflammatory response (GO:0002674)2.48824260
144positive regulation of peptide secretion (GO:0002793)2.48396655
145hindbrain development (GO:0030902)2.47563950
146cornea development in camera-type eye (GO:0061303)2.47393558
147regulation of neurotransmitter uptake (GO:0051580)2.47200143
148positive regulation of insulin secretion (GO:0032024)2.47058865
149retinal ganglion cell axon guidance (GO:0031290)2.45518505
150reflex (GO:0060004)2.41628316
151regulation of action potential (GO:0098900)2.41008648
152negative regulation of hormone metabolic process (GO:0032351)2.40904306
153spinal cord development (GO:0021510)2.39683468
154glycosphingolipid biosynthetic process (GO:0006688)2.39657508
155mechanosensory behavior (GO:0007638)2.37707449
156regulation of feeding behavior (GO:0060259)2.37419090
157positive regulation of meiosis (GO:0045836)2.37362880
158dopamine transport (GO:0015872)2.36309227
159axoneme assembly (GO:0035082)2.36002518
160spinal cord motor neuron differentiation (GO:0021522)2.33356245
161inner ear receptor stereocilium organization (GO:0060122)2.32924222
162positive regulation of glycogen metabolic process (GO:0070875)2.32200860
163fatty acid homeostasis (GO:0055089)2.31283531
164brain morphogenesis (GO:0048854)2.31267432
165action potential (GO:0001508)2.28258990
166nephron tubule morphogenesis (GO:0072078)2.27625607
167nephron epithelium morphogenesis (GO:0072088)2.27625607
168respiratory chain complex IV assembly (GO:0008535)2.27163467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.40766551
2GBX2_23144817_ChIP-Seq_PC3_Human3.68723716
3GATA1_22025678_ChIP-Seq_K562_Human3.00053374
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71677895
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68939234
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.64155489
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53449367
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.50621123
9REST_21632747_ChIP-Seq_MESCs_Mouse2.47321614
10VDR_22108803_ChIP-Seq_LS180_Human2.42583299
11DROSHA_22980978_ChIP-Seq_HELA_Human2.28158336
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26936214
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26936214
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24208121
15IKZF1_21737484_ChIP-ChIP_HCT116_Human2.23457119
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.21750634
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20109804
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18530886
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.18151965
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.15405783
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.14810830
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14613180
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13786174
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10014462
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.07699925
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05745593
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03684662
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.00609116
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.00537685
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.90449767
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.90398042
32FUS_26573619_Chip-Seq_HEK293_Human1.88583134
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85119369
34AR_21572438_ChIP-Seq_LNCaP_Human1.82873094
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78257962
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76436583
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.75889835
38BCAT_22108803_ChIP-Seq_LS180_Human1.75783105
39EWS_26573619_Chip-Seq_HEK293_Human1.75548745
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70227893
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58291768
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54404741
43SMAD4_21799915_ChIP-Seq_A2780_Human1.52570875
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50737268
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.50712469
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44820403
47UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43632085
48CBP_20019798_ChIP-Seq_JUKART_Human1.43032230
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43032230
50TAF15_26573619_Chip-Seq_HEK293_Human1.42970571
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.42886865
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39553889
53P300_19829295_ChIP-Seq_ESCs_Human1.39219332
54IGF1R_20145208_ChIP-Seq_DFB_Human1.39074301
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.34808746
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34044830
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.31827120
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27353867
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26345823
60* GATA1_19941826_ChIP-Seq_K562_Human1.26235894
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25257295
62* AR_19668381_ChIP-Seq_PC3_Human1.24836904
63STAT3_23295773_ChIP-Seq_U87_Human1.24256537
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24175134
65TP53_22573176_ChIP-Seq_HFKS_Human1.23439970
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.22892661
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.22680106
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.21968669
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21888194
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21422095
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20999306
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.20876689
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20719137
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19917356
75TP53_16413492_ChIP-PET_HCT116_Human1.19890802
76TCF4_22108803_ChIP-Seq_LS180_Human1.19638087
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.19498615
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18902691
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18729821
80SMAD_19615063_ChIP-ChIP_OVARY_Human1.17923896
81AR_25329375_ChIP-Seq_VCAP_Human1.17361409
82TCF4_23295773_ChIP-Seq_U87_Human1.17315163
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16656677
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.16179886
85P53_22387025_ChIP-Seq_ESCs_Mouse1.15804297
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.15480311
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15255233
88* RING1B_27294783_Chip-Seq_ESCs_Mouse1.14941250
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14049914
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13689567
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.13312603
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12233267
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12099132
94POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11647155
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11550231
96NANOG_19829295_ChIP-Seq_ESCs_Human1.11519249
97SOX2_19829295_ChIP-Seq_ESCs_Human1.11519249
98KDM2B_26808549_Chip-Seq_K562_Human1.11379052
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11190328
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10989990
101* GATA1_19941827_ChIP-Seq_MEL_Mouse1.10383743
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09528216
103TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08876827
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07547915
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07484440
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06277666
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06083072
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.05745208
109KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.04807120
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03907339
111BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03826035
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03766600
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.03627210
114YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03391882
115E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02529697
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.02490443
117RUNX2_22187159_ChIP-Seq_PCA_Human1.02389538
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.02021055
119CMYC_18555785_Chip-Seq_ESCs_Mouse1.01759488
120AHR_22903824_ChIP-Seq_MCF-7_Human1.00329501
121ER_23166858_ChIP-Seq_MCF-7_Human0.99235177
122ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99015521
123GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98391077
124RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96975808
125ZNF274_21170338_ChIP-Seq_K562_Hela0.96737709
126SMAD3_21741376_ChIP-Seq_HESCs_Human0.96230059
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95582576
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.94480116
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93635293
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93635293
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93455856
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93318644
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92986287
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92955713
135SMAD4_21741376_ChIP-Seq_HESCs_Human0.91275068
136NANOG_18555785_Chip-Seq_ESCs_Mouse0.90330778
137MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90296228
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89064118
139TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88686028
140RNF2_27304074_Chip-Seq_NSC_Mouse0.87184364

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.25959671
2MP0003880_abnormal_central_pattern4.36377245
3MP0003635_abnormal_synaptic_transmissio3.87260192
4MP0004270_analgesia3.28935758
5MP0002063_abnormal_learning/memory/cond3.20606720
6MP0009745_abnormal_behavioral_response3.14704174
7MP0002064_seizures3.09389754
8MP0005423_abnormal_somatic_nervous3.02615838
9MP0009046_muscle_twitch2.89617954
10MP0003195_calcinosis2.77419220
11MP0002572_abnormal_emotion/affect_behav2.76177517
12MP0001440_abnormal_grooming_behavior2.65679835
13MP0008877_abnormal_DNA_methylation2.64317199
14MP0001486_abnormal_startle_reflex2.53179768
15MP0001968_abnormal_touch/_nociception2.49695404
16MP0005551_abnormal_eye_electrophysiolog2.47445224
17MP0003283_abnormal_digestive_organ2.43360571
18MP0002102_abnormal_ear_morphology2.41583279
19MP0002734_abnormal_mechanical_nocicepti2.38106975
20MP0002272_abnormal_nervous_system2.25800661
21MP0003787_abnormal_imprinting2.09194744
22MP0000778_abnormal_nervous_system2.03164023
23MP0002938_white_spotting1.98717431
24MP0003656_abnormal_erythrocyte_physiolo1.97245426
25MP0000569_abnormal_digit_pigmentation1.96937424
26MP0002067_abnormal_sensory_capabilities1.96148992
27MP0001501_abnormal_sleep_pattern1.79016497
28MP0002735_abnormal_chemical_nociception1.77951949
29MP0002733_abnormal_thermal_nociception1.77523831
30MP0004811_abnormal_neuron_physiology1.75620637
31MP0004924_abnormal_behavior1.75378902
32MP0005386_behavior/neurological_phenoty1.75378902
33MP0002184_abnormal_innervation1.75355638
34MP0002557_abnormal_social/conspecific_i1.72567494
35MP0002736_abnormal_nociception_after1.72013555
36MP0002876_abnormal_thyroid_physiology1.71967164
37MP0001970_abnormal_pain_threshold1.69354003
38MP0009780_abnormal_chondrocyte_physiolo1.68602054
39MP0004885_abnormal_endolymph1.68237333
40MP0002837_dystrophic_cardiac_calcinosis1.67836710
41MP0002822_catalepsy1.65146110
42MP0002882_abnormal_neuron_morphology1.63535518
43MP0008569_lethality_at_weaning1.61645350
44MP0006276_abnormal_autonomic_nervous1.61334453
45MP0003121_genomic_imprinting1.58496575
46MP0000955_abnormal_spinal_cord1.58179427
47MP0002229_neurodegeneration1.54867362
48MP0005645_abnormal_hypothalamus_physiol1.54336118
49MP0005646_abnormal_pituitary_gland1.52176373
50MP0003879_abnormal_hair_cell1.51192646
51MP0001944_abnormal_pancreas_morphology1.48023081
52MP0002928_abnormal_bile_duct1.48013800
53MP0003011_delayed_dark_adaptation1.46480458
54MP0003329_amyloid_beta_deposits1.46219358
55MP0001986_abnormal_taste_sensitivity1.45803265
56MP0001984_abnormal_olfaction1.45800557
57MP0002090_abnormal_vision1.44484929
58MP0001502_abnormal_circadian_rhythm1.42311607
59MP0002066_abnormal_motor_capabilities/c1.41802476
60MP0003122_maternal_imprinting1.37064685
61MP0005253_abnormal_eye_physiology1.36008925
62MP0005220_abnormal_exocrine_pancreas1.34542856
63MP0000516_abnormal_urinary_system1.31241024
64MP0005367_renal/urinary_system_phenotyp1.31241024
65MP0003633_abnormal_nervous_system1.30796047
66MP0004043_abnormal_pH_regulation1.30654226
67MP0005083_abnormal_biliary_tract1.28169888
68MP0003123_paternal_imprinting1.27503583
69MP0002163_abnormal_gland_morphology1.26508215
70MP0004858_abnormal_nervous_system1.26453655
71MP0002152_abnormal_brain_morphology1.26132459
72MP0004133_heterotaxia1.24821480
73MP0002909_abnormal_adrenal_gland1.23117822
74MP0001485_abnormal_pinna_reflex1.22903268
75MP0003172_abnormal_lysosome_physiology1.22842144
76MP0004142_abnormal_muscle_tone1.19214907
77MP0004147_increased_porphyrin_level1.18960075
78MP0010386_abnormal_urinary_bladder1.17548363
79MP0003631_nervous_system_phenotype1.16954923
80MP0008872_abnormal_physiological_respon1.14481763
81MP0002693_abnormal_pancreas_physiology1.13573761
82MP0006072_abnormal_retinal_apoptosis1.13228569
83MP0001529_abnormal_vocalization1.13036550
84MP0003119_abnormal_digestive_system1.12168981
85MP0000427_abnormal_hair_cycle1.10375603
86MP0002751_abnormal_autonomic_nervous1.08368616
87MP0004510_myositis1.06139520
88MP0005379_endocrine/exocrine_gland_phen1.06056438
89MP0002752_abnormal_somatic_nervous1.03707333
90MP0003634_abnormal_glial_cell1.00239402
91MP0004742_abnormal_vestibular_system0.99684789
92MP0002069_abnormal_eating/drinking_beha0.97407848
93MP0002160_abnormal_reproductive_system0.97309377
94MP0002234_abnormal_pharynx_morphology0.96429450
95MP0000631_abnormal_neuroendocrine_gland0.94865067
96MP0001188_hyperpigmentation0.94342607
97MP0001905_abnormal_dopamine_level0.93491414
98MP0003632_abnormal_nervous_system0.92302844
99MP0005195_abnormal_posterior_eye0.92065094
100MP0000538_abnormal_urinary_bladder0.90405788
101MP0005535_abnormal_body_temperature0.89160379
102MP0003690_abnormal_glial_cell0.87775176
103MP0000566_synostosis0.87167015
104MP0000639_abnormal_adrenal_gland0.85236370
105MP0002638_abnormal_pupillary_reflex0.83194909
106MP0001756_abnormal_urination0.80982486
107MP0008875_abnormal_xenobiotic_pharmacok0.80968994
108MP0001963_abnormal_hearing_physiology0.80967164
109MP0005075_abnormal_melanosome_morpholog0.80649980
110MP0004130_abnormal_muscle_cell0.79273017
111MP0005448_abnormal_energy_balance0.78349171
112MP0010234_abnormal_vibrissa_follicle0.76678860
113MP0002078_abnormal_glucose_homeostasis0.75693812
114MP0000372_irregular_coat_pigmentation0.75387863
115MP0000920_abnormal_myelination0.74194403
116MP0004085_abnormal_heartbeat0.73909643
117MP0004484_altered_response_of0.71834186
118MP0003938_abnormal_ear_development0.71725119
119MP0005187_abnormal_penis_morphology0.71426601
120MP0008961_abnormal_basal_metabolism0.70362626
121MP0005394_taste/olfaction_phenotype0.69906681
122MP0005499_abnormal_olfactory_system0.69906681
123MP0003861_abnormal_nervous_system0.68639472
124MP0000604_amyloidosis0.67573204
125MP0008874_decreased_physiological_sensi0.65024853
126MP0000751_myopathy0.64692366
127MP0001324_abnormal_eye_pigmentation0.64333491
128MP0001177_atelectasis0.60612106
129MP0010329_abnormal_lipoprotein_level0.60107006
130MP0005409_darkened_coat_color0.59434717
131MP0004145_abnormal_muscle_electrophysio0.58823618
132MP0010769_abnormal_survival0.58120556
133MP0010770_preweaning_lethality0.57669208
134MP0002082_postnatal_lethality0.57669208
135MP0000026_abnormal_inner_ear0.56772601
136MP0010768_mortality/aging0.55688476
137MP0006292_abnormal_olfactory_placode0.54935835

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.78669825
2Poor eye contact (HP:0000817)5.38137902
3Impaired social interactions (HP:0000735)4.87246040
4Abnormal social behavior (HP:0012433)4.87246040
5* Focal seizures (HP:0007359)4.86751696
6Myokymia (HP:0002411)4.45225641
7* Epileptic encephalopathy (HP:0200134)4.37471301
8Visual hallucinations (HP:0002367)4.31375234
9Poikilocytosis (HP:0004447)4.23135862
10Tetraparesis (HP:0002273)4.14612429
11* Febrile seizures (HP:0002373)4.06574733
12Hypoglycemic seizures (HP:0002173)3.85958470
13Hyperinsulinemic hypoglycemia (HP:0000825)3.76739915
14Supranuclear gaze palsy (HP:0000605)3.73856051
15Heterotopia (HP:0002282)3.69093175
16Abnormality of the labia minora (HP:0012880)3.66782260
17Ketoacidosis (HP:0001993)3.60194045
18Progressive cerebellar ataxia (HP:0002073)3.56880720
19Congenital stationary night blindness (HP:0007642)3.56433134
20Epileptiform EEG discharges (HP:0011182)3.55139191
21EEG with generalized epileptiform discharges (HP:0011198)3.54759027
22Hypsarrhythmia (HP:0002521)3.48109675
23* Generalized tonic-clonic seizures (HP:0002069)3.46785525
24Atonic seizures (HP:0010819)3.44465133
25Absence seizures (HP:0002121)3.41400734
26Pancreatic fibrosis (HP:0100732)3.35355560
27Pancreatic cysts (HP:0001737)3.33396248
28Hypothermia (HP:0002045)3.32119664
29Dialeptic seizures (HP:0011146)3.30549565
30Hypoglycemic coma (HP:0001325)3.29183708
31Neoplasm of the adrenal cortex (HP:0100641)3.27587893
32Cystic liver disease (HP:0006706)3.26773635
33Broad-based gait (HP:0002136)3.22655519
34Depression (HP:0000716)3.17636580
35Hyperventilation (HP:0002883)3.17320668
36Molar tooth sign on MRI (HP:0002419)3.12017019
37Abnormality of midbrain morphology (HP:0002418)3.12017019
38Action tremor (HP:0002345)3.08980200
39Cerebral inclusion bodies (HP:0100314)3.06746007
40Excessive salivation (HP:0003781)3.05245443
41Drooling (HP:0002307)3.05245443
42Dysdiadochokinesis (HP:0002075)3.04386325
43Nephronophthisis (HP:0000090)3.04158122
44Large for gestational age (HP:0001520)3.03513871
45Protruding tongue (HP:0010808)3.01959552
46Neurofibrillary tangles (HP:0002185)2.99941631
47Acanthocytosis (HP:0001927)2.99619054
48Postural instability (HP:0002172)2.96114802
49Abnormality of the pancreatic islet cells (HP:0006476)2.90094766
50Abnormality of endocrine pancreas physiology (HP:0012093)2.90094766
51True hermaphroditism (HP:0010459)2.89801188
52Hyperglycemia (HP:0003074)2.88088977
53Mutism (HP:0002300)2.87881180
54Hypomagnesemia (HP:0002917)2.86178673
55Abnormality of binocular vision (HP:0011514)2.85276973
56Diplopia (HP:0000651)2.85276973
57Dyschromatopsia (HP:0007641)2.84863194
58Progressive inability to walk (HP:0002505)2.84580494
59Truncal ataxia (HP:0002078)2.83452735
60Ankle clonus (HP:0011448)2.77085165
61Urinary bladder sphincter dysfunction (HP:0002839)2.76767666
62Enlarged penis (HP:0000040)2.75757807
63Bradykinesia (HP:0002067)2.74396187
64Gaze-evoked nystagmus (HP:0000640)2.69530271
65Central scotoma (HP:0000603)2.67837697
66* Status epilepticus (HP:0002133)2.65200991
67Abnormal drinking behavior (HP:0030082)2.65018787
68Polydipsia (HP:0001959)2.65018787
69Impaired vibration sensation in the lower limbs (HP:0002166)2.64070774
70Anxiety (HP:0000739)2.62945549
71Abnormality of the renal medulla (HP:0100957)2.62157509
72Absent speech (HP:0001344)2.58285547
73Ketosis (HP:0001946)2.54312188
74Abnormality of macular pigmentation (HP:0008002)2.54127173
75Impaired vibratory sensation (HP:0002495)2.50464467
76Abnormality of the renal cortex (HP:0011035)2.47625370
77Lower limb amyotrophy (HP:0007210)2.44501636
78Reticulocytosis (HP:0001923)2.39307390
79Symptomatic seizures (HP:0011145)2.38478506
80Dysmetria (HP:0001310)2.38134754
81Abnormality of ocular smooth pursuit (HP:0000617)2.37932846
82Abnormality of the metopic suture (HP:0005556)2.37413494
83Abnormality of the corticospinal tract (HP:0002492)2.36252579
84Clumsiness (HP:0002312)2.35550812
85Blue irides (HP:0000635)2.33839443
86Genetic anticipation (HP:0003743)2.33664871
87Insomnia (HP:0100785)2.32733614
88* Hemiparesis (HP:0001269)2.30295971
89Impaired smooth pursuit (HP:0007772)2.28498650
90Macroorchidism (HP:0000053)2.25884576
91Neuronal loss in central nervous system (HP:0002529)2.24649175
92Intention tremor (HP:0002080)2.24313553
93Methylmalonic acidemia (HP:0002912)2.23437526
94Aqueductal stenosis (HP:0002410)2.22979944
95Bony spicule pigmentary retinopathy (HP:0007737)2.22427248
96Medial flaring of the eyebrow (HP:0010747)2.20737645
97Chronic hepatic failure (HP:0100626)2.20504315
98Inability to walk (HP:0002540)2.18746905
99Spastic gait (HP:0002064)2.17310503
100Fair hair (HP:0002286)2.17253092
101Inappropriate behavior (HP:0000719)2.16868035
102Agitation (HP:0000713)2.15461806
103Intestinal atresia (HP:0011100)2.13987507
104Resting tremor (HP:0002322)2.13703724
105Amblyopia (HP:0000646)2.13264861
106Hamartoma of the eye (HP:0010568)2.12233849
107Lower limb muscle weakness (HP:0007340)2.10219128
108Abnormality of magnesium homeostasis (HP:0004921)2.06282025
109Progressive macrocephaly (HP:0004481)2.05780332
110Stereotypic behavior (HP:0000733)2.05701835
111Generalized hypopigmentation of hair (HP:0011358)2.05575563
112Furrowed tongue (HP:0000221)2.04882215
113Tubular atrophy (HP:0000092)2.03956952
114Cortical visual impairment (HP:0100704)2.03512106
115Termporal pattern (HP:0011008)2.03013424
116Insidious onset (HP:0003587)2.03013424
117Prominent metopic ridge (HP:0005487)2.02053455
118Polyuria (HP:0000103)2.01485925
119Type II lissencephaly (HP:0007260)2.01414802
120Astrocytoma (HP:0009592)2.00934551
121Abnormality of the astrocytes (HP:0100707)2.00934551
122Abnormal pancreas size (HP:0012094)2.00071941
123Torticollis (HP:0000473)1.97720316
124Scotoma (HP:0000575)1.97201384
125Polyphagia (HP:0002591)1.92888601
126Dysmetric saccades (HP:0000641)1.91085370
127Akinesia (HP:0002304)1.90489541
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.90297449
129Abnormality of the lower motor neuron (HP:0002366)1.89852938
130Abnormal eating behavior (HP:0100738)1.88682258
131Abnormality of salivation (HP:0100755)1.88541957
132Gait imbalance (HP:0002141)1.86777004
133Psychosis (HP:0000709)1.86292970
134Pancreatic islet-cell hyperplasia (HP:0004510)1.86272995
135Fetal akinesia sequence (HP:0001989)1.86209582
136Urinary urgency (HP:0000012)1.86183926
137Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86094690
138Abolished electroretinogram (ERG) (HP:0000550)1.85439976
139Hepatoblastoma (HP:0002884)1.85278509
140Abnormal rod and cone electroretinograms (HP:0008323)1.84154501
141Abnormality of the heme biosynthetic pathway (HP:0010472)1.83947565
142Limb dystonia (HP:0002451)1.82860030
143Sclerocornea (HP:0000647)1.82265834
144Insulin-resistant diabetes mellitus (HP:0000831)1.80733895
145Muscular hypotonia of the trunk (HP:0008936)1.80366679
146Ependymoma (HP:0002888)1.80098929
147Adrenal hypoplasia (HP:0000835)1.79078318
148Sporadic (HP:0003745)1.78768055
149Genital tract atresia (HP:0001827)1.78542335
150Shawl scrotum (HP:0000049)1.78411987
151Gait ataxia (HP:0002066)1.78314062
152Aplasia/Hypoplasia of the fovea (HP:0008060)1.77611256
153Hypoplasia of the fovea (HP:0007750)1.77611256
154Hypoplasia of the corpus callosum (HP:0002079)1.76890874
155Decreased central vision (HP:0007663)1.76795891
156* Generalized myoclonic seizures (HP:0002123)1.76656682
157Focal dystonia (HP:0004373)1.75798337
158Optic nerve hypoplasia (HP:0000609)1.75498221
159Chorioretinal atrophy (HP:0000533)1.75077211
160Pendular nystagmus (HP:0012043)1.74666352
161Increased circulating renin level (HP:0000848)1.73677664
162Glioma (HP:0009733)1.73592769
163Congenital, generalized hypertrichosis (HP:0004540)1.72835559
164Methylmalonic aciduria (HP:0012120)1.72826213
165Patellar aplasia (HP:0006443)1.71259106
166Late onset (HP:0003584)1.70076283
167Keratoconus (HP:0000563)1.69439680
168Increased corneal curvature (HP:0100692)1.69439680
169Renal cortical cysts (HP:0000803)1.69321194
170Hepatic necrosis (HP:0002605)1.68732155
171Disproportionate short-trunk short stature (HP:0003521)1.67580543
172Metaphyseal dysplasia (HP:0100255)1.64856021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.91763878
2MARK14.44379366
3NTRK33.82959812
4EPHA43.55877039
5MAP3K43.23764048
6MAP2K73.07476914
7MAP3K92.91926941
8FGFR22.76418783
9WNK32.60728403
10RIPK42.54485673
11DAPK22.44767895
12MINK12.16987630
13MAP2K42.13338876
14BMPR1B2.08613304
15NTRK22.06547149
16CASK2.03895342
17SIK21.89615122
18PAK61.86814467
19ADRBK21.73435444
20STK391.65616390
21WNK41.65498150
22NUAK11.65310440
23MAP4K21.64242994
24MAPK131.63234083
25TNIK1.62993631
26CAMKK11.62488644
27PRPF4B1.61765209
28TRIM281.48575974
29CDK51.43942214
30NTRK11.43274988
31KSR11.39959397
32SGK21.38636535
33PLK21.37866288
34CAMK1G1.32963538
35OXSR11.32540572
36ACVR1B1.32429040
37MKNK21.27911872
38TAOK31.26689663
39SGK4941.26222921
40SGK2231.26222921
41MAP3K121.24796753
42GRK51.23129767
43PASK1.21002684
44DAPK11.20247106
45SGK31.17007689
46ZAK1.15941976
47UHMK11.15877812
48CSNK1G11.13683313
49STK38L1.13250763
50BRSK21.10821581
51PNCK1.08590726
52PRKCG1.04665809
53PHKG21.03604185
54PHKG11.03604185
55PLK31.03344922
56DYRK1A1.00873582
57TAOK11.00814297
58MAP3K60.98890746
59CSNK1G30.98447102
60KSR20.95654068
61FER0.94608165
62SGK10.92988374
63STK380.90475344
64RET0.89702539
65PKN10.86683310
66CAMK2A0.86365404
67PRKD30.85219706
68NLK0.84898125
69CAMKK20.83961974
70MARK20.83801677
71STK160.83609894
72STK110.83556964
73CAMK10.83213642
74CAMK1D0.80864505
75PRKCZ0.79346975
76FES0.78921582
77RPS6KA20.76808846
78GRK10.76300804
79MAP3K20.76090559
80WEE10.74153682
81ADRBK10.74126429
82CSNK1G20.73736782
83BMX0.72430475
84CSNK1A1L0.71626171
85TYRO30.71248978
86LATS20.66616846
87ERBB30.66049981
88RPS6KA30.64764375
89CDK180.61400954
90DYRK1B0.61147940
91CDK150.60450783
92ALK0.60363652
93CAMK40.60125979
94PDPK10.59457765
95PRKAA20.59289522
96PTK2B0.58893496
97CDK140.57550003
98AKT30.57134854
99PAK30.56875380
100PTK20.56481571
101CDK190.55796047
102PRKAA10.55491332
103CSNK1D0.55304569
104MAPK100.54972991
105TIE10.54798216
106CAMK2D0.54582026
107EIF2AK10.54311844
108TLK10.54064679
109MAPK120.54047183
110BCR0.53843524
111MAP3K70.53616629
112BMPR20.53078519
113CAMK2B0.52237280
114PRKCE0.50750555
115MAPKAPK50.50269693
116ERBB20.50037978
117CDK11A0.49766385
118PRKCH0.49319412
119FGR0.48659693
120PDK10.48390313
121PINK10.48317598
122INSRR0.48017674
123ROCK10.46399372
124DYRK20.44951575
125MAPKAPK30.42889842
126HIPK20.42442195
127STK30.41915403
128VRK10.41406007
129CSNK1A10.40989538
130FYN0.40251392
131PRKACA0.39563154
132PRKCI0.37720571
133RIPK10.37469634
134BRD40.37427343
135PRKCB0.37379859
136BRSK10.37287237
137MAP2K60.36799026
138PRKACG0.36361834
139FGFR30.35123412
140PRKG10.34992425
141ATM0.34953439
142CDK30.34667980
143MAPK80.34249057
144GSK3B0.34035831
145CDC42BPA0.33718215
146CSNK1E0.30311654
147PRKCA0.30224781
148TRPM70.30131930
149PLK10.29311106

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.88039595
2Nicotine addiction_Homo sapiens_hsa050333.52767038
3Protein export_Homo sapiens_hsa030603.46382239
4Synaptic vesicle cycle_Homo sapiens_hsa047213.10251715
5Phototransduction_Homo sapiens_hsa047443.08135594
6GABAergic synapse_Homo sapiens_hsa047272.64955649
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.50124578
8Olfactory transduction_Homo sapiens_hsa047402.45825395
9Glutamatergic synapse_Homo sapiens_hsa047242.43950101
10Circadian entrainment_Homo sapiens_hsa047132.40431779
11Morphine addiction_Homo sapiens_hsa050322.39811003
12Salivary secretion_Homo sapiens_hsa049702.17315626
13Long-term potentiation_Homo sapiens_hsa047202.06775698
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97073226
15Amphetamine addiction_Homo sapiens_hsa050311.95889788
16Dopaminergic synapse_Homo sapiens_hsa047281.90958471
17Cholinergic synapse_Homo sapiens_hsa047251.75659507
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74025321
19Insulin secretion_Homo sapiens_hsa049111.72780874
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67533550
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.66307237
22Tryptophan metabolism_Homo sapiens_hsa003801.61659818
23Gastric acid secretion_Homo sapiens_hsa049711.60036787
24Selenocompound metabolism_Homo sapiens_hsa004501.59025795
25Homologous recombination_Homo sapiens_hsa034401.54940957
26Serotonergic synapse_Homo sapiens_hsa047261.53981273
27Taste transduction_Homo sapiens_hsa047421.53170660
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50165883
29Propanoate metabolism_Homo sapiens_hsa006401.47086679
30Oxytocin signaling pathway_Homo sapiens_hsa049211.45308198
31Calcium signaling pathway_Homo sapiens_hsa040201.43749262
32Collecting duct acid secretion_Homo sapiens_hsa049661.43645783
33Renin secretion_Homo sapiens_hsa049241.43073438
34Oxidative phosphorylation_Homo sapiens_hsa001901.41999270
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41746817
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39879892
37Long-term depression_Homo sapiens_hsa047301.39642301
38Cocaine addiction_Homo sapiens_hsa050301.38849589
39Linoleic acid metabolism_Homo sapiens_hsa005911.34798962
40Type II diabetes mellitus_Homo sapiens_hsa049301.33228665
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31847031
42Gap junction_Homo sapiens_hsa045401.30530422
43GnRH signaling pathway_Homo sapiens_hsa049121.28377475
44Regulation of autophagy_Homo sapiens_hsa041401.27462440
45Fanconi anemia pathway_Homo sapiens_hsa034601.26645571
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24151201
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22590960
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22304109
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18290574
50cAMP signaling pathway_Homo sapiens_hsa040241.13817740
51Axon guidance_Homo sapiens_hsa043601.13331770
52Ether lipid metabolism_Homo sapiens_hsa005651.12983737
53Caffeine metabolism_Homo sapiens_hsa002321.10936265
54Nitrogen metabolism_Homo sapiens_hsa009101.10034590
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09432465
56ErbB signaling pathway_Homo sapiens_hsa040121.08899064
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04605885
58Bile secretion_Homo sapiens_hsa049761.01877536
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01507769
60Glioma_Homo sapiens_hsa052141.00878490
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96794907
62Basal transcription factors_Homo sapiens_hsa030220.95874144
63ABC transporters_Homo sapiens_hsa020100.94458629
64Fatty acid metabolism_Homo sapiens_hsa012120.93872289
65Peroxisome_Homo sapiens_hsa041460.92181049
66Non-homologous end-joining_Homo sapiens_hsa034500.92004161
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91577964
68Estrogen signaling pathway_Homo sapiens_hsa049150.90883573
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90775648
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87058570
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86720588
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85897989
73Parkinsons disease_Homo sapiens_hsa050120.85206679
74Melanogenesis_Homo sapiens_hsa049160.82256690
75Steroid biosynthesis_Homo sapiens_hsa001000.80632262
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80318428
77Choline metabolism in cancer_Homo sapiens_hsa052310.79660230
78beta-Alanine metabolism_Homo sapiens_hsa004100.78793926
79Fatty acid elongation_Homo sapiens_hsa000620.77692372
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75235516
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.74938389
82Pancreatic secretion_Homo sapiens_hsa049720.73216852
83Fatty acid degradation_Homo sapiens_hsa000710.71753722
84Lysine degradation_Homo sapiens_hsa003100.71634113
85Circadian rhythm_Homo sapiens_hsa047100.71498565
86Dorso-ventral axis formation_Homo sapiens_hsa043200.69826996
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.69175036
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67658877
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67543998
90One carbon pool by folate_Homo sapiens_hsa006700.67433397
91Alzheimers disease_Homo sapiens_hsa050100.66277205
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64598205
93Retinol metabolism_Homo sapiens_hsa008300.64343299
94RNA polymerase_Homo sapiens_hsa030200.62667435
95RNA degradation_Homo sapiens_hsa030180.62606366
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62281546
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61741542
98mTOR signaling pathway_Homo sapiens_hsa041500.60926266
99Sulfur metabolism_Homo sapiens_hsa009200.60889438
100Dilated cardiomyopathy_Homo sapiens_hsa054140.59919805
101Vibrio cholerae infection_Homo sapiens_hsa051100.59713784
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58997663
103Hedgehog signaling pathway_Homo sapiens_hsa043400.58385895
104Glucagon signaling pathway_Homo sapiens_hsa049220.57873796
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.57639018
106Insulin signaling pathway_Homo sapiens_hsa049100.57193500
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57017913
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56036759
109Mineral absorption_Homo sapiens_hsa049780.55039210
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.54816100
111Prion diseases_Homo sapiens_hsa050200.53631588
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53299149
113Cardiac muscle contraction_Homo sapiens_hsa042600.53076958
114Arginine biosynthesis_Homo sapiens_hsa002200.52975566
115Inositol phosphate metabolism_Homo sapiens_hsa005620.52580272
116MAPK signaling pathway_Homo sapiens_hsa040100.52575063
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.51927695
118Ovarian steroidogenesis_Homo sapiens_hsa049130.50700741
119Vitamin B6 metabolism_Homo sapiens_hsa007500.50598272
120Butanoate metabolism_Homo sapiens_hsa006500.50167691
121Chemical carcinogenesis_Homo sapiens_hsa052040.49810960
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48919501
123Thyroid hormone synthesis_Homo sapiens_hsa049180.48586449
124Endometrial cancer_Homo sapiens_hsa052130.48447971
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47937185
126Non-small cell lung cancer_Homo sapiens_hsa052230.47409567
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.45156144
128AMPK signaling pathway_Homo sapiens_hsa041520.44428229
129Ras signaling pathway_Homo sapiens_hsa040140.44343494
130Fatty acid biosynthesis_Homo sapiens_hsa000610.42769145
131Glycerolipid metabolism_Homo sapiens_hsa005610.42591503
132Metabolic pathways_Homo sapiens_hsa011000.42137762
133Huntingtons disease_Homo sapiens_hsa050160.40522326
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39957966
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39268112
136Oocyte meiosis_Homo sapiens_hsa041140.38593408
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38173339
138Alcoholism_Homo sapiens_hsa050340.37688905
139Basal cell carcinoma_Homo sapiens_hsa052170.37197026
140Endocytosis_Homo sapiens_hsa041440.36925428
141Renal cell carcinoma_Homo sapiens_hsa052110.35558716
142Primary bile acid biosynthesis_Homo sapiens_hsa001200.35147684
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32267433
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.31109508
145Rap1 signaling pathway_Homo sapiens_hsa040150.30401909
146Wnt signaling pathway_Homo sapiens_hsa043100.29557032
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29546826
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29420941

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