TBC1D9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.13117745
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.84750156
3locomotory exploration behavior (GO:0035641)5.50033043
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.39630118
5synaptic vesicle exocytosis (GO:0016079)5.03744226
6layer formation in cerebral cortex (GO:0021819)4.95846681
7regulation of synaptic vesicle exocytosis (GO:2000300)4.78758154
8glutamate secretion (GO:0014047)4.76720659
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.76276102
10vocalization behavior (GO:0071625)4.62449468
11proline transport (GO:0015824)4.62079691
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.52887845
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.35277607
14regulation of glutamate receptor signaling pathway (GO:1900449)4.24939241
15exploration behavior (GO:0035640)4.21709852
16regulation of synaptic vesicle transport (GO:1902803)4.18484787
17neurotransmitter secretion (GO:0007269)4.16318116
18protein localization to synapse (GO:0035418)4.13011723
19regulation of synapse structural plasticity (GO:0051823)4.03906399
20sodium ion export (GO:0071436)4.01478396
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.94563562
22cellular potassium ion homeostasis (GO:0030007)3.90166354
23gamma-aminobutyric acid transport (GO:0015812)3.83227640
24neuron cell-cell adhesion (GO:0007158)3.78873125
25regulation of neuronal synaptic plasticity (GO:0048168)3.70048031
26activation of protein kinase A activity (GO:0034199)3.69498329
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.67503196
28dendritic spine morphogenesis (GO:0060997)3.62626932
29dendrite morphogenesis (GO:0048813)3.61934264
30regulation of ARF protein signal transduction (GO:0032012)3.60165858
31synaptic vesicle endocytosis (GO:0048488)3.59060015
32neuromuscular process controlling balance (GO:0050885)3.54389186
33neuronal action potential propagation (GO:0019227)3.53552912
34cell migration in hindbrain (GO:0021535)3.49067779
35glutamate receptor signaling pathway (GO:0007215)3.42545381
36positive regulation of synapse maturation (GO:0090129)3.37685053
37synaptic transmission, glutamatergic (GO:0035249)3.37321913
38cerebellar Purkinje cell differentiation (GO:0021702)3.36526979
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.32282909
40long-term memory (GO:0007616)3.32016380
41neurotransmitter transport (GO:0006836)3.30046477
42clathrin coat assembly (GO:0048268)3.25367391
43response to auditory stimulus (GO:0010996)3.24979394
44protein localization to endosome (GO:0036010)3.24153983
45vesicle transport along microtubule (GO:0047496)3.19071940
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.18536805
47neuron recognition (GO:0008038)3.18152812
48neuromuscular process controlling posture (GO:0050884)3.12458132
49glycine transport (GO:0015816)3.09676361
50regulation of clathrin-mediated endocytosis (GO:2000369)3.08950134
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08846496
52regulation of neurotransmitter secretion (GO:0046928)3.08268511
53axonal fasciculation (GO:0007413)3.08021375
54cell communication by electrical coupling (GO:0010644)3.07104636
55negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.05911675
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.05613696
57neurotransmitter-gated ion channel clustering (GO:0072578)3.04443432
58cytoskeletal anchoring at plasma membrane (GO:0007016)3.04123517
59neuron-neuron synaptic transmission (GO:0007270)3.02431930
60regulation of neurotransmitter levels (GO:0001505)3.01484628
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00879484
62positive regulation of membrane potential (GO:0045838)3.00695591
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00587796
64alanine transport (GO:0032328)2.98760409
65positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98690206
66axon cargo transport (GO:0008088)2.98583070
67regulation of postsynaptic membrane potential (GO:0060078)2.96597083
68innervation (GO:0060384)2.94479481
69organelle transport along microtubule (GO:0072384)2.94300661
70dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.94073331
71ear development (GO:0043583)2.92571333
72regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.90776549
73regulation of synaptic plasticity (GO:0048167)2.90570204
74vagina development (GO:0060068)2.90023994
75cerebellar granule cell differentiation (GO:0021707)2.86187870
76membrane depolarization during action potential (GO:0086010)2.85834927
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.85613899
78regulation of vesicle fusion (GO:0031338)2.83555039
79transmission of nerve impulse (GO:0019226)2.83216395
80positive regulation of nitric-oxide synthase activity (GO:0051000)2.82856098
81cerebellar Purkinje cell layer development (GO:0021680)2.82418353
82positive regulation of Cdc42 GTPase activity (GO:0043089)2.82241371
83auditory behavior (GO:0031223)2.80496499
84neuromuscular process (GO:0050905)2.79054028
85insulin-like growth factor receptor signaling pathway (GO:0048009)2.78280027
86prepulse inhibition (GO:0060134)2.78139590
87nerve growth factor signaling pathway (GO:0038180)2.77972294
88semaphorin-plexin signaling pathway (GO:0071526)2.76698651
89regulation of dendritic spine morphogenesis (GO:0061001)2.75357356
90regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74789411
91regulation of neurotransmitter transport (GO:0051588)2.74646984
92potassium ion import (GO:0010107)2.74517193
93gamma-aminobutyric acid signaling pathway (GO:0007214)2.70452790
94regulation of synaptic transmission, glutamatergic (GO:0051966)2.69950971
95mating behavior (GO:0007617)2.69434382
96synapse assembly (GO:0007416)2.69082746
97membrane depolarization (GO:0051899)2.69049425
98positive regulation of cellular amide metabolic process (GO:0034250)2.68904751
99negative regulation of fatty acid transport (GO:2000192)2.68385038
100positive regulation of synaptic transmission, GABAergic (GO:0032230)2.67858301
101establishment of nucleus localization (GO:0040023)2.66894218
102regulation of calcium ion-dependent exocytosis (GO:0017158)2.65393355
103adult walking behavior (GO:0007628)2.64654532
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.63880778
105social behavior (GO:0035176)2.63495738
106intraspecies interaction between organisms (GO:0051703)2.63495738
107negative regulation of microtubule polymerization (GO:0031115)2.62861348
108response to pheromone (GO:0019236)2.62385009
109postsynaptic membrane organization (GO:0001941)2.61434650
110negative regulation of synaptic transmission, GABAergic (GO:0032229)2.61247591
111cellular sodium ion homeostasis (GO:0006883)2.60029126
112regulation of ARF GTPase activity (GO:0032312)2.59124357
113epithelial cell differentiation involved in prostate gland development (GO:0060742)2.56112912
114regulation of T-helper 2 cell differentiation (GO:0045628)2.55274951
115negative regulation of focal adhesion assembly (GO:0051895)2.51324269
116negative regulation of cell junction assembly (GO:1901889)2.51324269
117negative regulation of adherens junction organization (GO:1903392)2.51324269
118positive regulation of keratinocyte differentiation (GO:0045618)2.49122105
119uterus development (GO:0060065)2.47760037
120macroautophagy (GO:0016236)2.46420107
121cell adhesion mediated by integrin (GO:0033627)2.44007727
122cell-cell junction maintenance (GO:0045217)2.37444680
123COPI coating of Golgi vesicle (GO:0048205)2.37017526
124Golgi transport vesicle coating (GO:0048200)2.37017526
125branching involved in mammary gland duct morphogenesis (GO:0060444)2.27974883
126positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.27037589
127endothelial cell chemotaxis (GO:0035767)2.23988639
128interferon-gamma secretion (GO:0072643)2.23386994
129maternal placenta development (GO:0001893)2.22544934
130positive regulation of receptor recycling (GO:0001921)2.21497581
131production of molecular mediator involved in inflammatory response (GO:0002532)2.20768870
132epithelial cell-cell adhesion (GO:0090136)2.18573796
133intestinal epithelial cell development (GO:0060576)2.17681838
134positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.17117791
135barbed-end actin filament capping (GO:0051016)2.17096706
136regulation of early endosome to late endosome transport (GO:2000641)2.15740919
137negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.15556668
138regulation of cell proliferation involved in kidney development (GO:1901722)2.13767148
139glomerular basement membrane development (GO:0032836)2.13519127
140positive regulation of type 2 immune response (GO:0002830)2.10598491
141lipopolysaccharide-mediated signaling pathway (GO:0031663)2.10597008
142regulation of establishment of cell polarity (GO:2000114)2.09949302
143response to peptidoglycan (GO:0032494)2.09525101
144Rap protein signal transduction (GO:0032486)2.07260196
145endocytic recycling (GO:0032456)2.06601114
146regulation of establishment or maintenance of cell polarity (GO:0032878)2.05420158
147cellular response to interferon-alpha (GO:0035457)2.04775424
148vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.04714602
149response to laminar fluid shear stress (GO:0034616)2.04252580
150amyloid precursor protein catabolic process (GO:0042987)2.04197763
151regulation of glucose import in response to insulin stimulus (GO:2001273)2.03866555
152macrophage activation involved in immune response (GO:0002281)2.03695231
153surfactant homeostasis (GO:0043129)2.03643620
154retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.02469451
155female genitalia development (GO:0030540)2.02108143
156mannose metabolic process (GO:0006013)2.01834017
157adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)1.99697751
158positive regulation of nitric oxide biosynthetic process (GO:0045429)1.98844429
159positive regulation of monooxygenase activity (GO:0032770)1.98743350
160apical protein localization (GO:0045176)1.98682774
161adherens junction assembly (GO:0034333)1.97716982
162negative regulation of organic acid transport (GO:0032891)1.96516410
163positive regulation of neurotransmitter secretion (GO:0001956)1.95699626
164dopamine receptor signaling pathway (GO:0007212)1.95511263
165regulation of membrane protein ectodomain proteolysis (GO:0051043)1.95360279
166regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00431.94538888
167activation of MAPKKK activity (GO:0000185)1.94212026
168cell junction maintenance (GO:0034331)1.93592820
169wound healing, spreading of epidermal cells (GO:0035313)1.93018628
170regulation of NFAT protein import into nucleus (GO:0051532)1.92281199
171positive regulation of cholesterol efflux (GO:0010875)1.92203816
172embryonic camera-type eye morphogenesis (GO:0048596)1.91961605
173striated muscle atrophy (GO:0014891)1.90651002
174response to manganese ion (GO:0010042)1.90325494
175positive regulation of smooth muscle cell migration (GO:0014911)1.90255595
176regulation of phosphatidylinositol 3-kinase activity (GO:0043551)1.90181569
177response to nerve growth factor (GO:1990089)1.90122123
178cellular response to nerve growth factor stimulus (GO:1990090)1.90122123
179apoptotic cell clearance (GO:0043277)1.88832135
180response to water (GO:0009415)1.88393626
181retina vasculature morphogenesis in camera-type eye (GO:0061299)1.88250712
182regulation of cholesterol storage (GO:0010885)1.88118666
183response to fluid shear stress (GO:0034405)1.88065479
184stress fiber assembly (GO:0043149)1.87800106
185positive regulation of steroid biosynthetic process (GO:0010893)1.87219228
186skeletal muscle adaptation (GO:0043501)1.87189612
187endocrine hormone secretion (GO:0060986)1.86835620
188regulation of lipid kinase activity (GO:0043550)1.86137844
189negative regulation of protein localization to plasma membrane (GO:1903077)1.85998587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.79668930
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.28720267
3ESR1_20079471_ChIP-ChIP_T-47D_Human3.09775202
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.66801949
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66471871
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61218782
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.60329960
8REST_21632747_ChIP-Seq_MESCs_Mouse2.56811976
9DROSHA_22980978_ChIP-Seq_HELA_Human2.54514981
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.41730024
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.41730024
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.37905602
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.35973533
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33785528
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.33733064
16GBX2_23144817_ChIP-Seq_PC3_Human2.32561938
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31137010
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27966981
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17702511
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13364934
21* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12034659
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.06653637
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.05628296
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03993260
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.03105324
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.00787264
27TRIM28_21343339_ChIP-Seq_HEK293_Human1.96789794
28EZH2_27304074_Chip-Seq_ESCs_Mouse1.93207226
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.86793724
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86265547
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.76580488
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74314918
33KDM2B_26808549_Chip-Seq_K562_Human1.69433867
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.67041048
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.66662918
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.66139908
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.62516455
38RACK7_27058665_Chip-Seq_MCF-7_Human1.62422064
39AR_21572438_ChIP-Seq_LNCaP_Human1.62065740
40* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56989448
41CLOCK_20551151_ChIP-Seq_293T_Human1.53680565
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.50857383
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42363740
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42022059
45* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40824761
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40701705
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39269299
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36466090
49* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35809119
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34772951
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33585128
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33200921
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33066274
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32141152
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.31737570
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31573865
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30937103
58SMAD4_21799915_ChIP-Seq_A2780_Human1.30802535
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29924653
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29790885
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29226877
62ZNF274_21170338_ChIP-Seq_K562_Hela1.28666148
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27954782
64* TCF7_22412390_ChIP-Seq_EML_Mouse1.27877901
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27480488
66* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27068724
67* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24421546
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.24328842
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.23831079
70AHR_22903824_ChIP-Seq_MCF-7_Human1.23510166
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23159834
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.21957360
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21617791
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21493498
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20830086
76IRF8_27001747_Chip-Seq_BMDM_Mouse1.20323552
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.20042979
78* AR_19668381_ChIP-Seq_PC3_Human1.18248507
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17753190
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17674877
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17420375
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17360996
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.17027079
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16571573
85ARNT_22903824_ChIP-Seq_MCF-7_Human1.13850303
86* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11062467
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10701405
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06774075
89KDM2B_26808549_Chip-Seq_DND41_Human1.06690161
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05132147
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05070317
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04709208
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04393417
94AR_25329375_ChIP-Seq_VCAP_Human1.03456813
95STAT3_23295773_ChIP-Seq_U87_Human1.03426666
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03181774
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02566116
98SMAD3_21741376_ChIP-Seq_ESCs_Human1.02564551
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.01449635
100P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01104275
101CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00365168
102RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00059172
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99177061
104IGF1R_20145208_ChIP-Seq_DFB_Human0.98845377
105YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98689961
106KDM2B_26808549_Chip-Seq_JURKAT_Human0.97669860
107TBX20_22080862_ChIP-Seq_HEART_Mouse0.97459181
108TBX20_22328084_ChIP-Seq_HEART_Mouse0.97459181
109FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97156557
110MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96548477
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.96476099
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96444055
113* FOXA2_19822575_ChIP-Seq_HepG2_Human0.96080993
114GATA3_24758297_ChIP-Seq_MCF-7_Human0.95867792
115* SOX2_20726797_ChIP-Seq_SW620_Human0.95693403
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94297906
117PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93975163
118RXR_22108803_ChIP-Seq_LS180_Human0.93898500
119NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93417350
120* TET1_21490601_ChIP-Seq_MESCs_Mouse0.92714300
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.91679596
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90113489
123TP53_16413492_ChIP-PET_HCT116_Human0.90011966
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89753640
125VDR_24787735_ChIP-Seq_THP-1_Human0.89634989
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89512386
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89053105
128SMAD3_21741376_ChIP-Seq_EPCs_Human0.88482564
129* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87961095
130ZNF263_19887448_ChIP-Seq_K562_Human0.87850021
131CDX2_20551321_ChIP-Seq_CACO-2_Human0.87269810
132EP300_21415370_ChIP-Seq_HL-1_Mouse0.87229339
133SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87205289
134SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87205289
135ESR2_21235772_ChIP-Seq_MCF-7_Human0.87149908
136* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86959452
137* SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86842623
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86607227
139BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86232408
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85452588
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85139376
142TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84070676
143STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83298792
144* TCF4_23295773_ChIP-Seq_U87_Human0.82589749
145LXR_22292898_ChIP-Seq_THP-1_Human0.81742148
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81683334
147EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81381220
148P300_19829295_ChIP-Seq_ESCs_Human0.80706169
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.80265510
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79169773

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.54272651
2MP0003635_abnormal_synaptic_transmissio3.94329433
3MP0004270_analgesia3.79526103
4MP0003705_abnormal_hypodermis_morpholog3.49835471
5MP0003880_abnormal_central_pattern3.30830641
6MP0009046_muscle_twitch3.28129602
7MP0002063_abnormal_learning/memory/cond3.07762852
8MP0002064_seizures2.95753458
9MP0000569_abnormal_digit_pigmentation2.95129910
10MP0009745_abnormal_behavioral_response2.92334160
11MP0004858_abnormal_nervous_system2.87752725
12MP0001968_abnormal_touch/_nociception2.87167380
13MP0005423_abnormal_somatic_nervous2.87160967
14MP0003191_abnormal_cellular_cholesterol2.76577922
15MP0002734_abnormal_mechanical_nocicepti2.75310347
16MP0002572_abnormal_emotion/affect_behav2.50033119
17MP0002735_abnormal_chemical_nociception2.44254536
18MP0002733_abnormal_thermal_nociception2.36186784
19MP0001501_abnormal_sleep_pattern2.25956839
20MP0002736_abnormal_nociception_after2.17076905
21MP0001486_abnormal_startle_reflex2.15315948
22MP0009840_abnormal_foam_cell2.15286842
23MP0002272_abnormal_nervous_system2.12617850
24MP0001970_abnormal_pain_threshold2.10294523
25MP0003172_abnormal_lysosome_physiology2.09830794
26MP0001440_abnormal_grooming_behavior2.08872690
27MP0003091_abnormal_cell_migration2.06066698
28MP0004811_abnormal_neuron_physiology2.03744180
29MP0002909_abnormal_adrenal_gland2.02628793
30MP0005409_darkened_coat_color2.01521451
31MP0003329_amyloid_beta_deposits2.01092426
32MP0002184_abnormal_innervation2.00013598
33MP0000778_abnormal_nervous_system1.97346609
34MP0009780_abnormal_chondrocyte_physiolo1.95158603
35MP0008438_abnormal_cutaneous_collagen1.93692080
36MP0008569_lethality_at_weaning1.91299570
37MP0002067_abnormal_sensory_capabilities1.90541606
38MP0004510_myositis1.89678413
39MP0005257_abnormal_intraocular_pressure1.89590961
40MP0005248_abnormal_Harderian_gland1.87367595
41MP0003303_peritoneal_inflammation1.87070083
42MP0003300_gastrointestinal_ulcer1.82279610
43MP0002877_abnormal_melanocyte_morpholog1.80690923
44MP0002557_abnormal_social/conspecific_i1.70841683
45MP0000955_abnormal_spinal_cord1.69640310
46MP0003566_abnormal_cell_adhesion1.69106119
47MP0003879_abnormal_hair_cell1.63277530
48MP0002896_abnormal_bone_mineralization1.60973732
49MP0001849_ear_inflammation1.56436711
50MP0005386_behavior/neurological_phenoty1.55342185
51MP0004924_abnormal_behavior1.55342185
52MP0004885_abnormal_endolymph1.55036738
53MP0003453_abnormal_keratinocyte_physiol1.53821145
54MP0010678_abnormal_skin_adnexa1.50570470
55MP0002796_impaired_skin_barrier1.49419275
56MP0001958_emphysema1.48281448
57MP0004264_abnormal_extraembryonic_tissu1.47776647
58MP0003633_abnormal_nervous_system1.46300437
59MP0000604_amyloidosis1.45419428
60MP0002882_abnormal_neuron_morphology1.45131454
61MP0008961_abnormal_basal_metabolism1.43878982
62MP0000767_abnormal_smooth_muscle1.42661791
63MP0002998_abnormal_bone_remodeling1.37761810
64MP0002066_abnormal_motor_capabilities/c1.35672521
65MP0002332_abnormal_exercise_endurance1.35447101
66MP0005451_abnormal_body_composition1.35113033
67MP0000383_abnormal_hair_follicle1.34777652
68MP0006276_abnormal_autonomic_nervous1.34335193
69MP0003123_paternal_imprinting1.32076287
70MP0008260_abnormal_autophagy1.30689027
71MP0006082_CNS_inflammation1.29748777
72MP0003279_aneurysm1.29331122
73MP0003690_abnormal_glial_cell1.29177136
74MP0003075_altered_response_to1.27634508
75MP0004782_abnormal_surfactant_physiolog1.24357939
76MP0003634_abnormal_glial_cell1.22341346
77MP0001502_abnormal_circadian_rhythm1.21398775
78MP0003631_nervous_system_phenotype1.18495221
79MP0003724_increased_susceptibility_to1.17194765
80MP0003183_abnormal_peptide_metabolism1.14391281
81MP0002822_catalepsy1.12882396
82MP0003787_abnormal_imprinting1.12426557
83MP0002152_abnormal_brain_morphology1.11954898
84MP0005645_abnormal_hypothalamus_physiol1.11115038
85MP0009384_cardiac_valve_regurgitation1.09420678
86MP0005275_abnormal_skin_tensile1.08466307
87MP0001533_abnormal_skeleton_physiology1.08413451
88MP0002229_neurodegeneration1.06232502
89MP0003828_pulmonary_edema1.05242024
90MP0005058_abnormal_lysosome_morphology1.04703968
91MP0001542_abnormal_bone_strength1.03841364
92MP0001984_abnormal_olfaction1.02502783
93MP0000462_abnormal_digestive_system1.01341768
94MP0004883_abnormal_blood_vessel0.99877129
95MP0000343_altered_response_to0.98866905
96MP0002090_abnormal_vision0.98729123
97MP0003283_abnormal_digestive_organ0.98384961
98MP0001348_abnormal_lacrimal_gland0.97766690
99MP0004947_skin_inflammation0.97511974
100MP0005666_abnormal_adipose_tissue0.96052418
101MP0004381_abnormal_hair_follicle0.95583072
102MP0003632_abnormal_nervous_system0.93634736
103MP0010386_abnormal_urinary_bladder0.92827047
104MP0010234_abnormal_vibrissa_follicle0.90944830
105MP0004272_abnormal_basement_membrane0.90165469
106MP0004142_abnormal_muscle_tone0.89807625
107MP0004742_abnormal_vestibular_system0.89778388
108MP0005167_abnormal_blood-brain_barrier0.88090999
109MP0009115_abnormal_fat_cell0.87506111
110MP0008004_abnormal_stomach_pH0.87389597
111MP0001727_abnormal_embryo_implantation0.87305996
112MP0002098_abnormal_vibrissa_morphology0.86818640
113MP0005535_abnormal_body_temperature0.86802871
114MP0005375_adipose_tissue_phenotype0.86106249
115MP0005164_abnormal_response_to0.83591722
116MP0003436_decreased_susceptibility_to0.83231717
117MP0000627_abnormal_mammary_gland0.83046174
118MP0008874_decreased_physiological_sensi0.82766211
119MP0002069_abnormal_eating/drinking_beha0.81583309
120MP0001299_abnormal_eye_distance/0.78929817
121MP0003045_fibrosis0.77723908
122MP0004145_abnormal_muscle_electrophysio0.75281469
123MP0002419_abnormal_innate_immunity0.73312369
124MP0000858_altered_metastatic_potential0.73269522
125MP0005623_abnormal_meninges_morphology0.72084969
126MP0000371_diluted_coat_color0.71633257
127MP0000920_abnormal_myelination0.71523776
128MP0005166_decreased_susceptibility_to0.70922726
129MP0008872_abnormal_physiological_respon0.70265241
130MP0005646_abnormal_pituitary_gland0.69753371
131MP0002971_abnormal_brown_adipose0.69750314
132MP0005499_abnormal_olfactory_system0.69108129
133MP0005394_taste/olfaction_phenotype0.69108129
134MP0004185_abnormal_adipocyte_glucose0.68976108
135MP0005595_abnormal_vascular_smooth0.68206363
136MP0001963_abnormal_hearing_physiology0.66251066
137MP0002653_abnormal_ependyma_morphology0.65999138
138MP0004130_abnormal_muscle_cell0.65764785
139MP0002752_abnormal_somatic_nervous0.65386889
140MP0003868_abnormal_feces_composition0.64526982
141MP0001177_atelectasis0.64308760
142MP0002168_other_aberrant_phenotype0.64124116
143MP0003942_abnormal_urinary_system0.64062300
144MP0003122_maternal_imprinting0.63557066
145MP0005076_abnormal_cell_differentiation0.63510144
146MP0005187_abnormal_penis_morphology0.63052361
147MP0009785_altered_susceptibility_to0.63038236
148MP0002089_abnormal_postnatal_growth/wei0.61468897
149MP0002133_abnormal_respiratory_system0.60475737
150MP0005388_respiratory_system_phenotype0.60475737
151MP0003861_abnormal_nervous_system0.58104690
152MP0005551_abnormal_eye_electrophysiolog0.57321410
153MP0005310_abnormal_salivary_gland0.56882446
154MP0000013_abnormal_adipose_tissue0.56302546
155MP0004085_abnormal_heartbeat0.55711616
156MP0004233_abnormal_muscle_weight0.55314606
157MP0001905_abnormal_dopamine_level0.52183362
158MP0004484_altered_response_of0.51285830
159MP0010769_abnormal_survival0.50850069
160MP0002082_postnatal_lethality0.48151421
161MP0010770_preweaning_lethality0.48151421
162MP0010768_mortality/aging0.46000432

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.51974226
2Visual hallucinations (HP:0002367)5.16871301
3Focal motor seizures (HP:0011153)4.96645722
4Mutism (HP:0002300)4.77270283
5Focal seizures (HP:0007359)4.64282414
6Supranuclear gaze palsy (HP:0000605)4.48254690
7Action tremor (HP:0002345)4.28478041
8Progressive cerebellar ataxia (HP:0002073)4.06102055
9J-shaped sella turcica (HP:0002680)3.94543619
10Absent frontal sinuses (HP:0002688)3.63405804
11Papilledema (HP:0001085)3.45150784
12Epileptic encephalopathy (HP:0200134)3.44118741
13Febrile seizures (HP:0002373)3.41220541
14Atonic seizures (HP:0010819)3.39448375
15Absence seizures (HP:0002121)3.27182446
16Ankle clonus (HP:0011448)3.27164789
17Asymmetry of the thorax (HP:0001555)3.09190409
18Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.08526158
19Mucopolysacchariduria (HP:0008155)3.05455705
20Urinary glycosaminoglycan excretion (HP:0003541)3.05455705
21Thin bony cortex (HP:0002753)3.04888578
22Postural instability (HP:0002172)2.98487696
23Generalized tonic-clonic seizures (HP:0002069)2.97493431
24Dialeptic seizures (HP:0011146)2.97477751
25Cerebral aneurysm (HP:0004944)2.95393065
26Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.94477440
27Genetic anticipation (HP:0003743)2.93537268
28Urinary bladder sphincter dysfunction (HP:0002839)2.89008937
29Depression (HP:0000716)2.88073976
30Abnormality of polysaccharide metabolism (HP:0011012)2.86651100
31Abnormality of glycosaminoglycan metabolism (HP:0004371)2.86651100
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.86651100
33Amyotrophic lateral sclerosis (HP:0007354)2.82880286
34Truncal ataxia (HP:0002078)2.80756568
35Diplopia (HP:0000651)2.79881921
36Abnormality of binocular vision (HP:0011514)2.79881921
37Abnormality of the lower motor neuron (HP:0002366)2.79342708
38Deformed sella turcica (HP:0002681)2.77977086
39Inappropriate behavior (HP:0000719)2.76540518
40Apathy (HP:0000741)2.75279924
41Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.72052281
42Neuronal loss in central nervous system (HP:0002529)2.71298615
43Testicular neoplasm (HP:0010788)2.70158834
44Neurofibrillary tangles (HP:0002185)2.66960071
45Poor eye contact (HP:0000817)2.64988706
46Hemiparesis (HP:0001269)2.64371214
47Arterial tortuosity (HP:0005116)2.64028391
48Cerebral inclusion bodies (HP:0100314)2.62506673
49Hemiplegia (HP:0002301)2.61831024
50Abnormal eating behavior (HP:0100738)2.59189644
51Broad-based gait (HP:0002136)2.58148577
52Gaze-evoked nystagmus (HP:0000640)2.57287283
53Impaired social interactions (HP:0000735)2.56717422
54Abnormal social behavior (HP:0012433)2.56717422
55Drooling (HP:0002307)2.55315745
56Excessive salivation (HP:0003781)2.55315745
57Increased cerebral lipofuscin (HP:0011813)2.55242672
58Intention tremor (HP:0002080)2.53513638
59Agitation (HP:0000713)2.52897250
60Esophageal varix (HP:0002040)2.50187632
61Impaired smooth pursuit (HP:0007772)2.49733945
62Dysdiadochokinesis (HP:0002075)2.48583259
63Diminished motivation (HP:0000745)2.47535512
64Long toe (HP:0010511)2.46827575
65Dysmetria (HP:0001310)2.46266982
66Abnormality of the corticospinal tract (HP:0002492)2.46251733
67Cervical subluxation (HP:0003308)2.45004179
68Impaired vibration sensation in the lower limbs (HP:0002166)2.43707250
69Loss of speech (HP:0002371)2.43357780
70Hyperparathyroidism (HP:0000843)2.42037606
71Urinary urgency (HP:0000012)2.41320147
72Vascular tortuosity (HP:0004948)2.40545996
73Progressive inability to walk (HP:0002505)2.39798809
74Disinhibition (HP:0000734)2.39265566
75Ventricular fibrillation (HP:0001663)2.39120929
76Protrusio acetabuli (HP:0003179)2.38207089
77Nuclear cataract (HP:0100018)2.38179855
78Germ cell neoplasia (HP:0100728)2.38044151
79Termporal pattern (HP:0011008)2.35887936
80Insidious onset (HP:0003587)2.35887936
81Abnormality of the frontal sinuses (HP:0002687)2.34919537
82Abnormality of liposaccharide metabolism (HP:0010968)2.33347775
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.33347775
84Abnormality of glycolipid metabolism (HP:0010969)2.33347775
85Abnormality of ocular smooth pursuit (HP:0000617)2.31252202
86Broad face (HP:0000283)2.25592868
87Akinesia (HP:0002304)2.23658252
88Glomerulonephritis (HP:0000099)2.23189893
89Obstructive sleep apnea (HP:0002870)2.22083610
90Stereotypic behavior (HP:0000733)2.20730493
91Spastic gait (HP:0002064)2.20694354
92Flat acetabular roof (HP:0003180)2.20126030
93Syringomyelia (HP:0003396)2.17601387
94Spinal cord lesions (HP:0100561)2.17601387
95Amblyopia (HP:0000646)2.15442579
96Mitral stenosis (HP:0001718)2.15274772
97Pointed chin (HP:0000307)2.15036429
98Limb dystonia (HP:0002451)2.14807941
99Insomnia (HP:0100785)2.12806608
100Megalencephaly (HP:0001355)2.12486425
101Bradykinesia (HP:0002067)2.12469575
102Failure to thrive in infancy (HP:0001531)2.12074020
103Macroorchidism (HP:0000053)2.10861822
104Interstitial pulmonary disease (HP:0006530)2.10857289
105Polyphagia (HP:0002591)2.09535152
106Micronodular cirrhosis (HP:0001413)2.08638634
107Torticollis (HP:0000473)2.05883315
108Axonal loss (HP:0003447)2.05576847
109Rapidly progressive (HP:0003678)2.04839741
110Aqueductal stenosis (HP:0002410)2.04729203
111Annular pancreas (HP:0001734)2.02115878
112Abnormality of the sella turcica (HP:0002679)2.01462625
113Vertebral compression fractures (HP:0002953)2.01365037
114Anxiety (HP:0000739)2.00353971
115Lower limb asymmetry (HP:0100559)2.00052105
116Buphthalmos (HP:0000557)1.99240628
117Short nail (HP:0001799)1.99201521
118Lower limb muscle weakness (HP:0007340)1.98821300
119Dysmetric saccades (HP:0000641)1.98619654
120Postural tremor (HP:0002174)1.97346496
121Status epilepticus (HP:0002133)1.93654439
122Bundle branch block (HP:0011710)1.93187421
123Hyperacusis (HP:0010780)1.91734803
124Premature rupture of membranes (HP:0001788)1.88923181
125Pheochromocytoma (HP:0002666)1.88272031
126Abnormality of macrophages (HP:0004311)1.87808120
127Hand muscle atrophy (HP:0009130)1.87520815
128Papillary thyroid carcinoma (HP:0002895)1.87408625
129Fetal akinesia sequence (HP:0001989)1.87242408
130Hypercortisolism (HP:0001578)1.84267489
131EEG with generalized epileptiform discharges (HP:0011198)1.83882760
132Vacuolated lymphocytes (HP:0001922)1.83673769
133Scanning speech (HP:0002168)1.83169065
134Abnormality of the periventricular white matter (HP:0002518)1.81477671
135Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81074359
136Hypsarrhythmia (HP:0002521)1.81028451
137Dementia (HP:0000726)1.80994372
138Epileptiform EEG discharges (HP:0011182)1.80955330
139Abnormality of calcium-phosphate metabolism (HP:0100530)1.78773024
140Morphological abnormality of the pyramidal tract (HP:0002062)1.78492202
141Sparse lateral eyebrow (HP:0005338)1.77902128
142Dysostosis multiplex (HP:0000943)1.77385837
143Asymmetric septal hypertrophy (HP:0001670)1.76672954
144Bone pain (HP:0002653)1.76651198
145Focal dystonia (HP:0004373)1.76631835
146Congenital glaucoma (HP:0001087)1.75855511
147Rigidity (HP:0002063)1.75837247
148Absent speech (HP:0001344)1.75493290
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.74397604
150Osteolytic defects of the hand bones (HP:0009699)1.74397604
151Amyloidosis (HP:0011034)1.74063753
152Abdominal distention (HP:0003270)1.73220619
153Increased neuronal autofluorescent lipopigment (HP:0002074)1.73157910
154Aneurysm (HP:0002617)1.71204939
155Aortic dissection (HP:0002647)1.70860549
156Systemic lupus erythematosus (HP:0002725)1.70829891
157Myocardial infarction (HP:0001658)1.68697692
158Mitral regurgitation (HP:0001653)1.68295000
159Spinal cord compression (HP:0002176)1.68153753
160Spondylolisthesis (HP:0003302)1.64666239
161Mitral valve prolapse (HP:0001634)1.63855783
162Malnutrition (HP:0004395)1.59679856
163Eczematoid dermatitis (HP:0000976)1.59312646
164Distal lower limb muscle weakness (HP:0009053)1.58615197
165Distal upper limb amyotrophy (HP:0007149)1.57129409
166Upper limb amyotrophy (HP:0009129)1.57129409
167Lymphangioma (HP:0100764)1.56550352
168Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.56505389
169Deep venous thrombosis (HP:0002625)1.56088870
170Enlarged penis (HP:0000040)1.56067297
171Urinary incontinence (HP:0000020)1.55793638
172Overgrowth (HP:0001548)1.55078254
173Pathologic fracture (HP:0002756)1.54749038
174Abnormality of the distal phalanges of the toes (HP:0010182)1.53731566
175Visceral angiomatosis (HP:0100761)1.53462995

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.75984150
2MARK14.59455053
3NTRK33.50940747
4SIK12.89092876
5MINK12.71397201
6MAP3K42.68212425
7PAK62.56383755
8DAPK22.44982320
9IRAK32.41357506
10KSR22.30219678
11CAMKK12.29569863
12RIPK42.22167739
13NTRK22.17152323
14NTRK12.05568516
15MAP2K71.83890575
16EPHA41.81310909
17PIK3CA1.81235360
18SIK21.76664702
19PRKD31.74361917
20MAP2K41.65063831
21NEK61.61998374
22RIPK11.58805943
23LATS21.57207093
24GRK51.55851600
25TAOK11.54179695
26CAMKK21.51181980
27TESK11.51114731
28MAP3K21.49346060
29CDK51.46857607
30STK381.46456607
31FGFR41.46008752
32KSR11.45379973
33PHKG21.42259624
34PHKG11.42259624
35ERN11.41683936
36SCYL21.37499526
37ALK1.35948744
38CHUK1.35413559
39RET1.31255878
40SIK31.25841906
41TYRO31.19760255
42CAMK1G1.19058589
43EPHA21.16844123
44PNCK1.15800547
45DAPK11.14026125
46STK111.13019352
47IKBKE1.08146324
48MAPK131.07928004
49MAP3K141.05877389
50MAP3K121.04529392
51EEF2K1.01239208
52BMPR21.00615991
53PLK20.98938971
54MAP3K130.97537404
55FES0.96789035
56TBK10.96283471
57CSNK1G20.96102646
58TTN0.95314446
59PRKCG0.94209625
60PAK40.93032142
61BLK0.92668626
62TGFBR20.92135365
63LMTK20.91344762
64PRKCH0.90384033
65UHMK10.89554600
66MAP3K30.89251028
67ARAF0.85112528
68NME20.84950870
69TYK20.81572003
70IRAK20.79531935
71PDGFRB0.77289622
72PTK20.77185103
73CSF1R0.77117459
74FER0.76513306
75MTOR0.75053748
76PDK10.73879608
77CDK150.73551867
78WNK10.73346868
79TRIB30.73306778
80PAK30.72784780
81MAPKAPK30.71990989
82CDK140.71278905
83CDK180.71259722
84MAP2K20.71181872
85ICK0.71170548
86FGR0.70341925
87PRKCZ0.70140293
88CDK190.69987145
89RPS6KA20.69645650
90RPS6KL10.69290022
91RPS6KC10.69290022
92RPS6KB10.68741248
93CAMK2B0.68118003
94SMG10.66806035
95CSK0.65082514
96SGK30.64979112
97PDPK10.64762175
98ERBB30.64729667
99CAMK2A0.63307290
100MARK20.63052352
101DYRK1B0.62601000
102CAMK10.62577148
103SGK10.62382698
104FGFR30.61934915
105CDK11A0.61479371
106MAPK40.59172671
107PRKD20.57996943
108MOS0.57933440
109PRKD10.57300736
110FYN0.57284669
111MAP2K10.57045636
112CASK0.56786945
113MATK0.55962770
114MAP3K10.54825562
115JAK10.53270411
116CAMK1D0.53253514
117SGK4940.53018223
118SGK2230.53018223
119DDR20.52508982
120DYRK1A0.52492794
121CDC42BPA0.52406205
122PRPF4B0.52195575
123MYLK0.49995485
124RPS6KA60.49109906
125TAOK20.48767665
126ROCK20.48430071
127RPS6KA30.45872239
128MAPK100.45830121
129RAF10.44778849
130RPS6KB20.44694392
131SGK20.44587777
132MAP3K110.44474342
133CAMK40.43915023
134JAK20.42869460
135PKN10.38561269
136PDGFRA0.38153456
137MAP3K60.37713092
138PKN20.37394492
139MAPK120.36977759
140CSNK1G30.34419874
141BMX0.34207150
142PRKCE0.33854279
143TNIK0.33740490
144CSNK1A1L0.33402785
145LIMK10.32275317
146MAPK80.30883028
147PTK60.30125034
148SRC0.28786128
149DMPK0.28473728
150HIPK20.28010323

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.00360317
2Nicotine addiction_Homo sapiens_hsa050332.52337287
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.26389069
4GABAergic synapse_Homo sapiens_hsa047272.12530125
5Olfactory transduction_Homo sapiens_hsa047402.12134694
6Circadian entrainment_Homo sapiens_hsa047132.10894907
7Long-term potentiation_Homo sapiens_hsa047202.08152994
8Glutamatergic synapse_Homo sapiens_hsa047242.03724561
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99861063
10Morphine addiction_Homo sapiens_hsa050321.91210564
11Salivary secretion_Homo sapiens_hsa049701.79882438
12Dopaminergic synapse_Homo sapiens_hsa047281.72938015
13Amphetamine addiction_Homo sapiens_hsa050311.72785746
14Other glycan degradation_Homo sapiens_hsa005111.69979970
15Cholinergic synapse_Homo sapiens_hsa047251.68780209
16Gastric acid secretion_Homo sapiens_hsa049711.64889999
17Insulin secretion_Homo sapiens_hsa049111.62875887
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.59190370
19Type II diabetes mellitus_Homo sapiens_hsa049301.54815427
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51642306
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50611411
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48278716
23Long-term depression_Homo sapiens_hsa047301.46079422
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43551994
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38304947
26GnRH signaling pathway_Homo sapiens_hsa049121.37937988
27Renin secretion_Homo sapiens_hsa049241.37886765
28Oxytocin signaling pathway_Homo sapiens_hsa049211.36350413
29Estrogen signaling pathway_Homo sapiens_hsa049151.34207527
30Taste transduction_Homo sapiens_hsa047421.34126754
31Cocaine addiction_Homo sapiens_hsa050301.29226602
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28985301
33Serotonergic synapse_Homo sapiens_hsa047261.28850972
34Amoebiasis_Homo sapiens_hsa051461.25695987
35Gap junction_Homo sapiens_hsa045401.25093567
36Glioma_Homo sapiens_hsa052141.23136240
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21569999
38Collecting duct acid secretion_Homo sapiens_hsa049661.20300630
39Dorso-ventral axis formation_Homo sapiens_hsa043201.18697598
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16396004
41Acute myeloid leukemia_Homo sapiens_hsa052211.14560070
42ErbB signaling pathway_Homo sapiens_hsa040121.11335589
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.10696156
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10143663
45TNF signaling pathway_Homo sapiens_hsa046681.09416053
46cAMP signaling pathway_Homo sapiens_hsa040241.06761330
47Calcium signaling pathway_Homo sapiens_hsa040201.06680792
48Leishmaniasis_Homo sapiens_hsa051401.02814596
49Hepatitis C_Homo sapiens_hsa051601.02565718
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02467930
51Axon guidance_Homo sapiens_hsa043601.00771681
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99901138
53mTOR signaling pathway_Homo sapiens_hsa041500.99237906
54Pertussis_Homo sapiens_hsa051330.99123707
55Bladder cancer_Homo sapiens_hsa052190.99073455
56Proteoglycans in cancer_Homo sapiens_hsa052050.98653203
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.97124232
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96921595
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96708983
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93872907
61Toxoplasmosis_Homo sapiens_hsa051450.93246688
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91894718
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91268758
64Focal adhesion_Homo sapiens_hsa045100.89697746
65Endometrial cancer_Homo sapiens_hsa052130.89617650
66Rheumatoid arthritis_Homo sapiens_hsa053230.88744350
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.88622358
68VEGF signaling pathway_Homo sapiens_hsa043700.88072067
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88021839
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86597600
71Thyroid cancer_Homo sapiens_hsa052160.85624682
72Malaria_Homo sapiens_hsa051440.83985642
73Choline metabolism in cancer_Homo sapiens_hsa052310.83980782
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83289434
75AMPK signaling pathway_Homo sapiens_hsa041520.82911715
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.81899781
77Endocytosis_Homo sapiens_hsa041440.81746798
78Melanogenesis_Homo sapiens_hsa049160.81585708
79MAPK signaling pathway_Homo sapiens_hsa040100.80695099
80Notch signaling pathway_Homo sapiens_hsa043300.80017114
81Insulin resistance_Homo sapiens_hsa049310.79681410
82Renal cell carcinoma_Homo sapiens_hsa052110.77950467
83Staphylococcus aureus infection_Homo sapiens_hsa051500.76908332
84Sphingolipid metabolism_Homo sapiens_hsa006000.76855428
85Lysosome_Homo sapiens_hsa041420.76438932
86Chemokine signaling pathway_Homo sapiens_hsa040620.75976623
87Vibrio cholerae infection_Homo sapiens_hsa051100.75357789
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75087611
89Pancreatic secretion_Homo sapiens_hsa049720.74054704
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.73978551
91Colorectal cancer_Homo sapiens_hsa052100.72973190
92Oocyte meiosis_Homo sapiens_hsa041140.70885156
93Hepatitis B_Homo sapiens_hsa051610.70868201
94HIF-1 signaling pathway_Homo sapiens_hsa040660.69307273
95Influenza A_Homo sapiens_hsa051640.69092892
96Osteoclast differentiation_Homo sapiens_hsa043800.68516764
97Legionellosis_Homo sapiens_hsa051340.67752066
98Tuberculosis_Homo sapiens_hsa051520.67740618
99Non-small cell lung cancer_Homo sapiens_hsa052230.67045858
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.66828647
101Prolactin signaling pathway_Homo sapiens_hsa049170.66749862
102Prion diseases_Homo sapiens_hsa050200.66672261
103Thyroid hormone synthesis_Homo sapiens_hsa049180.66474188
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65562809
105B cell receptor signaling pathway_Homo sapiens_hsa046620.65242394
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63735733
107Prostate cancer_Homo sapiens_hsa052150.63660707
108Inositol phosphate metabolism_Homo sapiens_hsa005620.63590232
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.63482700
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63292741
111Adherens junction_Homo sapiens_hsa045200.62603624
112PPAR signaling pathway_Homo sapiens_hsa033200.62083856
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60679126
114ECM-receptor interaction_Homo sapiens_hsa045120.60051415
115Rap1 signaling pathway_Homo sapiens_hsa040150.59714459
116Type I diabetes mellitus_Homo sapiens_hsa049400.59696069
117Dilated cardiomyopathy_Homo sapiens_hsa054140.59664071
118Salmonella infection_Homo sapiens_hsa051320.59196922
119Ras signaling pathway_Homo sapiens_hsa040140.59140077
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58377283
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56354879
122Insulin signaling pathway_Homo sapiens_hsa049100.56192088
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55713016
124Nitrogen metabolism_Homo sapiens_hsa009100.55265342
125FoxO signaling pathway_Homo sapiens_hsa040680.55201546
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55080525
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54714532
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53160694
129Chronic myeloid leukemia_Homo sapiens_hsa052200.53075922
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.49942228
131Phagosome_Homo sapiens_hsa041450.49249753
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47744286
133Platelet activation_Homo sapiens_hsa046110.47623523
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47362914
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47362436
136Pancreatic cancer_Homo sapiens_hsa052120.46881370

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