TBC1D9B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.86854905
2locomotory exploration behavior (GO:0035641)4.62791762
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.25070559
4sodium ion export (GO:0071436)4.14955828
5synaptic vesicle docking involved in exocytosis (GO:0016081)3.91902321
6activation of protein kinase A activity (GO:0034199)3.85628177
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.76351051
8negative regulation of erythrocyte differentiation (GO:0045647)3.70181205
9regulation of synapse structural plasticity (GO:0051823)3.70112034
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.69362933
11positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.61884073
12glutamate secretion (GO:0014047)3.53183955
13barbed-end actin filament capping (GO:0051016)3.53183367
14cellular potassium ion homeostasis (GO:0030007)3.48219914
15adherens junction assembly (GO:0034333)3.47006959
16negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.44745493
17regulation of synaptic vesicle exocytosis (GO:2000300)3.43103172
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.42399998
19semaphorin-plexin signaling pathway (GO:0071526)3.41270489
20protein retention in ER lumen (GO:0006621)3.41083392
21regulation of ARF protein signal transduction (GO:0032012)3.40309482
22focal adhesion assembly (GO:0048041)3.32923564
23cell-substrate adherens junction assembly (GO:0007045)3.32923564
24regulation of early endosome to late endosome transport (GO:2000641)3.29700622
25synaptic vesicle exocytosis (GO:0016079)3.27298044
26cell-substrate junction assembly (GO:0007044)3.27149878
27glycine transport (GO:0015816)3.25124526
28neurotransmitter secretion (GO:0007269)3.20609178
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.20226925
30cytoskeletal anchoring at plasma membrane (GO:0007016)3.16868045
31negative regulation of fatty acid transport (GO:2000192)3.16554060
32basement membrane organization (GO:0071711)3.16429684
33regulation of neuronal synaptic plasticity (GO:0048168)3.15960529
34positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.14476113
35regulation of synaptic vesicle transport (GO:1902803)3.10555701
36cell communication by electrical coupling (GO:0010644)3.07468488
37potassium ion import (GO:0010107)3.07214125
38regulation of glucose import in response to insulin stimulus (GO:2001273)3.06662236
39endothelial cell chemotaxis (GO:0035767)3.04513167
40activation of Rac GTPase activity (GO:0032863)3.04212227
41proline transport (GO:0015824)3.02177512
42layer formation in cerebral cortex (GO:0021819)3.01446498
43vocalization behavior (GO:0071625)3.00193263
44epithelial cell differentiation involved in prostate gland development (GO:0060742)2.99645926
45regulation of long-term neuronal synaptic plasticity (GO:0048169)2.99448932
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.95699638
47hemidesmosome assembly (GO:0031581)2.93217771
48regulation of glutamate receptor signaling pathway (GO:1900449)2.92481291
49prepulse inhibition (GO:0060134)2.92162154
50positive regulation of receptor recycling (GO:0001921)2.89636308
51epithelial cell-cell adhesion (GO:0090136)2.89393338
52neuromuscular process controlling balance (GO:0050885)2.88473212
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.88436938
54alanine transport (GO:0032328)2.87969927
55exploration behavior (GO:0035640)2.87383189
56regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.82511357
57desmosome organization (GO:0002934)2.80490093
58cell-cell junction maintenance (GO:0045217)2.80316540
59gamma-aminobutyric acid transport (GO:0015812)2.79656782
60adenosine receptor signaling pathway (GO:0001973)2.79244266
61regulation of ARF GTPase activity (GO:0032312)2.79088918
62skin morphogenesis (GO:0043589)2.77316021
63insulin-like growth factor receptor signaling pathway (GO:0048009)2.76650707
64cellular sodium ion homeostasis (GO:0006883)2.76390326
65positive regulation of blood vessel endothelial cell migration (GO:0043536)2.75162527
66regulation of extracellular matrix disassembly (GO:0010715)2.71140734
67cerebellar Purkinje cell layer development (GO:0021680)2.69793844
68regulation of cholesterol homeostasis (GO:2000188)2.69034674
69neuromuscular process controlling posture (GO:0050884)2.68668645
70response to laminar fluid shear stress (GO:0034616)2.64953591
71dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.63111988
72maternal placenta development (GO:0001893)2.63029771
73neuronal action potential propagation (GO:0019227)2.61706224
74regulation of clathrin-mediated endocytosis (GO:2000369)2.61349103
75positive regulation of extracellular matrix organization (GO:1903055)2.58872392
76planar cell polarity pathway involved in neural tube closure (GO:0090179)2.58529085
77regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.56962623
78mannose metabolic process (GO:0006013)2.56599701
79dendritic spine morphogenesis (GO:0060997)2.56487793
80potassium ion homeostasis (GO:0055075)2.55889491
81apoptotic cell clearance (GO:0043277)2.55308411
82vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.52901846
83apoptotic process involved in morphogenesis (GO:0060561)2.52721894
84stress fiber assembly (GO:0043149)2.51689364
85regulation of cholesterol biosynthetic process (GO:0045540)2.51554666
86regulation of mammary gland epithelial cell proliferation (GO:0033599)2.50889104
87proline biosynthetic process (GO:0006561)2.50756103
88cortical actin cytoskeleton organization (GO:0030866)2.50719739
89positive regulation of Cdc42 GTPase activity (GO:0043089)2.50486086
90alpha-linolenic acid metabolic process (GO:0036109)2.49250740
91activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.47957844
92positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.47612574
93pinocytosis (GO:0006907)2.47569169
94mating behavior (GO:0007617)2.46848946
95protein localization to endosome (GO:0036010)2.44464657
96glucose 6-phosphate metabolic process (GO:0051156)2.44249509
97cell communication involved in cardiac conduction (GO:0086065)2.44204392
98positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.43635506
99vesicle transport along microtubule (GO:0047496)2.42705401
100negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41963932
101vascular endothelial growth factor signaling pathway (GO:0038084)2.38739076
102positive regulation of Rap GTPase activity (GO:0032854)2.37943449
103positive regulation of protein dephosphorylation (GO:0035307)2.37306856
104dicarboxylic acid biosynthetic process (GO:0043650)2.37080686
105low-density lipoprotein particle clearance (GO:0034383)2.36997187
106regulation of neurotransmitter levels (GO:0001505)2.35713655
107neurotransmitter transport (GO:0006836)2.35272088
108nerve growth factor signaling pathway (GO:0038180)2.34840351
109regulation of NFAT protein import into nucleus (GO:0051532)2.34289852
110myelin maintenance (GO:0043217)2.33334699
111cell volume homeostasis (GO:0006884)2.33104203
112long-term memory (GO:0007616)2.33025048
113regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31993919
114regulation of synaptic plasticity (GO:0048167)2.31858504
115cAMP biosynthetic process (GO:0006171)2.31837313
116ionotropic glutamate receptor signaling pathway (GO:0035235)2.31153272
117positive regulation of nuclease activity (GO:0032075)2.30525507
118adhesion of symbiont to host (GO:0044406)2.29805119
119positive regulation of synaptic transmission, GABAergic (GO:0032230)2.29795610
120negative regulation of cell size (GO:0045792)2.29739335
121regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.29713481
122regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.29287514
123regulation of amyloid precursor protein catabolic process (GO:1902991)2.29106035
124negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.29041824
125regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.28709159
126amyloid precursor protein catabolic process (GO:0042987)2.28634107
127positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.28443942
128positive regulation of membrane potential (GO:0045838)2.28312788
129COPI coating of Golgi vesicle (GO:0048205)2.28017144
130Golgi transport vesicle coating (GO:0048200)2.28017144
131neurotransmitter-gated ion channel clustering (GO:0072578)2.27217713
132actin filament bundle organization (GO:0061572)2.27178247
133actin filament bundle assembly (GO:0051017)2.27178247
134regulation of Rap GTPase activity (GO:0032317)2.26708733
135protein targeting to plasma membrane (GO:0072661)2.26657094
136cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.26136820
137membrane depolarization during action potential (GO:0086010)2.25992381
138branching involved in mammary gland duct morphogenesis (GO:0060444)2.25127117
139regulation of excitatory postsynaptic membrane potential (GO:0060079)2.25119072
140negative regulation of myotube differentiation (GO:0010832)2.24550839
141regulation of extracellular matrix organization (GO:1903053)2.24381699
142modulation by virus of host morphology or physiology (GO:0019048)2.23705388
143cerebellar Purkinje cell differentiation (GO:0021702)2.22881606
144membrane repolarization (GO:0086009)2.22223889
145adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.21563252
146regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.21095869
147cortical cytoskeleton organization (GO:0030865)2.20985148
148peptidyl-proline hydroxylation (GO:0019511)2.19539412
149embryonic process involved in female pregnancy (GO:0060136)2.19038630
150response to auditory stimulus (GO:0010996)2.18489362
151regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.18230007
152positive regulation of vesicle fusion (GO:0031340)2.18139920
153suckling behavior (GO:0001967)2.18029162
154activation of JUN kinase activity (GO:0007257)2.17773620
155endocytic recycling (GO:0032456)2.17768873
156L-amino acid import (GO:0043092)2.17245777
157regulation of beta-amyloid formation (GO:1902003)2.16551524
158plasma membrane repair (GO:0001778)2.16308914
159modulation by symbiont of host cellular process (GO:0044068)2.15865351
160regulation of fatty acid beta-oxidation (GO:0031998)2.15826169
161endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.15615955
162dopamine receptor signaling pathway (GO:0007212)2.14885470
163regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.14865308
164regulation of dendritic spine morphogenesis (GO:0061001)2.14377751
165regulation of sodium ion transmembrane transporter activity (GO:2000649)2.14341998
166peptidyl-tyrosine autophosphorylation (GO:0038083)2.13664242
167positive regulation of sodium ion transport (GO:0010765)2.13189418
168cellular response to glucagon stimulus (GO:0071377)2.12920892
169negative regulation of sodium ion transport (GO:0010766)2.12830361
170positive regulation of fibroblast migration (GO:0010763)2.12640548
171vesicle coating (GO:0006901)2.12529158
172retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.11776714
173response to fluid shear stress (GO:0034405)2.11405614
174signal complex assembly (GO:0007172)2.11078017
175pentose-phosphate shunt (GO:0006098)2.10885930
176endoplasmic reticulum unfolded protein response (GO:0030968)2.10324583
177glucose catabolic process (GO:0006007)2.10023111
178positive regulation of histone deacetylation (GO:0031065)2.09785718
179intracellular estrogen receptor signaling pathway (GO:0030520)2.09107259
180regulation of postsynaptic membrane potential (GO:0060078)2.08989729
181positive regulation of neurotransmitter transport (GO:0051590)2.08677878
182regulation of sodium ion transport (GO:0002028)2.07516217
183surfactant homeostasis (GO:0043129)2.06837871
184cellular response to catecholamine stimulus (GO:0071870)2.05516189
185cellular response to monoamine stimulus (GO:0071868)2.05516189

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.80307762
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.51108728
3DROSHA_22980978_ChIP-Seq_HELA_Human2.49825239
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.43537663
5VDR_21846776_ChIP-Seq_THP-1_Human2.37036299
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35324720
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26359004
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.22198877
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.17249527
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98629074
11KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98502410
12MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89996310
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89991122
14IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89927011
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89503593
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.88648436
17EZH2_22144423_ChIP-Seq_EOC_Human1.87229619
18KDM2B_26808549_Chip-Seq_K562_Human1.86283547
19* LXR_22292898_ChIP-Seq_THP-1_Human1.84991408
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82387235
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78776934
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78668230
23EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76633578
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76633578
25RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.75857418
26DNAJC2_21179169_ChIP-ChIP_NT2_Human1.72149727
27KDM2B_26808549_Chip-Seq_DND41_Human1.70611101
28GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.69420587
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69390369
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.68649898
31* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.68119763
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.65288062
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.62140454
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61865904
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.60394382
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.59883080
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59678831
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56677938
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.56652303
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.55480905
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54119715
42SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53896052
43* LXR_22158963_ChIP-Seq_LIVER_Mouse1.53262787
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52051134
45SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51874765
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51280878
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.50745694
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.50713556
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.48578637
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.48577115
51JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47815430
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44569987
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44340872
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44027495
55REST_21632747_ChIP-Seq_MESCs_Mouse1.43591252
56VDR_24763502_ChIP-Seq_THP-1_Human1.41003327
57KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39867168
58RUNX1_27514584_Chip-Seq_MCF-7_Human1.39383962
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.37901990
60GATA1_19941826_ChIP-Seq_K562_Human1.37498539
61DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36854424
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36281707
63* TCF7_22412390_ChIP-Seq_EML_Mouse1.36151583
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.35971844
65P68_20966046_ChIP-Seq_HELA_Human1.35688573
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.34850060
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34481158
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33629610
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.31641120
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31385214
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29414939
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28684186
73SA1_27219007_Chip-Seq_ERYTHROID_Human1.28374160
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27922643
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26931530
76SPI1_23127762_ChIP-Seq_K562_Human1.25193669
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.23720874
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.23477956
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.22829349
80TP53_22127205_ChIP-Seq_IMR90_Human1.22811297
81CLOCK_20551151_ChIP-Seq_293T_Human1.21069036
82FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20982259
83GATA1_22025678_ChIP-Seq_K562_Human1.20821308
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19032782
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18596413
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18403697
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17914748
88ATF3_27146783_Chip-Seq_COLON_Human1.17885575
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17632447
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17355877
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.17191114
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.16270828
93* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16085612
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15793936
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15162897
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14601925
97RACK7_27058665_Chip-Seq_MCF-7_Human1.14545589
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13421317
99ZNF263_19887448_ChIP-Seq_K562_Human1.12755141
100ELK3_25401928_ChIP-Seq_HUVEC_Human1.10521571
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10354124
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08159881
103UBF1/2_26484160_Chip-Seq_HMECs_Human1.07857513
104GATA2_21666600_ChIP-Seq_HMVEC_Human1.07357120
105CREB1_26743006_Chip-Seq_LNCaP_Human1.07022888
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06602557
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06523525
108SMC4_20622854_ChIP-Seq_HELA_Human1.06139743
109TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.05938043
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05236296
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04488422
112* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04461932
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04383218
114* TBX20_22080862_ChIP-Seq_HEART_Mouse1.02552280
115* TBX20_22328084_ChIP-Seq_HEART_Mouse1.02552280
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02390840
117* RUNX1_22412390_ChIP-Seq_EML_Mouse1.01473325
118NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01278085
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01255146
120SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01207376
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00133502
122NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99576754
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.99139942
124SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99090524
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98984677
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98133891
127* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97772355
128* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97635884
129TP63_22573176_ChIP-Seq_HFKS_Human0.97364555
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.97328533
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96975826
132CTCF_27219007_Chip-Seq_Bcells_Human0.96778292
133CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96635744
134KLF4_19829295_ChIP-Seq_ESCs_Human0.95803761
135MAF_26560356_Chip-Seq_TH1_Human0.95515900
136CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95153897
137GATA2_19941826_ChIP-Seq_K562_Human0.94733032
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94314728
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93749717
140EED_16625203_ChIP-ChIP_MESCs_Mouse0.92819715
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92263144
142GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92060616
143EP300_21415370_ChIP-Seq_HL-1_Mouse0.91603167
144AR_19668381_ChIP-Seq_PC3_Human0.90754537
145MYC_22102868_ChIP-Seq_BL_Human0.90753638
146TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90037956
147ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89467382
148EZH2_27304074_Chip-Seq_ESCs_Mouse0.89168914
149RING1B_27294783_Chip-Seq_ESCs_Mouse0.88590532
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87370899
151TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87367319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.34224285
2MP0002822_catalepsy3.12292873
3MP0002909_abnormal_adrenal_gland3.09686982
4MP0003635_abnormal_synaptic_transmissio2.88432676
5MP0004858_abnormal_nervous_system2.74150844
6MP0003566_abnormal_cell_adhesion2.67424272
7MP0005451_abnormal_body_composition2.53744882
8MP0001849_ear_inflammation2.44540474
9MP0005076_abnormal_cell_differentiation2.43806832
10MP0009780_abnormal_chondrocyte_physiolo2.43776029
11MP0003300_gastrointestinal_ulcer2.39297014
12MP0005409_darkened_coat_color2.27178536
13MP0004270_analgesia2.25822316
14MP0005257_abnormal_intraocular_pressure2.19276011
15MP0009745_abnormal_behavioral_response2.16539842
16MP0002064_seizures2.10251399
17MP0000013_abnormal_adipose_tissue2.08192682
18MP0002063_abnormal_learning/memory/cond2.07231064
19MP0003075_altered_response_to2.05125443
20MP0008961_abnormal_basal_metabolism2.04568014
21MP0004130_abnormal_muscle_cell2.02912214
22MP0003329_amyloid_beta_deposits2.01957570
23MP0003705_abnormal_hypodermis_morpholog2.00161888
24MP0003091_abnormal_cell_migration1.99057405
25MP0008260_abnormal_autophagy1.98135232
26MP0003279_aneurysm1.96899001
27MP0010234_abnormal_vibrissa_follicle1.90124417
28MP0005167_abnormal_blood-brain_barrier1.87969909
29MP0003172_abnormal_lysosome_physiology1.85600388
30MP0001968_abnormal_touch/_nociception1.81529578
31MP0003690_abnormal_glial_cell1.79455335
32MP0003303_peritoneal_inflammation1.78434988
33MP0003453_abnormal_keratinocyte_physiol1.76819975
34MP0005275_abnormal_skin_tensile1.76090309
35MP0005058_abnormal_lysosome_morphology1.74440800
36MP0009046_muscle_twitch1.74422695
37MP0004272_abnormal_basement_membrane1.69395708
38MP0008569_lethality_at_weaning1.63900890
39MP0001348_abnormal_lacrimal_gland1.60656228
40MP0002796_impaired_skin_barrier1.59278543
41MP0002837_dystrophic_cardiac_calcinosis1.59212949
42MP0001501_abnormal_sleep_pattern1.59063019
43MP0002877_abnormal_melanocyte_morpholog1.57802278
44MP0003191_abnormal_cellular_cholesterol1.57502032
45MP0003633_abnormal_nervous_system1.55210548
46MP0002060_abnormal_skin_morphology1.54305883
47MP0000604_amyloidosis1.51128904
48MP0010329_abnormal_lipoprotein_level1.50583758
49MP0004885_abnormal_endolymph1.49522236
50MP0002572_abnormal_emotion/affect_behav1.48297215
51MP0003283_abnormal_digestive_organ1.48000680
52MP0002272_abnormal_nervous_system1.47438843
53MP0000751_myopathy1.43906535
54MP0002733_abnormal_thermal_nociception1.40801563
55MP0005365_abnormal_bile_salt1.39661370
56MP0004811_abnormal_neuron_physiology1.39634150
57MP0002896_abnormal_bone_mineralization1.39229154
58MP0009278_abnormal_bone_marrow1.38968634
59MP0002139_abnormal_hepatobiliary_system1.38449362
60MP0003880_abnormal_central_pattern1.36768261
61MP0000537_abnormal_urethra_morphology1.36738220
62MP0004510_myositis1.36376433
63MP0002734_abnormal_mechanical_nocicepti1.34509536
64MP0003045_fibrosis1.34445652
65MP0001970_abnormal_pain_threshold1.31783419
66MP0005023_abnormal_wound_healing1.31236328
67MP0000003_abnormal_adipose_tissue1.30350096
68MP0009840_abnormal_foam_cell1.29587396
69MP0005535_abnormal_body_temperature1.28415426
70MP0008874_decreased_physiological_sensi1.27345203
71MP0000569_abnormal_digit_pigmentation1.27018230
72MP0002998_abnormal_bone_remodeling1.26694183
73MP0001486_abnormal_startle_reflex1.26009483
74MP0002736_abnormal_nociception_after1.25926815
75MP0005360_urolithiasis1.25390742
76MP0004947_skin_inflammation1.23530948
77MP0000767_abnormal_smooth_muscle1.22615571
78MP0002249_abnormal_larynx_morphology1.21877883
79MP0005670_abnormal_white_adipose1.19378640
80MP0002735_abnormal_chemical_nociception1.16842381
81MP0009384_cardiac_valve_regurgitation1.14785836
82MP0000733_abnormal_muscle_development1.12131733
83MP0003879_abnormal_hair_cell1.10554736
84MP0003436_decreased_susceptibility_to1.09930544
85MP0005503_abnormal_tendon_morphology1.09679083
86MP0005083_abnormal_biliary_tract1.09231067
87MP0005501_abnormal_skin_physiology1.06280457
88MP0000678_abnormal_parathyroid_gland1.05375495
89MP0002090_abnormal_vision1.05278663
90MP0002118_abnormal_lipid_homeostasis1.04525782
91MP0003631_nervous_system_phenotype1.03895861
92MP0005584_abnormal_enzyme/coenzyme_acti1.03062551
93MP0000858_altered_metastatic_potential1.01883306
94MP0005375_adipose_tissue_phenotype1.01016742
95MP0005166_decreased_susceptibility_to1.00826086
96MP0005623_abnormal_meninges_morphology1.00096089
97MP0000681_abnormal_thyroid_gland0.99977148
98MP0005085_abnormal_gallbladder_physiolo0.99923334
99MP0003252_abnormal_bile_duct0.99011294
100MP0005423_abnormal_somatic_nervous0.98852099
101MP0001765_abnormal_ion_homeostasis0.97457489
102MP0004782_abnormal_surfactant_physiolog0.97219352
103MP0004381_abnormal_hair_follicle0.96924235
104MP0005508_abnormal_skeleton_morphology0.93527463
105MP0004264_abnormal_extraembryonic_tissu0.92991786
106MP0000747_muscle_weakness0.91780111
107MP0004924_abnormal_behavior0.89652958
108MP0005386_behavior/neurological_phenoty0.89652958
109MP0002067_abnormal_sensory_capabilities0.89424066
110MP0002078_abnormal_glucose_homeostasis0.89163142
111MP0008872_abnormal_physiological_respon0.86237604
112MP0000955_abnormal_spinal_cord0.85856238
113MP0002971_abnormal_brown_adipose0.85570717
114MP0001958_emphysema0.84766032
115MP0004233_abnormal_muscle_weight0.84454303
116MP0005621_abnormal_cell_physiology0.84436143
117MP0001440_abnormal_grooming_behavior0.84332245
118MP0000467_abnormal_esophagus_morphology0.83549539
119MP0000920_abnormal_myelination0.82905103
120MP0000579_abnormal_nail_morphology0.82784769
121MP0001851_eye_inflammation0.80848634
122MP0000462_abnormal_digestive_system0.80761605
123MP0004043_abnormal_pH_regulation0.80512917
124MP0002066_abnormal_motor_capabilities/c0.80315532
125MP0001533_abnormal_skeleton_physiology0.80072957
126MP0004084_abnormal_cardiac_muscle0.79894521
127MP0001216_abnormal_epidermal_layer0.79590895
128MP0004036_abnormal_muscle_relaxation0.78663880
129MP0001915_intracranial_hemorrhage0.77738779
130MP0010352_gastrointestinal_tract_polyps0.77240974
131MP0005646_abnormal_pituitary_gland0.76249924
132MP0005666_abnormal_adipose_tissue0.74958283
133MP0003634_abnormal_glial_cell0.74939698
134MP0004085_abnormal_heartbeat0.74752686
135MP0002557_abnormal_social/conspecific_i0.74638744
136MP0005390_skeleton_phenotype0.73715459
137MP0004087_abnormal_muscle_fiber0.73457400
138MP0000759_abnormal_skeletal_muscle0.73417960
139MP0003828_pulmonary_edema0.72991076
140MP0002098_abnormal_vibrissa_morphology0.72925490
141MP0002089_abnormal_postnatal_growth/wei0.72684373
142MP0002970_abnormal_white_adipose0.72437569
143MP0010368_abnormal_lymphatic_system0.71985284
144MP0003183_abnormal_peptide_metabolism0.71936670
145MP0005464_abnormal_platelet_physiology0.71793781
146MP0000534_abnormal_ureter_morphology0.71261386
147MP0002069_abnormal_eating/drinking_beha0.71194605
148MP0008438_abnormal_cutaneous_collagen0.70616969
149MP0006138_congestive_heart_failure0.70584046
150MP0001756_abnormal_urination0.69871918
151MP0001177_atelectasis0.68950486
152MP0002269_muscular_atrophy0.68142595
153MP0008875_abnormal_xenobiotic_pharmacok0.68117420
154MP0004185_abnormal_adipocyte_glucose0.67949548
155MP0002009_preneoplasia0.67844567
156MP0009931_abnormal_skin_appearance0.67759910
157MP0010630_abnormal_cardiac_muscle0.65261236
158MP0010771_integument_phenotype0.65053312
159MP0005595_abnormal_vascular_smooth0.64468449
160MP0000377_abnormal_hair_follicle0.61653525
161MP0002166_altered_tumor_susceptibility0.61500309
162MP0003115_abnormal_respiratory_system0.61152325

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.24098317
2Protrusio acetabuli (HP:0003179)3.89367149
3Premature rupture of membranes (HP:0001788)3.59793636
4Visual hallucinations (HP:0002367)3.47540672
5Action tremor (HP:0002345)3.19296332
6Focal motor seizures (HP:0011153)3.17261006
7Broad face (HP:0000283)3.16731773
8Supranuclear gaze palsy (HP:0000605)3.15836012
9Papilledema (HP:0001085)3.09643589
10Focal seizures (HP:0007359)2.97884902
11Vertebral compression fractures (HP:0002953)2.97095672
12Cervical subluxation (HP:0003308)2.93262449
13Obstructive sleep apnea (HP:0002870)2.89475303
14Hemiplegia (HP:0002301)2.79364164
15Cerebral aneurysm (HP:0004944)2.79066414
16Postural instability (HP:0002172)2.76952388
17Depression (HP:0000716)2.76101293
18Bundle branch block (HP:0011710)2.73468398
19J-shaped sella turcica (HP:0002680)2.70723460
20Upper limb amyotrophy (HP:0009129)2.63142859
21Distal upper limb amyotrophy (HP:0007149)2.63142859
22Increased connective tissue (HP:0009025)2.61679450
23Shallow orbits (HP:0000586)2.59992996
24Ankle clonus (HP:0011448)2.59676146
25Thin bony cortex (HP:0002753)2.59488024
26Flat acetabular roof (HP:0003180)2.53488038
27Torticollis (HP:0000473)2.53349293
28Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.51407850
29Hyperacusis (HP:0010780)2.48527849
30Abnormality of the lower motor neuron (HP:0002366)2.47809934
31Dysmetric saccades (HP:0000641)2.42563727
32Ulnar bowing (HP:0003031)2.41699491
33Enlarged penis (HP:0000040)2.39766335
34Insomnia (HP:0100785)2.37151710
35Atrophic scars (HP:0001075)2.36586747
36Impaired social interactions (HP:0000735)2.36493398
37Abnormal social behavior (HP:0012433)2.36493398
38Distal lower limb amyotrophy (HP:0008944)2.35966386
39Dysostosis multiplex (HP:0000943)2.35142934
40Ventricular fibrillation (HP:0001663)2.33769851
41Resting tremor (HP:0002322)2.33667699
42Macroorchidism (HP:0000053)2.33507505
43Deep venous thrombosis (HP:0002625)2.33065737
44Fragile skin (HP:0001030)2.32166531
45Increased cerebral lipofuscin (HP:0011813)2.30988337
46Annular pancreas (HP:0001734)2.29545418
47Intention tremor (HP:0002080)2.28782684
48Mucopolysacchariduria (HP:0008155)2.26708891
49Urinary glycosaminoglycan excretion (HP:0003541)2.26708891
50Hand muscle atrophy (HP:0009130)2.26681946
51Hypercortisolism (HP:0001578)2.23258357
52Urinary urgency (HP:0000012)2.23202755
53Focal dystonia (HP:0004373)2.22114818
54Wormian bones (HP:0002645)2.22101394
55Mitral regurgitation (HP:0001653)2.22051167
56Impaired vibration sensation in the lower limbs (HP:0002166)2.21868419
57Short nail (HP:0001799)2.19679644
58Craniofacial dystonia (HP:0012179)2.18239379
59Poor eye contact (HP:0000817)2.17321222
60Blue sclerae (HP:0000592)2.16013223
61Pointed chin (HP:0000307)2.15352176
62Generalized tonic-clonic seizures (HP:0002069)2.14797940
63Vascular tortuosity (HP:0004948)2.14731764
64Spinal rigidity (HP:0003306)2.14691093
65Arterial tortuosity (HP:0005116)2.14039157
66Urinary bladder sphincter dysfunction (HP:0002839)2.10822442
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10319891
68Abnormality of polysaccharide metabolism (HP:0011012)2.10319891
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10319891
70Abnormality of the Achilles tendon (HP:0005109)2.09835825
71Bladder diverticulum (HP:0000015)2.09525761
72Achilles tendon contracture (HP:0001771)2.09105926
73Axonal loss (HP:0003447)2.08036617
74Advanced eruption of teeth (HP:0006288)2.08019610
75Striae distensae (HP:0001065)2.07779908
76Distal lower limb muscle weakness (HP:0009053)2.05896233
77Anxiety (HP:0000739)2.05485281
78Disproportionate tall stature (HP:0001519)2.04479734
79Polygenic inheritance (HP:0010982)2.03162416
80Abnormality of glycolipid metabolism (HP:0010969)2.02623187
81Abnormality of liposaccharide metabolism (HP:0010968)2.02623187
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.02623187
83Asymmetry of the thorax (HP:0001555)2.02466717
84Rapidly progressive (HP:0003678)2.02261519
85Long toe (HP:0010511)2.02120570
86Biconcave vertebral bodies (HP:0004586)2.01944186
87Abnormal eating behavior (HP:0100738)2.01065221
88Increased variability in muscle fiber diameter (HP:0003557)1.99959828
89Lymphangioma (HP:0100764)1.98783362
90Nuclear cataract (HP:0100018)1.98716519
91Centrally nucleated skeletal muscle fibers (HP:0003687)1.97918187
92Atonic seizures (HP:0010819)1.97206181
93Premature skin wrinkling (HP:0100678)1.96811843
94Complement deficiency (HP:0004431)1.95664927
95Agitation (HP:0000713)1.94837899
96Osteolytic defects of the phalanges of the hand (HP:0009771)1.93756749
97Osteolytic defects of the hand bones (HP:0009699)1.93756749
98Cerebral inclusion bodies (HP:0100314)1.93597190
99Neuronal loss in central nervous system (HP:0002529)1.93362932
100Hemorrhage of the eye (HP:0011885)1.92501964
101Broad metatarsal (HP:0001783)1.92113640
102Dilatation of the ascending aorta (HP:0005111)1.91241066
103Global brain atrophy (HP:0002283)1.90684546
104Lower limb asymmetry (HP:0100559)1.90625579
105Truncal ataxia (HP:0002078)1.90240417
106Atrioventricular block (HP:0001678)1.90236389
107Status epilepticus (HP:0002133)1.90217814
108Dysdiadochokinesis (HP:0002075)1.89817673
109Absence seizures (HP:0002121)1.89570102
110Asymmetric septal hypertrophy (HP:0001670)1.89133177
111Aneurysm (HP:0002617)1.87965790
112Mildly elevated creatine phosphokinase (HP:0008180)1.87092475
113Increased CSF protein (HP:0002922)1.86717631
114Hyperparathyroidism (HP:0000843)1.86445177
115Genu recurvatum (HP:0002816)1.86322792
116Heart block (HP:0012722)1.85105065
117Elfin facies (HP:0004428)1.85103550
118Back pain (HP:0003418)1.84815345
119Stridor (HP:0010307)1.84375796
120Scanning speech (HP:0002168)1.84261894
121Dysmetria (HP:0001310)1.83893452
122Neurofibrillary tangles (HP:0002185)1.83382257
123Natal tooth (HP:0000695)1.81992322
124Aortic aneurysm (HP:0004942)1.81799398
125Aortic dissection (HP:0002647)1.81711566
126Abnormality of the distal phalanx of the thumb (HP:0009617)1.81140050
127Deformed sella turcica (HP:0002681)1.80599762
128Abnormality of the periventricular white matter (HP:0002518)1.80037451
129Ketoacidosis (HP:0001993)1.79757300
130Mitral valve prolapse (HP:0001634)1.78927648
131Abnormality of the distal phalanges of the toes (HP:0010182)1.78781001
132Bradykinesia (HP:0002067)1.78395553
133Bronchomalacia (HP:0002780)1.77797291
134Ankle contracture (HP:0006466)1.77634121
135Abnormal ossification of hand bones (HP:0005921)1.77480039
136Abnormality of carpal bone ossification (HP:0006257)1.77306355
137Spinal canal stenosis (HP:0003416)1.76838945
138Abnormality of the thoracic spine (HP:0100711)1.76547767
139Loss of speech (HP:0002371)1.76228400
140Impaired smooth pursuit (HP:0007772)1.74848416
141Ankyloglossia (HP:0010296)1.74540601
142Turricephaly (HP:0000262)1.73638820
143Mutism (HP:0002300)1.73511012
144Lower limb amyotrophy (HP:0007210)1.72655273
145Long palpebral fissure (HP:0000637)1.72529616
146Abnormal atrioventricular conduction (HP:0005150)1.72242125
147Spinal cord compression (HP:0002176)1.72130233
148Mitral stenosis (HP:0001718)1.71702895
149Hematochezia (HP:0002573)1.71284007
150Insidious onset (HP:0003587)1.69388983
151Termporal pattern (HP:0011008)1.69388983
152Germ cell neoplasia (HP:0100728)1.68771403
153Hyperextensible skin (HP:0000974)1.68423715
154Ketosis (HP:0001946)1.68278109
155Bowel diverticulosis (HP:0005222)1.67967900
156Neonatal onset (HP:0003623)1.67836482
157Xanthomatosis (HP:0000991)1.67245821
158Abnormality of skeletal muscle fiber size (HP:0012084)1.66814619
159Interstitial pulmonary disease (HP:0006530)1.66040643
160Postural tremor (HP:0002174)1.65893073
161Joint laxity (HP:0001388)1.65618193
162Pheochromocytoma (HP:0002666)1.65348287
163Megalencephaly (HP:0001355)1.64900788
164Abnormality of complement system (HP:0005339)1.64563301
165Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.64196555
166Spondylolisthesis (HP:0003302)1.64039729
167Hammertoe (HP:0001765)1.63240226
168Congenital glaucoma (HP:0001087)1.63087591
169Joint stiffness (HP:0001387)1.63030386
170Neoplasm of the peripheral nervous system (HP:0100007)1.62224389
171Coxa vara (HP:0002812)1.61182158
172Increased neuronal autofluorescent lipopigment (HP:0002074)1.59915846

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.91223019
2PRPF4B2.93663643
3SMG12.87725440
4MAP3K92.74377085
5PRKD32.63895405
6IRAK32.57061710
7ICK2.56047687
8PKN22.53968424
9CAMKK12.47290958
10DAPK22.41099562
11NTRK32.39024836
12RIPK12.34116425
13EPHA42.32129820
14KSR22.31066255
15CDK122.20815882
16LMTK22.10991609
17NTRK12.08587343
18EEF2K1.88605202
19EPHA21.76056624
20ERN11.72130257
21PAK61.69549541
22MINK11.69351117
23MAP3K21.64909773
24PRKCH1.54409476
25MAP3K131.51705419
26PDGFRA1.47434074
27RET1.46923121
28CAMKK21.43022208
29FES1.41853499
30SCYL21.41174895
31MAP3K41.38301629
32TAOK11.36126136
33RIPK41.32055973
34STK381.32026659
35TESK11.27404455
36MAP2K41.25250177
37MTOR1.22140529
38CAMK1G1.20761133
39PTK61.20436145
40SIK11.20019623
41SIK21.18053511
42LATS21.17828296
43PAK41.15599221
44MAP3K11.13703444
45SGK31.10288179
46ALK1.09612561
47NME21.09465651
48MAP3K71.05562884
49CAMK1D1.05047989
50DAPK11.04677358
51CDK51.03815364
52MST1R1.02864824
53MAP2K31.01237228
54TYRO30.99323729
55JAK10.96824838
56NTRK20.95510214
57DMPK0.95435611
58PDPK10.95048571
59TAOK30.94518472
60FRK0.94383325
61PDK10.92670414
62MAP3K30.88411341
63EPHB10.87303883
64TNK20.86609345
65BMX0.85600372
66TAOK20.85169892
67STK110.83179234
68MAP3K100.82133203
69RPS6KA20.81927609
70TTN0.80838989
71FGFR20.79554060
72CAMK10.78028057
73JAK20.76720459
74ARAF0.76682447
75PIM20.75516671
76UHMK10.74881954
77PAK20.74450266
78MAP3K60.74357189
79TBK10.73065597
80PINK10.72599769
81IRAK20.70220768
82NEK10.69128776
83SGK4940.68991557
84SGK2230.68991557
85MAPK110.67905535
86LRRK20.67387740
87PHKG20.66149715
88PHKG10.66149715
89WNK10.65373350
90FGFR40.62577081
91MAP3K110.61787050
92PTK2B0.61621545
93FGFR30.61395829
94MAPK120.60911672
95RPS6KC10.60722638
96RPS6KL10.60722638
97SGK20.59952570
98CAMK40.59881115
99MAP2K20.59221793
100MARK20.59115964
101MAP3K120.59032171
102HIPK20.58078270
103CDC42BPA0.57676029
104PRKD10.56142490
105PAK30.55828722
106MET0.55454856
107PTK20.53823283
108DAPK30.53424766
109MATK0.53373873
110MAP3K140.51813117
111RAF10.51532081
112ZAP700.51401776
113FER0.51030253
114PDGFRB0.50823180
115MOS0.50756555
116TYK20.50562015
117MAP2K10.50334104
118DDR20.48043865
119FYN0.47944884
120TESK20.46336294
121ILK0.45509067
122MAP2K70.44184314
123BCKDK0.43957626
124CDK60.43768013
125CSF1R0.43354285
126MAPKAPK30.43078035
127SGK10.42368714
128PRKG20.41305068
129KSR10.41274622
130RPS6KB20.40577743
131HCK0.40442728
132GRK50.40122448
133RPS6KA30.39755040
134BRAF0.39364896
135ROCK20.38681500
136TGFBR20.38674825
137NEK90.38403121
138TRPM70.38163289
139IRAK40.38082730
140RPS6KA60.37709232
141ROCK10.37170688
142PRKCG0.36732003
143PRKD20.36521457
144PRKCZ0.36244215
145MAPK100.34108939
146MAPK70.33908013
147MAP3K80.33842315
148NEK60.33655128

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.48109499
2Other glycan degradation_Homo sapiens_hsa005112.82019735
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03632142
4Olfactory transduction_Homo sapiens_hsa047402.02781784
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01559225
6Synaptic vesicle cycle_Homo sapiens_hsa047211.94043180
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.85695908
8Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72109434
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62536996
10Circadian entrainment_Homo sapiens_hsa047131.62140478
11Insulin secretion_Homo sapiens_hsa049111.61787020
12Acute myeloid leukemia_Homo sapiens_hsa052211.56417737
13Gastric acid secretion_Homo sapiens_hsa049711.56111217
14GABAergic synapse_Homo sapiens_hsa047271.53635113
15Notch signaling pathway_Homo sapiens_hsa043301.53079332
16Long-term potentiation_Homo sapiens_hsa047201.52357437
17Salivary secretion_Homo sapiens_hsa049701.46876711
18Type II diabetes mellitus_Homo sapiens_hsa049301.41142815
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40829010
20Morphine addiction_Homo sapiens_hsa050321.39085097
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36826483
22Glutamatergic synapse_Homo sapiens_hsa047241.36505976
23Arginine biosynthesis_Homo sapiens_hsa002201.35040014
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33035113
25Cholinergic synapse_Homo sapiens_hsa047251.32759281
26Amphetamine addiction_Homo sapiens_hsa050311.30989921
27Bile secretion_Homo sapiens_hsa049761.30678003
28Dopaminergic synapse_Homo sapiens_hsa047281.29742773
29Bladder cancer_Homo sapiens_hsa052191.29056632
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24753995
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24096106
32Renin secretion_Homo sapiens_hsa049241.23216055
33Pentose phosphate pathway_Homo sapiens_hsa000301.23145495
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20076688
35ECM-receptor interaction_Homo sapiens_hsa045121.19197771
36Renal cell carcinoma_Homo sapiens_hsa052111.19037915
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18768868
38Glioma_Homo sapiens_hsa052141.17515274
39Fructose and mannose metabolism_Homo sapiens_hsa000511.17369710
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15585210
41Pancreatic cancer_Homo sapiens_hsa052121.15174550
42Cocaine addiction_Homo sapiens_hsa050301.12506674
43Oxytocin signaling pathway_Homo sapiens_hsa049211.09600144
44Estrogen signaling pathway_Homo sapiens_hsa049151.09536279
45Galactose metabolism_Homo sapiens_hsa000521.08876735
46B cell receptor signaling pathway_Homo sapiens_hsa046621.07355730
47Proteoglycans in cancer_Homo sapiens_hsa052051.04666947
48GnRH signaling pathway_Homo sapiens_hsa049121.04190510
49Thyroid cancer_Homo sapiens_hsa052161.01957598
50Nicotine addiction_Homo sapiens_hsa050330.98010702
51Thyroid hormone synthesis_Homo sapiens_hsa049180.97040490
52cAMP signaling pathway_Homo sapiens_hsa040240.96207920
53Vibrio cholerae infection_Homo sapiens_hsa051100.96140539
54Gap junction_Homo sapiens_hsa045400.95515848
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.95461288
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.94652186
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92221297
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.88387380
59Insulin resistance_Homo sapiens_hsa049310.87789619
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87193485
61Inositol phosphate metabolism_Homo sapiens_hsa005620.86972050
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.86936230
63mTOR signaling pathway_Homo sapiens_hsa041500.86639631
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.86407968
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86320330
66Small cell lung cancer_Homo sapiens_hsa052220.85517676
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85433679
68Hepatitis C_Homo sapiens_hsa051600.84989190
69Calcium signaling pathway_Homo sapiens_hsa040200.84221593
70Osteoclast differentiation_Homo sapiens_hsa043800.83399856
71Pancreatic secretion_Homo sapiens_hsa049720.83193205
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82225435
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82217750
74PPAR signaling pathway_Homo sapiens_hsa033200.82177124
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81253011
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.81183774
77Prostate cancer_Homo sapiens_hsa052150.80262719
78Insulin signaling pathway_Homo sapiens_hsa049100.80026764
79Lysine degradation_Homo sapiens_hsa003100.79727741
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.79151671
81Non-small cell lung cancer_Homo sapiens_hsa052230.79084297
82Fatty acid degradation_Homo sapiens_hsa000710.78976882
83Dilated cardiomyopathy_Homo sapiens_hsa054140.78645959
84VEGF signaling pathway_Homo sapiens_hsa043700.77976211
85Dorso-ventral axis formation_Homo sapiens_hsa043200.77707869
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77517145
87Adherens junction_Homo sapiens_hsa045200.74837234
88Long-term depression_Homo sapiens_hsa047300.74478132
89Toxoplasmosis_Homo sapiens_hsa051450.73909486
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73619374
91Glucagon signaling pathway_Homo sapiens_hsa049220.72922577
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71289228
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69258860
94Lysosome_Homo sapiens_hsa041420.69164960
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68891746
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.68626791
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68169331
98HIF-1 signaling pathway_Homo sapiens_hsa040660.67637566
99Fatty acid metabolism_Homo sapiens_hsa012120.67034497
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.66581104
101Platelet activation_Homo sapiens_hsa046110.64769675
102MicroRNAs in cancer_Homo sapiens_hsa052060.64553647
103Prion diseases_Homo sapiens_hsa050200.63614363
104Chronic myeloid leukemia_Homo sapiens_hsa052200.62402986
105ErbB signaling pathway_Homo sapiens_hsa040120.61976852
106TNF signaling pathway_Homo sapiens_hsa046680.61920492
107Endometrial cancer_Homo sapiens_hsa052130.61888746
108Endocytosis_Homo sapiens_hsa041440.61437065
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61095590
110Salmonella infection_Homo sapiens_hsa051320.61062106
111Taste transduction_Homo sapiens_hsa047420.60452095
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.60182411
113Hepatitis B_Homo sapiens_hsa051610.58782837
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58770933
115Colorectal cancer_Homo sapiens_hsa052100.57685014
116ABC transporters_Homo sapiens_hsa020100.57609789
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57527987
118Melanogenesis_Homo sapiens_hsa049160.57503668
119Biosynthesis of amino acids_Homo sapiens_hsa012300.57499789
120Shigellosis_Homo sapiens_hsa051310.55298331
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54887366
122Apoptosis_Homo sapiens_hsa042100.54770355
123Fatty acid biosynthesis_Homo sapiens_hsa000610.54325177
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53572660
125Amoebiasis_Homo sapiens_hsa051460.52966653
126Butanoate metabolism_Homo sapiens_hsa006500.52666034
127Prolactin signaling pathway_Homo sapiens_hsa049170.52039439
128AMPK signaling pathway_Homo sapiens_hsa041520.51773259
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51699594
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51117975
131Rap1 signaling pathway_Homo sapiens_hsa040150.50431694
132Chemokine signaling pathway_Homo sapiens_hsa040620.50294733
133Axon guidance_Homo sapiens_hsa043600.48590382
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48538901
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48465859
136Focal adhesion_Homo sapiens_hsa045100.47433592
137Choline metabolism in cancer_Homo sapiens_hsa052310.46289410
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.46160751
139Starch and sucrose metabolism_Homo sapiens_hsa005000.46008034
140Serotonergic synapse_Homo sapiens_hsa047260.45658363
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44865439

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