TBC1D3K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)7.93802050
2sperm capacitation (GO:0048240)6.17027519
3sperm motility (GO:0030317)6.15025521
4acrosome reaction (GO:0007340)6.01394130
5plasma membrane fusion (GO:0045026)5.77568866
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.63138268
7phosphatidylethanolamine biosynthetic process (GO:0006646)4.84708895
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.67301585
9negative regulation of cell killing (GO:0031342)4.67301585
10positive regulation of Rab GTPase activity (GO:0032851)4.61559045
11regulation of Rab GTPase activity (GO:0032313)4.61559045
12regulation of T-helper 2 cell differentiation (GO:0045628)4.50628922
13chromosome condensation (GO:0030261)4.36354745
14phosphatidylethanolamine metabolic process (GO:0046337)4.36128752
15DNA packaging (GO:0006323)4.12554547
16protein targeting to Golgi (GO:0000042)4.08423523
17multicellular organism reproduction (GO:0032504)4.08292898
18microtubule depolymerization (GO:0007019)3.87673682
19spermatid nucleus differentiation (GO:0007289)3.83525879
20reproduction (GO:0000003)3.83387150
21retrograde transport, vesicle recycling within Golgi (GO:0000301)3.82099438
22establishment of protein localization to Golgi (GO:0072600)3.80396498
23sexual reproduction (GO:0019953)3.75359432
24spermatid development (GO:0007286)3.68567572
25negative regulation of inclusion body assembly (GO:0090084)3.63152997
26sperm-egg recognition (GO:0035036)3.58693486
27macrophage activation involved in immune response (GO:0002281)3.45323532
28regulation of transcription involved in cell fate commitment (GO:0060850)3.44660428
29RNA destabilization (GO:0050779)3.37078674
30cellular response to pH (GO:0071467)3.34744451
31peptide catabolic process (GO:0043171)3.34405173
32single strand break repair (GO:0000012)3.23984591
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.18091460
34microtubule polymerization or depolymerization (GO:0031109)3.15708934
35regulation of ARF GTPase activity (GO:0032312)3.14096399
36Golgi to endosome transport (GO:0006895)3.13993213
37cell-cell recognition (GO:0009988)3.13581314
38calcium ion-dependent exocytosis (GO:0017156)3.12806693
39positive regulation of type 2 immune response (GO:0002830)3.12544738
40cellular extravasation (GO:0045123)3.10995840
41positive regulation by symbiont of host defense response (GO:0052509)3.10280839
42modulation by symbiont of host defense response (GO:0052031)3.10280839
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.10280839
44modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.10280839
45positive regulation by organism of defense response of other organism involved in symbiotic interact3.10280839
46modulation by symbiont of host immune response (GO:0052553)3.10280839
47positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09680167
48histone H3-K9 demethylation (GO:0033169)3.03841663
49response to acidic pH (GO:0010447)3.02947043
50microtubule severing (GO:0051013)3.02564061
51spermatogenesis (GO:0007283)3.00626915
52male gamete generation (GO:0048232)2.98842466
53positive regulation of gamma-delta T cell activation (GO:0046645)2.98587797
54homeostasis of number of cells within a tissue (GO:0048873)2.98033149
55response to pheromone (GO:0019236)2.96562710
56regulation of type 2 immune response (GO:0002828)2.94293557
57regulation of gamma-delta T cell activation (GO:0046643)2.90399694
58negative regulation of type 2 immune response (GO:0002829)2.90197392
59cellular response to type I interferon (GO:0071357)2.89300705
60type I interferon signaling pathway (GO:0060337)2.89300705
61antigen processing and presentation of endogenous antigen (GO:0019883)2.87014474
62membrane protein intracellular domain proteolysis (GO:0031293)2.85607422
63response to type I interferon (GO:0034340)2.85293739
64cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.81666214
65leukocyte aggregation (GO:0070486)2.77993292
66positive regulation of histone deacetylation (GO:0031065)2.77813250
67response to muramyl dipeptide (GO:0032495)2.75361293
68binding of sperm to zona pellucida (GO:0007339)2.74695001
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73811226
70regulation of gamma-delta T cell differentiation (GO:0045586)2.73281948
71protein localization to Golgi apparatus (GO:0034067)2.72441734
72negative regulation of lymphocyte mediated immunity (GO:0002707)2.70192216
73centriole replication (GO:0007099)2.69244711
74positive regulation of myotube differentiation (GO:0010831)2.66831653
75gamete generation (GO:0007276)2.65904005
76natural killer cell differentiation (GO:0001779)2.65325222
77centriole assembly (GO:0098534)2.64257370
78regulation of histone H3-K27 methylation (GO:0061085)2.62645320
79detection of other organism (GO:0098543)2.61497855
80protein polyglutamylation (GO:0018095)2.61289352
81response to interleukin-15 (GO:0070672)2.57721120
82retinoic acid receptor signaling pathway (GO:0048384)2.55678020
83regulation of B cell receptor signaling pathway (GO:0050855)2.54914972
84germinal center formation (GO:0002467)2.54508819
85detection of bacterium (GO:0016045)2.54168640
86response to peptidoglycan (GO:0032494)2.52295727
87positive regulation of T cell mediated cytotoxicity (GO:0001916)2.49031971
88production of molecular mediator involved in inflammatory response (GO:0002532)2.47751377
89peptidyl-threonine dephosphorylation (GO:0035970)2.47204228
90negative regulation of leukocyte mediated immunity (GO:0002704)2.47070278
91regulation of inclusion body assembly (GO:0090083)2.46915053
92myeloid cell activation involved in immune response (GO:0002275)2.46839919
93regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.46295922
94regulation of natural killer cell mediated immunity (GO:0002715)2.46295922
95detection of molecule of bacterial origin (GO:0032490)2.44710923
96regulation of mast cell degranulation (GO:0043304)2.44253869
97hyaluronan catabolic process (GO:0030214)2.42910724
98JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.42272251
99single fertilization (GO:0007338)2.41781449
100negative regulation of granulocyte differentiation (GO:0030853)2.39522980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.91269013
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.87793815
3LXR_22292898_ChIP-Seq_THP-1_Human2.84216250
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.67836582
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63260617
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.10770208
7ELF1_20517297_ChIP-Seq_JURKAT_Human2.06958352
8BCL6_27268052_Chip-Seq_Bcells_Human2.06633981
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03405034
10SMC4_20622854_ChIP-Seq_HELA_Human2.00496562
11BCOR_27268052_Chip-Seq_Bcells_Human1.97844026
12TCF7_22412390_ChIP-Seq_EML_Mouse1.95812702
13STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93964000
14P68_20966046_ChIP-Seq_HELA_Human1.89473420
15DROSHA_22980978_ChIP-Seq_HELA_Human1.85572576
16RUNX_20019798_ChIP-Seq_JUKART_Human1.85034405
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84352207
18KDM2B_26808549_Chip-Seq_DND41_Human1.78206788
19VDR_21846776_ChIP-Seq_THP-1_Human1.77464335
20SPI1_23127762_ChIP-Seq_K562_Human1.76557389
21VDR_24763502_ChIP-Seq_THP-1_Human1.76425607
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.72292843
23MYC_22102868_ChIP-Seq_BL_Human1.71385293
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70481471
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70219958
26MAF_26560356_Chip-Seq_TH1_Human1.68207936
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68038342
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.66996212
29VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.66943195
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62068236
31MAF_26560356_Chip-Seq_TH2_Human1.58279872
32EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.57397187
33UTX_26944678_Chip-Seq_JUKART_Human1.53875420
34E2F1_20622854_ChIP-Seq_HELA_Human1.53756668
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.51299502
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51245681
37CTCF_27219007_Chip-Seq_Bcells_Human1.49186321
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47555254
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45358155
40SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.43495337
41TP63_22573176_ChIP-Seq_HFKS_Human1.41883430
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39976629
43PHF8_20622854_ChIP-Seq_HELA_Human1.39121167
44GATA1_19941826_ChIP-Seq_K562_Human1.38319881
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37838544
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37209244
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36179542
48MYB_26560356_Chip-Seq_TH2_Human1.35862251
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35538230
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.34986952
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33310036
52MYB_26560356_Chip-Seq_TH1_Human1.33107056
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32380739
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.32312245
55VDR_24787735_ChIP-Seq_THP-1_Human1.31858504
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31829326
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.31149241
58RAC3_21632823_ChIP-Seq_H3396_Human1.30267095
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.29966917
60VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28280534
61SPI1_20517297_ChIP-Seq_HL60_Human1.28236978
62GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28168368
63P300_27268052_Chip-Seq_Bcells_Human1.27021338
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.24984859
65SA1_27219007_Chip-Seq_Bcells_Human1.24609175
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.24140626
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22125391
68CTCF_20526341_ChIP-Seq_ESCs_Human1.22103805
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22031160
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.21495397
71P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21141149
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20780757
73KDM2B_26808549_Chip-Seq_K562_Human1.19820016
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19597239
75P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.19470008
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18524385
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.16804763
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16267087
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12842999
80RUNX1_27514584_Chip-Seq_MCF-7_Human1.12596404
81RACK7_27058665_Chip-Seq_MCF-7_Human1.11127798
82EGR1_19374776_ChIP-ChIP_THP-1_Human1.10373502
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10047084
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08492950
85NANOG_20526341_ChIP-Seq_ESCs_Human1.06997839
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06015509
87FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03332768
88ERA_21632823_ChIP-Seq_H3396_Human1.03148503
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02828688
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02517627
91CTCF_21964334_Chip-Seq_Bcells_Human1.01928612
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01548324
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00988369
94NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00691619
95RARA_24833708_ChIP-Seq_LIVER_Mouse0.99824247
96TP53_22127205_ChIP-Seq_IMR90_Human0.99668654
97OCT4_19829295_ChIP-Seq_ESCs_Human0.99540971
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99237361
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98974620
100GATA3_27048872_Chip-Seq_THYMUS_Human0.98426283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.95783045
2MP0005377_hearing/vestibular/ear_phenot4.09491074
3MP0003878_abnormal_ear_physiology4.09491074
4MP0003303_peritoneal_inflammation3.88371485
5MP0001348_abnormal_lacrimal_gland3.60276235
6MP0005451_abnormal_body_composition3.21374621
7MP0003436_decreased_susceptibility_to3.00453476
8MP0002822_catalepsy2.93781472
9MP0005670_abnormal_white_adipose2.63330125
10MP0002132_abnormal_respiratory_system2.49599418
11MP0003724_increased_susceptibility_to2.46128523
12MP0000685_abnormal_immune_system2.32214226
13MP0001835_abnormal_antigen_presentation2.31335659
14MP0003172_abnormal_lysosome_physiology2.24018993
15MP0009785_altered_susceptibility_to2.18594351
16MP0002419_abnormal_innate_immunity2.09302979
17MP0005025_abnormal_response_to2.01436152
18MP0001533_abnormal_skeleton_physiology1.99596663
19MP0004510_myositis1.96547034
20MP0005000_abnormal_immune_tolerance1.93754296
21MP0001790_abnormal_immune_system1.86959513
22MP0005387_immune_system_phenotype1.86959513
23MP0001800_abnormal_humoral_immune1.80650873
24MP0003698_abnormal_male_reproductive1.80564797
25MP0003300_gastrointestinal_ulcer1.73987600
26MP0004947_skin_inflammation1.73197449
27MP0000678_abnormal_parathyroid_gland1.71955847
28MP0009278_abnormal_bone_marrow1.71728156
29MP0003191_abnormal_cellular_cholesterol1.68764222
30MP0002723_abnormal_immune_serum1.65984359
31MP0003705_abnormal_hypodermis_morpholog1.65583697
32MP0005671_abnormal_response_to1.55359263
33MP0006082_CNS_inflammation1.55162137
34MP0005310_abnormal_salivary_gland1.54941871
35MP0002452_abnormal_antigen_presenting1.49883069
36MP0002420_abnormal_adaptive_immunity1.47215403
37MP0001819_abnormal_immune_cell1.45672972
38MP0002405_respiratory_system_inflammati1.45035677
39MP0001929_abnormal_gametogenesis1.44527415
40MP0003183_abnormal_peptide_metabolism1.43383916
41MP0003091_abnormal_cell_migration1.41632109
42MP0005464_abnormal_platelet_physiology1.37862185
43MP0009764_decreased_sensitivity_to1.37049975
44MP0002138_abnormal_hepatobiliary_system1.29671729
45MP0003763_abnormal_thymus_physiology1.22318534
46MP0009840_abnormal_foam_cell1.18113078
47MP0008469_abnormal_protein_level1.17025467
48MP0002398_abnormal_bone_marrow1.13674285
49MP0001845_abnormal_inflammatory_respons1.13111722
50MP0001958_emphysema1.13041518
51MP0005397_hematopoietic_system_phenotyp1.11678155
52MP0001545_abnormal_hematopoietic_system1.11678155
53MP0010155_abnormal_intestine_physiology1.10332638
54MP0000716_abnormal_immune_system1.08485724
55MP0009053_abnormal_anal_canal1.06644228
56MP0003879_abnormal_hair_cell1.05421394
57MP0002722_abnormal_immune_system1.02841520
58MP0002998_abnormal_bone_remodeling1.02664286
59MP0005666_abnormal_adipose_tissue1.01993429
60MP0004858_abnormal_nervous_system0.99446487
61MP0005076_abnormal_cell_differentiation0.96466326
62MP0008260_abnormal_autophagy0.96236227
63MP0000703_abnormal_thymus_morphology0.96183339
64MP0002161_abnormal_fertility/fecundity0.95410277
65MP0005164_abnormal_response_to0.93959184
66MP0005390_skeleton_phenotype0.90458769
67MP0002148_abnormal_hypersensitivity_rea0.88540523
68MP0002429_abnormal_blood_cell0.85768191
69MP0001849_ear_inflammation0.85441250
70MP0000604_amyloidosis0.84742081
71MP0005375_adipose_tissue_phenotype0.82451527
72MP0000689_abnormal_spleen_morphology0.81860269
73MP0001873_stomach_inflammation0.80985727
74MP0005058_abnormal_lysosome_morphology0.80522291
75MP0005166_decreased_susceptibility_to0.79204715
76MP0009115_abnormal_fat_cell0.78249038
77MP0003279_aneurysm0.78185720
78MP0003045_fibrosis0.77325676
79MP0000249_abnormal_blood_vessel0.76644237
80MP0005379_endocrine/exocrine_gland_phen0.76264643
81MP0002249_abnormal_larynx_morphology0.75365646
82MP0002933_joint_inflammation0.73203470
83MP0008004_abnormal_stomach_pH0.73041395
84MP0003075_altered_response_to0.69226727
85MP0003448_altered_tumor_morphology0.69200896
86MP0008874_decreased_physiological_sensi0.68375973
87MP0001765_abnormal_ion_homeostasis0.67698700
88MP0003828_pulmonary_edema0.64878064
89MP0001851_eye_inflammation0.63785005
90MP0000609_abnormal_liver_physiology0.62668212
91MP0003566_abnormal_cell_adhesion0.62452705
92MP0005023_abnormal_wound_healing0.62281386
93MP0000858_altered_metastatic_potential0.61493729
94MP0003329_amyloid_beta_deposits0.59629474
95MP0009765_abnormal_xenobiotic_induced0.58508539
96MP0000681_abnormal_thyroid_gland0.57542795
97MP0005365_abnormal_bile_salt0.57109671
98MP0004808_abnormal_hematopoietic_stem0.54410798
99MP0004883_abnormal_blood_vessel0.53583880
100MP0004233_abnormal_muscle_weight0.52138512

Predicted human phenotypes

RankGene SetZ-score
1Asymmetric septal hypertrophy (HP:0001670)5.37402339
2Severe visual impairment (HP:0001141)5.01796449
3Myositis (HP:0100614)3.77587613
4Orchitis (HP:0100796)3.70662802
5Peritonitis (HP:0002586)3.68973845
6Bell-shaped thorax (HP:0001591)3.67211843
7Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.42813490
8Retrobulbar optic neuritis (HP:0100654)3.41468994
9Optic neuritis (HP:0100653)3.41468994
10Gastrointestinal infarctions (HP:0005244)3.35802037
11Nasal polyposis (HP:0100582)3.27490587
12Recurrent bacterial skin infections (HP:0005406)3.24561831
13Recurrent abscess formation (HP:0002722)3.18419588
14Abnormality of macrophages (HP:0004311)3.11190558
15Eczematoid dermatitis (HP:0000976)3.08707346
16Hypochromic microcytic anemia (HP:0004840)2.93249004
17Hypoplastic ischia (HP:0003175)2.91454229
18Gingival bleeding (HP:0000225)2.82038258
19Gingivitis (HP:0000230)2.79999104
20Resting tremor (HP:0002322)2.76889121
21Abnormality of the nasal mucosa (HP:0000433)2.75674618
22Hypochromic anemia (HP:0001931)2.75398363
23Fatigue (HP:0012378)2.65077456
24Recurrent gram-negative bacterial infections (HP:0005420)2.58991209
25Hypoalphalipoproteinemia (HP:0003233)2.56977969
26Meningitis (HP:0001287)2.56594883
27Epiphyseal dysplasia (HP:0002656)2.53579778
28Enlarged epiphyses (HP:0010580)2.50252995
29Recurrent pneumonia (HP:0006532)2.48301687
30Obstructive lung disease (HP:0006536)2.45303403
31Chronic obstructive pulmonary disease (HP:0006510)2.45303403
32Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.40213456
33Male infertility (HP:0003251)2.38108956
34Hypertriglyceridemia (HP:0002155)2.37510204
35Abnormality of the ischium (HP:0003174)2.36549115
36Increased IgE level (HP:0003212)2.33626556
37Cellulitis (HP:0100658)2.29555170
38Abnormality of the costochondral junction (HP:0000919)2.25474633
39Deep venous thrombosis (HP:0002625)2.24946357
40Flattened epiphyses (HP:0003071)2.24156470
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.20467911
42Vasculitis (HP:0002633)2.19303304
43Abnormality of the peritoneum (HP:0002585)2.18051608
44Keratoconjunctivitis sicca (HP:0001097)2.18048614
45Arterial thrombosis (HP:0004420)2.13690431
46Facial shape deformation (HP:0011334)2.12579540
47Potter facies (HP:0002009)2.12579540
48Prolonged bleeding time (HP:0003010)2.11994564
49Increased IgM level (HP:0003496)2.10599882
50Spondylolisthesis (HP:0003302)2.09610339
51Hypoplasia of the thymus (HP:0000778)2.06320205
52Hyperkalemia (HP:0002153)2.04575646
53Cone-rod dystrophy (HP:0000548)2.04323404
54Chest pain (HP:0100749)2.02345914
55Widely patent fontanelles and sutures (HP:0004492)2.01884760
56Protuberant abdomen (HP:0001538)2.01864209
57Recurrent lower respiratory tract infections (HP:0002783)2.01794182
58Epistaxis (HP:0000421)2.01571602
59Encephalitis (HP:0002383)2.01566675
60Atrophic scars (HP:0001075)1.98653909
61Aplasia/Hypoplasia of the earlobes (HP:0009906)1.98094797
62Glomerulopathy (HP:0100820)1.97334709
63Emphysema (HP:0002097)1.95680450
64Hemorrhage of the eye (HP:0011885)1.94581179
65Slow saccadic eye movements (HP:0000514)1.93847124
66Polycythemia (HP:0001901)1.93640755
67Granulocytopenia (HP:0001913)1.92640355
68Hemoptysis (HP:0002105)1.92271161
69Bony spicule pigmentary retinopathy (HP:0007737)1.90489961
70Postural instability (HP:0002172)1.88904824
71Gastrointestinal inflammation (HP:0004386)1.88231089
72Recurrent skin infections (HP:0001581)1.85089645
73Inflammation of the large intestine (HP:0002037)1.84383321
74Pulmonary infiltrates (HP:0002113)1.84354362
75Metaphyseal cupping (HP:0003021)1.83710929
76Keratoconjunctivitis (HP:0001096)1.82878963
77Impulsivity (HP:0100710)1.81401304
78Cervical subluxation (HP:0003308)1.80052103
79Thin bony cortex (HP:0002753)1.79556908
80Absent/shortened dynein arms (HP:0200106)1.78935349
81Dynein arm defect of respiratory motile cilia (HP:0012255)1.78935349
82Abnormality of dentin (HP:0010299)1.78922491
83Infertility (HP:0000789)1.78163686
84Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.72523609
85Protrusio acetabuli (HP:0003179)1.72497603
86Myocardial infarction (HP:0001658)1.72290517
87Joint swelling (HP:0001386)1.71822915
88Flared metaphyses (HP:0003015)1.70001568
89Leukocytosis (HP:0001974)1.68658337
90Recurrent fungal infections (HP:0002841)1.67669526
91Supernumerary ribs (HP:0005815)1.65938116
92Abnormality of the aortic arch (HP:0012303)1.65603827
93Truncal obesity (HP:0001956)1.65359967
94Easy fatigability (HP:0003388)1.65298392
95Mediastinal lymphadenopathy (HP:0100721)1.64493739
96Colitis (HP:0002583)1.64221290
97Absent epiphyses (HP:0010577)1.63818741
98Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63818741
99Osteoarthritis (HP:0002758)1.63552180
100Eosinophilia (HP:0001880)1.62091946

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.19890488
2PLK43.60184464
3SIK23.59524111
4TESK13.40100421
5ERN13.17626868
6TRIB32.43543869
7TESK22.38433227
8RIPK42.23603843
9MAP4K12.22118655
10BRD42.20850610
11CDK122.16900113
12STK382.04214392
13INSRR1.99857234
14GRK61.90922049
15MAP3K141.74627098
16JAK31.70894361
17RIPK11.69306533
18MAP2K31.58894091
19MAP3K111.48229032
20IRAK41.46534217
21TBK11.42739243
22TNK21.42640968
23KSR21.40784058
24PRPF4B1.38347760
25PDPK11.38131918
26SIK11.37791642
27MAP2K61.35356784
28TXK1.32670351
29BLK1.28466815
30TYK21.28100846
31MAP3K131.26241917
32PDK11.21450100
33CSK1.21329110
34ZAP701.18886868
35FGFR41.16666823
36MAP3K11.16021331
37MST1R1.15015463
38SIK31.13084976
39EPHB11.09712594
40MARK21.07737571
41DYRK1B1.06228986
42ICK1.05271326
43PRKD31.04387151
44MAP3K31.04385400
45MAPK151.03740263
46CAMK1G1.02118241
47SMG10.98565141
48MAP3K20.96499150
49RPS6KA20.92145669
50IKBKE0.90897961
51CSF1R0.88370346
52BTK0.84291525
53MAP3K70.83744142
54HCK0.81534859
55IKBKB0.81287305
56CDC42BPA0.80367051
57JAK10.78555157
58PIK3CG0.77960557
59NEK20.76193487
60CDK70.74183931
61MAPK110.72868794
62IRAK30.71469702
63RPS6KL10.71248623
64RPS6KC10.71248623
65TAOK10.69889333
66JAK20.64136572
67CAMK1D0.63239700
68AKT30.61858886
69PTK2B0.61420547
70CDK40.60949409
71TYRO30.60655281
72PRKD20.59557207
73PRKG20.58529551
74FGFR30.57520117
75MAP2K20.57273446
76FES0.57058813
77RPS6KA60.56966148
78TTN0.56548380
79RPS6KA10.54957031
80SYK0.54387834
81TAOK20.52020884
82KIT0.51782476
83EEF2K0.51780167
84PRKAA20.51669580
85MARK30.50176456
86LCK0.49697223
87PTK60.47893150
88CHUK0.47886481
89MTOR0.47405629
90PDGFRA0.45617809
91FGR0.44526339
92WNK10.44263314
93LYN0.43028441
94LATS10.41725547
95MAP3K80.41207703
96NEK60.40572437
97BRAF0.39975026
98MAP3K100.38679679
99PLK20.38275726
100PKN20.37973190

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.31293050
2Osteoclast differentiation_Homo sapiens_hsa043802.17425629
3B cell receptor signaling pathway_Homo sapiens_hsa046622.15830546
4Fatty acid biosynthesis_Homo sapiens_hsa000612.05791869
5Leishmaniasis_Homo sapiens_hsa051401.97525259
6Acute myeloid leukemia_Homo sapiens_hsa052211.93390805
7Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.92954492
8Allograft rejection_Homo sapiens_hsa053301.82643183
9Autoimmune thyroid disease_Homo sapiens_hsa053201.72367316
10Adipocytokine signaling pathway_Homo sapiens_hsa049201.70738668
11Staphylococcus aureus infection_Homo sapiens_hsa051501.63064112
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56059356
13Antigen processing and presentation_Homo sapiens_hsa046121.54921347
14Malaria_Homo sapiens_hsa051441.53911518
15Influenza A_Homo sapiens_hsa051641.52706293
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48472954
17Toxoplasmosis_Homo sapiens_hsa051451.46376839
18Type I diabetes mellitus_Homo sapiens_hsa049401.45989452
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45169362
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.33010979
21Other glycan degradation_Homo sapiens_hsa005111.32783277
22Non-small cell lung cancer_Homo sapiens_hsa052231.31232187
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30665196
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30632888
25TNF signaling pathway_Homo sapiens_hsa046681.30529848
26Viral myocarditis_Homo sapiens_hsa054161.29145203
27VEGF signaling pathway_Homo sapiens_hsa043701.27949967
28Measles_Homo sapiens_hsa051621.27107508
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26484506
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.26353076
31T cell receptor signaling pathway_Homo sapiens_hsa046601.24480874
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.22165676
33Chronic myeloid leukemia_Homo sapiens_hsa052201.21181197
34African trypanosomiasis_Homo sapiens_hsa051431.20252080
35Herpes simplex infection_Homo sapiens_hsa051681.17189212
36Type II diabetes mellitus_Homo sapiens_hsa049301.12284628
37Tuberculosis_Homo sapiens_hsa051521.11629697
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11517056
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.10267086
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08674573
41Prolactin signaling pathway_Homo sapiens_hsa049171.06486740
42Chemokine signaling pathway_Homo sapiens_hsa040621.06297155
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03080906
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02918744
45Insulin resistance_Homo sapiens_hsa049311.01386528
46Hepatitis B_Homo sapiens_hsa051611.01074341
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00983026
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00268932
49Dorso-ventral axis formation_Homo sapiens_hsa043200.99430308
50Endocytosis_Homo sapiens_hsa041440.93548536
51Pancreatic cancer_Homo sapiens_hsa052120.93536536
52Phenylalanine metabolism_Homo sapiens_hsa003600.93259128
53Inositol phosphate metabolism_Homo sapiens_hsa005620.90059328
54Primary immunodeficiency_Homo sapiens_hsa053400.89803003
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.89298900
56Bladder cancer_Homo sapiens_hsa052190.85682631
57Hepatitis C_Homo sapiens_hsa051600.84563816
58Hematopoietic cell lineage_Homo sapiens_hsa046400.83192755
59Leukocyte transendothelial migration_Homo sapiens_hsa046700.82970771
60mTOR signaling pathway_Homo sapiens_hsa041500.82779547
61Platelet activation_Homo sapiens_hsa046110.81908074
62Complement and coagulation cascades_Homo sapiens_hsa046100.77637101
63Prostate cancer_Homo sapiens_hsa052150.76577791
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75763423
65Legionellosis_Homo sapiens_hsa051340.74833420
66Insulin signaling pathway_Homo sapiens_hsa049100.74682344
67Notch signaling pathway_Homo sapiens_hsa043300.73704888
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71076481
69Amoebiasis_Homo sapiens_hsa051460.70595081
70Apoptosis_Homo sapiens_hsa042100.69785409
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.68422374
72PPAR signaling pathway_Homo sapiens_hsa033200.66458210
73Choline metabolism in cancer_Homo sapiens_hsa052310.66261214
74Endometrial cancer_Homo sapiens_hsa052130.63530080
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63284943
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.63195164
77Estrogen signaling pathway_Homo sapiens_hsa049150.60872478
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60769212
79Focal adhesion_Homo sapiens_hsa045100.60107478
80Shigellosis_Homo sapiens_hsa051310.60078085
81MAPK signaling pathway_Homo sapiens_hsa040100.59877919
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59710711
83Pertussis_Homo sapiens_hsa051330.59525986
84Renal cell carcinoma_Homo sapiens_hsa052110.57643316
85Viral carcinogenesis_Homo sapiens_hsa052030.57458859
86Protein digestion and absorption_Homo sapiens_hsa049740.56222290
87Prion diseases_Homo sapiens_hsa050200.54098098
88Small cell lung cancer_Homo sapiens_hsa052220.53623259
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.53029100
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52448118
91Olfactory transduction_Homo sapiens_hsa047400.52151120
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.51667204
93FoxO signaling pathway_Homo sapiens_hsa040680.51295766
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50000216
95Glioma_Homo sapiens_hsa052140.49855290
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49360655
97HTLV-I infection_Homo sapiens_hsa051660.48933061
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44082600
99Phagosome_Homo sapiens_hsa041450.43249820
100Lysosome_Homo sapiens_hsa041420.42915784

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