TBC1D28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)9.19678718
2chromosome condensation (GO:0030261)9.12632649
3DNA packaging (GO:0006323)8.96261567
4response to pheromone (GO:0019236)8.90355392
5plasma membrane fusion (GO:0045026)8.71556623
6microtubule depolymerization (GO:0007019)8.42073030
7spermatid development (GO:0007286)8.37261907
8single strand break repair (GO:0000012)7.80471829
9sperm-egg recognition (GO:0035036)7.70062943
10spermatid nucleus differentiation (GO:0007289)7.65733995
11multicellular organism reproduction (GO:0032504)7.19805611
12binding of sperm to zona pellucida (GO:0007339)7.16116390
13negative regulation of inclusion body assembly (GO:0090084)6.97356867
14microtubule polymerization or depolymerization (GO:0031109)6.88647899
15rRNA methylation (GO:0031167)6.71833269
16reproduction (GO:0000003)6.70234088
17protein polyglutamylation (GO:0018095)6.63441027
18calcium ion-dependent exocytosis (GO:0017156)6.63071531
19protein targeting to Golgi (GO:0000042)6.53371250
20phosphatidylethanolamine biosynthetic process (GO:0006646)6.41444705
21cell-cell recognition (GO:0009988)6.34846362
22sexual reproduction (GO:0019953)6.28392415
23establishment of protein localization to Golgi (GO:0072600)6.27621356
24spermatogenesis (GO:0007283)6.25230468
25male gamete generation (GO:0048232)6.23254389
26axonemal dynein complex assembly (GO:0070286)6.16975814
27retrograde transport, vesicle recycling within Golgi (GO:0000301)6.06128628
28phosphatidylethanolamine metabolic process (GO:0046337)5.91439475
29microtubule severing (GO:0051013)5.75000097
30gamete generation (GO:0007276)5.72675656
31rRNA modification (GO:0000154)5.63820326
32centriole replication (GO:0007099)5.60502506
33cellular ketone body metabolic process (GO:0046950)5.26378993
34regulation of cilium movement (GO:0003352)5.19387706
35centriole assembly (GO:0098534)5.03304254
36single fertilization (GO:0007338)4.96653439
37motile cilium assembly (GO:0044458)4.96182482
38regulation of inclusion body assembly (GO:0090083)4.91643784
39germ cell development (GO:0007281)4.79667422
40regulation of transcription involved in cell fate commitment (GO:0060850)4.72150847
41cilium or flagellum-dependent cell motility (GO:0001539)4.71302251
42protein localization to Golgi apparatus (GO:0034067)4.66689870
43ketone body metabolic process (GO:1902224)4.63725213
44multicellular organismal reproductive process (GO:0048609)4.59121158
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58332730
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.56928461
47regulation of centriole replication (GO:0046599)4.52102711
48RNA destabilization (GO:0050779)4.51639932
49* regulation of Rab GTPase activity (GO:0032313)4.50938384
50* positive regulation of Rab GTPase activity (GO:0032851)4.50938384
51cell wall macromolecule catabolic process (GO:0016998)4.48819639
52fertilization (GO:0009566)4.31770937
53cell wall macromolecule metabolic process (GO:0044036)4.31651594
54chromatin silencing (GO:0006342)4.29106080
55seminiferous tubule development (GO:0072520)4.19390917
56epithelial cilium movement (GO:0003351)4.08396403
57nucleus organization (GO:0006997)4.02035140
58coenzyme catabolic process (GO:0009109)3.92628042
59organic cation transport (GO:0015695)3.90695009
60histone H3-K9 demethylation (GO:0033169)3.82376136
61regulation of microtubule-based movement (GO:0060632)3.78094351
62negative regulation of Rho protein signal transduction (GO:0035024)3.72459887
63male meiosis I (GO:0007141)3.68936102
64musculoskeletal movement (GO:0050881)3.65555201
65multicellular organismal movement (GO:0050879)3.65555201
66male meiosis (GO:0007140)3.61317907
67cilium movement (GO:0003341)3.58502089
68response to acidic pH (GO:0010447)3.54728200
69glycerol ether metabolic process (GO:0006662)3.54398006
70polyamine biosynthetic process (GO:0006596)3.49065930
71regulation of somitogenesis (GO:0014807)3.45134348
72peptidyl-threonine dephosphorylation (GO:0035970)3.43579679
73piRNA metabolic process (GO:0034587)3.34946624
74cellular response to pH (GO:0071467)3.33973266
75cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.32418922
76cerebral cortex neuron differentiation (GO:0021895)3.32299548
77protein-DNA complex disassembly (GO:0032986)3.27563860
78nucleosome disassembly (GO:0006337)3.27563860
79ether metabolic process (GO:0018904)3.26328618
80membrane protein intracellular domain proteolysis (GO:0031293)3.22826003
81DNA methylation involved in gamete generation (GO:0043046)3.19448683
82regulation of phosphoprotein phosphatase activity (GO:0043666)3.18730739
83protein depolymerization (GO:0051261)3.17082661
84glomerular visceral epithelial cell development (GO:0072015)3.10972459
85microtubule nucleation (GO:0007020)3.09670180
86regulation of interleukin-13 production (GO:0032656)3.07190714
87homeostasis of number of cells within a tissue (GO:0048873)3.07131301
88multicellular organismal development (GO:0007275)3.05129850
89cell recognition (GO:0008037)3.03224471
90glomerular epithelial cell development (GO:0072310)3.01126994
91cranial nerve morphogenesis (GO:0021602)2.99728547
92regulation of T-helper 2 cell differentiation (GO:0045628)2.98834165
93DNA conformation change (GO:0071103)2.89630328
94negative regulation of gene expression, epigenetic (GO:0045814)2.89311909
95mesenchymal cell differentiation involved in renal system development (GO:2001012)2.87876614
96mesenchymal cell differentiation involved in kidney development (GO:0072161)2.87876614
97Golgi to endosome transport (GO:0006895)2.83811861
98acrosome reaction (GO:0007340)12.1484339
99sperm motility (GO:0030317)11.8009636
100fusion of sperm to egg plasma membrane (GO:0007342)11.4940727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.66610618
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.63843475
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.57498443
4POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.43577311
5TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43577311
6EZH2_22144423_ChIP-Seq_EOC_Human2.36244973
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24201358
8VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.20158443
9CBP_20019798_ChIP-Seq_JUKART_Human2.16058964
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.16058964
11ELF1_20517297_ChIP-Seq_JURKAT_Human2.07847997
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07264218
13ERA_21632823_ChIP-Seq_H3396_Human2.00597556
14FUS_26573619_Chip-Seq_HEK293_Human1.92744828
15RAC3_21632823_ChIP-Seq_H3396_Human1.92104305
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87628217
17RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.85856007
18EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.85184842
19NANOG_20526341_ChIP-Seq_ESCs_Human1.83355752
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81721724
21EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.81004388
22WDR5_24793694_ChIP-Seq_LNCAP_Human1.78059985
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77504365
24DROSHA_22980978_ChIP-Seq_HELA_Human1.77422370
25CTCF_27219007_Chip-Seq_Bcells_Human1.73884789
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70708411
27BCL6_27268052_Chip-Seq_Bcells_Human1.66612602
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66537215
29MYC_19829295_ChIP-Seq_ESCs_Human1.65674345
30ER_23166858_ChIP-Seq_MCF-7_Human1.63274021
31SMC4_20622854_ChIP-Seq_HELA_Human1.62931532
32YY1_22570637_ChIP-Seq_MALME-3M_Human1.61848027
33TAF2_19829295_ChIP-Seq_ESCs_Human1.60617625
34E2F1_20622854_ChIP-Seq_HELA_Human1.60221056
35SMAD4_21741376_ChIP-Seq_EPCs_Human1.55643376
36TDRD3_21172665_ChIP-Seq_MCF-7_Human1.55495318
37AUTS2_25519132_ChIP-Seq_293T-REX_Human1.54940085
38ARNT_22903824_ChIP-Seq_MCF-7_Human1.52034924
39P68_20966046_ChIP-Seq_HELA_Human1.50214981
40BCOR_27268052_Chip-Seq_Bcells_Human1.50195633
41OCT4_20526341_ChIP-Seq_ESCs_Human1.49362117
42CTCF_20526341_ChIP-Seq_ESCs_Human1.47857444
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44524518
44AR_25329375_ChIP-Seq_VCAP_Human1.43055621
45TP63_22573176_ChIP-Seq_HFKS_Human1.41747611
46* PHF8_20622854_ChIP-Seq_HELA_Human1.41196460
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.39513983
48TP53_18474530_ChIP-ChIP_U2OS_Human1.36826037
49HNFA_21074721_ChIP-Seq_CACO-2_Human1.35705687
50P300_27268052_Chip-Seq_Bcells_Human1.35409748
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35223706
52ERG_20517297_ChIP-Seq_VCAP_Human1.34680437
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34063534
54CBX2_22325352_ChIP-Seq_293T-Rex_Human1.32296092
55RBPJ_21746931_ChIP-Seq_IB4_Human1.32279091
56CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.31002593
57LXR_22292898_ChIP-Seq_THP-1_Human1.30325904
58SMAD3_21741376_ChIP-Seq_ESCs_Human1.30144116
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29114532
60ETV1_20927104_ChIP-Seq_GIST48_Human1.27206465
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27070629
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.26927775
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.26448178
64P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.26338547
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24778742
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.24130349
67TAF15_26573619_Chip-Seq_HEK293_Human1.23666234
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22340973
69P300_19829295_ChIP-Seq_ESCs_Human1.22093321
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21847502
71CEBPB_22108803_ChIP-Seq_LS180_Human1.21145081
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.20615124
73KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.18670503
74SOX2_22085726_ChIP-Seq_NPCs_Mouse1.18589404
75NFYB_21822215_ChIP-Seq_K562_Human1.18159064
76RUNX1_26923725_Chip-Seq_HPCs_Mouse1.18120855
77P53_21459846_ChIP-Seq_SAOS-2_Human1.17852746
78TBL1_22424771_ChIP-Seq_293T_Human1.15953446
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15167856
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13906542
81SMAD4_21741376_ChIP-Seq_HESCs_Human1.11906862
82RUNX2_22187159_ChIP-Seq_PCA_Human1.11606127
83NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11498066
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.10631861
85ZNF274_21170338_ChIP-Seq_K562_Hela1.10577650
86RUNX_20019798_ChIP-Seq_JUKART_Human1.09837945
87PHF8_20622853_ChIP-Seq_HELA_Human1.09544709
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.08696514
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07375533
90SA1_27219007_Chip-Seq_Bcells_Human1.06118334
91GATA6_21074721_ChIP-Seq_CACO-2_Human1.05493326
92SMRT_27268052_Chip-Seq_Bcells_Human1.05463469
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04878630
94SOX2_19829295_ChIP-Seq_ESCs_Human1.04391175
95NANOG_19829295_ChIP-Seq_ESCs_Human1.04391175
96OCT1_27270436_Chip-Seq_PROSTATE_Human1.03448850
97HOXB7_26014856_ChIP-Seq_BT474_Human1.01430206
98NFYA_21822215_ChIP-Seq_K562_Human0.98752138
99E2F1_17053090_ChIP-ChIP_MCF-7_Human0.98298320
100CBX2_27304074_Chip-Seq_ESCs_Mouse0.97527434

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.01132623
2MP0003878_abnormal_ear_physiology5.01132623
3MP0003698_abnormal_male_reproductive4.70459183
4MP0005670_abnormal_white_adipose4.50683370
5MP0001929_abnormal_gametogenesis4.16233489
6MP0001348_abnormal_lacrimal_gland3.02309708
7MP0000678_abnormal_parathyroid_gland2.67688963
8MP0002161_abnormal_fertility/fecundity2.63818424
9MP0003718_maternal_effect2.27510468
10MP0002210_abnormal_sex_determination2.06927233
11MP0002132_abnormal_respiratory_system2.06908384
12MP0005410_abnormal_fertilization12.5252092
13MP0003646_muscle_fatigue1.99839969
14MP0003011_delayed_dark_adaptation1.90455976
15MP0005423_abnormal_somatic_nervous1.71524635
16MP0001145_abnormal_male_reproductive1.70122479
17MP0002234_abnormal_pharynx_morphology1.68744764
18MP0002249_abnormal_larynx_morphology1.68131080
19MP0000653_abnormal_sex_gland1.61061555
20MP0001485_abnormal_pinna_reflex1.51824821
21MP0005379_endocrine/exocrine_gland_phen1.51467522
22MP0005310_abnormal_salivary_gland1.46332982
23MP0008877_abnormal_DNA_methylation1.44887392
24MP0001486_abnormal_startle_reflex1.43644221
25MP0002282_abnormal_trachea_morphology1.41431524
26MP0004510_myositis1.32566137
27MP0002822_catalepsy1.29089648
28MP0009053_abnormal_anal_canal1.27253759
29MP0004742_abnormal_vestibular_system1.26463214
30MP0000534_abnormal_ureter_morphology1.14250149
31MP0001765_abnormal_ion_homeostasis1.14096214
32MP0004859_abnormal_synaptic_plasticity1.11826337
33MP0005451_abnormal_body_composition1.10343200
34MP0001968_abnormal_touch/_nociception1.10171744
35MP0002138_abnormal_hepatobiliary_system1.09043528
36MP0001963_abnormal_hearing_physiology1.08955683
37MP0002127_abnormal_cardiovascular_syste1.05658283
38MP0002735_abnormal_chemical_nociception1.04095657
39MP0005248_abnormal_Harderian_gland1.03670289
40MP0005395_other_phenotype1.01871674
41MP0000026_abnormal_inner_ear0.97988432
42MP0003879_abnormal_hair_cell0.97313339
43MP0000955_abnormal_spinal_cord0.88272267
44MP0000681_abnormal_thyroid_gland0.87267901
45MP0002229_neurodegeneration0.83706284
46MP0000049_abnormal_middle_ear0.79992812
47MP0002067_abnormal_sensory_capabilities0.76598305
48MP0005551_abnormal_eye_electrophysiolog0.75423298
49MP0009115_abnormal_fat_cell0.73238457
50MP0001905_abnormal_dopamine_level0.71922447
51MP0008995_early_reproductive_senescence0.70504610
52MP0005666_abnormal_adipose_tissue0.69850142
53MP0008569_lethality_at_weaning0.69556323
54MP0004085_abnormal_heartbeat0.69490357
55MP0005367_renal/urinary_system_phenotyp0.67918293
56MP0000516_abnormal_urinary_system0.67918293
57MP0009697_abnormal_copulation0.67852254
58MP0002733_abnormal_thermal_nociception0.66631596
59MP0002557_abnormal_social/conspecific_i0.65032893
60MP0001666_abnormal_nutrient_absorption0.63442313
61MP0005083_abnormal_biliary_tract0.63204080
62MP0001879_abnormal_lymphatic_vessel0.62785241
63MP0005636_abnormal_mineral_homeostasis0.60069694
64MP0005253_abnormal_eye_physiology0.59461670
65MP0005375_adipose_tissue_phenotype0.59213205
66MP0001984_abnormal_olfaction0.58718535
67MP0003699_abnormal_female_reproductive0.57470192
68MP0004484_altered_response_of0.54272682
69MP0002572_abnormal_emotion/affect_behav0.53317603
70MP0000003_abnormal_adipose_tissue0.53222378
71MP0005647_abnormal_sex_gland0.53203283
72MP0002272_abnormal_nervous_system0.52770393
73MP0003119_abnormal_digestive_system0.52560115
74MP0003077_abnormal_cell_cycle0.51405958
75MP0005167_abnormal_blood-brain_barrier0.49164628
76MP0009745_abnormal_behavioral_response0.46504997
77MP0001970_abnormal_pain_threshold0.45624675
78MP0003137_abnormal_impulse_conducting0.44806250
79MP0001501_abnormal_sleep_pattern0.44739925
80MP0001440_abnormal_grooming_behavior0.44470916
81MP0000470_abnormal_stomach_morphology0.44310288
82MP0002653_abnormal_ependyma_morphology0.43952196
83MP0005623_abnormal_meninges_morphology0.43035821
84MP0003880_abnormal_central_pattern0.43007342
85MP0000249_abnormal_blood_vessel0.41773269
86MP0002734_abnormal_mechanical_nocicepti0.41474700
87MP0003936_abnormal_reproductive_system0.41187979
88MP0002160_abnormal_reproductive_system0.40429341
89MP0001119_abnormal_female_reproductive0.40374153
90MP0000613_abnormal_salivary_gland0.39051269
91MP0004233_abnormal_muscle_weight0.37670758
92MP0006292_abnormal_olfactory_placode0.35528701
93MP0000566_synostosis0.34501713
94MP0005535_abnormal_body_temperature0.34444590
95MP0008789_abnormal_olfactory_epithelium0.34257265
96MP0000230_abnormal_systemic_arterial0.34219248
97MP0004036_abnormal_muscle_relaxation0.33845010
98MP0003635_abnormal_synaptic_transmissio0.33775563
99MP0008961_abnormal_basal_metabolism0.33528526
100MP0002928_abnormal_bile_duct0.31391477

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.11004175
2Absent/shortened dynein arms (HP:0200106)5.95202899
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.95202899
4Asymmetric septal hypertrophy (HP:0001670)5.31610685
5Tubulointerstitial nephritis (HP:0001970)5.03182966
6Attenuation of retinal blood vessels (HP:0007843)5.02848017
7Bony spicule pigmentary retinopathy (HP:0007737)4.99240364
8Resting tremor (HP:0002322)4.92476900
9Abnormal ciliary motility (HP:0012262)4.61018807
10Bell-shaped thorax (HP:0001591)4.59478814
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.57172415
12Abnormal respiratory motile cilium physiology (HP:0012261)4.54744275
13Chronic hepatic failure (HP:0100626)4.40285477
14Abnormal respiratory epithelium morphology (HP:0012253)4.36468436
15Abnormal respiratory motile cilium morphology (HP:0005938)4.36468436
16Infertility (HP:0000789)4.25960618
17Male infertility (HP:0003251)4.18181332
18Hyperkalemia (HP:0002153)4.17501290
19Nasal polyposis (HP:0100582)4.15552506
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.07625805
21Abnormal rod and cone electroretinograms (HP:0008323)4.02293981
22Hypoplastic ischia (HP:0003175)3.99108717
23Abnormality of macular pigmentation (HP:0008002)3.98497631
24Azoospermia (HP:0000027)3.91588704
25Facial shape deformation (HP:0011334)3.87972173
26Potter facies (HP:0002009)3.87972173
27Enlarged epiphyses (HP:0010580)3.86164359
28Abnormal spermatogenesis (HP:0008669)3.77131787
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.74573700
30Cone-rod dystrophy (HP:0000548)3.59575860
31Abnormality of the ischium (HP:0003174)3.56810703
32Impulsivity (HP:0100710)3.39008236
33Abnormality of the nasal mucosa (HP:0000433)3.35842201
34Hypoplasia of the thymus (HP:0000778)3.26096097
35Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.15871753
36Postural instability (HP:0002172)3.12538130
37Nephronophthisis (HP:0000090)2.89721473
38Unilateral renal agenesis (HP:0000122)2.87999910
39Abnormal urine output (HP:0012590)2.76559278
40Rhinitis (HP:0012384)2.74565687
41Congenital malformation of the right heart (HP:0011723)2.74236650
42Double outlet right ventricle (HP:0001719)2.74236650
43Progressive sensorineural hearing impairment (HP:0000408)2.69659188
44Abnormality of the aortic arch (HP:0012303)2.69653632
45Truncal obesity (HP:0001956)2.69462375
46Generalized aminoaciduria (HP:0002909)2.69002133
47Stage 5 chronic kidney disease (HP:0003774)2.68300102
48Renal dysplasia (HP:0000110)2.64276991
49Hypoalphalipoproteinemia (HP:0003233)2.64229081
50Amelogenesis imperfecta (HP:0000705)2.54916518
51Abnormality of the renal medulla (HP:0100957)2.47972547
52Tubulointerstitial abnormality (HP:0001969)2.46422912
53Portal hypertension (HP:0001409)2.44491067
54Abnormal drinking behavior (HP:0030082)2.43949271
55Polydipsia (HP:0001959)2.43949271
56Progressive cerebellar ataxia (HP:0002073)2.43120478
57Abnormality of potassium homeostasis (HP:0011042)2.41658008
58Abnormality of dental color (HP:0011073)2.41277296
59Menstrual irregularities (HP:0000858)2.40119031
60Abnormality of renal excretion (HP:0011036)2.39231558
61Abnormality of the costochondral junction (HP:0000919)2.38858116
62Epiphyseal dysplasia (HP:0002656)2.35849328
63Insulin-resistant diabetes mellitus (HP:0000831)2.33968472
64Renovascular hypertension (HP:0100817)2.32516827
65Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.29213095
66Absent epiphyses (HP:0010577)2.29213095
67Flattened epiphyses (HP:0003071)2.27050205
68Abnormality of the hepatic vasculature (HP:0006707)2.24045915
69Abnormality of the parathyroid morphology (HP:0011766)2.23766820
70Osteomalacia (HP:0002749)2.23049721
71Polyuria (HP:0000103)2.22379481
72Ventricular tachycardia (HP:0004756)2.21021391
73Bronchiectasis (HP:0002110)2.06006799
74Hypophosphatemic rickets (HP:0004912)2.03797362
75Abnormality of the epiphysis of the femoral head (HP:0010574)2.03692830
76Hyponatremia (HP:0002902)2.01852460
77Tetany (HP:0001281)2.00293926
78Abnormality of the pubic bones (HP:0003172)1.95242578
79Recurrent pneumonia (HP:0006532)1.93405619
80Widely patent fontanelles and sutures (HP:0004492)1.93014070
81Chronic bronchitis (HP:0004469)1.92452828
82Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.89511348
83Abnormality of femoral epiphyses (HP:0006499)1.89511348
84Recurrent corneal erosions (HP:0000495)1.89231183
85Decreased central vision (HP:0007663)1.86659606
86Intellectual disability, moderate (HP:0002342)1.83438125
87Optic nerve hypoplasia (HP:0000609)1.83298678
88Short ribs (HP:0000773)1.81979860
89Hyperuricemia (HP:0002149)1.79860637
90Increased purine levels (HP:0004368)1.79860637
91Abnormality of the femoral head (HP:0003368)1.79685906
92Flat capital femoral epiphysis (HP:0003370)1.76820324
93Focal segmental glomerulosclerosis (HP:0000097)1.76242719
94Renal Fanconi syndrome (HP:0001994)1.76006217
95Bradycardia (HP:0001662)1.75214921
96Myokymia (HP:0002411)1.75141407
97Transposition of the great arteries (HP:0001669)1.73422293
98Abnormal connection of the cardiac segments (HP:0011545)1.73422293
99Abnormal ventriculo-arterial connection (HP:0011563)1.73422293
100Hyperthyroidism (HP:0000836)1.73346785

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.46661930
2TESK16.00327485
3DDR25.14530264
4INSRR4.11574746
5MAP4K23.26692117
6STK383.22685629
7PNCK3.12997172
8PLK23.11072875
9BRD42.82715944
10STK38L2.54788663
11MAPK152.42357497
12CAMK1G2.29035372
13PRKD32.13274591
14MST1R1.68374019
15PIK3CG1.64437565
16WNK11.63200921
17PDPK11.59967396
18PDK11.52477308
19CDK121.38975762
20DYRK1B1.29143684
21CDK71.26131399
22PTK2B1.25886873
23KSR21.14808963
24MAP3K91.12209925
25NEK61.12100653
26AKT30.91666121
27BRAF0.87560798
28PINK10.79417039
29TYRO30.77569590
30CAMK1D0.76569738
31PRKG20.71564286
32RPS6KA20.70361104
33LATS20.69639532
34SIK20.69270626
35MAP2K20.68389210
36UHMK10.66170703
37MAP3K20.65331643
38PRKG10.63500489
39WNK40.62491575
40RPS6KA10.60940792
41MAP3K110.57457187
42ROCK10.56796061
43LATS10.56655258
44ARAF0.56202709
45PRKAA20.55968329
46CAMK10.55147316
47CDK30.54101669
48MAP3K80.52357467
49STK390.50948731
50CDK20.44125502
51SGK4940.44065240
52SGK2230.44065240
53GSK3B0.42857007
54CDK40.42088906
55BMPR1B0.41118666
56CDK10.39440898
57MAPK10.39262506
58MUSK0.35841110
59RPS6KL10.35822955
60RPS6KC10.35822955
61RPS6KA60.34870059
62CAMK40.33008261
63MAP3K10.31149372
64MTOR0.30919784
65MAPK80.30720280
66CHEK10.30212816
67PRKCG0.29419156
68MET0.28938694
69MARK10.28265660
70PRKCZ0.28096352
71TESK20.27850533
72OXSR10.27633986
73TLK10.27080931
74SGK10.26884760
75NTRK30.26471330
76RIPK40.25729901
77MAP3K40.25537237
78MARK20.23953126
79ZAK0.22347372
80CDK190.22233325
81TIE10.21286877
82MAPK140.20968073
83PRKCB0.20496517
84MAPK100.18208425
85BRSK10.17854997
86DYRK30.17784751
87JAK30.17456424
88NEK20.16581776
89PKN10.16533723
90MAPK110.15242777
91AKT10.14940090
92TNIK0.13632563
93MAP3K130.10467059
94SGK20.08876337
95VRK10.08475954
96GRK70.08452778
97MAP2K70.08236006
98MARK30.07957987
99PRKACB0.06953573
100PRKACA0.06567274

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.48299561
2Fatty acid biosynthesis_Homo sapiens_hsa000616.36827833
3Olfactory transduction_Homo sapiens_hsa047403.75697371
4Butanoate metabolism_Homo sapiens_hsa006502.67521293
5Glycerophospholipid metabolism_Homo sapiens_hsa005642.09884086
6Dorso-ventral axis formation_Homo sapiens_hsa043201.94395530
7Taste transduction_Homo sapiens_hsa047421.80207761
8Allograft rejection_Homo sapiens_hsa053301.79377470
9Autoimmune thyroid disease_Homo sapiens_hsa053201.78710719
10Type I diabetes mellitus_Homo sapiens_hsa049401.76262173
11Phenylalanine metabolism_Homo sapiens_hsa003601.75234479
12Fatty acid degradation_Homo sapiens_hsa000711.71460908
13Graft-versus-host disease_Homo sapiens_hsa053321.63345147
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62432645
15Type II diabetes mellitus_Homo sapiens_hsa049301.61197149
16RNA transport_Homo sapiens_hsa030131.57109512
17Antigen processing and presentation_Homo sapiens_hsa046121.55311684
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52375245
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44626223
20Fatty acid metabolism_Homo sapiens_hsa012121.43809558
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43254221
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.32267912
23Viral myocarditis_Homo sapiens_hsa054161.23361084
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19686437
25Arginine and proline metabolism_Homo sapiens_hsa003301.19023252
26Adipocytokine signaling pathway_Homo sapiens_hsa049201.18744712
27Protein digestion and absorption_Homo sapiens_hsa049741.10670514
28Endocytosis_Homo sapiens_hsa041441.04404215
29Phototransduction_Homo sapiens_hsa047441.02915811
30Oocyte meiosis_Homo sapiens_hsa041140.99386129
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98960050
32Arginine biosynthesis_Homo sapiens_hsa002200.98804874
33Hedgehog signaling pathway_Homo sapiens_hsa043400.97067057
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95966592
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95680977
36Salivary secretion_Homo sapiens_hsa049700.93233234
37PPAR signaling pathway_Homo sapiens_hsa033200.88986227
38Inositol phosphate metabolism_Homo sapiens_hsa005620.88484672
39Calcium signaling pathway_Homo sapiens_hsa040200.87907224
40cAMP signaling pathway_Homo sapiens_hsa040240.84471164
41Selenocompound metabolism_Homo sapiens_hsa004500.83137504
42Synaptic vesicle cycle_Homo sapiens_hsa047210.80820361
43Influenza A_Homo sapiens_hsa051640.77553385
44Morphine addiction_Homo sapiens_hsa050320.75455312
45Tyrosine metabolism_Homo sapiens_hsa003500.74413720
46Cardiac muscle contraction_Homo sapiens_hsa042600.74119905
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73974175
48Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73676216
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73008666
50ABC transporters_Homo sapiens_hsa020100.68517349
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.68202290
52Fat digestion and absorption_Homo sapiens_hsa049750.68005274
53Renin-angiotensin system_Homo sapiens_hsa046140.66979807
54Circadian entrainment_Homo sapiens_hsa047130.65544084
55Nicotine addiction_Homo sapiens_hsa050330.64390773
56Glycerolipid metabolism_Homo sapiens_hsa005610.62581217
57Estrogen signaling pathway_Homo sapiens_hsa049150.62120117
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60697689
59VEGF signaling pathway_Homo sapiens_hsa043700.59130266
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58412211
61Retinol metabolism_Homo sapiens_hsa008300.57667457
62Glutamatergic synapse_Homo sapiens_hsa047240.53665200
63Gastric acid secretion_Homo sapiens_hsa049710.51896595
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.51238150
65MAPK signaling pathway_Homo sapiens_hsa040100.51028025
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50229880
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49183312
68Purine metabolism_Homo sapiens_hsa002300.48721023
69Basal transcription factors_Homo sapiens_hsa030220.47506824
70Renin secretion_Homo sapiens_hsa049240.46080641
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.44395829
72Bile secretion_Homo sapiens_hsa049760.44149885
73mRNA surveillance pathway_Homo sapiens_hsa030150.40982220
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40941192
75Nitrogen metabolism_Homo sapiens_hsa009100.40074438
76Insulin secretion_Homo sapiens_hsa049110.39218626
77Serotonergic synapse_Homo sapiens_hsa047260.38049683
78Acute myeloid leukemia_Homo sapiens_hsa052210.37127268
79Tight junction_Homo sapiens_hsa045300.36412489
80Cholinergic synapse_Homo sapiens_hsa047250.34236915
81Pancreatic secretion_Homo sapiens_hsa049720.32248366
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30269372
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30218687
84Fanconi anemia pathway_Homo sapiens_hsa034600.29957934
85Viral carcinogenesis_Homo sapiens_hsa052030.29878747
86Oxytocin signaling pathway_Homo sapiens_hsa049210.28157786
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.24737138
88Linoleic acid metabolism_Homo sapiens_hsa005910.22627614
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21814445
90Alcoholism_Homo sapiens_hsa050340.21558013
91Long-term potentiation_Homo sapiens_hsa047200.21411237
92Prolactin signaling pathway_Homo sapiens_hsa049170.20561066
93Herpes simplex infection_Homo sapiens_hsa051680.20543815
94ECM-receptor interaction_Homo sapiens_hsa045120.19727212
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.19020086
96GABAergic synapse_Homo sapiens_hsa047270.17366381
97B cell receptor signaling pathway_Homo sapiens_hsa046620.16691580
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14616585
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14503231
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14224178

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »