TBC1D26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.14857521
2response to pheromone (GO:0019236)8.73587330
3chromosome condensation (GO:0030261)7.71855858
4microtubule depolymerization (GO:0007019)7.58264845
5sperm capacitation (GO:0048240)7.56739023
6single strand break repair (GO:0000012)7.55254441
7spermatid development (GO:0007286)7.51187759
8DNA packaging (GO:0006323)7.48166724
9spermatid nucleus differentiation (GO:0007289)7.37179360
10plasma membrane fusion (GO:0045026)7.03051059
11sperm-egg recognition (GO:0035036)6.77268766
12axonemal dynein complex assembly (GO:0070286)6.54290694
13protein polyglutamylation (GO:0018095)6.48267852
14binding of sperm to zona pellucida (GO:0007339)6.26592860
15multicellular organism reproduction (GO:0032504)6.22717980
16microtubule polymerization or depolymerization (GO:0031109)6.16274394
17calcium ion-dependent exocytosis (GO:0017156)6.03876009
18reproduction (GO:0000003)5.73703445
19rRNA methylation (GO:0031167)5.71466645
20protein targeting to Golgi (GO:0000042)5.66596999
21regulation of cilium movement (GO:0003352)5.54483882
22cell-cell recognition (GO:0009988)5.50185455
23establishment of protein localization to Golgi (GO:0072600)5.44960756
24negative regulation of inclusion body assembly (GO:0090084)5.41725573
25spermatogenesis (GO:0007283)5.35683810
26male gamete generation (GO:0048232)5.33752429
27retrograde transport, vesicle recycling within Golgi (GO:0000301)5.30930087
28sexual reproduction (GO:0019953)5.22584494
29phosphatidylethanolamine biosynthetic process (GO:0006646)5.16348153
30cilium or flagellum-dependent cell motility (GO:0001539)5.08103833
31centriole replication (GO:0007099)5.05216458
32epithelial cilium movement (GO:0003351)4.99243092
33rRNA modification (GO:0000154)4.95554836
34motile cilium assembly (GO:0044458)4.94952925
35cellular ketone body metabolic process (GO:0046950)4.91437289
36gamete generation (GO:0007276)4.90241961
37phosphatidylethanolamine metabolic process (GO:0046337)4.83184317
38microtubule severing (GO:0051013)4.80556500
39cell wall macromolecule metabolic process (GO:0044036)4.77545999
40cell wall macromolecule catabolic process (GO:0016998)4.48285424
41single fertilization (GO:0007338)4.45332165
42cilium movement (GO:0003341)4.38561078
43centriole assembly (GO:0098534)4.33969193
44ketone body metabolic process (GO:1902224)4.32815683
45protein localization to Golgi apparatus (GO:0034067)4.32242183
46germ cell development (GO:0007281)4.18398228
47chromatin silencing (GO:0006342)4.16399662
48regulation of transcription involved in cell fate commitment (GO:0060850)4.07004866
49* regulation of Rab GTPase activity (GO:0032313)3.99124247
50* positive regulation of Rab GTPase activity (GO:0032851)3.99124247
51RNA destabilization (GO:0050779)3.92399538
52regulation of microtubule-based movement (GO:0060632)3.92162345
53regulation of centriole replication (GO:0046599)3.90196212
54cellular process involved in reproduction in multicellular organism (GO:0022412)3.89262462
55regulation of inclusion body assembly (GO:0090083)3.87299087
56multicellular organismal reproductive process (GO:0048609)3.85956572
57coenzyme catabolic process (GO:0009109)3.82481168
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.81511088
59fertilization (GO:0009566)3.67670590
60nucleus organization (GO:0006997)3.64885618
61seminiferous tubule development (GO:0072520)3.60477820
62negative regulation of Rho protein signal transduction (GO:0035024)3.39196150
63organic cation transport (GO:0015695)3.34781279
64polyamine biosynthetic process (GO:0006596)3.25766097
65response to acidic pH (GO:0010447)3.25619345
66protein-DNA complex disassembly (GO:0032986)3.20978101
67nucleosome disassembly (GO:0006337)3.20978101
68cranial nerve morphogenesis (GO:0021602)3.19556140
69musculoskeletal movement (GO:0050881)3.18152149
70multicellular organismal movement (GO:0050879)3.18152149
71cerebral cortex neuron differentiation (GO:0021895)3.09289890
72histone H3-K9 demethylation (GO:0033169)3.03574554
73microtubule nucleation (GO:0007020)3.02561121
74detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.99619597
75cell recognition (GO:0008037)2.99522605
76negative regulation of gene expression, epigenetic (GO:0045814)2.98532774
77histone exchange (GO:0043486)2.95533895
78spinal cord motor neuron differentiation (GO:0021522)2.86115078
79peptidyl-threonine dephosphorylation (GO:0035970)2.86027878
80regulation of somitogenesis (GO:0014807)2.79319563
81glycerol ether metabolic process (GO:0006662)2.79276273
82cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.78442721
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.76862117
84multicellular organismal development (GO:0007275)2.76610510
85cilium organization (GO:0044782)2.75316095
86cilium assembly (GO:0042384)2.75054840
87cellular biogenic amine biosynthetic process (GO:0042401)2.73928618
88ether metabolic process (GO:0018904)2.73904781
89negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.72345033
90regulation of phosphoprotein phosphatase activity (GO:0043666)2.68455860
91cellular response to pH (GO:0071467)2.67007607
92somite rostral/caudal axis specification (GO:0032525)2.66028058
93male meiosis I (GO:0007141)2.65522009
94amine biosynthetic process (GO:0009309)2.63410925
95DNA methylation involved in gamete generation (GO:0043046)2.62914376
96male meiosis (GO:0007140)2.60035581
97regulation of interleukin-13 production (GO:0032656)2.59694134
98ventricular system development (GO:0021591)2.57347927
99acrosome reaction (GO:0007340)11.1244120
100sperm motility (GO:0030317)10.6021888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.01741188
2EZH2_22144423_ChIP-Seq_EOC_Human3.95242855
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.01119039
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.73534691
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.68812689
6FUS_26573619_Chip-Seq_HEK293_Human2.56651603
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.49654724
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.45453221
9TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45453221
10ZNF274_21170338_ChIP-Seq_K562_Hela2.40924513
11CBP_20019798_ChIP-Seq_JUKART_Human2.21818959
12IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.21818959
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08289296
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07992781
15TAF15_26573619_Chip-Seq_HEK293_Human1.95976611
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.91225968
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88103243
18ER_23166858_ChIP-Seq_MCF-7_Human1.84631299
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.83727620
20P300_19829295_ChIP-Seq_ESCs_Human1.81502924
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.81114613
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80563184
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.74086559
24GBX2_23144817_ChIP-Seq_PC3_Human1.67941737
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.66436108
26* ERA_21632823_ChIP-Seq_H3396_Human1.66424026
27AR_21572438_ChIP-Seq_LNCaP_Human1.65608113
28DROSHA_22980978_ChIP-Seq_HELA_Human1.63939951
29NANOG_20526341_ChIP-Seq_ESCs_Human1.61901031
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.61785842
31AR_25329375_ChIP-Seq_VCAP_Human1.59507023
32VDR_22108803_ChIP-Seq_LS180_Human1.58709652
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58365025
34VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.56802731
35EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.55424853
36RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.50387083
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47644859
38RAC3_21632823_ChIP-Seq_H3396_Human1.47578201
39AUTS2_25519132_ChIP-Seq_293T-REX_Human1.46838972
40SMAD4_21741376_ChIP-Seq_EPCs_Human1.46314845
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.45883285
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45316149
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.45010243
44MYC_19829295_ChIP-Seq_ESCs_Human1.44901014
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44155666
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42462826
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.41336014
48CTCF_27219007_Chip-Seq_Bcells_Human1.38712189
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.38349705
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36139356
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33906363
52SMAD4_21799915_ChIP-Seq_A2780_Human1.32395087
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.30325224
54RUNX2_22187159_ChIP-Seq_PCA_Human1.28816102
55TAF2_19829295_ChIP-Seq_ESCs_Human1.28390200
56SMAD3_21741376_ChIP-Seq_ESCs_Human1.27621750
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.27541683
58REST_21632747_ChIP-Seq_MESCs_Mouse1.26612395
59TP53_18474530_ChIP-ChIP_U2OS_Human1.25732031
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.24588266
61* OCT4_20526341_ChIP-Seq_ESCs_Human1.22944293
62NANOG_19829295_ChIP-Seq_ESCs_Human1.21953681
63SOX2_19829295_ChIP-Seq_ESCs_Human1.21953681
64IGF1R_20145208_ChIP-Seq_DFB_Human1.20138351
65CTCF_20526341_ChIP-Seq_ESCs_Human1.20031441
66TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18232875
67CBX2_22325352_ChIP-Seq_293T-Rex_Human1.16944831
68STAT3_23295773_ChIP-Seq_U87_Human1.16865951
69E2F1_20622854_ChIP-Seq_HELA_Human1.15789257
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.15114543
71TBL1_22424771_ChIP-Seq_293T_Human1.14827127
72HNFA_21074721_ChIP-Seq_CACO-2_Human1.14412235
73NFYB_21822215_ChIP-Seq_K562_Human1.13644828
74ETV1_20927104_ChIP-Seq_GIST48_Human1.13410280
75ERG_20517297_ChIP-Seq_VCAP_Human1.12566558
76PHF8_20622854_ChIP-Seq_HELA_Human1.12239053
77RBPJ_21746931_ChIP-Seq_IB4_Human1.11157098
78CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.11117009
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10531478
80BCL6_27268052_Chip-Seq_Bcells_Human1.09389285
81SMAD4_21741376_ChIP-Seq_HESCs_Human1.09283221
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08687412
83E2F1_17053090_ChIP-ChIP_MCF-7_Human1.08581005
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08039076
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.06541665
86JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05187478
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04849643
88SMC4_20622854_ChIP-Seq_HELA_Human1.03264989
89NCOR_22424771_ChIP-Seq_293T_Human1.03222049
90PHF8_20622853_ChIP-Seq_HELA_Human1.02525841
91P53_21459846_ChIP-Seq_SAOS-2_Human1.01669638
92RUNX1_26923725_Chip-Seq_HPCs_Mouse1.00989882
93NFYA_21822215_ChIP-Seq_K562_Human1.00656909
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99918370
95SOX2_22085726_ChIP-Seq_NPCs_Mouse0.98977026
96HOXB7_26014856_ChIP-Seq_BT474_Human0.98931321
97RNF2_27304074_Chip-Seq_NSC_Mouse0.97053542
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95884938
99EED_16625203_ChIP-ChIP_MESCs_Mouse0.95543729
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.93458404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.10928088
2MP0005377_hearing/vestibular/ear_phenot3.85353216
3MP0003878_abnormal_ear_physiology3.85353216
4MP0003698_abnormal_male_reproductive3.72133960
5MP0001929_abnormal_gametogenesis3.13532685
6MP0005670_abnormal_white_adipose2.96547632
7MP0002234_abnormal_pharynx_morphology2.29612686
8MP0001348_abnormal_lacrimal_gland2.16538322
9MP0003880_abnormal_central_pattern2.06316277
10MP0002161_abnormal_fertility/fecundity2.05850775
11MP0000678_abnormal_parathyroid_gland1.94578352
12MP0003718_maternal_effect1.92771681
13MP0005423_abnormal_somatic_nervous1.85531069
14MP0003646_muscle_fatigue1.83869889
15MP0004859_abnormal_synaptic_plasticity1.83429325
16MP0001486_abnormal_startle_reflex1.79848394
17MP0001968_abnormal_touch/_nociception1.78155279
18MP0006292_abnormal_olfactory_placode1.77534776
19MP0001485_abnormal_pinna_reflex1.74316016
20MP0005248_abnormal_Harderian_gland1.69473988
21MP0003011_delayed_dark_adaptation1.67277907
22MP0000049_abnormal_middle_ear1.63835934
23MP0002210_abnormal_sex_determination1.63581457
24MP0001529_abnormal_vocalization1.59849522
25MP0002653_abnormal_ependyma_morphology1.59056100
26MP0002735_abnormal_chemical_nociception1.49962971
27MP0002282_abnormal_trachea_morphology1.47062003
28MP0002132_abnormal_respiratory_system1.44136520
29MP0009053_abnormal_anal_canal1.43909018
30MP0002249_abnormal_larynx_morphology1.42759978
31MP0001145_abnormal_male_reproductive1.40569920
32MP0004742_abnormal_vestibular_system1.38165937
33MP0001984_abnormal_olfaction1.33775219
34MP0000653_abnormal_sex_gland1.32421154
35MP0000026_abnormal_inner_ear1.32089593
36MP0001963_abnormal_hearing_physiology1.31694237
37MP0005499_abnormal_olfactory_system1.31122703
38MP0005394_taste/olfaction_phenotype1.31122703
39MP0008789_abnormal_olfactory_epithelium1.30233452
40MP0003119_abnormal_digestive_system1.30215802
41MP0003136_yellow_coat_color1.28965965
42MP0000955_abnormal_spinal_cord1.27080326
43MP0005379_endocrine/exocrine_gland_phen1.26260735
44MP0009745_abnormal_behavioral_response1.24868443
45MP0002822_catalepsy1.21547855
46MP0008877_abnormal_DNA_methylation1.20872049
47MP0000516_abnormal_urinary_system1.19661720
48MP0005367_renal/urinary_system_phenotyp1.19661720
49MP0002557_abnormal_social/conspecific_i1.18379703
50MP0002272_abnormal_nervous_system1.18123402
51MP0008995_early_reproductive_senescence1.16112035
52MP0002736_abnormal_nociception_after1.16002841
53MP0002067_abnormal_sensory_capabilities1.15237796
54MP0000534_abnormal_ureter_morphology1.11734987
55MP0009046_muscle_twitch1.11368788
56MP0005551_abnormal_eye_electrophysiolog1.09985844
57MP0002572_abnormal_emotion/affect_behav1.09322710
58MP0005253_abnormal_eye_physiology1.08574902
59MP0006276_abnormal_autonomic_nervous1.07761011
60MP0000778_abnormal_nervous_system1.07245854
61MP0000566_synostosis1.06856175
62MP0003635_abnormal_synaptic_transmissio1.06747063
63MP0001293_anophthalmia1.04414842
64MP0002733_abnormal_thermal_nociception1.03163212
65MP0001905_abnormal_dopamine_level1.02047682
66MP0002734_abnormal_mechanical_nocicepti1.00925963
67MP0002102_abnormal_ear_morphology0.98383323
68MP0005645_abnormal_hypothalamus_physiol0.97642780
69MP0003122_maternal_imprinting0.97159046
70MP0002127_abnormal_cardiovascular_syste0.92908119
71MP0003315_abnormal_perineum_morphology0.91526830
72MP0009697_abnormal_copulation0.88585178
73MP0001970_abnormal_pain_threshold0.87320041
74MP0002229_neurodegeneration0.82772071
75MP0002064_seizures0.82058694
76MP0002184_abnormal_innervation0.81947989
77MP0003879_abnormal_hair_cell0.81568911
78MP0002063_abnormal_learning/memory/cond0.81005443
79MP0005187_abnormal_penis_morphology0.79096080
80MP0004085_abnormal_heartbeat0.78666741
81MP0002882_abnormal_neuron_morphology0.77963183
82MP0008569_lethality_at_weaning0.77347015
83MP0003861_abnormal_nervous_system0.76931783
84MP0004270_analgesia0.76683999
85MP0002752_abnormal_somatic_nervous0.76317701
86MP0005391_vision/eye_phenotype0.75045405
87MP0002938_white_spotting0.74886833
88MP0000631_abnormal_neuroendocrine_gland0.72866955
89MP0003942_abnormal_urinary_system0.71008508
90MP0003937_abnormal_limbs/digits/tail_de0.70282573
91MP0003938_abnormal_ear_development0.68895283
92MP0003385_abnormal_body_wall0.67239229
93MP0004811_abnormal_neuron_physiology0.65514705
94MP0001299_abnormal_eye_distance/0.65047946
95MP0003137_abnormal_impulse_conducting0.64639034
96MP0003283_abnormal_digestive_organ0.63877546
97MP0005167_abnormal_blood-brain_barrier0.63159383
98MP0001765_abnormal_ion_homeostasis0.61507272
99MP0005395_other_phenotype0.60620977
100MP0001501_abnormal_sleep_pattern0.60006367

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)6.07713032
2Absent/shortened dynein arms (HP:0200106)5.54474720
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.54474720
4Abnormal respiratory motile cilium physiology (HP:0012261)4.79466001
5Abnormal ciliary motility (HP:0012262)4.74889157
6Attenuation of retinal blood vessels (HP:0007843)4.59388426
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.55291098
8Abnormal respiratory motile cilium morphology (HP:0005938)4.50373416
9Abnormal respiratory epithelium morphology (HP:0012253)4.50373416
10Bony spicule pigmentary retinopathy (HP:0007737)4.33916568
11Chronic hepatic failure (HP:0100626)4.04491410
12Tubulointerstitial nephritis (HP:0001970)3.98937372
13Abnormal rod and cone electroretinograms (HP:0008323)3.68023152
14Abnormality of macular pigmentation (HP:0008002)3.65581290
15Infertility (HP:0000789)3.54385293
16Nephronophthisis (HP:0000090)3.37087923
17Bell-shaped thorax (HP:0001591)3.31611722
18Hypoplastic ischia (HP:0003175)3.24243937
19Rhinitis (HP:0012384)3.14568800
20Resting tremor (HP:0002322)3.12049957
21Hyperkalemia (HP:0002153)2.94527354
22Male infertility (HP:0003251)2.93670332
23Optic nerve hypoplasia (HP:0000609)2.92166100
24Abnormality of the renal medulla (HP:0100957)2.88116880
25Pancreatic fibrosis (HP:0100732)2.87786555
26Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.86754635
27Abnormality of the ischium (HP:0003174)2.85251326
28Impulsivity (HP:0100710)2.80312828
29Asymmetric septal hypertrophy (HP:0001670)2.80041389
30Facial shape deformation (HP:0011334)2.78982801
31Potter facies (HP:0002009)2.78982801
32Progressive cerebellar ataxia (HP:0002073)2.77050381
33Renal dysplasia (HP:0000110)2.72005465
34Nasal polyposis (HP:0100582)2.61105542
35Pancreatic cysts (HP:0001737)2.59719310
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.59692079
37Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.52745714
38Unilateral renal agenesis (HP:0000122)2.52261130
39True hermaphroditism (HP:0010459)2.50194197
40Occipital encephalocele (HP:0002085)2.49141943
41Enlarged epiphyses (HP:0010580)2.43568225
42Azoospermia (HP:0000027)2.43319346
43Postural instability (HP:0002172)2.42974575
44Abnormal spermatogenesis (HP:0008669)2.42535105
45Aplasia/Hypoplasia of the earlobes (HP:0009906)2.41379698
46Retinal dysplasia (HP:0007973)2.39879522
47Myokymia (HP:0002411)2.39744804
48Abnormality of the aortic arch (HP:0012303)2.38772213
49Abnormal urine output (HP:0012590)2.36995376
50Tubulointerstitial abnormality (HP:0001969)2.28158437
51Midline defect of the nose (HP:0004122)2.28076163
52Anophthalmia (HP:0000528)2.25456232
53Sclerocornea (HP:0000647)2.17874977
54Stage 5 chronic kidney disease (HP:0003774)2.15279092
55Chronic bronchitis (HP:0004469)2.14394156
56Abnormal drinking behavior (HP:0030082)2.13875813
57Polydipsia (HP:0001959)2.13875813
58Cone-rod dystrophy (HP:0000548)2.13014468
59Polyuria (HP:0000103)2.12684752
60Type II lissencephaly (HP:0007260)2.11642026
61Pendular nystagmus (HP:0012043)2.11197689
62Abnormality of renal excretion (HP:0011036)2.11013411
63Cystic liver disease (HP:0006706)2.09809792
64Absent epiphyses (HP:0010577)2.09060955
65Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.09060955
66Anencephaly (HP:0002323)2.05022377
67Congenital malformation of the right heart (HP:0011723)2.03726888
68Double outlet right ventricle (HP:0001719)2.03726888
69Cerebellar dysplasia (HP:0007033)2.02319626
70Abnormality of the pubic bones (HP:0003172)2.00614340
71Amblyopia (HP:0000646)1.98540510
72Decreased central vision (HP:0007663)1.98302535
73Generalized aminoaciduria (HP:0002909)1.96435103
74Bronchiectasis (HP:0002110)1.94068514
75Abnormality of potassium homeostasis (HP:0011042)1.87960774
76Hypoplasia of the thymus (HP:0000778)1.87468210
77Genital tract atresia (HP:0001827)1.85147634
78Abnormality of the nasal mucosa (HP:0000433)1.84532500
79Intellectual disability, moderate (HP:0002342)1.83887554
80Sensory axonal neuropathy (HP:0003390)1.82928656
81Flat capital femoral epiphysis (HP:0003370)1.81328848
82Vaginal atresia (HP:0000148)1.75827620
83Renovascular hypertension (HP:0100817)1.73071042
84Postaxial foot polydactyly (HP:0001830)1.73045647
85Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.72164835
86Abnormality of midbrain morphology (HP:0002418)1.71751781
87Molar tooth sign on MRI (HP:0002419)1.71751781
88Renal Fanconi syndrome (HP:0001994)1.70581623
89Gait imbalance (HP:0002141)1.69274949
90Progressive sensorineural hearing impairment (HP:0000408)1.68356856
91Hypoplasia of the brainstem (HP:0002365)1.66542938
92Aplasia/Hypoplasia of the brainstem (HP:0007362)1.66542938
93Truncal obesity (HP:0001956)1.65987615
94Medial flaring of the eyebrow (HP:0010747)1.63428334
95Poor coordination (HP:0002370)1.62485108
96Congenital primary aphakia (HP:0007707)1.61488848
97Tubular atrophy (HP:0000092)1.60794549
98Growth hormone deficiency (HP:0000824)1.60611889
99Neoplasm of the heart (HP:0100544)1.59271742
100Abnormality of the epiphysis of the femoral head (HP:0010574)1.58459705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.71920676
2TESK14.23529338
3DDR23.74381637
4MAP4K23.71897526
5INSRR3.31767139
6PLK22.92723063
7PRKD32.71854703
8BRD42.62742032
9STK382.59289171
10MAPK152.51683296
11PNCK2.29102870
12STK38L2.17343938
13MAP3K42.02744814
14MAP2K71.94376976
15MARK11.73011281
16CAMK1G1.72769120
17DYRK1B1.63705704
18PINK11.62697409
19EPHA41.48282052
20DYRK21.34334594
21PTK2B1.27948031
22CDK191.20860254
23WNK11.20666783
24DYRK31.13752672
25BMPR1B1.12003178
26ZAK1.07001722
27FRK1.04527645
28UHMK11.02573949
29CASK1.02565553
30VRK10.98419661
31NTRK30.97293047
32TYRO30.97183166
33MAPK130.95699701
34PDK10.94642862
35PIK3CG0.93927558
36PDPK10.92370179
37WNK30.90984692
38MAP3K90.86794875
39SGK4940.86104661
40SGK2230.86104661
41CDK70.86009756
42SIK20.85596011
43CAMK10.85455466
44LATS20.81795165
45PRKCG0.80550024
46WNK40.78797315
47ADRBK20.77242654
48CDK30.76344851
49CAMK1D0.73892902
50NUAK10.71129559
51PKN10.69500080
52PRKG10.68861934
53NEK60.67725094
54LATS10.66632604
55MINK10.66170157
56TRIM280.62815567
57CSNK1G20.62108082
58NTRK20.61061983
59CSNK1G30.60675936
60TNIK0.59337595
61CAMK40.58335302
62MET0.56124362
63NME10.55441155
64NEK20.54864522
65CSNK1G10.54456944
66AKT30.53611634
67PRKG20.51922919
68ROCK10.51825125
69MST1R0.50161654
70CSNK1A1L0.48313238
71RPS6KA10.46269670
72GSK3B0.45836607
73OXSR10.44527516
74CDK20.43127708
75CDK10.41117068
76RPS6KA20.39204044
77PAK30.38870190
78PRKCZ0.38382652
79MKNK10.33873943
80SGK10.33643147
81MAPK10.32476599
82MAPK80.32289056
83PRKCE0.31301460
84PRKAA20.30875355
85EPHB20.30146154
86PRKACA0.29992978
87SRPK10.29809376
88MUSK0.29579040
89CAMK2A0.29547708
90TESK20.29545921
91TIE10.28904317
92CDK50.28820191
93CHEK10.28292228
94OBSCN0.27882414
95PRKCB0.27216326
96TAF10.27082858
97MAP2K40.26953777
98PRKACB0.26565310
99ERBB30.26511906
100BCR0.24826228

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.26931670
2Fatty acid biosynthesis_Homo sapiens_hsa000614.18108428
3Olfactory transduction_Homo sapiens_hsa047403.97865107
4Butanoate metabolism_Homo sapiens_hsa006503.12528282
5Taste transduction_Homo sapiens_hsa047422.55993353
6Nicotine addiction_Homo sapiens_hsa050332.38714977
7Phototransduction_Homo sapiens_hsa047441.92692354
8RNA transport_Homo sapiens_hsa030131.72260977
9Hedgehog signaling pathway_Homo sapiens_hsa043401.68448748
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63389243
11Cardiac muscle contraction_Homo sapiens_hsa042601.58466965
12Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.49233316
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46266771
14Synaptic vesicle cycle_Homo sapiens_hsa047211.42125832
15Huntingtons disease_Homo sapiens_hsa050161.35798871
16Basal transcription factors_Homo sapiens_hsa030221.35667107
17Morphine addiction_Homo sapiens_hsa050321.33856228
18GABAergic synapse_Homo sapiens_hsa047271.30448251
19Type II diabetes mellitus_Homo sapiens_hsa049301.29130560
20Glycerophospholipid metabolism_Homo sapiens_hsa005641.29025096
21Circadian entrainment_Homo sapiens_hsa047131.28332044
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28156531
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25535668
24Glutamatergic synapse_Homo sapiens_hsa047241.22831673
25Arginine and proline metabolism_Homo sapiens_hsa003301.21802052
26Phenylalanine metabolism_Homo sapiens_hsa003601.17739848
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13339027
28Fatty acid metabolism_Homo sapiens_hsa012121.10912579
29Selenocompound metabolism_Homo sapiens_hsa004501.10022779
30Fanconi anemia pathway_Homo sapiens_hsa034601.05218016
31Fatty acid degradation_Homo sapiens_hsa000711.04951411
32Salivary secretion_Homo sapiens_hsa049700.99586218
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99172106
34Oocyte meiosis_Homo sapiens_hsa041140.97986551
35Nitrogen metabolism_Homo sapiens_hsa009100.97120743
36Calcium signaling pathway_Homo sapiens_hsa040200.95888279
37Dorso-ventral axis formation_Homo sapiens_hsa043200.95091357
38Basal cell carcinoma_Homo sapiens_hsa052170.93942732
39Alcoholism_Homo sapiens_hsa050340.90458033
40Purine metabolism_Homo sapiens_hsa002300.89456698
41Arginine biosynthesis_Homo sapiens_hsa002200.86795373
42Oxidative phosphorylation_Homo sapiens_hsa001900.83717854
43Propanoate metabolism_Homo sapiens_hsa006400.83432221
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77825229
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76651933
46Type I diabetes mellitus_Homo sapiens_hsa049400.75625246
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75253340
48Autoimmune thyroid disease_Homo sapiens_hsa053200.75158103
49Retinol metabolism_Homo sapiens_hsa008300.74123399
50cAMP signaling pathway_Homo sapiens_hsa040240.73511180
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68192066
52mRNA surveillance pathway_Homo sapiens_hsa030150.67686609
53Spliceosome_Homo sapiens_hsa030400.66599297
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.66541812
55ABC transporters_Homo sapiens_hsa020100.64752752
56Insulin secretion_Homo sapiens_hsa049110.63510589
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62756478
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62405333
59Protein digestion and absorption_Homo sapiens_hsa049740.60532557
60Linoleic acid metabolism_Homo sapiens_hsa005910.59811246
61Glycerolipid metabolism_Homo sapiens_hsa005610.58154730
62Parkinsons disease_Homo sapiens_hsa050120.57922634
63Antigen processing and presentation_Homo sapiens_hsa046120.57882626
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57854368
65Serotonergic synapse_Homo sapiens_hsa047260.57680156
66Cholinergic synapse_Homo sapiens_hsa047250.57621127
67Tight junction_Homo sapiens_hsa045300.55992578
68Allograft rejection_Homo sapiens_hsa053300.55410750
69Tyrosine metabolism_Homo sapiens_hsa003500.54916154
70Base excision repair_Homo sapiens_hsa034100.52900075
71Fat digestion and absorption_Homo sapiens_hsa049750.52694452
72Tryptophan metabolism_Homo sapiens_hsa003800.51735521
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51585515
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51413052
75Homologous recombination_Homo sapiens_hsa034400.50416266
76Gastric acid secretion_Homo sapiens_hsa049710.50219665
77RNA polymerase_Homo sapiens_hsa030200.49104677
78RNA degradation_Homo sapiens_hsa030180.48280473
79beta-Alanine metabolism_Homo sapiens_hsa004100.47488154
80Biosynthesis of amino acids_Homo sapiens_hsa012300.46328234
81Hippo signaling pathway_Homo sapiens_hsa043900.45800107
82Long-term depression_Homo sapiens_hsa047300.44980748
83Metabolic pathways_Homo sapiens_hsa011000.44788102
84PPAR signaling pathway_Homo sapiens_hsa033200.44121014
85Graft-versus-host disease_Homo sapiens_hsa053320.43482642
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.42390345
87Axon guidance_Homo sapiens_hsa043600.42153548
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41176152
89Systemic lupus erythematosus_Homo sapiens_hsa053220.40186947
90Peroxisome_Homo sapiens_hsa041460.40164106
91Regulation of autophagy_Homo sapiens_hsa041400.40083848
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38282378
93Gap junction_Homo sapiens_hsa045400.35757667
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.35710967
95Cocaine addiction_Homo sapiens_hsa050300.35433504
96Amphetamine addiction_Homo sapiens_hsa050310.35336785
97Oxytocin signaling pathway_Homo sapiens_hsa049210.35212188
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33958761
99Dopaminergic synapse_Homo sapiens_hsa047280.32901889
100Chemical carcinogenesis_Homo sapiens_hsa052040.31745306

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