ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm capacitation (GO:0048240)	8.67101358
2	chromosome condensation (GO:0030261)	8.55306422
3	spermatid nucleus differentiation (GO:0007289)	8.44623633
4	single strand break repair (GO:0000012)	8.25348763
5	DNA packaging (GO:0006323)	8.20216733
6	plasma membrane fusion (GO:0045026)	8.00739221
7	microtubule depolymerization (GO:0007019)	7.71898664
8	spermatid development (GO:0007286)	7.51181922
9	sperm-egg recognition (GO:0035036)	7.05268576
10	multicellular organism reproduction (GO:0032504)	6.81555665
11	axonemal dynein complex assembly (GO:0070286)	6.67017950
12	protein polyglutamylation (GO:0018095)	6.60678701
13	reproduction (GO:0000003)	6.40276357
14	binding of sperm to zona pellucida (GO:0007339)	6.35065312
15	microtubule polymerization or depolymerization (GO:0031109)	6.33801991
16	calcium ion-dependent exocytosis (GO:0017156)	6.22722571
17	sexual reproduction (GO:0019953)	6.16564501
18	rRNA methylation (GO:0031167)	6.05577600
19	negative regulation of inclusion body assembly (GO:0090084)	6.02779923
20	cell-cell recognition (GO:0009988)	5.84381063
21	regulation of cilium movement (GO:0003352)	5.77914144
22	centriole replication (GO:0007099)	5.77658545
23	spermatogenesis (GO:0007283)	5.73104912
24	male gamete generation (GO:0048232)	5.70990956
25	protein targeting to Golgi (GO:0000042)	5.50160529
26	cellular ketone body metabolic process (GO:0046950)	5.43276787
27	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.41877633
28	microtubule severing (GO:0051013)	5.41808314
29	establishment of protein localization to Golgi (GO:0072600)	5.28087912
30	gamete generation (GO:0007276)	5.22970444
31	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	5.15417542
32	centriole assembly (GO:0098534)	5.12712712
33	rRNA modification (GO:0000154)	5.08687456
34	positive regulation of Rab GTPase activity (GO:0032851)	5.07056523
35	regulation of Rab GTPase activity (GO:0032313)	5.07056523
36	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.05072220
37	phosphatidylethanolamine metabolic process (GO:0046337)	4.95402938
38	motile cilium assembly (GO:0044458)	4.94027891
39	cilium or flagellum-dependent cell motility (GO:0001539)	4.88370896
40	regulation of transcription involved in cell fate commitment (GO:0060850)	4.80085836
41	ketone body metabolic process (GO:1902224)	4.78418691
42	chromatin silencing (GO:0006342)	4.64688921
43	single fertilization (GO:0007338)	4.59806511
44	regulation of inclusion body assembly (GO:0090083)	4.56314227
45	epithelial cilium movement (GO:0003351)	4.54536400
46	germ cell development (GO:0007281)	4.30839454
47	protein localization to Golgi apparatus (GO:0034067)	4.25679068
48	regulation of centriole replication (GO:0046599)	4.25315655
49	multicellular organismal reproductive process (GO:0048609)	4.17025061
50	cilium movement (GO:0003341)	4.12422237
51	alanine transport (GO:0032328)	4.12339526
52	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.08511261
53	regulation of microtubule-based movement (GO:0060632)	4.05738915
54	cell wall macromolecule metabolic process (GO:0044036)	3.98528191
55	cell wall macromolecule catabolic process (GO:0016998)	3.95034867
56	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.87512666
57	fertilization (GO:0009566)	3.86413090
58	nucleus organization (GO:0006997)	3.75608976
59	RNA destabilization (GO:0050779)	3.65047258
60	seminiferous tubule development (GO:0072520)	3.60256048
61	negative regulation of Rho protein signal transduction (GO:0035024)	3.48812689
62	multicellular organismal movement (GO:0050879)	3.45028694
63	musculoskeletal movement (GO:0050881)	3.45028694
64	coenzyme catabolic process (GO:0009109)	3.43618101
65	microtubule nucleation (GO:0007020)	3.35333895
66	cerebral cortex neuron differentiation (GO:0021895)	3.30505341
67	organic cation transport (GO:0015695)	3.29490475
68	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.25594767
69	glycerol ether metabolic process (GO:0006662)	3.23541020
70	piRNA metabolic process (GO:0034587)	3.19874142
71	negative regulation of gene expression, epigenetic (GO:0045814)	3.17075806
72	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.15977523
73	peptidyl-threonine dephosphorylation (GO:0035970)	3.15771758
74	response to acidic pH (GO:0010447)	3.15617873
75	pattern specification involved in kidney development (GO:0061004)	3.13602981
76	polyamine biosynthetic process (GO:0006596)	3.09689217
77	cellular response to pH (GO:0071467)	3.06071876
78	ether metabolic process (GO:0018904)	3.05404225
79	cranial nerve morphogenesis (GO:0021602)	3.01813008
80	DNA methylation involved in gamete generation (GO:0043046)	3.01731150
81	multicellular organismal development (GO:0007275)	3.00585263
82	cell recognition (GO:0008037)	2.98434805
83	cell differentiation involved in metanephros development (GO:0072202)	2.95070035
84	positive regulation of skeletal muscle tissue development (GO:0048643)	2.94108336
85	regulation of hippo signaling (GO:0035330)	2.93132420
86	NAD biosynthetic process (GO:0009435)	2.88085228
87	nephron epithelium morphogenesis (GO:0072088)	2.87995790
88	nephron tubule morphogenesis (GO:0072078)	2.87995790
89	urinary tract smooth muscle contraction (GO:0014848)	2.86945223
90	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.84584531
91	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.84584531
92	regulation of somitogenesis (GO:0014807)	2.84582972
93	regulation of interleukin-13 production (GO:0032656)	2.84098206
94	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.82800748
95	mitotic G1 DNA damage checkpoint (GO:0031571)	2.81398439
96	spinal cord motor neuron differentiation (GO:0021522)	2.80917622
97	acrosome reaction (GO:0007340)	11.3880098
98	sperm motility (GO:0030317)	11.0412913
99	fusion of sperm to egg plasma membrane (GO:0007342)	10.5895438
100	response to pheromone (GO:0019236)	10.2509235

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.58841596
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.09501904
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.98809334
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.94982390
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.79420728
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.47092576
7	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.22178267
8	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22178267
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.21025714
10	DROSHA_22980978_ChIP-Seq_HELA_Human	1.99177404
11	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.94324946
12	CBP_20019798_ChIP-Seq_JUKART_Human	1.94324946
13	ZNF274_21170338_ChIP-Seq_K562_Hela	1.92294282
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.90460383
15	ERA_21632823_ChIP-Seq_H3396_Human	1.89770263
16	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.89398216
17	FUS_26573619_Chip-Seq_HEK293_Human	1.86793163
18	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.85636395
19	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.83530519
20	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.82382886
21	CTCF_27219007_Chip-Seq_Bcells_Human	1.79975047
22	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.77623324
23	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.76999935
24	RAC3_21632823_ChIP-Seq_H3396_Human	1.75256572
25	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.73789357
26	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.72531946
27	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.72218774
28	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.70535349
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70455862
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.69535693
31	NANOG_20526341_ChIP-Seq_ESCs_Human	1.69095721
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67926548
33	TAF2_19829295_ChIP-Seq_ESCs_Human	1.60153799
34	BCL6_27268052_Chip-Seq_Bcells_Human	1.59205883
35	E2F1_20622854_ChIP-Seq_HELA_Human	1.58395892
36	* WDR5_24793694_ChIP-Seq_LNCAP_Human	1.55853781
37	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.54271671
38	MYC_19829295_ChIP-Seq_ESCs_Human	1.51686817
39	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.49348878
40	AR_25329375_ChIP-Seq_VCAP_Human	1.48556609
41	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47473077
42	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.46974253
43	CTCF_20526341_ChIP-Seq_ESCs_Human	1.42260187
44	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.40950742
45	* SMC4_20622854_ChIP-Seq_HELA_Human	1.39996359
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.39430416
47	* TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.39089008
48	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.38913782
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37785672
50	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.36587207
51	AR_21572438_ChIP-Seq_LNCaP_Human	1.36525016
52	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.36039356
53	* OCT4_20526341_ChIP-Seq_ESCs_Human	1.35070897
54	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.34909987
55	BCOR_27268052_Chip-Seq_Bcells_Human	1.30323037
56	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.30102534
57	P300_19829295_ChIP-Seq_ESCs_Human	1.29778742
58	P68_20966046_ChIP-Seq_HELA_Human	1.27514099
59	* PHF8_20622854_ChIP-Seq_HELA_Human	1.26558513
60	ERG_20517297_ChIP-Seq_VCAP_Human	1.25398816
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25253337
62	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23264048
63	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.22135661
64	P53_21459846_ChIP-Seq_SAOS-2_Human	1.20798359
65	P300_27268052_Chip-Seq_Bcells_Human	1.20609181
66	REST_21632747_ChIP-Seq_MESCs_Mouse	1.20013676
67	TP63_22573176_ChIP-Seq_HFKS_Human	1.18795941
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17869617
69	TP53_18474530_ChIP-ChIP_U2OS_Human	1.17578995
70	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.16528208
71	TAF15_26573619_Chip-Seq_HEK293_Human	1.15674097
72	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15248520
73	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.14637451
74	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.14495478
75	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.14420344
76	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.13413807
77	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.12555108
78	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.12519597
79	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.11459012
80	NCOR_22424771_ChIP-Seq_293T_Human	1.10634619
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09644606
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09441381
83	ETV1_20927104_ChIP-Seq_GIST48_Human	1.09057202
84	SMRT_27268052_Chip-Seq_Bcells_Human	1.07601654
85	RBPJ_21746931_ChIP-Seq_IB4_Human	1.07451255
86	LXR_22292898_ChIP-Seq_THP-1_Human	1.07103211
87	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.07006486
88	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.04874921
89	SA1_27219007_Chip-Seq_Bcells_Human	1.04389216
90	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.03775263
91	NFYB_21822215_ChIP-Seq_K562_Human	1.03127295
92	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.02860204
93	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.02636211
94	VDR_22108803_ChIP-Seq_LS180_Human	1.02102787
95	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02028854
96	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02028854
97	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.00506109
98	* CEBPB_22108803_ChIP-Seq_LS180_Human	1.00342984
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00009845
100	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00009845

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005377_hearing/vestibular/ear_phenot	5.07551381
2	MP0003878_abnormal_ear_physiology	5.07551381
3	MP0005670_abnormal_white_adipose	4.47866077
4	MP0003698_abnormal_male_reproductive	4.07162513
5	MP0001929_abnormal_gametogenesis	3.52004177
6	MP0001348_abnormal_lacrimal_gland	2.98759784
7	MP0000678_abnormal_parathyroid_gland	2.38857684
8	MP0002161_abnormal_fertility/fecundity	2.26950789
9	MP0003011_delayed_dark_adaptation	2.25888293
10	MP0003718_maternal_effect	2.15964527
11	MP0003136_yellow_coat_color	2.03288841
12	MP0005410_abnormal_fertilization	10.7846680
13	MP0001486_abnormal_startle_reflex	1.88282148
14	MP0001485_abnormal_pinna_reflex	1.81781201
15	MP0002249_abnormal_larynx_morphology	1.80324473
16	MP0005423_abnormal_somatic_nervous	1.79557355
17	MP0002234_abnormal_pharynx_morphology	1.79311849
18	MP0005379_endocrine/exocrine_gland_phen	1.73686078
19	MP0002210_abnormal_sex_determination	1.72137472
20	MP0002735_abnormal_chemical_nociception	1.71887801
21	MP0009053_abnormal_anal_canal	1.71421181
22	MP0002653_abnormal_ependyma_morphology	1.69546520
23	MP0002132_abnormal_respiratory_system	1.65532608
24	MP0001968_abnormal_touch/_nociception	1.60081672
25	MP0002282_abnormal_trachea_morphology	1.58006137
26	MP0002822_catalepsy	1.49893855
27	MP0004742_abnormal_vestibular_system	1.45401877
28	MP0000534_abnormal_ureter_morphology	1.43357240
29	MP0001145_abnormal_male_reproductive	1.37878745
30	MP0003646_muscle_fatigue	1.35285961
31	MP0000653_abnormal_sex_gland	1.33453699
32	MP0002138_abnormal_hepatobiliary_system	1.29714827
33	MP0004510_myositis	1.26062956
34	MP0008877_abnormal_DNA_methylation	1.21920205
35	MP0000026_abnormal_inner_ear	1.17846823
36	MP0006292_abnormal_olfactory_placode	1.17683892
37	MP0001963_abnormal_hearing_physiology	1.14926945
38	MP0005310_abnormal_salivary_gland	1.11903597
39	MP0002733_abnormal_thermal_nociception	1.10845346
40	MP0000049_abnormal_middle_ear	1.08905949
41	MP0001765_abnormal_ion_homeostasis	1.06692448
42	MP0000955_abnormal_spinal_cord	1.05570413
43	MP0009379_abnormal_foot_pigmentation	1.05464304
44	MP0004859_abnormal_synaptic_plasticity	1.00120893
45	MP0005551_abnormal_eye_electrophysiolog	0.99720455
46	MP0002067_abnormal_sensory_capabilities	0.95361408
47	MP0005248_abnormal_Harderian_gland	0.90224449
48	MP0000566_synostosis	0.89834835
49	MP0009745_abnormal_behavioral_response	0.89475152
50	MP0002557_abnormal_social/conspecific_i	0.88879684
51	MP0005395_other_phenotype	0.85957629
52	MP0003879_abnormal_hair_cell	0.83452750
53	MP0000681_abnormal_thyroid_gland	0.81536258
54	MP0003283_abnormal_digestive_organ	0.81227417
55	MP0000516_abnormal_urinary_system	0.77837618
56	MP0005367_renal/urinary_system_phenotyp	0.77837618
57	MP0002572_abnormal_emotion/affect_behav	0.77750880
58	MP0003137_abnormal_impulse_conducting	0.76507625
59	MP0002127_abnormal_cardiovascular_syste	0.76482947
60	MP0002229_neurodegeneration	0.75670004
61	MP0003880_abnormal_central_pattern	0.75231519
62	MP0001905_abnormal_dopamine_level	0.73981007
63	MP0008569_lethality_at_weaning	0.73791612
64	MP0000470_abnormal_stomach_morphology	0.73191374
65	MP0004085_abnormal_heartbeat	0.72478395
66	MP0001970_abnormal_pain_threshold	0.72374673
67	MP0005084_abnormal_gallbladder_morpholo	0.71515212
68	MP0001293_anophthalmia	0.71307905
69	MP0002272_abnormal_nervous_system	0.70355346
70	MP0001440_abnormal_grooming_behavior	0.69743629
71	MP0005253_abnormal_eye_physiology	0.67569419
72	MP0003119_abnormal_digestive_system	0.67105424
73	MP0005666_abnormal_adipose_tissue	0.65524060
74	MP0008995_early_reproductive_senescence	0.65361875
75	MP0005167_abnormal_blood-brain_barrier	0.63870153
76	MP0008961_abnormal_basal_metabolism	0.62835202
77	MP0002734_abnormal_mechanical_nocicepti	0.62692232
78	MP0006276_abnormal_autonomic_nervous	0.62376527
79	MP0005636_abnormal_mineral_homeostasis	0.62271822
80	MP0001879_abnormal_lymphatic_vessel	0.61288002
81	MP0003635_abnormal_synaptic_transmissio	0.60667235
82	MP0001984_abnormal_olfaction	0.59791957
83	MP0001666_abnormal_nutrient_absorption	0.57742531
84	MP0002928_abnormal_bile_duct	0.57176225
85	MP0002254_reproductive_system_inflammat	0.54439154
86	MP0000613_abnormal_salivary_gland	0.53882554
87	MP0003942_abnormal_urinary_system	0.52387146
88	MP0005535_abnormal_body_temperature	0.51444326
89	MP0000427_abnormal_hair_cycle	0.50516009
90	MP0005391_vision/eye_phenotype	0.49605435
91	MP0001529_abnormal_vocalization	0.48338222
92	MP0000372_irregular_coat_pigmentation	0.48273765
93	MP0005375_adipose_tissue_phenotype	0.46447373
94	MP0002882_abnormal_neuron_morphology	0.45436390
95	MP0002064_seizures	0.45329016
96	MP0002752_abnormal_somatic_nervous	0.43419116
97	MP0005195_abnormal_posterior_eye	0.43381003
98	MP0005647_abnormal_sex_gland	0.42721315
99	MP0004142_abnormal_muscle_tone	0.41345664
100	MP0002063_abnormal_learning/memory/cond	0.41330091

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.01714224
2	Absent/shortened dynein arms (HP:0200106)	5.74607666
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.74607666
4	Abnormal respiratory motile cilium morphology (HP:0005938)	5.34512680
5	Abnormal respiratory epithelium morphology (HP:0012253)	5.34512680
6	Abnormal ciliary motility (HP:0012262)	5.29723860
7	Abnormal respiratory motile cilium physiology (HP:0012261)	4.76452896
8	Attenuation of retinal blood vessels (HP:0007843)	4.74236629
9	Bony spicule pigmentary retinopathy (HP:0007737)	4.66072001
10	Asymmetric septal hypertrophy (HP:0001670)	4.32923541
11	Hypoplastic ischia (HP:0003175)	3.99513790
12	Abnormality of macular pigmentation (HP:0008002)	3.98413144
13	Infertility (HP:0000789)	3.94468452
14	Abnormal rod and cone electroretinograms (HP:0008323)	3.92354964
15	Bell-shaped thorax (HP:0001591)	3.85652760
16	Resting tremor (HP:0002322)	3.82955559
17	Enlarged epiphyses (HP:0010580)	3.77186354
18	Hyperkalemia (HP:0002153)	3.73122688
19	Generalized aminoaciduria (HP:0002909)	3.70661679
20	Chronic hepatic failure (HP:0100626)	3.59812974
21	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.58025082
22	Potter facies (HP:0002009)	3.57880914
23	Facial shape deformation (HP:0011334)	3.57880914
24	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.53325910
25	Nasal polyposis (HP:0100582)	3.50294043
26	Abnormality of the ischium (HP:0003174)	3.47556847
27	Male infertility (HP:0003251)	3.41945672
28	Cone-rod dystrophy (HP:0000548)	3.34146954
29	Tubulointerstitial nephritis (HP:0001970)	3.26834181
30	Impulsivity (HP:0100710)	3.24728200
31	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.20596484
32	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.09105319
33	Nephronophthisis (HP:0000090)	3.00160673
34	Occipital encephalocele (HP:0002085)	2.97315504
35	Unilateral renal agenesis (HP:0000122)	2.94466510
36	Renal dysplasia (HP:0000110)	2.93715530
37	Abnormal spermatogenesis (HP:0008669)	2.91848130
38	Rhinitis (HP:0012384)	2.89521381
39	Azoospermia (HP:0000027)	2.87693746
40	Double outlet right ventricle (HP:0001719)	2.79803878
41	Congenital malformation of the right heart (HP:0011723)	2.79803878
42	Abnormality of the nasal mucosa (HP:0000433)	2.70804183
43	Myokymia (HP:0002411)	2.62222273
44	Type II lissencephaly (HP:0007260)	2.50833457
45	Optic nerve hypoplasia (HP:0000609)	2.49916726
46	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.49809017
47	Pancreatic fibrosis (HP:0100732)	2.49341581
48	Abnormality of the renal medulla (HP:0100957)	2.47022683
49	Amelogenesis imperfecta (HP:0000705)	2.44059460
50	Abnormal urine output (HP:0012590)	2.42639271
51	Abnormality of the pubic bones (HP:0003172)	2.37317323
52	Progressive cerebellar ataxia (HP:0002073)	2.31714057
53	Abnormality of potassium homeostasis (HP:0011042)	2.29023434
54	Postural instability (HP:0002172)	2.28795131
55	Abnormality of the aortic arch (HP:0012303)	2.28753068
56	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.24043231
57	Absent epiphyses (HP:0010577)	2.24043231
58	Hypoplasia of the thymus (HP:0000778)	2.19770795
59	Pendular nystagmus (HP:0012043)	2.19391737
60	Stage 5 chronic kidney disease (HP:0003774)	2.17396601
61	Bronchiectasis (HP:0002110)	2.16786438
62	Decreased central vision (HP:0007663)	2.16225423
63	Sclerocornea (HP:0000647)	2.15980255
64	Abnormality of the costochondral junction (HP:0000919)	2.14767016
65	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.13069790
66	Abnormality of dental color (HP:0011073)	2.12442380
67	Abnormal drinking behavior (HP:0030082)	2.12361790
68	Polydipsia (HP:0001959)	2.12361790
69	True hermaphroditism (HP:0010459)	2.10734871
70	Hypoplastic left heart (HP:0004383)	2.10282765
71	Bulbous nose (HP:0000414)	2.09917846
72	Abnormality of renal excretion (HP:0011036)	2.08737425
73	Hypoplastic heart (HP:0001961)	2.03318082
74	Epiphyseal dysplasia (HP:0002656)	2.02876159
75	Glycosuria (HP:0003076)	2.01815066
76	Abnormality of urine glucose concentration (HP:0011016)	2.01815066
77	Recurrent corneal erosions (HP:0000495)	2.00620904
78	Anencephaly (HP:0002323)	2.00365850
79	Pancreatic cysts (HP:0001737)	1.98150633
80	Abnormality of the parathyroid morphology (HP:0011766)	1.97540369
81	Esophageal atresia (HP:0002032)	1.97439626
82	Polyuria (HP:0000103)	1.95210770
83	Anterior segment dysgenesis (HP:0007700)	1.94016235
84	Vertebral clefting (HP:0008428)	1.93411716
85	Renal Fanconi syndrome (HP:0001994)	1.93222434
86	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.91265631
87	Retinal dysplasia (HP:0007973)	1.90950447
88	Hypophosphatemic rickets (HP:0004912)	1.90689607
89	Osteomalacia (HP:0002749)	1.86011821
90	Chronic bronchitis (HP:0004469)	1.84681086
91	Intellectual disability, moderate (HP:0002342)	1.83516903
92	Portal hypertension (HP:0001409)	1.83471050
93	Truncal obesity (HP:0001956)	1.83165072
94	Congenital sensorineural hearing impairment (HP:0008527)	1.82753238
95	Cerebellar dysplasia (HP:0007033)	1.81228186
96	Abnormal ventriculo-arterial connection (HP:0011563)	1.80104359
97	Transposition of the great arteries (HP:0001669)	1.80104359
98	Abnormal connection of the cardiac segments (HP:0011545)	1.80104359
99	Upper limb muscle weakness (HP:0003484)	1.79740551
100	Respiratory distress (HP:0002098)	1.79692617

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.62794624
2	TESK1	5.38703319
3	DDR2	5.23773490
4	PNCK	3.53637142
5	INSRR	3.39845664
6	MAPK15	3.24963583
7	MAP4K2	3.24705373
8	STK38	2.79859230
9	PLK2	2.63715349
10	BRD4	2.31051442
11	CAMK1G	2.02319099
12	WNK1	1.90267406
13	WNK4	1.74355470
14	PRKD3	1.60107712
15	STK38L	1.58238196
16	PDPK1	1.52358435
17	PDK1	1.41200421
18	PIK3CG	1.39187595
19	MAP3K9	1.31991819
20	CDK7	1.31434962
21	DYRK1B	1.28741070
22	MST1R	1.22191268
23	UHMK1	1.11840714
24	ZAK	1.11473875
25	PTK2B	1.09442790
26	CAMK1D	1.08146418
27	BMPR1B	1.02173543
28	KSR2	0.97596771
29	STK39	0.88017726
30	MUSK	0.85112178
31	CDK12	0.83881594
32	LATS2	0.81640076
33	TYRO3	0.80478106
34	MAP2K2	0.80380502
35	NEK6	0.80270003
36	MAP3K11	0.79515855
37	RPS6KA2	0.76549772
38	SIK2	0.74502508
39	PRKCG	0.72260171
40	ADRBK2	0.69264740
41	PRKG1	0.68991561
42	NTRK3	0.67489766
43	BRAF	0.66898591
44	PRKG2	0.65358887
45	RPS6KA1	0.64416810
46	RPS6KA6	0.64059216
47	MAP3K4	0.62528748
48	MARK1	0.58734875
49	EPHB2	0.58650665
50	CAMK1	0.58535069
51	DYRK3	0.55820801
52	DYRK2	0.55553424
53	CDK3	0.53057479
54	CDK19	0.49931497
55	AKT3	0.48372426
56	PRKAA2	0.46509005
57	GSK3B	0.46300877
58	RPS6KL1	0.46084719
59	RPS6KC1	0.46084719
60	MAPK8	0.45032361
61	OXSR1	0.43765557
62	TGFBR1	0.43653653
63	WNK3	0.43649573
64	ACVR1B	0.42591425
65	CDK1	0.42531827
66	PKN1	0.40228821
67	CDK2	0.40073385
68	ARAF	0.38150956
69	FRK	0.38017163
70	MAP3K2	0.37673501
71	SGK494	0.37247365
72	SGK223	0.37247365
73	CAMK4	0.37136675
74	CDK4	0.37059424
75	MAPK1	0.36601457
76	PRKCZ	0.35481665
77	FGFR2	0.34589083
78	MAP3K8	0.34199468
79	ROCK1	0.33133073
80	MAP2K7	0.33020425
81	NEK2	0.32445238
82	SGK1	0.30037378
83	PASK	0.29386105
84	MAP3K1	0.27226161
85	PRKACB	0.26811470
86	CHEK1	0.25915626
87	TIE1	0.25252874
88	NUAK1	0.24333078
89	PRKACA	0.23756606
90	PRKCB	0.23330954
91	AKT1	0.23205692
92	GRK1	0.21810212
93	MAPK14	0.21747520
94	IKBKB	0.21583438
95	AURKA	0.21429861
96	MAP2K4	0.19611806
97	RIPK4	0.19077536
98	TXK	0.18692872
99	STK11	0.17829426
100	BRSK1	0.16353313

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.33028593
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.96858382
3	Olfactory transduction_Homo sapiens_hsa04740	3.62906575
4	Butanoate metabolism_Homo sapiens_hsa00650	2.66237559
5	Taste transduction_Homo sapiens_hsa04742	2.15626863
6	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.98372446
7	Cardiac muscle contraction_Homo sapiens_hsa04260	1.78406096
8	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.77977318
9	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.70027744
10	Nicotine addiction_Homo sapiens_hsa05033	1.69113093
11	Morphine addiction_Homo sapiens_hsa05032	1.50666031
12	Fatty acid degradation_Homo sapiens_hsa00071	1.43726660
13	Phototransduction_Homo sapiens_hsa04744	1.41386536
14	Renin-angiotensin system_Homo sapiens_hsa04614	1.36879999
15	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.34390707
16	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.33249499
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.32786420
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.31498306
19	Allograft rejection_Homo sapiens_hsa05330	1.31378012
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.30943205
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.29069938
22	Type I diabetes mellitus_Homo sapiens_hsa04940	1.28558741
23	Graft-versus-host disease_Homo sapiens_hsa05332	1.25994840
24	Type II diabetes mellitus_Homo sapiens_hsa04930	1.25917718
25	Fatty acid metabolism_Homo sapiens_hsa01212	1.25887500
26	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.24942384
27	Antigen processing and presentation_Homo sapiens_hsa04612	1.24602490
28	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.21725810
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.13804631
30	Calcium signaling pathway_Homo sapiens_hsa04020	1.11651717
31	Circadian entrainment_Homo sapiens_hsa04713	1.10664180
32	Protein digestion and absorption_Homo sapiens_hsa04974	1.08423430
33	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.05140285
34	Fat digestion and absorption_Homo sapiens_hsa04975	1.04065747
35	RNA transport_Homo sapiens_hsa03013	0.98263983
36	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.97796244
37	Glutamatergic synapse_Homo sapiens_hsa04724	0.97480601
38	Arginine and proline metabolism_Homo sapiens_hsa00330	0.95281827
39	Cocaine addiction_Homo sapiens_hsa05030	0.94849061
40	Huntingtons disease_Homo sapiens_hsa05016	0.94039090
41	cAMP signaling pathway_Homo sapiens_hsa04024	0.93653177
42	Basal transcription factors_Homo sapiens_hsa03022	0.93105568
43	Retinol metabolism_Homo sapiens_hsa00830	0.91552677
44	Phenylalanine metabolism_Homo sapiens_hsa00360	0.90815119
45	PPAR signaling pathway_Homo sapiens_hsa03320	0.90739977
46	Salivary secretion_Homo sapiens_hsa04970	0.87866005
47	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.85596769
48	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85522757
49	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.85121795
50	Basal cell carcinoma_Homo sapiens_hsa05217	0.84458141
51	Caffeine metabolism_Homo sapiens_hsa00232	0.84233384
52	Ribosome_Homo sapiens_hsa03010	0.80622013
53	Linoleic acid metabolism_Homo sapiens_hsa00591	0.78825356
54	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.76641627
55	ABC transporters_Homo sapiens_hsa02010	0.76428543
56	Glycerolipid metabolism_Homo sapiens_hsa00561	0.75289946
57	Serotonergic synapse_Homo sapiens_hsa04726	0.74984071
58	Cholinergic synapse_Homo sapiens_hsa04725	0.70541777
59	GABAergic synapse_Homo sapiens_hsa04727	0.70537145
60	Alcoholism_Homo sapiens_hsa05034	0.69695075
61	Insulin secretion_Homo sapiens_hsa04911	0.68984745
62	Oocyte meiosis_Homo sapiens_hsa04114	0.68205850
63	Bile secretion_Homo sapiens_hsa04976	0.67988807
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.66789136
65	Amphetamine addiction_Homo sapiens_hsa05031	0.63870553
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.62667269
67	Estrogen signaling pathway_Homo sapiens_hsa04915	0.57840873
68	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.57080172
69	Endocytosis_Homo sapiens_hsa04144	0.56023058
70	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.54401216
71	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.54203070
72	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.53869774
73	Fanconi anemia pathway_Homo sapiens_hsa03460	0.52332632
74	Viral myocarditis_Homo sapiens_hsa05416	0.51676678
75	Renin secretion_Homo sapiens_hsa04924	0.51024207
76	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50890449
77	Purine metabolism_Homo sapiens_hsa00230	0.50403529
78	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.50306334
79	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.49694655
80	Hippo signaling pathway_Homo sapiens_hsa04390	0.48915158
81	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.48346153
82	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.47843867
83	MAPK signaling pathway_Homo sapiens_hsa04010	0.44157737
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44104647
85	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.43338569
86	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.43309016
87	Gastric acid secretion_Homo sapiens_hsa04971	0.43179685
88	Tyrosine metabolism_Homo sapiens_hsa00350	0.42482652
89	Arginine biosynthesis_Homo sapiens_hsa00220	0.41483211
90	Nitrogen metabolism_Homo sapiens_hsa00910	0.40752909
91	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.39740035
92	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.39693761
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.38361500
94	Viral carcinogenesis_Homo sapiens_hsa05203	0.37331298
95	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.37207350
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.36904970
97	Tryptophan metabolism_Homo sapiens_hsa00380	0.36603669
98	Notch signaling pathway_Homo sapiens_hsa04330	0.30462755
99	Sulfur relay system_Homo sapiens_hsa04122	0.29137758
100	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.25652534

TBC1D3P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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