ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	9.86259328
2	fusion of sperm to egg plasma membrane (GO:0007342)	9.16145326
3	sperm motility (GO:0030317)	9.11387372
4	sperm capacitation (GO:0048240)	8.19431916
5	response to pheromone (GO:0019236)	7.82503092
6	chromosome condensation (GO:0030261)	7.66148038
7	DNA packaging (GO:0006323)	7.35400929
8	single strand break repair (GO:0000012)	6.92005968
9	plasma membrane fusion (GO:0045026)	6.75570860
10	citrulline biosynthetic process (GO:0019240)	6.73095504
11	sexual reproduction (GO:0019953)	6.44242863
12	spermatid nucleus differentiation (GO:0007289)	6.21736366
13	spermatid development (GO:0007286)	6.13051099
14	one-carbon compound transport (GO:0019755)	6.10220814
15	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	5.97279817
16	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.92611996
17	* positive regulation of Rab GTPase activity (GO:0032851)	5.47854086
18	* regulation of Rab GTPase activity (GO:0032313)	5.47854086
19	microtubule depolymerization (GO:0007019)	5.46458759
20	sperm-egg recognition (GO:0035036)	5.36149971
21	calcium ion-dependent exocytosis (GO:0017156)	5.35447864
22	reproduction (GO:0000003)	5.34051553
23	phosphatidylethanolamine metabolic process (GO:0046337)	5.32880397
24	multicellular organism reproduction (GO:0032504)	5.21312082
25	protein targeting to Golgi (GO:0000042)	4.71768652
26	negative regulation of inclusion body assembly (GO:0090084)	4.64492681
27	binding of sperm to zona pellucida (GO:0007339)	4.64409844
28	spermatogenesis (GO:0007283)	4.50846929
29	male gamete generation (GO:0048232)	4.48933181
30	citrulline metabolic process (GO:0000052)	4.48678588
31	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.45422660
32	chromatin silencing (GO:0006342)	4.44278164
33	establishment of protein localization to Golgi (GO:0072600)	4.43726191
34	axonemal dynein complex assembly (GO:0070286)	4.43503178
35	microtubule polymerization or depolymerization (GO:0031109)	4.40457525
36	cell-cell recognition (GO:0009988)	4.38890264
37	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	4.34725922
38	microtubule severing (GO:0051013)	4.34716712
39	rRNA methylation (GO:0031167)	4.32956025
40	regulation of transcription involved in cell fate commitment (GO:0060850)	4.31305813
41	protein polyglutamylation (GO:0018095)	4.27751929
42	regulation of T-helper 2 cell differentiation (GO:0045628)	4.27743437
43	motile cilium assembly (GO:0044458)	4.20696432
44	centriole replication (GO:0007099)	4.13865377
45	peptidyl-arginine modification (GO:0018195)	4.12494216
46	gas transport (GO:0015669)	4.09180420
47	gamete generation (GO:0007276)	4.04030068
48	cell wall macromolecule metabolic process (GO:0044036)	3.88633579
49	regulation of cilium movement (GO:0003352)	3.88277488
50	centriole assembly (GO:0098534)	3.76324124
51	RNA destabilization (GO:0050779)	3.73488705
52	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.69844007
53	cell wall macromolecule catabolic process (GO:0016998)	3.69366846
54	regulation of interleukin-13 production (GO:0032656)	3.68941389
55	regulation of ARF GTPase activity (GO:0032312)	3.59016396
56	germ cell development (GO:0007281)	3.54956314
57	response to acidic pH (GO:0010447)	3.53067522
58	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.48254245
59	nucleosome disassembly (GO:0006337)	3.46911404
60	protein-DNA complex disassembly (GO:0032986)	3.46911404
61	single fertilization (GO:0007338)	3.45244711
62	protein localization to Golgi apparatus (GO:0034067)	3.42322993
63	cerebral cortex neuron differentiation (GO:0021895)	3.41896343
64	camera-type eye morphogenesis (GO:0048593)	3.36804235
65	rRNA modification (GO:0000154)	3.35662743
66	peptide catabolic process (GO:0043171)	3.34544547
67	regulation of histone H3-K27 methylation (GO:0061085)	3.30950674
68	regulation of inclusion body assembly (GO:0090083)	3.30295366
69	multicellular organismal reproductive process (GO:0048609)	3.28634966
70	cell-cell junction maintenance (GO:0045217)	3.28322388
71	cilium or flagellum-dependent cell motility (GO:0001539)	3.25300203
72	cellular ketone body metabolic process (GO:0046950)	3.22497697
73	negative regulation of gene expression, epigenetic (GO:0045814)	3.21632081
74	negative regulation of granulocyte differentiation (GO:0030853)	3.19738784
75	nucleus organization (GO:0006997)	3.19618516
76	histone H3-K9 demethylation (GO:0033169)	3.19573596
77	apoptotic cell clearance (GO:0043277)	3.17577176
78	cranial nerve morphogenesis (GO:0021602)	3.16350702
79	face development (GO:0060324)	3.13540314
80	branching involved in salivary gland morphogenesis (GO:0060445)	3.12960465
81	positive regulation of type 2 immune response (GO:0002830)	3.12584562
82	positive regulation of histone deacetylation (GO:0031065)	3.11749262
83	histone H4 deacetylation (GO:0070933)	3.10879363
84	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.07889792
85	organic cation transport (GO:0015695)	3.06626861
86	cellular response to pH (GO:0071467)	3.05540308
87	homeostasis of number of cells within a tissue (GO:0048873)	3.02754741
88	negative regulation of Rho protein signal transduction (GO:0035024)	2.98488776
89	negative regulation of histone methylation (GO:0031061)	2.96836334
90	fertilization (GO:0009566)	2.86290401
91	regulation of centriole replication (GO:0046599)	2.86054852
92	peptidyl-threonine dephosphorylation (GO:0035970)	2.82549354
93	regulation of microtubule-based movement (GO:0060632)	2.81803674
94	seminiferous tubule development (GO:0072520)	2.80325400
95	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.74817603
96	membrane protein intracellular domain proteolysis (GO:0031293)	2.73209109
97	ketone body metabolic process (GO:1902224)	2.72696559
98	regulation of interleukin-5 production (GO:0032674)	2.69752204
99	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.69095238
100	polyamine biosynthetic process (GO:0006596)	2.68085287

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	8.28126279
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.87313481
3	LXR_22292898_ChIP-Seq_THP-1_Human	2.84348153
4	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.36699072
5	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.32341053
6	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.18013666
7	SMC4_20622854_ChIP-Seq_HELA_Human	2.17594061
8	BCL6_27268052_Chip-Seq_Bcells_Human	2.09132041
9	P68_20966046_ChIP-Seq_HELA_Human	2.07202985
10	CTCF_27219007_Chip-Seq_Bcells_Human	2.06503755
11	BCOR_27268052_Chip-Seq_Bcells_Human	2.02327378
12	GATA1_19941826_ChIP-Seq_K562_Human	1.96193353
13	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.85885334
14	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.81913320
15	E2F1_20622854_ChIP-Seq_HELA_Human	1.78845217
16	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.77965897
17	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.76682031
18	SA1_27219007_Chip-Seq_Bcells_Human	1.76435510
19	PHF8_20622854_ChIP-Seq_HELA_Human	1.76342617
20	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.75550161
21	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.73069895
22	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.71063229
23	KDM2B_26808549_Chip-Seq_DND41_Human	1.69351967
24	TP63_22573176_ChIP-Seq_HFKS_Human	1.66183539
25	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.63969775
26	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.54284067
27	TCF7_22412390_ChIP-Seq_EML_Mouse	1.54114819
28	KDM2B_26808549_Chip-Seq_K562_Human	1.51823953
29	RACK7_27058665_Chip-Seq_MCF-7_Human	1.50663312
30	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.50618503
31	CTCF_20526341_ChIP-Seq_ESCs_Human	1.49995531
32	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.49779109
33	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.49731316
34	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.47993457
35	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.45760852
36	RAC3_21632823_ChIP-Seq_H3396_Human	1.44953465
37	ERA_21632823_ChIP-Seq_H3396_Human	1.42867148
38	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.42644100
39	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.39752139
40	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.39659550
41	P300_27268052_Chip-Seq_Bcells_Human	1.36480125
42	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.35708704
43	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.35542115
44	SPI1_23127762_ChIP-Seq_K562_Human	1.35465620
45	NANOG_20526341_ChIP-Seq_ESCs_Human	1.35115172
46	DROSHA_22980978_ChIP-Seq_HELA_Human	1.33978427
47	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.33378235
48	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.32245208
49	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.30967860
50	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.30864179
51	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.28932440
52	KLF5_25053715_ChIP-Seq_YYC3_Human	1.28874279
53	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.28204169
54	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.26032455
55	TP53_22127205_ChIP-Seq_IMR90_Human	1.25276826
56	MAF_26560356_Chip-Seq_TH2_Human	1.24854532
57	SCL_19346495_ChIP-Seq_HPC-7_Human	1.24787815
58	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.24137887
59	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.23792015
60	NCOR1_26117541_ChIP-Seq_K562_Human	1.21155652
61	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.20005648
62	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.19482064
63	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.18889480
64	CTCF_21964334_Chip-Seq_Bcells_Human	1.16770327
65	MAF_26560356_Chip-Seq_TH1_Human	1.16194673
66	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.13967908
67	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.13719655
68	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13243870
69	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.12981082
70	OCT4_19829295_ChIP-Seq_ESCs_Human	1.07455050
71	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.07331463
72	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06883059
73	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.06626590
74	OCT4_20526341_ChIP-Seq_ESCs_Human	1.06165997
75	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.06067482
76	GATA2_19941826_ChIP-Seq_K562_Human	1.04958357
77	CREB1_26743006_Chip-Seq_LNCaP_Human	1.04777990
78	VDR_21846776_ChIP-Seq_THP-1_Human	1.04398293
79	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.03388355
80	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.03110847
81	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.01022152
82	SPI1_20517297_ChIP-Seq_HL60_Human	1.00281299
83	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.99640000
84	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.98993174
85	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.97586825
86	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.97019615
87	VDR_24763502_ChIP-Seq_THP-1_Human	0.96829700
88	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96454458
89	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.96454458
90	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	0.95334360
91	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.95108221
92	ATF3_27146783_Chip-Seq_COLON_Human	0.95096758
93	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.94541980
94	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.94152946
95	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.93981968
96	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.93275312
97	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.93242324
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.93147312
99	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.91932482
100	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.91541847

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	9.39626415
2	MP0003878_abnormal_ear_physiology	5.48948284
3	MP0005377_hearing/vestibular/ear_phenot	5.48948284
4	MP0005670_abnormal_white_adipose	4.22888711
5	MP0001348_abnormal_lacrimal_gland	4.13306325
6	MP0003698_abnormal_male_reproductive	3.12674826
7	MP0000678_abnormal_parathyroid_gland	3.12468812
8	MP0005451_abnormal_body_composition	2.74527158
9	MP0002132_abnormal_respiratory_system	2.66102010
10	MP0004510_myositis	2.65409882
11	MP0001929_abnormal_gametogenesis	2.60874822
12	MP0002138_abnormal_hepatobiliary_system	2.60248484
13	MP0003436_decreased_susceptibility_to	2.26848556
14	MP0005083_abnormal_biliary_tract	2.17998556
15	MP0009053_abnormal_anal_canal	1.91360129
16	MP0002161_abnormal_fertility/fecundity	1.78539045
17	MP0002249_abnormal_larynx_morphology	1.54916317
18	MP0002282_abnormal_trachea_morphology	1.53821264
19	MP0009764_decreased_sensitivity_to	1.50899173
20	MP0003172_abnormal_lysosome_physiology	1.40422579
21	MP0000534_abnormal_ureter_morphology	1.36155203
22	MP0005248_abnormal_Harderian_gland	1.33943542
23	MP0003303_peritoneal_inflammation	1.32226839
24	MP0001873_stomach_inflammation	1.31254898
25	MP0003300_gastrointestinal_ulcer	1.21597708
26	MP0005666_abnormal_adipose_tissue	1.20197042
27	MP0002210_abnormal_sex_determination	1.19863024
28	MP0009278_abnormal_bone_marrow	1.18662878
29	MP0000685_abnormal_immune_system	1.14639647
30	MP0003566_abnormal_cell_adhesion	1.11339747
31	MP0001849_ear_inflammation	1.10376484
32	MP0004947_skin_inflammation	1.09331357
33	MP0005310_abnormal_salivary_gland	1.09329565
34	MP0002822_catalepsy	1.06492699
35	MP0001533_abnormal_skeleton_physiology	1.06433517
36	MP0002419_abnormal_innate_immunity	1.06126260
37	MP0005164_abnormal_response_to	1.00324407
38	MP0004264_abnormal_extraembryonic_tissu	0.99136421
39	MP0003656_abnormal_erythrocyte_physiolo	0.96039885
40	MP0002933_joint_inflammation	0.92825662
41	MP0003448_altered_tumor_morphology	0.92625206
42	MP0001765_abnormal_ion_homeostasis	0.92546177
43	MP0004859_abnormal_synaptic_plasticity	0.90566717
44	MP0003329_amyloid_beta_deposits	0.89110099
45	MP0005375_adipose_tissue_phenotype	0.88645370
46	MP0000681_abnormal_thyroid_gland	0.88193577
47	MP0003091_abnormal_cell_migration	0.86011696
48	MP0003453_abnormal_keratinocyte_physiol	0.85435187
49	MP0005166_decreased_susceptibility_to	0.84357315
50	MP0001145_abnormal_male_reproductive	0.83528376
51	MP0005025_abnormal_response_to	0.82605814
52	MP0009785_altered_susceptibility_to	0.81576809
53	MP0002998_abnormal_bone_remodeling	0.81519200
54	MP0000343_altered_response_to	0.80826502
55	MP0000858_altered_metastatic_potential	0.80342669
56	MP0002653_abnormal_ependyma_morphology	0.79216921
57	MP0002139_abnormal_hepatobiliary_system	0.78606769
58	MP0005379_endocrine/exocrine_gland_phen	0.78408757
59	MP0000653_abnormal_sex_gland	0.76073715
60	MP0001545_abnormal_hematopoietic_system	0.75036209
61	MP0005397_hematopoietic_system_phenotyp	0.75036209
62	MP0000249_abnormal_blood_vessel	0.73789928
63	MP0005167_abnormal_blood-brain_barrier	0.69270992
64	MP0003879_abnormal_hair_cell	0.69058620
65	MP0005390_skeleton_phenotype	0.68844336
66	MP0005623_abnormal_meninges_morphology	0.68344253
67	MP0002127_abnormal_cardiovascular_syste	0.67099054
68	MP0000566_synostosis	0.66951291
69	MP0003646_muscle_fatigue	0.63926750
70	MP0000049_abnormal_middle_ear	0.63580860
71	MP0004742_abnormal_vestibular_system	0.63170933
72	MP0005076_abnormal_cell_differentiation	0.63024545
73	MP0005023_abnormal_wound_healing	0.62341562
74	MP0008004_abnormal_stomach_pH	0.60599052
75	MP0002452_abnormal_antigen_presenting	0.58826406
76	MP0009115_abnormal_fat_cell	0.58451034
77	MP0004883_abnormal_blood_vessel	0.57737859
78	MP0000613_abnormal_salivary_gland	0.57606371
79	MP0003011_delayed_dark_adaptation	0.57272401
80	MP0000733_abnormal_muscle_development	0.56549799
81	MP0000955_abnormal_spinal_cord	0.56060893
82	MP0009840_abnormal_foam_cell	0.56023368
83	MP0003718_maternal_effect	0.55845678
84	MP0004085_abnormal_heartbeat	0.55808899
85	MP0002723_abnormal_immune_serum	0.54208177
86	MP0005647_abnormal_sex_gland	0.53442871
87	MP0001790_abnormal_immune_system	0.52554496
88	MP0005387_immune_system_phenotype	0.52554496
89	MP0004084_abnormal_cardiac_muscle	0.52552244
90	MP0002733_abnormal_thermal_nociception	0.50877607
91	MP0005595_abnormal_vascular_smooth	0.50538871
92	MP0000026_abnormal_inner_ear	0.50237145
93	MP0001963_abnormal_hearing_physiology	0.49174224
94	MP0001905_abnormal_dopamine_level	0.48842197
95	MP0008469_abnormal_protein_level	0.48739870
96	MP0000470_abnormal_stomach_morphology	0.46812737
97	MP0005423_abnormal_somatic_nervous	0.46543429
98	MP0005636_abnormal_mineral_homeostasis	0.46079316
99	MP0001486_abnormal_startle_reflex	0.43735588
100	MP0004484_altered_response_of	0.43557329

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.46606371
2	Asymmetric septal hypertrophy (HP:0001670)	5.62687367
3	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	5.24401702
4	Focal segmental glomerulosclerosis (HP:0000097)	4.32267678
5	Bell-shaped thorax (HP:0001591)	4.04352317
6	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.82781208
7	Absent/shortened dynein arms (HP:0200106)	3.82781208
8	Nasal polyposis (HP:0100582)	3.82093724
9	Bony spicule pigmentary retinopathy (HP:0007737)	3.61592946
10	Hyperkalemia (HP:0002153)	3.53757237
11	Male infertility (HP:0003251)	3.41966621
12	Glomerulosclerosis (HP:0000096)	3.40322068
13	Distal upper limb amyotrophy (HP:0007149)	3.39023363
14	Upper limb amyotrophy (HP:0009129)	3.39023363
15	Hypochromic microcytic anemia (HP:0004840)	3.37581173
16	Facial shape deformation (HP:0011334)	3.34771637
17	Potter facies (HP:0002009)	3.34771637
18	Hypoplastic ischia (HP:0003175)	3.29017464
19	Tubulointerstitial nephritis (HP:0001970)	3.28959758
20	Cone-rod dystrophy (HP:0000548)	3.23994063
21	Abnormality of the nasal mucosa (HP:0000433)	3.13379273
22	Infertility (HP:0000789)	3.11275812
23	Resting tremor (HP:0002322)	3.09729541
24	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.96910004
25	Attenuation of retinal blood vessels (HP:0007843)	2.96419515
26	Abnormality of macular pigmentation (HP:0008002)	2.86669273
27	Enlarged epiphyses (HP:0010580)	2.85436611
28	Stage 5 chronic kidney disease (HP:0003774)	2.83417618
29	Abnormality of the ischium (HP:0003174)	2.82967806
30	Easy fatigability (HP:0003388)	2.81817503
31	Distal lower limb amyotrophy (HP:0008944)	2.81184370
32	Arterial tortuosity (HP:0005116)	2.76950350
33	Unilateral renal agenesis (HP:0000122)	2.74294429
34	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.73500251
35	Impulsivity (HP:0100710)	2.71579160
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.70562678
37	Axonal loss (HP:0003447)	2.65730338
38	Abnormal ciliary motility (HP:0012262)	2.49975818
39	Abnormal respiratory motile cilium physiology (HP:0012261)	2.45911088
40	Abnormal respiratory epithelium morphology (HP:0012253)	2.44948155
41	Abnormal respiratory motile cilium morphology (HP:0005938)	2.44948155
42	Hypoplasia of the thymus (HP:0000778)	2.43913860
43	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.43078021
44	Abnormality of the aortic arch (HP:0012303)	2.42283952
45	Gastrointestinal infarctions (HP:0005244)	2.41981717
46	Glucose intolerance (HP:0000833)	2.37151629
47	Vascular tortuosity (HP:0004948)	2.36047803
48	Flattened epiphyses (HP:0003071)	2.35070792
49	Postural instability (HP:0002172)	2.32951524
50	Abnormal spermatogenesis (HP:0008669)	2.32192835
51	Reticulocytosis (HP:0001923)	2.26347490
52	Ectopia lentis (HP:0001083)	2.23880643
53	Ventricular tachycardia (HP:0004756)	2.22469769
54	Gingivitis (HP:0000230)	2.21627819
55	Abnormality of macrophages (HP:0004311)	2.18549523
56	Spondylolisthesis (HP:0003302)	2.16957252
57	Atrophic scars (HP:0001075)	2.16387193
58	Epiphyseal dysplasia (HP:0002656)	2.15485979
59	Atelectasis (HP:0100750)	2.12116025
60	Bowel incontinence (HP:0002607)	2.10919296
61	Azoospermia (HP:0000027)	2.10348837
62	Progressive sensorineural hearing impairment (HP:0000408)	2.07884426
63	Tubular atrophy (HP:0000092)	2.02856020
64	Hypochromic anemia (HP:0001931)	2.02179211
65	Protuberant abdomen (HP:0001538)	2.01112277
66	Increased purine levels (HP:0004368)	1.99579153
67	Hyperuricemia (HP:0002149)	1.99579153
68	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.98756737
69	Absent epiphyses (HP:0010577)	1.98756737
70	Hyperthyroidism (HP:0000836)	1.97781931
71	Hyponatremia (HP:0002902)	1.96752057
72	Vertebral clefting (HP:0008428)	1.93028438
73	Abnormality of the costochondral junction (HP:0000919)	1.92951360
74	Subcapsular cataract (HP:0000523)	1.92570447
75	Abnormal large intestine physiology (HP:0012700)	1.91708594
76	Abnormal urine output (HP:0012590)	1.88841641
77	Recurrent pneumonia (HP:0006532)	1.87305433
78	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.85790106
79	Thin bony cortex (HP:0002753)	1.84598244
80	Abnormality of dental color (HP:0011073)	1.84451176
81	Broad face (HP:0000283)	1.83433322
82	Poikilocytosis (HP:0004447)	1.82253340
83	Abnormality of renal excretion (HP:0011036)	1.80847405
84	Amelogenesis imperfecta (HP:0000705)	1.78490812
85	Prolonged neonatal jaundice (HP:0006579)	1.78046753
86	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.77599574
87	Hand muscle atrophy (HP:0009130)	1.76553372
88	Spastic paraparesis (HP:0002313)	1.75908361
89	Truncus arteriosus (HP:0001660)	1.75710722
90	Renal dysplasia (HP:0000110)	1.74587544
91	Peritonitis (HP:0002586)	1.74502162
92	Slow saccadic eye movements (HP:0000514)	1.73110017
93	Widely patent fontanelles and sutures (HP:0004492)	1.70645493
94	Obstructive lung disease (HP:0006536)	1.69109510
95	Chronic obstructive pulmonary disease (HP:0006510)	1.69109510
96	Cellulitis (HP:0100658)	1.68791691
97	Polar cataract (HP:0010696)	1.68540786
98	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.67164371
99	Abnormality of chloride homeostasis (HP:0011422)	1.66959967
100	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.65989090

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	4.97938398
2	TESK1	4.74693128
3	MST1R	4.69955684
4	EPHA2	4.69293591
5	DDR2	4.47845326
6	SIK1	2.67867196
7	STK38	2.52815310
8	LMTK2	2.29691072
9	TESK2	2.29400713
10	ERN1	2.05681810
11	MAP3K9	1.90672839
12	SIK2	1.72572818
13	MAPK15	1.69642111
14	PDPK1	1.58647037
15	MET	1.57700788
16	ICK	1.46009886
17	CAMK1G	1.43187721
18	INSRR	1.34412470
19	MARK2	1.31674986
20	MAP3K7	1.29611157
21	PDK1	1.28718512
22	STK16	1.28204602
23	MAP3K11	1.27577475
24	TRIB3	1.23296627
25	PLK2	1.20671425
26	NTRK1	1.19181016
27	PTK2B	1.18900429
28	PTK6	1.17502247
29	RIPK4	1.15516730
30	MAP4K1	1.12165317
31	WNK1	1.11699568
32	IRAK3	1.11210046
33	RPS6KA2	1.08261982
34	CDK7	1.05649741
35	DYRK1B	1.02248234
36	PRKG2	1.01678618
37	BMX	1.01004083
38	EPHB1	0.95117351
39	TNK2	0.94367219
40	RPS6KL1	0.93378119
41	RPS6KC1	0.93378119
42	CAMK1D	0.91769262
43	BRD4	0.90719368
44	EPHB2	0.90182203
45	JAK3	0.86248177
46	MAP3K2	0.85445751
47	KSR2	0.84178380
48	PNCK	0.83435265
49	MAP3K13	0.78316441
50	RPS6KA6	0.78114760
51	CDK8	0.76998422
52	MAP3K3	0.76211861
53	MTOR	0.75739578
54	PRKD3	0.75333042
55	MAP3K1	0.73561001
56	BRAF	0.71000219
57	MAP3K8	0.70864528
58	CDK12	0.69849592
59	RPS6KA1	0.68540693
60	PTK2	0.67710573
61	TAOK1	0.62313483
62	ARAF	0.61253139
63	MARK3	0.58991731
64	ZAP70	0.58565574
65	MAP4K2	0.57164077
66	IKBKB	0.56711683
67	CHUK	0.56094519
68	MUSK	0.53713280
69	CSK	0.51388609
70	PIK3CG	0.47594997
71	PDGFRA	0.47511639
72	PRKCZ	0.45324507
73	FGFR4	0.45241156
74	HIPK2	0.44988410
75	TYRO3	0.43222635
76	ROCK1	0.43116383
77	CDK4	0.42784135
78	MAPK8	0.42269637
79	BTK	0.42228895
80	CDC42BPA	0.41706930
81	NEK6	0.41687376
82	MAP2K2	0.40631862
83	PRKAA2	0.40039340
84	PKN2	0.39630748
85	BLK	0.39146171
86	RIPK1	0.39025249
87	MAPK1	0.38968624
88	CAMK1	0.38890902
89	MAP2K3	0.38321935
90	LATS2	0.36235819
91	PRKG1	0.35189681
92	TBK1	0.34683997
93	GRK6	0.34191227
94	PRPF4B	0.33268340
95	ROCK2	0.32251651
96	MATK	0.30485704
97	NME2	0.29727822
98	IRAK4	0.29435738
99	CSF1R	0.29349843
100	GSK3B	0.26893982

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	4.43146566
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.64238775
3	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.57095099
4	Notch signaling pathway_Homo sapiens_hsa04330	2.11286061
5	Olfactory transduction_Homo sapiens_hsa04740	1.96313419
6	Acute myeloid leukemia_Homo sapiens_hsa05221	1.93510883
7	Allograft rejection_Homo sapiens_hsa05330	1.88321697
8	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.84692323
9	Graft-versus-host disease_Homo sapiens_hsa05332	1.75559090
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.70570033
11	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.66456696
12	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.56955878
13	Endocytosis_Homo sapiens_hsa04144	1.56265041
14	Type II diabetes mellitus_Homo sapiens_hsa04930	1.52656722
15	Osteoclast differentiation_Homo sapiens_hsa04380	1.46083316
16	Type I diabetes mellitus_Homo sapiens_hsa04940	1.39484184
17	Influenza A_Homo sapiens_hsa05164	1.37773586
18	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.31240932
19	African trypanosomiasis_Homo sapiens_hsa05143	1.30988847
20	VEGF signaling pathway_Homo sapiens_hsa04370	1.28861860
21	Malaria_Homo sapiens_hsa05144	1.28579508
22	Antigen processing and presentation_Homo sapiens_hsa04612	1.27791273
23	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.26113893
24	Leishmaniasis_Homo sapiens_hsa05140	1.22046189
25	Viral myocarditis_Homo sapiens_hsa05416	1.21024554
26	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.16833592
27	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.16062942
28	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.15226903
29	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.14885533
30	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.13352535
31	Toxoplasmosis_Homo sapiens_hsa05145	1.13274937
32	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.06419428
33	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.03800080
34	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.97985158
35	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.95875805
36	Other glycan degradation_Homo sapiens_hsa00511	0.94307740
37	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.93890476
38	Pancreatic cancer_Homo sapiens_hsa05212	0.93575900
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.93311738
40	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.91881626
41	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.90751358
42	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.89986508
43	TNF signaling pathway_Homo sapiens_hsa04668	0.86630481
44	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.85102834
45	ECM-receptor interaction_Homo sapiens_hsa04512	0.83320320
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.82111753
47	Salivary secretion_Homo sapiens_hsa04970	0.78477303
48	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.78222783
49	Galactose metabolism_Homo sapiens_hsa00052	0.76737301
50	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.76118675
51	Chemokine signaling pathway_Homo sapiens_hsa04062	0.76115754
52	Prolactin signaling pathway_Homo sapiens_hsa04917	0.75817336
53	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.74836670
54	mTOR signaling pathway_Homo sapiens_hsa04150	0.74747736
55	Protein digestion and absorption_Homo sapiens_hsa04974	0.73852551
56	Renal cell carcinoma_Homo sapiens_hsa05211	0.73723531
57	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.72423541
58	MAPK signaling pathway_Homo sapiens_hsa04010	0.72178282
59	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.70226653
60	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.70027748
61	Insulin resistance_Homo sapiens_hsa04931	0.69860895
62	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.69856104
63	Insulin signaling pathway_Homo sapiens_hsa04910	0.66224063
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.66031754
65	Bladder cancer_Homo sapiens_hsa05219	0.65791832
66	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.65642331
67	Herpes simplex infection_Homo sapiens_hsa05168	0.64850145
68	Choline metabolism in cancer_Homo sapiens_hsa05231	0.63939959
69	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.63493140
70	Adherens junction_Homo sapiens_hsa04520	0.62651491
71	Non-small cell lung cancer_Homo sapiens_hsa05223	0.61378861
72	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.61031817
73	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.60347912
74	Estrogen signaling pathway_Homo sapiens_hsa04915	0.59562124
75	Tuberculosis_Homo sapiens_hsa05152	0.57965253
76	Focal adhesion_Homo sapiens_hsa04510	0.57189782
77	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.55836023
78	Phenylalanine metabolism_Homo sapiens_hsa00360	0.55642046
79	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.54844954
80	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.54112207
81	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.54102486
82	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.53939232
83	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.53814954
84	Measles_Homo sapiens_hsa05162	0.53690996
85	Viral carcinogenesis_Homo sapiens_hsa05203	0.52718482
86	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.52496113
87	Amoebiasis_Homo sapiens_hsa05146	0.52260511
88	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.50260151
89	Tight junction_Homo sapiens_hsa04530	0.50102785
90	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.49074957
91	FoxO signaling pathway_Homo sapiens_hsa04068	0.48527293
92	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.46899343
93	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.46863271
94	ABC transporters_Homo sapiens_hsa02010	0.45440279
95	MicroRNAs in cancer_Homo sapiens_hsa05206	0.44825865
96	ErbB signaling pathway_Homo sapiens_hsa04012	0.44241917
97	PPAR signaling pathway_Homo sapiens_hsa03320	0.43501962
98	Hepatitis B_Homo sapiens_hsa05161	0.41305164
99	Legionellosis_Homo sapiens_hsa05134	0.40305554
100	HTLV-I infection_Homo sapiens_hsa05166	0.39692203

TBC1D3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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