TBC1D3E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.97171384
2antigen processing and presentation of endogenous antigen (GO:0019883)5.26905627
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.21103586
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.80803121
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.77968627
6negative regulation of cell killing (GO:0031342)4.77968627
7cellular response to type I interferon (GO:0071357)4.75468351
8type I interferon signaling pathway (GO:0060337)4.75468351
9response to type I interferon (GO:0034340)4.70096712
10positive regulation by symbiont of host defense response (GO:0052509)4.47636326
11modulation by symbiont of host defense response (GO:0052031)4.47636326
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.47636326
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.47636326
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.47636326
15modulation by symbiont of host immune response (GO:0052553)4.47636326
16mature B cell differentiation involved in immune response (GO:0002313)4.40959391
17positive regulation of gamma-delta T cell activation (GO:0046645)4.23831265
18fusion of sperm to egg plasma membrane (GO:0007342)4.11751628
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.02674423
20immunoglobulin mediated immune response (GO:0016064)4.01146868
21macrophage activation involved in immune response (GO:0002281)3.88125862
22regulation of B cell receptor signaling pathway (GO:0050855)3.77578721
23interferon-gamma-mediated signaling pathway (GO:0060333)3.74587359
24natural killer cell differentiation (GO:0001779)3.67366128
25mature B cell differentiation (GO:0002335)3.65516974
26detection of bacterium (GO:0016045)3.62363680
27response to host immune response (GO:0052572)3.55924935
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.55924935
29response to peptidoglycan (GO:0032494)3.53370458
30mucosal-associated lymphoid tissue development (GO:0048537)3.53124087
31Peyers patch development (GO:0048541)3.53124087
32detection of other organism (GO:0098543)3.48811893
33positive regulation of type 2 immune response (GO:0002830)3.48321404
34negative regulation of erythrocyte differentiation (GO:0045647)3.45611597
35regulation of T-helper 2 cell differentiation (GO:0045628)3.45376040
36positive thymic T cell selection (GO:0045059)3.45358618
37phosphatidylethanolamine biosynthetic process (GO:0006646)3.43496359
38negative regulation of interleukin-12 production (GO:0032695)3.37470639
39positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.37057650
40regulation of interferon-beta biosynthetic process (GO:0045357)3.31120006
41sperm motility (GO:0030317)3.28777788
42response to host (GO:0075136)3.27055530
43response to host defenses (GO:0052200)3.27055530
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.27055530
45positive regulation of T cell mediated cytotoxicity (GO:0001916)3.22100354
46defense response to protozoan (GO:0042832)3.21634444
47negative regulation of cytokine production involved in immune response (GO:0002719)3.21023105
48regulation of gamma-delta T cell activation (GO:0046643)3.20832157
49NIK/NF-kappaB signaling (GO:0038061)3.20305297
50detection of external biotic stimulus (GO:0098581)3.20201122
51regulation of T cell mediated cytotoxicity (GO:0001914)3.18182203
52acrosome reaction (GO:0007340)3.18000794
53response to interferon-beta (GO:0035456)3.17661420
54regulation of dendritic cell antigen processing and presentation (GO:0002604)3.13815748
55phosphatidylethanolamine metabolic process (GO:0046337)3.06087965
56negative regulation of lymphocyte mediated immunity (GO:0002707)3.05754637
57detection of molecule of bacterial origin (GO:0032490)3.05162727
58regulation of B cell differentiation (GO:0045577)3.05013462
59B cell mediated immunity (GO:0019724)3.03968557
60myeloid cell activation involved in immune response (GO:0002275)3.01451196
61germinal center formation (GO:0002467)3.00944909
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.98436531
63seminiferous tubule development (GO:0072520)2.98182043
64Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97589414
65cellular response to interferon-gamma (GO:0071346)2.91798783
66B cell receptor signaling pathway (GO:0050853)2.91317203
67cellular response to interferon-beta (GO:0035458)2.91070625
68response to protozoan (GO:0001562)2.90666656
69response to muramyl dipeptide (GO:0032495)2.90114952
70regulation of mast cell degranulation (GO:0043304)2.88310697
71negative regulation of leukocyte mediated immunity (GO:0002704)2.87659851
72sperm capacitation (GO:0048240)2.84557210
73lipopolysaccharide-mediated signaling pathway (GO:0031663)2.84508603
74regulation of cytokine secretion involved in immune response (GO:0002739)2.84487271
75plasma membrane fusion (GO:0045026)2.84220317
76positive regulation of interleukin-4 production (GO:0032753)2.84008593
77regulation of interferon-alpha production (GO:0032647)2.80222277
78positive regulation of B cell differentiation (GO:0045579)2.78315501
79positive regulation of interleukin-17 production (GO:0032740)2.77613129
80response to interferon-gamma (GO:0034341)2.77019844
81negative regulation of granulocyte differentiation (GO:0030853)2.74385903
82hemoglobin metabolic process (GO:0020027)2.73962644
83positive regulation of interferon-alpha production (GO:0032727)2.73748961
84regulation of Rab GTPase activity (GO:0032313)2.73737800
85positive regulation of Rab GTPase activity (GO:0032851)2.73737800
86positive regulation of macrophage cytokine production (GO:0060907)2.72585954
87neutrophil activation involved in immune response (GO:0002283)2.71964498
88response to interleukin-15 (GO:0070672)2.71923938
89regulation of antigen processing and presentation (GO:0002577)2.70923388
90negative regulation of alpha-beta T cell activation (GO:0046636)2.68668710
91macrophage activation (GO:0042116)2.67848005
92detection of biotic stimulus (GO:0009595)2.67786665
93positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66225577
94regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.65637075
95response to interferon-alpha (GO:0035455)2.64140052
96regulation of type 2 immune response (GO:0002828)2.63529172
97megakaryocyte development (GO:0035855)2.63518987
98regulation of gamma-delta T cell differentiation (GO:0045586)2.60877018
99positive regulation of antigen processing and presentation (GO:0002579)2.60386261
100regulation of mast cell activation involved in immune response (GO:0033006)2.59410324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.07631273
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.90246423
3GATA1_19941826_ChIP-Seq_K562_Human2.64595700
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64455941
5VDR_21846776_ChIP-Seq_THP-1_Human2.62611186
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.56280647
7MYC_22102868_ChIP-Seq_BL_Human2.52762119
8VDR_24763502_ChIP-Seq_THP-1_Human2.52186917
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.45775056
10LXR_22292898_ChIP-Seq_THP-1_Human2.43793590
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.41026739
12SCL_19346495_ChIP-Seq_HPC-7_Human2.39884149
13MAF_26560356_Chip-Seq_TH1_Human2.33988682
14RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.33678190
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.25617545
16E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.18770186
17TCF7_22412390_ChIP-Seq_EML_Mouse2.18125513
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.16593737
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16269035
20ELF1_20517297_ChIP-Seq_JURKAT_Human2.15735198
21RUNX_20019798_ChIP-Seq_JUKART_Human2.14200773
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08868401
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04647300
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.00929276
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.00904970
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.95595111
27MYB_26560356_Chip-Seq_TH2_Human1.95449025
28UTX_26944678_Chip-Seq_JUKART_Human1.95282401
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95018457
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94655231
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.94482173
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94435280
33KDM2B_26808549_Chip-Seq_DND41_Human1.93394561
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.88469674
35MAF_26560356_Chip-Seq_TH2_Human1.86348450
36BCL6_27268052_Chip-Seq_Bcells_Human1.86230713
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85112425
38SPI1_23127762_ChIP-Seq_K562_Human1.83736432
39BCOR_27268052_Chip-Seq_Bcells_Human1.79540467
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.75396896
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75354966
42MYB_26560356_Chip-Seq_TH1_Human1.73845331
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.68186531
44VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.68077494
45SPI1_23547873_ChIP-Seq_NB4_Human1.66846700
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.64386055
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.63899110
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58244436
49GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58241541
50P68_20966046_ChIP-Seq_HELA_Human1.57382275
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53321322
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51332943
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49235433
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48745988
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48331890
56GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46747127
57GATA2_19941826_ChIP-Seq_K562_Human1.46444547
58GATA3_27048872_Chip-Seq_THYMUS_Human1.44027933
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41900138
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41699359
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40734093
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40396656
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.40225625
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39617125
65RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39318797
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38831714
67VDR_24787735_ChIP-Seq_THP-1_Human1.38725435
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36749719
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34609605
70GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31985185
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30868154
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30739712
73NCOR1_26117541_ChIP-Seq_K562_Human1.30523637
74SMC4_20622854_ChIP-Seq_HELA_Human1.29389787
75TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28554871
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27687844
77YY1_22570637_ChIP-Seq_MALME-3M_Human1.27333140
78P300_27268052_Chip-Seq_Bcells_Human1.26998856
79PHF8_20622854_ChIP-Seq_HELA_Human1.21551820
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21492681
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19885154
82E2F1_20622854_ChIP-Seq_HELA_Human1.18840073
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15114985
84PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11934245
85EGR1_19374776_ChIP-ChIP_THP-1_Human1.09847347
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.09433827
87TP63_22573176_ChIP-Seq_HFKS_Human1.08915338
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07958508
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07047476
90NANOG_20526341_ChIP-Seq_ESCs_Human1.05926431
91FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05701898
92RACK7_27058665_Chip-Seq_MCF-7_Human1.04707558
93CTCF_21964334_Chip-Seq_Bcells_Human1.03623602
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03192803
95RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02599834
96SA1_27219007_Chip-Seq_Bcells_Human1.02266085
97GATA2_21666600_ChIP-Seq_HMVEC_Human1.00283082
98SPI1_20517297_ChIP-Seq_HL60_Human1.00188237
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00105785
100GATA1_22025678_ChIP-Seq_K562_Human1.00091663

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.92121338
2MP0001835_abnormal_antigen_presentation3.61583905
3MP0003436_decreased_susceptibility_to3.51798574
4MP0005410_abnormal_fertilization3.36038660
5MP0000685_abnormal_immune_system2.91493383
6MP0003724_increased_susceptibility_to2.89405833
7MP0009278_abnormal_bone_marrow2.89238841
8MP0001790_abnormal_immune_system2.86224917
9MP0005387_immune_system_phenotype2.86224917
10MP0005000_abnormal_immune_tolerance2.83245507
11MP0009785_altered_susceptibility_to2.77760177
12MP0003191_abnormal_cellular_cholesterol2.71776742
13MP0005671_abnormal_response_to2.71491675
14MP0005025_abnormal_response_to2.62164371
15MP0002132_abnormal_respiratory_system2.52041900
16MP0002419_abnormal_innate_immunity2.50819347
17MP0001800_abnormal_humoral_immune2.46305300
18MP0001545_abnormal_hematopoietic_system2.41691565
19MP0005397_hematopoietic_system_phenotyp2.41691565
20MP0002148_abnormal_hypersensitivity_rea2.39377018
21MP0002723_abnormal_immune_serum2.37195456
22MP0005083_abnormal_biliary_tract2.27728851
23MP0005464_abnormal_platelet_physiology2.24742368
24MP0002452_abnormal_antigen_presenting2.24277861
25MP0004510_myositis2.19887710
26MP0002420_abnormal_adaptive_immunity2.17185304
27MP0001819_abnormal_immune_cell2.13982544
28MP0005310_abnormal_salivary_gland2.02864291
29MP0003300_gastrointestinal_ulcer1.98361386
30MP0001348_abnormal_lacrimal_gland1.97358178
31MP0009840_abnormal_foam_cell1.94336386
32MP0002398_abnormal_bone_marrow1.85882139
33MP0009333_abnormal_splenocyte_physiolog1.85462286
34MP0005451_abnormal_body_composition1.81024097
35MP0002396_abnormal_hematopoietic_system1.80069611
36MP0003763_abnormal_thymus_physiology1.79152205
37MP0002405_respiratory_system_inflammati1.76640283
38MP0003172_abnormal_lysosome_physiology1.72533382
39MP0002138_abnormal_hepatobiliary_system1.72476160
40MP0000716_abnormal_immune_system1.70967947
41MP0006082_CNS_inflammation1.67233345
42MP0005377_hearing/vestibular/ear_phenot1.65035915
43MP0003878_abnormal_ear_physiology1.65035915
44MP0001533_abnormal_skeleton_physiology1.60938075
45MP0004947_skin_inflammation1.53856435
46MP0009764_decreased_sensitivity_to1.50858051
47MP0001845_abnormal_inflammatory_respons1.46781791
48MP0002722_abnormal_immune_system1.45997514
49MP0008469_abnormal_protein_level1.45779404
50MP0002429_abnormal_blood_cell1.43629103
51MP0010155_abnormal_intestine_physiology1.38053969
52MP0000689_abnormal_spleen_morphology1.37709951
53MP0003866_abnormal_defecation1.36038112
54MP0003656_abnormal_erythrocyte_physiolo1.32781009
55MP0000465_gastrointestinal_hemorrhage1.23402286
56MP0000703_abnormal_thymus_morphology1.20164702
57MP0008874_decreased_physiological_sensi1.12919132
58MP0004883_abnormal_blood_vessel1.09775974
59MP0002653_abnormal_ependyma_morphology1.06113006
60MP0001853_heart_inflammation1.04856529
61MP0005164_abnormal_response_to1.03270976
62MP0003075_altered_response_to1.03182783
63MP0002998_abnormal_bone_remodeling1.00063479
64MP0001873_stomach_inflammation0.98254661
65MP0003183_abnormal_peptide_metabolism0.97672329
66MP0000858_altered_metastatic_potential0.90889508
67MP0008004_abnormal_stomach_pH0.87631755
68MP0001851_eye_inflammation0.87629135
69MP0008260_abnormal_autophagy0.86361855
70MP0002933_joint_inflammation0.83930406
71MP0005379_endocrine/exocrine_gland_phen0.83736870
72MP0003448_altered_tumor_morphology0.83731034
73MP0003091_abnormal_cell_migration0.83022691
74MP0000249_abnormal_blood_vessel0.82673995
75MP0003828_pulmonary_edema0.82111812
76MP0002822_catalepsy0.78422289
77MP0003698_abnormal_male_reproductive0.78409480
78MP0009763_increased_sensitivity_to0.75860746
79MP0005166_decreased_susceptibility_to0.75427467
80MP0005666_abnormal_adipose_tissue0.75290271
81MP0004808_abnormal_hematopoietic_stem0.74431537
82MP0000343_altered_response_to0.74406387
83MP0009765_abnormal_xenobiotic_induced0.71290169
84MP0005390_skeleton_phenotype0.70272752
85MP0002166_altered_tumor_susceptibility0.69601994
86MP0001663_abnormal_digestive_system0.68249594
87MP0002006_tumorigenesis0.67903176
88MP0002019_abnormal_tumor_incidence0.67663422
89MP0005670_abnormal_white_adipose0.64170037
90MP0005535_abnormal_body_temperature0.64131272
91MP0003879_abnormal_hair_cell0.63597682
92MP0003453_abnormal_keratinocyte_physiol0.62893537
93MP0000604_amyloidosis0.62078673
94MP0000678_abnormal_parathyroid_gland0.61489336
95MP0001929_abnormal_gametogenesis0.60698187
96MP0005623_abnormal_meninges_morphology0.59896818
97MP0005165_increased_susceptibility_to0.53265174
98MP0006054_spinal_hemorrhage0.52803067
99MP0005319_abnormal_enzyme/_coenzyme0.52368502
100MP0005375_adipose_tissue_phenotype0.51673200

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)5.63248871
2Orchitis (HP:0100796)5.26574980
3Elevated erythrocyte sedimentation rate (HP:0003565)4.65315759
4Retrobulbar optic neuritis (HP:0100654)4.56574323
5Optic neuritis (HP:0100653)4.56574323
6Severe visual impairment (HP:0001141)4.18033629
7Recurrent abscess formation (HP:0002722)3.88806691
8Cellulitis (HP:0100658)3.84970040
9Abnormality of macrophages (HP:0004311)3.83246955
10Increased IgE level (HP:0003212)3.73981609
11Eczematoid dermatitis (HP:0000976)3.72833257
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.68643368
13Meningitis (HP:0001287)3.64218598
14Vasculitis (HP:0002633)3.59119420
15Recurrent bacterial skin infections (HP:0005406)3.48828567
16Gastrointestinal infarctions (HP:0005244)3.46449923
17Nasal polyposis (HP:0100582)3.44118265
18Abnormality of the heme biosynthetic pathway (HP:0010472)3.36424867
19Stomatitis (HP:0010280)3.35220421
20Asymmetric septal hypertrophy (HP:0001670)3.33568661
21Mediastinal lymphadenopathy (HP:0100721)3.24995905
22Hypochromic microcytic anemia (HP:0004840)3.22416289
23Keratoconjunctivitis sicca (HP:0001097)3.21067785
24Colitis (HP:0002583)3.16469498
25Pulmonary infiltrates (HP:0002113)3.15465844
26Tubulointerstitial nephritis (HP:0001970)3.15283473
27Fatigue (HP:0012378)3.13493837
28Obstructive lung disease (HP:0006536)3.09319136
29Chronic obstructive pulmonary disease (HP:0006510)3.09319136
30Amyloidosis (HP:0011034)3.04484900
31Hypochromic anemia (HP:0001931)3.00662591
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.00599777
33Inflammation of the large intestine (HP:0002037)3.00391672
34Abnormality of the nasal mucosa (HP:0000433)2.95754629
35Keratoconjunctivitis (HP:0001096)2.88966648
36Encephalitis (HP:0002383)2.87237273
37Gastrointestinal inflammation (HP:0004386)2.83345302
38Recurrent fungal infections (HP:0002841)2.82951827
39Gastrointestinal stroma tumor (HP:0100723)2.82617336
40Pustule (HP:0200039)2.81535287
41Agammaglobulinemia (HP:0004432)2.80625831
42Granulocytopenia (HP:0001913)2.75723616
43Gingival bleeding (HP:0000225)2.75166397
44Prolonged bleeding time (HP:0003010)2.74982978
45Autoimmune thrombocytopenia (HP:0001973)2.70230452
46Peritonitis (HP:0002586)2.68583512
47Recurrent viral infections (HP:0004429)2.66145614
48Leukocytosis (HP:0001974)2.63644774
49Recurrent gram-negative bacterial infections (HP:0005420)2.63393074
50Epistaxis (HP:0000421)2.62970812
51Hypergammaglobulinemia (HP:0010702)2.61775300
52Increased IgM level (HP:0003496)2.60419159
53Abnormality of the peritoneum (HP:0002585)2.59156590
54Lymphopenia (HP:0001888)2.58184740
55Abnormality of cells of the lymphoid lineage (HP:0012140)2.50739174
56Recurrent sinusitis (HP:0011108)2.50497505
57Increased cerebral lipofuscin (HP:0011813)2.49643424
58Recurrent skin infections (HP:0001581)2.49430232
59Urticaria (HP:0001025)2.48212327
60Gingivitis (HP:0000230)2.46558444
61Microcytic anemia (HP:0001935)2.45545003
62Hypertensive crisis (HP:0100735)2.45390733
63Emphysema (HP:0002097)2.44325366
64Chest pain (HP:0100749)2.42065033
65Abnormality of T cell physiology (HP:0011840)2.38331441
66Glomerulopathy (HP:0100820)2.37722368
67Episodic fever (HP:0001954)2.34637291
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.33851535
69Autoimmune hemolytic anemia (HP:0001890)2.26589328
70IgM deficiency (HP:0002850)2.24816355
71Osteomyelitis (HP:0002754)2.24411024
72Abnormality of T cells (HP:0002843)2.23804107
73Thoracic kyphosis (HP:0002942)2.20650885
74Reticulocytosis (HP:0001923)2.20055745
75Abnormality of the pleura (HP:0002103)2.19024464
76Hemoptysis (HP:0002105)2.18019795
77Increased serum ferritin (HP:0003281)2.17136227
78Acute hepatic failure (HP:0006554)2.14876266
79Arterial thrombosis (HP:0004420)2.12642723
80Chronic mucocutaneous candidiasis (HP:0002728)2.12258417
81Recurrent cutaneous fungal infections (HP:0011370)2.12258417
82Recurrent pneumonia (HP:0006532)2.12211582
83Abnormality of B cell number (HP:0010975)2.11169783
84Interstitial pulmonary disease (HP:0006530)2.11023323
85Slow saccadic eye movements (HP:0000514)2.09241888
86Recurrent bronchitis (HP:0002837)2.07622538
87Recurrent lower respiratory tract infections (HP:0002783)2.07189018
88Skin rash (HP:0000988)2.06535173
89Polyneuropathy (HP:0001271)2.05911773
90Arthralgia (HP:0002829)2.04910847
91Chronic otitis media (HP:0000389)2.03954681
92Petechiae (HP:0000967)2.03940387
93Vertigo (HP:0002321)2.02549027
94Abnormality of iron homeostasis (HP:0011031)2.01491455
95Anorexia (HP:0002039)1.99767942
96Panhypogammaglobulinemia (HP:0003139)1.98947391
97Aplasia/Hypoplasia of the thymus (HP:0010515)1.91308252
98Abnormality of the fingertips (HP:0001211)1.88475708
99Acne (HP:0001061)1.88373922
100Spontaneous hematomas (HP:0007420)1.87685091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.11474242
2MAP4K13.72515990
3PRPF4B3.61654207
4MAP3K113.15560259
5RIPK43.08243779
6TAOK22.69588924
7TAOK32.53307016
8MAP2K32.42301596
9TNK22.22396489
10DDR22.20684383
11TESK12.14755984
12TBK12.14051874
13PLK41.92335734
14BLK1.91580526
15TYK21.90841137
16KIT1.83803236
17TAOK11.75094457
18TESK21.69678807
19JAK31.68302871
20IKBKE1.63430744
21ZAP701.58005025
22FLT31.55826387
23SIK21.53548626
24MAP3K131.51913084
25MAP3K11.50163058
26DYRK1B1.49821829
27MAP3K31.48855010
28IKBKB1.48498990
29CSF1R1.46487119
30SYK1.40616822
31FES1.37662254
32IRAK41.34803868
33MAP3K141.34221303
34STK381.29099289
35CSK1.24210825
36PTK2B1.19330774
37BMX1.17331264
38HCK1.14634597
39JAK11.13506668
40BTK1.13274285
41GRK71.12822544
42PRKG21.04217873
43PDK11.00257513
44JAK20.96223636
45KSR20.93482347
46PDPK10.92625675
47BRD40.91882577
48PRKD20.91286881
49RPS6KC10.90950596
50RPS6KL10.90950596
51EPHB10.88858788
52LYN0.88572493
53RPS6KA20.87691320
54SIK30.86176511
55HIPK20.85810608
56GRK60.84600895
57FGR0.84421809
58LCK0.82771687
59CDC42BPA0.81206239
60MATK0.79487682
61MAPK110.77875514
62CDK120.77687038
63MARK20.74673197
64PRKCQ0.74161632
65RPS6KA60.73083794
66MARK30.72336000
67TRIB30.71923231
68IRAK30.71549910
69SIK10.71044289
70CHUK0.70178284
71MAP2K20.67748168
72PIM10.67085303
73CDK40.63063982
74INSRR0.63048683
75MAP3K50.61863814
76ARAF0.61296835
77MOS0.57775368
78TXK0.54115436
79MAPK120.53116017
80MAP3K90.52670110
81MAP3K80.52146654
82PRKCH0.51124208
83CAMK1G0.48248941
84STK100.45856227
85BMPR20.44453724
86MAP3K70.44000618
87RPS6KA10.41180211
88MAPK70.40422249
89DMPK0.40403776
90PIK3CG0.38973150
91FYN0.34794978
92MAPK40.31602403
93KDR0.31096013
94MAPKAPK20.30954991
95IRAK10.29586733
96NME20.29406814
97ITK0.29377781
98BRAF0.29151955
99MTOR0.28483014
100NEK90.27704361

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.61145717
2Graft-versus-host disease_Homo sapiens_hsa053323.30813461
3Autoimmune thyroid disease_Homo sapiens_hsa053203.25209912
4Type I diabetes mellitus_Homo sapiens_hsa049402.69855886
5Primary immunodeficiency_Homo sapiens_hsa053402.65199684
6Leishmaniasis_Homo sapiens_hsa051402.59750581
7Antigen processing and presentation_Homo sapiens_hsa046122.43539042
8Viral myocarditis_Homo sapiens_hsa054162.31645677
9Osteoclast differentiation_Homo sapiens_hsa043802.26574920
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.24480976
11B cell receptor signaling pathway_Homo sapiens_hsa046622.15495482
12Asthma_Homo sapiens_hsa053102.12718988
13Staphylococcus aureus infection_Homo sapiens_hsa051502.02128052
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.99851847
15Influenza A_Homo sapiens_hsa051641.98936129
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.95413692
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90649612
18Herpes simplex infection_Homo sapiens_hsa051681.87167995
19Measles_Homo sapiens_hsa051621.82400743
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.81972513
21Toxoplasmosis_Homo sapiens_hsa051451.75668874
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75590037
23Tuberculosis_Homo sapiens_hsa051521.67704637
24Acute myeloid leukemia_Homo sapiens_hsa052211.67037345
25Hematopoietic cell lineage_Homo sapiens_hsa046401.60716498
26Malaria_Homo sapiens_hsa051441.48924847
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.43678394
28African trypanosomiasis_Homo sapiens_hsa051431.43656691
29TNF signaling pathway_Homo sapiens_hsa046681.42160115
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41105094
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40741635
32T cell receptor signaling pathway_Homo sapiens_hsa046601.39607806
33Other glycan degradation_Homo sapiens_hsa005111.34126243
34Hepatitis C_Homo sapiens_hsa051601.22870006
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.22331692
36Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13125527
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12012663
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08833200
39Legionellosis_Homo sapiens_hsa051341.07651527
40Rheumatoid arthritis_Homo sapiens_hsa053231.06511141
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.06285980
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04938001
43Chemokine signaling pathway_Homo sapiens_hsa040621.04624769
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03493027
45Apoptosis_Homo sapiens_hsa042101.01642686
46Hepatitis B_Homo sapiens_hsa051611.00978816
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99997559
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97051121
49Epstein-Barr virus infection_Homo sapiens_hsa051690.94898892
50Phagosome_Homo sapiens_hsa041450.92547352
51VEGF signaling pathway_Homo sapiens_hsa043700.92149459
52Platelet activation_Homo sapiens_hsa046110.91046182
53Pertussis_Homo sapiens_hsa051330.87950853
54Prolactin signaling pathway_Homo sapiens_hsa049170.80602764
55Non-small cell lung cancer_Homo sapiens_hsa052230.78183893
56Pancreatic cancer_Homo sapiens_hsa052120.76466471
57Endocytosis_Homo sapiens_hsa041440.75692423
58Bladder cancer_Homo sapiens_hsa052190.71109893
59Shigellosis_Homo sapiens_hsa051310.70450783
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.69550378
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68156365
62Salmonella infection_Homo sapiens_hsa051320.68031191
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67443031
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67276351
65HTLV-I infection_Homo sapiens_hsa051660.67080727
66Chronic myeloid leukemia_Homo sapiens_hsa052200.65228708
67MAPK signaling pathway_Homo sapiens_hsa040100.63687543
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.63404352
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61312796
70Viral carcinogenesis_Homo sapiens_hsa052030.59738414
71Type II diabetes mellitus_Homo sapiens_hsa049300.59204242
72Notch signaling pathway_Homo sapiens_hsa043300.52480530
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50857932
74mTOR signaling pathway_Homo sapiens_hsa041500.50684029
75Insulin resistance_Homo sapiens_hsa049310.49785244
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.49433544
77Amoebiasis_Homo sapiens_hsa051460.48022742
78Olfactory transduction_Homo sapiens_hsa047400.47309868
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.44548346
80Inositol phosphate metabolism_Homo sapiens_hsa005620.44144443
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43803996
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42391438
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42270005
84Lysosome_Homo sapiens_hsa041420.41790187
85Dorso-ventral axis formation_Homo sapiens_hsa043200.41123328
86HIF-1 signaling pathway_Homo sapiens_hsa040660.40328408
87Fatty acid biosynthesis_Homo sapiens_hsa000610.39578393
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35871927
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33505028
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.32061303
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29662649
92Choline metabolism in cancer_Homo sapiens_hsa052310.29636096
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28784433
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27866510
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27794165
96Renal cell carcinoma_Homo sapiens_hsa052110.26339430
97Prion diseases_Homo sapiens_hsa050200.25179035
98GnRH signaling pathway_Homo sapiens_hsa049120.22932324
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21654926
100Regulation of autophagy_Homo sapiens_hsa041400.18711365

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