TBC1D30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.21566591
2synaptic vesicle maturation (GO:0016188)6.08352337
3locomotory exploration behavior (GO:0035641)5.76907639
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.58117022
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.43797263
6regulation of synaptic vesicle exocytosis (GO:2000300)5.38797200
7glutamate secretion (GO:0014047)5.28078677
8synaptic vesicle exocytosis (GO:0016079)5.26759558
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.24885836
10vocalization behavior (GO:0071625)5.22391279
11atrial cardiac muscle cell action potential (GO:0086014)5.17385118
12kidney morphogenesis (GO:0060993)4.96054609
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.86524990
14regulation of synaptic vesicle transport (GO:1902803)4.79603590
15regulation of glutamate receptor signaling pathway (GO:1900449)4.69445105
16neurotransmitter secretion (GO:0007269)4.47687567
17urinary tract smooth muscle contraction (GO:0014848)4.46300036
18protein localization to synapse (GO:0035418)4.43201123
19regulation of neuronal synaptic plasticity (GO:0048168)4.28764344
20neuronal action potential propagation (GO:0019227)4.25956034
21exploration behavior (GO:0035640)4.23984903
22ionotropic glutamate receptor signaling pathway (GO:0035235)4.22434572
23regulation of synapse structural plasticity (GO:0051823)4.19876604
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.18513085
25behavioral response to nicotine (GO:0035095)4.16871003
26layer formation in cerebral cortex (GO:0021819)4.09159606
27neuron cell-cell adhesion (GO:0007158)4.07800109
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.02207888
29regulation of respiratory system process (GO:0044065)3.98590823
30regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.97692443
31neurotransmitter-gated ion channel clustering (GO:0072578)3.97058135
32synaptic transmission, glutamatergic (GO:0035249)3.93977215
33dendritic spine morphogenesis (GO:0060997)3.90580365
34peristalsis (GO:0030432)3.83946360
35pseudouridine synthesis (GO:0001522)3.82931855
36gamma-aminobutyric acid transport (GO:0015812)3.79687650
37positive regulation of membrane potential (GO:0045838)3.76985699
38protein polyglutamylation (GO:0018095)3.76313248
39cellular potassium ion homeostasis (GO:0030007)3.75540268
40long-term memory (GO:0007616)3.72592806
41neuron-neuron synaptic transmission (GO:0007270)3.70225988
42glutamate receptor signaling pathway (GO:0007215)3.68842305
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.64683862
44activation of protein kinase A activity (GO:0034199)3.62131445
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59147689
46proline transport (GO:0015824)3.58823157
47regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.58796347
48neurotransmitter transport (GO:0006836)3.57409608
49cerebellar Purkinje cell differentiation (GO:0021702)3.56657598
50pyrimidine nucleobase catabolic process (GO:0006208)3.49297700
51positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.46579676
52regulation of postsynaptic membrane potential (GO:0060078)3.45381717
53regulation of neurotransmitter secretion (GO:0046928)3.41731215
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.38459841
55regulation of synaptic plasticity (GO:0048167)3.37752414
56glycerophospholipid catabolic process (GO:0046475)3.36614114
57positive regulation of guanylate cyclase activity (GO:0031284)3.36465094
58sodium ion export (GO:0071436)3.34960898
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32348181
60nucleobase catabolic process (GO:0046113)3.31792701
61dendrite morphogenesis (GO:0048813)3.30254617
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.28826954
63auditory behavior (GO:0031223)3.28508073
64regulation of neurotransmitter levels (GO:0001505)3.28457735
65neuromuscular process controlling balance (GO:0050885)3.28225440
66positive regulation of CREB transcription factor activity (GO:0032793)3.28202821
67positive regulation of neurotransmitter transport (GO:0051590)3.27257327
68regulation of microtubule-based movement (GO:0060632)3.26945567
69postsynaptic membrane organization (GO:0001941)3.26747291
70nitric oxide biosynthetic process (GO:0006809)3.25753027
71positive regulation of neurotransmitter secretion (GO:0001956)3.24893643
72regulation of ARF protein signal transduction (GO:0032012)3.23796872
73response to auditory stimulus (GO:0010996)3.22697827
74regulation of dendritic spine morphogenesis (GO:0061001)3.22212907
75regulation of vesicle fusion (GO:0031338)3.19601402
76negative regulation of telomere maintenance (GO:0032205)3.18785252
77adult feeding behavior (GO:0008343)3.18531518
78glycine transport (GO:0015816)3.18296124
79transmission of nerve impulse (GO:0019226)3.18045102
80regulation of synaptic transmission, glutamatergic (GO:0051966)3.16857555
81neuromuscular process controlling posture (GO:0050884)3.16457377
82cell communication by electrical coupling (GO:0010644)3.16190550
83regulation of neurotransmitter transport (GO:0051588)3.15676302
84antigen processing and presentation via MHC class Ib (GO:0002475)3.14904333
85cellular ketone body metabolic process (GO:0046950)3.14597375
86regulation of respiratory gaseous exchange (GO:0043576)3.13230884
87prepulse inhibition (GO:0060134)3.13206365
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13196435
89long-term synaptic potentiation (GO:0060291)3.12532476
90neuron recognition (GO:0008038)3.12239323
91membrane hyperpolarization (GO:0060081)3.08987396
92positive regulation of synapse maturation (GO:0090129)3.08904599
93regulation of telomere maintenance (GO:0032204)3.08815969
94myotube differentiation (GO:0014902)3.08667206
95positive regulation of respiratory burst (GO:0060267)3.07157733
96synaptic vesicle endocytosis (GO:0048488)3.05156093
97negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03666266
98regulation of guanylate cyclase activity (GO:0031282)3.03181810
99presynaptic membrane assembly (GO:0097105)3.02552992
100G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99531044
101neuronal ion channel clustering (GO:0045161)2.99237385
102chemosensory behavior (GO:0007635)2.99131813
103detection of light stimulus involved in sensory perception (GO:0050962)2.98673577
104detection of light stimulus involved in visual perception (GO:0050908)2.98673577
105DNA deamination (GO:0045006)2.95543814
106dendritic spine organization (GO:0097061)2.94413106
107vesicle transport along microtubule (GO:0047496)2.92289233
108membrane depolarization (GO:0051899)2.91886157
109membrane depolarization during action potential (GO:0086010)2.89968542
110positive regulation of synaptic transmission (GO:0050806)2.89762641
111epithelial cilium movement (GO:0003351)2.89731028
112gamma-aminobutyric acid signaling pathway (GO:0007214)2.89683778
113positive regulation of sodium ion transmembrane transport (GO:1902307)2.88451253
114axonal fasciculation (GO:0007413)2.87870733
115neuronal action potential (GO:0019228)2.87549671
116innervation (GO:0060384)2.86870125
117synapse assembly (GO:0007416)2.86313507
118fucose catabolic process (GO:0019317)2.85842228
119L-fucose metabolic process (GO:0042354)2.85842228
120L-fucose catabolic process (GO:0042355)2.85842228
121serotonin metabolic process (GO:0042428)2.85119298
122piRNA metabolic process (GO:0034587)2.84798828
123sulfate transport (GO:0008272)2.84558071
124presynaptic membrane organization (GO:0097090)2.84017896
125regulation of synaptic transmission (GO:0050804)2.83599517
126learning (GO:0007612)2.81887897
127regulation of calcium ion-dependent exocytosis (GO:0017158)2.78789520
128negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78715628
129neuromuscular process (GO:0050905)2.78418592
130synaptic transmission (GO:0007268)2.78356463
131positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77620777
132ketone body metabolic process (GO:1902224)2.77208091
133negative regulation of interleukin-1 beta production (GO:0032691)2.76993280
134regulation of dendritic spine development (GO:0060998)2.76876312
135regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.76415094
136primary amino compound metabolic process (GO:1901160)2.76210107
137phasic smooth muscle contraction (GO:0014821)2.76005666
138positive regulation of dendritic spine development (GO:0060999)2.75954854
139L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.75783905
140regulation of synapse assembly (GO:0051963)2.74914719
141cell migration in hindbrain (GO:0021535)2.74666745
142social behavior (GO:0035176)2.74499881
143intraspecies interaction between organisms (GO:0051703)2.74499881
144G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73078373
145positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.71914522
146cilium movement (GO:0003341)2.70110722
147growth hormone secretion (GO:0030252)2.69418918
148cornea development in camera-type eye (GO:0061303)2.67346669
149sympathetic nervous system development (GO:0048485)2.62372371
150nonmotile primary cilium assembly (GO:0035058)2.60988803
151preassembly of GPI anchor in ER membrane (GO:0016254)2.59641604
152water-soluble vitamin biosynthetic process (GO:0042364)2.58605916
153regulation of neurotransmitter uptake (GO:0051580)2.54347448
154action potential (GO:0001508)2.53696905
155multicellular organismal movement (GO:0050879)2.53657412
156musculoskeletal movement (GO:0050881)2.53657412
157detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52677431
158response to nitrosative stress (GO:0051409)2.52256635
159protein localization to cilium (GO:0061512)2.52242408
160neuron fate specification (GO:0048665)2.50042513
161regulation of action potential (GO:0098900)2.48644828
162startle response (GO:0001964)2.45553768
163gap junction assembly (GO:0016264)2.45182574
164axoneme assembly (GO:0035082)2.45106090
165peptidyl-cysteine modification (GO:0018198)2.44745298
166insulin secretion (GO:0030073)2.44331244
167positive regulation of synapse assembly (GO:0051965)2.42557188
168biotin metabolic process (GO:0006768)2.38909836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.42634817
2GBX2_23144817_ChIP-Seq_PC3_Human3.21526718
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97920029
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95320188
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85067892
6DROSHA_22980978_ChIP-Seq_HELA_Human2.67008410
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65290161
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65290161
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.64835346
10* RARB_27405468_Chip-Seq_BRAIN_Mouse2.60058775
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58872577
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53171115
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51555578
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.46574828
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45183055
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35923490
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35289828
18GATA1_22025678_ChIP-Seq_K562_Human2.30311195
19* EZH2_27304074_Chip-Seq_ESCs_Mouse2.29275202
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26988258
21ER_23166858_ChIP-Seq_MCF-7_Human2.23915077
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.23808915
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.19394636
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.12067624
25FUS_26573619_Chip-Seq_HEK293_Human2.07411298
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.02385700
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99900529
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96391277
29VDR_22108803_ChIP-Seq_LS180_Human1.96365642
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95567813
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91280211
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.87725514
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85602571
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83701298
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.79627141
36AR_21572438_ChIP-Seq_LNCaP_Human1.79005898
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74669735
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.58579384
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57529370
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53753733
41SMAD4_21799915_ChIP-Seq_A2780_Human1.53285808
42ESR1_21235772_ChIP-Seq_MCF-7_Human1.52365505
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46069375
44TP53_22573176_ChIP-Seq_HFKS_Human1.44687344
45EWS_26573619_Chip-Seq_HEK293_Human1.43992799
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43582165
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37291203
48CBP_20019798_ChIP-Seq_JUKART_Human1.37291203
49TAF15_26573619_Chip-Seq_HEK293_Human1.36928275
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36375177
51TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34898823
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34450185
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33970120
54SMAD4_21741376_ChIP-Seq_EPCs_Human1.33543443
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33364942
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31027981
57HOXB7_26014856_ChIP-Seq_BT474_Human1.30339729
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30226776
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.29448171
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29039466
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28102231
62* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26956729
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26891344
64AR_19668381_ChIP-Seq_PC3_Human1.26698474
65* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26164418
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26003088
67KDM2B_26808549_Chip-Seq_K562_Human1.24077290
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21382071
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.21150703
70STAT3_23295773_ChIP-Seq_U87_Human1.21050663
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20360959
72ZNF274_21170338_ChIP-Seq_K562_Hela1.18058398
73AHR_22903824_ChIP-Seq_MCF-7_Human1.17379310
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.16608133
75P300_19829295_ChIP-Seq_ESCs_Human1.16249232
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.15916760
77PIAS1_25552417_ChIP-Seq_VCAP_Human1.15286936
78AR_25329375_ChIP-Seq_VCAP_Human1.15278904
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.14529926
80TCF4_22108803_ChIP-Seq_LS180_Human1.14069780
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.13652307
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13334910
83ERA_21632823_ChIP-Seq_H3396_Human1.12248932
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12043816
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11263639
86* RING1B_27294783_Chip-Seq_NPCs_Mouse1.11038209
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10308838
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09970337
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.09354406
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08746345
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07859516
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07684425
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.07412061
94FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07412061
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07384917
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04790121
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04483296
98OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04376066
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04236682
100* FLI1_21867929_ChIP-Seq_TH2_Mouse1.03675122
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03613184
102YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03194248
103TCF4_23295773_ChIP-Seq_U87_Human1.02832434
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02613940
105NOTCH1_21737748_ChIP-Seq_TLL_Human1.02538759
106CBX2_27304074_Chip-Seq_ESCs_Mouse1.02349065
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01008267
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00749963
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00688510
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00474631
111BCAT_22108803_ChIP-Seq_LS180_Human1.00426201
112SMAD4_21741376_ChIP-Seq_HESCs_Human1.00002224
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99735045
114ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99352170
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97248050
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96645676
117IRF1_19129219_ChIP-ChIP_H3396_Human0.95895622
118FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95805913
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95173383
120MYC_19829295_ChIP-Seq_ESCs_Human0.94748313
121BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94532057
122SMAD3_21741376_ChIP-Seq_ESCs_Human0.93156076
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.91886969
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90790173
125RUNX2_22187159_ChIP-Seq_PCA_Human0.90123989
126* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89902854
127RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89491034
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.89403072
129TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88373314
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87937723
131* RNF2_27304074_Chip-Seq_NSC_Mouse0.87868384
132ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86669063
133PRDM14_20953172_ChIP-Seq_ESCs_Human0.86068554
134RXR_22108803_ChIP-Seq_LS180_Human0.85189797
135TP53_16413492_ChIP-PET_HCT116_Human0.84139315
136CTCF_27219007_Chip-Seq_Bcells_Human0.83368976
137IGF1R_20145208_ChIP-Seq_DFB_Human0.83353142
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83327733
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82336339
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81629753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.45491467
2MP0003880_abnormal_central_pattern4.24679948
3MP0004147_increased_porphyrin_level4.11402072
4MP0003635_abnormal_synaptic_transmissio4.08832790
5MP0004270_analgesia3.78973277
6MP0009745_abnormal_behavioral_response3.31777570
7MP0002063_abnormal_learning/memory/cond3.25184308
8MP0002822_catalepsy3.10572634
9MP0002064_seizures3.04634002
10MP0005423_abnormal_somatic_nervous2.95921278
11MP0009046_muscle_twitch2.90849561
12MP0001968_abnormal_touch/_nociception2.81429227
13MP0002837_dystrophic_cardiac_calcinosis2.80820850
14MP0002572_abnormal_emotion/affect_behav2.72288971
15MP0009780_abnormal_chondrocyte_physiolo2.67931538
16MP0001486_abnormal_startle_reflex2.65734819
17MP0002734_abnormal_mechanical_nocicepti2.62082437
18MP0001348_abnormal_lacrimal_gland2.61229818
19MP0002272_abnormal_nervous_system2.53473042
20MP0001501_abnormal_sleep_pattern2.25727042
21MP0003646_muscle_fatigue2.21854328
22MP0002909_abnormal_adrenal_gland2.09000924
23MP0002733_abnormal_thermal_nociception2.08942935
24MP0001440_abnormal_grooming_behavior2.04981582
25MP0005646_abnormal_pituitary_gland2.00585756
26MP0002736_abnormal_nociception_after2.00050983
27MP0002735_abnormal_chemical_nociception1.98642333
28MP0003195_calcinosis1.95277868
29MP0001970_abnormal_pain_threshold1.94739249
30MP0003879_abnormal_hair_cell1.92331524
31MP0002557_abnormal_social/conspecific_i1.86873583
32MP0008569_lethality_at_weaning1.86778103
33MP0008877_abnormal_DNA_methylation1.86466260
34MP0002067_abnormal_sensory_capabilities1.85046793
35MP0004811_abnormal_neuron_physiology1.81303103
36MP0000427_abnormal_hair_cycle1.77679640
37MP0001984_abnormal_olfaction1.76531235
38MP0004858_abnormal_nervous_system1.75824568
39MP0004885_abnormal_endolymph1.72141094
40MP0002184_abnormal_innervation1.72098396
41MP0003329_amyloid_beta_deposits1.71164407
42MP0004924_abnormal_behavior1.67478467
43MP0005386_behavior/neurological_phenoty1.67478467
44MP0000778_abnormal_nervous_system1.64362963
45MP0001502_abnormal_circadian_rhythm1.58741221
46MP0000383_abnormal_hair_follicle1.57323418
47MP0006276_abnormal_autonomic_nervous1.50948443
48MP0000955_abnormal_spinal_cord1.50821909
49MP0005645_abnormal_hypothalamus_physiol1.50717045
50MP0004133_heterotaxia1.45925913
51MP0002102_abnormal_ear_morphology1.43861745
52MP0002882_abnormal_neuron_morphology1.42043991
53MP0003633_abnormal_nervous_system1.39508614
54MP0000569_abnormal_digit_pigmentation1.38032840
55MP0002066_abnormal_motor_capabilities/c1.36441025
56MP0003137_abnormal_impulse_conducting1.34522029
57MP0005551_abnormal_eye_electrophysiolog1.31780380
58MP0008961_abnormal_basal_metabolism1.31156915
59MP0003787_abnormal_imprinting1.29886174
60MP0003890_abnormal_embryonic-extraembry1.24216368
61MP0005379_endocrine/exocrine_gland_phen1.22684444
62MP0008875_abnormal_xenobiotic_pharmacok1.19696962
63MP0010386_abnormal_urinary_bladder1.18695720
64MP0010678_abnormal_skin_adnexa1.17354676
65MP0009840_abnormal_foam_cell1.12606637
66MP0002229_neurodegeneration1.11251750
67MP0004742_abnormal_vestibular_system1.09813839
68MP0003631_nervous_system_phenotype1.08162712
69MP0001177_atelectasis1.08070324
70MP0005394_taste/olfaction_phenotype1.07149141
71MP0005499_abnormal_olfactory_system1.07149141
72MP0004043_abnormal_pH_regulation1.06418541
73MP0000013_abnormal_adipose_tissue1.04938903
74MP0003283_abnormal_digestive_organ1.04843823
75MP0001529_abnormal_vocalization1.00255428
76MP0002160_abnormal_reproductive_system0.99404525
77MP0002152_abnormal_brain_morphology0.99257383
78MP0008872_abnormal_physiological_respon0.99228888
79MP0002751_abnormal_autonomic_nervous0.97788650
80MP0002069_abnormal_eating/drinking_beha0.97314813
81MP0005535_abnormal_body_temperature0.96304458
82MP0001905_abnormal_dopamine_level0.95851239
83MP0003183_abnormal_peptide_metabolism0.94982557
84MP0005448_abnormal_energy_balance0.94312011
85MP0004142_abnormal_muscle_tone0.92682883
86MP0001944_abnormal_pancreas_morphology0.90230932
87MP0003075_altered_response_to0.89941806
88MP0008874_decreased_physiological_sensi0.88322891
89MP0001188_hyperpigmentation0.86016480
90MP0005248_abnormal_Harderian_gland0.85287454
91MP0003690_abnormal_glial_cell0.84816473
92MP0003122_maternal_imprinting0.84711748
93MP0001664_abnormal_digestion0.82939820
94MP0002090_abnormal_vision0.82861435
95MP0006072_abnormal_retinal_apoptosis0.80981904
96MP0000604_amyloidosis0.80102403
97MP0003634_abnormal_glial_cell0.78460595
98MP0002254_reproductive_system_inflammat0.77945683
99MP0001919_abnormal_reproductive_system0.77820351
100MP0000230_abnormal_systemic_arterial0.77761166
101MP0000631_abnormal_neuroendocrine_gland0.77621576
102MP0002638_abnormal_pupillary_reflex0.76218169
103MP0003718_maternal_effect0.75847474
104MP0001963_abnormal_hearing_physiology0.75648064
105MP0004085_abnormal_heartbeat0.75263882
106MP0001485_abnormal_pinna_reflex0.73274267
107MP0002752_abnormal_somatic_nervous0.72602906
108MP0003953_abnormal_hormone_level0.71590634
109MP0005195_abnormal_posterior_eye0.70900730
110MP0004782_abnormal_surfactant_physiolog0.70892074
111MP0003121_genomic_imprinting0.70796647
112MP0002078_abnormal_glucose_homeostasis0.70582455
113MP0003632_abnormal_nervous_system0.67487447
114MP0002876_abnormal_thyroid_physiology0.67194330
115MP0004145_abnormal_muscle_electrophysio0.67007505
116MP0005253_abnormal_eye_physiology0.66921216
117MP0010234_abnormal_vibrissa_follicle0.66892009
118MP0000920_abnormal_myelination0.64248039
119MP0003172_abnormal_lysosome_physiology0.61178304
120MP0005187_abnormal_penis_morphology0.59696346
121MP0005167_abnormal_blood-brain_barrier0.59409595
122MP0002693_abnormal_pancreas_physiology0.50936988
123MP0001765_abnormal_ion_homeostasis0.50549471
124MP0001943_abnormal_respiration0.49355085
125MP0003956_abnormal_body_size0.49302969
126MP0010769_abnormal_survival0.49143049
127MP0005409_darkened_coat_color0.48800909
128MP0002082_postnatal_lethality0.48473907
129MP0010770_preweaning_lethality0.48473907
130MP0001299_abnormal_eye_distance/0.48301875

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)7.25973994
2Focal motor seizures (HP:0011153)7.09130566
3Myokymia (HP:0002411)6.88023824
4Focal seizures (HP:0007359)5.51011841
5Visual hallucinations (HP:0002367)5.10416557
6Epileptic encephalopathy (HP:0200134)4.62577953
7Breast hypoplasia (HP:0003187)4.42311827
8Atonic seizures (HP:0010819)4.25943328
9Febrile seizures (HP:0002373)4.23804097
10Progressive cerebellar ataxia (HP:0002073)4.02977318
11Action tremor (HP:0002345)3.99701550
12Microretrognathia (HP:0000308)3.94711421
13Absence seizures (HP:0002121)3.91762200
14Aplasia/Hypoplasia of the sternum (HP:0006714)3.89555563
15Type II lissencephaly (HP:0007260)3.81119841
16Ankle clonus (HP:0011448)3.72262252
17Supranuclear gaze palsy (HP:0000605)3.71362886
18Generalized tonic-clonic seizures (HP:0002069)3.65376459
19Pancreatic cysts (HP:0001737)3.62415310
20Poor eye contact (HP:0000817)3.55981625
21Dialeptic seizures (HP:0011146)3.49668476
22Congenital stationary night blindness (HP:0007642)3.44045476
23Broad-based gait (HP:0002136)3.34839011
24Papilledema (HP:0001085)3.29982129
25Abnormal social behavior (HP:0012433)3.28694906
26Impaired social interactions (HP:0000735)3.28694906
27Gaze-evoked nystagmus (HP:0000640)3.27827253
28Lissencephaly (HP:0001339)3.24491713
29Depression (HP:0000716)3.22146501
30Impaired vibration sensation in the lower limbs (HP:0002166)3.16458467
31Urinary bladder sphincter dysfunction (HP:0002839)3.11801316
32True hermaphroditism (HP:0010459)3.08319627
33Gait imbalance (HP:0002141)3.05155049
34Truncal ataxia (HP:0002078)3.04269379
35Patellar aplasia (HP:0006443)3.03902101
36Pancreatic fibrosis (HP:0100732)3.03178678
37Anxiety (HP:0000739)3.01193665
38Protruding tongue (HP:0010808)2.99460938
39Nephronophthisis (HP:0000090)2.98830267
40Hyperventilation (HP:0002883)2.98559097
41Postural instability (HP:0002172)2.97838069
42Dysdiadochokinesis (HP:0002075)2.97555487
43Abnormality of the lower motor neuron (HP:0002366)2.95116955
44Dysmetria (HP:0001310)2.89874359
45Abnormality of midbrain morphology (HP:0002418)2.88105289
46Molar tooth sign on MRI (HP:0002419)2.88105289
47Long foot (HP:0001833)2.87388585
48Torticollis (HP:0000473)2.85907699
49Aplasia/Hypoplasia of the patella (HP:0006498)2.85699191
50Medial flaring of the eyebrow (HP:0010747)2.82245712
51Mutism (HP:0002300)2.78154936
52Genetic anticipation (HP:0003743)2.76419768
53Impaired smooth pursuit (HP:0007772)2.75013405
54Amblyopia (HP:0000646)2.74610852
55Congenital primary aphakia (HP:0007707)2.74301734
56Agitation (HP:0000713)2.74201494
57Abnormal eating behavior (HP:0100738)2.72214459
58Scanning speech (HP:0002168)2.67220530
59Urinary urgency (HP:0000012)2.66529571
60Abnormality of the renal cortex (HP:0011035)2.63480049
61Megalencephaly (HP:0001355)2.62823436
62Epileptiform EEG discharges (HP:0011182)2.62699253
63Focal dystonia (HP:0004373)2.61896861
64Abnormality of the renal medulla (HP:0100957)2.61591385
65Spastic gait (HP:0002064)2.61375968
66Intention tremor (HP:0002080)2.59485078
67EEG with generalized epileptiform discharges (HP:0011198)2.59319963
68Nephrogenic diabetes insipidus (HP:0009806)2.55600915
69Stereotypic behavior (HP:0000733)2.53775035
70Drooling (HP:0002307)2.53016636
71Excessive salivation (HP:0003781)2.53016636
72Hypsarrhythmia (HP:0002521)2.50712326
73Scrotal hypoplasia (HP:0000046)2.49338339
74Limb dystonia (HP:0002451)2.45745764
75Neurofibrillary tangles (HP:0002185)2.45379438
76Status epilepticus (HP:0002133)2.44291580
77Poor speech (HP:0002465)2.40824037
78Bradykinesia (HP:0002067)2.40307629
79Hemiplegia (HP:0002301)2.39707474
80Large for gestational age (HP:0001520)2.39463710
81Craniofacial dystonia (HP:0012179)2.37972194
82Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.35744512
83Dysmetric saccades (HP:0000641)2.35630566
84Abnormality of ocular smooth pursuit (HP:0000617)2.33160728
85Macroorchidism (HP:0000053)2.32000531
86Hemiparesis (HP:0001269)2.29579470
87Tubular atrophy (HP:0000092)2.29137958
88Widely spaced teeth (HP:0000687)2.28718379
89Abnormal respiratory epithelium morphology (HP:0012253)2.28064190
90Abnormal respiratory motile cilium morphology (HP:0005938)2.28064190
91Diastasis recti (HP:0001540)2.27854661
92Cerebral inclusion bodies (HP:0100314)2.25998544
93Impaired vibratory sensation (HP:0002495)2.25131823
94Abnormal ciliary motility (HP:0012262)2.22828891
95Poor coordination (HP:0002370)2.22114538
96Abnormality of binocular vision (HP:0011514)2.21833076
97Diplopia (HP:0000651)2.21833076
98Absent speech (HP:0001344)2.21715297
99Progressive inability to walk (HP:0002505)2.19337750
100Ventricular fibrillation (HP:0001663)2.18811380
101Pachygyria (HP:0001302)2.17185367
102Genital tract atresia (HP:0001827)2.15746806
103Pendular nystagmus (HP:0012043)2.15324224
104Retinal dysplasia (HP:0007973)2.15000495
105Pheochromocytoma (HP:0002666)2.14397143
106Annular pancreas (HP:0001734)2.14366047
107Clonus (HP:0002169)2.13189010
108Vaginal atresia (HP:0000148)2.13083291
109Blue irides (HP:0000635)2.12295358
110Concave nail (HP:0001598)2.11521907
111Chorioretinal atrophy (HP:0000533)2.10965104
112Cystic liver disease (HP:0006706)2.10925816
113Lower limb muscle weakness (HP:0007340)2.06808060
114Insidious onset (HP:0003587)2.06713783
115Termporal pattern (HP:0011008)2.06713783
116Central scotoma (HP:0000603)2.06142079
117Depressed nasal tip (HP:0000437)2.05638306
118Generalized myoclonic seizures (HP:0002123)2.05459193
119Attenuation of retinal blood vessels (HP:0007843)2.05250625
120Insomnia (HP:0100785)2.04452212
121Hypothermia (HP:0002045)2.04152689
122Chronic hepatic failure (HP:0100626)2.02097580
123Abnormality of the corticospinal tract (HP:0002492)2.01280962
124Optic nerve hypoplasia (HP:0000609)2.01261457
125Decreased circulating renin level (HP:0003351)2.00541637
126Gait ataxia (HP:0002066)1.96932610
127Pointed chin (HP:0000307)1.95774167
128Abnormal rod and cone electroretinograms (HP:0008323)1.95369572
129Severe muscular hypotonia (HP:0006829)1.94747087
130Inability to walk (HP:0002540)1.94040684
131Large eyes (HP:0001090)1.92865158
132Resting tremor (HP:0002322)1.91877157
133Hip dysplasia (HP:0001385)1.87029585
134Bundle branch block (HP:0011710)1.85486786
135Microtia (HP:0008551)1.84483896
136Spinal canal stenosis (HP:0003416)1.83909587
137Fetal akinesia sequence (HP:0001989)1.82325006
138Cerebellar dysplasia (HP:0007033)1.81785195
139Abnormal EKG (HP:0003115)1.81531359
140Polyphagia (HP:0002591)1.81376652
141Anencephaly (HP:0002323)1.81055646
142Abnormality of saccadic eye movements (HP:0000570)1.81041375
143Neuronal loss in central nervous system (HP:0002529)1.79732520
144Progressive microcephaly (HP:0000253)1.79643973
145Sclerocornea (HP:0000647)1.79599949
146Aplasia/Hypoplasia of the tongue (HP:0010295)1.79261748
147Abnormality of macular pigmentation (HP:0008002)1.79088813
148Furrowed tongue (HP:0000221)1.77837138
149Amyotrophic lateral sclerosis (HP:0007354)1.77701385
150Postural tremor (HP:0002174)1.76346461
151Bony spicule pigmentary retinopathy (HP:0007737)1.76278256
152Psychosis (HP:0000709)1.76259483
153Obstructive sleep apnea (HP:0002870)1.76212001
154Rigidity (HP:0002063)1.75978891
155Abnormality of the clitoris (HP:0000056)1.75663280
156Failure to thrive in infancy (HP:0001531)1.75282121
157Dyskinesia (HP:0100660)1.74671727
158Abnormality of the vitreous humor (HP:0004327)1.74343227
159Abnormal biliary tract physiology (HP:0012439)1.73456805
160Bile duct proliferation (HP:0001408)1.73456805
161Aplasia involving bones of the upper limbs (HP:0009823)1.73406133
162Aplasia of the phalanges of the hand (HP:0009802)1.73406133
163Aplasia involving bones of the extremities (HP:0009825)1.73406133
164Female pseudohermaphroditism (HP:0010458)1.73206307
165Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72571106
166Absent/shortened dynein arms (HP:0200106)1.72275534
167Dynein arm defect of respiratory motile cilia (HP:0012255)1.72275534
168Incomplete penetrance (HP:0003829)1.71971723
169Slender long bone (HP:0003100)1.71686162
170Neuroendocrine neoplasm (HP:0100634)1.71281380
171Abolished electroretinogram (ERG) (HP:0000550)1.69988517
172Hypoplasia of the brainstem (HP:0002365)1.68002403
173Aplasia/Hypoplasia of the brainstem (HP:0007362)1.68002403
174Oligodactyly (hands) (HP:0001180)1.65886429
175Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65795410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B5.29502665
2BMPR1B4.23158649
3NTRK34.20247035
4MAP3K94.09310561
5EPHA44.03241036
6FRK3.60579790
7MARK13.30092391
8MAP3K42.89923775
9DAPK22.88543969
10MINK12.54664584
11MAP2K72.48471443
12PRKD32.26259048
13PAK62.22499005
14NTRK22.18463825
15CAMKK12.11030320
16KSR21.96613504
17NTRK11.92562820
18ADRBK21.90847397
19MAP2K41.90512694
20NME11.83879819
21TGFBR11.78114869
22ZAK1.77675086
23MAP3K21.75767869
24CAMK1D1.75470390
25CDK51.63054598
26MAP3K121.56786207
27KSR11.56244559
28DAPK11.49339549
29STK391.48003335
30CASK1.43367302
31CAMKK21.43214626
32GRK11.40744387
33TAOK11.37321414
34SIK21.36988158
35MAPK131.36134908
36CDK191.35717079
37STK381.35312629
38TYRO31.32255331
39MAP4K21.31340349
40RIPK41.28425857
41MAP2K61.27018178
42TNIK1.25526171
43UHMK11.25224118
44PRPF4B1.18472524
45MKNK21.17236643
46MAPKAPK31.14923233
47GRK51.13160752
48FES1.13048433
49PRKCG1.11860065
50SGK2231.08366328
51SGK4941.08366328
52MAP3K131.06639206
53PRKCH1.06579075
54ARAF1.05386841
55STK38L1.04049839
56CAMK11.03085078
57TLK10.99901149
58STK110.98011944
59RET0.97878925
60LMTK20.94771291
61PNCK0.94392801
62PHKG20.92553775
63PHKG10.92553775
64SGK20.92210750
65SGK30.89507941
66PINK10.88595843
67DYRK20.88444123
68MARK20.85499735
69CAMK1G0.83274062
70PLK20.80489100
71CAMK2A0.79749231
72CDK180.79343220
73PIK3CA0.78381693
74PAK30.78135705
75RIPK10.77567868
76CDK150.76427804
77CSNK1G20.74695438
78MAP3K10.73785242
79SIK30.72992972
80ALK0.72048307
81CDK140.71818796
82OXSR10.71520412
83DYRK1A0.70560754
84TNK20.69339673
85SGK10.68482461
86ADRBK10.67366358
87PDK10.67013867
88CSNK1G30.66454040
89PDPK10.65862572
90CDK11A0.65779028
91INSRR0.65480713
92FGFR20.65012259
93CDC42BPA0.64834599
94PRKCI0.64337849
95PRKCZ0.62730964
96NEK60.61501932
97CAMK2B0.60493820
98WNK10.57931842
99RAF10.57659377
100TAOK30.57444882
101ERBB30.56977694
102CSNK1A10.56500742
103CSNK1G10.56038571
104CAMK40.55473849
105LATS20.55371089
106BMPR20.54397813
107FER0.51606837
108RPS6KA30.50804292
109PRKAA10.50744479
110CSNK1A1L0.49654014
111FYN0.49042344
112MAP3K70.48521068
113RPS6KA20.47557702
114HIPK20.45824533
115PRKCE0.45151888
116TRIM280.43895393
117CHUK0.43839455
118RPS6KB20.43374665
119TSSK60.42610294
120MAPK100.42504133
121CAMK2G0.39741751
122EPHA30.39334259
123PRKAA20.37861644
124TRIB30.37341874
125CSNK1D0.36263421
126PTK2B0.36005944
127RPS6KA60.35524748
128MELK0.35467394
129WNK30.35307819
130MAPK120.34861567
131MAPKAPK50.34776048
132MAP2K10.34493733
133CCNB10.34438505
134CAMK2D0.32343061
135PRKCB0.32171590
136SCYL20.31988302
137AKT30.31753621
138MUSK0.29355374
139IRAK10.28656382
140PKN20.28046637
141WNK40.27031932
142RPS6KB10.26593832
143PRKACA0.24857602
144MST40.24256982

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.32044776
2Nicotine addiction_Homo sapiens_hsa050333.13175266
3Olfactory transduction_Homo sapiens_hsa047402.69854339
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.54826871
5GABAergic synapse_Homo sapiens_hsa047272.54125203
6Circadian entrainment_Homo sapiens_hsa047132.53260847
7Glutamatergic synapse_Homo sapiens_hsa047242.40593448
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.39629814
9Long-term potentiation_Homo sapiens_hsa047202.37333926
10Morphine addiction_Homo sapiens_hsa050322.35555742
11Amphetamine addiction_Homo sapiens_hsa050312.26860620
12Insulin secretion_Homo sapiens_hsa049112.24851248
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16321620
14ABC transporters_Homo sapiens_hsa020102.15712101
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14510069
16Dopaminergic synapse_Homo sapiens_hsa047282.05480480
17Linoleic acid metabolism_Homo sapiens_hsa005912.02467562
18Salivary secretion_Homo sapiens_hsa049702.01824914
19Cholinergic synapse_Homo sapiens_hsa047251.93806756
20Selenocompound metabolism_Homo sapiens_hsa004501.89973249
21Ether lipid metabolism_Homo sapiens_hsa005651.88141716
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86771442
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.83659870
24Gastric acid secretion_Homo sapiens_hsa049711.83248868
25Cocaine addiction_Homo sapiens_hsa050301.73562102
26Nitrogen metabolism_Homo sapiens_hsa009101.61444346
27Taste transduction_Homo sapiens_hsa047421.59355074
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58082501
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54766084
30Renin secretion_Homo sapiens_hsa049241.52500493
31Oxytocin signaling pathway_Homo sapiens_hsa049211.51183561
32Fatty acid biosynthesis_Homo sapiens_hsa000611.50516296
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48319035
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47950202
35Long-term depression_Homo sapiens_hsa047301.45406086
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45262573
37Type II diabetes mellitus_Homo sapiens_hsa049301.45017796
38Serotonergic synapse_Homo sapiens_hsa047261.44039292
39Calcium signaling pathway_Homo sapiens_hsa040201.32531814
40GnRH signaling pathway_Homo sapiens_hsa049121.32232653
41Phototransduction_Homo sapiens_hsa047441.29531717
42Tryptophan metabolism_Homo sapiens_hsa003801.28680973
43beta-Alanine metabolism_Homo sapiens_hsa004101.26197548
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24970265
45cAMP signaling pathway_Homo sapiens_hsa040241.24424210
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23276490
47Gap junction_Homo sapiens_hsa045401.21901044
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21801022
49Collecting duct acid secretion_Homo sapiens_hsa049661.18018450
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13686394
51Estrogen signaling pathway_Homo sapiens_hsa049151.11652979
52Oxidative phosphorylation_Homo sapiens_hsa001901.09431689
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.07760042
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03964564
55Glioma_Homo sapiens_hsa052141.02447606
56Pancreatic secretion_Homo sapiens_hsa049721.02273452
57ErbB signaling pathway_Homo sapiens_hsa040121.01649257
58Axon guidance_Homo sapiens_hsa043600.97722511
59Vibrio cholerae infection_Homo sapiens_hsa051100.97245206
60cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97010062
61Mineral absorption_Homo sapiens_hsa049780.93001127
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90402509
63Melanogenesis_Homo sapiens_hsa049160.88481447
64Dorso-ventral axis formation_Homo sapiens_hsa043200.85360950
65Thyroid hormone synthesis_Homo sapiens_hsa049180.85314357
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84392702
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.84304413
68Sulfur metabolism_Homo sapiens_hsa009200.81662129
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.80648632
70Vitamin B6 metabolism_Homo sapiens_hsa007500.79775243
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79675910
72Propanoate metabolism_Homo sapiens_hsa006400.79145622
73Basal transcription factors_Homo sapiens_hsa030220.76462481
74Circadian rhythm_Homo sapiens_hsa047100.74836200
75Protein export_Homo sapiens_hsa030600.74636835
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74532783
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72025839
78Chemical carcinogenesis_Homo sapiens_hsa052040.71439985
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70940997
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.70679156
81Histidine metabolism_Homo sapiens_hsa003400.69942633
82Bile secretion_Homo sapiens_hsa049760.68862843
83Choline metabolism in cancer_Homo sapiens_hsa052310.68516615
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66790246
85Steroid biosynthesis_Homo sapiens_hsa001000.65780784
86MAPK signaling pathway_Homo sapiens_hsa040100.63966076
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62510678
88Inositol phosphate metabolism_Homo sapiens_hsa005620.62138849
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61537476
90Peroxisome_Homo sapiens_hsa041460.60791551
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60343237
92Type I diabetes mellitus_Homo sapiens_hsa049400.60295291
93Glucagon signaling pathway_Homo sapiens_hsa049220.58484440
94Endometrial cancer_Homo sapiens_hsa052130.58298651
95Alzheimers disease_Homo sapiens_hsa050100.58240644
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57964069
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57237279
98VEGF signaling pathway_Homo sapiens_hsa043700.57041628
99mTOR signaling pathway_Homo sapiens_hsa041500.56536461
100Caffeine metabolism_Homo sapiens_hsa002320.55057191
101Steroid hormone biosynthesis_Homo sapiens_hsa001400.53583323
102Oocyte meiosis_Homo sapiens_hsa041140.53173278
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52792448
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51152147
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50626494
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.50460730
107Ras signaling pathway_Homo sapiens_hsa040140.50348860
108Arginine and proline metabolism_Homo sapiens_hsa003300.49853469
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.49484383
110Endocytosis_Homo sapiens_hsa041440.49375646
111Non-small cell lung cancer_Homo sapiens_hsa052230.48186393
112Arginine biosynthesis_Homo sapiens_hsa002200.47049997
113Rap1 signaling pathway_Homo sapiens_hsa040150.47027654
114Dilated cardiomyopathy_Homo sapiens_hsa054140.46882833
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46518091
116Glycerolipid metabolism_Homo sapiens_hsa005610.46437354
117Prolactin signaling pathway_Homo sapiens_hsa049170.46298508
118Arachidonic acid metabolism_Homo sapiens_hsa005900.45984113
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45922173
120Lysosome_Homo sapiens_hsa041420.45507274
121Prion diseases_Homo sapiens_hsa050200.45467530
122Renal cell carcinoma_Homo sapiens_hsa052110.45440734
123Insulin signaling pathway_Homo sapiens_hsa049100.45423760
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44841027
125Sphingolipid metabolism_Homo sapiens_hsa006000.44607313
126Tyrosine metabolism_Homo sapiens_hsa003500.43970778
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.43802803
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43733065
129Vitamin digestion and absorption_Homo sapiens_hsa049770.43541146
130Alcoholism_Homo sapiens_hsa050340.43371771
131Cardiac muscle contraction_Homo sapiens_hsa042600.42930712
132Chemokine signaling pathway_Homo sapiens_hsa040620.38340043
133Parkinsons disease_Homo sapiens_hsa050120.38318246
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36669549
135RNA degradation_Homo sapiens_hsa030180.35858793
136Metabolic pathways_Homo sapiens_hsa011000.35484895
137Ovarian steroidogenesis_Homo sapiens_hsa049130.35038860
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34106184
139Wnt signaling pathway_Homo sapiens_hsa043100.33302563
140Huntingtons disease_Homo sapiens_hsa050160.32626260
141Fanconi anemia pathway_Homo sapiens_hsa034600.32251427
142Butanoate metabolism_Homo sapiens_hsa006500.31875612
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.29283624
144Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28946658
145Colorectal cancer_Homo sapiens_hsa052100.28274269

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