TBC1D27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.44901621
2regulation of B cell receptor signaling pathway (GO:0050855)4.95386149
3B cell receptor signaling pathway (GO:0050853)4.69697285
4T cell migration (GO:0072678)4.40709377
5DNA deamination (GO:0045006)4.07495353
6B cell homeostasis (GO:0001782)4.06219247
7cytidine deamination (GO:0009972)4.04058674
8cytidine metabolic process (GO:0046087)4.04058674
9cytidine catabolic process (GO:0006216)4.04058674
10NIK/NF-kappaB signaling (GO:0038061)3.91073704
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.83136764
12positive regulation of gamma-delta T cell activation (GO:0046645)3.80973985
13positive regulation of defense response to virus by host (GO:0002230)3.78904575
14regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.72073041
15regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.65763582
16pyrimidine ribonucleoside catabolic process (GO:0046133)3.61149620
17T cell lineage commitment (GO:0002360)3.50585657
18positive regulation of protein homodimerization activity (GO:0090073)3.40044971
19interferon-gamma production (GO:0032609)3.37957495
20negative thymic T cell selection (GO:0045060)3.33936943
21regulation of alpha-beta T cell proliferation (GO:0046640)3.31938442
22negative regulation of calcium ion transport into cytosol (GO:0010523)3.24412923
23behavioral response to nicotine (GO:0035095)3.23597876
24negative T cell selection (GO:0043383)3.22442052
25regulation of B cell differentiation (GO:0045577)3.18912911
26somatic diversification of immune receptors via somatic mutation (GO:0002566)3.12209895
27somatic hypermutation of immunoglobulin genes (GO:0016446)3.12209895
28interferon-gamma-mediated signaling pathway (GO:0060333)3.10127093
29positive regulation of humoral immune response (GO:0002922)3.08592185
30negative regulation of B cell proliferation (GO:0030889)3.08326853
31regulation of defense response to virus by host (GO:0050691)3.05106762
32fucose catabolic process (GO:0019317)3.03185629
33L-fucose metabolic process (GO:0042354)3.03185629
34L-fucose catabolic process (GO:0042355)3.03185629
35regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.99140197
36antigen processing and presentation of endogenous antigen (GO:0019883)2.98721998
37positive regulation of alpha-beta T cell proliferation (GO:0046641)2.98682750
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98558151
39DNA demethylation (GO:0080111)2.97688245
40response to type I interferon (GO:0034340)2.95202884
41regulation of gamma-delta T cell activation (GO:0046643)2.93288690
42antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.90181639
43regulation of antigen processing and presentation (GO:0002577)2.90013199
44positive regulation of protein homooligomerization (GO:0032464)2.88380639
45positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.88236037
46cellular response to type I interferon (GO:0071357)2.88102715
47type I interferon signaling pathway (GO:0060337)2.88102715
48immunoglobulin mediated immune response (GO:0016064)2.86471331
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84964911
50endoderm formation (GO:0001706)2.83868213
51negative regulation of mast cell activation (GO:0033004)2.81674823
52positive regulation of T-helper 1 type immune response (GO:0002827)2.79709730
53neural tube formation (GO:0001841)2.79572752
54positive regulation of antigen processing and presentation (GO:0002579)2.79433177
55positive regulation of interferon-alpha production (GO:0032727)2.78023251
56regulation of B cell proliferation (GO:0030888)2.77127202
57B cell proliferation (GO:0042100)2.75853269
58cellular response to interleukin-15 (GO:0071350)2.74539159
59response to pheromone (GO:0019236)2.74136741
60positive regulation of interleukin-2 production (GO:0032743)2.73575375
61negative regulation of telomere maintenance (GO:0032205)2.70947660
62mast cell activation (GO:0045576)2.70223257
63defense response to protozoan (GO:0042832)2.69480274
64regulation of interferon-alpha production (GO:0032647)2.68412973
65cellular response to exogenous dsRNA (GO:0071360)2.65860621
66regulation of interferon-gamma biosynthetic process (GO:0045072)2.65841027
67protein K11-linked deubiquitination (GO:0035871)2.65350261
68lymphocyte homeostasis (GO:0002260)2.64718171
69indolalkylamine metabolic process (GO:0006586)2.63244627
70antigen receptor-mediated signaling pathway (GO:0050851)2.60913412
71positive regulation of immunoglobulin mediated immune response (GO:0002891)2.60602709
72positive regulation of B cell mediated immunity (GO:0002714)2.60602709
73lymphocyte migration (GO:0072676)2.60583747
74positive regulation of B cell differentiation (GO:0045579)2.57057168
75regulation of interferon-beta biosynthetic process (GO:0045357)2.56225459
76negative regulation of alpha-beta T cell activation (GO:0046636)2.54865184
77germinal center formation (GO:0002467)2.54826540
78T cell costimulation (GO:0031295)2.54496249
79mast cell activation involved in immune response (GO:0002279)2.53573100
80mast cell degranulation (GO:0043303)2.53573100
81respiratory chain complex IV assembly (GO:0008535)2.53475891
82regulation of germinal center formation (GO:0002634)2.52903639
83response to protozoan (GO:0001562)2.52393360
84regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.51271568
85lymphocyte costimulation (GO:0031294)2.50854395
86regulation of dendritic cell antigen processing and presentation (GO:0002604)2.48829817
87detection of light stimulus involved in sensory perception (GO:0050962)2.46581171
88detection of light stimulus involved in visual perception (GO:0050908)2.46581171
89modulation by symbiont of host defense response (GO:0052031)2.46391890
90modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.46391890
91modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.46391890
92positive regulation by organism of defense response of other organism involved in symbiotic interact2.46391890
93modulation by symbiont of host immune response (GO:0052553)2.46391890
94positive regulation by symbiont of host defense response (GO:0052509)2.46391890
95purinergic nucleotide receptor signaling pathway (GO:0035590)2.45878820
96cellular ketone body metabolic process (GO:0046950)2.45109908
97thymic T cell selection (GO:0045061)2.45064616
98indole-containing compound catabolic process (GO:0042436)2.43930631
99indolalkylamine catabolic process (GO:0046218)2.43930631
100tryptophan catabolic process (GO:0006569)2.43930631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.22070886
2NOTCH1_21737748_ChIP-Seq_TLL_Human4.08708749
3ZNF274_21170338_ChIP-Seq_K562_Hela3.57725999
4EZH2_22144423_ChIP-Seq_EOC_Human3.11606529
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93441300
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.78286446
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76775446
8CIITA_25753668_ChIP-Seq_RAJI_Human2.45558449
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24022481
10VDR_22108803_ChIP-Seq_LS180_Human2.22713663
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.15441860
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.14190074
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.13888163
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.08485870
15VDR_23849224_ChIP-Seq_CD4+_Human2.08290122
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.06993544
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03243405
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.02086885
19MYC_22102868_ChIP-Seq_BL_Human1.97777591
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96555922
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95702038
22MYB_26560356_Chip-Seq_TH2_Human1.93907768
23IRF1_19129219_ChIP-ChIP_H3396_Human1.80964249
24GATA3_26560356_Chip-Seq_TH2_Human1.79925771
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75607406
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72887216
27MYB_26560356_Chip-Seq_TH1_Human1.66577900
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64024466
29RUNX_20019798_ChIP-Seq_JUKART_Human1.63826720
30FOXP3_21729870_ChIP-Seq_TREG_Human1.63745393
31GATA3_27048872_Chip-Seq_THYMUS_Human1.54452468
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54290537
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.48226803
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43994379
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42245850
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41439316
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40372858
38NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.39951537
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39618214
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36503129
41MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30427589
42EWS_26573619_Chip-Seq_HEK293_Human1.29803278
43MYC_18940864_ChIP-ChIP_HL60_Human1.28534283
44FUS_26573619_Chip-Seq_HEK293_Human1.28003938
45TP53_22573176_ChIP-Seq_HFKS_Human1.27126223
46SMRT_27268052_Chip-Seq_Bcells_Human1.26340423
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26334066
48ER_23166858_ChIP-Seq_MCF-7_Human1.25766110
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24087003
50EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23873276
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18313912
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18191259
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17370422
54GATA3_26560356_Chip-Seq_TH1_Human1.17097301
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.17045092
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16797301
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16797301
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.15008290
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15008290
60IGF1R_20145208_ChIP-Seq_DFB_Human1.14891796
61SPI1_23547873_ChIP-Seq_NB4_Human1.14612367
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14498362
63GBX2_23144817_ChIP-Seq_PC3_Human1.11905193
64FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11837757
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.11786370
66ELK1_19687146_ChIP-ChIP_HELA_Human1.11564600
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07943852
68PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07883391
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07004787
70HOXB7_26014856_ChIP-Seq_BT474_Human1.05087700
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.04809600
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04586403
73MYC_19829295_ChIP-Seq_ESCs_Human1.03368445
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.03180238
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.01925872
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00928760
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00539593
78NCOR_22424771_ChIP-Seq_293T_Human1.00512565
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99293189
80BCAT_22108803_ChIP-Seq_LS180_Human0.99067138
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97137229
82CBP_20019798_ChIP-Seq_JUKART_Human0.97137229
83MAF_26560356_Chip-Seq_TH1_Human0.96685461
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96003017
85SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95637062
86FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94523444
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93193240
88MAF_26560356_Chip-Seq_TH2_Human0.93106652
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91845793
90STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.91677440
91STAT3_23295773_ChIP-Seq_U87_Human0.90695934
92RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90109030
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89877106
94TCF4_23295773_ChIP-Seq_U87_Human0.89733929
95NANOG_20526341_ChIP-Seq_ESCs_Human0.89674055
96TAF15_26573619_Chip-Seq_HEK293_Human0.89473811
97YY1_21170310_ChIP-Seq_MESCs_Mouse0.88133598
98SOX2_19829295_ChIP-Seq_ESCs_Human0.87580499
99NANOG_19829295_ChIP-Seq_ESCs_Human0.87580499
100AR_21572438_ChIP-Seq_LNCaP_Human0.87200775

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system3.89696203
2MP0005671_abnormal_response_to3.58795203
3MP0001835_abnormal_antigen_presentation3.30417220
4MP0001790_abnormal_immune_system3.22148800
5MP0005387_immune_system_phenotype3.22148800
6MP0001800_abnormal_humoral_immune3.19158431
7MP0005645_abnormal_hypothalamus_physiol2.62591002
8MP0002138_abnormal_hepatobiliary_system2.59350845
9MP0008877_abnormal_DNA_methylation2.45292523
10MP0000372_irregular_coat_pigmentation2.29919802
11MP0005000_abnormal_immune_tolerance2.29244636
12MP0002723_abnormal_immune_serum2.28247006
13MP0002452_abnormal_antigen_presenting2.26829232
14MP0002163_abnormal_gland_morphology2.18654172
15MP0003763_abnormal_thymus_physiology2.06789551
16MP0002420_abnormal_adaptive_immunity2.05792047
17MP0001819_abnormal_immune_cell2.02620362
18MP0008057_abnormal_DNA_replication1.82910941
19MP0008872_abnormal_physiological_respon1.76990882
20MP0001986_abnormal_taste_sensitivity1.76519673
21MP0002398_abnormal_bone_marrow1.75604946
22MP0000716_abnormal_immune_system1.73716679
23MP0005310_abnormal_salivary_gland1.67912236
24MP0005075_abnormal_melanosome_morpholog1.66135972
25MP0000689_abnormal_spleen_morphology1.62125609
26MP0002166_altered_tumor_susceptibility1.54872667
27MP0003787_abnormal_imprinting1.49738686
28MP0009785_altered_susceptibility_to1.48267074
29MP0005551_abnormal_eye_electrophysiolog1.48144615
30MP0005379_endocrine/exocrine_gland_phen1.48077862
31MP0002638_abnormal_pupillary_reflex1.46376318
32MP0005025_abnormal_response_to1.46282585
33MP0003646_muscle_fatigue1.41836520
34MP0002102_abnormal_ear_morphology1.40421394
35MP0002928_abnormal_bile_duct1.37582622
36MP0002429_abnormal_blood_cell1.34578223
37MP0003436_decreased_susceptibility_to1.32003802
38MP0002148_abnormal_hypersensitivity_rea1.30797102
39MP0010094_abnormal_chromosome_stability1.30293806
40MP0009046_muscle_twitch1.28954608
41MP0009333_abnormal_splenocyte_physiolog1.27180366
42MP0001873_stomach_inflammation1.27087443
43MP0004043_abnormal_pH_regulation1.26709464
44MP0000569_abnormal_digit_pigmentation1.26484170
45MP0002006_tumorigenesis1.26311769
46MP0002722_abnormal_immune_system1.25788082
47MP0005423_abnormal_somatic_nervous1.25767951
48MP0008995_early_reproductive_senescence1.24988426
49MP0001845_abnormal_inflammatory_respons1.20120121
50MP0002693_abnormal_pancreas_physiology1.19627395
51MP0003183_abnormal_peptide_metabolism1.17633070
52MP0001968_abnormal_touch/_nociception1.17495734
53MP0004142_abnormal_muscle_tone1.14001878
54MP0003880_abnormal_central_pattern1.13857743
55MP0004381_abnormal_hair_follicle1.11724280
56MP0008058_abnormal_DNA_repair1.07457362
57MP0002653_abnormal_ependyma_morphology1.06369865
58MP0003045_fibrosis1.05089989
59MP0002419_abnormal_innate_immunity1.04423344
60MP0002405_respiratory_system_inflammati1.01998114
61MP0005499_abnormal_olfactory_system1.01845666
62MP0005394_taste/olfaction_phenotype1.01845666
63MP0003303_peritoneal_inflammation1.01378832
64MP0006072_abnormal_retinal_apoptosis1.00872442
65MP0000703_abnormal_thymus_morphology1.00359381
66MP0010155_abnormal_intestine_physiology0.96598627
67MP0005253_abnormal_eye_physiology0.93991105
68MP0009745_abnormal_behavioral_response0.93617764
69MP0001501_abnormal_sleep_pattern0.93099718
70MP0004145_abnormal_muscle_electrophysio0.92191904
71MP0003195_calcinosis0.90922568
72MP0009764_decreased_sensitivity_to0.88525082
73MP0001919_abnormal_reproductive_system0.86105502
74MP0001348_abnormal_lacrimal_gland0.84642300
75MP0006292_abnormal_olfactory_placode0.83367551
76MP0005220_abnormal_exocrine_pancreas0.81693449
77MP0002272_abnormal_nervous_system0.81143859
78MP0001984_abnormal_olfaction0.79933159
79MP0002396_abnormal_hematopoietic_system0.79288189
80MP0005386_behavior/neurological_phenoty0.78578413
81MP0004924_abnormal_behavior0.78578413
82MP0003252_abnormal_bile_duct0.77773858
83MP0000015_abnormal_ear_pigmentation0.77020689
84MP0003786_premature_aging0.76994538
85MP0003866_abnormal_defecation0.76438332
86MP0002876_abnormal_thyroid_physiology0.75177992
87MP0005410_abnormal_fertilization0.73448641
88MP0002735_abnormal_chemical_nociception0.73187949
89MP0002736_abnormal_nociception_after0.72834759
90MP0005389_reproductive_system_phenotype0.72632540
91MP0001529_abnormal_vocalization0.72474040
92MP0005084_abnormal_gallbladder_morpholo0.72013823
93MP0002933_joint_inflammation0.71089352
94MP0008789_abnormal_olfactory_epithelium0.69928786
95MP0002095_abnormal_skin_pigmentation0.68974993
96MP0006035_abnormal_mitochondrial_morpho0.68285886
97MP0002019_abnormal_tumor_incidence0.67754516
98MP0000371_diluted_coat_color0.67241836
99MP0006036_abnormal_mitochondrial_physio0.64915262
100MP0002067_abnormal_sensory_capabilities0.64397202

Predicted human phenotypes

RankGene SetZ-score
1Recurrent sinusitis (HP:0011108)4.61649658
2Gastrointestinal stroma tumor (HP:0100723)4.61483596
3Agammaglobulinemia (HP:0004432)4.35856892
4Abnormal delayed hypersensitivity skin test (HP:0002963)3.98937843
5Panhypogammaglobulinemia (HP:0003139)3.94253142
6IgG deficiency (HP:0004315)3.80562250
7IgA deficiency (HP:0002720)3.60129490
8Recurrent bronchitis (HP:0002837)3.49982217
9IgM deficiency (HP:0002850)3.39080726
10Abnormality of T cell physiology (HP:0011840)3.31287844
11Lymphopenia (HP:0001888)3.27354114
12Pancreatic cysts (HP:0001737)3.11364231
13Abnormality of cells of the lymphoid lineage (HP:0012140)3.05205900
14Chronic hepatic failure (HP:0100626)2.96301100
15Meningitis (HP:0001287)2.92349497
16Congenital stationary night blindness (HP:0007642)2.92285959
17Vasculitis (HP:0002633)2.86938215
18Recurrent cutaneous fungal infections (HP:0011370)2.81256285
19Chronic mucocutaneous candidiasis (HP:0002728)2.81256285
20Abnormality of B cell number (HP:0010975)2.76360547
21Recurrent viral infections (HP:0004429)2.73286219
22True hermaphroditism (HP:0010459)2.72833633
23Molar tooth sign on MRI (HP:0002419)2.68958073
24Abnormality of midbrain morphology (HP:0002418)2.68958073
25Attenuation of retinal blood vessels (HP:0007843)2.57417018
26Bronchitis (HP:0012387)2.52447033
27Pancreatic fibrosis (HP:0100732)2.48820548
28Decreased circulating renin level (HP:0003351)2.48491758
29Abnormality of T cells (HP:0002843)2.47074744
30Recurrent fungal infections (HP:0002841)2.42322901
31Chronic diarrhea (HP:0002028)2.36655269
32Nephronophthisis (HP:0000090)2.36639274
33Progressive inability to walk (HP:0002505)2.35501801
34Mediastinal lymphadenopathy (HP:0100721)2.34976564
35Emphysema (HP:0002097)2.34212055
36Abnormality of the renal cortex (HP:0011035)2.33858336
37Encephalitis (HP:0002383)2.29613605
38Inability to walk (HP:0002540)2.28053411
39Colitis (HP:0002583)2.26368678
40Stomach cancer (HP:0012126)2.26201929
41Recurrent lower respiratory tract infections (HP:0002783)2.23598670
42Tubular atrophy (HP:0000092)2.22011682
43Bronchiectasis (HP:0002110)2.21452722
44Type II lissencephaly (HP:0007260)2.20968793
45Recurrent pneumonia (HP:0006532)2.18186256
46Abnormal biliary tract physiology (HP:0012439)2.15638648
47Bile duct proliferation (HP:0001408)2.15638648
48B lymphocytopenia (HP:0010976)2.14653053
49Basal cell carcinoma (HP:0002671)2.14626641
50Abnormal drinking behavior (HP:0030082)2.14469971
51Polydipsia (HP:0001959)2.14469971
52Abnormal rod and cone electroretinograms (HP:0008323)2.10351016
53Chronic otitis media (HP:0000389)2.09408101
54Aplasia/Hypoplasia of the spleen (HP:0010451)2.06564278
55Conical tooth (HP:0000698)2.03734648
56Renal cortical cysts (HP:0000803)2.03325998
57Pulmonary infiltrates (HP:0002113)2.02429309
58Abnormality of the prostate (HP:0008775)2.00805396
59Lymphoma (HP:0002665)1.98187954
60Abnormality of the renal medulla (HP:0100957)1.97603924
61Increased IgM level (HP:0003496)1.95377314
62Medial flaring of the eyebrow (HP:0010747)1.94626593
63Hypokalemic alkalosis (HP:0001949)1.94142506
643-Methylglutaconic aciduria (HP:0003535)1.93491298
65Asplenia (HP:0001746)1.93187431
66Chronic sinusitis (HP:0011109)1.92065794
67Retrobulbar optic neuritis (HP:0100654)1.91474337
68Optic neuritis (HP:0100653)1.91474337
69Neutropenia (HP:0001875)1.90695897
70Squamous cell carcinoma (HP:0002860)1.89279523
71Inflammation of the large intestine (HP:0002037)1.88864355
72Restrictive lung disease (HP:0002091)1.88287310
73Pendular nystagmus (HP:0012043)1.86960657
74Protruding tongue (HP:0010808)1.86512612
75Lissencephaly (HP:0001339)1.85710298
76Abolished electroretinogram (ERG) (HP:0000550)1.84242411
77Large for gestational age (HP:0001520)1.83734877
78Clumsiness (HP:0002312)1.83394164
79Papilloma (HP:0012740)1.82857100
80Verrucae (HP:0200043)1.82857100
81Leukopenia (HP:0001882)1.80452387
82Gaze-evoked nystagmus (HP:0000640)1.79580165
83Cystic liver disease (HP:0006706)1.74403747
84Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73956215
85Bony spicule pigmentary retinopathy (HP:0007737)1.72706420
86Aplasia/Hypoplasia of the fovea (HP:0008060)1.72533597
87Hypoplasia of the fovea (HP:0007750)1.72533597
88Hypoalbuminemia (HP:0003073)1.71749205
89Abnormal albumin level (HP:0012116)1.71749205
90Pustule (HP:0200039)1.70028636
91Gastrointestinal inflammation (HP:0004386)1.68618442
92Methylmalonic aciduria (HP:0012120)1.65184129
93Hyperglycinuria (HP:0003108)1.65128344
94Clubbing of toes (HP:0100760)1.64838708
95Optic disc pallor (HP:0000543)1.64621335
96Progressive microcephaly (HP:0000253)1.63692851
97Abnormality of male internal genitalia (HP:0000022)1.63379863
98Carpal bone hypoplasia (HP:0001498)1.62499526
99Hyperventilation (HP:0002883)1.61608059
100Polyuria (HP:0000103)1.60214204

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.28190170
2TAOK33.52279848
3FRK3.05900044
4RIPK42.58197228
5ADRBK22.46407140
6SIK22.27598938
7EIF2AK32.15979440
8IKBKE2.13394309
9SYK2.11506909
10IKBKB1.97162503
11MAP3K141.95336446
12MAPK131.95173650
13MAP4K21.93039976
14GRK11.90876049
15IRAK41.88538800
16PASK1.86561474
17TXK1.83636504
18BLK1.78207575
19KIT1.69385527
20BMPR1B1.58535499
21CSF1R1.51031024
22PRKCQ1.47183111
23NUAK11.46286656
24TLK11.46271411
25CHUK1.38877995
26TEC1.29815229
27NME11.28508747
28TBK11.27657719
29BTK1.27298996
30LYN1.25751201
31SIK31.25276096
32PTK2B1.23742503
33WNK31.23498196
34NEK91.19249305
35ITK1.18471627
36MAP3K41.16804987
37ZAK1.16710964
38ACVR1B1.13171947
39MAPKAPK51.07369617
40OXSR11.03888649
41TNK21.01466719
42DAPK20.94468285
43BMPR20.86647456
44WNK40.86175936
45PRKCI0.85799459
46TYK20.85541394
47IRAK10.85409307
48MKNK20.85001950
49MAPKAPK30.84759430
50INSRR0.82544319
51PRKCH0.81117506
52JAK10.78735275
53MAPK110.77875351
54TNIK0.77539398
55CDK190.76938155
56BCKDK0.72637770
57HCK0.72506516
58JAK30.69568901
59STK38L0.69392565
60PIM10.69019531
61LCK0.65832319
62PAK30.64712659
63CCNB10.63909445
64MARK30.63090690
65MATK0.61688821
66MAP3K100.61663878
67PRPF4B0.60011452
68MAPK70.59472090
69ERN10.58922980
70CAMKK20.58334173
71MST40.57962412
72PINK10.56190172
73GRK60.53590112
74FLT30.53007755
75ATR0.51644008
76MAP2K60.51482123
77TIE10.50465943
78HIPK20.48937067
79TAF10.48407313
80BCR0.46707967
81RPS6KA50.45680155
82EPHA30.45623436
83STK240.43080282
84PRKCZ0.42973366
85CAMKK10.42931526
86MUSK0.42059588
87CDK40.41978181
88MAP2K70.41976440
89TGFBR10.40696848
90ABL10.40310304
91BRD40.37167466
92STK110.36797352
93VRK10.35830202
94MAP2K20.35149448
95EIF2AK20.34846417
96MAP3K130.34230008
97EEF2K0.33907561
98PKN10.33829997
99PRKCG0.32973815
100VRK20.32622097

Predicted pathways (KEGG)

RankGene SetZ-score
1Intestinal immune network for IgA production_Homo sapiens_hsa046725.32673897
2Primary immunodeficiency_Homo sapiens_hsa053404.24222673
3Allograft rejection_Homo sapiens_hsa053304.16544914
4Autoimmune thyroid disease_Homo sapiens_hsa053203.82966117
5Graft-versus-host disease_Homo sapiens_hsa053323.78897943
6Asthma_Homo sapiens_hsa053103.78053516
7Type I diabetes mellitus_Homo sapiens_hsa049403.46644986
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.40641866
9Antigen processing and presentation_Homo sapiens_hsa046122.15643403
10Viral myocarditis_Homo sapiens_hsa054161.81289750
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.78641003
12B cell receptor signaling pathway_Homo sapiens_hsa046621.72623280
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68606662
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53075694
15Herpes simplex infection_Homo sapiens_hsa051681.52886127
16Homologous recombination_Homo sapiens_hsa034401.47858282
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46137708
18Phototransduction_Homo sapiens_hsa047441.41711181
19Leishmaniasis_Homo sapiens_hsa051401.41312128
20Protein export_Homo sapiens_hsa030601.40769924
21RNA degradation_Homo sapiens_hsa030181.38586168
22Staphylococcus aureus infection_Homo sapiens_hsa051501.37343119
23Linoleic acid metabolism_Homo sapiens_hsa005911.35998917
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32759303
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31395428
26Rheumatoid arthritis_Homo sapiens_hsa053231.22014591
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18438398
28Selenocompound metabolism_Homo sapiens_hsa004501.16774642
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16615282
30Epstein-Barr virus infection_Homo sapiens_hsa051691.15269942
31Basal transcription factors_Homo sapiens_hsa030221.15088275
32RNA polymerase_Homo sapiens_hsa030201.13957548
33Butanoate metabolism_Homo sapiens_hsa006501.13159797
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11272001
35Measles_Homo sapiens_hsa051621.10464228
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08559279
37Influenza A_Homo sapiens_hsa051641.08365984
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05661877
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.04690807
40Fanconi anemia pathway_Homo sapiens_hsa034601.03089506
41Ether lipid metabolism_Homo sapiens_hsa005651.00698984
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98827447
43Hematopoietic cell lineage_Homo sapiens_hsa046400.95234352
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.91225152
45One carbon pool by folate_Homo sapiens_hsa006700.88289171
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88127879
47Nitrogen metabolism_Homo sapiens_hsa009100.82894666
48Non-homologous end-joining_Homo sapiens_hsa034500.82046808
49Tuberculosis_Homo sapiens_hsa051520.81331789
50Toxoplasmosis_Homo sapiens_hsa051450.81002662
51T cell receptor signaling pathway_Homo sapiens_hsa046600.80109683
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71823301
53Taste transduction_Homo sapiens_hsa047420.68297800
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67979262
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66722059
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62365355
57Tryptophan metabolism_Homo sapiens_hsa003800.61366683
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58872892
59Olfactory transduction_Homo sapiens_hsa047400.58161386
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57178585
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55402923
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52606913
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.50812271
64Caffeine metabolism_Homo sapiens_hsa002320.49250796
65ABC transporters_Homo sapiens_hsa020100.49216624
66Nicotine addiction_Homo sapiens_hsa050330.45369420
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44072159
68Oxidative phosphorylation_Homo sapiens_hsa001900.43415610
69Base excision repair_Homo sapiens_hsa034100.43176161
70Pyrimidine metabolism_Homo sapiens_hsa002400.41942611
71Hepatitis B_Homo sapiens_hsa051610.38196643
72Apoptosis_Homo sapiens_hsa042100.37830635
73Purine metabolism_Homo sapiens_hsa002300.37807389
74TNF signaling pathway_Homo sapiens_hsa046680.37383411
75RNA transport_Homo sapiens_hsa030130.37356827
76p53 signaling pathway_Homo sapiens_hsa041150.37285073
77Morphine addiction_Homo sapiens_hsa050320.36278514
78Parkinsons disease_Homo sapiens_hsa050120.36102561
79Chemokine signaling pathway_Homo sapiens_hsa040620.31961498
80Systemic lupus erythematosus_Homo sapiens_hsa053220.31583656
81Glycerolipid metabolism_Homo sapiens_hsa005610.30261268
82Spliceosome_Homo sapiens_hsa030400.28547783
83Peroxisome_Homo sapiens_hsa041460.27472935
84Propanoate metabolism_Homo sapiens_hsa006400.27208562
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.26884029
86HTLV-I infection_Homo sapiens_hsa051660.25049343
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24593917
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23807142
89Arachidonic acid metabolism_Homo sapiens_hsa005900.22580884
90Osteoclast differentiation_Homo sapiens_hsa043800.22454673
91Phagosome_Homo sapiens_hsa041450.20360070
92Collecting duct acid secretion_Homo sapiens_hsa049660.18114379
93Calcium signaling pathway_Homo sapiens_hsa040200.17886337
94Proteasome_Homo sapiens_hsa030500.17462686
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15525389
96Ovarian steroidogenesis_Homo sapiens_hsa049130.15090387
97Hepatitis C_Homo sapiens_hsa051600.14689027
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11756432
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.10653279
100Serotonergic synapse_Homo sapiens_hsa047260.10041811

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »