TBC1D5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.01234189
2regulation of interferon-beta biosynthetic process (GO:0045357)5.15952204
3peptidyl-tyrosine autophosphorylation (GO:0038083)4.81689818
4positive regulation of B cell differentiation (GO:0045579)4.59731526
5regulation of B cell receptor signaling pathway (GO:0050855)4.58561390
6positive regulation of gamma-delta T cell activation (GO:0046645)4.49060239
7positive regulation by symbiont of host defense response (GO:0052509)4.30099135
8modulation by symbiont of host defense response (GO:0052031)4.30099135
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.30099135
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.30099135
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.30099135
12modulation by symbiont of host immune response (GO:0052553)4.30099135
13interkinetic nuclear migration (GO:0022027)4.26828655
14antigen processing and presentation of endogenous antigen (GO:0019883)4.25525547
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.23651446
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.23651446
17neutrophil activation involved in immune response (GO:0002283)3.99462063
18negative regulation of granulocyte differentiation (GO:0030853)3.96196622
19B cell receptor signaling pathway (GO:0050853)3.95469029
20macrophage activation involved in immune response (GO:0002281)3.87169564
21regulation of B cell differentiation (GO:0045577)3.84400832
22cellular response to ethanol (GO:0071361)3.63447558
23megakaryocyte development (GO:0035855)3.59819827
24angiogenesis involved in wound healing (GO:0060055)3.59342656
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.59228084
26cellular extravasation (GO:0045123)3.29496190
27phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.29172284
28regulation of interleukin-12 biosynthetic process (GO:0045075)3.29072037
29negative regulation of phagocytosis (GO:0050765)3.27900854
30myeloid cell activation involved in immune response (GO:0002275)3.26846437
31regulation of memory T cell differentiation (GO:0043380)3.18894353
32positive regulation of interferon-alpha production (GO:0032727)3.16009605
33actin filament polymerization (GO:0030041)3.15771391
34regulation of gamma-delta T cell differentiation (GO:0045586)3.15289930
35response to lipoprotein particle (GO:0055094)3.10847785
36mast cell activation (GO:0045576)3.10292159
37nucleus localization (GO:0051647)3.07978491
38cytoplasmic mRNA processing body assembly (GO:0033962)3.07152738
39cortical actin cytoskeleton organization (GO:0030866)3.06348195
40negative regulation of B cell proliferation (GO:0030889)3.02746713
41pinocytosis (GO:0006907)3.02567805
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.99895719
43antigen processing and presentation via MHC class Ib (GO:0002475)2.99667547
44negative regulation of neurotransmitter transport (GO:0051589)2.99325783
45regulation of interferon-alpha production (GO:0032647)2.99151747
46regulation of gamma-delta T cell activation (GO:0046643)2.97124298
47respiratory burst (GO:0045730)2.93250261
48positive regulation of Rap GTPase activity (GO:0032854)2.92788603
49import into cell (GO:0098657)2.91337414
50neutrophil activation (GO:0042119)2.91090457
51astrocyte development (GO:0014002)2.90902290
52microglial cell activation (GO:0001774)2.88642660
53phagocytosis, engulfment (GO:0006911)2.88218766
54positive regulation of histone deacetylation (GO:0031065)2.88023857
55regulation of telomere maintenance via telomerase (GO:0032210)2.85720937
56regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.84905043
57regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84832322
58myeloid dendritic cell activation (GO:0001773)2.84169810
59B cell homeostasis (GO:0001782)2.82972440
60positive regulation of antigen processing and presentation (GO:0002579)2.77766148
61regulation of ARF GTPase activity (GO:0032312)2.76715895
62regulation of ARF protein signal transduction (GO:0032012)2.76563404
63DNA damage induced protein phosphorylation (GO:0006975)2.74876737
64negative regulation of neurotransmitter secretion (GO:0046929)2.74126635
65positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.73545052
66germinal center formation (GO:0002467)2.72995028
67immunoglobulin mediated immune response (GO:0016064)2.72228703
68mature B cell differentiation (GO:0002335)2.71856579
69lipid translocation (GO:0034204)2.71282662
70phospholipid translocation (GO:0045332)2.71282662
71regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.67734401
72type B pancreatic cell development (GO:0003323)2.67106078
73response to laminar fluid shear stress (GO:0034616)2.66517575
74macrophage activation (GO:0042116)2.65483596
75regulation of granulocyte differentiation (GO:0030852)2.65435272
76positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.64841708
77negative regulation of cell killing (GO:0031342)2.64289763
78negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.64289763
79negative regulation of erythrocyte differentiation (GO:0045647)2.62260963
80granulocyte activation (GO:0036230)2.62066070
81histone H3-K36 demethylation (GO:0070544)2.61727033
82positive regulation of macrophage differentiation (GO:0045651)2.61686985
83mast cell degranulation (GO:0043303)2.61459269
84mast cell activation involved in immune response (GO:0002279)2.61459269
85myeloid leukocyte activation (GO:0002274)2.61006587
86cell adhesion mediated by integrin (GO:0033627)2.60642473
87lymphangiogenesis (GO:0001946)2.60530490
88cortical cytoskeleton organization (GO:0030865)2.59884627
89establishment of protein localization to Golgi (GO:0072600)2.59741638
90regulation of erythrocyte differentiation (GO:0045646)2.58119904
91establishment of nucleus localization (GO:0040023)2.57947877
92retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57932643
93embryonic camera-type eye morphogenesis (GO:0048596)2.57794185
94germ cell migration (GO:0008354)2.53160082
95interleukin-6-mediated signaling pathway (GO:0070102)2.52565133
96regulation of necroptotic process (GO:0060544)2.51708328
97positive regulation of cellular amide metabolic process (GO:0034250)2.50647361
98myeloid dendritic cell differentiation (GO:0043011)2.49910541
99I-kappaB phosphorylation (GO:0007252)2.47301113
100mature B cell differentiation involved in immune response (GO:0002313)2.46877631
101protein targeting to vacuole (GO:0006623)2.45837398
102protein targeting to lysosome (GO:0006622)2.45837398
103establishment of protein localization to vacuole (GO:0072666)2.45837398
104dendritic cell differentiation (GO:0097028)2.45215734
105positive regulation of chemokine secretion (GO:0090197)2.44262976
106regulation of Rap GTPase activity (GO:0032317)2.43838917
107activated T cell proliferation (GO:0050798)2.43686827
108response to host (GO:0075136)2.43665141
109response to host defenses (GO:0052200)2.43665141
110response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.43665141
111necroptotic process (GO:0070266)2.43603794
112response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.43492961
113response to host immune response (GO:0052572)2.43492961
114fusion of sperm to egg plasma membrane (GO:0007342)2.42927763
115platelet-derived growth factor receptor signaling pathway (GO:0048008)2.42424488
116embryonic hemopoiesis (GO:0035162)2.41696719
117insulin-like growth factor receptor signaling pathway (GO:0048009)2.41371793
118definitive hemopoiesis (GO:0060216)2.40046738
119leukocyte degranulation (GO:0043299)2.39667135
120defense response to protozoan (GO:0042832)2.39631009
121protein localization to lysosome (GO:0061462)2.39521715
122protein localization to vacuole (GO:0072665)2.39521715
123Golgi to endosome transport (GO:0006895)2.38846106
124nerve growth factor signaling pathway (GO:0038180)2.37227319
125thrombin receptor signaling pathway (GO:0070493)2.36518162
126artery development (GO:0060840)2.36286051
127regulation of protein glycosylation (GO:0060049)2.35953500
128peptidyl-threonine phosphorylation (GO:0018107)2.35544100
129myeloid cell development (GO:0061515)2.35434317
130positive regulation of granulocyte differentiation (GO:0030854)2.34334037
131positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.34020592
132regulation of pigment cell differentiation (GO:0050932)2.33430633
133glomerular basement membrane development (GO:0032836)2.33273409
134JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.33249936
135response to protozoan (GO:0001562)2.33220832
136leukocyte aggregation (GO:0070486)2.32343691
137positive regulation of lipid kinase activity (GO:0090218)2.31673200
138positive regulation of nitric-oxide synthase activity (GO:0051000)2.31129914
139Rap protein signal transduction (GO:0032486)2.30998428
140growth hormone receptor signaling pathway (GO:0060396)2.30012166
141embryonic foregut morphogenesis (GO:0048617)2.29598080
142cellular response to growth hormone stimulus (GO:0071378)2.28049924
143positive regulation of muscle hypertrophy (GO:0014742)2.27130436
144positive regulation of cardiac muscle hypertrophy (GO:0010613)2.27130436
145regulation of beta-amyloid formation (GO:1902003)2.26256528
146response to methylmercury (GO:0051597)2.23276855
147embryonic retina morphogenesis in camera-type eye (GO:0060059)2.22675382
148peptidyl-threonine modification (GO:0018210)2.22634095
149astrocyte differentiation (GO:0048708)2.22482582
150histone H3-K9 demethylation (GO:0033169)2.22011067
151protein targeting to Golgi (GO:0000042)2.21913804
152chondroitin sulfate catabolic process (GO:0030207)2.21482060
153negative regulation of protein oligomerization (GO:0032460)2.21152988
154regulation of establishment of cell polarity (GO:2000114)2.19787011
155blood vessel maturation (GO:0001955)2.18546972
156early endosome to late endosome transport (GO:0045022)2.16624099
157histone lysine demethylation (GO:0070076)2.16325423
158cytoskeletal anchoring at plasma membrane (GO:0007016)2.15729296
159regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.15111588
160cellular response to epinephrine stimulus (GO:0071872)2.13861696
161regulation of macrophage cytokine production (GO:0010935)2.12963715
162hypotonic response (GO:0006971)2.11671334
163positive regulation of T-helper cell differentiation (GO:0045624)2.10667451
164histone H3-K4 trimethylation (GO:0080182)2.09346737
165chondrocyte development (GO:0002063)2.08129873
166L-amino acid import (GO:0043092)2.05024699
167detection of molecule of bacterial origin (GO:0032490)2.03607047
168negative regulation of cytosolic calcium ion concentration (GO:0051481)2.03537814
169regulation of clathrin-mediated endocytosis (GO:2000369)2.03286721
170histone demethylation (GO:0016577)2.00108224
171regulation of inositol phosphate biosynthetic process (GO:0010919)1.98679410
172regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.97569267
173positive regulation of small GTPase mediated signal transduction (GO:0051057)1.97157665
174oligodendrocyte differentiation (GO:0048709)1.95340530
175regulation of platelet aggregation (GO:0090330)1.95254961
176regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)1.92988038
177pericardium development (GO:0060039)1.92072777
178regulation of Rac protein signal transduction (GO:0035020)1.91948029
179regulation of membrane lipid distribution (GO:0097035)1.91882160
180coronary vasculature morphogenesis (GO:0060977)1.91724072
181regulation of cardiac muscle hypertrophy (GO:0010611)1.91690325
182mitotic sister chromatid cohesion (GO:0007064)1.89458691
183keratan sulfate catabolic process (GO:0042340)1.89185033

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.32627872
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.95976235
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.83434028
4SCL_19346495_ChIP-Seq_HPC-7_Human3.78426310
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.58234009
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.54946825
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.53252964
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.49260523
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.19069456
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.13051267
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.96207575
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95567463
13RUNX_20019798_ChIP-Seq_JUKART_Human2.57712144
14SPI1_23127762_ChIP-Seq_K562_Human2.45633373
15* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.43718130
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.43063118
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41410378
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.36979584
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35720790
20* VDR_21846776_ChIP-Seq_THP-1_Human2.32221506
21* GBX2_23144817_ChIP-Seq_PC3_Human2.31881886
22* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.28467226
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27505114
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26000406
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.25468211
26* VDR_24763502_ChIP-Seq_THP-1_Human2.25181911
27* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24886716
28MYC_22102868_ChIP-Seq_BL_Human2.24410326
29CDX2_19796622_ChIP-Seq_MESCs_Mouse2.24185446
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.21026268
31* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14734468
32BRD4_27068464_Chip-Seq_AML-cells_Mouse2.14324197
33TCF7_22412390_ChIP-Seq_EML_Mouse2.03176413
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00159524
35MAF_26560356_Chip-Seq_TH1_Human1.91849421
36* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.90005374
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87655457
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.87613309
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.87445548
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86933301
41* MYB_26560356_Chip-Seq_TH2_Human1.86111796
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.84156387
43SPI1_23547873_ChIP-Seq_NB4_Human1.80942735
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.79903058
45MYB_26560356_Chip-Seq_TH1_Human1.79872108
46AHR_22903824_ChIP-Seq_MCF-7_Human1.74892558
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72834012
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71981988
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.71793434
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69685400
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.69401373
52GATA1_22025678_ChIP-Seq_K562_Human1.68384946
53NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.68081769
54IGF1R_20145208_ChIP-Seq_DFB_Human1.67578369
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.67308596
56PU_27001747_Chip-Seq_BMDM_Mouse1.66833338
57AR_21572438_ChIP-Seq_LNCaP_Human1.65780405
58* STAT3_23295773_ChIP-Seq_U87_Human1.64928493
59SMAD4_21799915_ChIP-Seq_A2780_Human1.64228364
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.63495823
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63477410
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.62439055
63* TP53_16413492_ChIP-PET_HCT116_Human1.61773496
64KDM2B_26808549_Chip-Seq_DND41_Human1.60398062
65* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.60123775
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59753169
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57788574
68* VDR_24787735_ChIP-Seq_THP-1_Human1.57700385
69* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55298195
70UTX_26944678_Chip-Seq_JUKART_Human1.47165558
71* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46980944
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46336950
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45012082
74GATA1_19941827_ChIP-Seq_MEL_Mouse1.44628584
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44514669
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44426019
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43615046
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39743567
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39690266
80GATA3_27048872_Chip-Seq_THYMUS_Human1.35185280
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35095723
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.34469829
83* TCF4_23295773_ChIP-Seq_U87_Human1.33973663
84* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33934263
85E2F7_22180533_ChIP-Seq_HELA_Human1.33036886
86EZH2_22144423_ChIP-Seq_EOC_Human1.32289386
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30004958
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30004958
89TAF15_26573619_Chip-Seq_HEK293_Human1.29819238
90NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.29732385
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29707594
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29671237
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28635441
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.27897142
95* BRD4_25478319_ChIP-Seq_HGPS_Human1.27459355
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26878638
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23458279
98DROSHA_22980978_ChIP-Seq_HELA_Human1.23111177
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22488954
100FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19131634
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17837159
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17678570
103SOX2_21211035_ChIP-Seq_LN229_Gbm1.16871657
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16217878
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.15551512
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15498414
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15486582
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13862375
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.12709386
110WT1_19549856_ChIP-ChIP_CCG9911_Human1.12487838
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10754453
112* GATA2_19941826_ChIP-Seq_K562_Human1.10696756
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09220214
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08998425
115GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08616178
116GATA3_26560356_Chip-Seq_TH2_Human1.08471773
117TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07363564
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.06666067
119* SMAD3_21741376_ChIP-Seq_EPCs_Human1.05305181
120* ER_23166858_ChIP-Seq_MCF-7_Human1.05011235
121GATA1_19941826_ChIP-Seq_K562_Human1.04213175
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02741645
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02449463
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.99566473
125FUS_26573619_Chip-Seq_HEK293_Human0.99076397
126* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98468335
127* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97920869
128CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97379669
129CJUN_26792858_Chip-Seq_BT549_Human0.97349998
130* AR_25329375_ChIP-Seq_VCAP_Human0.97152360
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96985117
132SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96490239
133* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96251150
134TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96242145
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95610456
136TCF4_18268006_ChIP-ChIP_LS174T_Human0.95359189
137* PRDM14_20953172_ChIP-Seq_ESCs_Human0.95294966
138* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95146298
139CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94760453
140FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94203911
141P53_22387025_ChIP-Seq_ESCs_Mouse0.94117859
142ELK3_25401928_ChIP-Seq_HUVEC_Human0.93608924
143KDM2B_26808549_Chip-Seq_REH_Human0.93399691
144* FOXA2_19822575_ChIP-Seq_HepG2_Human0.93094256
145* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92932939
146* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92158723
147NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85967997
148CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83266297
149MAF_26560356_Chip-Seq_TH2_Human0.82731169
150KDM2B_26808549_Chip-Seq_JURKAT_Human0.80699085
151* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79977271
152GATA3_26560356_Chip-Seq_TH1_Human0.79673678
153GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78494062
154TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77706577
155DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77689440
156CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77507543
157SPI1_20517297_ChIP-Seq_HL60_Human0.77259968
158* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76427022
159TBX20_22080862_ChIP-Seq_HEART_Mouse0.76051458
160TBX20_22328084_ChIP-Seq_HEART_Mouse0.76051458
161GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74955893
162LXR_22292898_ChIP-Seq_THP-1_Human0.74895585
163RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72904274
164EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.72679700
165SMRT_27268052_Chip-Seq_Bcells_Human0.72576547
166CIITA_25753668_ChIP-Seq_RAJI_Human0.72244538
167CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70932791
168ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69006274
169FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.68691869

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.67458026
2MP0001835_abnormal_antigen_presentation3.65114707
3MP0002396_abnormal_hematopoietic_system3.51073914
4MP0002009_preneoplasia3.25406985
5MP0003172_abnormal_lysosome_physiology2.99485005
6MP0003300_gastrointestinal_ulcer2.78189434
7MP0002419_abnormal_innate_immunity2.48249176
8MP0010386_abnormal_urinary_bladder2.46919379
9MP0000685_abnormal_immune_system2.39558543
10MP0005464_abnormal_platelet_physiology2.38399246
11MP0005387_immune_system_phenotype2.38215610
12MP0001790_abnormal_immune_system2.38215610
13MP0003303_peritoneal_inflammation2.37562879
14MP0001800_abnormal_humoral_immune2.37510226
15MP0004808_abnormal_hematopoietic_stem2.28853528
16MP0002452_abnormal_antigen_presenting2.25040296
17MP0005058_abnormal_lysosome_morphology2.23156195
18MP0003183_abnormal_peptide_metabolism2.22702536
19MP0005000_abnormal_immune_tolerance2.17486744
20MP0005174_abnormal_tail_pigmentation2.14065039
21MP0003690_abnormal_glial_cell2.13255483
22MP0002723_abnormal_immune_serum2.12540397
23MP0005671_abnormal_response_to2.12268071
24MP0003436_decreased_susceptibility_to2.08685571
25MP0000920_abnormal_myelination2.03391114
26MP0002420_abnormal_adaptive_immunity1.99549760
27MP0005397_hematopoietic_system_phenotyp1.99036805
28MP0001545_abnormal_hematopoietic_system1.99036805
29MP0001819_abnormal_immune_cell1.96854077
30MP0009278_abnormal_bone_marrow1.96486428
31MP0005025_abnormal_response_to1.94394491
32MP0009780_abnormal_chondrocyte_physiolo1.84341062
33MP0002166_altered_tumor_susceptibility1.82406412
34MP0000383_abnormal_hair_follicle1.81547716
35MP0005275_abnormal_skin_tensile1.80400196
36MP0002398_abnormal_bone_marrow1.78320225
37MP0002148_abnormal_hypersensitivity_rea1.76412635
38MP0004510_myositis1.73777340
39MP0010678_abnormal_skin_adnexa1.72326055
40MP0000716_abnormal_immune_system1.71184106
41MP0006082_CNS_inflammation1.66877449
42MP0003075_altered_response_to1.61301795
43MP0003191_abnormal_cellular_cholesterol1.58056801
44MP0003283_abnormal_digestive_organ1.53789310
45MP0000689_abnormal_spleen_morphology1.53231932
46MP0004270_analgesia1.48467267
47MP0001873_stomach_inflammation1.45325796
48MP0003045_fibrosis1.45008815
49MP0002405_respiratory_system_inflammati1.44793926
50MP0005167_abnormal_blood-brain_barrier1.43518115
51MP0001958_emphysema1.42782765
52MP0002429_abnormal_blood_cell1.41118591
53MP0005171_absent_coat_pigmentation1.40940636
54MP0009785_altered_susceptibility_to1.39981351
55MP0002127_abnormal_cardiovascular_syste1.38638667
56MP0005310_abnormal_salivary_gland1.38234599
57MP0001533_abnormal_skeleton_physiology1.38078701
58MP0002722_abnormal_immune_system1.35427491
59MP0004084_abnormal_cardiac_muscle1.33004256
60MP0003787_abnormal_imprinting1.32138712
61MP0000465_gastrointestinal_hemorrhage1.29693783
62MP0000604_amyloidosis1.29627984
63MP0001845_abnormal_inflammatory_respons1.29322630
64MP0009840_abnormal_foam_cell1.28800628
65MP0004947_skin_inflammation1.26219993
66MP0001879_abnormal_lymphatic_vessel1.26022166
67MP0005075_abnormal_melanosome_morpholog1.23529330
68MP0005646_abnormal_pituitary_gland1.23446436
69MP0002006_tumorigenesis1.21944543
70MP0003656_abnormal_erythrocyte_physiolo1.21521310
71MP0003868_abnormal_feces_composition1.20873738
72MP0002168_other_aberrant_phenotype1.20070612
73MP0003705_abnormal_hypodermis_morpholog1.18738881
74MP0001853_heart_inflammation1.18202603
75MP0010307_abnormal_tumor_latency1.14996637
76MP0002933_joint_inflammation1.14538748
77MP0002896_abnormal_bone_mineralization1.14132685
78MP0000343_altered_response_to1.13638453
79MP0003632_abnormal_nervous_system1.13349232
80MP0008469_abnormal_protein_level1.11699912
81MP0002998_abnormal_bone_remodeling1.10926596
82MP0000703_abnormal_thymus_morphology1.10603291
83MP0008961_abnormal_basal_metabolism1.08960405
84MP0001177_atelectasis1.08746211
85MP0010155_abnormal_intestine_physiology1.05206175
86MP0000015_abnormal_ear_pigmentation1.03666532
87MP0001851_eye_inflammation1.03536745
88MP0010234_abnormal_vibrissa_follicle1.00831192
89MP0003279_aneurysm1.00749279
90MP0001984_abnormal_olfaction1.00539683
91MP0005410_abnormal_fertilization1.00349329
92MP0003724_increased_susceptibility_to0.99365681
93MP0008438_abnormal_cutaneous_collagen0.98776200
94MP0005409_darkened_coat_color0.98570846
95MP0000639_abnormal_adrenal_gland0.98153922
96MP0003634_abnormal_glial_cell0.97608711
97MP0006054_spinal_hemorrhage0.96993572
98MP0010368_abnormal_lymphatic_system0.96056026
99MP0005595_abnormal_vascular_smooth0.95264100
100MP0003763_abnormal_thymus_physiology0.94705834
101MP0010352_gastrointestinal_tract_polyps0.94464114
102MP0008057_abnormal_DNA_replication0.93695248
103MP0003943_abnormal_hepatobiliary_system0.92679371
104MP0005166_decreased_susceptibility_to0.92114072
105MP0003252_abnormal_bile_duct0.90925280
106MP0003091_abnormal_cell_migration0.90886792
107MP0004859_abnormal_synaptic_plasticity0.90696517
108MP0004036_abnormal_muscle_relaxation0.90539854
109MP0001756_abnormal_urination0.90072003
110MP0002928_abnormal_bile_duct0.89586587
111MP0002095_abnormal_skin_pigmentation0.88134755
112MP0008004_abnormal_stomach_pH0.88071031
113MP0000371_diluted_coat_color0.86584883
114MP0002876_abnormal_thyroid_physiology0.85990415
115MP0003631_nervous_system_phenotype0.85878932
116MP0004272_abnormal_basement_membrane0.85437159
117MP0003950_abnormal_plasma_membrane0.84828145
118MP0004134_abnormal_chest_morphology0.84535211
119MP0005379_endocrine/exocrine_gland_phen0.83690703
120MP0004147_increased_porphyrin_level0.82910659
121MP0010329_abnormal_lipoprotein_level0.81671351
122MP0000249_abnormal_blood_vessel0.81669726
123MP0003828_pulmonary_edema0.80448897
124MP0005503_abnormal_tendon_morphology0.79802383
125MP0000767_abnormal_smooth_muscle0.79312858
126MP0002877_abnormal_melanocyte_morpholog0.79230259
127MP0000462_abnormal_digestive_system0.77322521
128MP0008874_decreased_physiological_sensi0.77004040
129MP0004130_abnormal_muscle_cell0.76672558
130MP0005164_abnormal_response_to0.76198838
131MP0002089_abnormal_postnatal_growth/wei0.74373115
132MP0009764_decreased_sensitivity_to0.74356020
133MP0004043_abnormal_pH_regulation0.73581801
134MP0004484_altered_response_of0.72961675
135MP0003880_abnormal_central_pattern0.72351883
136MP0003890_abnormal_embryonic-extraembry0.71861103
137MP0003566_abnormal_cell_adhesion0.70751451
138MP0005076_abnormal_cell_differentiation0.69106136
139MP0004883_abnormal_blood_vessel0.68914092
140MP0003448_altered_tumor_morphology0.68909292
141MP0009333_abnormal_splenocyte_physiolog0.68565767
142MP0005645_abnormal_hypothalamus_physiol0.68139376
143MP0003633_abnormal_nervous_system0.66929665
144MP0002133_abnormal_respiratory_system0.66897394
145MP0005388_respiratory_system_phenotype0.66897394
146MP0009763_increased_sensitivity_to0.66713961
147MP0005365_abnormal_bile_salt0.66532816
148MP0008775_abnormal_heart_ventricle0.66035709
149MP0005023_abnormal_wound_healing0.65523010
150MP0002060_abnormal_skin_morphology0.65368335
151MP0000427_abnormal_hair_cycle0.64672573
152MP0002909_abnormal_adrenal_gland0.64419214

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.51126447
2Recurrent bacterial skin infections (HP:0005406)4.45928732
3Spontaneous hematomas (HP:0007420)3.94987978
4Increased cerebral lipofuscin (HP:0011813)3.74819797
5Systemic lupus erythematosus (HP:0002725)3.68354893
6Papilledema (HP:0001085)3.62329723
7Chronic otitis media (HP:0000389)3.53611546
8Papillary thyroid carcinoma (HP:0002895)3.47708248
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.47384645
10Hematochezia (HP:0002573)3.42847050
11Cellulitis (HP:0100658)3.36087348
12Recurrent viral infections (HP:0004429)3.32752145
13Myositis (HP:0100614)3.28396050
14Eczematoid dermatitis (HP:0000976)3.25756153
15Colitis (HP:0002583)3.23456456
16Recurrent skin infections (HP:0001581)3.17584380
17Inflammation of the large intestine (HP:0002037)3.02667367
18Recurrent fungal infections (HP:0002841)3.02431872
19Macroorchidism (HP:0000053)2.95878166
20Elevated erythrocyte sedimentation rate (HP:0003565)2.95581700
21Disinhibition (HP:0000734)2.91782534
22Gastrointestinal inflammation (HP:0004386)2.90784199
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.86816582
24IgM deficiency (HP:0002850)2.84901584
25Recurrent gram-negative bacterial infections (HP:0005420)2.82799616
26Mediastinal lymphadenopathy (HP:0100721)2.82416869
27B lymphocytopenia (HP:0010976)2.82279573
28Abnormality of the fingertips (HP:0001211)2.81042153
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.73796024
30Thrombocytosis (HP:0001894)2.68964316
31Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.67876453
32Gingival bleeding (HP:0000225)2.65209963
33Abnormality of B cell number (HP:0010975)2.64686163
34Abnormality of the nasal mucosa (HP:0000433)2.62348171
35Overgrowth (HP:0001548)2.61869141
36Axonal loss (HP:0003447)2.61227501
37Acute myeloid leukemia (HP:0004808)2.58850501
38Interstitial pulmonary disease (HP:0006530)2.53847215
39Spinal cord lesions (HP:0100561)2.53840038
40Syringomyelia (HP:0003396)2.53840038
41Orchitis (HP:0100796)2.52921773
42Truncal obesity (HP:0001956)2.51766921
43Loss of speech (HP:0002371)2.51712266
44Hypoplasia of the thymus (HP:0000778)2.50672547
45Menstrual irregularities (HP:0000858)2.48714075
46Dysostosis multiplex (HP:0000943)2.48420322
47Pheochromocytoma (HP:0002666)2.47620518
48Spondylolisthesis (HP:0003302)2.47127878
49Abnormality of macrophages (HP:0004311)2.47005327
50Meningitis (HP:0001287)2.42574404
51Vasculitis (HP:0002633)2.40604825
52Cerebral aneurysm (HP:0004944)2.39825544
53Blue irides (HP:0000635)2.38656915
54Thyroid carcinoma (HP:0002890)2.35167783
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.34897349
56Agammaglobulinemia (HP:0004432)2.33249662
57Optic neuritis (HP:0100653)2.31785438
58Retrobulbar optic neuritis (HP:0100654)2.31785438
59Panhypogammaglobulinemia (HP:0003139)2.30619012
60Chronic mucocutaneous candidiasis (HP:0002728)2.30072747
61Recurrent cutaneous fungal infections (HP:0011370)2.30072747
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.29571328
63Osteolytic defects of the hand bones (HP:0009699)2.29571328
64Absent frontal sinuses (HP:0002688)2.28794685
65Recurrent bronchitis (HP:0002837)2.27967580
66Osteomyelitis (HP:0002754)2.27484535
67Broad metatarsal (HP:0001783)2.27302121
68Gastrointestinal stroma tumor (HP:0100723)2.25912328
69Testicular neoplasm (HP:0010788)2.24610396
70Abnormality of liposaccharide metabolism (HP:0010968)2.24608671
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.24608671
72Abnormality of glycolipid metabolism (HP:0010969)2.24608671
73Relative macrocephaly (HP:0004482)2.24516369
74Epistaxis (HP:0000421)2.21922080
75J-shaped sella turcica (HP:0002680)2.21459913
76Thickened calvaria (HP:0002684)2.20138978
77Prolonged bleeding time (HP:0003010)2.19297277
78Autoimmune thrombocytopenia (HP:0001973)2.17771727
79Abnormality of the thoracic spine (HP:0100711)2.17162609
80Arterial tortuosity (HP:0005116)2.14768836
81Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.12488489
82Thyroiditis (HP:0100646)2.10836169
83Arterial thrombosis (HP:0004420)2.10800822
84Coarse hair (HP:0002208)2.10769946
85Periodontitis (HP:0000704)2.10541840
86Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.09998369
87Thoracic kyphosis (HP:0002942)2.09454305
88Delayed closure of the anterior fontanelle (HP:0001476)2.08703013
89Nasal polyposis (HP:0100582)2.08341936
90Asymmetry of the thorax (HP:0001555)2.06409024
91Aortic aneurysm (HP:0004942)2.04783851
92Urinary glycosaminoglycan excretion (HP:0003541)2.04051942
93Mucopolysacchariduria (HP:0008155)2.04051942
94Volvulus (HP:0002580)2.04047765
95Vascular tortuosity (HP:0004948)2.03642664
96Chronic obstructive pulmonary disease (HP:0006510)2.01952525
97Obstructive lung disease (HP:0006536)2.01952525
98Cervical subluxation (HP:0003308)2.01772395
99Supranuclear gaze palsy (HP:0000605)2.01062126
100Aortic dissection (HP:0002647)2.00519766
101Agnosia (HP:0010524)1.99403431
102Mitral stenosis (HP:0001718)1.99249619
103T lymphocytopenia (HP:0005403)1.99144451
104Hyperacusis (HP:0010780)1.98537431
105Abnormal platelet function (HP:0011869)1.97772129
106Impaired platelet aggregation (HP:0003540)1.97772129
107Recurrent pneumonia (HP:0006532)1.97698475
108Polycythemia (HP:0001901)1.96835575
109Hyperventilation (HP:0002883)1.95948196
110Protrusio acetabuli (HP:0003179)1.95815480
111Vertebral arch anomaly (HP:0008438)1.95308013
112Petechiae (HP:0000967)1.95077960
113Inappropriate behavior (HP:0000719)1.94644493
114Broad face (HP:0000283)1.94614145
115Cranial hyperostosis (HP:0004437)1.94578098
116Neurofibrillary tangles (HP:0002185)1.94291422
117Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94179225
118Abnormality of polysaccharide metabolism (HP:0011012)1.94179225
119Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94179225
120Striae distensae (HP:0001065)1.93874235
121Pulmonary embolism (HP:0002204)1.93321422
122Myocardial infarction (HP:0001658)1.91379028
123Gingivitis (HP:0000230)1.89938322
124Glomerulonephritis (HP:0000099)1.89436119
125Hypoplasia of the iris (HP:0007676)1.89116520
126Narrow palate (HP:0000189)1.87589756
127Increased CSF protein (HP:0002922)1.86329520
128Pulmonary infiltrates (HP:0002113)1.86277643
129Disproportionate tall stature (HP:0001519)1.84564272
130Chest pain (HP:0100749)1.84331189
131Urethral obstruction (HP:0000796)1.84007239
132Genetic anticipation (HP:0003743)1.83848931
133Abnormality of the epiphyses of the hand (HP:0005924)1.83820079
134Restrictive lung disease (HP:0002091)1.82603588
135Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.82583945
136Slow saccadic eye movements (HP:0000514)1.82491046
137Acute lymphatic leukemia (HP:0006721)1.80376478
138Pulmonic stenosis (HP:0001642)1.79872121
139Degeneration of the lateral corticospinal tracts (HP:0002314)1.77762301
140Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77762301
141Metaphyseal dysplasia (HP:0100255)1.77093994
142Broad ribs (HP:0000885)1.75611592
143Curly hair (HP:0002212)1.74809301
144Neoplasm of the heart (HP:0100544)1.74083550
145Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.74047404
146Hemangiomatosis (HP:0007461)1.71270377
147Ankyloglossia (HP:0010296)1.68838352
148Craniofacial hyperostosis (HP:0004493)1.68745130
149Neuroendocrine neoplasm (HP:0100634)1.64093478
150Transitional cell carcinoma of the bladder (HP:0006740)1.62214599
151Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.60118018
152Abnormality of T cell number (HP:0011839)1.59813406
153Fibroma (HP:0010614)1.57684203
154Mild short stature (HP:0003502)1.57552833
155Fibrous tissue neoplasm (HP:0012316)1.56825638
156Ovoid vertebral bodies (HP:0003300)1.56643786
157Heterotopia (HP:0002282)1.56411860
158Visceral angiomatosis (HP:0100761)1.55191822
159Atrioventricular canal defect (HP:0006695)1.54734304
160Abnormality of oral frenula (HP:0000190)1.54151016
161Deep philtrum (HP:0002002)1.54104650
162Bladder neoplasm (HP:0009725)1.54094435
163Bladder carcinoma (HP:0002862)1.54094435
164Viral hepatitis (HP:0006562)1.53787260
165Dysmetric saccades (HP:0000641)1.52659518
166Germ cell neoplasia (HP:0100728)1.51048943
167Wormian bones (HP:0002645)1.49923308

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.31352973
2MAP4K13.55772098
3TAOK23.35086676
4KIT3.30397213
5CSF1R3.19172507
6FRK2.66661688
7EPHB12.48798735
8TAOK32.29472273
9NTRK32.17693268
10TGFBR12.12483339
11MAP3K22.05796578
12TYK21.92133357
13FES1.91614023
14BTK1.88897523
15CAMK1D1.88586537
16MAP2K61.86454447
17NEK91.84149115
18ITK1.79020916
19JAK11.76900568
20EEF2K1.72608268
21TBK11.66395069
22SYK1.65278432
23FLT31.64516806
24CAMK1G1.63896444
25BLK1.62835473
26CLK11.61818848
27STK101.61252520
28ERN11.59465536
29RIPK41.58865544
30AKT31.58653918
31SGK21.57584274
32CAMKK21.57347011
33ZAP701.55641601
34IRAK41.53473860
35PIK3CG1.51992454
36TEC1.48090396
37LRRK21.47055549
38PIK3CA1.36329395
39YES11.29883364
40STK391.24810877
41HCK1.23594120
42MAP3K51.22787013
43SCYL21.22258278
44PKN21.21530785
45DMPK1.18242062
46RIPK11.17422027
47PDGFRA1.17379967
48PRKD31.16503394
49MAP2K31.14359619
50NLK1.13497971
51TRPM71.10367030
52CAMKK11.09107547
53BMPR21.08209859
54MAP3K101.05575204
55PRPF4B1.03902660
56MAP3K141.01511073
57FGFR21.00668049
58JAK30.98881774
59CDK120.97489605
60MAPKAPK50.95884568
61LCK0.95289181
62DAPK20.93753715
63MAP3K130.93447699
64ICK0.92585043
65KSR20.92384979
66MELK0.92053653
67LYN0.91562018
68CCNB10.91169881
69BRD40.90671988
70FER0.87370649
71HIPK20.86951344
72PDK10.84886695
73IKBKB0.84621992
74TAOK10.84552245
75IKBKE0.84541616
76JAK20.81115076
77CAMK40.79695474
78MAPKAPK30.78428503
79SIK20.77859734
80SGK2230.77736237
81SGK4940.77736237
82PDGFRB0.77540036
83WNK40.76784693
84RPS6KB10.73799627
85MATK0.72360627
86TTN0.71302562
87MAPK110.70617281
88PASK0.68721216
89RPS6KB20.65958247
90PRKCQ0.65922783
91PAK20.65590916
92CDK190.65151903
93CSK0.64145725
94NTRK20.63617923
95SGK30.63518402
96MARK20.63487295
97PTK60.62885362
98RPS6KA40.62473025
99CSNK1A1L0.62283114
100PRKCH0.62193300
101EPHA30.61855405
102TXK0.61446577
103MTOR0.61327312
104FGFR40.60663376
105PKN10.60463010
106TNIK0.60098533
107CDK60.59232377
108PRKD10.58106901
109STK30.57993226
110PDPK10.57371308
111IRAK10.56672823
112WNK10.56486056
113RET0.55916535
114CAMK10.55665595
115PNCK0.53814228
116MAPK130.53733458
117MAP3K70.53633034
118RPS6KA20.53499101
119SIK10.51799953
120NEK60.50925116
121CHUK0.50603621
122EGFR0.50564742
123FYN0.49147997
124LATS10.49117845
125STK110.48927749
126PRKCE0.47107653
127INSRR0.46818293
128KSR10.46108610
129FGFR30.45396633
130SGK10.44055680
131PTK2B0.44041786
132MAP3K40.42788523
133MAP3K60.41217713
134TNK20.41076775
135RPS6KA60.40766137
136MAPK70.40634887
137GRK60.40031856
138BMX0.38701911
139MAPK150.37082671
140CDK30.36704553
141RPS6KC10.35077859
142RPS6KL10.35077859
143BMPR1B0.34436180
144MAPK120.32378157
145ATR0.32300758
146TRIB30.31864567

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.93287499
2Osteoclast differentiation_Homo sapiens_hsa043802.65773810
3Staphylococcus aureus infection_Homo sapiens_hsa051502.36870248
4Leishmaniasis_Homo sapiens_hsa051402.34542270
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.32737612
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.28828095
7Lysosome_Homo sapiens_hsa041421.78352954
8Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75468108
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.74997169
10Platelet activation_Homo sapiens_hsa046111.62461357
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62172862
12Tuberculosis_Homo sapiens_hsa051521.60262587
13Other glycan degradation_Homo sapiens_hsa005111.57469186
14Pertussis_Homo sapiens_hsa051331.55576550
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.54406730
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.48918865
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48015646
18Chemokine signaling pathway_Homo sapiens_hsa040621.47733958
19Chronic myeloid leukemia_Homo sapiens_hsa052201.44984950
20Toxoplasmosis_Homo sapiens_hsa051451.41215944
21Endometrial cancer_Homo sapiens_hsa052131.40716668
22Pancreatic cancer_Homo sapiens_hsa052121.37646209
23Acute myeloid leukemia_Homo sapiens_hsa052211.36681518
24Primary immunodeficiency_Homo sapiens_hsa053401.36213905
25Antigen processing and presentation_Homo sapiens_hsa046121.33438204
26Measles_Homo sapiens_hsa051621.33222801
27Hematopoietic cell lineage_Homo sapiens_hsa046401.31583464
28Shigellosis_Homo sapiens_hsa051311.27855692
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27641782
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.24158755
31GnRH signaling pathway_Homo sapiens_hsa049121.23549186
32Malaria_Homo sapiens_hsa051441.19954059
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19324398
34Choline metabolism in cancer_Homo sapiens_hsa052311.18821431
35Salmonella infection_Homo sapiens_hsa051321.17343804
36Non-small cell lung cancer_Homo sapiens_hsa052231.15771363
37Hepatitis B_Homo sapiens_hsa051611.14714236
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.12235207
39Asthma_Homo sapiens_hsa053101.08926777
40Prolactin signaling pathway_Homo sapiens_hsa049171.08823135
41Endocytosis_Homo sapiens_hsa041441.08134267
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.07910242
43ECM-receptor interaction_Homo sapiens_hsa045121.06923388
44T cell receptor signaling pathway_Homo sapiens_hsa046601.06619872
45Long-term potentiation_Homo sapiens_hsa047201.05977191
46Influenza A_Homo sapiens_hsa051641.05909000
47ABC transporters_Homo sapiens_hsa020101.01979910
48Lysine degradation_Homo sapiens_hsa003101.01945470
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01610090
50Complement and coagulation cascades_Homo sapiens_hsa046101.00512406
51Viral myocarditis_Homo sapiens_hsa054161.00507043
52Type II diabetes mellitus_Homo sapiens_hsa049301.00049372
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99339900
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.99041584
55Legionellosis_Homo sapiens_hsa051340.97752107
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96984551
57Phagosome_Homo sapiens_hsa041450.95112930
58FoxO signaling pathway_Homo sapiens_hsa040680.94238292
59Long-term depression_Homo sapiens_hsa047300.93576045
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93494216
61Prostate cancer_Homo sapiens_hsa052150.93368796
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91559464
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91149579
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90972204
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90912911
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86799668
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86387146
68Apoptosis_Homo sapiens_hsa042100.84825209
69Glioma_Homo sapiens_hsa052140.84623589
70Oxytocin signaling pathway_Homo sapiens_hsa049210.84247823
71VEGF signaling pathway_Homo sapiens_hsa043700.83120699
72MicroRNAs in cancer_Homo sapiens_hsa052060.81939544
73TNF signaling pathway_Homo sapiens_hsa046680.81451582
74Salivary secretion_Homo sapiens_hsa049700.80866363
75Inositol phosphate metabolism_Homo sapiens_hsa005620.80469643
76Circadian entrainment_Homo sapiens_hsa047130.80424129
77Herpes simplex infection_Homo sapiens_hsa051680.77710972
78Dilated cardiomyopathy_Homo sapiens_hsa054140.77040919
79Type I diabetes mellitus_Homo sapiens_hsa049400.76238994
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.75417704
81Gap junction_Homo sapiens_hsa045400.74448012
82Insulin secretion_Homo sapiens_hsa049110.72137820
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71945484
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71912649
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70967105
86Cholinergic synapse_Homo sapiens_hsa047250.70358903
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70181369
88Colorectal cancer_Homo sapiens_hsa052100.69959080
89African trypanosomiasis_Homo sapiens_hsa051430.69561415
90Amoebiasis_Homo sapiens_hsa051460.69362235
91Glutamatergic synapse_Homo sapiens_hsa047240.68326135
92Gastric acid secretion_Homo sapiens_hsa049710.68239415
93Renal cell carcinoma_Homo sapiens_hsa052110.68138349
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.68097219
95Insulin resistance_Homo sapiens_hsa049310.66280576
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66106644
97Sphingolipid metabolism_Homo sapiens_hsa006000.65502969
98MAPK signaling pathway_Homo sapiens_hsa040100.65100874
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64610284
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.64104185
101Thyroid hormone synthesis_Homo sapiens_hsa049180.62512920
102Autoimmune thyroid disease_Homo sapiens_hsa053200.61517568
103mTOR signaling pathway_Homo sapiens_hsa041500.61298009
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.61038003
105Adherens junction_Homo sapiens_hsa045200.60807255
106Melanoma_Homo sapiens_hsa052180.59193128
107Renin secretion_Homo sapiens_hsa049240.59162572
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58930640
109Pancreatic secretion_Homo sapiens_hsa049720.58666229
110Notch signaling pathway_Homo sapiens_hsa043300.58566515
111Focal adhesion_Homo sapiens_hsa045100.57317640
112Insulin signaling pathway_Homo sapiens_hsa049100.56520849
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56454506
114AMPK signaling pathway_Homo sapiens_hsa041520.56190557
115Ras signaling pathway_Homo sapiens_hsa040140.55945847
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55924789
117Graft-versus-host disease_Homo sapiens_hsa053320.55803023
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55128012
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54948596
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54296711
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52881628
122Dorso-ventral axis formation_Homo sapiens_hsa043200.52712004
123Rheumatoid arthritis_Homo sapiens_hsa053230.52573089
124Proteoglycans in cancer_Homo sapiens_hsa052050.52328018
125Olfactory transduction_Homo sapiens_hsa047400.51298993
126Caffeine metabolism_Homo sapiens_hsa002320.49823851
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48576054
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47971333
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47964115
130Rap1 signaling pathway_Homo sapiens_hsa040150.47657640
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45455483
132Allograft rejection_Homo sapiens_hsa053300.44973019
133cAMP signaling pathway_Homo sapiens_hsa040240.44940218
134Starch and sucrose metabolism_Homo sapiens_hsa005000.43804323
135Viral carcinogenesis_Homo sapiens_hsa052030.43298672
136Small cell lung cancer_Homo sapiens_hsa052220.39962778
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39903558
138Hepatitis C_Homo sapiens_hsa051600.38938741
139ErbB signaling pathway_Homo sapiens_hsa040120.38591440
140Estrogen signaling pathway_Homo sapiens_hsa049150.38337759

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