Rank | Gene Set | Z-score |
---|---|---|
1 | growth hormone receptor signaling pathway (GO:0060396) | 6.57846916 |
2 | antigen processing and presentation of endogenous antigen (GO:0019883) | 6.39903796 |
3 | muscle filament sliding (GO:0030049) | 5.90414851 |
4 | actin-myosin filament sliding (GO:0033275) | 5.90414851 |
5 | positive regulation of cell size (GO:0045793) | 5.77287834 |
6 | myeloid dendritic cell differentiation (GO:0043011) | 5.69878651 |
7 | cellular response to growth hormone stimulus (GO:0071378) | 5.69407695 |
8 | regulation of interleukin-12 biosynthetic process (GO:0045075) | 5.60722400 |
9 | regulation of RIG-I signaling pathway (GO:0039535) | 5.55389054 |
10 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.46594800 |
11 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 5.46594800 |
12 | regulation of dendritic cell antigen processing and presentation (GO:0002604) | 5.38215071 |
13 | necroptotic process (GO:0070266) | 5.23801587 |
14 | negative regulation of necroptotic process (GO:0060546) | 5.19750889 |
15 | regulation of necroptotic process (GO:0060544) | 5.19071878 |
16 | negative thymic T cell selection (GO:0045060) | 5.18221112 |
17 | myeloid dendritic cell activation (GO:0001773) | 5.11219005 |
18 | CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294) | 5.04938633 |
19 | T-helper cell differentiation (GO:0042093) | 5.04938633 |
20 | natural killer cell mediated immunity (GO:0002228) | 4.99677959 |
21 | natural killer cell mediated cytotoxicity (GO:0042267) | 4.99677959 |
22 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 4.99556249 |
23 | actin-mediated cell contraction (GO:0070252) | 4.86732446 |
24 | negative T cell selection (GO:0043383) | 4.81999630 |
25 | dendritic cell differentiation (GO:0097028) | 4.72023123 |
26 | myofibril assembly (GO:0030239) | 4.69094336 |
27 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531) | 4.66475581 |
28 | regulation of T cell tolerance induction (GO:0002664) | 4.61990771 |
29 | response to muramyl dipeptide (GO:0032495) | 4.60954896 |
30 | sarcomere organization (GO:0045214) | 4.54331124 |
31 | glucocorticoid biosynthetic process (GO:0006704) | 4.48357376 |
32 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 4.40975029 |
33 | positive regulation of natural killer cell differentiation (GO:0032825) | 4.40521391 |
34 | positive regulation of antigen processing and presentation (GO:0002579) | 4.38445406 |
35 | interferon-gamma secretion (GO:0072643) | 4.37715396 |
36 | nuclear pore complex assembly (GO:0051292) | 4.36475395 |
37 | T cell differentiation involved in immune response (GO:0002292) | 4.32827964 |
38 | alpha-beta T cell differentiation involved in immune response (GO:0002293) | 4.32827964 |
39 | alpha-beta T cell activation involved in immune response (GO:0002287) | 4.32827964 |
40 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 4.22949363 |
41 | positive regulation of type I interferon-mediated signaling pathway (GO:0060340) | 4.17971794 |
42 | positive regulation of gamma-delta T cell activation (GO:0046645) | 4.16778019 |
43 | skeletal muscle contraction (GO:0003009) | 4.15302545 |
44 | actin filament-based movement (GO:0030048) | 4.14611507 |
45 | cardiac myofibril assembly (GO:0055003) | 4.10324103 |
46 | negative regulation of necrotic cell death (GO:0060547) | 4.05271203 |
47 | regulation of relaxation of muscle (GO:1901077) | 3.97653759 |
48 | creatine metabolic process (GO:0006600) | 3.91045254 |
49 | programmed necrotic cell death (GO:0097300) | 3.90221516 |
50 | mature B cell differentiation (GO:0002335) | 3.89830730 |
51 | positive regulation of interleukin-2 production (GO:0032743) | 3.86888210 |
52 | striated muscle contraction (GO:0006941) | 3.78233598 |
53 | necrotic cell death (GO:0070265) | 3.77828713 |
54 | response to prostaglandin E (GO:0034695) | 3.76315097 |
55 | regulation of antigen processing and presentation (GO:0002577) | 3.75381875 |
56 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 3.75175450 |
57 | glucocorticoid metabolic process (GO:0008211) | 3.73763709 |
58 | cardiac muscle hypertrophy (GO:0003300) | 3.71156690 |
59 | cardiac muscle contraction (GO:0060048) | 3.70299947 |
60 | negative regulation of cell killing (GO:0031342) | 3.68692674 |
61 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.68692674 |
62 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.66983316 |
63 | T cell migration (GO:0072678) | 3.66816472 |
64 | positive regulation of protein oligomerization (GO:0032461) | 3.63837154 |
65 | positive regulation of T cell cytokine production (GO:0002726) | 3.63181500 |
66 | striated muscle hypertrophy (GO:0014897) | 3.63173688 |
67 | regulation of hypersensitivity (GO:0002883) | 3.62658919 |
68 | regulation of T-helper 1 cell differentiation (GO:0045625) | 3.60058338 |
69 | NADH metabolic process (GO:0006734) | 3.58396997 |
70 | neutrophil activation (GO:0042119) | 3.57705179 |
71 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 3.55095426 |
72 | nuclear pore organization (GO:0006999) | 3.54929953 |
73 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 3.54861508 |
74 | thymic T cell selection (GO:0045061) | 3.54209372 |
75 | actomyosin structure organization (GO:0031032) | 3.49403120 |
76 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 3.45157897 |
77 | lymphocyte migration (GO:0072676) | 3.44693523 |
78 | regulation of MHC class I biosynthetic process (GO:0045343) | 3.43188593 |
79 | positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511) | 3.42081927 |
80 | cellular response to epinephrine stimulus (GO:0071872) | 3.41617101 |
81 | regulation of tolerance induction (GO:0002643) | 3.41289944 |
82 | positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) | 3.41028747 |
83 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 3.40615018 |
84 | neutrophil activation involved in immune response (GO:0002283) | 3.38617328 |
85 | positive regulation of interleukin-12 production (GO:0032735) | 3.36590138 |
86 | granulocyte activation (GO:0036230) | 3.35734176 |
87 | positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517) | 3.33888484 |
88 | regulation of necrotic cell death (GO:0010939) | 3.32097850 |
89 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.26623410 |
90 | CD4-positive, alpha-beta T cell differentiation (GO:0043367) | 3.26171113 |
91 | carnitine shuttle (GO:0006853) | 3.23566656 |
92 | positive regulation of humoral immune response (GO:0002922) | 3.23222015 |
93 | regulation of integrin activation (GO:0033623) | 3.23115790 |
94 | T cell selection (GO:0045058) | 3.18923608 |
95 | T cell activation involved in immune response (GO:0002286) | 3.18602442 |
96 | positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372) | 3.17827108 |
97 | regulation of actin filament-based movement (GO:1903115) | 3.17543136 |
98 | response to mercury ion (GO:0046689) | 3.16405267 |
99 | muscle hypertrophy (GO:0014896) | 3.15741279 |
100 | regulation of skeletal muscle contraction (GO:0014819) | 3.15262196 |
101 | fatty acid homeostasis (GO:0055089) | 3.13495124 |
102 | regulation of gamma-delta T cell differentiation (GO:0045586) | 3.13024307 |
103 | glycogen catabolic process (GO:0005980) | 3.12675071 |
104 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043) | 3.12339882 |
105 | interferon-gamma-mediated signaling pathway (GO:0060333) | 3.09166514 |
106 | leukocyte mediated cytotoxicity (GO:0001909) | 3.08782602 |
107 | regulation of response to interferon-gamma (GO:0060330) | 3.07027302 |
108 | negative regulation of innate immune response (GO:0045824) | 3.06585589 |
109 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.04957899 |
110 | response to muscle activity (GO:0014850) | 3.03894993 |
111 | response to interleukin-15 (GO:0070672) | 3.03806804 |
112 | cardiac muscle tissue morphogenesis (GO:0055008) | 3.02355964 |
113 | striated muscle adaptation (GO:0014888) | 3.02243912 |
114 | regulation of interferon-gamma-mediated signaling pathway (GO:0060334) | 3.00470873 |
115 | regulation of cellular extravasation (GO:0002691) | 2.99428494 |
116 | response to epinephrine (GO:0071871) | 2.99141760 |
117 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 2.97511197 |
118 | cellular response to antibiotic (GO:0071236) | 2.97392693 |
119 | CD4-positive, alpha-beta T cell activation (GO:0035710) | 2.97221696 |
120 | positive regulation of interleukin-17 production (GO:0032740) | 2.97142431 |
121 | positive thymic T cell selection (GO:0045059) | 2.96897298 |
122 | positive regulation of p38MAPK cascade (GO:1900745) | 2.96097557 |
123 | regulation of protein polyubiquitination (GO:1902914) | 2.95882625 |
124 | regulation of protein oligomerization (GO:0032459) | 2.94097706 |
125 | pore complex assembly (GO:0046931) | 2.92370888 |
126 | regulation of gamma-delta T cell activation (GO:0046643) | 2.91719972 |
127 | glucan catabolic process (GO:0009251) | 2.91662259 |
128 | T cell mediated immunity (GO:0002456) | 2.88968401 |
129 | regulation of histone H3-K27 methylation (GO:0061085) | 2.87017015 |
130 | regulation of interleukin-12 production (GO:0032655) | 2.85558259 |
131 | regulation of natural killer cell mediated immunity (GO:0002715) | 2.84503048 |
132 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 2.84503048 |
133 | positive regulation of tolerance induction (GO:0002645) | 2.83310383 |
134 | germinal center formation (GO:0002467) | 2.83165895 |
135 | positive regulation of B cell differentiation (GO:0045579) | 2.83094787 |
136 | muscle tissue morphogenesis (GO:0060415) | 2.82122704 |
137 | negative regulation of alpha-beta T cell activation (GO:0046636) | 2.80753245 |
138 | muscle contraction (GO:0006936) | 2.79644319 |
139 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 2.79096167 |
140 | muscle hypertrophy in response to stress (GO:0003299) | 2.79096167 |
141 | cardiac muscle adaptation (GO:0014887) | 2.79096167 |
142 | embryonic process involved in female pregnancy (GO:0060136) | 2.77776259 |
143 | histone H3-K36 demethylation (GO:0070544) | 2.77206722 |
144 | regulation of natural killer cell differentiation (GO:0032823) | 2.77164204 |
145 | regulation of B cell differentiation (GO:0045577) | 2.76722758 |
146 | adult heart development (GO:0007512) | 2.76396959 |
147 | cellular polysaccharide catabolic process (GO:0044247) | 2.75823388 |
148 | cellular response to interleukin-15 (GO:0071350) | 2.75303451 |
149 | positive regulation of inflammatory response to antigenic stimulus (GO:0002863) | 2.75163427 |
150 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 2.74689066 |
151 | regulation of cholesterol homeostasis (GO:2000188) | 2.74172487 |
152 | regulation of regulatory T cell differentiation (GO:0045589) | 2.73701249 |
153 | skeletal muscle adaptation (GO:0043501) | 2.73610674 |
154 | negative regulation of erythrocyte differentiation (GO:0045647) | 2.72999150 |
155 | regulation of T cell receptor signaling pathway (GO:0050856) | 2.72584168 |
156 | T cell homeostasis (GO:0043029) | 2.72065533 |
157 | antigen processing and presentation via MHC class Ib (GO:0002475) | 2.70637712 |
158 | positive T cell selection (GO:0043368) | 2.70488626 |
159 | striated muscle atrophy (GO:0014891) | 2.70457313 |
160 | regulation of interleukin-2 production (GO:0032663) | 2.69932431 |
161 | cytokine secretion (GO:0050663) | 2.69070232 |
162 | low-density lipoprotein particle clearance (GO:0034383) | 2.64403104 |
163 | fatty acid transmembrane transport (GO:1902001) | 2.64071542 |
164 | negative regulation of T cell mediated immunity (GO:0002710) | 2.62992439 |
165 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 2.60460124 |
166 | cellular hyperosmotic response (GO:0071474) | 2.60263601 |
167 | regulation of interleukin-2 biosynthetic process (GO:0045076) | 2.59592372 |
168 | tricarboxylic acid metabolic process (GO:0072350) | 2.58034930 |
169 | C21-steroid hormone metabolic process (GO:0008207) | 2.57696178 |
170 | response to inactivity (GO:0014854) | 2.54785931 |
171 | succinate metabolic process (GO:0006105) | 2.53038754 |
172 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369) | 2.53017931 |
173 | C21-steroid hormone biosynthetic process (GO:0006700) | 2.52608033 |
174 | oxaloacetate metabolic process (GO:0006107) | 2.51223544 |
175 | regulation of NFAT protein import into nucleus (GO:0051532) | 2.50031371 |
176 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 2.49461172 |
177 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 2.49226535 |
178 | muscle system process (GO:0003012) | 2.48677202 |
179 | 2-oxoglutarate metabolic process (GO:0006103) | 2.48569722 |
180 | NIK/NF-kappaB signaling (GO:0038061) | 11.8405582 |
Rank | Gene Set | Z-score |
---|---|---|
1 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 5.87297750 |
2 | * IRF8_22096565_ChIP-ChIP_GC-B_Human | 4.16005563 |
3 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 4.01182450 |
4 | * STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 3.67679148 |
5 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.62731897 |
6 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 3.54023244 |
7 | * NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 3.46272980 |
8 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 3.39688703 |
9 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.25768779 |
10 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 3.25273229 |
11 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 3.19396847 |
12 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.17489916 |
13 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 3.15547837 |
14 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 2.90555688 |
15 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 2.81505318 |
16 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.73437090 |
17 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.73280256 |
18 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 2.60738440 |
19 | GATA1_22025678_ChIP-Seq_K562_Human | 2.56033612 |
20 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.46647505 |
21 | * RUNX_20019798_ChIP-Seq_JUKART_Human | 2.40052455 |
22 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 2.25130644 |
23 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.19684540 |
24 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 2.18437888 |
25 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 2.17547483 |
26 | MAF_26560356_Chip-Seq_TH1_Human | 2.17436546 |
27 | VDR_24787735_ChIP-Seq_THP-1_Human | 2.14833884 |
28 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 2.12956731 |
29 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.09390317 |
30 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.05298191 |
31 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.03890762 |
32 | MYB_26560356_Chip-Seq_TH2_Human | 1.99823136 |
33 | TCF7_22412390_ChIP-Seq_EML_Mouse | 1.98746210 |
34 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.95401603 |
35 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.94322800 |
36 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.91935359 |
37 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.81945055 |
38 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.79945050 |
39 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.75899208 |
40 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.75702535 |
41 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.73541942 |
42 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.70466742 |
43 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.68106648 |
44 | GATA3_27048872_Chip-Seq_THYMUS_Human | 1.65069521 |
45 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.64513697 |
46 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.62029601 |
47 | MYB_26560356_Chip-Seq_TH1_Human | 1.61273392 |
48 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.59867617 |
49 | KDM2B_26808549_Chip-Seq_HPB-ALL_Human | 1.59793280 |
50 | * FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.59750363 |
51 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.58427517 |
52 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.57657186 |
53 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.56160672 |
54 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.51776263 |
55 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.49684747 |
56 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.49684747 |
57 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.48371027 |
58 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.44296687 |
59 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 1.43470953 |
60 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 1.39891045 |
61 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 1.38524551 |
62 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.37902655 |
63 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.37007306 |
64 | MYC_22102868_ChIP-Seq_BL_Human | 1.35853886 |
65 | SPI1_23127762_ChIP-Seq_K562_Human | 1.35513636 |
66 | NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human | 1.33302872 |
67 | * PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.28531708 |
68 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.28374005 |
69 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.27119227 |
70 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.26903999 |
71 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.25991314 |
72 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.24372132 |
73 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.24343166 |
74 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.24040939 |
75 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.20707329 |
76 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.19149794 |
77 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.15600852 |
78 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.15326073 |
79 | MAF_26560356_Chip-Seq_TH2_Human | 1.15134736 |
80 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.15094575 |
81 | UTX_26944678_Chip-Seq_JUKART_Human | 1.15042624 |
82 | SMRT_27268052_Chip-Seq_Bcells_Human | 1.14823710 |
83 | PU_27001747_Chip-Seq_BMDM_Mouse | 1.14778198 |
84 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.14703500 |
85 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.14647968 |
86 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.14632133 |
87 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.13686088 |
88 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.13095113 |
89 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.12076848 |
90 | * ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.09666974 |
91 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.09521851 |
92 | GATA3_26560356_Chip-Seq_TH2_Human | 1.09262431 |
93 | GATA1_19941826_ChIP-Seq_K562_Human | 1.07815794 |
94 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.07315600 |
95 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.07180786 |
96 | * SPI1_23547873_ChIP-Seq_NB4_Human | 1.06794029 |
97 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.04454335 |
98 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.03970718 |
99 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.03626198 |
100 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.02720074 |
101 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.01940946 |
102 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.01102292 |
103 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.01069103 |
104 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.00809287 |
105 | KDM2B_26808549_Chip-Seq_K562_Human | 0.99542981 |
106 | * STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.98755160 |
107 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.98194913 |
108 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.98194913 |
109 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 0.97013361 |
110 | * CHD1_26751641_Chip-Seq_LNCaP_Human | 0.95947920 |
111 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.95907249 |
112 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 0.95335566 |
113 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94386979 |
114 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.93886519 |
115 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.93370085 |
116 | EGR1_19032775_ChIP-ChIP_M12_Human | 0.93289078 |
117 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.92538579 |
118 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.91305130 |
119 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.90219981 |
120 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.89175680 |
121 | * GATA6_25053715_ChIP-Seq_YYC3_Human | 0.89012785 |
122 | * RACK7_27058665_Chip-Seq_MCF-7_Human | 0.88812074 |
123 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.88626265 |
124 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.87805562 |
125 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 0.87667874 |
126 | AR_21572438_ChIP-Seq_LNCaP_Human | 0.86160528 |
127 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.85717272 |
128 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.85627435 |
129 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.85501881 |
130 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.85393260 |
131 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.82107337 |
132 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.81824812 |
133 | RXR_22108803_ChIP-Seq_LS180_Human | 0.81442943 |
134 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.81282570 |
135 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.79880471 |
136 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.79880471 |
137 | GATA2_19941826_ChIP-Seq_K562_Human | 0.79836812 |
138 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.79068856 |
139 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.78446684 |
140 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.76973524 |
141 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.75186860 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002138_abnormal_hepatobiliary_system | 6.24256292 |
2 | MP0002254_reproductive_system_inflammat | 5.98153734 |
3 | MP0004510_myositis | 5.05279816 |
4 | MP0002009_preneoplasia | 4.52795843 |
5 | MP0002166_altered_tumor_susceptibility | 3.98105077 |
6 | MP0001835_abnormal_antigen_presentation | 3.77060863 |
7 | MP0000751_myopathy | 3.56612753 |
8 | MP0004145_abnormal_muscle_electrophysio | 3.33157280 |
9 | MP0005451_abnormal_body_composition | 3.27084559 |
10 | MP0000685_abnormal_immune_system | 3.16623818 |
11 | MP0001348_abnormal_lacrimal_gland | 3.13326567 |
12 | MP0002877_abnormal_melanocyte_morpholog | 3.05394480 |
13 | MP0002006_tumorigenesis | 3.01872998 |
14 | MP0000749_muscle_degeneration | 2.91569120 |
15 | MP0000569_abnormal_digit_pigmentation | 2.80338963 |
16 | MP0001873_stomach_inflammation | 2.49241662 |
17 | MP0005387_immune_system_phenotype | 2.35711941 |
18 | MP0001790_abnormal_immune_system | 2.35711941 |
19 | MP0002269_muscular_atrophy | 2.28212673 |
20 | MP0001661_extended_life_span | 2.26320940 |
21 | MP0005310_abnormal_salivary_gland | 2.26157236 |
22 | MP0002148_abnormal_hypersensitivity_rea | 2.22079835 |
23 | MP0001800_abnormal_humoral_immune | 2.21553797 |
24 | MP0000759_abnormal_skeletal_muscle | 2.07270927 |
25 | MP0003436_decreased_susceptibility_to | 2.05635999 |
26 | MP0002163_abnormal_gland_morphology | 2.04708975 |
27 | MP0002452_abnormal_antigen_presenting | 1.99621977 |
28 | MP0005000_abnormal_immune_tolerance | 1.99528763 |
29 | MP0000747_muscle_weakness | 1.97608843 |
30 | MP0004233_abnormal_muscle_weight | 1.96876276 |
31 | MP0005671_abnormal_response_to | 1.95426254 |
32 | MP0001853_heart_inflammation | 1.93260424 |
33 | MP0010368_abnormal_lymphatic_system | 1.93199847 |
34 | MP0002723_abnormal_immune_serum | 1.87725894 |
35 | MP0005369_muscle_phenotype | 1.86828234 |
36 | MP0001819_abnormal_immune_cell | 1.82908759 |
37 | MP0002420_abnormal_adaptive_immunity | 1.80805650 |
38 | MP0010352_gastrointestinal_tract_polyps | 1.68877650 |
39 | MP0002277_abnormal_respiratory_mucosa | 1.68451969 |
40 | MP0005620_abnormal_muscle_contractility | 1.64988134 |
41 | MP0003221_abnormal_cardiomyocyte_apopto | 1.64386912 |
42 | MP0002419_abnormal_innate_immunity | 1.63746668 |
43 | MP0000013_abnormal_adipose_tissue | 1.57026215 |
44 | MP0002332_abnormal_exercise_endurance | 1.54555120 |
45 | MP0001346_abnormal_lacrimal_gland | 1.51789738 |
46 | MP0009785_altered_susceptibility_to | 1.48615808 |
47 | MP0004484_altered_response_of | 1.46500095 |
48 | MP0000716_abnormal_immune_system | 1.45384327 |
49 | MP0005025_abnormal_response_to | 1.45108730 |
50 | MP0003763_abnormal_thymus_physiology | 1.44812666 |
51 | MP0005375_adipose_tissue_phenotype | 1.43158293 |
52 | MP0004947_skin_inflammation | 1.42723048 |
53 | MP0002398_abnormal_bone_marrow | 1.42006067 |
54 | MP0003300_gastrointestinal_ulcer | 1.41629628 |
55 | MP0000003_abnormal_adipose_tissue | 1.40709021 |
56 | MP0002396_abnormal_hematopoietic_system | 1.40436619 |
57 | MP0001879_abnormal_lymphatic_vessel | 1.37692361 |
58 | MP0004381_abnormal_hair_follicle | 1.33227433 |
59 | MP0003091_abnormal_cell_migration | 1.32536486 |
60 | MP0003303_peritoneal_inflammation | 1.29798121 |
61 | MP0002837_dystrophic_cardiac_calcinosis | 1.27819052 |
62 | MP0008004_abnormal_stomach_pH | 1.27183871 |
63 | MP0004084_abnormal_cardiac_muscle | 1.24238979 |
64 | MP0002127_abnormal_cardiovascular_syste | 1.21736257 |
65 | MP0002405_respiratory_system_inflammati | 1.20304935 |
66 | MP0003828_pulmonary_edema | 1.16782719 |
67 | MP0010155_abnormal_intestine_physiology | 1.13700723 |
68 | MP0002429_abnormal_blood_cell | 1.12363150 |
69 | MP0009333_abnormal_splenocyte_physiolog | 1.12308429 |
70 | MP0003705_abnormal_hypodermis_morpholog | 1.11283569 |
71 | MP0008775_abnormal_heart_ventricle | 1.09510350 |
72 | MP0003453_abnormal_keratinocyte_physiol | 1.07894281 |
73 | MP0003868_abnormal_feces_composition | 1.05409083 |
74 | MP0002933_joint_inflammation | 1.03652158 |
75 | MP0002108_abnormal_muscle_morphology | 0.99741258 |
76 | MP0002722_abnormal_immune_system | 0.99580282 |
77 | MP0005076_abnormal_cell_differentiation | 0.99334029 |
78 | MP0000703_abnormal_thymus_morphology | 0.98009605 |
79 | MP0000750_abnormal_muscle_regeneration | 0.96307020 |
80 | MP0000689_abnormal_spleen_morphology | 0.95136472 |
81 | MP0006138_congestive_heart_failure | 0.93973543 |
82 | MP0003448_altered_tumor_morphology | 0.92987546 |
83 | MP0003984_embryonic_growth_retardation | 0.91772034 |
84 | MP0001845_abnormal_inflammatory_respons | 0.91696868 |
85 | MP0010630_abnormal_cardiac_muscle | 0.91506264 |
86 | MP0002088_abnormal_embryonic_growth/wei | 0.91160943 |
87 | MP0001915_intracranial_hemorrhage | 0.90967041 |
88 | MP0000604_amyloidosis | 0.90954327 |
89 | MP0006036_abnormal_mitochondrial_physio | 0.88836932 |
90 | MP0004130_abnormal_muscle_cell | 0.88792860 |
91 | MP0005379_endocrine/exocrine_gland_phen | 0.88596059 |
92 | MP0005670_abnormal_white_adipose | 0.88181546 |
93 | MP0003950_abnormal_plasma_membrane | 0.88149130 |
94 | MP0003866_abnormal_defecation | 0.84848152 |
95 | MP0005666_abnormal_adipose_tissue | 0.82696711 |
96 | MP0004087_abnormal_muscle_fiber | 0.81736803 |
97 | MP0003045_fibrosis | 0.81193793 |
98 | MP0003567_abnormal_fetal_cardiomyocyte | 0.80707301 |
99 | MP0000767_abnormal_smooth_muscle | 0.80318707 |
100 | MP0002998_abnormal_bone_remodeling | 0.80001656 |
101 | MP0005266_abnormal_metabolism | 0.79733397 |
102 | MP0001881_abnormal_mammary_gland | 0.79732866 |
103 | MP0005174_abnormal_tail_pigmentation | 0.79567025 |
104 | MP0001730_embryonic_growth_arrest | 0.78361432 |
105 | MP0008469_abnormal_protein_level | 0.77984850 |
106 | MP0000371_diluted_coat_color | 0.77845949 |
107 | MP0001533_abnormal_skeleton_physiology | 0.77666689 |
108 | MP0004185_abnormal_adipocyte_glucose | 0.77426819 |
109 | MP0000266_abnormal_heart_morphology | 0.77130293 |
110 | MP0009764_decreased_sensitivity_to | 0.76840181 |
111 | MP0004808_abnormal_hematopoietic_stem | 0.76493024 |
112 | MP0008872_abnormal_physiological_respon | 0.75282306 |
113 | MP0002128_abnormal_blood_circulation | 0.73643945 |
114 | MP0004036_abnormal_muscle_relaxation | 0.70452110 |
115 | MP0000733_abnormal_muscle_development | 0.70310350 |
116 | MP0009840_abnormal_foam_cell | 0.69954672 |
117 | MP0008057_abnormal_DNA_replication | 0.69912591 |
118 | MP0005058_abnormal_lysosome_morphology | 0.68752214 |
119 | MP0000249_abnormal_blood_vessel | 0.68462452 |
120 | MP0005409_darkened_coat_color | 0.68431417 |
121 | MP0004272_abnormal_basement_membrane | 0.68135960 |
122 | MP0001851_eye_inflammation | 0.67785801 |
123 | MP0001243_abnormal_dermal_layer | 0.67674880 |
124 | MP0005385_cardiovascular_system_phenoty | 0.67503705 |
125 | MP0001544_abnormal_cardiovascular_syste | 0.67503705 |
126 | MP0001672_abnormal_embryogenesis/_devel | 0.67373127 |
127 | MP0005380_embryogenesis_phenotype | 0.67373127 |
128 | MP0001545_abnormal_hematopoietic_system | 0.67057925 |
129 | MP0005397_hematopoietic_system_phenotyp | 0.67057925 |
130 | MP0002972_abnormal_cardiac_muscle | 0.66067081 |
131 | MP0009115_abnormal_fat_cell | 0.65972709 |
132 | MP0005623_abnormal_meninges_morphology | 0.65630893 |
133 | MP0003646_muscle_fatigue | 0.65242424 |
134 | MP0001765_abnormal_ion_homeostasis | 0.64040013 |
135 | MP0002971_abnormal_brown_adipose | 0.63763171 |
136 | MP0002078_abnormal_glucose_homeostasis | 0.63373134 |
137 | MP0005464_abnormal_platelet_physiology | 0.61800911 |
138 | MP0002693_abnormal_pancreas_physiology | 0.61058040 |
139 | MP0003943_abnormal_hepatobiliary_system | 0.60846996 |
140 | MP0003566_abnormal_cell_adhesion | 0.60018605 |
141 | MP0002106_abnormal_muscle_physiology | 0.58551052 |
142 | MP0004215_abnormal_myocardial_fiber | 0.58047093 |
143 | MP0002295_abnormal_pulmonary_circulatio | 0.56078561 |
144 | MP0010234_abnormal_vibrissa_follicle | 0.53917343 |
145 | MP0002136_abnormal_kidney_physiology | 0.52092093 |
146 | MP0005330_cardiomyopathy | 0.50115348 |
147 | MP0003183_abnormal_peptide_metabolism | 0.49322491 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Muscle fiber inclusion bodies (HP:0100299) | 6.93128348 |
2 | Nemaline bodies (HP:0003798) | 6.91732055 |
3 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 6.68153450 |
4 | Fatigue (HP:0012378) | 5.72001122 |
5 | Type 1 muscle fiber predominance (HP:0003803) | 5.06151232 |
6 | Recurrent viral infections (HP:0004429) | 5.05263767 |
7 | Recurrent fungal infections (HP:0002841) | 5.02919711 |
8 | Abnormality of the left ventricular outflow tract (HP:0011103) | 4.75671835 |
9 | Subaortic stenosis (HP:0001682) | 4.75671835 |
10 | Polycythemia (HP:0001901) | 4.50909719 |
11 | Hematochezia (HP:0002573) | 4.28173967 |
12 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 4.26079696 |
13 | Myocardial infarction (HP:0001658) | 4.21934207 |
14 | Cortical dysplasia (HP:0002539) | 4.20543912 |
15 | EMG: myopathic abnormalities (HP:0003458) | 4.12549053 |
16 | Colitis (HP:0002583) | 4.08269290 |
17 | Increased IgE level (HP:0003212) | 4.04217576 |
18 | Thrombocytosis (HP:0001894) | 3.90996998 |
19 | Gastrointestinal infarctions (HP:0005244) | 3.84411300 |
20 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 3.82301698 |
21 | Eczematoid dermatitis (HP:0000976) | 3.78959171 |
22 | Recurrent bacterial skin infections (HP:0005406) | 3.77523127 |
23 | Cerebral hemorrhage (HP:0001342) | 3.76015001 |
24 | Pulmonary infiltrates (HP:0002113) | 3.71549538 |
25 | Rhabdomyolysis (HP:0003201) | 3.66688436 |
26 | Mediastinal lymphadenopathy (HP:0100721) | 3.62926966 |
27 | Chronic otitis media (HP:0000389) | 3.59862269 |
28 | Myopathic facies (HP:0002058) | 3.59836843 |
29 | Peritonitis (HP:0002586) | 3.55784279 |
30 | Recurrent abscess formation (HP:0002722) | 3.52371206 |
31 | Esophageal varix (HP:0002040) | 3.52076522 |
32 | Arterial thrombosis (HP:0004420) | 3.49650218 |
33 | Recurrent cutaneous fungal infections (HP:0011370) | 3.48846115 |
34 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.48846115 |
35 | Nasal polyposis (HP:0100582) | 3.39815017 |
36 | Eosinophilia (HP:0001880) | 3.36854795 |
37 | Abnormality of skeletal muscle fiber size (HP:0012084) | 3.34930651 |
38 | Neck muscle weakness (HP:0000467) | 3.31496267 |
39 | Agammaglobulinemia (HP:0004432) | 3.29603563 |
40 | Muscle fiber splitting (HP:0003555) | 3.27442820 |
41 | Increased connective tissue (HP:0009025) | 3.27193039 |
42 | Abnormality of the fingertips (HP:0001211) | 3.25623915 |
43 | Dysmetric saccades (HP:0000641) | 3.20874824 |
44 | Asymmetric septal hypertrophy (HP:0001670) | 3.18844656 |
45 | Inflammation of the large intestine (HP:0002037) | 3.16380084 |
46 | Abnormality of the nasal mucosa (HP:0000433) | 3.14709945 |
47 | Panhypogammaglobulinemia (HP:0003139) | 3.13881672 |
48 | Bundle branch block (HP:0011710) | 3.13843242 |
49 | Distal arthrogryposis (HP:0005684) | 3.13090426 |
50 | Optic neuritis (HP:0100653) | 3.12294867 |
51 | Retrobulbar optic neuritis (HP:0100654) | 3.12294867 |
52 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.10072529 |
53 | Myositis (HP:0100614) | 3.06485849 |
54 | Periodontitis (HP:0000704) | 3.06116486 |
55 | Round ear (HP:0100830) | 3.05584176 |
56 | Abnormality of the calf musculature (HP:0001430) | 3.03899039 |
57 | Recurrent skin infections (HP:0001581) | 3.03611319 |
58 | Leukocytosis (HP:0001974) | 2.99894759 |
59 | Tinnitus (HP:0000360) | 2.96353751 |
60 | Granulocytopenia (HP:0001913) | 2.96250359 |
61 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.94856944 |
62 | Osteolytic defects of the hand bones (HP:0009699) | 2.94856944 |
63 | Increased variability in muscle fiber diameter (HP:0003557) | 2.92765710 |
64 | Gastrointestinal inflammation (HP:0004386) | 2.92043690 |
65 | Ulnar deviation of the wrist (HP:0003049) | 2.91665898 |
66 | Orchitis (HP:0100796) | 2.90341155 |
67 | Acute myeloid leukemia (HP:0004808) | 2.85468753 |
68 | Hyporeflexia of lower limbs (HP:0002600) | 2.80306275 |
69 | Sudden death (HP:0001699) | 2.77095067 |
70 | Frequent falls (HP:0002359) | 2.72478706 |
71 | Chest pain (HP:0100749) | 2.67969402 |
72 | Abnormality of the periventricular white matter (HP:0002518) | 2.64411910 |
73 | EMG: neuropathic changes (HP:0003445) | 2.61065138 |
74 | Persistence of primary teeth (HP:0006335) | 2.60412229 |
75 | Dilated cardiomyopathy (HP:0001644) | 2.59082160 |
76 | Abnormality of eosinophils (HP:0001879) | 2.57860249 |
77 | Right ventricular cardiomyopathy (HP:0011663) | 2.57532920 |
78 | Hypergammaglobulinemia (HP:0010702) | 2.52052130 |
79 | Distal lower limb muscle weakness (HP:0009053) | 2.48974857 |
80 | Muscle stiffness (HP:0003552) | 2.48347444 |
81 | Malignant hyperthermia (HP:0002047) | 2.43482125 |
82 | Areflexia of lower limbs (HP:0002522) | 2.43336486 |
83 | Rimmed vacuoles (HP:0003805) | 2.39790262 |
84 | Portal hypertension (HP:0001409) | 2.38981341 |
85 | Progressive muscle weakness (HP:0003323) | 2.37127033 |
86 | Generalized muscle weakness (HP:0003324) | 2.36927393 |
87 | Vasculitis (HP:0002633) | 2.36648336 |
88 | Pulmonary artery stenosis (HP:0004415) | 2.35307787 |
89 | Anhidrosis (HP:0000970) | 2.34304221 |
90 | Ventricular tachycardia (HP:0004756) | 2.33938295 |
91 | Recurrent bronchitis (HP:0002837) | 2.32912815 |
92 | Gingival bleeding (HP:0000225) | 2.32181978 |
93 | Difficulty running (HP:0009046) | 2.30687945 |
94 | Spontaneous hematomas (HP:0007420) | 2.30170286 |
95 | Verrucae (HP:0200043) | 2.28825571 |
96 | Papilloma (HP:0012740) | 2.28825571 |
97 | Exercise-induced myalgia (HP:0003738) | 2.25734431 |
98 | Abnormality of proline metabolism (HP:0010907) | 2.25274296 |
99 | Hydroxyprolinuria (HP:0003080) | 2.25274296 |
100 | Visceral angiomatosis (HP:0100761) | 2.23249817 |
101 | Acute hepatic failure (HP:0006554) | 2.22463830 |
102 | Abnormality of T cell number (HP:0011839) | 2.22251342 |
103 | Gingivitis (HP:0000230) | 2.21282791 |
104 | Vertigo (HP:0002321) | 2.21144323 |
105 | Chronic diarrhea (HP:0002028) | 2.19577667 |
106 | Interstitial pulmonary disease (HP:0006530) | 2.18985031 |
107 | Porencephaly (HP:0002132) | 2.18541462 |
108 | Hemangiomatosis (HP:0007461) | 2.18008448 |
109 | Abnormality of the hepatic vasculature (HP:0006707) | 2.17422330 |
110 | Atrioventricular block (HP:0001678) | 2.17060768 |
111 | Aplasia cutis congenita (HP:0001057) | 2.16363451 |
112 | Lipoatrophy (HP:0100578) | 2.16327917 |
113 | Tetraparesis (HP:0002273) | 2.15199313 |
114 | Adactyly (HP:0009776) | 2.15193603 |
115 | Distal lower limb amyotrophy (HP:0008944) | 2.14823864 |
116 | Keratoconjunctivitis (HP:0001096) | 2.14444529 |
117 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.13894728 |
118 | Calf muscle hypertrophy (HP:0008981) | 2.13790161 |
119 | Stomach cancer (HP:0012126) | 2.11812632 |
120 | Increased IgM level (HP:0003496) | 2.10780679 |
121 | Abnormality of the gastric mucosa (HP:0004295) | 2.10717726 |
122 | Abnormality of the peritoneum (HP:0002585) | 2.10643746 |
123 | Abnormal finger flexion creases (HP:0006143) | 2.09695581 |
124 | Heart block (HP:0012722) | 2.07723467 |
125 | Ventricular arrhythmia (HP:0004308) | 2.05992395 |
126 | Calcaneovalgus deformity (HP:0001848) | 2.05841088 |
127 | Keratoconjunctivitis sicca (HP:0001097) | 2.02380010 |
128 | Abnormality of macrophages (HP:0004311) | 2.00612782 |
129 | Amaurosis fugax (HP:0100576) | 2.00476421 |
130 | Abnormal atrioventricular conduction (HP:0005150) | 1.99404984 |
131 | Hyperkalemia (HP:0002153) | 1.98751707 |
132 | Deep venous thrombosis (HP:0002625) | 1.97533865 |
133 | Abnormality of T cells (HP:0002843) | 1.94993031 |
134 | Myoglobinuria (HP:0002913) | 1.94542283 |
135 | Abnormality of the foot musculature (HP:0001436) | 1.94267387 |
136 | Hemoptysis (HP:0002105) | 1.94175071 |
137 | Emphysema (HP:0002097) | 1.93845415 |
138 | Abnormality of T cell physiology (HP:0011840) | 1.93077113 |
139 | Muscle hypertrophy of the lower extremities (HP:0008968) | 1.93063484 |
140 | Exertional dyspnea (HP:0002875) | 1.92797350 |
141 | Viral hepatitis (HP:0006562) | 1.92284894 |
142 | Autoimmune hemolytic anemia (HP:0001890) | 1.92057481 |
143 | Exercise-induced muscle cramps (HP:0003710) | 1.90938627 |
144 | Progressive external ophthalmoplegia (HP:0000590) | 1.90674070 |
145 | Absent phalangeal crease (HP:0006109) | 1.89724060 |
146 | T lymphocytopenia (HP:0005403) | 1.87991280 |
147 | Ventricular fibrillation (HP:0001663) | 1.87979445 |
148 | Abnormality of the calcaneus (HP:0008364) | 1.87448018 |
149 | Foot dorsiflexor weakness (HP:0009027) | 1.84697448 |
150 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.83553086 |
151 | Atrial fibrillation (HP:0005110) | 1.80252354 |
152 | Ragged-red muscle fibers (HP:0003200) | 1.74649699 |
153 | Abnormality of endocrine pancreas physiology (HP:0012093) | 1.73647852 |
154 | Abnormality of the pancreatic islet cells (HP:0006476) | 1.73647852 |
155 | Cerebral aneurysm (HP:0004944) | 1.70834518 |
156 | Hypoglycemic coma (HP:0001325) | 1.69442063 |
157 | Bulbar palsy (HP:0001283) | 1.67418321 |
158 | Scapular winging (HP:0003691) | 1.66968995 |
159 | Hypoglycemic seizures (HP:0002173) | 1.66872947 |
160 | Dislocated radial head (HP:0003083) | 1.65251227 |
161 | Deformed tarsal bones (HP:0008119) | 1.63082090 |
162 | Proximal amyotrophy (HP:0007126) | 1.61594138 |
163 | Myotonia (HP:0002486) | 1.60805059 |
164 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.60063109 |
165 | Abnormal foot bone ossification (HP:0010675) | 1.56466152 |
166 | Complement deficiency (HP:0004431) | 1.55239594 |
167 | Aneurysm (HP:0002617) | 1.53011174 |
168 | Skull defect (HP:0001362) | 1.52185864 |
169 | Bilateral sensorineural hearing impairment (HP:0008619) | 1.51525238 |
170 | Primary atrial arrhythmia (HP:0001692) | 1.50396324 |
171 | Muscular dystrophy (HP:0003560) | 1.48555513 |
172 | Spinal rigidity (HP:0003306) | 1.47865823 |
173 | Joint hemorrhage (HP:0005261) | 1.47495528 |
174 | Abnormality of the radial head (HP:0003995) | 1.47070915 |
175 | Lower limb amyotrophy (HP:0007210) | 1.45932545 |
176 | Abnormality of the common coagulation pathway (HP:0010990) | 1.45660198 |
177 | Abnormality of potassium homeostasis (HP:0011042) | 1.45376220 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MAP3K14 | 5.91705165 |
2 | MAP3K13 | 5.03680069 |
3 | TYK2 | 4.02821932 |
4 | IKBKB | 3.70542783 |
5 | JAK3 | 3.47455742 |
6 | EEF2K | 3.16480819 |
7 | CHUK | 3.15289698 |
8 | FLT3 | 3.09016229 |
9 | JAK1 | 2.90422972 |
10 | TBK1 | 2.63985958 |
11 | EPHB1 | 2.44945865 |
12 | IKBKE | 2.31472838 |
13 | FGFR4 | 2.17566623 |
14 | PKN1 | 2.12031086 |
15 | PRPF4B | 2.11551474 |
16 | TTN | 2.09876323 |
17 | AKT3 | 2.09217033 |
18 | KSR2 | 2.01162700 |
19 | KIT | 1.97959479 |
20 | EPHA3 | 1.96235477 |
21 | PASK | 1.74355467 |
22 | CSF1R | 1.69442902 |
23 | FGFR3 | 1.67515287 |
24 | TIE1 | 1.65693790 |
25 | IRAK4 | 1.64080992 |
26 | TXK | 1.63272930 |
27 | BRD4 | 1.60128406 |
28 | MAPK12 | 1.43802993 |
29 | PTK6 | 1.40317929 |
30 | RIPK1 | 1.38869061 |
31 | NEK9 | 1.37906636 |
32 | * PRKAA2 | 1.36996750 |
33 | EIF2AK3 | 1.29638238 |
34 | MAP4K1 | 1.26229204 |
35 | RET | 1.24242875 |
36 | JAK2 | 1.22904338 |
37 | IRAK1 | 1.22736517 |
38 | SGK2 | 1.21581075 |
39 | TRIB3 | 1.19945781 |
40 | NLK | 1.18392187 |
41 | MAPK11 | 1.14991777 |
42 | SMG1 | 1.11021819 |
43 | RIPK4 | 1.03478242 |
44 | PDGFRA | 1.03220543 |
45 | PIK3CG | 0.97272962 |
46 | RAF1 | 0.97217427 |
47 | CDK4 | 0.97128192 |
48 | TSSK6 | 0.96488411 |
49 | MAP2K3 | 0.89361022 |
50 | MAP3K7 | 0.88516978 |
51 | ZAP70 | 0.87549936 |
52 | CDK6 | 0.86721032 |
53 | STK24 | 0.86049023 |
54 | MAP3K10 | 0.85846786 |
55 | LATS1 | 0.84073234 |
56 | LCK | 0.82764013 |
57 | LMTK2 | 0.78213311 |
58 | MTOR | 0.77629647 |
59 | CDC42BPA | 0.76529946 |
60 | PIK3CA | 0.76215250 |
61 | FGFR2 | 0.75681924 |
62 | WNK1 | 0.75373333 |
63 | PRKCQ | 0.74327712 |
64 | CSK | 0.74089087 |
65 | SYK | 0.73574627 |
66 | MAPKAPK2 | 0.72549623 |
67 | DMPK | 0.72400111 |
68 | OBSCN | 0.72178736 |
69 | SGK223 | 0.71779530 |
70 | SGK494 | 0.71779530 |
71 | PKN2 | 0.70781558 |
72 | LRRK2 | 0.68896958 |
73 | MAPK7 | 0.67910440 |
74 | MAPKAPK3 | 0.66856762 |
75 | GRK6 | 0.65967593 |
76 | ITK | 0.65510185 |
77 | STK4 | 0.64164943 |
78 | INSRR | 0.63854104 |
79 | RPS6KB1 | 0.63668784 |
80 | TGFBR1 | 0.62734304 |
81 | PDK1 | 0.62662469 |
82 | RPS6KB2 | 0.62051795 |
83 | RPS6KA4 | 0.61517068 |
84 | PRKAA1 | 0.61502617 |
85 | PAK3 | 0.61318920 |
86 | KDR | 0.60755670 |
87 | MAP3K9 | 0.58809063 |
88 | CAMK4 | 0.58552914 |
89 | TYRO3 | 0.56690403 |
90 | STK11 | 0.53768601 |
91 | FGR | 0.53658875 |
92 | RPS6KA1 | 0.53417094 |
93 | YES1 | 0.53250999 |
94 | PDPK1 | 0.53173130 |
95 | PHKG2 | 0.52759290 |
96 | PHKG1 | 0.52759290 |
97 | PIM1 | 0.52454019 |
98 | MAP3K1 | 0.52372047 |
99 | NEK6 | 0.51963872 |
100 | RPS6KA5 | 0.50070563 |
101 | BTK | 0.49080160 |
102 | FGFR1 | 0.48269103 |
103 | IRAK2 | 0.47689087 |
104 | HIPK2 | 0.47374965 |
105 | BMX | 0.46258994 |
106 | MAP2K2 | 0.46164708 |
107 | TRPM7 | 0.45599195 |
108 | MAP2K6 | 0.45450619 |
109 | NEK1 | 0.45315632 |
110 | ERN1 | 0.45234670 |
111 | BMPR2 | 0.44891870 |
112 | SIK1 | 0.44806126 |
113 | KSR1 | 0.44001124 |
114 | CAMKK2 | 0.43635022 |
115 | MELK | 0.43105366 |
116 | MAPK10 | 0.43026313 |
117 | DYRK1B | 0.42450248 |
118 | CAMK1D | 0.42071809 |
119 | GSK3A | 0.41824492 |
120 | MAP3K3 | 0.40268860 |
121 | SGK3 | 0.39817142 |
122 | TEC | 0.39126958 |
123 | MARK2 | 0.38652078 |
124 | MYLK | 0.38620459 |
125 | PDGFRB | 0.37543198 |
126 | EIF2AK2 | 0.36261595 |
127 | HCK | 0.36126557 |
128 | PRKCD | 0.34795833 |
129 | MAP3K2 | 0.34221833 |
130 | CAMK1G | 0.32955508 |
131 | * AKT1 | 0.32622693 |
132 | * SGK1 | 0.32491096 |
133 | MARK3 | 0.31766415 |
134 | CDK9 | 0.31583211 |
135 | STK10 | 0.31352145 |
136 | FES | 0.31199429 |
137 | CLK1 | 0.30954885 |
138 | CDK12 | 0.30743444 |
139 | IRAK3 | 0.29220634 |
140 | PTK2B | 0.28914630 |
141 | EGFR | 0.27191375 |
142 | SCYL2 | 0.27064086 |
143 | PRKACG | 0.26680089 |
144 | ABL1 | 0.25854561 |
145 | NUAK1 | 0.25132639 |
146 | TAOK3 | 0.25119265 |
147 | TGFBR2 | 0.24200800 |
148 | PRKD1 | 0.23552015 |
149 | STK3 | 0.21948792 |
150 | ICK | 0.21721937 |
Rank | Gene Set | Z-score |
---|---|---|
1 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 3.81855015 |
2 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.62092050 |
3 | Leishmaniasis_Homo sapiens_hsa05140 | 2.61117144 |
4 | Toxoplasmosis_Homo sapiens_hsa05145 | 2.48547877 |
5 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 2.44122833 |
6 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.39381829 |
7 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.38832577 |
8 | TNF signaling pathway_Homo sapiens_hsa04668 | 2.36509252 |
9 | Apoptosis_Homo sapiens_hsa04210 | 2.17691275 |
10 | Measles_Homo sapiens_hsa05162 | 2.09509225 |
11 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.03263100 |
12 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.02993183 |
13 | Small cell lung cancer_Homo sapiens_hsa05222 | 1.98548886 |
14 | Allograft rejection_Homo sapiens_hsa05330 | 1.87185276 |
15 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.84143556 |
16 | Circadian rhythm_Homo sapiens_hsa04710 | 1.83740365 |
17 | Viral myocarditis_Homo sapiens_hsa05416 | 1.79565472 |
18 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.74150967 |
19 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.73631613 |
20 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.71770510 |
21 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.71292167 |
22 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.64493340 |
23 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.63165918 |
24 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.56886389 |
25 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.56226632 |
26 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.56032380 |
27 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.55959537 |
28 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.50636707 |
29 | Thyroid cancer_Homo sapiens_hsa05216 | 1.42586966 |
30 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.34486505 |
31 | Lysine degradation_Homo sapiens_hsa00310 | 1.34027563 |
32 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.32585502 |
33 | Endometrial cancer_Homo sapiens_hsa05213 | 1.31126578 |
34 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.29453588 |
35 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.28074814 |
36 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.28015424 |
37 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.25091784 |
38 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.24958515 |
39 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.22253717 |
40 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.21592455 |
41 | * Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.20974800 |
42 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.20498810 |
43 | Influenza A_Homo sapiens_hsa05164 | 1.17523494 |
44 | Adherens junction_Homo sapiens_hsa04520 | 1.15648611 |
45 | Shigellosis_Homo sapiens_hsa05131 | 1.12783198 |
46 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.10835153 |
47 | Tuberculosis_Homo sapiens_hsa05152 | 1.10353192 |
48 | Legionellosis_Homo sapiens_hsa05134 | 1.08377265 |
49 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.07286733 |
50 | Carbon metabolism_Homo sapiens_hsa01200 | 1.06542845 |
51 | Colorectal cancer_Homo sapiens_hsa05210 | 1.06524425 |
52 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.05837895 |
53 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.04641861 |
54 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.03118191 |
55 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.01735078 |
56 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.01428691 |
57 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.00026489 |
58 | Long-term potentiation_Homo sapiens_hsa04720 | 0.99601666 |
59 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.98569889 |
60 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.98466919 |
61 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.98456742 |
62 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.97196901 |
63 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.96478703 |
64 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.95768462 |
65 | * Insulin resistance_Homo sapiens_hsa04931 | 0.94280221 |
66 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.93922855 |
67 | Hepatitis C_Homo sapiens_hsa05160 | 0.93009153 |
68 | Glioma_Homo sapiens_hsa05214 | 0.92356590 |
69 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.92087767 |
70 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.89996494 |
71 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.88439914 |
72 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.88312458 |
73 | Hepatitis B_Homo sapiens_hsa05161 | 0.85789658 |
74 | HTLV-I infection_Homo sapiens_hsa05166 | 0.82018837 |
75 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.82010180 |
76 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.80023435 |
77 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.79059117 |
78 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.78576099 |
79 | Renin secretion_Homo sapiens_hsa04924 | 0.78531398 |
80 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.77947678 |
81 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.77807492 |
82 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.77257356 |
83 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.76955652 |
84 | Pertussis_Homo sapiens_hsa05133 | 0.76389010 |
85 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.76250783 |
86 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.74961336 |
87 | Platelet activation_Homo sapiens_hsa04611 | 0.74645488 |
88 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.74259599 |
89 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.74237596 |
90 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.71120989 |
91 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.71120469 |
92 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.69769391 |
93 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.69560664 |
94 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.67431811 |
95 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.67037213 |
96 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.66244263 |
97 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.65614207 |
98 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.64835703 |
99 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.64433917 |
100 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.64079183 |
101 | Pathways in cancer_Homo sapiens_hsa05200 | 0.63663239 |
102 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.63263807 |
103 | Salmonella infection_Homo sapiens_hsa05132 | 0.62302569 |
104 | Prion diseases_Homo sapiens_hsa05020 | 0.61165818 |
105 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.60894461 |
106 | Focal adhesion_Homo sapiens_hsa04510 | 0.58952233 |
107 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.57779089 |
108 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.57490691 |
109 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.56764681 |
110 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.55332564 |
111 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.54659030 |
112 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.54429555 |
113 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.52652842 |
114 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.52452801 |
115 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.52186290 |
116 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.50227959 |
117 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.48341336 |
118 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.48162939 |
119 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.47919060 |
120 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.47758421 |
121 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.47323879 |
122 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.46949576 |
123 | Malaria_Homo sapiens_hsa05144 | 0.46827839 |
124 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.46520876 |
125 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.42868461 |
126 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.40409904 |
127 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.39312613 |
128 | Amoebiasis_Homo sapiens_hsa05146 | 0.38257067 |
129 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.37730229 |
130 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.36883906 |
131 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.35885278 |
132 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.35708169 |
133 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.35216324 |
134 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.34499384 |
135 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.33522981 |
136 | Prostate cancer_Homo sapiens_hsa05215 | 0.31638803 |
137 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.30638701 |
138 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.29608119 |