TBC1D3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.92668443
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.71570257
3antigen processing and presentation of endogenous antigen (GO:0019883)4.54829732
4regulation of ARF GTPase activity (GO:0032312)4.51934207
5negative regulation of cell killing (GO:0031342)4.33593499
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.33593499
7positive regulation of gamma-delta T cell activation (GO:0046645)3.65135059
8negative regulation of erythrocyte differentiation (GO:0045647)3.64529559
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.54885760
10macrophage activation involved in immune response (GO:0002281)3.43726626
11detection of bacterium (GO:0016045)3.42358065
12detection of other organism (GO:0098543)3.40846461
13mannose metabolic process (GO:0006013)3.39941333
14regulation of T-helper 2 cell differentiation (GO:0045628)3.39480280
15response to muramyl dipeptide (GO:0032495)3.31862868
16neutrophil activation involved in immune response (GO:0002283)3.27917191
17positive regulation of Cdc42 GTPase activity (GO:0043089)3.26840084
18germinal center formation (GO:0002467)3.22259496
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.19304544
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.19304544
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.19304544
22modulation by symbiont of host immune response (GO:0052553)3.19304544
23positive regulation by symbiont of host defense response (GO:0052509)3.19304544
24modulation by symbiont of host defense response (GO:0052031)3.19304544
25histone H3-K9 demethylation (GO:0033169)3.14682584
26positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.13677662
27response to peptidoglycan (GO:0032494)3.05661137
28maintenance of gastrointestinal epithelium (GO:0030277)3.00499762
29histone H4 deacetylation (GO:0070933)2.99532904
30regulation of gamma-delta T cell activation (GO:0046643)2.92778326
31NIK/NF-kappaB signaling (GO:0038061)2.92647573
32detection of external biotic stimulus (GO:0098581)2.92056814
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.91760928
34negative regulation of type 2 immune response (GO:0002829)2.90959554
35regulation of ARF protein signal transduction (GO:0032012)2.89215777
36leukocyte aggregation (GO:0070486)2.83239435
37negative regulation of lymphocyte mediated immunity (GO:0002707)2.77873732
38regulation of myeloid leukocyte mediated immunity (GO:0002886)2.75051312
39response to type I interferon (GO:0034340)2.73562470
40Arp2/3 complex-mediated actin nucleation (GO:0034314)2.73314926
41type I interferon signaling pathway (GO:0060337)2.71919650
42cellular response to type I interferon (GO:0071357)2.71919650
43signal complex assembly (GO:0007172)2.70567689
44negative regulation of leukocyte mediated immunity (GO:0002704)2.69673129
45regulation of mast cell degranulation (GO:0043304)2.69597145
46positive regulation of histone deacetylation (GO:0031065)2.69561490
47regulation of leukocyte degranulation (GO:0043300)2.67792559
48detection of molecule of bacterial origin (GO:0032490)2.66853861
49regulation of gamma-delta T cell differentiation (GO:0045586)2.66389707
50positive regulation of protein kinase C signaling (GO:0090037)2.65329849
51immunoglobulin mediated immune response (GO:0016064)2.65045098
52regulation of type 2 immune response (GO:0002828)2.61973798
53positive regulation of Rap GTPase activity (GO:0032854)2.61588891
54cellular extravasation (GO:0045123)2.61072393
55semaphorin-plexin signaling pathway (GO:0071526)2.60191432
56thymic T cell selection (GO:0045061)2.59401860
57epithelial structure maintenance (GO:0010669)2.59202269
58positive regulation of type 2 immune response (GO:0002830)2.56267448
59regulation of interferon-beta biosynthetic process (GO:0045357)2.55028840
60activation of Rac GTPase activity (GO:0032863)2.53148236
61histone H3 deacetylation (GO:0070932)2.52847969
62positive thymic T cell selection (GO:0045059)2.52592664
63regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51886824
64regulation of B cell receptor signaling pathway (GO:0050855)2.48112771
65detection of biotic stimulus (GO:0009595)2.45490155
66neutrophil activation (GO:0042119)2.45174343
67regulation of necroptotic process (GO:0060544)2.43447361
68negative regulation of myotube differentiation (GO:0010832)2.42483534
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.42341248
70histone lysine demethylation (GO:0070076)2.42333154
71activation of JUN kinase activity (GO:0007257)2.42264197
72histone demethylation (GO:0016577)2.42034589
73T cell selection (GO:0045058)2.41895620
74positive regulation of cellular amide metabolic process (GO:0034250)2.40919771
75positive regulation of CREB transcription factor activity (GO:0032793)2.40279763
76regulation of mast cell activation involved in immune response (GO:0033006)2.40171361
77positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.37398566
78negative thymic T cell selection (GO:0045060)2.35897651
79regulation of regulated secretory pathway (GO:1903305)2.35401592
80negative regulation of cell size (GO:0045792)2.34303904
81regulation of hydrogen peroxide metabolic process (GO:0010310)2.34044191
82negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.32245261
83phospholipid scrambling (GO:0017121)2.30634024
84negative regulation of innate immune response (GO:0045824)2.29597663
85negative regulation of alpha-beta T cell activation (GO:0046636)2.28653266
86positive regulation of protein deacetylation (GO:0090312)2.28317801
87response to laminar fluid shear stress (GO:0034616)2.26979869
88regulation of dendritic cell antigen processing and presentation (GO:0002604)2.26171195
89actin filament polymerization (GO:0030041)2.25953236
90negative regulation of interleukin-8 production (GO:0032717)2.25828868
91positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.25775609
92negative regulation of cytokine production involved in immune response (GO:0002719)2.25554974
93granulocyte activation (GO:0036230)2.25512296
94B cell receptor signaling pathway (GO:0050853)2.25357598
95macrophage activation (GO:0042116)2.24362778
96defense response to protozoan (GO:0042832)2.24189637
97peptide catabolic process (GO:0043171)2.23104406
98intracellular estrogen receptor signaling pathway (GO:0030520)2.21647853
99response to manganese ion (GO:0010042)2.21388713
100myeloid cell activation involved in immune response (GO:0002275)2.20990396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.98748379
2KDM2B_26808549_Chip-Seq_SUP-B15_Human2.66389131
3VDR_21846776_ChIP-Seq_THP-1_Human2.61678967
4LXR_22292898_ChIP-Seq_THP-1_Human2.54735058
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.54193251
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.42893992
7TCF7_22412390_ChIP-Seq_EML_Mouse2.32241681
8KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.26986655
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.24957469
10KDM2B_26808549_Chip-Seq_DND41_Human2.24583062
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17718507
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.13754158
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12691027
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96178141
15MYC_22102868_ChIP-Seq_BL_Human1.95511523
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.93728760
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93055861
18RACK7_27058665_Chip-Seq_MCF-7_Human1.90431999
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87679636
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85805039
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.85558247
22VDR_24763502_ChIP-Seq_THP-1_Human1.82845844
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81335765
24DROSHA_22980978_ChIP-Seq_HELA_Human1.80535489
25CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.78696535
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77353322
27KDM2B_26808549_Chip-Seq_K562_Human1.77183034
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.74687064
29SMC4_20622854_ChIP-Seq_HELA_Human1.70708138
30P68_20966046_ChIP-Seq_HELA_Human1.69199977
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68834590
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67786188
33SPI1_23127762_ChIP-Seq_K562_Human1.66255195
34UTX_26944678_Chip-Seq_JUKART_Human1.65707026
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65468255
36MAF_26560356_Chip-Seq_TH1_Human1.65295465
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64876866
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61328379
39MAF_26560356_Chip-Seq_TH2_Human1.60655315
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.56514007
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55610410
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.54495651
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54470939
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52546761
45GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52368423
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.51490511
47RUNX1_27514584_Chip-Seq_MCF-7_Human1.50062983
48BCL6_27268052_Chip-Seq_Bcells_Human1.48906771
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47881402
50BCOR_27268052_Chip-Seq_Bcells_Human1.46736255
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45319352
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43792542
53STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43786129
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.42818741
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.40957169
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39984265
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.37113143
58CREB1_26743006_Chip-Seq_LNCaP_Human1.36056726
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.34921841
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32243678
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31465101
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27913047
63ESR1_20079471_ChIP-ChIP_T-47D_Human1.27763823
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.27619860
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26888185
66MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26221133
67UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25937399
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.24899378
69SCL_19346495_ChIP-Seq_HPC-7_Human1.24739776
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24529976
71FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21593988
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20034745
73TP63_22573176_ChIP-Seq_HFKS_Human1.19678335
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19008145
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.18141578
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.17671303
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17151567
78CTCF_27219007_Chip-Seq_Bcells_Human1.16171564
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15103930
80RUNX_20019798_ChIP-Seq_JUKART_Human1.11703797
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11052630
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.10836240
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10729228
84ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10311158
85PHF8_20622854_ChIP-Seq_HELA_Human1.08823728
86E2F1_20622854_ChIP-Seq_HELA_Human1.08823163
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.07329654
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06499093
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05883547
90OCT4_19829295_ChIP-Seq_ESCs_Human1.05185405
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05173406
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03756152
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03498649
94PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02462295
95NCOR1_26117541_ChIP-Seq_K562_Human1.00331898
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99339475
97P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99231822
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98868805
99GATA1_19941826_ChIP-Seq_K562_Human0.98608284
100SA1_27219007_Chip-Seq_Bcells_Human0.98540673

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.32996914
2MP0003172_abnormal_lysosome_physiology3.27422202
3MP0003303_peritoneal_inflammation3.01761407
4MP0001835_abnormal_antigen_presentation2.95052546
5MP0005058_abnormal_lysosome_morphology2.77983955
6MP0003724_increased_susceptibility_to2.74161830
7MP0005451_abnormal_body_composition2.67597524
8MP0008260_abnormal_autophagy2.66020840
9MP0003191_abnormal_cellular_cholesterol2.57866795
10MP0008004_abnormal_stomach_pH2.29293244
11MP0009278_abnormal_bone_marrow2.28250169
12MP0005025_abnormal_response_to2.23299431
13MP0002419_abnormal_innate_immunity2.22479227
14MP0003183_abnormal_peptide_metabolism2.21417175
15MP0010155_abnormal_intestine_physiology2.14140223
16MP0004947_skin_inflammation1.99922918
17MP0001790_abnormal_immune_system1.99267660
18MP0005387_immune_system_phenotype1.99267660
19MP0003705_abnormal_hypodermis_morpholog1.99237586
20MP0001800_abnormal_humoral_immune1.88841286
21MP0009785_altered_susceptibility_to1.86956261
22MP0005000_abnormal_immune_tolerance1.86499104
23MP0003300_gastrointestinal_ulcer1.85006866
24MP0005409_darkened_coat_color1.83775636
25MP0002723_abnormal_immune_serum1.75853260
26MP0000685_abnormal_immune_system1.75058150
27MP0005671_abnormal_response_to1.70887042
28MP0004264_abnormal_extraembryonic_tissu1.68652546
29MP0002420_abnormal_adaptive_immunity1.68388634
30MP0001819_abnormal_immune_cell1.67594526
31MP0005076_abnormal_cell_differentiation1.66964008
32MP0002822_catalepsy1.64194190
33MP0006082_CNS_inflammation1.63444934
34MP0002452_abnormal_antigen_presenting1.62362192
35MP0003763_abnormal_thymus_physiology1.58841370
36MP0003453_abnormal_keratinocyte_physiol1.58204899
37MP0001348_abnormal_lacrimal_gland1.58080928
38MP0004510_myositis1.57208368
39MP0005397_hematopoietic_system_phenotyp1.57100974
40MP0001545_abnormal_hematopoietic_system1.57100974
41MP0009840_abnormal_foam_cell1.53996752
42MP0001849_ear_inflammation1.51790238
43MP0004381_abnormal_hair_follicle1.49782311
44MP0001533_abnormal_skeleton_physiology1.47179539
45MP0005377_hearing/vestibular/ear_phenot1.44497091
46MP0003878_abnormal_ear_physiology1.44497091
47MP0003866_abnormal_defecation1.43677876
48MP0002132_abnormal_respiratory_system1.42190742
49MP0005310_abnormal_salivary_gland1.41772549
50MP0002138_abnormal_hepatobiliary_system1.38979789
51MP0000465_gastrointestinal_hemorrhage1.34289517
52MP0002405_respiratory_system_inflammati1.34100750
53MP0010234_abnormal_vibrissa_follicle1.31523980
54MP0002998_abnormal_bone_remodeling1.30816116
55MP0002148_abnormal_hypersensitivity_rea1.28156962
56MP0002796_impaired_skin_barrier1.26021276
57MP0003879_abnormal_hair_cell1.25887381
58MP0000716_abnormal_immune_system1.25437921
59MP0000858_altered_metastatic_potential1.24223691
60MP0002398_abnormal_bone_marrow1.22091703
61MP0001958_emphysema1.21127510
62MP0005464_abnormal_platelet_physiology1.20825224
63MP0005666_abnormal_adipose_tissue1.18439149
64MP0002396_abnormal_hematopoietic_system1.14596812
65MP0004858_abnormal_nervous_system1.14315066
66MP0001845_abnormal_inflammatory_respons1.13563027
67MP0003045_fibrosis1.12754790
68MP0003091_abnormal_cell_migration1.09569672
69MP0003690_abnormal_glial_cell1.07272764
70MP0000678_abnormal_parathyroid_gland1.06575529
71MP0003279_aneurysm1.02427859
72MP0001873_stomach_inflammation0.98801633
73MP0005375_adipose_tissue_phenotype0.97738513
74MP0002249_abnormal_larynx_morphology0.97589273
75MP0002722_abnormal_immune_system0.96484627
76MP0005257_abnormal_intraocular_pressure0.96397050
77MP0000703_abnormal_thymus_morphology0.94947009
78MP0002429_abnormal_blood_cell0.94281353
79MP0004185_abnormal_adipocyte_glucose0.92626265
80MP0008874_decreased_physiological_sensi0.92364181
81MP0003656_abnormal_erythrocyte_physiolo0.92251502
82MP0008469_abnormal_protein_level0.91983174
83MP0004859_abnormal_synaptic_plasticity0.90713574
84MP0005166_decreased_susceptibility_to0.88702209
85MP0001851_eye_inflammation0.88374772
86MP0003828_pulmonary_edema0.84197059
87MP0003075_altered_response_to0.84125887
88MP0009931_abnormal_skin_appearance0.80658255
89MP0000689_abnormal_spleen_morphology0.80494362
90MP0001663_abnormal_digestive_system0.79913459
91MP0002933_joint_inflammation0.78582602
92MP0004808_abnormal_hematopoietic_stem0.77581762
93MP0002089_abnormal_postnatal_growth/wei0.75377527
94MP0005390_skeleton_phenotype0.74071344
95MP0009764_decreased_sensitivity_to0.73618474
96MP0000003_abnormal_adipose_tissue0.72690358
97MP0001853_heart_inflammation0.72218243
98MP0009333_abnormal_splenocyte_physiolog0.71364017
99MP0005023_abnormal_wound_healing0.66368918
100MP0000490_abnormal_crypts_of0.64472351

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.01506805
2Obstructive sleep apnea (HP:0002870)3.38029149
3Myositis (HP:0100614)3.36233332
4Recurrent bacterial skin infections (HP:0005406)3.30953557
5Increased IgE level (HP:0003212)3.22241918
6Recurrent abscess formation (HP:0002722)3.18569331
7Pustule (HP:0200039)3.05610539
8Thin bony cortex (HP:0002753)3.03480899
9Orchitis (HP:0100796)3.03063028
10Abnormality of macrophages (HP:0004311)2.99313104
11Cerebral aneurysm (HP:0004944)2.96546097
12Broad face (HP:0000283)2.89701170
13Gingivitis (HP:0000230)2.89296986
14Metaphyseal cupping (HP:0003021)2.70572930
15Upper limb amyotrophy (HP:0009129)2.66221434
16Distal upper limb amyotrophy (HP:0007149)2.66221434
17Optic neuritis (HP:0100653)2.66069360
18Retrobulbar optic neuritis (HP:0100654)2.66069360
19Recurrent gram-negative bacterial infections (HP:0005420)2.66051921
20Chronic otitis media (HP:0000389)2.63400187
21Cervical subluxation (HP:0003308)2.62888741
22Abnormality of the fingertips (HP:0001211)2.58652733
23Nuclear cataract (HP:0100018)2.54924448
24Malnutrition (HP:0004395)2.49652816
25Peritonitis (HP:0002586)2.47726503
26Hemorrhage of the eye (HP:0011885)2.46663290
27Nasal polyposis (HP:0100582)2.45638864
28Gastrointestinal infarctions (HP:0005244)2.44281267
29Ankle clonus (HP:0011448)2.43069467
30Supranuclear gaze palsy (HP:0000605)2.38708991
31Cellulitis (HP:0100658)2.36178909
32Gastrointestinal inflammation (HP:0004386)2.35791336
33Colitis (HP:0002583)2.35159909
34Dysostosis multiplex (HP:0000943)2.27801997
35Distal lower limb amyotrophy (HP:0008944)2.27726217
36Inflammation of the large intestine (HP:0002037)2.25861646
37Abnormality of the nasal mucosa (HP:0000433)2.24486294
38Recurrent fungal infections (HP:0002841)2.22683699
39Emphysema (HP:0002097)2.20548720
40Spondylolisthesis (HP:0003302)2.20352731
41J-shaped sella turcica (HP:0002680)2.13801842
42Chronic obstructive pulmonary disease (HP:0006510)2.13596869
43Obstructive lung disease (HP:0006536)2.13596869
44Axonal loss (HP:0003447)2.11051363
45Recurrent skin infections (HP:0001581)2.09231660
46Neuronal loss in central nervous system (HP:0002529)2.08108653
47Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06937225
48Abnormality of polysaccharide metabolism (HP:0011012)2.06937225
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06937225
50Meningitis (HP:0001287)2.06174330
51Mediastinal lymphadenopathy (HP:0100721)2.04709381
52Keratoconjunctivitis sicca (HP:0001097)2.03439005
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02865062
54Mucopolysacchariduria (HP:0008155)1.99925267
55Urinary glycosaminoglycan excretion (HP:0003541)1.99925267
56Hand muscle atrophy (HP:0009130)1.99907211
57Abnormality of the peritoneum (HP:0002585)1.97014706
58Prolonged bleeding time (HP:0003010)1.96930351
59Vasculitis (HP:0002633)1.94992928
60Slow saccadic eye movements (HP:0000514)1.94513789
61Hemoptysis (HP:0002105)1.92645320
62Premature loss of primary teeth (HP:0006323)1.92280672
63Elevated erythrocyte sedimentation rate (HP:0003565)1.91577166
64Chest pain (HP:0100749)1.89705931
65Aneurysm (HP:0002617)1.88516777
66Hypertriglyceridemia (HP:0002155)1.87880555
67Systemic lupus erythematosus (HP:0002725)1.86322150
68Flattened epiphyses (HP:0003071)1.84353264
69Increased connective tissue (HP:0009025)1.83728757
70Easy fatigability (HP:0003388)1.83233888
71Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.82080284
72Hypochromic anemia (HP:0001931)1.81451884
73Difficulty climbing stairs (HP:0003551)1.80694455
74Gingival bleeding (HP:0000225)1.79476787
75Keratoconjunctivitis (HP:0001096)1.78435134
76Stridor (HP:0010307)1.78434188
77Abnormality of the aortic arch (HP:0012303)1.78118818
78Abnormal delayed hypersensitivity skin test (HP:0002963)1.77652420
79Polygenic inheritance (HP:0010982)1.77537481
80Neurofibrillary tangles (HP:0002185)1.76547851
81Fragile skin (HP:0001030)1.76480112
82Long palpebral fissure (HP:0000637)1.76466429
83Enlarged epiphyses (HP:0010580)1.76363677
84Atrophic scars (HP:0001075)1.75954520
85Joint stiffness (HP:0001387)1.74126835
86Papilledema (HP:0001085)1.72992376
87Onion bulb formation (HP:0003383)1.72972069
88Pulmonary infiltrates (HP:0002113)1.71130741
89Loss of speech (HP:0002371)1.70930279
90Biconcave vertebral bodies (HP:0004586)1.69121922
91Recurrent bronchitis (HP:0002837)1.68676152
92Flat acetabular roof (HP:0003180)1.68210717
93Amyloidosis (HP:0011034)1.66764678
94Epistaxis (HP:0000421)1.65889224
95Thick nail (HP:0001805)1.64152326
96Encephalitis (HP:0002383)1.61422368
97Thoracic kyphosis (HP:0002942)1.60932565
98Joint swelling (HP:0001386)1.58006294
99Spinal canal stenosis (HP:0003416)1.57656619
100Granulocytopenia (HP:0001913)1.57163608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K133.44905945
2ERN13.22603472
3TRIB32.89677751
4MST1R2.62999371
5TNK22.62032060
6RIPK42.54983926
7SIK12.50111289
8SIK22.47518657
9MAP4K12.31279739
10RIPK12.23272274
11MAP2K32.19932751
12PRPF4B2.03858498
13SIK31.95367180
14CDK121.87990883
15TYK21.72784510
16MARK21.72455030
17MAP3K71.60979164
18MAP3K141.59427438
19BLK1.58785188
20EPHB11.45595722
21ZAP701.43509737
22MAP3K31.41696141
23TAOK11.40225799
24MAP3K61.39939834
25MAP2K61.37923882
26IRAK41.37077283
27EPHA21.36805037
28LMTK21.33431368
29PRKD21.31715793
30TBK11.31683469
31GRK61.27946815
32MAP3K111.21912686
33PKN21.20555690
34CDC42BPA1.18111199
35FGFR41.17697069
36FES1.12833679
37CSK1.11074165
38CSF1R1.05739276
39FGR1.04874247
40MET1.04851874
41KSR21.02921575
42PTK61.02673987
43ICK1.02205218
44JAK31.01272381
45TESK10.99527803
46BRD40.99235870
47MAP3K10.94545253
48PDPK10.93333631
49PRKD30.93223558
50BMX0.90417495
51BTK0.85988866
52PDK10.84241281
53HCK0.83290966
54STK380.82697451
55DDR20.82476634
56JAK10.80628630
57PDGFRA0.79029313
58DAPK20.76556498
59MATK0.70559044
60IKBKE0.69245335
61CAMKK10.69238919
62TAOK20.68674431
63RPS6KA20.66353441
64ERBB20.65631133
65IKBKB0.62953345
66RPS6KL10.62376618
67RPS6KC10.62376618
68PRKG20.62307918
69DYRK1B0.61014342
70JAK20.60149505
71TESK20.58923601
72SMG10.58694387
73CAMK1D0.58329230
74SGK30.58186115
75PDGFRB0.58007062
76PTK2B0.57610645
77MTOR0.57152058
78WNK10.55284654
79IRAK30.55250902
80LCK0.53461587
81CHUK0.52497925
82TYRO30.52304592
83MAPK120.50815567
84BMPR20.50193913
85NME10.48367250
86LYN0.47484651
87WNK40.46905250
88KIT0.46654665
89PRKCH0.46139665
90RPS6KA60.45425936
91MARK30.45035334
92HIPK20.44709213
93RET0.44276587
94MAPK70.43877014
95CAMK1G0.41956716
96SYK0.41603896
97PRKAA20.41414240
98FYN0.40332548
99FGFR30.39423837
100TXK0.38372217

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.47604067
2Osteoclast differentiation_Homo sapiens_hsa043802.14646889
3Leishmaniasis_Homo sapiens_hsa051401.90672547
4Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.81613625
5Acute myeloid leukemia_Homo sapiens_hsa052211.77456011
6Staphylococcus aureus infection_Homo sapiens_hsa051501.72268973
7B cell receptor signaling pathway_Homo sapiens_hsa046621.65032153
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54574075
9VEGF signaling pathway_Homo sapiens_hsa043701.53071320
10Notch signaling pathway_Homo sapiens_hsa043301.49556076
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48614717
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47333349
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.46271314
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42130358
15Tuberculosis_Homo sapiens_hsa051521.37841866
16Toxoplasmosis_Homo sapiens_hsa051451.31591071
17TNF signaling pathway_Homo sapiens_hsa046681.31135145
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30517172
19Graft-versus-host disease_Homo sapiens_hsa053321.28928269
20Chronic myeloid leukemia_Homo sapiens_hsa052201.26987351
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26210788
22GnRH signaling pathway_Homo sapiens_hsa049121.19549723
23Allograft rejection_Homo sapiens_hsa053301.18459403
24Inositol phosphate metabolism_Homo sapiens_hsa005621.18371954
25T cell receptor signaling pathway_Homo sapiens_hsa046601.17407732
26Hepatitis C_Homo sapiens_hsa051601.15542627
27Influenza A_Homo sapiens_hsa051641.13366639
28Choline metabolism in cancer_Homo sapiens_hsa052311.13356024
29Non-small cell lung cancer_Homo sapiens_hsa052231.12899236
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.11782779
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10502445
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.10191686
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08730189
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.06415835
35Malaria_Homo sapiens_hsa051441.06257684
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.04577146
37Autoimmune thyroid disease_Homo sapiens_hsa053201.03852574
38mTOR signaling pathway_Homo sapiens_hsa041501.00098145
39Antigen processing and presentation_Homo sapiens_hsa046120.99301878
40Pancreatic cancer_Homo sapiens_hsa052120.97572230
41Amoebiasis_Homo sapiens_hsa051460.97322954
42Chemokine signaling pathway_Homo sapiens_hsa040620.96252765
43Prolactin signaling pathway_Homo sapiens_hsa049170.94889721
44Neurotrophin signaling pathway_Homo sapiens_hsa047220.94223015
45Endocytosis_Homo sapiens_hsa041440.93926220
46African trypanosomiasis_Homo sapiens_hsa051430.93011921
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92964549
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92534437
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92054074
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90302899
51ErbB signaling pathway_Homo sapiens_hsa040120.90149332
52Lysosome_Homo sapiens_hsa041420.89447981
53Insulin signaling pathway_Homo sapiens_hsa049100.88829335
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.88283890
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87738351
56Insulin resistance_Homo sapiens_hsa049310.86780795
57Platelet activation_Homo sapiens_hsa046110.85938008
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.85670609
59Long-term potentiation_Homo sapiens_hsa047200.85580964
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84197960
61Dorso-ventral axis formation_Homo sapiens_hsa043200.84007594
62Herpes simplex infection_Homo sapiens_hsa051680.83740523
63Hepatitis B_Homo sapiens_hsa051610.82945351
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.80700823
65Estrogen signaling pathway_Homo sapiens_hsa049150.80611841
66Endometrial cancer_Homo sapiens_hsa052130.77631268
67Apoptosis_Homo sapiens_hsa042100.76541440
68Measles_Homo sapiens_hsa051620.76027809
69Pertussis_Homo sapiens_hsa051330.75142989
70ABC transporters_Homo sapiens_hsa020100.74457655
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74162877
72Bladder cancer_Homo sapiens_hsa052190.73494183
73Glioma_Homo sapiens_hsa052140.73407332
74Primary immunodeficiency_Homo sapiens_hsa053400.73328880
75Salmonella infection_Homo sapiens_hsa051320.72769032
76Shigellosis_Homo sapiens_hsa051310.72620003
77Viral myocarditis_Homo sapiens_hsa054160.72215079
78Hematopoietic cell lineage_Homo sapiens_hsa046400.71443170
79Renal cell carcinoma_Homo sapiens_hsa052110.70898669
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69877206
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65810306
82Type I diabetes mellitus_Homo sapiens_hsa049400.65539647
83MAPK signaling pathway_Homo sapiens_hsa040100.63718562
84Asthma_Homo sapiens_hsa053100.61326922
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58878042
86Fructose and mannose metabolism_Homo sapiens_hsa000510.58445895
87Prostate cancer_Homo sapiens_hsa052150.57967647
88Phagosome_Homo sapiens_hsa041450.57824926
89Synaptic vesicle cycle_Homo sapiens_hsa047210.57312886
90Type II diabetes mellitus_Homo sapiens_hsa049300.57174742
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57058995
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.56843340
93Legionellosis_Homo sapiens_hsa051340.56804170
94FoxO signaling pathway_Homo sapiens_hsa040680.56111767
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.54462957
96Rap1 signaling pathway_Homo sapiens_hsa040150.54281412
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54188886
98Focal adhesion_Homo sapiens_hsa045100.52624215
99Prion diseases_Homo sapiens_hsa050200.51003505
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49962871

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