TBC1D3F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.12262906
2sperm capacitation (GO:0048240)9.07539310
3DNA packaging (GO:0006323)8.86259778
4response to pheromone (GO:0019236)8.36297320
5plasma membrane fusion (GO:0045026)8.20038385
6protein targeting to Golgi (GO:0000042)8.17977919
7single strand break repair (GO:0000012)7.99292537
8establishment of protein localization to Golgi (GO:0072600)7.84843865
9spermatid development (GO:0007286)7.75174522
10microtubule depolymerization (GO:0007019)7.72923503
11retrograde transport, vesicle recycling within Golgi (GO:0000301)7.63331065
12spermatid nucleus differentiation (GO:0007289)7.50803108
13protein polyglutamylation (GO:0018095)7.22420810
14rRNA methylation (GO:0031167)7.20325516
15microtubule polymerization or depolymerization (GO:0031109)7.01849028
16sperm-egg recognition (GO:0035036)6.94327269
17centriole replication (GO:0007099)6.80046821
18multicellular organism reproduction (GO:0032504)6.55836773
19phosphatidylethanolamine biosynthetic process (GO:0006646)6.48759666
20sexual reproduction (GO:0019953)6.35001079
21calcium ion-dependent exocytosis (GO:0017156)6.30664362
22reproduction (GO:0000003)6.27187343
23spermatogenesis (GO:0007283)6.24465352
24male gamete generation (GO:0048232)6.22342116
25binding of sperm to zona pellucida (GO:0007339)6.12310685
26axonemal dynein complex assembly (GO:0070286)6.03401699
27rRNA modification (GO:0000154)6.02773673
28phosphatidylethanolamine metabolic process (GO:0046337)5.98850161
29centriole assembly (GO:0098534)5.85209303
30protein localization to Golgi apparatus (GO:0034067)5.82685466
31cell-cell recognition (GO:0009988)5.74115818
32gamete generation (GO:0007276)5.69601397
33regulation of centriole replication (GO:0046599)5.64666576
34microtubule severing (GO:0051013)5.58175081
35seminiferous tubule development (GO:0072520)5.55549410
36negative regulation of inclusion body assembly (GO:0090084)5.54484300
37RNA destabilization (GO:0050779)5.34306186
38regulation of cilium movement (GO:0003352)5.22222898
39cilium or flagellum-dependent cell motility (GO:0001539)4.89921863
40single fertilization (GO:0007338)4.88448738
41* regulation of Rab GTPase activity (GO:0032313)4.84621094
42* positive regulation of Rab GTPase activity (GO:0032851)4.84621094
43regulation of transcription involved in cell fate commitment (GO:0060850)4.84160367
44motile cilium assembly (GO:0044458)4.82046547
45cell wall macromolecule metabolic process (GO:0044036)4.73275941
46cell wall macromolecule catabolic process (GO:0016998)4.68608311
47multicellular organismal reproductive process (GO:0048609)4.56233390
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.52210291
49germ cell development (GO:0007281)4.48807402
50multicellular organismal movement (GO:0050879)4.34958419
51musculoskeletal movement (GO:0050881)4.34958419
52cellular process involved in reproduction in multicellular organism (GO:0022412)4.31088053
53cellular ketone body metabolic process (GO:0046950)4.30544703
54chromatin silencing (GO:0006342)4.27444133
55fertilization (GO:0009566)4.27344103
56nucleus organization (GO:0006997)4.24465206
57microtubule nucleation (GO:0007020)4.08562847
58epithelial cilium movement (GO:0003351)4.02212406
59glomerular visceral epithelial cell development (GO:0072015)3.92969266
60regulation of inclusion body assembly (GO:0090083)3.91392938
61ketone body metabolic process (GO:1902224)3.78135474
62glomerular epithelial cell development (GO:0072310)3.71526131
63negative regulation of Rho protein signal transduction (GO:0035024)3.59167567
64regulation of microtubule-based movement (GO:0060632)3.57681637
65coenzyme catabolic process (GO:0009109)3.56313069
66organic cation transport (GO:0015695)3.55234641
67cilium movement (GO:0003341)3.52654899
68glycerol ether metabolic process (GO:0006662)3.49772730
69Golgi to endosome transport (GO:0006895)3.48957407
70regulation of somitogenesis (GO:0014807)3.38176848
71cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.34497181
72cerebral cortex neuron differentiation (GO:0021895)3.29266686
73histone H3-K9 demethylation (GO:0033169)3.26838919
74regulation of interleukin-13 production (GO:0032656)3.25265848
75ether metabolic process (GO:0018904)3.21797420
76regulation of T-helper 2 cell differentiation (GO:0045628)3.20843879
77membrane protein intracellular domain proteolysis (GO:0031293)3.16747947
78homeostasis of number of cells within a tissue (GO:0048873)3.16265191
79cellular response to pH (GO:0071467)3.12061627
80response to acidic pH (GO:0010447)3.08757616
81intra-Golgi vesicle-mediated transport (GO:0006891)3.07751348
82nuclear pore complex assembly (GO:0051292)3.02398009
83multicellular organismal development (GO:0007275)2.99819708
84polyamine biosynthetic process (GO:0006596)2.99360762
85protein depolymerization (GO:0051261)2.98861313
86peptidyl-threonine dephosphorylation (GO:0035970)2.97579929
87regulation of phosphoprotein phosphatase activity (GO:0043666)2.92349684
88receptor recycling (GO:0001881)2.90407298
89negative regulation of gene expression, epigenetic (GO:0045814)2.87203356
90vesicle transport along microtubule (GO:0047496)2.87087811
91mitotic G1 DNA damage checkpoint (GO:0031571)2.84009532
92protein-DNA complex disassembly (GO:0032986)2.83351107
93nucleosome disassembly (GO:0006337)2.83351107
94centrosome duplication (GO:0051298)2.81264481
95mitochondrial fission (GO:0000266)2.80199383
96mast cell activation involved in immune response (GO:0002279)2.77607073
97mast cell degranulation (GO:0043303)2.77607073
98sperm motility (GO:0030317)11.8337567
99acrosome reaction (GO:0007340)11.2281696
100fusion of sperm to egg plasma membrane (GO:0007342)10.8490446

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.38808279
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.31465061
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.59347860
4POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.38541833
5TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38541833
6IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.27593014
7CBP_20019798_ChIP-Seq_JUKART_Human2.27593014
8VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.16230264
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10725073
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06817446
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01862802
12DROSHA_22980978_ChIP-Seq_HELA_Human1.95022590
13ERA_21632823_ChIP-Seq_H3396_Human1.93884763
14RAC3_21632823_ChIP-Seq_H3396_Human1.90013073
15ELF1_20517297_ChIP-Seq_JURKAT_Human1.89948091
16FUS_26573619_Chip-Seq_HEK293_Human1.86779320
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83648514
18EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.82099781
19RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.77023729
20EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.75253846
21EZH2_22144423_ChIP-Seq_EOC_Human1.74125121
22WDR5_24793694_ChIP-Seq_LNCAP_Human1.73915108
23NANOG_20526341_ChIP-Seq_ESCs_Human1.72808427
24ER_23166858_ChIP-Seq_MCF-7_Human1.72203325
25BCL6_27268052_Chip-Seq_Bcells_Human1.68452911
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65613442
27CTCF_27219007_Chip-Seq_Bcells_Human1.61371696
28MYC_19829295_ChIP-Seq_ESCs_Human1.60365588
29SMC4_20622854_ChIP-Seq_HELA_Human1.59520603
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.56020498
31TAF2_19829295_ChIP-Seq_ESCs_Human1.55460485
32* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53733947
33BCOR_27268052_Chip-Seq_Bcells_Human1.51930504
34PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.50967691
35SMAD4_21741376_ChIP-Seq_EPCs_Human1.48995691
36YY1_22570637_ChIP-Seq_MALME-3M_Human1.46065096
37OCT4_20526341_ChIP-Seq_ESCs_Human1.45886837
38HNFA_21074721_ChIP-Seq_CACO-2_Human1.45304874
39CBX2_22325352_ChIP-Seq_293T-Rex_Human1.44888240
40P68_20966046_ChIP-Seq_HELA_Human1.44798632
41RBPJ_21746931_ChIP-Seq_IB4_Human1.44446020
42CTCF_20526341_ChIP-Seq_ESCs_Human1.44241763
43E2F1_20622854_ChIP-Seq_HELA_Human1.43688297
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43201182
45PHF8_20622854_ChIP-Seq_HELA_Human1.41285089
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39611157
47ERG_20517297_ChIP-Seq_VCAP_Human1.38988690
48ETV1_20927104_ChIP-Seq_GIST48_Human1.38745649
49TP63_22573176_ChIP-Seq_HFKS_Human1.38707055
50CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.38407064
51TDRD3_21172665_ChIP-Seq_MCF-7_Human1.38087939
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37795880
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.37041454
54AR_25329375_ChIP-Seq_VCAP_Human1.36240908
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.36048333
56P300_27268052_Chip-Seq_Bcells_Human1.34129165
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33781868
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.33238643
59SMAD3_21741376_ChIP-Seq_ESCs_Human1.32787432
60TP53_18474530_ChIP-ChIP_U2OS_Human1.30059291
61NFYB_21822215_ChIP-Seq_K562_Human1.29893675
62LXR_22292898_ChIP-Seq_THP-1_Human1.26891204
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25738115
64RUNX_20019798_ChIP-Seq_JUKART_Human1.25094846
65SOX2_22085726_ChIP-Seq_NPCs_Mouse1.24144487
66* CEBPB_22108803_ChIP-Seq_LS180_Human1.24088719
67P300_19829295_ChIP-Seq_ESCs_Human1.23812016
68KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.23777176
69TBL1_22424771_ChIP-Seq_293T_Human1.23422762
70GATA3_21878914_ChIP-Seq_MCF-7_Human1.22294086
71PHF8_20622853_ChIP-Seq_HELA_Human1.21561908
72ZNF274_21170338_ChIP-Seq_K562_Hela1.21493131
73P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.20990751
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19692312
75TP63_19390658_ChIP-ChIP_HaCaT_Human1.17866990
76GATA6_21074721_ChIP-Seq_CACO-2_Human1.17698658
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16908025
78SMRT_27268052_Chip-Seq_Bcells_Human1.15452566
79TAF15_26573619_Chip-Seq_HEK293_Human1.15424454
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15250653
81AR_21572438_ChIP-Seq_LNCaP_Human1.14255312
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13785343
83P53_21459846_ChIP-Seq_SAOS-2_Human1.13112548
84PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.10792350
85NFYA_21822215_ChIP-Seq_K562_Human1.08303597
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08101102
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08057311
88RUNX2_22187159_ChIP-Seq_PCA_Human1.07756754
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07704944
90RUNX1_26923725_Chip-Seq_HPCs_Mouse1.07588885
91TCF4_18268006_ChIP-ChIP_LS174T_Human1.07546005
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06793159
93* SA1_27219007_Chip-Seq_Bcells_Human1.05383841
94SMAD4_21741376_ChIP-Seq_HESCs_Human1.04864979
95TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.03714356
96SPI1_20517297_ChIP-Seq_HL60_Human1.01188240
97NANOG_19829295_ChIP-Seq_ESCs_Human0.97439034
98SOX2_19829295_ChIP-Seq_ESCs_Human0.97439034
99GF1_26923725_Chip-Seq_HPCs_Mouse0.97262856
100KLF4_19829295_ChIP-Seq_ESCs_Human0.96794660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.93082905
2MP0003878_abnormal_ear_physiology5.93082905
3MP0005670_abnormal_white_adipose4.72029380
4MP0003698_abnormal_male_reproductive4.30546907
5MP0001348_abnormal_lacrimal_gland3.75881359
6MP0001929_abnormal_gametogenesis3.74681599
7MP0002161_abnormal_fertility/fecundity2.38877608
8MP0000678_abnormal_parathyroid_gland2.30366384
9MP0005451_abnormal_body_composition2.28501488
10MP0003646_muscle_fatigue2.15272281
11MP0005379_endocrine/exocrine_gland_phen2.05997722
12MP0002132_abnormal_respiratory_system2.03257513
13MP0003718_maternal_effect2.02432080
14MP0005410_abnormal_fertilization11.9300355
15MP0001485_abnormal_pinna_reflex1.76988541
16MP0005310_abnormal_salivary_gland1.70035176
17MP0002210_abnormal_sex_determination1.65620717
18MP0002822_catalepsy1.61728851
19MP0001486_abnormal_startle_reflex1.60274119
20MP0005423_abnormal_somatic_nervous1.51426820
21MP0003011_delayed_dark_adaptation1.47363348
22MP0002282_abnormal_trachea_morphology1.35182242
23MP0001145_abnormal_male_reproductive1.34077371
24MP0003879_abnormal_hair_cell1.33497014
25MP0004742_abnormal_vestibular_system1.33358666
26MP0002234_abnormal_pharynx_morphology1.30670862
27MP0002138_abnormal_hepatobiliary_system1.29726165
28MP0000653_abnormal_sex_gland1.28816507
29MP0002249_abnormal_larynx_morphology1.25922449
30MP0009053_abnormal_anal_canal1.19013978
31MP0004510_myositis1.17153242
32MP0005248_abnormal_Harderian_gland1.16840355
33MP0001963_abnormal_hearing_physiology1.11732047
34MP0001765_abnormal_ion_homeostasis1.10709689
35MP0004859_abnormal_synaptic_plasticity1.06415539
36MP0000534_abnormal_ureter_morphology1.03222815
37MP0008877_abnormal_DNA_methylation1.02806053
38MP0002127_abnormal_cardiovascular_syste1.00104288
39MP0002735_abnormal_chemical_nociception0.99461583
40MP0009115_abnormal_fat_cell0.97554481
41MP0005395_other_phenotype0.95172267
42MP0001968_abnormal_touch/_nociception0.94719246
43MP0000026_abnormal_inner_ear0.92764370
44MP0005666_abnormal_adipose_tissue0.88762522
45MP0005167_abnormal_blood-brain_barrier0.84982340
46MP0002229_neurodegeneration0.84545268
47MP0005551_abnormal_eye_electrophysiolog0.80496491
48MP0000955_abnormal_spinal_cord0.79384696
49MP0009697_abnormal_copulation0.73316020
50MP0002067_abnormal_sensory_capabilities0.72323001
51MP0008569_lethality_at_weaning0.72212421
52MP0005083_abnormal_biliary_tract0.69990996
53MP0005367_renal/urinary_system_phenotyp0.68302427
54MP0000516_abnormal_urinary_system0.68302427
55MP0005375_adipose_tissue_phenotype0.67944376
56MP0005253_abnormal_eye_physiology0.67159681
57MP0001905_abnormal_dopamine_level0.66946679
58MP0000681_abnormal_thyroid_gland0.63376897
59MP0004085_abnormal_heartbeat0.61833759
60MP0001666_abnormal_nutrient_absorption0.60029497
61MP0005535_abnormal_body_temperature0.59926115
62MP0002557_abnormal_social/conspecific_i0.59587222
63MP0005636_abnormal_mineral_homeostasis0.58533707
64MP0003137_abnormal_impulse_conducting0.55081992
65MP0002733_abnormal_thermal_nociception0.54977058
66MP0001501_abnormal_sleep_pattern0.52608623
67MP0001440_abnormal_grooming_behavior0.51629313
68MP0004233_abnormal_muscle_weight0.50166357
69MP0009764_decreased_sensitivity_to0.49783889
70MP0004484_altered_response_of0.49539041
71MP0002572_abnormal_emotion/affect_behav0.47893908
72MP0001984_abnormal_olfaction0.47289662
73MP0000049_abnormal_middle_ear0.47131696
74MP0000003_abnormal_adipose_tissue0.45565335
75MP0000230_abnormal_systemic_arterial0.44336653
76MP0009745_abnormal_behavioral_response0.43869782
77MP0002254_reproductive_system_inflammat0.42228408
78MP0003077_abnormal_cell_cycle0.41924466
79MP0000249_abnormal_blood_vessel0.41677098
80MP0008995_early_reproductive_senescence0.41603390
81MP0008961_abnormal_basal_metabolism0.41106069
82MP0010329_abnormal_lipoprotein_level0.41015379
83MP0004036_abnormal_muscle_relaxation0.40121687
84MP0000613_abnormal_salivary_gland0.39267707
85MP0001545_abnormal_hematopoietic_system0.38209542
86MP0005397_hematopoietic_system_phenotyp0.38209542
87MP0001879_abnormal_lymphatic_vessel0.38092251
88MP0002734_abnormal_mechanical_nocicepti0.38019435
89MP0001970_abnormal_pain_threshold0.37426476
90MP0002272_abnormal_nervous_system0.36599991
91MP0003699_abnormal_female_reproductive0.33698206
92MP0005623_abnormal_meninges_morphology0.32964010
93MP0005084_abnormal_gallbladder_morpholo0.32875932
94MP0003631_nervous_system_phenotype0.31632644
95MP0003936_abnormal_reproductive_system0.31274470
96MP0002928_abnormal_bile_duct0.30070306
97MP0005647_abnormal_sex_gland0.30017439
98MP0004782_abnormal_surfactant_physiolog0.29744984
99MP0000470_abnormal_stomach_morphology0.28448282
100MP0004084_abnormal_cardiac_muscle0.28314681

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.71979837
2Asymmetric septal hypertrophy (HP:0001670)6.28812961
3Absent/shortened dynein arms (HP:0200106)5.99577392
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.99577392
5Tubulointerstitial nephritis (HP:0001970)5.57747002
6Chronic hepatic failure (HP:0100626)5.29152405
7Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.90812447
8Resting tremor (HP:0002322)4.73157922
9Attenuation of retinal blood vessels (HP:0007843)4.64048669
10Male infertility (HP:0003251)4.48569063
11Bony spicule pigmentary retinopathy (HP:0007737)4.46014276
12Abnormal ciliary motility (HP:0012262)4.45203100
13Hyperkalemia (HP:0002153)4.42939391
14Abnormal respiratory motile cilium physiology (HP:0012261)4.41018821
15Cone-rod dystrophy (HP:0000548)4.30478224
16Nasal polyposis (HP:0100582)4.26917126
17Abnormal respiratory epithelium morphology (HP:0012253)4.12017542
18Abnormal respiratory motile cilium morphology (HP:0005938)4.12017542
19Aplasia/Hypoplasia of the earlobes (HP:0009906)4.05828526
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.99644789
21Abnormality of macular pigmentation (HP:0008002)3.97396590
22Infertility (HP:0000789)3.95406789
23Bell-shaped thorax (HP:0001591)3.88072401
24Potter facies (HP:0002009)3.74333466
25Facial shape deformation (HP:0011334)3.74333466
26Impulsivity (HP:0100710)3.66775592
27Hypoplasia of the thymus (HP:0000778)3.63663914
28Abnormality of the nasal mucosa (HP:0000433)3.47324788
29Amelogenesis imperfecta (HP:0000705)3.43525124
30Hypoalphalipoproteinemia (HP:0003233)3.38168110
31Enlarged epiphyses (HP:0010580)3.32880309
32Hypoplastic ischia (HP:0003175)3.32510106
33Abnormal rod and cone electroretinograms (HP:0008323)3.26300520
34Progressive sensorineural hearing impairment (HP:0000408)3.25341279
35Menstrual irregularities (HP:0000858)3.18624443
36Postural instability (HP:0002172)3.17640776
37Abnormality of dental color (HP:0011073)3.14464998
38Abnormal spermatogenesis (HP:0008669)3.01392221
39Abnormality of the ischium (HP:0003174)2.97555392
40Stage 5 chronic kidney disease (HP:0003774)2.94940179
41Progressive cerebellar ataxia (HP:0002073)2.94805524
42Portal hypertension (HP:0001409)2.89783037
43Abnormal urine output (HP:0012590)2.88561483
44Nephronophthisis (HP:0000090)2.86086750
45Truncal obesity (HP:0001956)2.83949175
46Tubulointerstitial abnormality (HP:0001969)2.81042112
47Abnormality of the costochondral junction (HP:0000919)2.79779760
48Renovascular hypertension (HP:0100817)2.76888841
49Insulin-resistant diabetes mellitus (HP:0000831)2.76125855
50Abnormality of the hepatic vasculature (HP:0006707)2.64647237
51Abnormal drinking behavior (HP:0030082)2.62403015
52Polydipsia (HP:0001959)2.62403015
53Azoospermia (HP:0000027)2.58594895
54Rhinitis (HP:0012384)2.54450986
55Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.54041039
56Unilateral renal agenesis (HP:0000122)2.50854483
57Abnormality of potassium homeostasis (HP:0011042)2.49826860
58Abnormality of renal excretion (HP:0011036)2.48348240
59Generalized aminoaciduria (HP:0002909)2.47111980
60Abnormality of the renal medulla (HP:0100957)2.41014846
61Double outlet right ventricle (HP:0001719)2.39346657
62Congenital malformation of the right heart (HP:0011723)2.39346657
63Ventricular tachycardia (HP:0004756)2.38446919
64Polyuria (HP:0000103)2.34842425
65Progressive hearing impairment (HP:0001730)2.31251323
66Intellectual disability, moderate (HP:0002342)2.28979972
67Abnormality of the aortic arch (HP:0012303)2.28472354
68Spastic paraparesis (HP:0002313)2.27436005
69Chronic bronchitis (HP:0004469)2.21472563
70Hyperuricemia (HP:0002149)2.19717410
71Increased purine levels (HP:0004368)2.19717410
72Renal dysplasia (HP:0000110)2.19069348
73Recurrent pneumonia (HP:0006532)2.13551857
74Hypophosphatemic rickets (HP:0004912)2.13333973
75Focal segmental glomerulosclerosis (HP:0000097)2.11564091
76Widely patent fontanelles and sutures (HP:0004492)2.11243922
77Sensory axonal neuropathy (HP:0003390)2.10673493
78Epiphyseal dysplasia (HP:0002656)2.09338672
79Bronchiectasis (HP:0002110)2.06552631
80Subcapsular cataract (HP:0000523)1.99758532
81Abnormality of the parathyroid morphology (HP:0011766)1.97325611
82Hyponatremia (HP:0002902)1.96370201
83Osteomalacia (HP:0002749)1.92378216
84Abnormality of the epiphysis of the femoral head (HP:0010574)1.91838746
85Recurrent corneal erosions (HP:0000495)1.90402302
86Tubular atrophy (HP:0000092)1.89113452
87Myokymia (HP:0002411)1.84751593
88Flattened epiphyses (HP:0003071)1.84144399
89Absent epiphyses (HP:0010577)1.83994558
90Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83994558
91Bradycardia (HP:0001662)1.82584264
92Flat capital femoral epiphysis (HP:0003370)1.79355636
93Sandal gap (HP:0001852)1.78991224
94Decreased central vision (HP:0007663)1.78636030
95Abnormality of femoral epiphyses (HP:0006499)1.77650632
96Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.77650632
97Renal Fanconi syndrome (HP:0001994)1.73323948
98Photophobia (HP:0000613)1.72870877
99Abnormality of the femoral head (HP:0003368)1.72146441
100Glomerulosclerosis (HP:0000096)1.68331733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK49.70550006
2TESK15.79758767
3DDR24.12959602
4INSRR3.99172658
5BRD43.80661917
6PLK23.60722891
7PNCK2.98093501
8STK382.67431555
9CAMK1G2.59032732
10PIK3CG2.16472998
11MAPK152.14708922
12MAP4K22.08064604
13STK38L2.04995904
14PRKD31.93499147
15PDPK11.59103358
16PDK11.58845240
17MST1R1.50140805
18NEK61.44298344
19WNK11.43393956
20CDK121.36367501
21TYRO31.30977975
22PTK2B1.23915064
23DYRK1B1.18256763
24CDK71.16869757
25CAMK1D1.15686907
26SIK20.89890700
27AKT30.89181163
28MAP3K110.88340242
29TESK20.86790652
30PRKG20.83317934
31KSR20.79086943
32LATS20.70859282
33PRKAA20.63272972
34RPS6KA20.62102602
35PRKG10.61095199
36MAP3K90.60709020
37CAMK10.56825825
38RPS6KA10.56700118
39RIPK40.56251007
40MAP2K20.53202872
41JAK30.52257982
42UHMK10.51169956
43BRAF0.48985521
44MAP3K40.47120223
45BRSK20.46084148
46MAP3K20.45613937
47TIE10.44440809
48CDK30.42809618
49ROCK10.41039825
50STK390.40791922
51BRSK10.40635416
52MAPK10.39313891
53CDK20.38930687
54GSK3B0.38047641
55SGK2230.35397516
56SGK4940.35397516
57CDK10.34250839
58TXK0.33195115
59MAP3K10.32745806
60LATS10.32116441
61WNK40.31576633
62RPS6KL10.31570543
63RPS6KC10.31570543
64CAMK40.31460286
65MARK10.29523827
66CDK40.29217524
67MAP3K80.29137070
68BLK0.28803019
69MAPK80.28475867
70SGK10.28105474
71RPS6KA60.27816199
72PRKCZ0.27376043
73BMPR1B0.27363660
74OXSR10.26733535
75MTOR0.26338337
76NTRK30.24667297
77PRKCB0.23222666
78PRKCG0.22745864
79IKBKB0.22527237
80MUSK0.22002971
81MARK20.20988857
82CHEK10.20918804
83MAPK140.19224318
84TNIK0.17541768
85MAPK110.16256799
86CHUK0.13989242
87MAPK100.13959583
88AKT10.13562006
89CDK190.12196010
90SGK20.10826378
91PKN10.08471381
92PRKAA10.08228964
93PRKACB0.08135922
94GRK60.06416321
95TNK20.05927765
96PRKACA0.05762731
97RIPK10.05013400
98KIT0.02755641
99MAPK90.02702263
100SGK30.02163337

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.81091022
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.26136959
3Olfactory transduction_Homo sapiens_hsa047404.07460045
4Glycerophospholipid metabolism_Homo sapiens_hsa005642.11753266
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08464818
6Butanoate metabolism_Homo sapiens_hsa006502.00690448
7Dorso-ventral axis formation_Homo sapiens_hsa043201.93498762
8Type I diabetes mellitus_Homo sapiens_hsa049401.81163849
9Taste transduction_Homo sapiens_hsa047421.74938137
10Graft-versus-host disease_Homo sapiens_hsa053321.74551717
11Allograft rejection_Homo sapiens_hsa053301.73328524
12Autoimmune thyroid disease_Homo sapiens_hsa053201.69306443
13Type II diabetes mellitus_Homo sapiens_hsa049301.68418819
14Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.66524929
15Antigen processing and presentation_Homo sapiens_hsa046121.62538363
16Fatty acid degradation_Homo sapiens_hsa000711.60987257
17RNA transport_Homo sapiens_hsa030131.60220601
18Phenylalanine metabolism_Homo sapiens_hsa003601.51771209
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50354657
20Fatty acid metabolism_Homo sapiens_hsa012121.42730324
21Adipocytokine signaling pathway_Homo sapiens_hsa049201.36383638
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.21905047
23Viral myocarditis_Homo sapiens_hsa054161.20284016
24Inositol phosphate metabolism_Homo sapiens_hsa005621.19804111
25Endocytosis_Homo sapiens_hsa041441.18558045
26Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.17695353
27Protein digestion and absorption_Homo sapiens_hsa049741.14389025
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13976746
29Synaptic vesicle cycle_Homo sapiens_hsa047211.13165361
30Phototransduction_Homo sapiens_hsa047441.01042358
31Influenza A_Homo sapiens_hsa051641.00684014
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95527312
33cAMP signaling pathway_Homo sapiens_hsa040240.93843458
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92539344
35Salivary secretion_Homo sapiens_hsa049700.92020678
36ABC transporters_Homo sapiens_hsa020100.91371283
37PPAR signaling pathway_Homo sapiens_hsa033200.90279390
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89644044
39Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89363738
40Calcium signaling pathway_Homo sapiens_hsa040200.86800553
41Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86290400
42Primary bile acid biosynthesis_Homo sapiens_hsa001200.86160478
43Arginine and proline metabolism_Homo sapiens_hsa003300.85442230
44Fat digestion and absorption_Homo sapiens_hsa049750.82616279
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82197192
46Cardiac muscle contraction_Homo sapiens_hsa042600.79000464
47Morphine addiction_Homo sapiens_hsa050320.75923104
48Maturity onset diabetes of the young_Homo sapiens_hsa049500.73140660
49Glycerolipid metabolism_Homo sapiens_hsa005610.72635673
50Acute myeloid leukemia_Homo sapiens_hsa052210.72084122
51Renin-angiotensin system_Homo sapiens_hsa046140.71914036
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71105140
53Oocyte meiosis_Homo sapiens_hsa041140.68588014
54Arginine biosynthesis_Homo sapiens_hsa002200.65364578
55Tyrosine metabolism_Homo sapiens_hsa003500.60407126
56VEGF signaling pathway_Homo sapiens_hsa043700.59706100
57Circadian entrainment_Homo sapiens_hsa047130.58256862
58Renin secretion_Homo sapiens_hsa049240.57787031
59Hedgehog signaling pathway_Homo sapiens_hsa043400.57694438
60Estrogen signaling pathway_Homo sapiens_hsa049150.57605790
61Nicotine addiction_Homo sapiens_hsa050330.53765754
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.53030359
63Bile secretion_Homo sapiens_hsa049760.51665707
64Glutamatergic synapse_Homo sapiens_hsa047240.50684840
65MAPK signaling pathway_Homo sapiens_hsa040100.47837481
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47458420
67Gastric acid secretion_Homo sapiens_hsa049710.47090198
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45268017
69Retinol metabolism_Homo sapiens_hsa008300.44389888
70Pancreatic secretion_Homo sapiens_hsa049720.43565568
71B cell receptor signaling pathway_Homo sapiens_hsa046620.43399042
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43039962
73Tight junction_Homo sapiens_hsa045300.39504570
74Selenocompound metabolism_Homo sapiens_hsa004500.38466576
75Herpes simplex infection_Homo sapiens_hsa051680.37222379
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36871298
77Insulin secretion_Homo sapiens_hsa049110.36648149
78Prolactin signaling pathway_Homo sapiens_hsa049170.36467787
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35629778
80Long-term potentiation_Homo sapiens_hsa047200.35254079
81Basal transcription factors_Homo sapiens_hsa030220.34245179
82Nitrogen metabolism_Homo sapiens_hsa009100.34115385
83Purine metabolism_Homo sapiens_hsa002300.34010959
84Serotonergic synapse_Homo sapiens_hsa047260.34005237
85Cholinergic synapse_Homo sapiens_hsa047250.33327576
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32278358
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.31329439
88Fanconi anemia pathway_Homo sapiens_hsa034600.30695110
89T cell receptor signaling pathway_Homo sapiens_hsa046600.29395968
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29372107
91Viral carcinogenesis_Homo sapiens_hsa052030.28265058
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24481431
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24007202
94Oxytocin signaling pathway_Homo sapiens_hsa049210.22680127
95Chemokine signaling pathway_Homo sapiens_hsa040620.22672414
96Legionellosis_Homo sapiens_hsa051340.22604608
97ECM-receptor interaction_Homo sapiens_hsa045120.22392387
98Huntingtons disease_Homo sapiens_hsa050160.21816108
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21376860
100Toxoplasmosis_Homo sapiens_hsa051450.21153904

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