TBC1D3G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.97565741
2sperm capacitation (GO:0048240)9.46877639
3chromosome condensation (GO:0030261)9.38178674
4single strand break repair (GO:0000012)9.26437287
5DNA packaging (GO:0006323)9.25193678
6spermatid nucleus differentiation (GO:0007289)8.73626795
7spermatid development (GO:0007286)7.80318283
8plasma membrane fusion (GO:0045026)7.65165727
9sexual reproduction (GO:0019953)7.39106876
10protein targeting to Golgi (GO:0000042)7.17802103
11protein polyglutamylation (GO:0018095)6.95606581
12sperm-egg recognition (GO:0035036)6.93605060
13establishment of protein localization to Golgi (GO:0072600)6.92152315
14microtubule depolymerization (GO:0007019)6.76541029
15retrograde transport, vesicle recycling within Golgi (GO:0000301)6.67369895
16rRNA methylation (GO:0031167)6.48904069
17reproduction (GO:0000003)6.48665926
18centriole replication (GO:0007099)6.47885594
19multicellular organism reproduction (GO:0032504)6.46964814
20phosphatidylethanolamine biosynthetic process (GO:0006646)6.45755898
21axonemal dynein complex assembly (GO:0070286)6.43354569
22calcium ion-dependent exocytosis (GO:0017156)6.36691456
23binding of sperm to zona pellucida (GO:0007339)6.23328408
24microtubule polymerization or depolymerization (GO:0031109)6.18901261
25spermatogenesis (GO:0007283)5.95747868
26phosphatidylethanolamine metabolic process (GO:0046337)5.94432184
27male gamete generation (GO:0048232)5.93744056
28regulation of cilium movement (GO:0003352)5.76988780
29cell-cell recognition (GO:0009988)5.69014862
30microtubule severing (GO:0051013)5.57104428
31rRNA modification (GO:0000154)5.47057538
32gamete generation (GO:0007276)5.43021363
33centriole assembly (GO:0098534)5.41794054
34negative regulation of inclusion body assembly (GO:0090084)5.37446469
35regulation of centriole replication (GO:0046599)5.34224293
36* positive regulation of Rab GTPase activity (GO:0032851)5.24376641
37* regulation of Rab GTPase activity (GO:0032313)5.24376641
38protein localization to Golgi apparatus (GO:0034067)5.20676416
39regulation of transcription involved in cell fate commitment (GO:0060850)5.13413768
40chromatin silencing (GO:0006342)5.11355788
41cilium or flagellum-dependent cell motility (GO:0001539)5.03711513
42cell wall macromolecule metabolic process (GO:0044036)4.96619825
43motile cilium assembly (GO:0044458)4.90385883
44RNA destabilization (GO:0050779)4.80318022
45cell wall macromolecule catabolic process (GO:0016998)4.67771564
46single fertilization (GO:0007338)4.58684241
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58330389
48seminiferous tubule development (GO:0072520)4.57140413
49germ cell development (GO:0007281)4.55939264
50cellular ketone body metabolic process (GO:0046950)4.53834087
51cellular process involved in reproduction in multicellular organism (GO:0022412)4.40919884
52nucleus organization (GO:0006997)4.37043829
53multicellular organismal reproductive process (GO:0048609)4.34591572
54epithelial cilium movement (GO:0003351)4.16694977
55cerebral cortex neuron differentiation (GO:0021895)4.04768361
56fertilization (GO:0009566)4.02879343
57musculoskeletal movement (GO:0050881)4.00446865
58multicellular organismal movement (GO:0050879)4.00446865
59ketone body metabolic process (GO:1902224)3.99042424
60regulation of inclusion body assembly (GO:0090083)3.94733967
61regulation of microtubule-based movement (GO:0060632)3.84979973
62organic cation transport (GO:0015695)3.74179898
63microtubule nucleation (GO:0007020)3.73630110
64cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.65415489
65Golgi to endosome transport (GO:0006895)3.58036053
66cilium movement (GO:0003341)3.57799247
67protein-DNA complex disassembly (GO:0032986)3.57533898
68nucleosome disassembly (GO:0006337)3.57533898
69coenzyme catabolic process (GO:0009109)3.55823055
70negative regulation of gene expression, epigenetic (GO:0045814)3.51949434
71peptidyl-threonine dephosphorylation (GO:0035970)3.41251352
72glycerol ether metabolic process (GO:0006662)3.39266244
73response to acidic pH (GO:0010447)3.38946414
74histone H3-K9 demethylation (GO:0033169)3.35581069
75regulation of interleukin-13 production (GO:0032656)3.34277174
76negative regulation of Rho protein signal transduction (GO:0035024)3.31190193
77regulation of T-helper 2 cell differentiation (GO:0045628)3.23677874
78polyamine biosynthetic process (GO:0006596)3.22425233
79ether metabolic process (GO:0018904)3.14028076
80homeostasis of number of cells within a tissue (GO:0048873)3.13250877
81cellular response to pH (GO:0071467)3.13157402
82male meiosis I (GO:0007141)3.09450283
83multicellular organismal development (GO:0007275)3.05020438
84receptor recycling (GO:0001881)3.03239985
85DNA conformation change (GO:0071103)2.97975968
86detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.92371528
87alanine transport (GO:0032328)2.90431805
88cranial nerve morphogenesis (GO:0021602)2.89787176
89histone exchange (GO:0043486)2.89466377
90epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85401407
91positive regulation of guanylate cyclase activity (GO:0031284)2.84730631
92centrosome duplication (GO:0051298)2.84681696
93negative regulation of histone methylation (GO:0031061)2.82593318
94positive regulation of action potential (GO:0045760)2.80068495
95regulation of phosphoprotein phosphatase activity (GO:0043666)2.79871064
96regulation of somitogenesis (GO:0014807)2.78101448
97regulation of guanylate cyclase activity (GO:0031282)2.78010338
98sperm motility (GO:0030317)11.8379056
99acrosome reaction (GO:0007340)11.5465795
100fusion of sperm to egg plasma membrane (GO:0007342)10.0549645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.31502304
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.25457043
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.13645548
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22896612
5TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20985566
6POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.20985566
7VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.15763751
8EZH2_22144423_ChIP-Seq_EOC_Human2.15580174
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14602836
10ELF1_20517297_ChIP-Seq_JURKAT_Human2.10297049
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06473697
12EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.02312793
13* CBP_20019798_ChIP-Seq_JUKART_Human2.02169870
14* IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.02169870
15* ERA_21632823_ChIP-Seq_H3396_Human1.99678632
16DROSHA_22980978_ChIP-Seq_HELA_Human1.95615339
17RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.95594530
18WDR5_24793694_ChIP-Seq_LNCAP_Human1.92841335
19RAC3_21632823_ChIP-Seq_H3396_Human1.92601123
20EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.89465311
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.85273346
22NANOG_20526341_ChIP-Seq_ESCs_Human1.83883474
23ER_23166858_ChIP-Seq_MCF-7_Human1.83008638
24FUS_26573619_Chip-Seq_HEK293_Human1.80745384
25BCL6_27268052_Chip-Seq_Bcells_Human1.80638387
26CTCF_27219007_Chip-Seq_Bcells_Human1.70181365
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.69754898
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.66600442
29AR_21572438_ChIP-Seq_LNCaP_Human1.63538711
30E2F1_20622854_ChIP-Seq_HELA_Human1.62227568
31TAF2_19829295_ChIP-Seq_ESCs_Human1.59863599
32ETV2_25802403_ChIP-Seq_MESCs_Mouse1.59216283
33CTCF_20526341_ChIP-Seq_ESCs_Human1.58303929
34* SMC4_20622854_ChIP-Seq_HELA_Human1.58048484
35MYC_19829295_ChIP-Seq_ESCs_Human1.56622215
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54763517
37OCT4_20526341_ChIP-Seq_ESCs_Human1.54674851
38* P68_20966046_ChIP-Seq_HELA_Human1.54537552
39ZNF274_21170338_ChIP-Seq_K562_Hela1.52647718
40AUTS2_25519132_ChIP-Seq_293T-REX_Human1.51589448
41* PHF8_20622854_ChIP-Seq_HELA_Human1.50330391
42YY1_22570637_ChIP-Seq_MALME-3M_Human1.49172716
43AR_25329375_ChIP-Seq_VCAP_Human1.49139177
44* BCOR_27268052_Chip-Seq_Bcells_Human1.46225013
45ERG_20517297_ChIP-Seq_VCAP_Human1.44714552
46TP63_22573176_ChIP-Seq_HFKS_Human1.44075207
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.43909011
48SMAD4_21741376_ChIP-Seq_EPCs_Human1.41549984
49TDRD3_21172665_ChIP-Seq_MCF-7_Human1.40976162
50PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.39459470
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39267933
52SMAD3_21741376_ChIP-Seq_ESCs_Human1.37474561
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36266184
54RBPJ_21746931_ChIP-Seq_IB4_Human1.35177564
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34655829
56CEBPB_22108803_ChIP-Seq_LS180_Human1.33130781
57CBX2_22325352_ChIP-Seq_293T-Rex_Human1.32056386
58* P300_27268052_Chip-Seq_Bcells_Human1.31998811
59HNFA_21074721_ChIP-Seq_CACO-2_Human1.31073221
60ETV1_20927104_ChIP-Seq_GIST48_Human1.30684445
61GATA3_21878914_ChIP-Seq_MCF-7_Human1.29915114
62SOX2_22085726_ChIP-Seq_NPCs_Mouse1.28026232
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.27482508
64LXR_22292898_ChIP-Seq_THP-1_Human1.26928697
65P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.25420253
66P53_21459846_ChIP-Seq_SAOS-2_Human1.23231147
67SA1_27219007_Chip-Seq_Bcells_Human1.23077135
68* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20693761
69P300_19829295_ChIP-Seq_ESCs_Human1.20662677
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.20483282
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20257017
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19370147
73KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.18872149
74NFYB_21822215_ChIP-Seq_K562_Human1.18863524
75SMRT_27268052_Chip-Seq_Bcells_Human1.17710139
76RUNX1_26923725_Chip-Seq_HPCs_Mouse1.17017644
77TAF15_26573619_Chip-Seq_HEK293_Human1.15367293
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14584209
79TBL1_22424771_ChIP-Seq_293T_Human1.14526518
80TP53_18474530_ChIP-ChIP_U2OS_Human1.13326676
81RUNX2_22187159_ChIP-Seq_PCA_Human1.12647740
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12261372
83PHF8_20622853_ChIP-Seq_HELA_Human1.11052134
84EZH2_27294783_Chip-Seq_ESCs_Mouse1.10393868
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08694795
86SPI1_20517297_ChIP-Seq_HL60_Human1.08520631
87ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07812569
88GATA6_21074721_ChIP-Seq_CACO-2_Human1.07349151
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.07173642
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05001113
91OCT4_19829295_ChIP-Seq_ESCs_Human1.04520028
92HOXB7_26014856_ChIP-Seq_BT474_Human1.04180004
93NFYA_21822215_ChIP-Seq_K562_Human1.02652769
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01602953
95PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00680587
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.99807669
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.99737285
98TCF4_18268006_ChIP-ChIP_LS174T_Human0.99481486
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.97654326
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97263964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology5.48255546
2MP0005377_hearing/vestibular/ear_phenot5.48255546
3MP0001348_abnormal_lacrimal_gland4.81698413
4MP0005670_abnormal_white_adipose4.52627046
5MP0003698_abnormal_male_reproductive4.25647770
6MP0001929_abnormal_gametogenesis3.66102618
7MP0000678_abnormal_parathyroid_gland2.44623238
8MP0005379_endocrine/exocrine_gland_phen2.44053965
9MP0002161_abnormal_fertility/fecundity2.38880283
10MP0002132_abnormal_respiratory_system2.07419562
11MP0003718_maternal_effect2.07111805
12MP0005410_abnormal_fertilization11.6997634
13MP0002822_catalepsy1.97435908
14MP0002210_abnormal_sex_determination1.77203777
15MP0005451_abnormal_body_composition1.75008470
16MP0003646_muscle_fatigue1.69480761
17MP0001485_abnormal_pinna_reflex1.66214436
18MP0001486_abnormal_startle_reflex1.55675606
19MP0005423_abnormal_somatic_nervous1.54833126
20MP0002282_abnormal_trachea_morphology1.44949579
21MP0004859_abnormal_synaptic_plasticity1.44790338
22MP0002249_abnormal_larynx_morphology1.38674646
23MP0002234_abnormal_pharynx_morphology1.38196676
24MP0001145_abnormal_male_reproductive1.37804805
25MP0000653_abnormal_sex_gland1.33469052
26MP0002735_abnormal_chemical_nociception1.32993447
27MP0009053_abnormal_anal_canal1.32861875
28MP0008877_abnormal_DNA_methylation1.28973823
29MP0004742_abnormal_vestibular_system1.27666777
30MP0001968_abnormal_touch/_nociception1.26633594
31MP0000534_abnormal_ureter_morphology1.14910907
32MP0005248_abnormal_Harderian_gland1.14396439
33MP0005310_abnormal_salivary_gland1.13377129
34MP0003879_abnormal_hair_cell1.12080163
35MP0003011_delayed_dark_adaptation1.10644800
36MP0002138_abnormal_hepatobiliary_system1.04361988
37MP0002127_abnormal_cardiovascular_syste1.04241815
38MP0001963_abnormal_hearing_physiology1.02316679
39MP0001765_abnormal_ion_homeostasis0.98329260
40MP0001905_abnormal_dopamine_level0.94733042
41MP0000026_abnormal_inner_ear0.93796916
42MP0002254_reproductive_system_inflammat0.91945016
43MP0005666_abnormal_adipose_tissue0.91278240
44MP0005395_other_phenotype0.90488206
45MP0000955_abnormal_spinal_cord0.86815487
46MP0002229_neurodegeneration0.85311428
47MP0000681_abnormal_thyroid_gland0.80875475
48MP0002067_abnormal_sensory_capabilities0.80453614
49MP0002733_abnormal_thermal_nociception0.79289408
50MP0009115_abnormal_fat_cell0.79029413
51MP0009745_abnormal_behavioral_response0.77434672
52MP0002557_abnormal_social/conspecific_i0.77125047
53MP0005375_adipose_tissue_phenotype0.76451821
54MP0000516_abnormal_urinary_system0.75978037
55MP0005367_renal/urinary_system_phenotyp0.75978037
56MP0008569_lethality_at_weaning0.75667291
57MP0009697_abnormal_copulation0.75405893
58MP0003880_abnormal_central_pattern0.75325823
59MP0005551_abnormal_eye_electrophysiolog0.74133170
60MP0010386_abnormal_urinary_bladder0.71785793
61MP0005535_abnormal_body_temperature0.70875086
62MP0000049_abnormal_middle_ear0.68920216
63MP0004085_abnormal_heartbeat0.68062821
64MP0004510_myositis0.65822608
65MP0005253_abnormal_eye_physiology0.65346197
66MP0005167_abnormal_blood-brain_barrier0.65332758
67MP0002572_abnormal_emotion/affect_behav0.64277509
68MP0001440_abnormal_grooming_behavior0.62810987
69MP0006292_abnormal_olfactory_placode0.61761749
70MP0000003_abnormal_adipose_tissue0.61396795
71MP0001970_abnormal_pain_threshold0.60018741
72MP0002272_abnormal_nervous_system0.57755818
73MP0005636_abnormal_mineral_homeostasis0.57523568
74MP0002734_abnormal_mechanical_nocicepti0.53444150
75MP0001666_abnormal_nutrient_absorption0.52819314
76MP0004484_altered_response_of0.51598463
77MP0003635_abnormal_synaptic_transmissio0.48965852
78MP0003119_abnormal_digestive_system0.48459382
79MP0004233_abnormal_muscle_weight0.48268143
80MP0003137_abnormal_impulse_conducting0.46742226
81MP0001879_abnormal_lymphatic_vessel0.45611790
82MP0006276_abnormal_autonomic_nervous0.43364294
83MP0008995_early_reproductive_senescence0.41991969
84MP0003699_abnormal_female_reproductive0.41495764
85MP0005084_abnormal_gallbladder_morpholo0.41145594
86MP0000613_abnormal_salivary_gland0.40857457
87MP0003077_abnormal_cell_cycle0.39998646
88MP0000470_abnormal_stomach_morphology0.39261146
89MP0001501_abnormal_sleep_pattern0.39053891
90MP0009046_muscle_twitch0.38088915
91MP0000566_synostosis0.36677942
92MP0003936_abnormal_reproductive_system0.35559357
93MP0005391_vision/eye_phenotype0.34852773
94MP0005647_abnormal_sex_gland0.34605040
95MP0002882_abnormal_neuron_morphology0.33253755
96MP0002064_seizures0.32580053
97MP0001984_abnormal_olfaction0.30530397
98MP0009764_decreased_sensitivity_to0.30276987
99MP0004036_abnormal_muscle_relaxation0.30112140
100MP0005623_abnormal_meninges_morphology0.29619890

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.53204706
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.26382583
3Absent/shortened dynein arms (HP:0200106)6.26382583
4Asymmetric septal hypertrophy (HP:0001670)6.15028970
5Tubulointerstitial nephritis (HP:0001970)4.86002533
6Bony spicule pigmentary retinopathy (HP:0007737)4.84492626
7Attenuation of retinal blood vessels (HP:0007843)4.76364873
8Abnormal ciliary motility (HP:0012262)4.69450780
9Abnormal respiratory epithelium morphology (HP:0012253)4.62193415
10Abnormal respiratory motile cilium morphology (HP:0005938)4.62193415
11Abnormal respiratory motile cilium physiology (HP:0012261)4.59718545
12Resting tremor (HP:0002322)4.46299963
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.36983633
14Chronic hepatic failure (HP:0100626)4.26116382
15Male infertility (HP:0003251)4.24555881
16Bell-shaped thorax (HP:0001591)4.24544308
17Infertility (HP:0000789)4.24056591
18Hyperkalemia (HP:0002153)4.16342679
19Potter facies (HP:0002009)4.04271749
20Facial shape deformation (HP:0011334)4.04271749
21Nasal polyposis (HP:0100582)3.96731188
22Aplasia/Hypoplasia of the earlobes (HP:0009906)3.83794166
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.82678970
24Cone-rod dystrophy (HP:0000548)3.81220680
25Impulsivity (HP:0100710)3.77482087
26Abnormality of macular pigmentation (HP:0008002)3.76448927
27Hypoplastic ischia (HP:0003175)3.48857975
28Abnormal rod and cone electroretinograms (HP:0008323)3.48775113
29Abnormal urine output (HP:0012590)3.39908315
30Hypoplasia of the thymus (HP:0000778)3.38233864
31Abnormal spermatogenesis (HP:0008669)3.28940556
32Nephronophthisis (HP:0000090)3.25460977
33Amelogenesis imperfecta (HP:0000705)3.22932788
34Abnormality of the nasal mucosa (HP:0000433)3.16069750
35Polydipsia (HP:0001959)3.11724247
36Abnormal drinking behavior (HP:0030082)3.11724247
37Abnormality of the ischium (HP:0003174)3.07721890
38Abnormality of dental color (HP:0011073)3.06497226
39Enlarged epiphyses (HP:0010580)3.05037915
40Azoospermia (HP:0000027)2.95656499
41Postural instability (HP:0002172)2.95434848
42Abnormality of renal excretion (HP:0011036)2.93455539
43Polyuria (HP:0000103)2.91717702
44Progressive cerebellar ataxia (HP:0002073)2.88397954
45Congenital malformation of the right heart (HP:0011723)2.74504799
46Double outlet right ventricle (HP:0001719)2.74504799
47Abnormality of the renal medulla (HP:0100957)2.70697709
48Abnormality of potassium homeostasis (HP:0011042)2.68882940
49Hypoalphalipoproteinemia (HP:0003233)2.68395665
50Progressive sensorineural hearing impairment (HP:0000408)2.63485472
51Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.62438001
52Rhinitis (HP:0012384)2.61905070
53Tubulointerstitial abnormality (HP:0001969)2.60813856
54Abnormality of the costochondral junction (HP:0000919)2.54285652
55Stage 5 chronic kidney disease (HP:0003774)2.52725713
56Truncal obesity (HP:0001956)2.47164187
57Renal dysplasia (HP:0000110)2.46394576
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.42781274
59Abnormality of the aortic arch (HP:0012303)2.39856668
60Generalized aminoaciduria (HP:0002909)2.36333080
61Unilateral renal agenesis (HP:0000122)2.35969869
62Tetany (HP:0001281)2.35108581
63Portal hypertension (HP:0001409)2.30556731
64Spastic paraparesis (HP:0002313)2.28614566
65Menstrual irregularities (HP:0000858)2.27346997
66Intellectual disability, moderate (HP:0002342)2.19143357
67Cerebellar dysplasia (HP:0007033)2.18299973
68Abnormality of the parathyroid morphology (HP:0011766)2.17207334
69Epiphyseal dysplasia (HP:0002656)2.16355393
70Widely patent fontanelles and sutures (HP:0004492)2.14106715
71Myokymia (HP:0002411)2.10181679
72Abnormality of the hepatic vasculature (HP:0006707)2.08963227
73Tubular atrophy (HP:0000092)2.07608909
74Occipital encephalocele (HP:0002085)2.04030896
75Hypophosphatemic rickets (HP:0004912)2.02372181
76Ventricular tachycardia (HP:0004756)2.01714185
77Bronchiectasis (HP:0002110)2.00542965
78Insulin-resistant diabetes mellitus (HP:0000831)1.99833251
79Osteomalacia (HP:0002749)1.97194029
80Sensory axonal neuropathy (HP:0003390)1.97118536
81Hyponatremia (HP:0002902)1.96781642
82Hyperuricemia (HP:0002149)1.96123851
83Increased purine levels (HP:0004368)1.96123851
84Anterior segment dysgenesis (HP:0007700)1.94063787
85Renal Fanconi syndrome (HP:0001994)1.91929971
86Hypokalemia (HP:0002900)1.90150160
87Renovascular hypertension (HP:0100817)1.86963703
88Chronic bronchitis (HP:0004469)1.86226389
89Hypoparathyroidism (HP:0000829)1.83547363
90Photophobia (HP:0000613)1.79376665
91Type II lissencephaly (HP:0007260)1.78088112
92Abnormality of the pubic bones (HP:0003172)1.76844302
93Optic nerve hypoplasia (HP:0000609)1.75802317
94Abnormality of the epiphysis of the femoral head (HP:0010574)1.72832773
95Recurrent corneal erosions (HP:0000495)1.72298923
96Short ribs (HP:0000773)1.68053095
97Abnormal ventriculo-arterial connection (HP:0011563)1.67861335
98Transposition of the great arteries (HP:0001669)1.67861335
99Abnormal connection of the cardiac segments (HP:0011545)1.67861335
100Hypochromic microcytic anemia (HP:0004840)1.67096808

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK49.13197348
2TESK16.13216563
3DDR24.15947559
4PLK23.61197647
5STK383.08451338
6PNCK3.01499459
7INSRR2.79048675
8BRD42.64828757
9CAMK1G2.50020406
10MAP4K22.21627643
11MAPK152.20727509
12STK38L2.12076834
13WNK42.10948355
14PRKD32.10850036
15STK391.91963634
16MST1R1.58803484
17PDPK11.58577331
18OXSR11.55281193
19PDK11.52162342
20PIK3CG1.43005425
21TESK21.38002288
22WNK11.37002663
23PTK2B1.30519076
24CDK71.26601029
25MAP3K91.16680077
26DYRK1B1.12746066
27CAMK1D1.12018824
28SIK21.05591346
29NEK61.05572126
30LATS20.96136549
31MAP3K110.93703275
32CDK120.92257965
33UHMK10.91792853
34PRKG20.85284815
35AKT30.76223327
36PRKG10.72182535
37RPS6KA20.70710907
38LATS10.67886383
39BRAF0.67476204
40MARK10.66282095
41STK160.65416221
42PRKAA20.64285495
43TYRO30.60218513
44RPS6KA10.60082048
45KSR20.58035563
46CAMK10.57392781
47TNIK0.45296082
48ROCK10.44556829
49CDK20.44512397
50GSK3B0.44232497
51MAP3K40.43733142
52BMPR1B0.43606906
53CDK10.40609328
54RPS6KC10.39580656
55RPS6KL10.39580656
56MAPK10.39464875
57NTRK30.39110438
58MAP3K80.38304361
59RPS6KA60.37365966
60CDK30.36864896
61CDK190.36815014
62MAP2K20.36216005
63PRKCG0.33867953
64MAP2K70.33755183
65SGK4940.33219833
66SGK2230.33219833
67SGK10.32652238
68MAPK80.32114659
69CHEK10.31859950
70ARAF0.31808989
71JAK30.31561086
72MTOR0.31556906
73MUSK0.30799193
74ADRBK20.29654050
75GRK70.28519137
76PRKCZ0.28483786
77MAPK140.27088650
78CAMK40.26667694
79MAP3K10.24501332
80PRKCB0.24234401
81PKN10.23364539
82TIE10.20168397
83BRSK10.19051080
84DYRK30.17864185
85AKT10.17162333
86PRKACB0.15072842
87MAPK110.15048700
88MAPK100.14409197
89MAP3K20.13651109
90PRKAA10.12960046
91MET0.12812858
92PRKCE0.12617373
93MARK20.11830817
94FER0.11709020
95NUAK10.11597942
96PRKACA0.10648799
97NEK20.10507631
98BRSK20.09396978
99IKBKB0.07579105
100RIPK40.07315223

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.06445888
2Fatty acid biosynthesis_Homo sapiens_hsa000615.94631177
3Olfactory transduction_Homo sapiens_hsa047404.37463965
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39451134
5Butanoate metabolism_Homo sapiens_hsa006502.34453974
6Glycerophospholipid metabolism_Homo sapiens_hsa005642.15150946
7Synaptic vesicle cycle_Homo sapiens_hsa047211.88296755
8Taste transduction_Homo sapiens_hsa047421.80768241
9Dorso-ventral axis formation_Homo sapiens_hsa043201.68238482
10RNA transport_Homo sapiens_hsa030131.67854764
11Type I diabetes mellitus_Homo sapiens_hsa049401.66889865
12Allograft rejection_Homo sapiens_hsa053301.61218668
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.58723588
14Phenylalanine metabolism_Homo sapiens_hsa003601.58462283
15Fatty acid degradation_Homo sapiens_hsa000711.56956548
16Autoimmune thyroid disease_Homo sapiens_hsa053201.56365349
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55210778
18Type II diabetes mellitus_Homo sapiens_hsa049301.47724750
19Graft-versus-host disease_Homo sapiens_hsa053321.46774158
20Antigen processing and presentation_Homo sapiens_hsa046121.41431923
21Fatty acid metabolism_Homo sapiens_hsa012121.37258339
22Cardiac muscle contraction_Homo sapiens_hsa042601.35517714
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33554957
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33025533
25Phototransduction_Homo sapiens_hsa047441.30910520
26Arginine and proline metabolism_Homo sapiens_hsa003301.27710115
27Endocytosis_Homo sapiens_hsa041441.17697328
28Nicotine addiction_Homo sapiens_hsa050331.14339245
29Protein digestion and absorption_Homo sapiens_hsa049741.13144838
30Adipocytokine signaling pathway_Homo sapiens_hsa049201.12609888
31Inositol phosphate metabolism_Homo sapiens_hsa005621.08842938
32Viral myocarditis_Homo sapiens_hsa054161.07634196
33Fat digestion and absorption_Homo sapiens_hsa049751.06094937
34Salivary secretion_Homo sapiens_hsa049701.04491270
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02705270
36Calcium signaling pathway_Homo sapiens_hsa040200.98590359
37Selenocompound metabolism_Homo sapiens_hsa004500.98408267
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97444918
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97142058
40Basal transcription factors_Homo sapiens_hsa030220.94773244
41Morphine addiction_Homo sapiens_hsa050320.94566385
42Circadian entrainment_Homo sapiens_hsa047130.93389364
43Renin-angiotensin system_Homo sapiens_hsa046140.89165882
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.86672316
45Arginine biosynthesis_Homo sapiens_hsa002200.86129534
46Glycerolipid metabolism_Homo sapiens_hsa005610.81647501
47Oocyte meiosis_Homo sapiens_hsa041140.81122920
48cAMP signaling pathway_Homo sapiens_hsa040240.80797153
49PPAR signaling pathway_Homo sapiens_hsa033200.80710892
50ABC transporters_Homo sapiens_hsa020100.79846509
51Hedgehog signaling pathway_Homo sapiens_hsa043400.79773246
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76714306
53Huntingtons disease_Homo sapiens_hsa050160.71549428
54Tyrosine metabolism_Homo sapiens_hsa003500.70603255
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70092889
56Glutamatergic synapse_Homo sapiens_hsa047240.68677371
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65309909
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65062794
59Maturity onset diabetes of the young_Homo sapiens_hsa049500.60777680
60Estrogen signaling pathway_Homo sapiens_hsa049150.60431340
61Gastric acid secretion_Homo sapiens_hsa049710.58583205
62Influenza A_Homo sapiens_hsa051640.58074891
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57864458
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57139199
65Renin secretion_Homo sapiens_hsa049240.55119413
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54903114
67Fanconi anemia pathway_Homo sapiens_hsa034600.53980261
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53857463
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52828361
70Purine metabolism_Homo sapiens_hsa002300.52199614
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51478625
72Tight junction_Homo sapiens_hsa045300.48736842
73Insulin secretion_Homo sapiens_hsa049110.47183162
74Bile secretion_Homo sapiens_hsa049760.46340314
75MAPK signaling pathway_Homo sapiens_hsa040100.46317512
76Retinol metabolism_Homo sapiens_hsa008300.44245547
77GABAergic synapse_Homo sapiens_hsa047270.41300633
78Nitrogen metabolism_Homo sapiens_hsa009100.39281443
79Acute myeloid leukemia_Homo sapiens_hsa052210.39005843
80Cholinergic synapse_Homo sapiens_hsa047250.38964728
81Pancreatic secretion_Homo sapiens_hsa049720.38086266
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.36911747
83Serotonergic synapse_Homo sapiens_hsa047260.35259229
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35253181
85VEGF signaling pathway_Homo sapiens_hsa043700.32036955
86Oxytocin signaling pathway_Homo sapiens_hsa049210.30940188
87Linoleic acid metabolism_Homo sapiens_hsa005910.29151602
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27362619
89Metabolic pathways_Homo sapiens_hsa011000.24949515
90mRNA surveillance pathway_Homo sapiens_hsa030150.23938884
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19348564
92Biosynthesis of amino acids_Homo sapiens_hsa012300.18745662
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.18443092
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16470751
95Mineral absorption_Homo sapiens_hsa049780.13923715
96Viral carcinogenesis_Homo sapiens_hsa052030.13665969
97Herpes simplex infection_Homo sapiens_hsa051680.12590383
98ECM-receptor interaction_Homo sapiens_hsa045120.12504353
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.10908627
100Thyroid hormone synthesis_Homo sapiens_hsa049180.09376709

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