TBC1D4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1growth hormone receptor signaling pathway (GO:0060396)6.57846916
2antigen processing and presentation of endogenous antigen (GO:0019883)6.39903796
3muscle filament sliding (GO:0030049)5.90414851
4actin-myosin filament sliding (GO:0033275)5.90414851
5positive regulation of cell size (GO:0045793)5.77287834
6myeloid dendritic cell differentiation (GO:0043011)5.69878651
7cellular response to growth hormone stimulus (GO:0071378)5.69407695
8regulation of interleukin-12 biosynthetic process (GO:0045075)5.60722400
9regulation of RIG-I signaling pathway (GO:0039535)5.55389054
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.46594800
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.46594800
12regulation of dendritic cell antigen processing and presentation (GO:0002604)5.38215071
13necroptotic process (GO:0070266)5.23801587
14negative regulation of necroptotic process (GO:0060546)5.19750889
15regulation of necroptotic process (GO:0060544)5.19071878
16negative thymic T cell selection (GO:0045060)5.18221112
17myeloid dendritic cell activation (GO:0001773)5.11219005
18CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)5.04938633
19T-helper cell differentiation (GO:0042093)5.04938633
20natural killer cell mediated immunity (GO:0002228)4.99677959
21natural killer cell mediated cytotoxicity (GO:0042267)4.99677959
22sarcoplasmic reticulum calcium ion transport (GO:0070296)4.99556249
23actin-mediated cell contraction (GO:0070252)4.86732446
24negative T cell selection (GO:0043383)4.81999630
25dendritic cell differentiation (GO:0097028)4.72023123
26myofibril assembly (GO:0030239)4.69094336
27regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.66475581
28regulation of T cell tolerance induction (GO:0002664)4.61990771
29response to muramyl dipeptide (GO:0032495)4.60954896
30sarcomere organization (GO:0045214)4.54331124
31glucocorticoid biosynthetic process (GO:0006704)4.48357376
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.40975029
33positive regulation of natural killer cell differentiation (GO:0032825)4.40521391
34positive regulation of antigen processing and presentation (GO:0002579)4.38445406
35interferon-gamma secretion (GO:0072643)4.37715396
36nuclear pore complex assembly (GO:0051292)4.36475395
37T cell differentiation involved in immune response (GO:0002292)4.32827964
38alpha-beta T cell differentiation involved in immune response (GO:0002293)4.32827964
39alpha-beta T cell activation involved in immune response (GO:0002287)4.32827964
40response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.22949363
41positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.17971794
42positive regulation of gamma-delta T cell activation (GO:0046645)4.16778019
43skeletal muscle contraction (GO:0003009)4.15302545
44actin filament-based movement (GO:0030048)4.14611507
45cardiac myofibril assembly (GO:0055003)4.10324103
46negative regulation of necrotic cell death (GO:0060547)4.05271203
47regulation of relaxation of muscle (GO:1901077)3.97653759
48creatine metabolic process (GO:0006600)3.91045254
49programmed necrotic cell death (GO:0097300)3.90221516
50mature B cell differentiation (GO:0002335)3.89830730
51positive regulation of interleukin-2 production (GO:0032743)3.86888210
52striated muscle contraction (GO:0006941)3.78233598
53necrotic cell death (GO:0070265)3.77828713
54response to prostaglandin E (GO:0034695)3.76315097
55regulation of antigen processing and presentation (GO:0002577)3.75381875
56JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.75175450
57glucocorticoid metabolic process (GO:0008211)3.73763709
58cardiac muscle hypertrophy (GO:0003300)3.71156690
59cardiac muscle contraction (GO:0060048)3.70299947
60negative regulation of cell killing (GO:0031342)3.68692674
61negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.68692674
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.66983316
63T cell migration (GO:0072678)3.66816472
64positive regulation of protein oligomerization (GO:0032461)3.63837154
65positive regulation of T cell cytokine production (GO:0002726)3.63181500
66striated muscle hypertrophy (GO:0014897)3.63173688
67regulation of hypersensitivity (GO:0002883)3.62658919
68regulation of T-helper 1 cell differentiation (GO:0045625)3.60058338
69NADH metabolic process (GO:0006734)3.58396997
70neutrophil activation (GO:0042119)3.57705179
71positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.55095426
72nuclear pore organization (GO:0006999)3.54929953
73negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.54861508
74thymic T cell selection (GO:0045061)3.54209372
75actomyosin structure organization (GO:0031032)3.49403120
76positive regulation of natural killer cell mediated immunity (GO:0002717)3.45157897
77lymphocyte migration (GO:0072676)3.44693523
78regulation of MHC class I biosynthetic process (GO:0045343)3.43188593
79positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.42081927
80cellular response to epinephrine stimulus (GO:0071872)3.41617101
81regulation of tolerance induction (GO:0002643)3.41289944
82positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.41028747
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40615018
84neutrophil activation involved in immune response (GO:0002283)3.38617328
85positive regulation of interleukin-12 production (GO:0032735)3.36590138
86granulocyte activation (GO:0036230)3.35734176
87positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.33888484
88regulation of necrotic cell death (GO:0010939)3.32097850
89regulation of isotype switching to IgG isotypes (GO:0048302)3.26623410
90CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.26171113
91carnitine shuttle (GO:0006853)3.23566656
92positive regulation of humoral immune response (GO:0002922)3.23222015
93regulation of integrin activation (GO:0033623)3.23115790
94T cell selection (GO:0045058)3.18923608
95T cell activation involved in immune response (GO:0002286)3.18602442
96positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.17827108
97regulation of actin filament-based movement (GO:1903115)3.17543136
98response to mercury ion (GO:0046689)3.16405267
99muscle hypertrophy (GO:0014896)3.15741279
100regulation of skeletal muscle contraction (GO:0014819)3.15262196
101fatty acid homeostasis (GO:0055089)3.13495124
102regulation of gamma-delta T cell differentiation (GO:0045586)3.13024307
103glycogen catabolic process (GO:0005980)3.12675071
104positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.12339882
105interferon-gamma-mediated signaling pathway (GO:0060333)3.09166514
106leukocyte mediated cytotoxicity (GO:0001909)3.08782602
107regulation of response to interferon-gamma (GO:0060330)3.07027302
108negative regulation of innate immune response (GO:0045824)3.06585589
109negative regulation of potassium ion transmembrane transport (GO:1901380)3.04957899
110response to muscle activity (GO:0014850)3.03894993
111response to interleukin-15 (GO:0070672)3.03806804
112cardiac muscle tissue morphogenesis (GO:0055008)3.02355964
113striated muscle adaptation (GO:0014888)3.02243912
114regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.00470873
115regulation of cellular extravasation (GO:0002691)2.99428494
116response to epinephrine (GO:0071871)2.99141760
117regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.97511197
118cellular response to antibiotic (GO:0071236)2.97392693
119CD4-positive, alpha-beta T cell activation (GO:0035710)2.97221696
120positive regulation of interleukin-17 production (GO:0032740)2.97142431
121positive thymic T cell selection (GO:0045059)2.96897298
122positive regulation of p38MAPK cascade (GO:1900745)2.96097557
123regulation of protein polyubiquitination (GO:1902914)2.95882625
124regulation of protein oligomerization (GO:0032459)2.94097706
125pore complex assembly (GO:0046931)2.92370888
126regulation of gamma-delta T cell activation (GO:0046643)2.91719972
127glucan catabolic process (GO:0009251)2.91662259
128T cell mediated immunity (GO:0002456)2.88968401
129regulation of histone H3-K27 methylation (GO:0061085)2.87017015
130regulation of interleukin-12 production (GO:0032655)2.85558259
131regulation of natural killer cell mediated immunity (GO:0002715)2.84503048
132regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.84503048
133positive regulation of tolerance induction (GO:0002645)2.83310383
134germinal center formation (GO:0002467)2.83165895
135positive regulation of B cell differentiation (GO:0045579)2.83094787
136muscle tissue morphogenesis (GO:0060415)2.82122704
137negative regulation of alpha-beta T cell activation (GO:0046636)2.80753245
138muscle contraction (GO:0006936)2.79644319
139cardiac muscle hypertrophy in response to stress (GO:0014898)2.79096167
140muscle hypertrophy in response to stress (GO:0003299)2.79096167
141cardiac muscle adaptation (GO:0014887)2.79096167
142embryonic process involved in female pregnancy (GO:0060136)2.77776259
143histone H3-K36 demethylation (GO:0070544)2.77206722
144regulation of natural killer cell differentiation (GO:0032823)2.77164204
145regulation of B cell differentiation (GO:0045577)2.76722758
146adult heart development (GO:0007512)2.76396959
147cellular polysaccharide catabolic process (GO:0044247)2.75823388
148cellular response to interleukin-15 (GO:0071350)2.75303451
149positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.75163427
150regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.74689066
151regulation of cholesterol homeostasis (GO:2000188)2.74172487
152regulation of regulatory T cell differentiation (GO:0045589)2.73701249
153skeletal muscle adaptation (GO:0043501)2.73610674
154negative regulation of erythrocyte differentiation (GO:0045647)2.72999150
155regulation of T cell receptor signaling pathway (GO:0050856)2.72584168
156T cell homeostasis (GO:0043029)2.72065533
157antigen processing and presentation via MHC class Ib (GO:0002475)2.70637712
158positive T cell selection (GO:0043368)2.70488626
159striated muscle atrophy (GO:0014891)2.70457313
160regulation of interleukin-2 production (GO:0032663)2.69932431
161cytokine secretion (GO:0050663)2.69070232
162low-density lipoprotein particle clearance (GO:0034383)2.64403104
163fatty acid transmembrane transport (GO:1902001)2.64071542
164negative regulation of T cell mediated immunity (GO:0002710)2.62992439
165ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.60460124
166cellular hyperosmotic response (GO:0071474)2.60263601
167regulation of interleukin-2 biosynthetic process (GO:0045076)2.59592372
168tricarboxylic acid metabolic process (GO:0072350)2.58034930
169C21-steroid hormone metabolic process (GO:0008207)2.57696178
170response to inactivity (GO:0014854)2.54785931
171succinate metabolic process (GO:0006105)2.53038754
172CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.53017931
173C21-steroid hormone biosynthetic process (GO:0006700)2.52608033
174oxaloacetate metabolic process (GO:0006107)2.51223544
175regulation of NFAT protein import into nucleus (GO:0051532)2.50031371
176regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.49461172
177positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.49226535
178muscle system process (GO:0003012)2.48677202
1792-oxoglutarate metabolic process (GO:0006103)2.48569722
180NIK/NF-kappaB signaling (GO:0038061)11.8405582

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.87297750
2* IRF8_22096565_ChIP-ChIP_GC-B_Human4.16005563
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.01182450
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.67679148
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.62731897
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.54023244
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.46272980
8SMAD_19615063_ChIP-ChIP_OVARY_Human3.39688703
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.25768779
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.25273229
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.19396847
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.17489916
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.15547837
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.90555688
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.81505318
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.73437090
17E2F7_22180533_ChIP-Seq_HELA_Human2.73280256
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.60738440
19GATA1_22025678_ChIP-Seq_K562_Human2.56033612
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46647505
21* RUNX_20019798_ChIP-Seq_JUKART_Human2.40052455
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.25130644
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.19684540
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18437888
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.17547483
26MAF_26560356_Chip-Seq_TH1_Human2.17436546
27VDR_24787735_ChIP-Seq_THP-1_Human2.14833884
28MYB_21317192_ChIP-Seq_ERMYB_Mouse2.12956731
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.09390317
30STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05298191
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03890762
32MYB_26560356_Chip-Seq_TH2_Human1.99823136
33TCF7_22412390_ChIP-Seq_EML_Mouse1.98746210
34NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.95401603
35NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.94322800
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91935359
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.81945055
38ZNF263_19887448_ChIP-Seq_K562_Human1.79945050
39VDR_21846776_ChIP-Seq_THP-1_Human1.75899208
40CLOCK_20551151_ChIP-Seq_293T_Human1.75702535
41KDM2B_26808549_Chip-Seq_DND41_Human1.73541942
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70466742
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68106648
44GATA3_27048872_Chip-Seq_THYMUS_Human1.65069521
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64513697
46VDR_24763502_ChIP-Seq_THP-1_Human1.62029601
47MYB_26560356_Chip-Seq_TH1_Human1.61273392
48FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.59867617
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59793280
50* FOXA2_19822575_ChIP-Seq_HepG2_Human1.59750363
51ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58427517
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.57657186
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.56160672
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51776263
55TBX20_22080862_ChIP-Seq_HEART_Mouse1.49684747
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.49684747
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48371027
58RXR_22158963_ChIP-Seq_LIVER_Mouse1.44296687
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43470953
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.39891045
61GATA4_21415370_ChIP-Seq_HL-1_Mouse1.38524551
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37902655
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37007306
64MYC_22102868_ChIP-Seq_BL_Human1.35853886
65SPI1_23127762_ChIP-Seq_K562_Human1.35513636
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33302872
67* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28531708
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28374005
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27119227
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26903999
71MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.25991314
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.24372132
73SCL_19346495_ChIP-Seq_HPC-7_Human1.24343166
74SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24040939
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.20707329
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19149794
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.15600852
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15326073
79MAF_26560356_Chip-Seq_TH2_Human1.15134736
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.15094575
81UTX_26944678_Chip-Seq_JUKART_Human1.15042624
82SMRT_27268052_Chip-Seq_Bcells_Human1.14823710
83PU_27001747_Chip-Seq_BMDM_Mouse1.14778198
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14703500
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.14647968
86AR_21909140_ChIP-Seq_LNCAP_Human1.14632133
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13686088
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13095113
89CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12076848
90* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09666974
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09521851
92GATA3_26560356_Chip-Seq_TH2_Human1.09262431
93GATA1_19941826_ChIP-Seq_K562_Human1.07815794
94CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07315600
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07180786
96* SPI1_23547873_ChIP-Seq_NB4_Human1.06794029
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04454335
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03970718
99GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03626198
100WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02720074
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01940946
102EP300_21415370_ChIP-Seq_HL-1_Mouse1.01102292
103PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01069103
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00809287
105KDM2B_26808549_Chip-Seq_K562_Human0.99542981
106* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98755160
107SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98194913
108SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98194913
109RUNX1_22412390_ChIP-Seq_EML_Mouse0.97013361
110* CHD1_26751641_Chip-Seq_LNCaP_Human0.95947920
111ESR2_21235772_ChIP-Seq_MCF-7_Human0.95907249
112TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95335566
113SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94386979
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.93886519
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93370085
116EGR1_19032775_ChIP-ChIP_M12_Human0.93289078
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92538579
118SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91305130
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.90219981
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.89175680
121* GATA6_25053715_ChIP-Seq_YYC3_Human0.89012785
122* RACK7_27058665_Chip-Seq_MCF-7_Human0.88812074
123NOTCH1_21737748_ChIP-Seq_TLL_Human0.88626265
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87805562
125UBF1/2_26484160_Chip-Seq_HMECs_Human0.87667874
126AR_21572438_ChIP-Seq_LNCaP_Human0.86160528
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85717272
128KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85627435
129RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85501881
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85393260
131IGF1R_20145208_ChIP-Seq_DFB_Human0.82107337
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81824812
133RXR_22108803_ChIP-Seq_LS180_Human0.81442943
134CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.81282570
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79880471
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79880471
137GATA2_19941826_ChIP-Seq_K562_Human0.79836812
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79068856
139STAT6_21828071_ChIP-Seq_BEAS2B_Human0.78446684
140DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.76973524
141EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.75186860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system6.24256292
2MP0002254_reproductive_system_inflammat5.98153734
3MP0004510_myositis5.05279816
4MP0002009_preneoplasia4.52795843
5MP0002166_altered_tumor_susceptibility3.98105077
6MP0001835_abnormal_antigen_presentation3.77060863
7MP0000751_myopathy3.56612753
8MP0004145_abnormal_muscle_electrophysio3.33157280
9MP0005451_abnormal_body_composition3.27084559
10MP0000685_abnormal_immune_system3.16623818
11MP0001348_abnormal_lacrimal_gland3.13326567
12MP0002877_abnormal_melanocyte_morpholog3.05394480
13MP0002006_tumorigenesis3.01872998
14MP0000749_muscle_degeneration2.91569120
15MP0000569_abnormal_digit_pigmentation2.80338963
16MP0001873_stomach_inflammation2.49241662
17MP0005387_immune_system_phenotype2.35711941
18MP0001790_abnormal_immune_system2.35711941
19MP0002269_muscular_atrophy2.28212673
20MP0001661_extended_life_span2.26320940
21MP0005310_abnormal_salivary_gland2.26157236
22MP0002148_abnormal_hypersensitivity_rea2.22079835
23MP0001800_abnormal_humoral_immune2.21553797
24MP0000759_abnormal_skeletal_muscle2.07270927
25MP0003436_decreased_susceptibility_to2.05635999
26MP0002163_abnormal_gland_morphology2.04708975
27MP0002452_abnormal_antigen_presenting1.99621977
28MP0005000_abnormal_immune_tolerance1.99528763
29MP0000747_muscle_weakness1.97608843
30MP0004233_abnormal_muscle_weight1.96876276
31MP0005671_abnormal_response_to1.95426254
32MP0001853_heart_inflammation1.93260424
33MP0010368_abnormal_lymphatic_system1.93199847
34MP0002723_abnormal_immune_serum1.87725894
35MP0005369_muscle_phenotype1.86828234
36MP0001819_abnormal_immune_cell1.82908759
37MP0002420_abnormal_adaptive_immunity1.80805650
38MP0010352_gastrointestinal_tract_polyps1.68877650
39MP0002277_abnormal_respiratory_mucosa1.68451969
40MP0005620_abnormal_muscle_contractility1.64988134
41MP0003221_abnormal_cardiomyocyte_apopto1.64386912
42MP0002419_abnormal_innate_immunity1.63746668
43MP0000013_abnormal_adipose_tissue1.57026215
44MP0002332_abnormal_exercise_endurance1.54555120
45MP0001346_abnormal_lacrimal_gland1.51789738
46MP0009785_altered_susceptibility_to1.48615808
47MP0004484_altered_response_of1.46500095
48MP0000716_abnormal_immune_system1.45384327
49MP0005025_abnormal_response_to1.45108730
50MP0003763_abnormal_thymus_physiology1.44812666
51MP0005375_adipose_tissue_phenotype1.43158293
52MP0004947_skin_inflammation1.42723048
53MP0002398_abnormal_bone_marrow1.42006067
54MP0003300_gastrointestinal_ulcer1.41629628
55MP0000003_abnormal_adipose_tissue1.40709021
56MP0002396_abnormal_hematopoietic_system1.40436619
57MP0001879_abnormal_lymphatic_vessel1.37692361
58MP0004381_abnormal_hair_follicle1.33227433
59MP0003091_abnormal_cell_migration1.32536486
60MP0003303_peritoneal_inflammation1.29798121
61MP0002837_dystrophic_cardiac_calcinosis1.27819052
62MP0008004_abnormal_stomach_pH1.27183871
63MP0004084_abnormal_cardiac_muscle1.24238979
64MP0002127_abnormal_cardiovascular_syste1.21736257
65MP0002405_respiratory_system_inflammati1.20304935
66MP0003828_pulmonary_edema1.16782719
67MP0010155_abnormal_intestine_physiology1.13700723
68MP0002429_abnormal_blood_cell1.12363150
69MP0009333_abnormal_splenocyte_physiolog1.12308429
70MP0003705_abnormal_hypodermis_morpholog1.11283569
71MP0008775_abnormal_heart_ventricle1.09510350
72MP0003453_abnormal_keratinocyte_physiol1.07894281
73MP0003868_abnormal_feces_composition1.05409083
74MP0002933_joint_inflammation1.03652158
75MP0002108_abnormal_muscle_morphology0.99741258
76MP0002722_abnormal_immune_system0.99580282
77MP0005076_abnormal_cell_differentiation0.99334029
78MP0000703_abnormal_thymus_morphology0.98009605
79MP0000750_abnormal_muscle_regeneration0.96307020
80MP0000689_abnormal_spleen_morphology0.95136472
81MP0006138_congestive_heart_failure0.93973543
82MP0003448_altered_tumor_morphology0.92987546
83MP0003984_embryonic_growth_retardation0.91772034
84MP0001845_abnormal_inflammatory_respons0.91696868
85MP0010630_abnormal_cardiac_muscle0.91506264
86MP0002088_abnormal_embryonic_growth/wei0.91160943
87MP0001915_intracranial_hemorrhage0.90967041
88MP0000604_amyloidosis0.90954327
89MP0006036_abnormal_mitochondrial_physio0.88836932
90MP0004130_abnormal_muscle_cell0.88792860
91MP0005379_endocrine/exocrine_gland_phen0.88596059
92MP0005670_abnormal_white_adipose0.88181546
93MP0003950_abnormal_plasma_membrane0.88149130
94MP0003866_abnormal_defecation0.84848152
95MP0005666_abnormal_adipose_tissue0.82696711
96MP0004087_abnormal_muscle_fiber0.81736803
97MP0003045_fibrosis0.81193793
98MP0003567_abnormal_fetal_cardiomyocyte0.80707301
99MP0000767_abnormal_smooth_muscle0.80318707
100MP0002998_abnormal_bone_remodeling0.80001656
101MP0005266_abnormal_metabolism0.79733397
102MP0001881_abnormal_mammary_gland0.79732866
103MP0005174_abnormal_tail_pigmentation0.79567025
104MP0001730_embryonic_growth_arrest0.78361432
105MP0008469_abnormal_protein_level0.77984850
106MP0000371_diluted_coat_color0.77845949
107MP0001533_abnormal_skeleton_physiology0.77666689
108MP0004185_abnormal_adipocyte_glucose0.77426819
109MP0000266_abnormal_heart_morphology0.77130293
110MP0009764_decreased_sensitivity_to0.76840181
111MP0004808_abnormal_hematopoietic_stem0.76493024
112MP0008872_abnormal_physiological_respon0.75282306
113MP0002128_abnormal_blood_circulation0.73643945
114MP0004036_abnormal_muscle_relaxation0.70452110
115MP0000733_abnormal_muscle_development0.70310350
116MP0009840_abnormal_foam_cell0.69954672
117MP0008057_abnormal_DNA_replication0.69912591
118MP0005058_abnormal_lysosome_morphology0.68752214
119MP0000249_abnormal_blood_vessel0.68462452
120MP0005409_darkened_coat_color0.68431417
121MP0004272_abnormal_basement_membrane0.68135960
122MP0001851_eye_inflammation0.67785801
123MP0001243_abnormal_dermal_layer0.67674880
124MP0005385_cardiovascular_system_phenoty0.67503705
125MP0001544_abnormal_cardiovascular_syste0.67503705
126MP0001672_abnormal_embryogenesis/_devel0.67373127
127MP0005380_embryogenesis_phenotype0.67373127
128MP0001545_abnormal_hematopoietic_system0.67057925
129MP0005397_hematopoietic_system_phenotyp0.67057925
130MP0002972_abnormal_cardiac_muscle0.66067081
131MP0009115_abnormal_fat_cell0.65972709
132MP0005623_abnormal_meninges_morphology0.65630893
133MP0003646_muscle_fatigue0.65242424
134MP0001765_abnormal_ion_homeostasis0.64040013
135MP0002971_abnormal_brown_adipose0.63763171
136MP0002078_abnormal_glucose_homeostasis0.63373134
137MP0005464_abnormal_platelet_physiology0.61800911
138MP0002693_abnormal_pancreas_physiology0.61058040
139MP0003943_abnormal_hepatobiliary_system0.60846996
140MP0003566_abnormal_cell_adhesion0.60018605
141MP0002106_abnormal_muscle_physiology0.58551052
142MP0004215_abnormal_myocardial_fiber0.58047093
143MP0002295_abnormal_pulmonary_circulatio0.56078561
144MP0010234_abnormal_vibrissa_follicle0.53917343
145MP0002136_abnormal_kidney_physiology0.52092093
146MP0005330_cardiomyopathy0.50115348
147MP0003183_abnormal_peptide_metabolism0.49322491

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.93128348
2Nemaline bodies (HP:0003798)6.91732055
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.68153450
4Fatigue (HP:0012378)5.72001122
5Type 1 muscle fiber predominance (HP:0003803)5.06151232
6Recurrent viral infections (HP:0004429)5.05263767
7Recurrent fungal infections (HP:0002841)5.02919711
8Abnormality of the left ventricular outflow tract (HP:0011103)4.75671835
9Subaortic stenosis (HP:0001682)4.75671835
10Polycythemia (HP:0001901)4.50909719
11Hematochezia (HP:0002573)4.28173967
12Centrally nucleated skeletal muscle fibers (HP:0003687)4.26079696
13Myocardial infarction (HP:0001658)4.21934207
14Cortical dysplasia (HP:0002539)4.20543912
15EMG: myopathic abnormalities (HP:0003458)4.12549053
16Colitis (HP:0002583)4.08269290
17Increased IgE level (HP:0003212)4.04217576
18Thrombocytosis (HP:0001894)3.90996998
19Gastrointestinal infarctions (HP:0005244)3.84411300
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.82301698
21Eczematoid dermatitis (HP:0000976)3.78959171
22Recurrent bacterial skin infections (HP:0005406)3.77523127
23Cerebral hemorrhage (HP:0001342)3.76015001
24Pulmonary infiltrates (HP:0002113)3.71549538
25Rhabdomyolysis (HP:0003201)3.66688436
26Mediastinal lymphadenopathy (HP:0100721)3.62926966
27Chronic otitis media (HP:0000389)3.59862269
28Myopathic facies (HP:0002058)3.59836843
29Peritonitis (HP:0002586)3.55784279
30Recurrent abscess formation (HP:0002722)3.52371206
31Esophageal varix (HP:0002040)3.52076522
32Arterial thrombosis (HP:0004420)3.49650218
33Recurrent cutaneous fungal infections (HP:0011370)3.48846115
34Chronic mucocutaneous candidiasis (HP:0002728)3.48846115
35Nasal polyposis (HP:0100582)3.39815017
36Eosinophilia (HP:0001880)3.36854795
37Abnormality of skeletal muscle fiber size (HP:0012084)3.34930651
38Neck muscle weakness (HP:0000467)3.31496267
39Agammaglobulinemia (HP:0004432)3.29603563
40Muscle fiber splitting (HP:0003555)3.27442820
41Increased connective tissue (HP:0009025)3.27193039
42Abnormality of the fingertips (HP:0001211)3.25623915
43Dysmetric saccades (HP:0000641)3.20874824
44Asymmetric septal hypertrophy (HP:0001670)3.18844656
45Inflammation of the large intestine (HP:0002037)3.16380084
46Abnormality of the nasal mucosa (HP:0000433)3.14709945
47Panhypogammaglobulinemia (HP:0003139)3.13881672
48Bundle branch block (HP:0011710)3.13843242
49Distal arthrogryposis (HP:0005684)3.13090426
50Optic neuritis (HP:0100653)3.12294867
51Retrobulbar optic neuritis (HP:0100654)3.12294867
52Elevated erythrocyte sedimentation rate (HP:0003565)3.10072529
53Myositis (HP:0100614)3.06485849
54Periodontitis (HP:0000704)3.06116486
55Round ear (HP:0100830)3.05584176
56Abnormality of the calf musculature (HP:0001430)3.03899039
57Recurrent skin infections (HP:0001581)3.03611319
58Leukocytosis (HP:0001974)2.99894759
59Tinnitus (HP:0000360)2.96353751
60Granulocytopenia (HP:0001913)2.96250359
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.94856944
62Osteolytic defects of the hand bones (HP:0009699)2.94856944
63Increased variability in muscle fiber diameter (HP:0003557)2.92765710
64Gastrointestinal inflammation (HP:0004386)2.92043690
65Ulnar deviation of the wrist (HP:0003049)2.91665898
66Orchitis (HP:0100796)2.90341155
67Acute myeloid leukemia (HP:0004808)2.85468753
68Hyporeflexia of lower limbs (HP:0002600)2.80306275
69Sudden death (HP:0001699)2.77095067
70Frequent falls (HP:0002359)2.72478706
71Chest pain (HP:0100749)2.67969402
72Abnormality of the periventricular white matter (HP:0002518)2.64411910
73EMG: neuropathic changes (HP:0003445)2.61065138
74Persistence of primary teeth (HP:0006335)2.60412229
75Dilated cardiomyopathy (HP:0001644)2.59082160
76Abnormality of eosinophils (HP:0001879)2.57860249
77Right ventricular cardiomyopathy (HP:0011663)2.57532920
78Hypergammaglobulinemia (HP:0010702)2.52052130
79Distal lower limb muscle weakness (HP:0009053)2.48974857
80Muscle stiffness (HP:0003552)2.48347444
81Malignant hyperthermia (HP:0002047)2.43482125
82Areflexia of lower limbs (HP:0002522)2.43336486
83Rimmed vacuoles (HP:0003805)2.39790262
84Portal hypertension (HP:0001409)2.38981341
85Progressive muscle weakness (HP:0003323)2.37127033
86Generalized muscle weakness (HP:0003324)2.36927393
87Vasculitis (HP:0002633)2.36648336
88Pulmonary artery stenosis (HP:0004415)2.35307787
89Anhidrosis (HP:0000970)2.34304221
90Ventricular tachycardia (HP:0004756)2.33938295
91Recurrent bronchitis (HP:0002837)2.32912815
92Gingival bleeding (HP:0000225)2.32181978
93Difficulty running (HP:0009046)2.30687945
94Spontaneous hematomas (HP:0007420)2.30170286
95Verrucae (HP:0200043)2.28825571
96Papilloma (HP:0012740)2.28825571
97Exercise-induced myalgia (HP:0003738)2.25734431
98Abnormality of proline metabolism (HP:0010907)2.25274296
99Hydroxyprolinuria (HP:0003080)2.25274296
100Visceral angiomatosis (HP:0100761)2.23249817
101Acute hepatic failure (HP:0006554)2.22463830
102Abnormality of T cell number (HP:0011839)2.22251342
103Gingivitis (HP:0000230)2.21282791
104Vertigo (HP:0002321)2.21144323
105Chronic diarrhea (HP:0002028)2.19577667
106Interstitial pulmonary disease (HP:0006530)2.18985031
107Porencephaly (HP:0002132)2.18541462
108Hemangiomatosis (HP:0007461)2.18008448
109Abnormality of the hepatic vasculature (HP:0006707)2.17422330
110Atrioventricular block (HP:0001678)2.17060768
111Aplasia cutis congenita (HP:0001057)2.16363451
112Lipoatrophy (HP:0100578)2.16327917
113Tetraparesis (HP:0002273)2.15199313
114Adactyly (HP:0009776)2.15193603
115Distal lower limb amyotrophy (HP:0008944)2.14823864
116Keratoconjunctivitis (HP:0001096)2.14444529
117Pancreatic islet-cell hyperplasia (HP:0004510)2.13894728
118Calf muscle hypertrophy (HP:0008981)2.13790161
119Stomach cancer (HP:0012126)2.11812632
120Increased IgM level (HP:0003496)2.10780679
121Abnormality of the gastric mucosa (HP:0004295)2.10717726
122Abnormality of the peritoneum (HP:0002585)2.10643746
123Abnormal finger flexion creases (HP:0006143)2.09695581
124Heart block (HP:0012722)2.07723467
125Ventricular arrhythmia (HP:0004308)2.05992395
126Calcaneovalgus deformity (HP:0001848)2.05841088
127Keratoconjunctivitis sicca (HP:0001097)2.02380010
128Abnormality of macrophages (HP:0004311)2.00612782
129Amaurosis fugax (HP:0100576)2.00476421
130Abnormal atrioventricular conduction (HP:0005150)1.99404984
131Hyperkalemia (HP:0002153)1.98751707
132Deep venous thrombosis (HP:0002625)1.97533865
133Abnormality of T cells (HP:0002843)1.94993031
134Myoglobinuria (HP:0002913)1.94542283
135Abnormality of the foot musculature (HP:0001436)1.94267387
136Hemoptysis (HP:0002105)1.94175071
137Emphysema (HP:0002097)1.93845415
138Abnormality of T cell physiology (HP:0011840)1.93077113
139Muscle hypertrophy of the lower extremities (HP:0008968)1.93063484
140Exertional dyspnea (HP:0002875)1.92797350
141Viral hepatitis (HP:0006562)1.92284894
142Autoimmune hemolytic anemia (HP:0001890)1.92057481
143Exercise-induced muscle cramps (HP:0003710)1.90938627
144Progressive external ophthalmoplegia (HP:0000590)1.90674070
145Absent phalangeal crease (HP:0006109)1.89724060
146T lymphocytopenia (HP:0005403)1.87991280
147Ventricular fibrillation (HP:0001663)1.87979445
148Abnormality of the calcaneus (HP:0008364)1.87448018
149Foot dorsiflexor weakness (HP:0009027)1.84697448
150Mildly elevated creatine phosphokinase (HP:0008180)1.83553086
151Atrial fibrillation (HP:0005110)1.80252354
152Ragged-red muscle fibers (HP:0003200)1.74649699
153Abnormality of endocrine pancreas physiology (HP:0012093)1.73647852
154Abnormality of the pancreatic islet cells (HP:0006476)1.73647852
155Cerebral aneurysm (HP:0004944)1.70834518
156Hypoglycemic coma (HP:0001325)1.69442063
157Bulbar palsy (HP:0001283)1.67418321
158Scapular winging (HP:0003691)1.66968995
159Hypoglycemic seizures (HP:0002173)1.66872947
160Dislocated radial head (HP:0003083)1.65251227
161Deformed tarsal bones (HP:0008119)1.63082090
162Proximal amyotrophy (HP:0007126)1.61594138
163Myotonia (HP:0002486)1.60805059
164Hyperinsulinemic hypoglycemia (HP:0000825)1.60063109
165Abnormal foot bone ossification (HP:0010675)1.56466152
166Complement deficiency (HP:0004431)1.55239594
167Aneurysm (HP:0002617)1.53011174
168Skull defect (HP:0001362)1.52185864
169Bilateral sensorineural hearing impairment (HP:0008619)1.51525238
170Primary atrial arrhythmia (HP:0001692)1.50396324
171Muscular dystrophy (HP:0003560)1.48555513
172Spinal rigidity (HP:0003306)1.47865823
173Joint hemorrhage (HP:0005261)1.47495528
174Abnormality of the radial head (HP:0003995)1.47070915
175Lower limb amyotrophy (HP:0007210)1.45932545
176Abnormality of the common coagulation pathway (HP:0010990)1.45660198
177Abnormality of potassium homeostasis (HP:0011042)1.45376220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.91705165
2MAP3K135.03680069
3TYK24.02821932
4IKBKB3.70542783
5JAK33.47455742
6EEF2K3.16480819
7CHUK3.15289698
8FLT33.09016229
9JAK12.90422972
10TBK12.63985958
11EPHB12.44945865
12IKBKE2.31472838
13FGFR42.17566623
14PKN12.12031086
15PRPF4B2.11551474
16TTN2.09876323
17AKT32.09217033
18KSR22.01162700
19KIT1.97959479
20EPHA31.96235477
21PASK1.74355467
22CSF1R1.69442902
23FGFR31.67515287
24TIE11.65693790
25IRAK41.64080992
26TXK1.63272930
27BRD41.60128406
28MAPK121.43802993
29PTK61.40317929
30RIPK11.38869061
31NEK91.37906636
32* PRKAA21.36996750
33EIF2AK31.29638238
34MAP4K11.26229204
35RET1.24242875
36JAK21.22904338
37IRAK11.22736517
38SGK21.21581075
39TRIB31.19945781
40NLK1.18392187
41MAPK111.14991777
42SMG11.11021819
43RIPK41.03478242
44PDGFRA1.03220543
45PIK3CG0.97272962
46RAF10.97217427
47CDK40.97128192
48TSSK60.96488411
49MAP2K30.89361022
50MAP3K70.88516978
51ZAP700.87549936
52CDK60.86721032
53STK240.86049023
54MAP3K100.85846786
55LATS10.84073234
56LCK0.82764013
57LMTK20.78213311
58MTOR0.77629647
59CDC42BPA0.76529946
60PIK3CA0.76215250
61FGFR20.75681924
62WNK10.75373333
63PRKCQ0.74327712
64CSK0.74089087
65SYK0.73574627
66MAPKAPK20.72549623
67DMPK0.72400111
68OBSCN0.72178736
69SGK2230.71779530
70SGK4940.71779530
71PKN20.70781558
72LRRK20.68896958
73MAPK70.67910440
74MAPKAPK30.66856762
75GRK60.65967593
76ITK0.65510185
77STK40.64164943
78INSRR0.63854104
79RPS6KB10.63668784
80TGFBR10.62734304
81PDK10.62662469
82RPS6KB20.62051795
83RPS6KA40.61517068
84PRKAA10.61502617
85PAK30.61318920
86KDR0.60755670
87MAP3K90.58809063
88CAMK40.58552914
89TYRO30.56690403
90STK110.53768601
91FGR0.53658875
92RPS6KA10.53417094
93YES10.53250999
94PDPK10.53173130
95PHKG20.52759290
96PHKG10.52759290
97PIM10.52454019
98MAP3K10.52372047
99NEK60.51963872
100RPS6KA50.50070563
101BTK0.49080160
102FGFR10.48269103
103IRAK20.47689087
104HIPK20.47374965
105BMX0.46258994
106MAP2K20.46164708
107TRPM70.45599195
108MAP2K60.45450619
109NEK10.45315632
110ERN10.45234670
111BMPR20.44891870
112SIK10.44806126
113KSR10.44001124
114CAMKK20.43635022
115MELK0.43105366
116MAPK100.43026313
117DYRK1B0.42450248
118CAMK1D0.42071809
119GSK3A0.41824492
120MAP3K30.40268860
121SGK30.39817142
122TEC0.39126958
123MARK20.38652078
124MYLK0.38620459
125PDGFRB0.37543198
126EIF2AK20.36261595
127HCK0.36126557
128PRKCD0.34795833
129MAP3K20.34221833
130CAMK1G0.32955508
131* AKT10.32622693
132* SGK10.32491096
133MARK30.31766415
134CDK90.31583211
135STK100.31352145
136FES0.31199429
137CLK10.30954885
138CDK120.30743444
139IRAK30.29220634
140PTK2B0.28914630
141EGFR0.27191375
142SCYL20.27064086
143PRKACG0.26680089
144ABL10.25854561
145NUAK10.25132639
146TAOK30.25119265
147TGFBR20.24200800
148PRKD10.23552015
149STK30.21948792
150ICK0.21721937

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040643.81855015
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.62092050
3Leishmaniasis_Homo sapiens_hsa051402.61117144
4Toxoplasmosis_Homo sapiens_hsa051452.48547877
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.44122833
6Osteoclast differentiation_Homo sapiens_hsa043802.39381829
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.38832577
8TNF signaling pathway_Homo sapiens_hsa046682.36509252
9Apoptosis_Homo sapiens_hsa042102.17691275
10Measles_Homo sapiens_hsa051622.09509225
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.03263100
12Antigen processing and presentation_Homo sapiens_hsa046122.02993183
13Small cell lung cancer_Homo sapiens_hsa052221.98548886
14Allograft rejection_Homo sapiens_hsa053301.87185276
15B cell receptor signaling pathway_Homo sapiens_hsa046621.84143556
16Circadian rhythm_Homo sapiens_hsa047101.83740365
17Viral myocarditis_Homo sapiens_hsa054161.79565472
18Primary immunodeficiency_Homo sapiens_hsa053401.74150967
19T cell receptor signaling pathway_Homo sapiens_hsa046601.73631613
20Chemokine signaling pathway_Homo sapiens_hsa040621.71770510
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71292167
22Graft-versus-host disease_Homo sapiens_hsa053321.64493340
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63165918
24Adipocytokine signaling pathway_Homo sapiens_hsa049201.56886389
25Acute myeloid leukemia_Homo sapiens_hsa052211.56226632
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.56032380
27Glucagon signaling pathway_Homo sapiens_hsa049221.55959537
28Dilated cardiomyopathy_Homo sapiens_hsa054141.50636707
29Thyroid cancer_Homo sapiens_hsa052161.42586966
30Fatty acid biosynthesis_Homo sapiens_hsa000611.34486505
31Lysine degradation_Homo sapiens_hsa003101.34027563
32Autoimmune thyroid disease_Homo sapiens_hsa053201.32585502
33Endometrial cancer_Homo sapiens_hsa052131.31126578
34Chronic myeloid leukemia_Homo sapiens_hsa052201.29453588
35Herpes simplex infection_Homo sapiens_hsa051681.28074814
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28015424
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25091784
38Prolactin signaling pathway_Homo sapiens_hsa049171.24958515
39Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22253717
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21592455
41* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20974800
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20498810
43Influenza A_Homo sapiens_hsa051641.17523494
44Adherens junction_Homo sapiens_hsa045201.15648611
45Shigellosis_Homo sapiens_hsa051311.12783198
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10835153
47Tuberculosis_Homo sapiens_hsa051521.10353192
48Legionellosis_Homo sapiens_hsa051341.08377265
49Epstein-Barr virus infection_Homo sapiens_hsa051691.07286733
50Carbon metabolism_Homo sapiens_hsa012001.06542845
51Colorectal cancer_Homo sapiens_hsa052101.06524425
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05837895
53Inositol phosphate metabolism_Homo sapiens_hsa005621.04641861
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03118191
55Transcriptional misregulation in cancer_Homo sapiens_hsa052021.01735078
56Complement and coagulation cascades_Homo sapiens_hsa046101.01428691
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.00026489
58Long-term potentiation_Homo sapiens_hsa047200.99601666
59Pancreatic cancer_Homo sapiens_hsa052120.98569889
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98466919
61Type II diabetes mellitus_Homo sapiens_hsa049300.98456742
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97196901
63MAPK signaling pathway_Homo sapiens_hsa040100.96478703
64Pentose phosphate pathway_Homo sapiens_hsa000300.95768462
65* Insulin resistance_Homo sapiens_hsa049310.94280221
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.93922855
67Hepatitis C_Homo sapiens_hsa051600.93009153
68Glioma_Homo sapiens_hsa052140.92356590
69Arginine biosynthesis_Homo sapiens_hsa002200.92087767
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.89996494
71Vitamin B6 metabolism_Homo sapiens_hsa007500.88439914
72Viral carcinogenesis_Homo sapiens_hsa052030.88312458
73Hepatitis B_Homo sapiens_hsa051610.85789658
74HTLV-I infection_Homo sapiens_hsa051660.82018837
75Fatty acid degradation_Homo sapiens_hsa000710.82010180
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80023435
77Fatty acid metabolism_Homo sapiens_hsa012120.79059117
78p53 signaling pathway_Homo sapiens_hsa041150.78576099
79Renin secretion_Homo sapiens_hsa049240.78531398
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77947678
81PPAR signaling pathway_Homo sapiens_hsa033200.77807492
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77257356
83VEGF signaling pathway_Homo sapiens_hsa043700.76955652
84Pertussis_Homo sapiens_hsa051330.76389010
85HIF-1 signaling pathway_Homo sapiens_hsa040660.76250783
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74961336
87Platelet activation_Homo sapiens_hsa046110.74645488
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74259599
89Hematopoietic cell lineage_Homo sapiens_hsa046400.74237596
90Propanoate metabolism_Homo sapiens_hsa006400.71120989
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71120469
92MicroRNAs in cancer_Homo sapiens_hsa052060.69769391
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69560664
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67431811
95Type I diabetes mellitus_Homo sapiens_hsa049400.67037213
96mRNA surveillance pathway_Homo sapiens_hsa030150.66244263
97FoxO signaling pathway_Homo sapiens_hsa040680.65614207
98Dorso-ventral axis formation_Homo sapiens_hsa043200.64835703
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.64433917
100ErbB signaling pathway_Homo sapiens_hsa040120.64079183
101Pathways in cancer_Homo sapiens_hsa052000.63663239
102Pyruvate metabolism_Homo sapiens_hsa006200.63263807
103Salmonella infection_Homo sapiens_hsa051320.62302569
104Prion diseases_Homo sapiens_hsa050200.61165818
105Biosynthesis of amino acids_Homo sapiens_hsa012300.60894461
106Focal adhesion_Homo sapiens_hsa045100.58952233
107Oxytocin signaling pathway_Homo sapiens_hsa049210.57779089
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57490691
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56764681
110Estrogen signaling pathway_Homo sapiens_hsa049150.55332564
111Arginine and proline metabolism_Homo sapiens_hsa003300.54659030
112Ovarian steroidogenesis_Homo sapiens_hsa049130.54429555
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52652842
114Non-small cell lung cancer_Homo sapiens_hsa052230.52452801
115Insulin signaling pathway_Homo sapiens_hsa049100.52186290
116AMPK signaling pathway_Homo sapiens_hsa041520.50227959
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48341336
118African trypanosomiasis_Homo sapiens_hsa051430.48162939
119Cardiac muscle contraction_Homo sapiens_hsa042600.47919060
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.47758421
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47323879
122Proteoglycans in cancer_Homo sapiens_hsa052050.46949576
123Malaria_Homo sapiens_hsa051440.46827839
124mTOR signaling pathway_Homo sapiens_hsa041500.46520876
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42868461
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40409904
127GnRH signaling pathway_Homo sapiens_hsa049120.39312613
128Amoebiasis_Homo sapiens_hsa051460.38257067
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37730229
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36883906
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35885278
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.35708169
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35216324
134Renal cell carcinoma_Homo sapiens_hsa052110.34499384
135cAMP signaling pathway_Homo sapiens_hsa040240.33522981
136Prostate cancer_Homo sapiens_hsa052150.31638803
137Fructose and mannose metabolism_Homo sapiens_hsa000510.30638701
138Choline metabolism in cancer_Homo sapiens_hsa052310.29608119

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