TBC1D3H

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)9.86281041
2sperm motility (GO:0030317)9.05969951
3plasma membrane fusion (GO:0045026)8.05895546
4microtubule depolymerization (GO:0007019)7.37979213
5sperm-egg recognition (GO:0035036)6.83377383
6single strand break repair (GO:0000012)6.79661094
7binding of sperm to zona pellucida (GO:0007339)6.72392925
8calcium ion-dependent exocytosis (GO:0017156)6.44216022
9spermatid development (GO:0007286)6.32039646
10chromosome condensation (GO:0030261)6.20572026
11protein polyglutamylation (GO:0018095)6.01726686
12multicellular organism reproduction (GO:0032504)5.95585223
13DNA packaging (GO:0006323)5.83299295
14cellular ketone body metabolic process (GO:0046950)5.78795455
15positive regulation of action potential (GO:0045760)5.78100079
16cell-cell recognition (GO:0009988)5.60408872
17microtubule polymerization or depolymerization (GO:0031109)5.58621503
18sperm capacitation (GO:0048240)5.52302291
19spermatogenesis (GO:0007283)5.39287078
20microtubule severing (GO:0051013)5.37441054
21male gamete generation (GO:0048232)5.37323665
22reproduction (GO:0000003)5.24048138
23ketone body metabolic process (GO:1902224)5.05061906
24negative regulation of inclusion body assembly (GO:0090084)5.03321915
25protein targeting to Golgi (GO:0000042)5.02310304
26establishment of protein localization to Golgi (GO:0072600)4.99107587
27gamete generation (GO:0007276)4.97212101
28axonemal dynein complex assembly (GO:0070286)4.90986284
29coenzyme catabolic process (GO:0009109)4.70955597
30spermatid nucleus differentiation (GO:0007289)4.62868756
31retrograde transport, vesicle recycling within Golgi (GO:0000301)4.58667199
32rRNA methylation (GO:0031167)4.56847311
33regulation of cilium movement (GO:0003352)4.30278838
34motile cilium assembly (GO:0044458)4.27238570
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.22121141
36seminiferous tubule development (GO:0072520)4.11736001
37protein localization to Golgi apparatus (GO:0034067)4.08831684
38sexual reproduction (GO:0019953)4.08690454
39male meiosis I (GO:0007141)4.07375141
40* regulation of Rab GTPase activity (GO:0032313)4.05754931
41* positive regulation of Rab GTPase activity (GO:0032851)4.05754931
42epithelial cilium movement (GO:0003351)4.04509891
43cerebral cortex neuron differentiation (GO:0021895)4.02088369
44piRNA metabolic process (GO:0034587)4.00264528
45rRNA modification (GO:0000154)3.96702586
46single fertilization (GO:0007338)3.96124608
47multicellular organismal reproductive process (GO:0048609)3.91745093
48cell differentiation involved in metanephros development (GO:0072202)3.85690723
49synapsis (GO:0007129)3.82748631
50negative regulation of heart rate (GO:0010459)3.79404546
51phosphatidylethanolamine biosynthetic process (GO:0006646)3.73648254
52detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.71768023
53centriole replication (GO:0007099)3.71352483
54germ cell development (GO:0007281)3.59267839
55regulation of inclusion body assembly (GO:0090083)3.54420976
56DNA methylation involved in gamete generation (GO:0043046)3.51579494
57male meiosis (GO:0007140)3.50830375
58cell wall macromolecule catabolic process (GO:0016998)3.49582495
59NAD biosynthetic process (GO:0009435)3.46869688
60fertilization (GO:0009566)3.45943061
61glycerol ether metabolic process (GO:0006662)3.41715687
62phosphatidylethanolamine metabolic process (GO:0046337)3.33867347
63epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.32951962
64cilium or flagellum-dependent cell motility (GO:0001539)3.32247059
65cilium movement (GO:0003341)3.31212223
66regulation of action potential (GO:0098900)3.30943577
67cellular process involved in reproduction in multicellular organism (GO:0022412)3.28821433
68ether metabolic process (GO:0018904)3.20971012
69positive regulation of gastrulation (GO:2000543)3.15237476
70glomerular visceral epithelial cell development (GO:0072015)3.14377210
71peptidyl-threonine dephosphorylation (GO:0035970)3.14253514
72regulation of microtubule-based movement (GO:0060632)3.14194980
73mesenchymal cell differentiation involved in renal system development (GO:2001012)3.11377176
74mesenchymal cell differentiation involved in kidney development (GO:0072161)3.11377176
75pattern specification involved in kidney development (GO:0061004)3.10085720
76regulation of centriole replication (GO:0046599)3.06704941
77positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06170524
78centriole assembly (GO:0098534)3.04675562
79RNA destabilization (GO:0050779)3.04642931
80cofactor catabolic process (GO:0051187)3.04591706
81cell recognition (GO:0008037)3.03783137
82histone H3-K9 demethylation (GO:0033169)3.00671933
83negative regulation of Rho protein signal transduction (GO:0035024)3.00466671
84axoneme assembly (GO:0035082)2.98344373
85glomerular epithelial cell development (GO:0072310)2.96278569
86nonmotile primary cilium assembly (GO:0035058)2.94638105
87meiosis I (GO:0007127)2.93830005
88membrane protein intracellular domain proteolysis (GO:0031293)2.93036615
89behavioral response to nicotine (GO:0035095)2.90009211
90alanine transport (GO:0032328)2.85883571
91negative regulation of gene silencing (GO:0060969)2.84843203
92cell wall macromolecule metabolic process (GO:0044036)2.83684240
93brain morphogenesis (GO:0048854)2.83676294
94cellular response to pH (GO:0071467)2.82866232
95metanephric tubule development (GO:0072170)2.82343127
96metanephric nephron tubule development (GO:0072234)2.82343127
97tachykinin receptor signaling pathway (GO:0007217)2.79882236
98regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.76677887
99fusion of sperm to egg plasma membrane (GO:0007342)10.4577493
100acrosome reaction (GO:0007340)10.3522547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.70745511
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.05137387
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.02003077
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.72314189
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.58438868
6EZH2_22144423_ChIP-Seq_EOC_Human2.57170069
7ZNF274_21170338_ChIP-Seq_K562_Hela2.47531745
8FUS_26573619_Chip-Seq_HEK293_Human2.41507548
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.23049883
10EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.12383580
11TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11222951
12POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.11222951
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07191939
14CBP_20019798_ChIP-Seq_JUKART_Human2.06818342
15IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.06818342
16UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.96764016
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94268468
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93999912
19ERA_21632823_ChIP-Seq_H3396_Human1.93765070
20RAC3_21632823_ChIP-Seq_H3396_Human1.92325370
21VDR_22108803_ChIP-Seq_LS180_Human1.91232676
22MYC_19829295_ChIP-Seq_ESCs_Human1.80556151
23TAF15_26573619_Chip-Seq_HEK293_Human1.69825316
24EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.67994733
25ER_23166858_ChIP-Seq_MCF-7_Human1.65874079
26ETV2_25802403_ChIP-Seq_MESCs_Mouse1.63135692
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62987491
28ELF1_20517297_ChIP-Seq_JURKAT_Human1.62129644
29SMAD4_21741376_ChIP-Seq_EPCs_Human1.61055807
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.58824424
31REST_21632747_ChIP-Seq_MESCs_Mouse1.58822534
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58095934
33TAF2_19829295_ChIP-Seq_ESCs_Human1.55159495
34EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.54362224
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.51267314
36AR_25329375_ChIP-Seq_VCAP_Human1.49237365
37CTCF_27219007_Chip-Seq_Bcells_Human1.48072417
38NANOG_20526341_ChIP-Seq_ESCs_Human1.47223930
39DROSHA_22980978_ChIP-Seq_HELA_Human1.44465141
40E2F1_20622854_ChIP-Seq_HELA_Human1.43833307
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.43541575
42P300_19829295_ChIP-Seq_ESCs_Human1.42116563
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41945270
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39715812
45GATA3_21878914_ChIP-Seq_MCF-7_Human1.39078092
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.39065458
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38069462
48CTCF_20526341_ChIP-Seq_ESCs_Human1.36748889
49TP53_18474530_ChIP-ChIP_U2OS_Human1.35447851
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34413452
51PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.31258307
52TDRD3_21172665_ChIP-Seq_MCF-7_Human1.28933256
53YY1_22570637_ChIP-Seq_MALME-3M_Human1.28330928
54WDR5_24793694_ChIP-Seq_LNCAP_Human1.27622289
55BCL6_27268052_Chip-Seq_Bcells_Human1.27227044
56P53_21459846_ChIP-Seq_SAOS-2_Human1.22348048
57RUNX2_22187159_ChIP-Seq_PCA_Human1.21863611
58OCT4_20526341_ChIP-Seq_ESCs_Human1.21368842
59FOXH1_21741376_ChIP-Seq_EPCs_Human1.20513195
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19902057
61RNF2_27304074_Chip-Seq_NSC_Mouse1.19737310
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.19474404
63SMAD3_21741376_ChIP-Seq_ESCs_Human1.18994584
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.18975073
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18177350
66* AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16919646
67TP63_19390658_ChIP-ChIP_HaCaT_Human1.16868552
68PHF8_20622854_ChIP-Seq_HELA_Human1.16235102
69* HOXB7_26014856_ChIP-Seq_BT474_Human1.16112210
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.14495376
71VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14244733
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11825446
73E2F1_17053090_ChIP-ChIP_MCF-7_Human1.09964596
74ETV1_20927104_ChIP-Seq_GIST48_Human1.09543642
75CBX2_22325352_ChIP-Seq_293T-Rex_Human1.08748152
76HNFA_21074721_ChIP-Seq_CACO-2_Human1.08597000
77P68_20966046_ChIP-Seq_HELA_Human1.05992502
78JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05786690
79RBPJ_21746931_ChIP-Seq_IB4_Human1.04140532
80NFYB_21822215_ChIP-Seq_K562_Human1.03610375
81* NCOR_22424771_ChIP-Seq_293T_Human1.03476743
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03231736
83TP63_22573176_ChIP-Seq_HFKS_Human1.01922700
84SMAD4_21799915_ChIP-Seq_A2780_Human1.01872403
85EED_16625203_ChIP-ChIP_MESCs_Mouse1.01692121
86ERG_20517297_ChIP-Seq_VCAP_Human1.00876072
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.00289248
88SA1_27219007_Chip-Seq_Bcells_Human1.00054063
89SMAD4_21741376_ChIP-Seq_HESCs_Human0.99859087
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99457068
91SOX2_19829295_ChIP-Seq_ESCs_Human0.98998216
92NANOG_19829295_ChIP-Seq_ESCs_Human0.98998216
93* SOX2_21211035_ChIP-Seq_LN229_Human0.98258605
94SMC4_20622854_ChIP-Seq_HELA_Human0.97984794
95TBL1_22424771_ChIP-Seq_293T_Human0.97924629
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97892298
97JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97632898
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97374763
99FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96982297
100FOXA1_25329375_ChIP-Seq_VCAP_Human0.96982297

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.67658832
2MP0003878_abnormal_ear_physiology4.12337598
3MP0005377_hearing/vestibular/ear_phenot4.12337598
4MP0002254_reproductive_system_inflammat3.36925908
5MP0001348_abnormal_lacrimal_gland3.28682433
6MP0010386_abnormal_urinary_bladder3.12560633
7MP0003698_abnormal_male_reproductive3.08341749
8MP0008877_abnormal_DNA_methylation2.94652211
9MP0003787_abnormal_imprinting2.61087845
10MP0001929_abnormal_gametogenesis2.52714880
11MP0003011_delayed_dark_adaptation2.39813717
12MP0001968_abnormal_touch/_nociception2.32821310
13MP0003880_abnormal_central_pattern2.24269585
14MP0004859_abnormal_synaptic_plasticity2.09423938
15MP0006276_abnormal_autonomic_nervous2.01350403
16MP0001486_abnormal_startle_reflex1.81994228
17MP0005423_abnormal_somatic_nervous1.75861217
18MP0002653_abnormal_ependyma_morphology1.74578219
19MP0005670_abnormal_white_adipose1.73023161
20MP0002161_abnormal_fertility/fecundity1.71508829
21MP0005310_abnormal_salivary_gland1.67971913
22MP0004742_abnormal_vestibular_system1.66420286
23MP0002735_abnormal_chemical_nociception1.66058642
24MP0002733_abnormal_thermal_nociception1.63788293
25MP0003122_maternal_imprinting1.63054196
26MP0003121_genomic_imprinting1.62356694
27MP0003718_maternal_effect1.61498557
28MP0002210_abnormal_sex_determination1.55372346
29MP0001485_abnormal_pinna_reflex1.55209162
30MP0008995_early_reproductive_senescence1.47700986
31MP0002272_abnormal_nervous_system1.47297135
32MP0001970_abnormal_pain_threshold1.46470465
33MP0004510_myositis1.44913098
34MP0002234_abnormal_pharynx_morphology1.44430706
35MP0003879_abnormal_hair_cell1.40976731
36MP0006292_abnormal_olfactory_placode1.40915332
37MP0002736_abnormal_nociception_after1.38590041
38MP0003123_paternal_imprinting1.36279576
39MP0000678_abnormal_parathyroid_gland1.36009012
40MP0002876_abnormal_thyroid_physiology1.34058683
41MP0009046_muscle_twitch1.27042921
42MP0002138_abnormal_hepatobiliary_system1.26380930
43MP0003635_abnormal_synaptic_transmissio1.25320741
44MP0001145_abnormal_male_reproductive1.25242557
45MP0001984_abnormal_olfaction1.24953606
46MP0000653_abnormal_sex_gland1.23975912
47MP0009745_abnormal_behavioral_response1.21897425
48MP0005551_abnormal_eye_electrophysiolog1.16540714
49MP0002067_abnormal_sensory_capabilities1.13065156
50MP0003136_yellow_coat_color1.11630394
51MP0002572_abnormal_emotion/affect_behav1.08290241
52MP0002229_neurodegeneration1.07146136
53MP0001765_abnormal_ion_homeostasis1.06789377
54MP0001963_abnormal_hearing_physiology1.06731545
55MP0000427_abnormal_hair_cycle1.06704544
56MP0005636_abnormal_mineral_homeostasis1.06684731
57MP0000026_abnormal_inner_ear1.05217309
58MP0003283_abnormal_digestive_organ1.01871874
59MP0002132_abnormal_respiratory_system1.00949535
60MP0000955_abnormal_spinal_cord0.99824131
61MP0005167_abnormal_blood-brain_barrier0.99816988
62MP0002557_abnormal_social/conspecific_i0.99804135
63MP0005253_abnormal_eye_physiology0.98914650
64MP0002734_abnormal_mechanical_nocicepti0.98563558
65MP0003646_muscle_fatigue0.96691025
66MP0002064_seizures0.96176604
67MP0001501_abnormal_sleep_pattern0.94834199
68MP0001293_anophthalmia0.91843507
69MP0000778_abnormal_nervous_system0.90949953
70MP0008872_abnormal_physiological_respon0.89758976
71MP0002063_abnormal_learning/memory/cond0.87689372
72MP0004142_abnormal_muscle_tone0.87623211
73MP0001905_abnormal_dopamine_level0.86672718
74MP0001440_abnormal_grooming_behavior0.86171771
75MP0005379_endocrine/exocrine_gland_phen0.86052543
76MP0002184_abnormal_innervation0.85795160
77MP0000049_abnormal_middle_ear0.84309038
78MP0008058_abnormal_DNA_repair0.83904856
79MP0000230_abnormal_systemic_arterial0.82538510
80MP0004085_abnormal_heartbeat0.80078772
81MP0002882_abnormal_neuron_morphology0.77088792
82MP0004133_heterotaxia0.76027300
83MP0005084_abnormal_gallbladder_morpholo0.75879563
84MP0000516_abnormal_urinary_system0.75254962
85MP0005367_renal/urinary_system_phenotyp0.75254962
86MP0009697_abnormal_copulation0.75154003
87MP0005647_abnormal_sex_gland0.73923355
88MP0000647_abnormal_sebaceous_gland0.73539466
89MP0003137_abnormal_impulse_conducting0.73013248
90MP0003329_amyloid_beta_deposits0.71841937
91MP0008569_lethality_at_weaning0.71434947
92MP0002282_abnormal_trachea_morphology0.67791398
93MP0002752_abnormal_somatic_nervous0.67065006
94MP0002127_abnormal_cardiovascular_syste0.65979049
95MP0008789_abnormal_olfactory_epithelium0.61331062
96MP0003172_abnormal_lysosome_physiology0.61050963
97MP0003119_abnormal_digestive_system0.59217752
98MP0000470_abnormal_stomach_morphology0.58808163
99MP0005646_abnormal_pituitary_gland0.58253369
100MP0004270_analgesia0.58070389

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.77656843
2Polydipsia (HP:0001959)4.60913066
3Abnormal drinking behavior (HP:0030082)4.60913066
4Increased circulating renin level (HP:0000848)4.43233576
5Bony spicule pigmentary retinopathy (HP:0007737)4.13828820
6Absent/shortened dynein arms (HP:0200106)4.01571936
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.01571936
8Tetany (HP:0001281)3.92319321
9Tubulointerstitial nephritis (HP:0001970)3.90320153
10Abnormal rod and cone electroretinograms (HP:0008323)3.78025908
11Polyuria (HP:0000103)3.72734450
12Hypoplastic ischia (HP:0003175)3.68925913
13Attenuation of retinal blood vessels (HP:0007843)3.62387799
14Bell-shaped thorax (HP:0001591)3.59336762
15Nephronophthisis (HP:0000090)3.54681354
16Abnormal urine output (HP:0012590)3.48392611
17Abnormality of dental color (HP:0011073)3.33426851
18Enlarged epiphyses (HP:0010580)3.32102366
19Cone-rod dystrophy (HP:0000548)3.28215092
20Amelogenesis imperfecta (HP:0000705)3.25991564
21Azoospermia (HP:0000027)3.25207288
22Myokymia (HP:0002411)3.04865133
23Abnormality of the ischium (HP:0003174)3.04656301
24Bilateral sensorineural hearing impairment (HP:0008619)3.03922108
25Asymmetric septal hypertrophy (HP:0001670)3.00797708
26Abnormality of renal excretion (HP:0011036)3.00015428
27Abnormality of the renal medulla (HP:0100957)2.93684743
28Abnormal respiratory epithelium morphology (HP:0012253)2.92576663
29Abnormal respiratory motile cilium morphology (HP:0005938)2.92576663
30Chronic hepatic failure (HP:0100626)2.90058485
31Hypokalemic alkalosis (HP:0001949)2.87066284
32Infertility (HP:0000789)2.83359298
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.79634843
34Double outlet right ventricle (HP:0001719)2.75486288
35Congenital malformation of the right heart (HP:0011723)2.75486288
36Abnormal respiratory motile cilium physiology (HP:0012261)2.67322342
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.66193930
38Abnormal ciliary motility (HP:0012262)2.63421097
39Hypoplasia of the thymus (HP:0000778)2.62385674
40Abnormal spermatogenesis (HP:0008669)2.61446112
41Abnormality of magnesium homeostasis (HP:0004921)2.55514694
42Hypomagnesemia (HP:0002917)2.53595220
43Abnormality of macular pigmentation (HP:0008002)2.53425063
44Aplasia/Hypoplasia of the earlobes (HP:0009906)2.51103185
45Stage 5 chronic kidney disease (HP:0003774)2.45987703
46Renal Fanconi syndrome (HP:0001994)2.33496164
47Osteomalacia (HP:0002749)2.32377793
48Cerebellar dysplasia (HP:0007033)2.30717197
49Hypokalemia (HP:0002900)2.26615543
50Polyphagia (HP:0002591)2.26421696
51Progressive sensorineural hearing impairment (HP:0000408)2.22259095
52Pancreatic fibrosis (HP:0100732)2.19179326
53Abnormality of the epiphysis of the femoral head (HP:0010574)2.17673842
54Flattened epiphyses (HP:0003071)2.16261794
55Generalized aminoaciduria (HP:0002909)2.15587069
56Abnormality of the parathyroid morphology (HP:0011766)2.15024437
57Muscle fiber atrophy (HP:0100295)2.14605262
58Type II lissencephaly (HP:0007260)2.13676079
59Abnormality of the aortic arch (HP:0012303)2.11376900
60Resting tremor (HP:0002322)2.11020531
61Impulsivity (HP:0100710)2.07402178
62Abnormality of renin-angiotensin system (HP:0000847)2.07178565
63Abnormality of potassium homeostasis (HP:0011042)2.05600198
64Type 2 muscle fiber atrophy (HP:0003554)2.05542543
65Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.04420619
66Absent epiphyses (HP:0010577)2.04420619
67Tubulointerstitial abnormality (HP:0001969)2.03728368
68Decreased central vision (HP:0007663)2.02261856
69Menstrual irregularities (HP:0000858)2.00325958
70Abnormality of femoral epiphyses (HP:0006499)1.97086673
71Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.97086673
72Pancreatic cysts (HP:0001737)1.96605090
73Abnormality of midbrain morphology (HP:0002418)1.95853896
74Molar tooth sign on MRI (HP:0002419)1.95853896
75Abnormality of the femoral head (HP:0003368)1.95175439
76Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93471730
77Congenital stationary night blindness (HP:0007642)1.93291667
78Mixed hearing impairment (HP:0000410)1.91505531
79Impaired vibration sensation in the lower limbs (HP:0002166)1.90599779
80Glycosuria (HP:0003076)1.90105765
81Abnormality of urine glucose concentration (HP:0011016)1.90105765
82Failure to thrive in infancy (HP:0001531)1.89993819
83Facial shape deformation (HP:0011334)1.89322517
84Potter facies (HP:0002009)1.89322517
85Photophobia (HP:0000613)1.88610816
86Poor suck (HP:0002033)1.87612892
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.86508111
88Epiphyseal dysplasia (HP:0002656)1.84944693
89Hypoparathyroidism (HP:0000829)1.83045526
90Hypophosphatemic rickets (HP:0004912)1.80554382
91Esotropia (HP:0000565)1.78725262
92Optic nerve hypoplasia (HP:0000609)1.75017975
93Truncal obesity (HP:0001956)1.73820105
94Focal motor seizures (HP:0011153)1.73548934
95Type I diabetes mellitus (HP:0100651)1.73383987
96True hermaphroditism (HP:0010459)1.73349840
97Paralysis (HP:0003470)1.71531318
98Sclerocornea (HP:0000647)1.71087030
99Male infertility (HP:0003251)1.70688899
100Anterior segment dysgenesis (HP:0007700)1.70388366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK46.21772754
2STK395.26762606
3OXSR14.37598588
4INSRR4.36398653
5PLK44.29587661
6MAP4K24.07627673
7DDR24.06572334
8STK164.02653641
9TESK13.51980285
10PLK22.36530786
11BCKDK1.53146366
12PRKD31.46880205
13MAP2K71.46119702
14CAMK1G1.41408698
15MAP3K41.35957904
16BRD41.34422345
17MAP3K91.34411410
18TNIK1.34026262
19CASK1.31416765
20WNK11.26914833
21ADRBK21.19844593
22PINK11.19161703
23PNCK1.18860255
24MARK11.16358218
25STK381.15147989
26STK38L1.09988659
27CAMK1D1.04499274
28GRK70.95999094
29PTK2B0.94472577
30MAP3K110.93619624
31DYRK30.91753436
32CAMK10.89580095
33NTRK30.88474065
34PRKG20.86623196
35UHMK10.84613118
36MAPK150.82625509
37TLK10.79729724
38ZAK0.79419481
39SIK20.78071779
40DAPK20.70089465
41PBK0.67032132
42PRKCG0.66746751
43GRK10.65153702
44ACVR1B0.60399711
45BMPR1B0.56562634
46RPS6KA20.56176806
47PIK3CG0.56073383
48DYRK1B0.53331871
49PDK10.52155766
50CAMK40.51154873
51PIM20.50546948
52BRAF0.48284890
53WNK30.46833111
54PKN10.45995525
55MARK20.44545332
56TNK20.42563128
57DYRK20.42307267
58PRKCE0.41866175
59AKT30.40226887
60FLT30.38716372
61PRKAA20.38477639
62ABL20.37871966
63MUSK0.37610951
64PRKCZ0.36720189
65PRKG10.36593184
66TRIM280.36303671
67CDK190.35548429
68TIE10.35282375
69ROCK10.33626307
70PDPK10.30957708
71CDK30.30934588
72MAPK130.29796622
73MARK30.29403114
74NTRK20.29147349
75CAMKK20.28953034
76ARAF0.28425308
77PRKAA10.27803507
78RPS6KA60.27658865
79RPS6KA10.27194918
80GRK50.25738030
81CDK70.25389110
82RPS6KA40.24603463
83FRK0.23853545
84CDK50.22374389
85RPS6KL10.21941332
86RPS6KC10.21941332
87PRKCH0.21647909
88NUAK10.21433431
89MAPK10.21131238
90PRKACA0.21118749
91MINK10.20388941
92SGK2230.20240457
93SGK4940.20240457
94PAK30.20023843
95CAMK2A0.18698964
96GSK3B0.18007296
97CHUK0.17652921
98PLK10.17532813
99MAPK140.16665602
100CDK20.16085326

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.98578508
2Olfactory transduction_Homo sapiens_hsa047404.06305020
3Butanoate metabolism_Homo sapiens_hsa006502.92612406
4Synaptic vesicle cycle_Homo sapiens_hsa047212.64626149
5Collecting duct acid secretion_Homo sapiens_hsa049662.54407905
6Nicotine addiction_Homo sapiens_hsa050332.44298438
7Fatty acid biosynthesis_Homo sapiens_hsa000612.26417924
8Taste transduction_Homo sapiens_hsa047422.09657689
9Phenylalanine metabolism_Homo sapiens_hsa003601.67292067
10Cardiac muscle contraction_Homo sapiens_hsa042601.65202586
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64585886
12Basal transcription factors_Homo sapiens_hsa030221.59252100
13RNA transport_Homo sapiens_hsa030131.55452770
14Arginine and proline metabolism_Homo sapiens_hsa003301.51967430
15Phototransduction_Homo sapiens_hsa047441.50012904
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42219025
17Allograft rejection_Homo sapiens_hsa053301.35150788
18Oxidative phosphorylation_Homo sapiens_hsa001901.33776890
19Autoimmune thyroid disease_Homo sapiens_hsa053201.26226037
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24872034
21Glutamatergic synapse_Homo sapiens_hsa047241.23787261
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22898221
23Sulfur relay system_Homo sapiens_hsa041221.20084700
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19233705
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16665786
26Morphine addiction_Homo sapiens_hsa050321.15904166
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06916777
28Huntingtons disease_Homo sapiens_hsa050161.06357350
29Homologous recombination_Homo sapiens_hsa034401.03167257
30Graft-versus-host disease_Homo sapiens_hsa053321.01350373
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01343377
32Glycerophospholipid metabolism_Homo sapiens_hsa005640.98756182
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98738219
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97188813
35Fanconi anemia pathway_Homo sapiens_hsa034600.96806644
36Primary bile acid biosynthesis_Homo sapiens_hsa001200.96250321
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95994356
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95388495
39Salivary secretion_Homo sapiens_hsa049700.94840512
40Parkinsons disease_Homo sapiens_hsa050120.94696833
41Linoleic acid metabolism_Homo sapiens_hsa005910.92965167
42Circadian entrainment_Homo sapiens_hsa047130.92478979
43Fat digestion and absorption_Homo sapiens_hsa049750.89389290
44GABAergic synapse_Homo sapiens_hsa047270.89000858
45Fatty acid degradation_Homo sapiens_hsa000710.88975836
46Antigen processing and presentation_Homo sapiens_hsa046120.87736062
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87319490
48Type I diabetes mellitus_Homo sapiens_hsa049400.85299701
49Protein digestion and absorption_Homo sapiens_hsa049740.78365930
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78054382
51Serotonergic synapse_Homo sapiens_hsa047260.76410090
52beta-Alanine metabolism_Homo sapiens_hsa004100.75303565
53Propanoate metabolism_Homo sapiens_hsa006400.74930809
54Endocytosis_Homo sapiens_hsa041440.74343108
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71340406
56mRNA surveillance pathway_Homo sapiens_hsa030150.71273466
57Nucleotide excision repair_Homo sapiens_hsa034200.69483798
58Insulin secretion_Homo sapiens_hsa049110.69066882
59Calcium signaling pathway_Homo sapiens_hsa040200.65027129
60RNA degradation_Homo sapiens_hsa030180.63411743
61Long-term depression_Homo sapiens_hsa047300.62739090
62Base excision repair_Homo sapiens_hsa034100.62712990
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61155688
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60094836
65Notch signaling pathway_Homo sapiens_hsa043300.59585909
66Nitrogen metabolism_Homo sapiens_hsa009100.59498664
67Biosynthesis of amino acids_Homo sapiens_hsa012300.59153473
68Hedgehog signaling pathway_Homo sapiens_hsa043400.58837894
69Arginine biosynthesis_Homo sapiens_hsa002200.57951836
70Type II diabetes mellitus_Homo sapiens_hsa049300.57230902
71Tyrosine metabolism_Homo sapiens_hsa003500.55345883
72Vibrio cholerae infection_Homo sapiens_hsa051100.53764278
73Dorso-ventral axis formation_Homo sapiens_hsa043200.53610874
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52121607
75Retinol metabolism_Homo sapiens_hsa008300.51987437
76Lysosome_Homo sapiens_hsa041420.51770858
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.50052575
78Arachidonic acid metabolism_Homo sapiens_hsa005900.49681354
79Viral myocarditis_Homo sapiens_hsa054160.47499665
80Metabolic pathways_Homo sapiens_hsa011000.46763337
81Phagosome_Homo sapiens_hsa041450.46646097
82Fatty acid metabolism_Homo sapiens_hsa012120.45280540
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45079263
84cAMP signaling pathway_Homo sapiens_hsa040240.44186365
85Cholinergic synapse_Homo sapiens_hsa047250.43840748
86Pancreatic secretion_Homo sapiens_hsa049720.43361920
87MAPK signaling pathway_Homo sapiens_hsa040100.43307393
88Other glycan degradation_Homo sapiens_hsa005110.42930296
89Glycerolipid metabolism_Homo sapiens_hsa005610.40287459
90Ether lipid metabolism_Homo sapiens_hsa005650.39831124
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37773242
92Renin-angiotensin system_Homo sapiens_hsa046140.37435444
93Alzheimers disease_Homo sapiens_hsa050100.37364781
94Peroxisome_Homo sapiens_hsa041460.35478758
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35459992
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34662203
97Chemical carcinogenesis_Homo sapiens_hsa052040.34322387
98Inositol phosphate metabolism_Homo sapiens_hsa005620.33484678
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.33027134
100Sphingolipid metabolism_Homo sapiens_hsa006000.31065167

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