TBC1D8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)7.63657496
2cilium or flagellum-dependent cell motility (GO:0001539)6.04338266
3regulation of dendritic cell antigen processing and presentation (GO:0002604)5.51453606
4antigen processing and presentation of endogenous antigen (GO:0019883)5.36793340
5axonemal dynein complex assembly (GO:0070286)5.26281658
6growth hormone receptor signaling pathway (GO:0060396)5.25464163
7motile cilium assembly (GO:0044458)4.65486881
8positive regulation of antigen processing and presentation (GO:0002579)4.58450047
9cellular response to growth hormone stimulus (GO:0071378)4.50291879
10regulation of RIG-I signaling pathway (GO:0039535)4.44845805
11myeloid dendritic cell differentiation (GO:0043011)4.38066257
12positive regulation of natural killer cell differentiation (GO:0032825)4.36087922
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.16965646
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.16965646
15regulation of T-helper 1 cell differentiation (GO:0045625)4.11470393
16negative regulation of humoral immune response (GO:0002921)4.09598407
17T-helper 1 type immune response (GO:0042088)4.07272038
18regulation of hypersensitivity (GO:0002883)3.98448405
19cilium movement (GO:0003341)3.95838064
20dendritic cell differentiation (GO:0097028)3.89427068
21regulation of interleukin-12 biosynthetic process (GO:0045075)3.85510239
22necroptotic process (GO:0070266)3.84472701
23positive regulation of interleukin-12 production (GO:0032735)3.83138729
24myeloid dendritic cell activation (GO:0001773)3.79031331
25negative regulation of protein activation cascade (GO:2000258)3.78347338
26neutrophil activation involved in immune response (GO:0002283)3.77203834
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.75122585
28regulation of antigen processing and presentation (GO:0002577)3.73128966
29regulation of complement activation (GO:0030449)3.72618890
30negative regulation of complement activation (GO:0045916)3.71286734
31natural killer cell mediated cytotoxicity (GO:0042267)3.70353222
32natural killer cell mediated immunity (GO:0002228)3.70353222
33regulation of protein activation cascade (GO:2000257)3.67392139
34neutrophil activation (GO:0042119)3.66142188
35leukocyte mediated cytotoxicity (GO:0001909)3.48056689
36regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.43057766
37regulation of natural killer cell differentiation (GO:0032823)3.41241967
38granulocyte activation (GO:0036230)3.40378837
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.40363374
40regulation of apoptotic cell clearance (GO:2000425)3.35784587
41response to muramyl dipeptide (GO:0032495)3.35746701
42antigen processing and presentation via MHC class Ib (GO:0002475)3.32015121
43protein carboxylation (GO:0018214)3.28602618
44peptidyl-glutamic acid carboxylation (GO:0017187)3.28602618
45CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.23918662
46T-helper cell differentiation (GO:0042093)3.23918662
47interferon-gamma-mediated signaling pathway (GO:0060333)3.18871712
48negative regulation of fibrinolysis (GO:0051918)3.18558594
49negative thymic T cell selection (GO:0045060)3.17022243
50positive regulation of T-helper cell differentiation (GO:0045624)3.15411729
51JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.15334605
52cellular response to ethanol (GO:0071361)3.13976358
53carnitine transmembrane transport (GO:1902603)3.11937589
54regulation of skeletal muscle contraction (GO:0014819)3.11291762
55positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.09705629
56production of molecular mediator involved in inflammatory response (GO:0002532)3.09249734
57regulation of MHC class I biosynthetic process (GO:0045343)3.05744724
58regulation of interferon-beta biosynthetic process (GO:0045357)3.05307848
59myeloid leukocyte mediated immunity (GO:0002444)3.02425858
60response to peptidoglycan (GO:0032494)3.00638657
61skeletal muscle adaptation (GO:0043501)2.99660527
62immunoglobulin mediated immune response (GO:0016064)2.98466334
63cytokine secretion (GO:0050663)2.97550995
64ethanol metabolic process (GO:0006067)2.96654683
65positive regulation of cholesterol efflux (GO:0010875)2.96423938
66intestinal cholesterol absorption (GO:0030299)2.95034007
67regulation of necroptotic process (GO:0060544)2.94816110
68positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.94372519
69regulation of T cell tolerance induction (GO:0002664)2.94024967
70positive regulation of granulocyte chemotaxis (GO:0071624)2.93706656
71positive regulation of extracellular matrix organization (GO:1903055)2.93570768
72positive regulation of natural killer cell activation (GO:0032816)2.92465695
73carnitine transport (GO:0015879)2.92424026
74amino-acid betaine transport (GO:0015838)2.92424026
75positive regulation of type 2 immune response (GO:0002830)2.90586601
76positive regulation of glycoprotein biosynthetic process (GO:0010560)2.90527185
77adenosine receptor signaling pathway (GO:0001973)2.90512932
78regulation of interleukin-12 production (GO:0032655)2.90224848
79negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.89957677
80iron ion import (GO:0097286)2.89489203
81epithelial cilium movement (GO:0003351)2.87692174
82axoneme assembly (GO:0035082)2.87483129
83cell killing (GO:0001906)2.86911544
84programmed necrotic cell death (GO:0097300)2.86303051
85regulation of T-helper 2 cell differentiation (GO:0045628)2.85393697
86response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.85227258
87macroautophagy (GO:0016236)2.84763296
88killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.83920785
89disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.83920785
90vitamin transmembrane transport (GO:0035461)2.83563865
91positive regulation of humoral immune response (GO:0002922)2.83504894
92negative T cell selection (GO:0043383)2.81981981
93primary alcohol catabolic process (GO:0034310)2.81672655
94positive regulation of neutrophil migration (GO:1902624)2.80792230
95positive regulation of neutrophil chemotaxis (GO:0090023)2.80792230
96regulation of activation of Janus kinase activity (GO:0010533)2.78429442
97response to fungus (GO:0009620)2.78260516
98ethanol oxidation (GO:0006069)2.76715104
99very-low-density lipoprotein particle assembly (GO:0034379)2.76131429
100type I interferon signaling pathway (GO:0060337)2.75736839
101cellular response to type I interferon (GO:0071357)2.75736839
102striated muscle atrophy (GO:0014891)2.75481535
103positive regulation of cholesterol transport (GO:0032376)2.75250886
104positive regulation of sterol transport (GO:0032373)2.75250886
105positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.74816652
106necrotic cell death (GO:0070265)2.74648126
107response to type I interferon (GO:0034340)2.73970006
108positive regulation of interferon-alpha production (GO:0032727)2.73575927
109lung epithelium development (GO:0060428)2.73206239
110positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71179483
111skeletal muscle contraction (GO:0003009)2.71095324
112neutrophil mediated immunity (GO:0002446)2.69890517
113positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.69863596
114regulation of fibrinolysis (GO:0051917)2.69316874
115dendritic cell migration (GO:0036336)2.67354945
116quaternary ammonium group transport (GO:0015697)2.67088998
117negative regulation of necroptotic process (GO:0060546)2.66905837
118T cell differentiation involved in immune response (GO:0002292)2.66622072
119alpha-beta T cell differentiation involved in immune response (GO:0002293)2.66622072
120alpha-beta T cell activation involved in immune response (GO:0002287)2.66622072
121glomerular epithelial cell development (GO:0072310)2.66609939
122hypotonic response (GO:0006971)2.66511523
123sarcoplasmic reticulum calcium ion transport (GO:0070296)2.65432131
124cholesterol efflux (GO:0033344)2.65037961
125carnitine shuttle (GO:0006853)2.64538903
126regulation of cellular extravasation (GO:0002691)2.64135442
127regulation of natural killer cell activation (GO:0032814)2.63740338
128myofibril assembly (GO:0030239)2.63591343
129mature B cell differentiation (GO:0002335)2.63172226
130complement activation, alternative pathway (GO:0006957)2.61167481
131dendritic cell chemotaxis (GO:0002407)2.60421698
132positive regulation of gamma-delta T cell activation (GO:0046645)2.59951972
133hydrogen peroxide biosynthetic process (GO:0050665)2.59719426
134negative regulation of immunoglobulin mediated immune response (GO:0002890)2.59405527
135negative regulation of B cell mediated immunity (GO:0002713)2.59405527
136adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.59286548
137T cell activation involved in immune response (GO:0002286)2.58099652
138positive regulation of Cdc42 GTPase activity (GO:0043089)2.57574940
139lymphocyte mediated immunity (GO:0002449)2.57260154
140plasma lipoprotein particle assembly (GO:0034377)2.56974369
141interferon-gamma secretion (GO:0072643)2.56493397
142positive regulation of p38MAPK cascade (GO:1900745)2.56239304
143low-density lipoprotein particle remodeling (GO:0034374)2.55256963
144positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.53535028
145positive regulation of macrophage cytokine production (GO:0060907)2.52031853
146positive regulation of cellular amide metabolic process (GO:0034250)2.50283350
147negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.49903450
148regulation of interferon-alpha production (GO:0032647)2.49886551
149detection of molecule of bacterial origin (GO:0032490)2.49672605
150negative regulation of cell killing (GO:0031342)2.49592986
151protein-lipid complex assembly (GO:0065005)2.48614588
152positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.48428446
153regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.47222469
154fatty acid transmembrane transport (GO:1902001)2.47091223
155protein-lipid complex remodeling (GO:0034368)2.46211356
156macromolecular complex remodeling (GO:0034367)2.46211356
157plasma lipoprotein particle remodeling (GO:0034369)2.46211356
158germinal center formation (GO:0002467)2.43660393
159regulation of humoral immune response (GO:0002920)2.40931841
160diterpenoid biosynthetic process (GO:0016102)2.40484769
161dicarboxylic acid biosynthetic process (GO:0043650)2.40227576
162regulation of alkaline phosphatase activity (GO:0010692)2.39698321
163plasma lipoprotein particle organization (GO:0071827)2.39171792
164protein-lipid complex subunit organization (GO:0071825)2.35690856
165cellular response to thyroid hormone stimulus (GO:0097067)2.35665436
166interkinetic nuclear migration (GO:0022027)2.32948066
167high-density lipoprotein particle remodeling (GO:0034375)2.31225640
168muscle atrophy (GO:0014889)2.30655143
169regulation of cholesterol homeostasis (GO:2000188)2.29771924
170positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.29351158
171acute-phase response (GO:0006953)2.28656215
172oligosaccharide catabolic process (GO:0009313)2.28389446
173actin-myosin filament sliding (GO:0033275)2.27579886
174muscle filament sliding (GO:0030049)2.27579886
175response to muscle activity (GO:0014850)2.26494356
176fibrinolysis (GO:0042730)2.26475229
177desmosome organization (GO:0002934)2.25848336
178regulation of germinal center formation (GO:0002634)2.25841924
179regulation of membrane protein ectodomain proteolysis (GO:0051043)2.25541192
180cardiac myofibril assembly (GO:0055003)2.24946277
181pyrimidine-containing compound transmembrane transport (GO:0072531)2.21719764
182lipoprotein metabolic process (GO:0042157)2.20860092
183flavonoid metabolic process (GO:0009812)2.19306018
184positive regulation of hemostasis (GO:1900048)2.19022287
185positive regulation of blood coagulation (GO:0030194)2.19022287
186sarcomere organization (GO:0045214)2.17834839
187glycogen catabolic process (GO:0005980)2.16769264
188reverse cholesterol transport (GO:0043691)2.16708696
189positive regulation of coagulation (GO:0050820)2.16637717
190plasma lipoprotein particle clearance (GO:0034381)2.15361592
191mannose metabolic process (GO:0006013)2.14615163
192pinocytosis (GO:0006907)2.13001806
193negative regulation of TOR signaling (GO:0032007)2.12407101
194positive regulation of chemokine secretion (GO:0090197)2.10669078
195regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.10584902
196phospholipid efflux (GO:0033700)2.10536664
197regulation of chemokine secretion (GO:0090196)2.10260980
198exogenous drug catabolic process (GO:0042738)2.09498642
199drug catabolic process (GO:0042737)2.07953841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.22077739
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.00861249
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.21732160
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.16449931
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.09853849
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.07081233
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.05265740
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.03045397
9GATA1_22025678_ChIP-Seq_K562_Human3.02648444
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.97663707
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.80340064
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69386650
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42373598
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41321151
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.39663944
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.36475340
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.34233453
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.30061035
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18830818
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10601602
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10296361
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.07602346
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92096614
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.91245163
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90921488
26* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90347579
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.77893708
28VDR_24787735_ChIP-Seq_THP-1_Human1.77374206
29CTNNB1_20460455_ChIP-Seq_HCT116_Human1.72635947
30* TCF7_22412390_ChIP-Seq_EML_Mouse1.66829166
31* AHR_22903824_ChIP-Seq_MCF-7_Human1.63414092
32RUNX_20019798_ChIP-Seq_JUKART_Human1.62039803
33* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59414593
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58664269
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.58242335
36* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54082153
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.53325007
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.51254825
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48677745
40SPI1_23127762_ChIP-Seq_K562_Human1.46160402
41MAF_26560356_Chip-Seq_TH1_Human1.45994456
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44604667
43* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.44062768
44* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44038163
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39215052
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.37444548
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.37444548
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.35318770
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35106610
50* ARNT_22903824_ChIP-Seq_MCF-7_Human1.31778561
51* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31135373
52VDR_24763502_ChIP-Seq_THP-1_Human1.31085262
53NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31070373
54E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30623614
55KDM2B_26808549_Chip-Seq_K562_Human1.26211718
56* HNF4A_19822575_ChIP-Seq_HepG2_Human1.25962612
57* PU_27001747_Chip-Seq_BMDM_Mouse1.25906386
58MYB_26560356_Chip-Seq_TH2_Human1.25647566
59KDM2B_26808549_Chip-Seq_DND41_Human1.24836521
60SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23169412
61SCL_19346495_ChIP-Seq_HPC-7_Human1.22880483
62MYB_26560356_Chip-Seq_TH1_Human1.22705797
63GATA4_25053715_ChIP-Seq_YYC3_Human1.22129884
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.22011039
65FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21433302
66TP53_16413492_ChIP-PET_HCT116_Human1.19778912
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19125209
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17185981
69SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17185981
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16687165
71P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15910578
72GATA3_27048872_Chip-Seq_THYMUS_Human1.15868853
73* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15808047
74SOX2_20726797_ChIP-Seq_SW620_Human1.14307104
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13057574
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13041180
77* EP300_21415370_ChIP-Seq_HL-1_Mouse1.12733970
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12509392
79* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.11510333
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.10916643
81* LXR_22158963_ChIP-Seq_LIVER_Mouse1.09599635
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08598702
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.08329050
84GATA6_25053715_ChIP-Seq_YYC3_Human1.08223983
85* GATA1_19941827_ChIP-Seq_MEL_Mouse1.07681249
86VDR_21846776_ChIP-Seq_THP-1_Human1.07427891
87SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06511685
88* RACK7_27058665_Chip-Seq_MCF-7_Human1.04905915
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.04784741
90GATA3_26560356_Chip-Seq_TH2_Human1.02821543
91* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02816540
92GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02225895
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02058469
94* CJUN_26792858_Chip-Seq_BT549_Human1.01604869
95* SPI1_23547873_ChIP-Seq_NB4_Human1.01524492
96RXR_22158963_ChIP-Seq_LIVER_Mouse1.01043676
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00941969
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00008612
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.98370059
100* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97741069
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97453437
102KDM2B_26808549_Chip-Seq_JURKAT_Human0.96151245
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96041049
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95681377
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95446600
106NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93506457
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93506457
108* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92372179
109* SMRT_27268052_Chip-Seq_Bcells_Human0.92035711
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91510186
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.90677243
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.89724171
113FOXA1_25552417_ChIP-Seq_VCAP_Human0.88954976
114PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88815698
115KLF5_25053715_ChIP-Seq_YYC3_Human0.88677146
116GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88218622
117GATA1_19941826_ChIP-Seq_K562_Human0.88034655
118* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88019994
119* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87987076
120EGR1_19032775_ChIP-ChIP_M12_Human0.87388346
121ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.86978034
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86412630
123TCF4_18268006_ChIP-ChIP_LS174T_Human0.86194121
124* FOXA2_19822575_ChIP-Seq_HepG2_Human0.86015087
125AR_21572438_ChIP-Seq_LNCaP_Human0.85361375
126DROSHA_22980978_ChIP-Seq_HELA_Human0.84795069
127STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84092299
128RUNX1_22412390_ChIP-Seq_EML_Mouse0.82460570
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82319002
130UTX_26944678_Chip-Seq_JUKART_Human0.82201378
131* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81403570
132GATA2_19941826_ChIP-Seq_K562_Human0.80869954
133RXR_22108803_ChIP-Seq_LS180_Human0.79223732
134GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77925540
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76717693
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76639622
137RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.74703563
138ELK3_25401928_ChIP-Seq_HUVEC_Human0.74507875
139GATA2_22383799_ChIP-Seq_G1ME_Mouse0.72919805
140VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.71860747
141* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71549318
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71538948
143* TP63_23658742_ChIP-Seq_EP156T_Human0.71299858
144* RUNX1_27514584_Chip-Seq_MCF-7_Human0.70897903
145EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.70506277
146CDX2_19796622_ChIP-Seq_MESCs_Mouse0.70198385
147KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.69771096
148* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69731401

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.06533542
2MP0002138_abnormal_hepatobiliary_system5.22554059
3MP0001835_abnormal_antigen_presentation4.12875378
4MP0002139_abnormal_hepatobiliary_system3.51281781
5MP0000685_abnormal_immune_system3.41264861
6MP0004510_myositis3.33353792
7MP0000569_abnormal_digit_pigmentation3.27423038
8MP0001348_abnormal_lacrimal_gland3.04023806
9MP0008875_abnormal_xenobiotic_pharmacok3.02028070
10MP0005310_abnormal_salivary_gland2.97495205
11MP0001346_abnormal_lacrimal_gland2.80739859
12MP0003195_calcinosis2.78907559
13MP0005451_abnormal_body_composition2.77021286
14MP0002877_abnormal_melanocyte_morpholog2.64755639
15MP0002166_altered_tumor_susceptibility2.61972478
16MP0003646_muscle_fatigue2.54562694
17MP0003436_decreased_susceptibility_to2.53307523
18MP0002148_abnormal_hypersensitivity_rea2.46324490
19MP0005387_immune_system_phenotype2.26628029
20MP0001790_abnormal_immune_system2.26628029
21MP0001873_stomach_inflammation2.25033057
22MP0000751_myopathy2.22255919
23MP0004036_abnormal_muscle_relaxation2.21844236
24MP0002009_preneoplasia2.19707637
25MP0003303_peritoneal_inflammation2.19196723
26MP0009785_altered_susceptibility_to2.16504377
27MP0004084_abnormal_cardiac_muscle2.15066166
28MP0003950_abnormal_plasma_membrane2.10357773
29MP0002006_tumorigenesis2.02231601
30MP0002419_abnormal_innate_immunity2.01583412
31MP0009780_abnormal_chondrocyte_physiolo2.00737631
32MP0003828_pulmonary_edema1.98754180
33MP0002163_abnormal_gland_morphology1.96305139
34MP0003183_abnormal_peptide_metabolism1.93380409
35MP0004130_abnormal_muscle_cell1.91622975
36MP0003656_abnormal_erythrocyte_physiolo1.90280318
37MP0005671_abnormal_response_to1.88748866
38MP0005000_abnormal_immune_tolerance1.84413744
39MP0001800_abnormal_humoral_immune1.84398050
40MP0004043_abnormal_pH_regulation1.83973027
41MP0005330_cardiomyopathy1.82052112
42MP0005025_abnormal_response_to1.81424354
43MP0002332_abnormal_exercise_endurance1.80712332
44MP0002452_abnormal_antigen_presenting1.73907594
45MP0002277_abnormal_respiratory_mucosa1.72028544
46MP0000749_muscle_degeneration1.67527444
47MP0002723_abnormal_immune_serum1.66501996
48MP0002132_abnormal_respiratory_system1.64418419
49MP0010234_abnormal_vibrissa_follicle1.63310736
50MP0002168_other_aberrant_phenotype1.62672057
51MP0001819_abnormal_immune_cell1.57691428
52MP0001881_abnormal_mammary_gland1.57163273
53MP0004233_abnormal_muscle_weight1.53695815
54MP0005670_abnormal_white_adipose1.53364684
55MP0003172_abnormal_lysosome_physiology1.53019986
56MP0003300_gastrointestinal_ulcer1.52944760
57MP0002420_abnormal_adaptive_immunity1.52566997
58MP0004087_abnormal_muscle_fiber1.47973701
59MP0002876_abnormal_thyroid_physiology1.47283208
60MP0001666_abnormal_nutrient_absorption1.45915761
61MP0010329_abnormal_lipoprotein_level1.39207106
62MP0009764_decreased_sensitivity_to1.36166936
63MP0010155_abnormal_intestine_physiology1.36152630
64MP0005464_abnormal_platelet_physiology1.35509264
65MP0010368_abnormal_lymphatic_system1.33400488
66MP0009840_abnormal_foam_cell1.31916635
67MP0003045_fibrosis1.31128617
68MP0000747_muscle_weakness1.31086663
69MP0002405_respiratory_system_inflammati1.30638266
70MP0003191_abnormal_cellular_cholesterol1.30574135
71MP0005379_endocrine/exocrine_gland_phen1.29813654
72MP0005360_urolithiasis1.27904157
73MP0004484_altered_response_of1.26320722
74MP0005174_abnormal_tail_pigmentation1.26084421
75MP0002822_catalepsy1.25592455
76MP0005058_abnormal_lysosome_morphology1.25193093
77MP0005409_darkened_coat_color1.22314605
78MP0001853_heart_inflammation1.21245586
79MP0001845_abnormal_inflammatory_respons1.20942003
80MP0002269_muscular_atrophy1.20707080
81MP0005551_abnormal_eye_electrophysiolog1.20355180
82MP0003252_abnormal_bile_duct1.20241475
83MP0003011_delayed_dark_adaptation1.19876902
84MP0000716_abnormal_immune_system1.18984598
85MP0003566_abnormal_cell_adhesion1.18635233
86MP0005164_abnormal_response_to1.18526339
87MP0001661_extended_life_span1.18291437
88MP0003075_altered_response_to1.17730601
89MP0004947_skin_inflammation1.16756856
90MP0010678_abnormal_skin_adnexa1.16561473
91MP0002837_dystrophic_cardiac_calcinosis1.15079586
92MP0002106_abnormal_muscle_physiology1.14563607
93MP0003453_abnormal_keratinocyte_physiol1.14074579
94MP0002118_abnormal_lipid_homeostasis1.13356572
95MP0006138_congestive_heart_failure1.12780323
96MP0004145_abnormal_muscle_electrophysio1.11678014
97MP0010630_abnormal_cardiac_muscle1.11273570
98MP0000383_abnormal_hair_follicle1.10619814
99MP0003724_increased_susceptibility_to1.10263914
100MP0005076_abnormal_cell_differentiation1.10036801
101MP0002971_abnormal_brown_adipose1.08854573
102MP0002972_abnormal_cardiac_muscle1.08829251
103MP0002928_abnormal_bile_duct1.08437939
104MP0002398_abnormal_bone_marrow1.08229976
105MP0002998_abnormal_bone_remodeling1.02182848
106MP0003879_abnormal_hair_cell1.01258117
107MP0005397_hematopoietic_system_phenotyp1.00253990
108MP0001545_abnormal_hematopoietic_system1.00253990
109MP0001533_abnormal_skeleton_physiology0.99638519
110MP0004215_abnormal_myocardial_fiber0.98614467
111MP0005620_abnormal_muscle_contractility0.97201606
112MP0005375_adipose_tissue_phenotype0.96474150
113MP0001756_abnormal_urination0.96126646
114MP0004782_abnormal_surfactant_physiolog0.95697967
115MP0002693_abnormal_pancreas_physiology0.95531799
116MP0005666_abnormal_adipose_tissue0.94688424
117MP0009278_abnormal_bone_marrow0.93680034
118MP0005083_abnormal_biliary_tract0.93135939
119MP0000609_abnormal_liver_physiology0.91546178
120MP0008260_abnormal_autophagy0.91300208
121MP0008469_abnormal_protein_level0.90741919
122MP0006082_CNS_inflammation0.90714881
123MP0000759_abnormal_skeletal_muscle0.89219205
124MP0000013_abnormal_adipose_tissue0.89081203
125MP0004883_abnormal_blood_vessel0.88638726
126MP0005332_abnormal_amino_acid0.87753329
127MP0003448_altered_tumor_morphology0.86002299
128MP0000003_abnormal_adipose_tissue0.85966754
129MP0002429_abnormal_blood_cell0.85827332
130MP0005023_abnormal_wound_healing0.85311356
131MP0005165_increased_susceptibility_to0.84730580
132MP0003868_abnormal_feces_composition0.84660019
133MP0004019_abnormal_vitamin_homeostasis0.84380784
134MP0003690_abnormal_glial_cell0.84315940
135MP0009643_abnormal_urine_homeostasis0.84209355
136MP0005376_homeostasis/metabolism_phenot0.83833538
137MP0009115_abnormal_fat_cell0.83750032
138MP0005085_abnormal_gallbladder_physiolo0.83628668
139MP0005369_muscle_phenotype0.82154462
140MP0000604_amyloidosis0.82060213
141MP0002090_abnormal_vision0.82051948
142MP0001851_eye_inflammation0.81684630
143MP0001765_abnormal_ion_homeostasis0.81409800
144MP0005319_abnormal_enzyme/_coenzyme0.81316842
145MP0005167_abnormal_blood-brain_barrier0.80819276
146MP0001879_abnormal_lymphatic_vessel0.80439720
147MP0006054_spinal_hemorrhage0.79974985
148MP0005266_abnormal_metabolism0.79344935
149MP0008872_abnormal_physiological_respon0.78155241
150MP0003763_abnormal_thymus_physiology0.78110284
151MP0010352_gastrointestinal_tract_polyps0.75140767
152MP0000371_diluted_coat_color0.70094731
153MP0003787_abnormal_imprinting0.69726024
154MP0002722_abnormal_immune_system0.69414589
155MP0005365_abnormal_bile_salt0.65557834
156MP0004264_abnormal_extraembryonic_tissu0.64409935
157MP0000689_abnormal_spleen_morphology0.63774462
158MP0000858_altered_metastatic_potential0.63441274
159MP0000767_abnormal_smooth_muscle0.62705224
160MP0010307_abnormal_tumor_latency0.61338770
161MP0005253_abnormal_eye_physiology0.60545355
162MP0000627_abnormal_mammary_gland0.58686913
163MP0003091_abnormal_cell_migration0.58150114
164MP0009765_abnormal_xenobiotic_induced0.57177357
165MP0004808_abnormal_hematopoietic_stem0.56645529
166MP0002909_abnormal_adrenal_gland0.56418671
167MP0005084_abnormal_gallbladder_morpholo0.55820484
168MP0003705_abnormal_hypodermis_morpholog0.55788807
169MP0000249_abnormal_blood_vessel0.54118715
170MP0001663_abnormal_digestive_system0.53955281

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.97072475
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.61896235
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.36295759
4Absent/shortened dynein arms (HP:0200106)5.36295759
5Recurrent bacterial skin infections (HP:0005406)5.20973141
6Abnormal ciliary motility (HP:0012262)5.16574567
7Abnormal respiratory motile cilium morphology (HP:0005938)5.12809581
8Abnormal respiratory epithelium morphology (HP:0012253)5.12809581
9Abnormal respiratory motile cilium physiology (HP:0012261)5.01319630
10Recurrent abscess formation (HP:0002722)4.86096503
11Recurrent fungal infections (HP:0002841)4.81390161
12Rhinitis (HP:0012384)4.61949607
13Recurrent gram-negative bacterial infections (HP:0005420)4.55743336
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.28596806
15Colitis (HP:0002583)4.25055317
16Recurrent cutaneous fungal infections (HP:0011370)4.16517866
17Chronic mucocutaneous candidiasis (HP:0002728)4.16517866
18Deep venous thrombosis (HP:0002625)4.07892412
19Congenital stationary night blindness (HP:0007642)4.06560777
20Increased IgE level (HP:0003212)3.94607009
21Chronic bronchitis (HP:0004469)3.91084846
22Autoimmune thrombocytopenia (HP:0001973)3.87824406
23Recurrent skin infections (HP:0001581)3.81680216
24Recurrent viral infections (HP:0004429)3.78190527
25Mediastinal lymphadenopathy (HP:0100721)3.77230369
26Fatigue (HP:0012378)3.75409879
27Periodontitis (HP:0000704)3.64566923
28Myocardial infarction (HP:0001658)3.63358957
29Hematochezia (HP:0002573)3.57352219
30Myositis (HP:0100614)3.57287478
31Pigmentary retinal degeneration (HP:0001146)3.55550591
32Orchitis (HP:0100796)3.54498478
33Bronchiectasis (HP:0002110)3.52100461
34Exercise-induced myalgia (HP:0003738)3.49783675
35Retrobulbar optic neuritis (HP:0100654)3.44792642
36Optic neuritis (HP:0100653)3.44792642
37Inflammation of the large intestine (HP:0002037)3.31711884
38Gingivitis (HP:0000230)3.31313253
39Prolonged partial thromboplastin time (HP:0003645)3.29276418
40Abnormality of macrophages (HP:0004311)3.21905081
41Hemorrhage of the eye (HP:0011885)3.21658959
42Bony spicule pigmentary retinopathy (HP:0007737)3.19697073
43Polycythemia (HP:0001901)3.18795302
44Muscle fiber inclusion bodies (HP:0100299)3.18624238
45Arterial thrombosis (HP:0004420)3.18281835
46Nemaline bodies (HP:0003798)3.16596250
47Joint hemorrhage (HP:0005261)3.14794102
48Interstitial pulmonary disease (HP:0006530)3.14013230
49Complement deficiency (HP:0004431)3.13315744
50Gastrointestinal inflammation (HP:0004386)3.13070255
51Muscle fiber splitting (HP:0003555)3.08483853
52Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.08428626
53Hyperkalemia (HP:0002153)3.04010402
54Esophageal varix (HP:0002040)2.93666816
55Pulmonary infiltrates (HP:0002113)2.90274001
56Flat acetabular roof (HP:0003180)2.90202612
57Glomerulonephritis (HP:0000099)2.88145933
58Keratoconjunctivitis (HP:0001096)2.86609365
59Thrombocytosis (HP:0001894)2.83181142
60Asymmetric septal hypertrophy (HP:0001670)2.82371386
61Distal lower limb muscle weakness (HP:0009053)2.79727451
62Cortical dysplasia (HP:0002539)2.77847130
63Abnormal rod and cone electroretinograms (HP:0008323)2.75645188
64Macular degeneration (HP:0000608)2.74886778
65Abnormality of the fingertips (HP:0001211)2.72238193
66Chronic otitis media (HP:0000389)2.70946632
67Increased IgM level (HP:0003496)2.66313507
68Gingival bleeding (HP:0000225)2.64067461
69Eosinophilia (HP:0001880)2.60851759
70Abnormality of monocarboxylic acid metabolism (HP:0010996)2.60675383
71Gastrointestinal infarctions (HP:0005244)2.59802559
72Progressive visual loss (HP:0000529)2.53967275
73Increased cerebral lipofuscin (HP:0011813)2.53567859
74Posterior subcapsular cataract (HP:0007787)2.48695400
75Hypergammaglobulinemia (HP:0010702)2.48385846
76Vascular calcification (HP:0004934)2.46831104
77Dysmetric saccades (HP:0000641)2.45379146
78Abnormality of the common coagulation pathway (HP:0010990)2.44882548
79Chorioretinal atrophy (HP:0000533)2.39040429
80Mucopolysacchariduria (HP:0008155)2.38203667
81Urinary glycosaminoglycan excretion (HP:0003541)2.38203667
82Central scotoma (HP:0000603)2.36479562
83Abnormality of mucopolysaccharide metabolism (HP:0011020)2.36297673
84Abnormality of polysaccharide metabolism (HP:0011012)2.36297673
85Abnormality of glycosaminoglycan metabolism (HP:0004371)2.36297673
86Vasculitis (HP:0002633)2.36229852
87Panhypogammaglobulinemia (HP:0003139)2.35715346
88Abnormality of the gastric mucosa (HP:0004295)2.33556905
89Male infertility (HP:0003251)2.33497667
90Abnormality of complement system (HP:0005339)2.31113646
91Chest pain (HP:0100749)2.27939263
92Increased neuronal autofluorescent lipopigment (HP:0002074)2.26728825
93Agammaglobulinemia (HP:0004432)2.26497448
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.25726935
95Abolished electroretinogram (ERG) (HP:0000550)2.23730040
96Hyperactive renin-angiotensin system (HP:0000841)2.22251495
97Abnormality of the calf musculature (HP:0001430)2.21773951
98Hypobetalipoproteinemia (HP:0003563)2.21610267
99Malnutrition (HP:0004395)2.19299874
100Tetraparesis (HP:0002273)2.19025593
101Meningitis (HP:0001287)2.17420470
102Autoimmune hemolytic anemia (HP:0001890)2.17144502
103Popliteal pterygium (HP:0009756)2.17059864
104Keratoconjunctivitis sicca (HP:0001097)2.16906040
105Hyporeflexia of lower limbs (HP:0002600)2.16749453
106Difficulty running (HP:0009046)2.16437909
107Recurrent sinusitis (HP:0011108)2.15720265
108Albinism (HP:0001022)2.14746291
109Granulocytopenia (HP:0001913)2.13865830
110Portal hypertension (HP:0001409)2.12784518
111Obstructive lung disease (HP:0006536)2.12667843
112Chronic obstructive pulmonary disease (HP:0006510)2.12667843
113Urticaria (HP:0001025)2.11674089
114Type 1 muscle fiber predominance (HP:0003803)2.10967227
115EMG: myopathic abnormalities (HP:0003458)2.10296290
116Facial diplegia (HP:0001349)2.10041441
117Cellulitis (HP:0100658)2.09832310
118Viral hepatitis (HP:0006562)2.07665947
119Leukocytosis (HP:0001974)2.07486566
120Hemoptysis (HP:0002105)2.07210554
121Right ventricular cardiomyopathy (HP:0011663)2.07000668
122Hypolipoproteinemia (HP:0010981)2.05559317
123Cardiovascular calcification (HP:0011915)2.03657254
124Cone-rod dystrophy (HP:0000548)2.02891727
125Polygenic inheritance (HP:0010982)2.02440807
126Bundle branch block (HP:0011710)2.01845832
127Infertility (HP:0000789)2.00937092
128Abnormality of the hepatic vasculature (HP:0006707)2.00217274
129Elevated erythrocyte sedimentation rate (HP:0003565)1.99833544
130Subcapsular cataract (HP:0000523)1.99045864
131Recurrent otitis media (HP:0000403)1.98957469
132Porencephaly (HP:0002132)1.97486307
133Nephritis (HP:0000123)1.96027811
134Thyroiditis (HP:0100646)1.95996659
135Hypoalphalipoproteinemia (HP:0003233)1.95296984
136Xanthomatosis (HP:0000991)1.94557114
137Dysostosis multiplex (HP:0000943)1.94335770
138Systemic lupus erythematosus (HP:0002725)1.93374855
139Muscle hypertrophy of the lower extremities (HP:0008968)1.92687524
140Abnormality of the nasal mucosa (HP:0000433)1.92606025
141Encephalitis (HP:0002383)1.92569475
142Amaurosis fugax (HP:0100576)1.92394818
143Thrombophlebitis (HP:0004418)1.91928998
144Lip pit (HP:0100267)1.91612296
145Mitral stenosis (HP:0001718)1.91524685
146Skin nodule (HP:0200036)1.90938017
147Abnormality of eosinophils (HP:0001879)1.90229059
148Papillary thyroid carcinoma (HP:0002895)1.89320045
149Nasal polyposis (HP:0100582)1.87417631
150Bronchitis (HP:0012387)1.87257458
151Increased connective tissue (HP:0009025)1.86115639
152Abnormality of glycolipid metabolism (HP:0010969)1.85068437
153Abnormality of liposaccharide metabolism (HP:0010968)1.85068437
154Abnormality of glycosphingolipid metabolism (HP:0004343)1.85068437
155Calf muscle hypertrophy (HP:0008981)1.84093953
156Frequent falls (HP:0002359)1.84074760
157Hypercholesterolemia (HP:0003124)1.83642647
158Abnormality of macular pigmentation (HP:0008002)1.81861270
159Purpura (HP:0000979)1.81230152
160Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81145066
161Spontaneous hematomas (HP:0007420)1.80881070
162Villous atrophy (HP:0011473)1.80725156
163Abnormality of small intestinal villus morphology (HP:0011472)1.80725156
164Amyloidosis (HP:0011034)1.80232719
165Abnormality of the periventricular white matter (HP:0002518)1.79155422
166Cerebral ischemia (HP:0002637)1.78864375
167Premature loss of primary teeth (HP:0006323)1.78047884
168Cerebral aneurysm (HP:0004944)1.75574395
169Photophobia (HP:0000613)1.75497145
170Menorrhagia (HP:0000132)1.75033161
171Abnormality of T cell physiology (HP:0011840)1.74125614
172Sudden death (HP:0001699)1.72827771
173Ulnar deviation of the wrist (HP:0003049)1.72744144
174Acute myeloid leukemia (HP:0004808)1.72481048
175Decreased circulating renin level (HP:0003351)1.72266520
176Epistaxis (HP:0000421)1.71695053
177Diaphragmatic weakness (HP:0009113)1.71399733
178Decreased central vision (HP:0007663)1.71339036
179Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.71035422
180Pendular nystagmus (HP:0012043)1.70960145
181Abnormality of the nasal septum (HP:0000419)1.70631926
182Abnormality of the left ventricular outflow tract (HP:0011103)1.69874147
183Subaortic stenosis (HP:0001682)1.69874147
184Ventricular tachycardia (HP:0004756)1.67652889
185Malignant hyperthermia (HP:0002047)1.67556768
186Centrally nucleated skeletal muscle fibers (HP:0003687)1.67191356
187Aplasia of the musculature (HP:0100854)1.65494831
188Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.63543639
189Loss of speech (HP:0002371)1.63491256
190Abnormality of the intrinsic pathway (HP:0010989)1.61867845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.56251594
2MAP3K134.24889587
3MAPK153.53856915
4IRAK43.45907781
5TAOK33.27527475
6TYK23.24256876
7OBSCN3.21485504
8EPHA23.18078031
9IKBKB2.64909138
10JAK32.62788282
11MST1R2.57774065
12RIPK42.41570224
13CHUK2.41421118
14IKBKE2.39842057
15TBK12.39105412
16EPHB12.32957888
17TTN2.31312687
18JAK12.23853814
19BMPR22.02837030
20MAP3K31.95173000
21ICK1.88671776
22EPHA31.80822642
23MAP2K31.71961105
24TRPM71.68595037
25NEK91.66327259
26FLT31.64270499
27PRKAA21.63427731
28FGFR41.57331815
29AKT31.55935006
30PIK3CG1.54163744
31MAP3K91.51405308
32MAPKAPK31.46395036
33EEF2K1.45032120
34ERN11.43419621
35PTK61.43384288
36FER1.43294050
37ACVR1B1.40602405
38JAK21.40557711
39KSR21.36107613
40FGFR31.33996525
41RIPK11.32190997
42MARK21.29821047
43INSRR1.28411569
44RET1.20507691
45FES1.19382582
46SIK21.19206027
47PHKG11.18992803
48PHKG21.18992803
49MOS1.12477566
50MET1.06800508
51CSK1.06664311
52CDK121.05824950
53LATS10.99212750
54KIT0.98436367
55PDK20.95785005
56ZAP700.94653405
57TNK20.92999520
58TAOK10.92558276
59CAMK1D0.92392985
60PKN10.90728229
61MST40.90061609
62CAMK1G0.89990252
63MAP2K60.88074268
64GRK10.85316698
65HIPK20.85238970
66MAP3K10.84399872
67CDK90.84195943
68MAPK120.82954611
69MTOR0.82414759
70IRAK10.81662930
71TIE10.79900787
72NLK0.79229127
73DDR20.77559500
74BTK0.76815043
75FRK0.76078777
76CSF1R0.75968058
77STK240.75871313
78SYK0.75771747
79MAP3K20.75763959
80SIK10.75316180
81BLK0.74471389
82SGK30.74214742
83IRAK30.73132350
84LMTK20.73003424
85HCK0.72325525
86EPHA40.71065161
87MELK0.68992229
88SGK10.67822448
89CAMKK10.67054201
90STK110.65421155
91MUSK0.63586053
92STK390.61639677
93WNK40.60238478
94DYRK1B0.59140562
95STK38L0.59098439
96TRIB30.58555710
97SGK20.57797808
98PKN20.56357264
99PDGFRB0.55603224
100PRKD20.55125921
101PDGFRA0.52545078
102PRKAA10.52068743
103DAPK20.51685275
104ERBB20.51233439
105PRKCZ0.50401781
106FGR0.49501730
107TEC0.49121597
108MATK0.48464737
109AKT10.48249095
110PRKCD0.47757107
111MAP3K60.47449849
112STK380.46482840
113MAP3K70.46225556
114PIM10.46050686
115CAMKK20.45692013
116MAP4K10.42922358
117PTK20.42525229
118MAPKAPK20.41479490
119IRAK20.41389108
120PTK2B0.40365215
121ABL10.40034052
122TGFBR20.39848994
123CAMK40.39713113
124LCK0.38986958
125MAPK70.38924900
126PIK3CA0.38718339
127DMPK0.38541232
128BMX0.38156723
129MARK30.37886481
130RPS6KA40.37394052
131PRKCQ0.37260669
132SGK4940.37125967
133SGK2230.37125967
134STK40.37091200
135RPS6KA10.36895321
136MAP2K20.36292053
137LRRK20.35819743
138EGFR0.35815958
139CDC42BPA0.35424206
140WNK10.34096675
141MYLK0.33878789
142STK30.33483964
143RAF10.33004311
144PDK10.32321001
145CDK60.32091841
146MAPK110.31774694
147YES10.30153945
148DYRK30.29852710
149PDPK10.27828011
150PAK60.26528324

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.59724687
2Complement and coagulation cascades_Homo sapiens_hsa046103.10818857
3Leishmaniasis_Homo sapiens_hsa051402.53839105
4Phototransduction_Homo sapiens_hsa047442.47543090
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.47316878
6Histidine metabolism_Homo sapiens_hsa003402.39105360
7Allograft rejection_Homo sapiens_hsa053302.15251605
8Osteoclast differentiation_Homo sapiens_hsa043802.05273875
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.04885453
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.99299758
11Phenylalanine metabolism_Homo sapiens_hsa003601.94857040
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.91663510
13Toxoplasmosis_Homo sapiens_hsa051451.91018659
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87767511
15TNF signaling pathway_Homo sapiens_hsa046681.83681608
16Circadian rhythm_Homo sapiens_hsa047101.75024554
17Chemokine signaling pathway_Homo sapiens_hsa040621.73653464
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.70072402
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68724486
20PPAR signaling pathway_Homo sapiens_hsa033201.58478604
21Fatty acid degradation_Homo sapiens_hsa000711.58451194
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55813428
23Chemical carcinogenesis_Homo sapiens_hsa052041.55386840
24Influenza A_Homo sapiens_hsa051641.50512382
25Fatty acid biosynthesis_Homo sapiens_hsa000611.42548710
26Measles_Homo sapiens_hsa051621.40956643
27Prolactin signaling pathway_Homo sapiens_hsa049171.39274425
28Type I diabetes mellitus_Homo sapiens_hsa049401.38935608
29Graft-versus-host disease_Homo sapiens_hsa053321.38883150
30Antigen processing and presentation_Homo sapiens_hsa046121.37863407
31Apoptosis_Homo sapiens_hsa042101.33646109
32Sphingolipid metabolism_Homo sapiens_hsa006001.32511030
33Tuberculosis_Homo sapiens_hsa051521.32113835
34Staphylococcus aureus infection_Homo sapiens_hsa051501.31157476
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.30573029
36B cell receptor signaling pathway_Homo sapiens_hsa046621.26710656
37Starch and sucrose metabolism_Homo sapiens_hsa005001.25067107
38beta-Alanine metabolism_Homo sapiens_hsa004101.24965346
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.24696186
40Type II diabetes mellitus_Homo sapiens_hsa049301.24383435
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16873905
42Pertussis_Homo sapiens_hsa051331.14883128
43Olfactory transduction_Homo sapiens_hsa047401.12718858
44African trypanosomiasis_Homo sapiens_hsa051431.11776720
45Herpes simplex infection_Homo sapiens_hsa051681.11347321
46Autoimmune thyroid disease_Homo sapiens_hsa053201.10474127
47ABC transporters_Homo sapiens_hsa020101.10467209
48Tyrosine metabolism_Homo sapiens_hsa003501.09867788
49Fructose and mannose metabolism_Homo sapiens_hsa000511.09531872
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08791843
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05585225
52Dilated cardiomyopathy_Homo sapiens_hsa054141.05459663
53Retinol metabolism_Homo sapiens_hsa008301.03378530
54Dorso-ventral axis formation_Homo sapiens_hsa043201.02561428
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02454554
56Insulin resistance_Homo sapiens_hsa049311.01311786
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.98321636
58Chronic myeloid leukemia_Homo sapiens_hsa052200.95098654
59Lysine degradation_Homo sapiens_hsa003100.93095754
60Legionellosis_Homo sapiens_hsa051340.92601768
61Small cell lung cancer_Homo sapiens_hsa052220.90026483
62Nitrogen metabolism_Homo sapiens_hsa009100.89542363
63Acute myeloid leukemia_Homo sapiens_hsa052210.89189848
64Arginine biosynthesis_Homo sapiens_hsa002200.85725625
65Pancreatic cancer_Homo sapiens_hsa052120.85159462
66Insulin signaling pathway_Homo sapiens_hsa049100.84201535
67Bile secretion_Homo sapiens_hsa049760.83589507
68Primary immunodeficiency_Homo sapiens_hsa053400.83059482
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82646085
70Ovarian steroidogenesis_Homo sapiens_hsa049130.82338234
71Viral myocarditis_Homo sapiens_hsa054160.81667793
72Morphine addiction_Homo sapiens_hsa050320.81419442
73Hepatitis C_Homo sapiens_hsa051600.80612895
74Cholinergic synapse_Homo sapiens_hsa047250.80563362
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.80299395
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79779435
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.78657592
78Renin secretion_Homo sapiens_hsa049240.76595757
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.76486918
80Glucagon signaling pathway_Homo sapiens_hsa049220.75889222
81Caffeine metabolism_Homo sapiens_hsa002320.75726547
82Hepatitis B_Homo sapiens_hsa051610.74921569
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74387674
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.74329154
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72700774
86Shigellosis_Homo sapiens_hsa051310.71597757
87Adherens junction_Homo sapiens_hsa045200.70737747
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70467099
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68792263
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67635046
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67610807
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.66394695
93Linoleic acid metabolism_Homo sapiens_hsa005910.66217795
94Asthma_Homo sapiens_hsa053100.65765531
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65408932
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65347708
97Fatty acid metabolism_Homo sapiens_hsa012120.63139530
98Notch signaling pathway_Homo sapiens_hsa043300.62940364
99Glycerolipid metabolism_Homo sapiens_hsa005610.61790735
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60976217
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60938157
102Platelet activation_Homo sapiens_hsa046110.60790770
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.60447239
104Inositol phosphate metabolism_Homo sapiens_hsa005620.60310966
105Lysosome_Homo sapiens_hsa041420.58969080
106VEGF signaling pathway_Homo sapiens_hsa043700.58187713
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57949978
108MAPK signaling pathway_Homo sapiens_hsa040100.57628883
109Non-small cell lung cancer_Homo sapiens_hsa052230.56537513
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56014916
111AMPK signaling pathway_Homo sapiens_hsa041520.55761869
112Choline metabolism in cancer_Homo sapiens_hsa052310.55627607
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55207434
114mTOR signaling pathway_Homo sapiens_hsa041500.54843390
115Tight junction_Homo sapiens_hsa045300.54473817
116Focal adhesion_Homo sapiens_hsa045100.54302095
117Amoebiasis_Homo sapiens_hsa051460.53924894
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.53360675
119Galactose metabolism_Homo sapiens_hsa000520.52360530
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52279706
121GABAergic synapse_Homo sapiens_hsa047270.52211561
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52139203
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51796515
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51200505
125T cell receptor signaling pathway_Homo sapiens_hsa046600.50653655
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.50512398
127cAMP signaling pathway_Homo sapiens_hsa040240.50389650
128Salmonella infection_Homo sapiens_hsa051320.50074844
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49705682
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49580881
131Malaria_Homo sapiens_hsa051440.49447054
132Arachidonic acid metabolism_Homo sapiens_hsa005900.49117113
133Cocaine addiction_Homo sapiens_hsa050300.47622371
134Vitamin digestion and absorption_Homo sapiens_hsa049770.47260320
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47199317
136FoxO signaling pathway_Homo sapiens_hsa040680.47025187
137Oxytocin signaling pathway_Homo sapiens_hsa049210.45865871
138GnRH signaling pathway_Homo sapiens_hsa049120.45835567
139Mineral absorption_Homo sapiens_hsa049780.44783038
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44693145
141Pancreatic secretion_Homo sapiens_hsa049720.44593071
142Tryptophan metabolism_Homo sapiens_hsa003800.43850607
143Fat digestion and absorption_Homo sapiens_hsa049750.42953080
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42649754
145Glutamatergic synapse_Homo sapiens_hsa047240.42015613
146Circadian entrainment_Homo sapiens_hsa047130.41816211
147alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41255006
148Glutathione metabolism_Homo sapiens_hsa004800.40969558
149Other glycan degradation_Homo sapiens_hsa005110.40312755
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.40056610
151Peroxisome_Homo sapiens_hsa041460.39842635

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