TBC1D3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.27005973
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.27005973
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03246485
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.94424535
5antigen processing and presentation of endogenous antigen (GO:0019883)4.93165324
6positive regulation of gamma-delta T cell activation (GO:0046645)4.69881526
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.58523246
8positive regulation by symbiont of host defense response (GO:0052509)4.52127878
9modulation by symbiont of host defense response (GO:0052031)4.52127878
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.52127878
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.52127878
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.52127878
13modulation by symbiont of host immune response (GO:0052553)4.52127878
14response to muramyl dipeptide (GO:0032495)4.21264056
15regulation of B cell receptor signaling pathway (GO:0050855)4.17242697
16macrophage activation involved in immune response (GO:0002281)4.05489544
17response to peptidoglycan (GO:0032494)4.04458595
18detection of bacterium (GO:0016045)4.00042038
19detection of other organism (GO:0098543)3.90915060
20mannose metabolic process (GO:0006013)3.88401969
21negative regulation of erythrocyte differentiation (GO:0045647)3.68876266
22neutrophil activation involved in immune response (GO:0002283)3.67296231
23Arp2/3 complex-mediated actin nucleation (GO:0034314)3.58598048
24regulation of ARF GTPase activity (GO:0032312)3.54191182
25B cell receptor signaling pathway (GO:0050853)3.51429420
26cellular extravasation (GO:0045123)3.50969885
27regulation of gamma-delta T cell activation (GO:0046643)3.48716828
28detection of external biotic stimulus (GO:0098581)3.48082579
29germinal center formation (GO:0002467)3.47825767
30regulation of mast cell degranulation (GO:0043304)3.39070779
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.35342391
32detection of molecule of bacterial origin (GO:0032490)3.33275801
33regulation of interferon-beta biosynthetic process (GO:0045357)3.30701696
34negative regulation of lymphocyte mediated immunity (GO:0002707)3.26572206
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.21143355
36NIK/NF-kappaB signaling (GO:0038061)3.21071573
37negative regulation of interleukin-12 production (GO:0032695)3.13164887
38defense response to protozoan (GO:0042832)3.10971065
39plasma lipoprotein particle assembly (GO:0034377)3.07281103
40regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07234708
41regulation of mast cell activation involved in immune response (GO:0033006)3.06470353
42regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.06315574
43negative regulation of cytokine production involved in immune response (GO:0002719)3.05583442
44immunoglobulin mediated immune response (GO:0016064)3.04756299
45positive thymic T cell selection (GO:0045059)3.02653370
46negative thymic T cell selection (GO:0045060)3.00903691
47regulation of leukocyte degranulation (GO:0043300)3.00602816
48response to interleukin-15 (GO:0070672)2.99053633
49positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.98622954
50detection of biotic stimulus (GO:0009595)2.95981146
51thymic T cell selection (GO:0045061)2.94709560
52negative regulation of leukocyte mediated immunity (GO:0002704)2.93800888
53leukocyte aggregation (GO:0070486)2.92969648
54negative regulation of toll-like receptor signaling pathway (GO:0034122)2.90752045
55negative regulation of innate immune response (GO:0045824)2.88704120
56neutrophil activation (GO:0042119)2.88409817
57regulation of gamma-delta T cell differentiation (GO:0045586)2.86606180
58response to protozoan (GO:0001562)2.86340749
59CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.85320314
60response to type I interferon (GO:0034340)2.85317852
61positive regulation of Cdc42 GTPase activity (GO:0043089)2.85079827
62protein-lipid complex assembly (GO:0065005)2.83671645
63regulation of B cell differentiation (GO:0045577)2.82502875
64microglial cell activation (GO:0001774)2.82298264
65type I interferon signaling pathway (GO:0060337)2.82149047
66cellular response to type I interferon (GO:0071357)2.82149047
67antigen processing and presentation via MHC class Ib (GO:0002475)2.82144831
68positive regulation of Rap GTPase activity (GO:0032854)2.82107252
69lipopolysaccharide-mediated signaling pathway (GO:0031663)2.79362638
70negative T cell selection (GO:0043383)2.78932760
71negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.77689049
72positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77681607
73response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.77512773
74response to host immune response (GO:0052572)2.77512773
75T cell selection (GO:0045058)2.76547950
76macrophage activation (GO:0042116)2.73591217
77granulocyte activation (GO:0036230)2.73127287
78myeloid cell activation involved in immune response (GO:0002275)2.72317333
79interferon-gamma-mediated signaling pathway (GO:0060333)2.70040596
80respiratory burst (GO:0045730)2.69685003
81positive regulation of B cell differentiation (GO:0045579)2.66899403
82regulation of dendritic cell antigen processing and presentation (GO:0002604)2.65699425
83actin filament polymerization (GO:0030041)2.65546623
84regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.63489198
85modulation by symbiont of host cellular process (GO:0044068)2.63161243
86positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.63029650
87regulation of RNA export from nucleus (GO:0046831)2.60356023
88regulation of cytokine secretion involved in immune response (GO:0002739)2.60217674
89response to host (GO:0075136)2.59645805
90response to host defenses (GO:0052200)2.59645805
91response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.59645805
92actin nucleation (GO:0045010)2.59108074
93N-acetylneuraminate metabolic process (GO:0006054)2.57766065
943-UTR-mediated mRNA stabilization (GO:0070935)2.57240395
95regulation of type I interferon-mediated signaling pathway (GO:0060338)2.57013011
96regulation of T-helper 2 cell differentiation (GO:0045628)2.56125961
97negative regulation of T cell mediated immunity (GO:0002710)2.53874745
98B cell homeostasis (GO:0001782)2.53182530
99leukocyte migration involved in inflammatory response (GO:0002523)2.49637871
100regulation of interferon-beta production (GO:0032648)2.48614976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.40304146
2MYC_22102868_ChIP-Seq_BL_Human3.15057087
3VDR_21846776_ChIP-Seq_THP-1_Human3.08814763
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.76316494
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.64649575
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.63479826
7TCF7_22412390_ChIP-Seq_EML_Mouse2.52422854
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.41097134
9KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.36719522
10E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.33686323
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29343559
12KDM2B_26808549_Chip-Seq_DND41_Human2.28928601
13MAF_26560356_Chip-Seq_TH1_Human2.27186901
14VDR_24763502_ChIP-Seq_THP-1_Human2.26881467
15LXR_22292898_ChIP-Seq_THP-1_Human2.26308893
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.24782362
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.19374884
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.16354901
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.12404936
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.11479202
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07681100
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07522975
23SPI1_23127762_ChIP-Seq_K562_Human2.06977344
24IRF8_21731497_ChIP-ChIP_J774_Mouse2.05916474
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.03258361
26MAF_26560356_Chip-Seq_TH2_Human2.01679433
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.00558758
28UTX_26944678_Chip-Seq_JUKART_Human1.98985566
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96090703
30SCL_19346495_ChIP-Seq_HPC-7_Human1.85107280
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83970145
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79759897
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78839381
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.77480714
35SPI1_23547873_ChIP-Seq_NB4_Human1.74083754
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.73649763
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73130591
38GATA1_19941827_ChIP-Seq_MEL_Mouse1.69133231
39MYB_26560356_Chip-Seq_TH1_Human1.67277063
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66115901
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64634202
42GATA1_19941826_ChIP-Seq_K562_Human1.62633174
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61861057
44TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59556477
45RACK7_27058665_Chip-Seq_MCF-7_Human1.57012221
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.54567681
47MYB_26560356_Chip-Seq_TH2_Human1.53055215
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51895411
49GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50053875
50KDM2B_26808549_Chip-Seq_K562_Human1.49456252
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47674744
52P68_20966046_ChIP-Seq_HELA_Human1.45979077
53BP1_19119308_ChIP-ChIP_Hs578T_Human1.44539170
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.43540349
55SMC4_20622854_ChIP-Seq_HELA_Human1.41349763
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.41336269
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39232116
58NCOR1_26117541_ChIP-Seq_K562_Human1.38899410
59RUNX_20019798_ChIP-Seq_JUKART_Human1.38721557
60BCL6_27268052_Chip-Seq_Bcells_Human1.35046760
61STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34970362
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33835676
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32158475
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31035726
65BCOR_27268052_Chip-Seq_Bcells_Human1.30753145
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29254051
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28922272
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27615344
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27055465
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21145117
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.20803253
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20594391
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19814437
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.19014867
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.17179513
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.17101234
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14317857
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.14229271
79* RUNX1_27514584_Chip-Seq_MCF-7_Human1.13116947
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11792746
81STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10859335
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09607579
83CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08936257
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08857198
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.08106079
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07735166
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07365196
88CREB1_26743006_Chip-Seq_LNCaP_Human1.07110600
89CIITA_25753668_ChIP-Seq_RAJI_Human1.06426060
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06172517
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05294074
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05104397
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04894225
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03024062
95UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01571605
96GATA2_19941826_ChIP-Seq_K562_Human1.01199867
97* GATA3_27048872_Chip-Seq_THYMUS_Human1.00261550
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00002969
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99549464
100TET1_21451524_ChIP-Seq_MESCs_Mouse0.99235540

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.81020637
2MP0003436_decreased_susceptibility_to3.92024664
3MP0003172_abnormal_lysosome_physiology3.40676329
4MP0001835_abnormal_antigen_presentation2.96528264
5MP0000685_abnormal_immune_system2.88554710
6MP0008260_abnormal_autophagy2.82399351
7MP0005387_immune_system_phenotype2.71061777
8MP0001790_abnormal_immune_system2.71061777
9MP0001800_abnormal_humoral_immune2.66392316
10MP0005058_abnormal_lysosome_morphology2.59596005
11MP0002419_abnormal_innate_immunity2.58028818
12MP0005025_abnormal_response_to2.40377438
13MP0003191_abnormal_cellular_cholesterol2.38908953
14MP0005000_abnormal_immune_tolerance2.35229114
15MP0005451_abnormal_body_composition2.21472066
16MP0003724_increased_susceptibility_to2.21281266
17MP0002723_abnormal_immune_serum2.20562196
18MP0002452_abnormal_antigen_presenting2.17241746
19MP0002420_abnormal_adaptive_immunity2.16340381
20MP0005671_abnormal_response_to2.16242367
21MP0005464_abnormal_platelet_physiology2.16042459
22MP0001819_abnormal_immune_cell2.13654174
23MP0003656_abnormal_erythrocyte_physiolo2.06831337
24MP0003763_abnormal_thymus_physiology1.99027527
25MP0003300_gastrointestinal_ulcer1.93153806
26MP0002396_abnormal_hematopoietic_system1.86450335
27MP0002398_abnormal_bone_marrow1.86355329
28MP0002405_respiratory_system_inflammati1.82187095
29MP0009785_altered_susceptibility_to1.81162317
30MP0004381_abnormal_hair_follicle1.81013718
31MP0001533_abnormal_skeleton_physiology1.72092936
32MP0000716_abnormal_immune_system1.71786330
33MP0010155_abnormal_intestine_physiology1.71362409
34MP0002132_abnormal_respiratory_system1.70127387
35MP0009278_abnormal_bone_marrow1.64366587
36MP0009333_abnormal_splenocyte_physiolog1.64306194
37MP0005076_abnormal_cell_differentiation1.61275314
38MP0004947_skin_inflammation1.59202507
39MP0002429_abnormal_blood_cell1.45548805
40MP0003705_abnormal_hypodermis_morpholog1.45027498
41MP0001851_eye_inflammation1.42792659
42MP0002722_abnormal_immune_system1.41943601
43MP0003866_abnormal_defecation1.41932836
44MP0005397_hematopoietic_system_phenotyp1.40942273
45MP0001545_abnormal_hematopoietic_system1.40942273
46MP0000689_abnormal_spleen_morphology1.40651130
47MP0006082_CNS_inflammation1.39397836
48MP0001873_stomach_inflammation1.38993490
49MP0005083_abnormal_biliary_tract1.38487091
50MP0001845_abnormal_inflammatory_respons1.37222533
51MP0009840_abnormal_foam_cell1.33080957
52MP0004264_abnormal_extraembryonic_tissu1.32007888
53MP0002148_abnormal_hypersensitivity_rea1.30428354
54MP0002138_abnormal_hepatobiliary_system1.29258899
55MP0003122_maternal_imprinting1.27165336
56MP0000465_gastrointestinal_hemorrhage1.25504478
57MP0003091_abnormal_cell_migration1.25353191
58MP0005409_darkened_coat_color1.25347575
59MP0000858_altered_metastatic_potential1.24957792
60MP0002332_abnormal_exercise_endurance1.22022336
61MP0001986_abnormal_taste_sensitivity1.20162020
62MP0003183_abnormal_peptide_metabolism1.19898793
63MP0008469_abnormal_protein_level1.16806971
64MP0000703_abnormal_thymus_morphology1.16736418
65MP0002998_abnormal_bone_remodeling1.12232637
66MP0002166_altered_tumor_susceptibility1.11603853
67MP0001663_abnormal_digestive_system1.09265782
68MP0001348_abnormal_lacrimal_gland1.08382874
69MP0003453_abnormal_keratinocyte_physiol1.07112946
70MP0001849_ear_inflammation1.02840731
71MP0000371_diluted_coat_color0.99909462
72MP0002933_joint_inflammation0.97527013
73MP0005310_abnormal_salivary_gland0.93356382
74MP0004808_abnormal_hematopoietic_stem0.92616495
75MP0004510_myositis0.91735725
76MP0005365_abnormal_bile_salt0.91568910
77MP0000015_abnormal_ear_pigmentation0.89927248
78MP0000609_abnormal_liver_physiology0.89172693
79MP0005023_abnormal_wound_healing0.82894716
80MP0003566_abnormal_cell_adhesion0.80308341
81MP0003045_fibrosis0.80138068
82MP0010329_abnormal_lipoprotein_level0.79755754
83MP0003879_abnormal_hair_cell0.78642435
84MP0003878_abnormal_ear_physiology0.75904342
85MP0005377_hearing/vestibular/ear_phenot0.75904342
86MP0000604_amyloidosis0.72532632
87MP0003828_pulmonary_edema0.66455820
88MP0004883_abnormal_blood_vessel0.65593672
89MP0005621_abnormal_cell_physiology0.65495188
90MP0009931_abnormal_skin_appearance0.65465919
91MP0002019_abnormal_tumor_incidence0.64932934
92MP0002822_catalepsy0.64157511
93MP0005381_digestive/alimentary_phenotyp0.63125722
94MP0003795_abnormal_bone_structure0.62787511
95MP0002060_abnormal_skin_morphology0.60704378
96MP0009115_abnormal_fat_cell0.60256490
97MP0005390_skeleton_phenotype0.59886617
98MP0009764_decreased_sensitivity_to0.59843080
99MP0005164_abnormal_response_to0.59090856
100MP0005375_adipose_tissue_phenotype0.58851942

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.23737043
2Myositis (HP:0100614)4.09623447
3Orchitis (HP:0100796)3.83407693
4Abnormality of macrophages (HP:0004311)3.81033272
5Gastrointestinal infarctions (HP:0005244)3.71583466
6Retrobulbar optic neuritis (HP:0100654)3.62787098
7Optic neuritis (HP:0100653)3.62787098
8Recurrent bacterial skin infections (HP:0005406)3.51946303
9Increased IgE level (HP:0003212)3.50455998
10Recurrent abscess formation (HP:0002722)3.47176164
11Increased connective tissue (HP:0009025)3.37887223
12Deep venous thrombosis (HP:0002625)3.34622769
13Prolonged bleeding time (HP:0003010)3.25312849
14Cellulitis (HP:0100658)3.21824708
15Recurrent gram-negative bacterial infections (HP:0005420)3.19086883
16Meningitis (HP:0001287)3.15115464
17Gingival bleeding (HP:0000225)3.03686060
18Vasculitis (HP:0002633)2.95893016
19Epistaxis (HP:0000421)2.89170454
20Agammaglobulinemia (HP:0004432)2.88940489
21Obstructive lung disease (HP:0006536)2.86718918
22Chronic obstructive pulmonary disease (HP:0006510)2.86718918
23Pustule (HP:0200039)2.82770559
24Recurrent fungal infections (HP:0002841)2.81717817
25Keratitis (HP:0000491)2.79631243
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.78969032
27Mediastinal lymphadenopathy (HP:0100721)2.78482619
28Keratoconjunctivitis sicca (HP:0001097)2.68303154
29Hemorrhage of the eye (HP:0011885)2.65367599
30Peritonitis (HP:0002586)2.55815273
31Pulmonary infiltrates (HP:0002113)2.53967937
32Gingivitis (HP:0000230)2.50819250
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.49217665
34Flat acetabular roof (HP:0003180)2.47619867
35Recurrent skin infections (HP:0001581)2.47390021
36Amyloidosis (HP:0011034)2.46900460
37Elevated erythrocyte sedimentation rate (HP:0003565)2.45286078
38Colitis (HP:0002583)2.43302890
39Chest pain (HP:0100749)2.43050088
40Gastrointestinal inflammation (HP:0004386)2.41460357
41Keratoconjunctivitis (HP:0001096)2.37496606
42Sepsis (HP:0100806)2.36476393
43Recurrent viral infections (HP:0004429)2.32090621
44Dysostosis multiplex (HP:0000943)2.30817685
45Spontaneous hematomas (HP:0007420)2.29614485
46Encephalitis (HP:0002383)2.28896368
47Inflammation of the large intestine (HP:0002037)2.28742218
48Recurrent cutaneous fungal infections (HP:0011370)2.26205729
49Chronic mucocutaneous candidiasis (HP:0002728)2.26205729
50Gastrointestinal stroma tumor (HP:0100723)2.24011580
51Abnormality of the common coagulation pathway (HP:0010990)2.23244513
52Menorrhagia (HP:0000132)2.22748658
53Slow saccadic eye movements (HP:0000514)2.22143114
54Panhypogammaglobulinemia (HP:0003139)2.19472062
55Increased serum ferritin (HP:0003281)2.17147442
56Pulmonary embolism (HP:0002204)2.16714098
57Purpura (HP:0000979)2.15745280
58Abnormality of the peritoneum (HP:0002585)2.14200215
59Granulocytopenia (HP:0001913)2.13101576
60Thin bony cortex (HP:0002753)2.12599833
61Hemoptysis (HP:0002105)2.12540296
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12337525
63Abnormality of polysaccharide metabolism (HP:0011012)2.12337525
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12337525
65Reticulocytosis (HP:0001923)2.10805173
66Urticaria (HP:0001025)2.09083825
67Lymphopenia (HP:0001888)2.07990441
68Mucopolysacchariduria (HP:0008155)2.07091523
69Urinary glycosaminoglycan excretion (HP:0003541)2.07091523
70Entropion (HP:0000621)2.06077949
71Joint hemorrhage (HP:0005261)2.04457983
72Cerebral aneurysm (HP:0004944)2.03382552
73Hypochromic anemia (HP:0001931)2.03211133
74Osteomyelitis (HP:0002754)2.02358948
75Emphysema (HP:0002097)2.02238559
76Recurrent sinusitis (HP:0011108)2.01939399
77Difficulty climbing stairs (HP:0003551)2.00781418
78Milia (HP:0001056)2.00661682
79Loss of speech (HP:0002371)2.00019525
80Acute hepatic failure (HP:0006554)1.99575372
81Supernumerary nipples (HP:0002558)1.99284294
82Thrombophlebitis (HP:0004418)1.98721283
83Abnormality of cells of the lymphoid lineage (HP:0012140)1.94919251
84Arterial thrombosis (HP:0004420)1.93471567
85Alopecia of scalp (HP:0002293)1.92822503
86Episodic fever (HP:0001954)1.92381527
87Urethral obstruction (HP:0000796)1.92086509
88Hypertriglyceridemia (HP:0002155)1.89432312
89Stomatitis (HP:0010280)1.89164183
90Papilloma (HP:0012740)1.87393700
91Verrucae (HP:0200043)1.87393700
92Thick nail (HP:0001805)1.86523615
93Abnormality of the pleura (HP:0002103)1.85384768
94Restrictive lung disease (HP:0002091)1.85031570
95Broad face (HP:0000283)1.83656115
96Abnormality of the fingertips (HP:0001211)1.82183480
97Leukocytosis (HP:0001974)1.81366824
98Poikilocytosis (HP:0004447)1.79886658
99Oligomenorrhea (HP:0000876)1.79050783
100Thickened calvaria (HP:0002684)1.78891594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.30998568
2ERN13.64877550
3RIPK43.36402565
4MAP4K13.26463774
5SIK22.99953110
6PRPF4B2.71227876
7MAP2K32.56215483
8SIK32.22581111
9IRAK42.20886524
10TYK22.12425412
11TRIB32.11954148
12SIK12.09513170
13MAP3K132.04521284
14CDK121.94179819
15BLK1.77650347
16TNK21.69886850
17MAP3K141.67252879
18TBK11.63109765
19FGFR41.62935164
20CSK1.58698860
21MARK21.58080458
22GRK61.56780960
23MAP3K31.52120432
24ZAP701.41693467
25FGR1.33662438
26MAP3K111.31535003
27IKBKE1.30552112
28EPHB11.27618721
29TAOK11.26664190
30WNK11.19926730
31STK161.19400904
32WNK41.15186622
33SYK1.13599393
34MAP3K71.12858421
35HCK1.12014846
36CSF1R1.11878209
37MARK31.11477305
38TAOK21.09599314
39BTK1.08542209
40MAP3K11.06474527
41ICK1.05631425
42JAK31.03938140
43CDC42BPA1.03863755
44FES1.00014720
45PRKD20.99452262
46MAP3K60.95470982
47IKBKB0.95011320
48IRAK30.90364346
49FGFR30.82732290
50TAOK30.81731591
51PDK10.81472304
52PKN20.81018862
53PDPK10.80359934
54LYN0.78732037
55SMG10.77968394
56LCK0.77168166
57JAK10.75878889
58DYRK1B0.75286051
59KIT0.74611957
60BRD40.72979718
61SGK30.71614052
62PTK60.71308492
63MAP2K60.71031135
64KSR20.70547186
65MAPK70.70389698
66YES10.68955740
67JAK20.68199744
68RIPK10.66886164
69MATK0.66860786
70IRAK20.66833129
71RPS6KL10.66063198
72RPS6KC10.66063198
73MAPK110.64872867
74HIPK20.63758775
75MTOR0.62618069
76NME10.61694581
77IRAK10.60829753
78RPS6KA20.55171317
79MST1R0.54118188
80CHUK0.54065922
81MAPK120.52169529
82EIF2AK10.50638002
83RPS6KA60.49610090
84BMX0.48391645
85ITK0.47961545
86RET0.45416016
87TXK0.44187783
88LRRK20.43271712
89PDGFRB0.42859295
90PRKCQ0.41928579
91PIM10.40992284
92LATS10.40455842
93STK100.40187828
94RAF10.39804803
95NEK20.39787585
96FYN0.39017406
97CDK40.38954162
98MAPK40.37894929
99DDR20.34901889
100TYRO30.33547706

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.61188551
2Staphylococcus aureus infection_Homo sapiens_hsa051502.51998279
3B cell receptor signaling pathway_Homo sapiens_hsa046622.48628811
4Osteoclast differentiation_Homo sapiens_hsa043802.39884519
5Leishmaniasis_Homo sapiens_hsa051402.37498403
6Allograft rejection_Homo sapiens_hsa053302.34031243
7Graft-versus-host disease_Homo sapiens_hsa053322.19097255
8Autoimmune thyroid disease_Homo sapiens_hsa053202.18095676
9Primary immunodeficiency_Homo sapiens_hsa053402.07514632
10Acute myeloid leukemia_Homo sapiens_hsa052211.80886321
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.80284437
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71863553
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.70519487
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.66184703
15Tuberculosis_Homo sapiens_hsa051521.65370666
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61796100
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.59564980
18Toxoplasmosis_Homo sapiens_hsa051451.59104885
19Type I diabetes mellitus_Homo sapiens_hsa049401.53421156
20T cell receptor signaling pathway_Homo sapiens_hsa046601.52911628
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52701713
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.51602017
23Influenza A_Homo sapiens_hsa051641.50359831
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49225634
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.49140397
26Antigen processing and presentation_Homo sapiens_hsa046121.46567375
27Non-small cell lung cancer_Homo sapiens_hsa052231.44707736
28Herpes simplex infection_Homo sapiens_hsa051681.44252208
29Viral myocarditis_Homo sapiens_hsa054161.42154707
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41806518
31Notch signaling pathway_Homo sapiens_hsa043301.41581292
32Asthma_Homo sapiens_hsa053101.36318502
33Measles_Homo sapiens_hsa051621.31631131
34TNF signaling pathway_Homo sapiens_hsa046681.28506931
35Hematopoietic cell lineage_Homo sapiens_hsa046401.27909944
36Chronic myeloid leukemia_Homo sapiens_hsa052201.26613067
37VEGF signaling pathway_Homo sapiens_hsa043701.25491421
38Chemokine signaling pathway_Homo sapiens_hsa040621.21815394
39Complement and coagulation cascades_Homo sapiens_hsa046101.16549655
40Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14961399
41Hepatitis B_Homo sapiens_hsa051611.14229657
42Adipocytokine signaling pathway_Homo sapiens_hsa049201.12234108
43Hepatitis C_Homo sapiens_hsa051601.11477007
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.11123620
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10387961
46Pancreatic cancer_Homo sapiens_hsa052121.04230546
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.99753176
48Platelet activation_Homo sapiens_hsa046110.99536149
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96744812
50Malaria_Homo sapiens_hsa051440.96272890
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95740519
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94897275
53Lysosome_Homo sapiens_hsa041420.92874612
54Apoptosis_Homo sapiens_hsa042100.91472478
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.90443697
56Inositol phosphate metabolism_Homo sapiens_hsa005620.90150595
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.88029244
58Choline metabolism in cancer_Homo sapiens_hsa052310.87889961
59GnRH signaling pathway_Homo sapiens_hsa049120.87608333
60Insulin resistance_Homo sapiens_hsa049310.87169570
61Prolactin signaling pathway_Homo sapiens_hsa049170.86867967
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.86026235
63Endocytosis_Homo sapiens_hsa041440.82523211
64Legionellosis_Homo sapiens_hsa051340.81989451
65Endometrial cancer_Homo sapiens_hsa052130.81269573
66Renal cell carcinoma_Homo sapiens_hsa052110.80237334
67Epstein-Barr virus infection_Homo sapiens_hsa051690.78336486
68African trypanosomiasis_Homo sapiens_hsa051430.78306625
69Phagosome_Homo sapiens_hsa041450.77685234
70HTLV-I infection_Homo sapiens_hsa051660.74333780
71Shigellosis_Homo sapiens_hsa051310.71109484
72mTOR signaling pathway_Homo sapiens_hsa041500.68028800
73Amoebiasis_Homo sapiens_hsa051460.67149677
74Pertussis_Homo sapiens_hsa051330.65317547
75Insulin signaling pathway_Homo sapiens_hsa049100.63432647
76FoxO signaling pathway_Homo sapiens_hsa040680.62997550
77MAPK signaling pathway_Homo sapiens_hsa040100.62394371
78Bladder cancer_Homo sapiens_hsa052190.61580450
79Salmonella infection_Homo sapiens_hsa051320.61100353
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59183203
81Small cell lung cancer_Homo sapiens_hsa052220.57541553
82PPAR signaling pathway_Homo sapiens_hsa033200.57079231
83HIF-1 signaling pathway_Homo sapiens_hsa040660.56616405
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.55470855
85Lysine degradation_Homo sapiens_hsa003100.54630731
86Rheumatoid arthritis_Homo sapiens_hsa053230.53695638
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.53522897
88Viral carcinogenesis_Homo sapiens_hsa052030.52510568
89ErbB signaling pathway_Homo sapiens_hsa040120.52341701
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51193323
91Thyroid cancer_Homo sapiens_hsa052160.50785367
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50447781
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49965830
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48459294
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47918040
96Prostate cancer_Homo sapiens_hsa052150.47881195
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46361847
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45714204
99ABC transporters_Homo sapiens_hsa020100.45163815
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43617364

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