TBC1D32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a TBC-domain containing protein. Studies of a similar protein in mouse and zebrafish suggest that the encoded protein is involved in sonic hedgehog signaling, and that it interacts with and stabilizes cell cycle-related kinase. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.53903178
2neural tube formation (GO:0001841)4.54583623
3presynaptic membrane organization (GO:0097090)4.50866698
4behavioral response to nicotine (GO:0035095)4.41893515
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.39012745
6prostate gland growth (GO:0060736)4.14328151
7negative regulation of dendrite morphogenesis (GO:0050774)4.07480896
8indole-containing compound catabolic process (GO:0042436)4.01720448
9indolalkylamine catabolic process (GO:0046218)4.01720448
10tryptophan catabolic process (GO:0006569)4.01720448
11detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.80154301
12dendritic spine morphogenesis (GO:0060997)3.79581048
13response to pheromone (GO:0019236)3.76929181
14indolalkylamine metabolic process (GO:0006586)3.75450260
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73536556
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.73488960
17kynurenine metabolic process (GO:0070189)3.68934474
18sulfate transmembrane transport (GO:1902358)3.66255735
19neuron cell-cell adhesion (GO:0007158)3.64971292
20positive regulation of neurological system process (GO:0031646)3.64069671
21reflex (GO:0060004)3.61172880
22L-fucose catabolic process (GO:0042355)3.49487788
23fucose catabolic process (GO:0019317)3.49487788
24L-fucose metabolic process (GO:0042354)3.49487788
25establishment of protein localization to Golgi (GO:0072600)3.47509471
26detection of light stimulus involved in sensory perception (GO:0050962)3.47220057
27detection of light stimulus involved in visual perception (GO:0050908)3.47220057
28cilium movement (GO:0003341)3.46912154
29positive regulation of dendritic spine morphogenesis (GO:0061003)3.45085086
30phosphorylated carbohydrate dephosphorylation (GO:0046838)3.42231333
31inositol phosphate dephosphorylation (GO:0046855)3.42231333
32detection of calcium ion (GO:0005513)3.37417590
33tryptophan metabolic process (GO:0006568)3.35543068
34negative regulation of neurotransmitter secretion (GO:0046929)3.34883865
35ER overload response (GO:0006983)3.33535664
36mating behavior (GO:0007617)3.33230697
37cerebellar Purkinje cell differentiation (GO:0021702)3.32082110
38protein K11-linked deubiquitination (GO:0035871)3.28558928
39negative regulation of dendrite development (GO:2000171)3.21194011
40regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20516546
41positive regulation of membrane potential (GO:0045838)3.19587414
42neuron-neuron synaptic transmission (GO:0007270)3.17630503
43gamma-aminobutyric acid signaling pathway (GO:0007214)3.17137907
44behavioral response to ethanol (GO:0048149)3.16329230
45axoneme assembly (GO:0035082)3.14690981
46retinal cone cell development (GO:0046549)3.11546832
47water-soluble vitamin biosynthetic process (GO:0042364)3.11093669
48glutamate receptor signaling pathway (GO:0007215)3.10376489
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09555115
50neuronal action potential (GO:0019228)3.08999206
51tachykinin receptor signaling pathway (GO:0007217)3.06654489
52ionotropic glutamate receptor signaling pathway (GO:0035235)3.06283318
53epithelial cilium movement (GO:0003351)3.02759202
54nonmotile primary cilium assembly (GO:0035058)3.02581229
55interkinetic nuclear migration (GO:0022027)3.02185481
56cilium or flagellum-dependent cell motility (GO:0001539)3.01526378
57negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.99959157
58regulation of dendritic spine morphogenesis (GO:0061001)2.99721046
59cilium organization (GO:0044782)2.98511042
60negative regulation of mast cell activation (GO:0033004)2.96496205
61cilium assembly (GO:0042384)2.95949469
62long-term synaptic potentiation (GO:0060291)2.95282582
63retinal rod cell development (GO:0046548)2.95088426
64* cilium morphogenesis (GO:0060271)2.93529666
65regulation of excitatory postsynaptic membrane potential (GO:0060079)2.93394743
66inositol phosphate catabolic process (GO:0071545)2.91380283
67long term synaptic depression (GO:0060292)2.89372025
68protein polyglutamylation (GO:0018095)2.88933575
69protein localization to synapse (GO:0035418)2.87880134
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.87614287
71transmission of nerve impulse (GO:0019226)2.87397540
72innervation (GO:0060384)2.86369919
73ventricular system development (GO:0021591)2.85604278
74regulation of rhodopsin mediated signaling pathway (GO:0022400)2.82753789
75kidney morphogenesis (GO:0060993)2.81840341
76inner ear receptor cell development (GO:0060119)2.81740623
77striatum development (GO:0021756)2.81729631
78indole-containing compound metabolic process (GO:0042430)2.80892040
79regulation of postsynaptic membrane potential (GO:0060078)2.80883192
80positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.80622087
81behavioral response to cocaine (GO:0048148)2.79826583
82phosphatidylinositol dephosphorylation (GO:0046856)2.78822718
83synaptic vesicle exocytosis (GO:0016079)2.76816443
84regulation of short-term neuronal synaptic plasticity (GO:0048172)2.76647958
85prepulse inhibition (GO:0060134)2.76617005
86axonal fasciculation (GO:0007413)2.76372240
87sulfate transport (GO:0008272)2.75615800
88rhodopsin mediated signaling pathway (GO:0016056)2.75271915
89centriole replication (GO:0007099)2.74956797
90synaptic transmission, glutamatergic (GO:0035249)2.74937866
91glutamate secretion (GO:0014047)2.74539209
92cellular ketone body metabolic process (GO:0046950)2.73922210
93axonemal dynein complex assembly (GO:0070286)2.72392231
94pyrimidine nucleobase catabolic process (GO:0006208)2.71942838
95eye photoreceptor cell differentiation (GO:0001754)2.71643043
96photoreceptor cell differentiation (GO:0046530)2.71643043
97* protein localization to cilium (GO:0061512)2.71160101
98DNA double-strand break processing (GO:0000729)2.71146886
99neuron recognition (GO:0008038)2.70908366
100negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.70644197
101negative regulation of neurotransmitter transport (GO:0051589)2.69627355
102positive regulation of meiosis (GO:0045836)2.69280199
103protein targeting to Golgi (GO:0000042)2.68341990
104regulation of action potential (GO:0098900)2.67900342
105membrane hyperpolarization (GO:0060081)2.67383095
106gamma-aminobutyric acid transport (GO:0015812)2.67355100
107response to histamine (GO:0034776)2.66530059
108cornea development in camera-type eye (GO:0061303)2.66162135
109photoreceptor cell maintenance (GO:0045494)2.66064259
110tyrosine metabolic process (GO:0006570)2.63600775
111inner ear receptor stereocilium organization (GO:0060122)2.63579077
112phospholipid dephosphorylation (GO:0046839)2.63521307
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.63445082
114negative regulation of translation, ncRNA-mediated (GO:0040033)2.63445082
115regulation of translation, ncRNA-mediated (GO:0045974)2.63445082
116cellular biogenic amine catabolic process (GO:0042402)2.63362089
117amine catabolic process (GO:0009310)2.63362089
118positive regulation of oligodendrocyte differentiation (GO:0048714)2.63206488
119negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62441175
120histone H3-K4 trimethylation (GO:0080182)2.62127020
121sulfation (GO:0051923)2.61529625
122membrane assembly (GO:0071709)2.61382295
123positive regulation of gastrulation (GO:2000543)2.61331747
124regulation of telomere maintenance (GO:0032204)2.61145297
125recombinational repair (GO:0000725)2.60877091
126double-strand break repair via homologous recombination (GO:0000724)2.60859907
127dentate gyrus development (GO:0021542)2.60735289
128central nervous system neuron axonogenesis (GO:0021955)2.60480226
129preassembly of GPI anchor in ER membrane (GO:0016254)2.59307956
130startle response (GO:0001964)2.59018158
131oxidative demethylation (GO:0070989)2.58871282
132embryonic epithelial tube formation (GO:0001838)2.58780553
133detection of mechanical stimulus involved in sensory perception (GO:0050974)2.58034248
134synapse assembly (GO:0007416)2.57953557
135vocalization behavior (GO:0071625)2.57611842
136regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.56718011
137righting reflex (GO:0060013)2.55959445
138regulation of establishment of cell polarity (GO:2000114)2.54457481
139intraciliary transport (GO:0042073)2.54252676
140primary amino compound metabolic process (GO:1901160)2.53980044
141negative regulation of telomere maintenance (GO:0032205)2.53797580
142regulation of cilium movement (GO:0003352)2.53561248
143piRNA metabolic process (GO:0034587)2.52118498
144maternal behavior (GO:0042711)2.50645034
145eye photoreceptor cell development (GO:0042462)2.49996387
146reciprocal meiotic recombination (GO:0007131)2.49910941
147reciprocal DNA recombination (GO:0035825)2.49910941
148signal peptide processing (GO:0006465)2.48874349
149regulation of hexokinase activity (GO:1903299)2.48152411
150regulation of glucokinase activity (GO:0033131)2.48152411
151benzene-containing compound metabolic process (GO:0042537)2.47893596
152nucleobase catabolic process (GO:0046113)2.47741091
153dendrite morphogenesis (GO:0048813)2.47455678
154cellular response to sterol (GO:0036315)2.47340953
155regulation of pigment cell differentiation (GO:0050932)2.46885739
156L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46310316
157thyroid hormone metabolic process (GO:0042403)2.45723700
158protein localization to Golgi apparatus (GO:0034067)2.45307513
159positive regulation of developmental pigmentation (GO:0048087)2.45244884
160serotonin metabolic process (GO:0042428)2.45230783
161neuronal ion channel clustering (GO:0045161)2.44767904
162limb bud formation (GO:0060174)2.44331883
163retina layer formation (GO:0010842)2.44288024
164replication fork processing (GO:0031297)2.44251542
165neuronal action potential propagation (GO:0019227)2.44102037
166glycosphingolipid biosynthetic process (GO:0006688)2.43935015
167regulation of hippo signaling (GO:0035330)2.43669386
168ketone body metabolic process (GO:1902224)2.43650008
169auditory behavior (GO:0031223)2.43339114
170retrograde transport, vesicle recycling within Golgi (GO:0000301)2.42513928
171positive regulation of meiotic cell cycle (GO:0051446)2.42507569
172retinal ganglion cell axon guidance (GO:0031290)2.42482253
173postsynaptic membrane organization (GO:0001941)2.41683322
174regulation of synaptic vesicle exocytosis (GO:2000300)2.41125312
175multi-organism reproductive behavior (GO:0044705)2.40913877
176cellular component assembly involved in morphogenesis (GO:0010927)2.40817835
177membrane depolarization (GO:0051899)2.39775129
178negative regulation of synaptic transmission (GO:0050805)2.38994161
179photoreceptor cell development (GO:0042461)2.38642439
180sensory perception of smell (GO:0007608)2.36438198
181glomerular filtration (GO:0003094)2.36415461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.22899449
2EZH2_22144423_ChIP-Seq_EOC_Human2.97155331
3ZNF274_21170338_ChIP-Seq_K562_Hela2.90361813
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.66052874
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61279238
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40293295
7TAF15_26573619_Chip-Seq_HEK293_Human2.37653838
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36870117
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30589273
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29930241
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29212913
12SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15917299
13SMAD4_21799915_ChIP-Seq_A2780_Human2.04053038
14P300_19829295_ChIP-Seq_ESCs_Human2.03495968
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99661252
16SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99655231
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.95500129
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95285219
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92292172
20AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91246907
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88128276
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82739988
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78192916
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76571236
25AR_21572438_ChIP-Seq_LNCaP_Human1.76023356
26FUS_26573619_Chip-Seq_HEK293_Human1.72157462
27CBP_20019798_ChIP-Seq_JUKART_Human1.71188831
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71188831
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71093651
30STAT3_23295773_ChIP-Seq_U87_Human1.69428300
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68419113
32ER_23166858_ChIP-Seq_MCF-7_Human1.67751170
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65735568
34IGF1R_20145208_ChIP-Seq_DFB_Human1.64916495
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.64320018
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64194949
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.63248703
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.62829043
39DROSHA_22980978_ChIP-Seq_HELA_Human1.62221253
40OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60283828
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59591399
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59566089
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59566089
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.58752215
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58550380
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57740858
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.56477027
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53600920
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52920465
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52784905
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52652676
52TCF4_23295773_ChIP-Seq_U87_Human1.52625347
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51708912
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50869370
55IRF1_19129219_ChIP-ChIP_H3396_Human1.50482948
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50456753
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49423372
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49423372
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48868181
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48765336
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48735994
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47260290
63VDR_22108803_ChIP-Seq_LS180_Human1.46266379
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.44905992
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43536107
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.42904549
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.41569927
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41322801
69BCAT_22108803_ChIP-Seq_LS180_Human1.40601274
70P53_22387025_ChIP-Seq_ESCs_Mouse1.39009505
71REST_21632747_ChIP-Seq_MESCs_Mouse1.37998652
72TCF4_22108803_ChIP-Seq_LS180_Human1.37957317
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.35640424
74TP53_16413492_ChIP-PET_HCT116_Human1.35156372
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34669193
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34659261
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.34397745
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.33690538
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33234231
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.32902614
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.32574207
82RUNX2_22187159_ChIP-Seq_PCA_Human1.32352504
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.31630004
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31358496
85AHR_22903824_ChIP-Seq_MCF-7_Human1.30866493
86RNF2_27304074_Chip-Seq_NSC_Mouse1.29829006
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29397582
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26571078
89AR_25329375_ChIP-Seq_VCAP_Human1.26160561
90P300_18555785_Chip-Seq_ESCs_Mouse1.25864569
91TP53_22573176_ChIP-Seq_HFKS_Human1.25761331
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.25129698
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24159217
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23498666
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20475198
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.19081687
97SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18632713
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.18574344
99TP53_18474530_ChIP-ChIP_U2OS_Human1.18566484
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18310249
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17993580
102EWS_26573619_Chip-Seq_HEK293_Human1.17945182
103SMAD4_21741376_ChIP-Seq_EPCs_Human1.16899967
104SOX2_19829295_ChIP-Seq_ESCs_Human1.16173703
105NANOG_19829295_ChIP-Seq_ESCs_Human1.16173703
106SOX2_18555785_Chip-Seq_ESCs_Mouse1.16094732
107MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16014224
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15460761
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.14923383
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14509940
111SALL1_21062744_ChIP-ChIP_HESCs_Human1.14206987
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13054341
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.12470265
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12440050
115STAT3_18555785_Chip-Seq_ESCs_Mouse1.11633024
116CDX2_22108803_ChIP-Seq_LS180_Human1.09832042
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09754233
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09657560
119AR_19668381_ChIP-Seq_PC3_Human1.09352097
120NOTCH1_21737748_ChIP-Seq_TLL_Human1.09030725
121MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09027470
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08530404
123TAL1_26923725_Chip-Seq_HPCs_Mouse1.08381978
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08142833
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07977510
126YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07486220
127RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07444819
128FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06297245
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05004616
130KDM2B_26808549_Chip-Seq_REH_Human1.04084242
131FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02036531
132OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01854382
133FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00903574
134FOXA1_25329375_ChIP-Seq_VCAP_Human1.00903574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction3.41328910
2MP0005423_abnormal_somatic_nervous3.32095400
3MP0003880_abnormal_central_pattern3.27229936
4MP0005171_absent_coat_pigmentation3.26241328
5MP0005551_abnormal_eye_electrophysiolog2.98813463
6MP0003195_calcinosis2.97805213
7MP0001188_hyperpigmentation2.73055944
8MP0003879_abnormal_hair_cell2.55335829
9MP0003635_abnormal_synaptic_transmissio2.44432413
10MP0004859_abnormal_synaptic_plasticity2.44239021
11MP0001486_abnormal_startle_reflex2.38590275
12MP0002837_dystrophic_cardiac_calcinosis2.32525712
13MP0009745_abnormal_behavioral_response2.31229859
14MP0006292_abnormal_olfactory_placode2.23375175
15MP0010386_abnormal_urinary_bladder2.22992357
16MP0010234_abnormal_vibrissa_follicle2.10870692
17MP0009780_abnormal_chondrocyte_physiolo2.07451905
18MP0009697_abnormal_copulation2.04459272
19MP0002272_abnormal_nervous_system2.00984382
20MP0002063_abnormal_learning/memory/cond1.99591984
21MP0002876_abnormal_thyroid_physiology1.92261158
22MP0000778_abnormal_nervous_system1.91979193
23MP0006072_abnormal_retinal_apoptosis1.91358978
24MP0002572_abnormal_emotion/affect_behav1.90275816
25MP0002064_seizures1.88262003
26MP0009046_muscle_twitch1.85290137
27MP0005367_renal/urinary_system_phenotyp1.82431024
28MP0000516_abnormal_urinary_system1.82431024
29MP0003787_abnormal_imprinting1.81725909
30MP0005253_abnormal_eye_physiology1.78899971
31MP0004043_abnormal_pH_regulation1.76439992
32MP0004270_analgesia1.74494130
33MP0005623_abnormal_meninges_morphology1.71173779
34MP0001661_extended_life_span1.69048014
35MP0002928_abnormal_bile_duct1.64450478
36MP0004133_heterotaxia1.64210762
37MP0005499_abnormal_olfactory_system1.55947042
38MP0005394_taste/olfaction_phenotype1.55947042
39MP0000427_abnormal_hair_cycle1.54574657
40MP0005409_darkened_coat_color1.54067272
41MP0008789_abnormal_olfactory_epithelium1.53186174
42MP0003121_genomic_imprinting1.51547887
43MP0001348_abnormal_lacrimal_gland1.44826498
44MP0003646_muscle_fatigue1.43550126
45MP0000383_abnormal_hair_follicle1.43252158
46MP0002090_abnormal_vision1.42625936
47MP0000569_abnormal_digit_pigmentation1.42616386
48MP0002938_white_spotting1.41042978
49MP0001346_abnormal_lacrimal_gland1.40530621
50MP0008872_abnormal_physiological_respon1.39650246
51MP0005379_endocrine/exocrine_gland_phen1.36623504
52MP0002229_neurodegeneration1.36334667
53MP0003136_yellow_coat_color1.33005609
54MP0005195_abnormal_posterior_eye1.32797793
55MP0002234_abnormal_pharynx_morphology1.32083979
56MP0005386_behavior/neurological_phenoty1.30052967
57MP0004924_abnormal_behavior1.30052967
58MP0002638_abnormal_pupillary_reflex1.29339025
59MP0004233_abnormal_muscle_weight1.28199265
60MP0002653_abnormal_ependyma_morphology1.27629609
61MP0002067_abnormal_sensory_capabilities1.27607612
62MP0002882_abnormal_neuron_morphology1.26806703
63MP0002734_abnormal_mechanical_nocicepti1.25998432
64MP0002822_catalepsy1.25821209
65MP0001968_abnormal_touch/_nociception1.24652343
66MP0001905_abnormal_dopamine_level1.23989204
67MP0002752_abnormal_somatic_nervous1.23411668
68MP0001986_abnormal_taste_sensitivity1.22773036
69MP0001440_abnormal_grooming_behavior1.19373228
70MP0002184_abnormal_innervation1.19217649
71MP0001502_abnormal_circadian_rhythm1.18288904
72MP0002163_abnormal_gland_morphology1.17785115
73MP0004885_abnormal_endolymph1.16650476
74MP0001501_abnormal_sleep_pattern1.16278071
75MP0002102_abnormal_ear_morphology1.16246095
76MP0006276_abnormal_autonomic_nervous1.14308529
77MP0002557_abnormal_social/conspecific_i1.13882056
78MP0003868_abnormal_feces_composition1.13791978
79MP0001485_abnormal_pinna_reflex1.13394292
80MP0001970_abnormal_pain_threshold1.12721646
81MP0005646_abnormal_pituitary_gland1.10891839
82MP0004215_abnormal_myocardial_fiber1.10646256
83MP0003119_abnormal_digestive_system1.08544082
84MP0002735_abnormal_chemical_nociception1.07994475
85MP0003011_delayed_dark_adaptation1.07527068
86MP0010030_abnormal_orbit_morphology1.06566522
87MP0000566_synostosis1.06544751
88MP0001963_abnormal_hearing_physiology1.06100685
89MP0004142_abnormal_muscle_tone1.05401700
90MP0001529_abnormal_vocalization1.04896456
91MP0008875_abnormal_xenobiotic_pharmacok1.04443333
92MP0000647_abnormal_sebaceous_gland1.03437312
93MP0000372_irregular_coat_pigmentation1.02294480
94MP0008995_early_reproductive_senescence1.00625176
95MP0005187_abnormal_penis_morphology0.99755351
96MP0003634_abnormal_glial_cell0.99752595
97MP0002160_abnormal_reproductive_system0.99261788
98MP0000631_abnormal_neuroendocrine_gland0.98847058
99MP0002909_abnormal_adrenal_gland0.98629687
100MP0000026_abnormal_inner_ear0.95382798
101MP0004145_abnormal_muscle_electrophysio0.94058107
102MP0005389_reproductive_system_phenotype0.93844046
103MP0004742_abnormal_vestibular_system0.93831687
104MP0003252_abnormal_bile_duct0.93345590
105MP0004147_increased_porphyrin_level0.93163424
106MP0001177_atelectasis0.91859188
107MP0003690_abnormal_glial_cell0.91663781
108MP0003122_maternal_imprinting0.90379138
109MP0003718_maternal_effect0.86610112
110MP0001324_abnormal_eye_pigmentation0.86386606
111MP0002295_abnormal_pulmonary_circulatio0.86012968
112MP0000955_abnormal_spinal_cord0.85509103
113MP0003283_abnormal_digestive_organ0.85342003
114MP0002138_abnormal_hepatobiliary_system0.85261790
115MP0000538_abnormal_urinary_bladder0.85239043
116MP0000920_abnormal_myelination0.85201935
117MP0002332_abnormal_exercise_endurance0.83401738
118MP0010678_abnormal_skin_adnexa0.83020725
119MP0001293_anophthalmia0.82887167
120MP0002233_abnormal_nose_morphology0.82368718
121MP0003137_abnormal_impulse_conducting0.82002584
122MP0003045_fibrosis0.81831281
123MP0003698_abnormal_male_reproductive0.80600078
124MP0008877_abnormal_DNA_methylation0.80529416
125MP0005174_abnormal_tail_pigmentation0.79655785
126MP0005645_abnormal_hypothalamus_physiol0.78563702
127MP0002736_abnormal_nociception_after0.77461933
128MP0002152_abnormal_brain_morphology0.77235033
129MP0008057_abnormal_DNA_replication0.77054008
130MP0002733_abnormal_thermal_nociception0.76804024
131MP0002066_abnormal_motor_capabilities/c0.75851452
132MP0005248_abnormal_Harderian_gland0.75772234
133MP0003890_abnormal_embryonic-extraembry0.73409321
134MP0003937_abnormal_limbs/digits/tail_de0.70681096
135MP0002751_abnormal_autonomic_nervous0.70650423

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)4.69873831
2Pancreatic fibrosis (HP:0100732)4.16109626
3Central scotoma (HP:0000603)4.11206324
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.07642758
5Absent/shortened dynein arms (HP:0200106)4.07642758
6Abnormal respiratory motile cilium physiology (HP:0012261)3.92397027
7Febrile seizures (HP:0002373)3.86866721
8Progressive cerebellar ataxia (HP:0002073)3.78984536
9Congenital stationary night blindness (HP:0007642)3.74343558
10Atonic seizures (HP:0010819)3.63154379
11Abnormal respiratory motile cilium morphology (HP:0005938)3.59347961
12Abnormal respiratory epithelium morphology (HP:0012253)3.59347961
13Dyschromatopsia (HP:0007641)3.46603871
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.45215244
15Epileptic encephalopathy (HP:0200134)3.35298434
16Abnormality of macular pigmentation (HP:0008002)3.28273348
17Nephrogenic diabetes insipidus (HP:0009806)3.15378647
18Pancreatic cysts (HP:0001737)3.13610088
19Conjugated hyperbilirubinemia (HP:0002908)3.07193557
20Gait imbalance (HP:0002141)3.00427769
21Genetic anticipation (HP:0003743)3.00027833
22Aplasia/Hypoplasia of the tibia (HP:0005772)2.96855272
23Neoplasm of the adrenal cortex (HP:0100641)2.94720131
24Hyperthyroidism (HP:0000836)2.94027621
25Congenital primary aphakia (HP:0007707)2.91293869
26Medial flaring of the eyebrow (HP:0010747)2.90990658
27Attenuation of retinal blood vessels (HP:0007843)2.84683911
28Abnormality of midbrain morphology (HP:0002418)2.82313647
29Molar tooth sign on MRI (HP:0002419)2.82313647
30Abnormality of the right ventricle (HP:0001707)2.79680221
31Abnormality of the nasal septum (HP:0000419)2.77358007
32Focal motor seizures (HP:0011153)2.76746414
33Nephronophthisis (HP:0000090)2.74984834
34Type II lissencephaly (HP:0007260)2.69273045
35Bifid tongue (HP:0010297)2.68716107
36Hypothermia (HP:0002045)2.65648475
37Chronic hepatic failure (HP:0100626)2.64367703
38Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.57352268
39Amblyopia (HP:0000646)2.55552800
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.49040912
41Broad-based gait (HP:0002136)2.46383844
42Decreased central vision (HP:0007663)2.41644894
43Absent speech (HP:0001344)2.40794541
44Scotoma (HP:0000575)2.40704630
45Inability to walk (HP:0002540)2.39793464
46Hypoplastic labia majora (HP:0000059)2.38566800
47Genital tract atresia (HP:0001827)2.38319511
48Renal cortical cysts (HP:0000803)2.36575559
49Vaginal atresia (HP:0000148)2.36234277
50Abolished electroretinogram (ERG) (HP:0000550)2.35280713
51Abnormality of the renal medulla (HP:0100957)2.32863419
52Postaxial foot polydactyly (HP:0001830)2.31191982
53Abnormality of the labia minora (HP:0012880)2.28397053
54Cerebellar dysplasia (HP:0007033)2.25523210
55Tubular atrophy (HP:0000092)2.24957676
56Hyperventilation (HP:0002883)2.24906505
57Sensory axonal neuropathy (HP:0003390)2.24800243
58Mesomelia (HP:0003027)2.23602775
59Sclerocornea (HP:0000647)2.23446325
60Poor coordination (HP:0002370)2.23226234
61Progressive inability to walk (HP:0002505)2.22968831
62Buphthalmos (HP:0000557)2.19925953
63Keratoconus (HP:0000563)2.19821041
64Increased corneal curvature (HP:0100692)2.19821041
65Cutaneous finger syndactyly (HP:0010554)2.19720380
66Furrowed tongue (HP:0000221)2.18745149
67Absence seizures (HP:0002121)2.18380607
68Intestinal atresia (HP:0011100)2.17050592
69Labial hypoplasia (HP:0000066)2.14625188
70Asymmetry of the thorax (HP:0001555)2.13808017
71Severe visual impairment (HP:0001141)2.12879176
72Widely spaced teeth (HP:0000687)2.11568500
73Hemiparesis (HP:0001269)2.10962148
74Abnormality of the labia majora (HP:0012881)2.10590557
75Degeneration of the lateral corticospinal tracts (HP:0002314)2.09956118
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09956118
77Abnormality of the renal cortex (HP:0011035)2.08453214
78Scanning speech (HP:0002168)2.07656219
79True hermaphroditism (HP:0010459)2.07475929
80Abnormality of alanine metabolism (HP:0010916)2.07246711
81Hyperalaninemia (HP:0003348)2.07246711
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07246711
83Insidious onset (HP:0003587)2.06149284
84Termporal pattern (HP:0011008)2.06149284
85Osteomalacia (HP:0002749)2.04676999
86Protruding tongue (HP:0010808)2.04217184
87Male pseudohermaphroditism (HP:0000037)2.04206941
88Generalized tonic-clonic seizures (HP:0002069)2.02821518
89Postaxial hand polydactyly (HP:0001162)2.01352137
90Tubulointerstitial nephritis (HP:0001970)2.00500166
91Short foot (HP:0001773)2.00247212
92Small hand (HP:0200055)1.98973444
93Rhinitis (HP:0012384)1.98788563
94Hypoplastic female external genitalia (HP:0012815)1.98338802
95Anencephaly (HP:0002323)1.98052707
96Optic nerve hypoplasia (HP:0000609)1.97088475
97Lissencephaly (HP:0001339)1.96856071
98Congenital sensorineural hearing impairment (HP:0008527)1.96747126
99Abnormal drinking behavior (HP:0030082)1.96573670
100Polydipsia (HP:0001959)1.96573670
101Short tibia (HP:0005736)1.95987369
102Aqueductal stenosis (HP:0002410)1.95134070
103Increased number of teeth (HP:0011069)1.94871014
104Bony spicule pigmentary retinopathy (HP:0007737)1.94710475
105Focal seizures (HP:0007359)1.92749140
106Cone-rod dystrophy (HP:0000548)1.91815831
107Fair hair (HP:0002286)1.91653396
108Gaze-evoked nystagmus (HP:0000640)1.91628526
109Stage 5 chronic kidney disease (HP:0003774)1.90734353
110Abnormal rod and cone electroretinograms (HP:0008323)1.89538204
111Aplasia/Hypoplasia of the lens (HP:0008063)1.89264265
112Generalized hypopigmentation of hair (HP:0011358)1.88997266
113Lip pit (HP:0100267)1.88744528
114Dialeptic seizures (HP:0011146)1.87803669
115Macroorchidism (HP:0000053)1.87615552
116Pendular nystagmus (HP:0012043)1.86174150
117Clumsiness (HP:0002312)1.85957664
118Drooling (HP:0002307)1.85936200
119Excessive salivation (HP:0003781)1.85936200
120Abnormal hair whorl (HP:0010721)1.85271687
121Chromosomal breakage induced by crosslinking agents (HP:0003221)1.84944101
122Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84882752
123Thyroiditis (HP:0100646)1.84833324
124Cystic liver disease (HP:0006706)1.84609505
125Ankyloglossia (HP:0010296)1.84589703
126Oligodactyly (hands) (HP:0001180)1.84372270
127Colon cancer (HP:0003003)1.83403888
128Large for gestational age (HP:0001520)1.83118251
129Abnormality of incisor morphology (HP:0011063)1.81813117
130Preaxial hand polydactyly (HP:0001177)1.80027150
131Neoplasm of the tracheobronchial system (HP:0100552)1.79177549
132Retinitis pigmentosa (HP:0000510)1.78936805
133Gastrointestinal atresia (HP:0002589)1.78839672
134Constricted visual fields (HP:0001133)1.78134189
135Arterial tortuosity (HP:0005116)1.77800203
136Urinary bladder sphincter dysfunction (HP:0002839)1.77457589
137Decreased circulating renin level (HP:0003351)1.77296661
138Patellar aplasia (HP:0006443)1.76317859
139Congenital hepatic fibrosis (HP:0002612)1.75719111
140Thyroid-stimulating hormone excess (HP:0002925)1.74786777
141Specific learning disability (HP:0001328)1.74102496
142Pachygyria (HP:0001302)1.73952163
143Volvulus (HP:0002580)1.72893914
144Alveolar cell carcinoma (HP:0006519)1.71670554
145Stomach cancer (HP:0012126)1.71198530
146Median cleft lip (HP:0000161)1.70784962
147Aplasia/Hypoplasia of the patella (HP:0006498)1.70235264
148Narrow forehead (HP:0000341)1.70180324
149Blue irides (HP:0000635)1.67197465
150Hip dysplasia (HP:0001385)1.66516327
151Abnormality of calcium-phosphate metabolism (HP:0100530)1.65225803
152Intellectual disability, moderate (HP:0002342)1.64630498
153Tented upper lip vermilion (HP:0010804)1.62533073

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.59175251
2ICK3.76033043
3FGFR23.70778794
4MAP4K23.09939012
5ARAF2.94013283
6TNIK2.56897309
7CASK2.49621996
8NTRK32.28336913
9ACVR1B2.09148604
10AKT32.03501916
11FGFR32.02208095
12EPHA41.92889612
13PLK21.82155264
14MAP3K41.73515061
15TRIM281.73319921
16STK391.69155855
17INSRR1.63654816
18NUAK11.59927921
19PINK11.53007279
20OXSR11.47670915
21FES1.45121153
22BRAF1.42957386
23BCR1.41348039
24MAP3K131.36332757
25EPHB21.33010127
26MAP2K71.30276873
27MAPK131.30222651
28MST41.22741726
29SGK21.22115004
30PNCK1.21679622
31STK31.19322386
32PIM21.18245459
33TAOK21.15987001
34PAK31.15258598
35SGK2231.11642935
36SGK4941.11642935
37CAMKK21.10989574
38TLK11.09911906
39MAP3K141.07528479
40MAP2K61.02981486
41NTRK21.00856978
42STK38L1.00374586
43BRD40.96970731
44PKN10.94110965
45CSNK1G20.92093178
46MAP3K20.92092357
47ADRBK10.91976553
48WNK40.91852636
49PIK3CG0.91746503
50CSNK1G10.90755529
51BMPR20.87551804
52PAK60.85891661
53MKNK10.85361178
54BMPR1B0.85023425
55MKNK20.83773017
56WNK30.81381853
57MARK20.80549070
58PRKCE0.80353289
59ERBB30.79220216
60GRK10.79205973
61CSNK1G30.78979957
62SGK10.78120662
63NTRK10.77733578
64NEK60.77327087
65EPHA30.77154267
66TXK0.75437157
67CSNK1A1L0.75248877
68CAMK1G0.72525711
69EIF2AK20.70263247
70ADRBK20.70061240
71DYRK20.66350864
72CDK190.63655184
73WNK10.63447528
74BRSK20.63111780
75PLK30.63079107
76SGK30.62485065
77PRPF4B0.62259403
78TEC0.61933370
79NLK0.61182985
80STK160.60314095
81PHKG20.59632496
82PHKG10.59632496
83RAF10.58630000
84TGFBR10.57587459
85MARK10.57465099
86FER0.57247152
87STK110.56592772
88PRKG10.55994125
89ZAK0.55729936
90CAMK2A0.55704124
91IRAK20.55643992
92LATS10.55410907
93MAPK150.55003518
94MAP3K70.54544744
95TAOK30.54085083
96PRKAA20.51839192
97ERBB40.51443749
98MAP2K40.51400382
99CAMK2D0.51172091
100PRKCG0.51073587
101CAMK2B0.50854157
102PTK60.50712444
103RPS6KL10.50640205
104RPS6KC10.50640205
105MINK10.49906750
106PIK3CA0.49095516
107PLK40.48717968
108DAPK20.46081554
109PRKCH0.45698713
110PRKCQ0.45579197
111CSNK1D0.44273672
112RPS6KB10.43902928
113DYRK1A0.43382594
114CLK10.42623405
115VRK10.42552563
116RPS6KA60.42193964
117CDK30.42103721
118FGR0.41570189
119ROCK10.41406632
120RIPK40.41021647
121TAOK10.39306321
122CSNK1A10.38724838
123PRKAA10.38225239
124IRAK10.37817981
125RPS6KA50.37011712
126SIK20.36504159
127CDK50.35967921
128CAMK10.35900649
129CAMK2G0.35244124
130TRPM70.34753775
131PTK2B0.34641095
132OBSCN0.34628841
133PRKACA0.34205082
134UHMK10.34000711
135RPS6KA30.33544075
136TIE10.33455565
137MAP3K110.33325127
138TNK20.33160776
139CAMK1D0.32978079
140CAMK40.32373743
141PRKCB0.32287361
142PRKD20.32106946
143MAPK110.31960947
144ATM0.31532713
145PRKACB0.30707711
146PRKCZ0.28601237
147CHEK20.28319235
148EIF2AK30.27862451

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.49036558
2Nicotine addiction_Homo sapiens_hsa050333.37654822
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.62245216
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.50551981
5GABAergic synapse_Homo sapiens_hsa047272.47664044
6Circadian entrainment_Homo sapiens_hsa047132.36223381
7Morphine addiction_Homo sapiens_hsa050322.35012121
8Linoleic acid metabolism_Homo sapiens_hsa005912.31626496
9Glutamatergic synapse_Homo sapiens_hsa047242.19054555
10Olfactory transduction_Homo sapiens_hsa047402.15633973
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.02319007
12Insulin secretion_Homo sapiens_hsa049111.97327419
13Taste transduction_Homo sapiens_hsa047421.96101450
14Fanconi anemia pathway_Homo sapiens_hsa034601.86555709
15Caffeine metabolism_Homo sapiens_hsa002321.83206881
16Homologous recombination_Homo sapiens_hsa034401.81906089
17Nitrogen metabolism_Homo sapiens_hsa009101.81580936
18Type II diabetes mellitus_Homo sapiens_hsa049301.77067708
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76986726
20Serotonergic synapse_Homo sapiens_hsa047261.73679981
21Tryptophan metabolism_Homo sapiens_hsa003801.71510483
22Cholinergic synapse_Homo sapiens_hsa047251.71263835
23Dopaminergic synapse_Homo sapiens_hsa047281.71231968
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67532003
25Propanoate metabolism_Homo sapiens_hsa006401.66394572
26Synaptic vesicle cycle_Homo sapiens_hsa047211.64029071
27Protein export_Homo sapiens_hsa030601.57499045
28Selenocompound metabolism_Homo sapiens_hsa004501.56821644
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.51301248
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.50434999
31Axon guidance_Homo sapiens_hsa043601.50149691
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.44895728
33Long-term potentiation_Homo sapiens_hsa047201.44501441
34Amphetamine addiction_Homo sapiens_hsa050311.42902130
35Renin secretion_Homo sapiens_hsa049241.41655088
36Basal transcription factors_Homo sapiens_hsa030221.41394893
37Collecting duct acid secretion_Homo sapiens_hsa049661.40753622
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.38571511
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35760277
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30208839
41Salivary secretion_Homo sapiens_hsa049701.29416384
42Calcium signaling pathway_Homo sapiens_hsa040201.28150759
43Retinol metabolism_Homo sapiens_hsa008301.27014766
44Oxytocin signaling pathway_Homo sapiens_hsa049211.26934687
45Sulfur metabolism_Homo sapiens_hsa009201.25361067
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24183552
47Non-homologous end-joining_Homo sapiens_hsa034501.22181864
48cAMP signaling pathway_Homo sapiens_hsa040241.22018883
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18834962
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17163152
51Dorso-ventral axis formation_Homo sapiens_hsa043201.15871903
52Chemical carcinogenesis_Homo sapiens_hsa052041.14540992
53Long-term depression_Homo sapiens_hsa047301.09727736
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08463720
55Cocaine addiction_Homo sapiens_hsa050301.07966438
56Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06619948
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05816556
58RNA polymerase_Homo sapiens_hsa030201.05175067
59RNA degradation_Homo sapiens_hsa030181.04964836
60Circadian rhythm_Homo sapiens_hsa047101.03834628
61Oxidative phosphorylation_Homo sapiens_hsa001901.03156685
62Melanoma_Homo sapiens_hsa052181.01512394
63Inositol phosphate metabolism_Homo sapiens_hsa005621.01495470
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99771305
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97762024
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.96828806
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.95510425
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95379420
69Arachidonic acid metabolism_Homo sapiens_hsa005900.92628812
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92558673
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89973499
72Endometrial cancer_Homo sapiens_hsa052130.83841004
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83632120
74Regulation of autophagy_Homo sapiens_hsa041400.83056434
75Gastric acid secretion_Homo sapiens_hsa049710.82892102
76Prostate cancer_Homo sapiens_hsa052150.81474022
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.81333389
78Butanoate metabolism_Homo sapiens_hsa006500.81142622
79Ras signaling pathway_Homo sapiens_hsa040140.80624435
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79601208
81Glioma_Homo sapiens_hsa052140.79480621
82Glucagon signaling pathway_Homo sapiens_hsa049220.79230667
83ErbB signaling pathway_Homo sapiens_hsa040120.79182125
84Peroxisome_Homo sapiens_hsa041460.78967963
85Dilated cardiomyopathy_Homo sapiens_hsa054140.77891806
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76547103
87beta-Alanine metabolism_Homo sapiens_hsa004100.75339046
88Sphingolipid metabolism_Homo sapiens_hsa006000.74950844
89Vibrio cholerae infection_Homo sapiens_hsa051100.74593378
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72975311
91mTOR signaling pathway_Homo sapiens_hsa041500.70743427
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70580510
93Glycerolipid metabolism_Homo sapiens_hsa005610.69156783
94GnRH signaling pathway_Homo sapiens_hsa049120.68921248
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68615600
96ABC transporters_Homo sapiens_hsa020100.66968446
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66773920
98Estrogen signaling pathway_Homo sapiens_hsa049150.65089343
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63939724
100Choline metabolism in cancer_Homo sapiens_hsa052310.63407044
101Autoimmune thyroid disease_Homo sapiens_hsa053200.63077933
102Ether lipid metabolism_Homo sapiens_hsa005650.62169584
103Hedgehog signaling pathway_Homo sapiens_hsa043400.61690528
104Melanogenesis_Homo sapiens_hsa049160.60705258
105Fatty acid biosynthesis_Homo sapiens_hsa000610.59564269
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59207660
107Rheumatoid arthritis_Homo sapiens_hsa053230.59073570
108Fat digestion and absorption_Homo sapiens_hsa049750.58933690
109Fatty acid metabolism_Homo sapiens_hsa012120.58893719
110Ovarian steroidogenesis_Homo sapiens_hsa049130.57850312
111Thyroid hormone synthesis_Homo sapiens_hsa049180.57032948
112Fatty acid degradation_Homo sapiens_hsa000710.56752627
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56732019
114One carbon pool by folate_Homo sapiens_hsa006700.55633481
115Purine metabolism_Homo sapiens_hsa002300.55626552
116Tyrosine metabolism_Homo sapiens_hsa003500.55568850
117Histidine metabolism_Homo sapiens_hsa003400.54064034
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.52902040
119PPAR signaling pathway_Homo sapiens_hsa033200.52044298
120Steroid biosynthesis_Homo sapiens_hsa001000.50862440
121MAPK signaling pathway_Homo sapiens_hsa040100.50319451
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.49932546
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49598780
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48819411
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48572721
126Lysine degradation_Homo sapiens_hsa003100.47833201
127Mineral absorption_Homo sapiens_hsa049780.47644016
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47612613
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47585823
130Parkinsons disease_Homo sapiens_hsa050120.47570453
131Insulin signaling pathway_Homo sapiens_hsa049100.46195890
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46188527
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.45376898
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45239138
135Metabolic pathways_Homo sapiens_hsa011000.45087580
136Insulin resistance_Homo sapiens_hsa049310.44549899
137Huntingtons disease_Homo sapiens_hsa050160.43435452
138Rap1 signaling pathway_Homo sapiens_hsa040150.42966057
139Gap junction_Homo sapiens_hsa045400.42543018
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.40870654
141Pancreatic secretion_Homo sapiens_hsa049720.40290264
142Cardiac muscle contraction_Homo sapiens_hsa042600.40082609
143Fatty acid elongation_Homo sapiens_hsa000620.40031602
144Basal cell carcinoma_Homo sapiens_hsa052170.38638419
145Non-small cell lung cancer_Homo sapiens_hsa052230.37789058
146Starch and sucrose metabolism_Homo sapiens_hsa005000.36669114
147Renal cell carcinoma_Homo sapiens_hsa052110.36457279
148Pancreatic cancer_Homo sapiens_hsa052120.35747230
149AMPK signaling pathway_Homo sapiens_hsa041520.34806940
150Alzheimers disease_Homo sapiens_hsa050100.31676732
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.30043566

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