TBCA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.51900088
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.46856574
3ATP synthesis coupled proton transport (GO:0015986)7.37751388
4energy coupled proton transport, down electrochemical gradient (GO:0015985)7.37751388
5translational termination (GO:0006415)7.29938115
6ribosomal small subunit assembly (GO:0000028)7.15933337
7ribosomal small subunit biogenesis (GO:0042274)6.86800159
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.64057276
9cotranslational protein targeting to membrane (GO:0006613)6.58908675
10protein targeting to ER (GO:0045047)6.56423056
11protein localization to endoplasmic reticulum (GO:0070972)6.19285341
12establishment of protein localization to endoplasmic reticulum (GO:0072599)6.19272617
13translational elongation (GO:0006414)6.15997642
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.15880192
15respiratory electron transport chain (GO:0022904)5.90557877
16viral life cycle (GO:0019058)5.89313403
17cellular protein complex disassembly (GO:0043624)5.81008319
18protein neddylation (GO:0045116)5.78298143
19electron transport chain (GO:0022900)5.78013169
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.39732215
21translational initiation (GO:0006413)5.25365955
22ribosomal large subunit biogenesis (GO:0042273)5.20807367
23maturation of SSU-rRNA (GO:0030490)5.07076669
24chaperone-mediated protein transport (GO:0072321)4.99644929
25GTP biosynthetic process (GO:0006183)4.88383378
26protein complex disassembly (GO:0043241)4.87349437
27translation (GO:0006412)4.74058965
28sequestering of actin monomers (GO:0042989)4.71570743
29macromolecular complex disassembly (GO:0032984)4.66930978
30establishment of protein localization to mitochondrial membrane (GO:0090151)4.62040242
31protein complex biogenesis (GO:0070271)4.58728550
32proteasome assembly (GO:0043248)4.58259687
33protein targeting to membrane (GO:0006612)4.35391904
34mitochondrial respiratory chain complex assembly (GO:0033108)4.16170575
35mitochondrial respiratory chain complex I assembly (GO:0032981)4.14623264
36NADH dehydrogenase complex assembly (GO:0010257)4.14623264
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.14623264
38UTP biosynthetic process (GO:0006228)4.12915892
39guanosine-containing compound biosynthetic process (GO:1901070)3.87576616
40purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.82527724
41nuclear-transcribed mRNA catabolic process (GO:0000956)3.76124947
42purine nucleoside triphosphate biosynthetic process (GO:0009145)3.75795124
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74792998
44chromatin remodeling at centromere (GO:0031055)3.71050611
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.66596525
46regulation of cellular amino acid metabolic process (GO:0006521)3.66487840
47regulation of mitochondrial translation (GO:0070129)3.64924056
48oxidative phosphorylation (GO:0006119)3.64122750
49UTP metabolic process (GO:0046051)3.63686202
50CTP biosynthetic process (GO:0006241)3.62409883
51CTP metabolic process (GO:0046036)3.62409883
52CENP-A containing nucleosome assembly (GO:0034080)3.62335145
53DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.56826311
54mRNA catabolic process (GO:0006402)3.56188494
55ATP biosynthetic process (GO:0006754)3.52283251
56DNA damage response, detection of DNA damage (GO:0042769)3.51909092
57antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.51496393
58establishment of integrated proviral latency (GO:0075713)3.50774718
59inner mitochondrial membrane organization (GO:0007007)3.49120587
60hydrogen ion transmembrane transport (GO:1902600)3.48958206
61cytochrome complex assembly (GO:0017004)3.47773716
62cullin deneddylation (GO:0010388)3.47025803
63intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.45599874
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.45599874
65respiratory chain complex IV assembly (GO:0008535)3.42366062
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41466113
67ribonucleoside triphosphate biosynthetic process (GO:0009201)3.41237864
68signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39805148
69signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39805148
70signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39805148
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36057949
72negative regulation of ligase activity (GO:0051352)3.36057949
73protein targeting to mitochondrion (GO:0006626)3.34857463
74cellular component biogenesis (GO:0044085)3.31365290
75DNA replication checkpoint (GO:0000076)3.31250099
76ribonucleoprotein complex biogenesis (GO:0022613)3.29412804
77establishment of protein localization to mitochondrion (GO:0072655)3.28926132
78signal transduction involved in DNA damage checkpoint (GO:0072422)3.27827569
79signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27827569
80signal transduction involved in cell cycle checkpoint (GO:0072395)3.26205223
81spliceosomal snRNP assembly (GO:0000387)3.22919658
827-methylguanosine mRNA capping (GO:0006370)3.20287326
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19822170
84protein localization to mitochondrion (GO:0070585)3.19445325
85protein deneddylation (GO:0000338)3.19079435
86aldehyde catabolic process (GO:0046185)3.18279972
877-methylguanosine RNA capping (GO:0009452)3.17837960
88RNA capping (GO:0036260)3.17837960
89RNA catabolic process (GO:0006401)3.16227916
90pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.15465294
91nucleobase-containing small molecule interconversion (GO:0015949)3.15248074
92termination of RNA polymerase III transcription (GO:0006386)3.14889328
93transcription elongation from RNA polymerase III promoter (GO:0006385)3.14889328
94establishment of viral latency (GO:0019043)3.11446993
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09620962
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07296171
97pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.07102799
98histone exchange (GO:0043486)3.05669307
99establishment of protein localization to membrane (GO:0090150)3.05005035
100protein targeting (GO:0006605)3.01489930
101nucleoside diphosphate phosphorylation (GO:0006165)3.01228302
102anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00962888
103proton transport (GO:0015992)3.00250973
104nucleoside triphosphate biosynthetic process (GO:0009142)2.98176845
105water-soluble vitamin biosynthetic process (GO:0042364)2.95506033
106pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.92287918
107hydrogen transport (GO:0006818)2.91603091
108rRNA processing (GO:0006364)2.91225647
109protein-cofactor linkage (GO:0018065)2.91074974
110antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.89779145
111positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89313871
112intracellular protein transmembrane import (GO:0044743)2.86500222
113DNA replication-independent nucleosome assembly (GO:0006336)2.85762821
114DNA replication-independent nucleosome organization (GO:0034724)2.85762821
115mitochondrial transport (GO:0006839)2.81819412
116rRNA metabolic process (GO:0016072)2.77964092
117RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76751374
118tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76751374
119rRNA modification (GO:0000154)2.76583281
120spliceosomal complex assembly (GO:0000245)2.75014127
121pseudouridine synthesis (GO:0001522)2.71180933
122formation of translation preinitiation complex (GO:0001731)2.66438999
123purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.61712098
124purine nucleoside monophosphate biosynthetic process (GO:0009127)2.61712098
125aerobic respiration (GO:0009060)2.56084470
126pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.53638704
127histone mRNA metabolic process (GO:0008334)2.51469170
128regulation of helicase activity (GO:0051095)2.47147080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.81594890
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.77933557
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.36161012
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.26896384
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.26607939
6CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.38394105
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.26444910
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.24861380
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18916992
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.18088935
11ELK1_19687146_ChIP-ChIP_HELA_Human3.16919521
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.15268465
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.14476137
14RBPJ_22232070_ChIP-Seq_NCS_Mouse3.08619912
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.02512558
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.93717619
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.92547189
18DCP1A_22483619_ChIP-Seq_HELA_Human2.63164999
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.55582222
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55537298
21VDR_23849224_ChIP-Seq_CD4+_Human2.54299554
22E2F7_22180533_ChIP-Seq_HELA_Human2.53154946
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52557063
24TTF2_22483619_ChIP-Seq_HELA_Human2.41208007
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38781945
26XRN2_22483619_ChIP-Seq_HELA_Human2.36299596
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.29693848
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.26896775
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22610353
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.15441375
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.11048761
32ELK1_22589737_ChIP-Seq_MCF10A_Human2.06580354
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.04919809
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93039552
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89652272
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86054912
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83694438
38FOXP3_21729870_ChIP-Seq_TREG_Human1.82644549
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.81642739
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74785024
41MYC_18940864_ChIP-ChIP_HL60_Human1.70233879
42VDR_22108803_ChIP-Seq_LS180_Human1.63229358
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.54266275
44ZNF274_21170338_ChIP-Seq_K562_Hela1.51891087
45CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.51731616
46* GABP_19822575_ChIP-Seq_HepG2_Human1.50416239
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.49019607
48IGF1R_20145208_ChIP-Seq_DFB_Human1.48765326
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.45707333
50EZH2_22144423_ChIP-Seq_EOC_Human1.44466727
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43206204
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42260387
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40783948
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40106664
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39550736
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37421129
57AR_21909140_ChIP-Seq_LNCAP_Human1.35945780
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35316912
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33788049
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28670727
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26928663
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26895031
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.25800661
64MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20697822
65FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19480871
66* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18681659
67FOXM1_23109430_ChIP-Seq_U2OS_Human1.15293521
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.15047073
69FUS_26573619_Chip-Seq_HEK293_Human1.14340491
70IRF1_19129219_ChIP-ChIP_H3396_Human1.14202855
71* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14077501
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13610609
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13277725
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13109363
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10598342
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.10140555
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10133564
78* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.08996372
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.06587069
80TAF15_26573619_Chip-Seq_HEK293_Human1.05501117
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03663220
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03598719
83SOX17_20123909_ChIP-Seq_XEN_Mouse1.03240038
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02315533
85EWS_26573619_Chip-Seq_HEK293_Human1.00565160
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99355557
87CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97683630
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97532073
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96186207
90NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95764153
91CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95061481
92* P300_19829295_ChIP-Seq_ESCs_Human0.94192454
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92698484
94ELF5_23300383_ChIP-Seq_T47D_Human0.92670950
95SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92565943
96TP53_22573176_ChIP-Seq_HFKS_Human0.91654867
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91584529
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90569221
99GATA1_26923725_Chip-Seq_HPCs_Mouse0.88806410
100* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88254117
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87582604
102CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87428429
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87342045
104* CBX2_27304074_Chip-Seq_ESCs_Mouse0.85022671
105KDM5A_27292631_Chip-Seq_BREAST_Human0.83054993
106TRIM28_21343339_ChIP-Seq_HEK293_Human0.82047499
107MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81819345
108PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81270903
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81024438
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80937082
111* RNF2_27304074_Chip-Seq_NSC_Mouse0.80683758
112ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78860295
113PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78572056
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.78285281
115CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78201258
116MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77397036
117EZH2_27304074_Chip-Seq_ESCs_Mouse0.75066012
118POU3F2_20337985_ChIP-ChIP_501MEL_Human0.74834944
119NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.74792002
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74008063
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.73308960
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72775184
123OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71811588
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70554529

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.97985094
2MP0006276_abnormal_autonomic_nervous3.39825982
3MP0003315_abnormal_perineum_morphology2.73626702
4MP0002638_abnormal_pupillary_reflex2.72879193
5MP0001529_abnormal_vocalization2.65629798
6MP0008789_abnormal_olfactory_epithelium2.56549383
7MP0003122_maternal_imprinting2.52449557
8MP0003186_abnormal_redox_activity2.51435301
9MP0002163_abnormal_gland_morphology2.48670070
10MP0005408_hypopigmentation2.36278216
11MP0003693_abnormal_embryo_hatching2.29674375
12MP0000372_irregular_coat_pigmentation2.29653626
13MP0002751_abnormal_autonomic_nervous2.15056639
14MP0002282_abnormal_trachea_morphology2.10341974
15MP0010030_abnormal_orbit_morphology2.09914586
16MP0008058_abnormal_DNA_repair2.09678498
17MP0001188_hyperpigmentation2.09548879
18MP0002938_white_spotting2.08948743
19MP0003890_abnormal_embryonic-extraembry2.08738998
20MP0008877_abnormal_DNA_methylation1.98473155
21MP0009053_abnormal_anal_canal1.93651228
22MP0010386_abnormal_urinary_bladder1.88731853
23MP0001293_anophthalmia1.82702913
24MP0002277_abnormal_respiratory_mucosa1.80618917
25MP0003136_yellow_coat_color1.80424342
26MP0008932_abnormal_embryonic_tissue1.79297298
27MP0010094_abnormal_chromosome_stability1.77703874
28MP0009697_abnormal_copulation1.74459910
29MP0000049_abnormal_middle_ear1.72907565
30MP0005394_taste/olfaction_phenotype1.70818823
31MP0005499_abnormal_olfactory_system1.70818823
32MP0003123_paternal_imprinting1.68309835
33MP0002736_abnormal_nociception_after1.67034413
34MP0006072_abnormal_retinal_apoptosis1.66763726
35MP0001905_abnormal_dopamine_level1.63593588
36MP0005423_abnormal_somatic_nervous1.62714477
37MP0000538_abnormal_urinary_bladder1.56178668
38MP0009250_abnormal_appendicular_skeleto1.55768922
39MP0001984_abnormal_olfaction1.54742969
40MP0004782_abnormal_surfactant_physiolog1.53263298
41MP0002148_abnormal_hypersensitivity_rea1.51847428
42MP0006036_abnormal_mitochondrial_physio1.48768292
43MP0003942_abnormal_urinary_system1.46999830
44MP0004957_abnormal_blastocyst_morpholog1.46360191
45MP0008995_early_reproductive_senescence1.43776641
46MP0006035_abnormal_mitochondrial_morpho1.42294291
47MP0003724_increased_susceptibility_to1.41991978
48MP0001346_abnormal_lacrimal_gland1.37751944
49MP0001485_abnormal_pinna_reflex1.36929878
50MP0002160_abnormal_reproductive_system1.34244965
51MP0004142_abnormal_muscle_tone1.32502731
52MP0002132_abnormal_respiratory_system1.32153897
53MP0003011_delayed_dark_adaptation1.32000652
54MP0005379_endocrine/exocrine_gland_phen1.31924268
55MP0003111_abnormal_nucleus_morphology1.30101019
56MP0002102_abnormal_ear_morphology1.29706088
57MP0003121_genomic_imprinting1.28898771
58MP0001968_abnormal_touch/_nociception1.28562402
59MP0003787_abnormal_imprinting1.28253515
60MP0003806_abnormal_nucleotide_metabolis1.26337192
61MP0005084_abnormal_gallbladder_morpholo1.25820406
62MP0002735_abnormal_chemical_nociception1.25045257
63MP0002653_abnormal_ependyma_morphology1.23353147
64MP0005503_abnormal_tendon_morphology1.20884976
65MP0009046_muscle_twitch1.20826810
66MP0000778_abnormal_nervous_system1.20560279
67MP0006292_abnormal_olfactory_placode1.19870950
68MP0002234_abnormal_pharynx_morphology1.18709207
69MP0009785_altered_susceptibility_to1.18004122
70MP0002837_dystrophic_cardiac_calcinosis1.16652595
71MP0003938_abnormal_ear_development1.16337419
72MP0003718_maternal_effect1.15957691
73MP0005551_abnormal_eye_electrophysiolog1.15830370
74MP0001835_abnormal_antigen_presentation1.15578141
75MP0002697_abnormal_eye_size1.12626238
76MP0003119_abnormal_digestive_system1.10477751
77MP0005389_reproductive_system_phenotype1.09882131
78MP0003941_abnormal_skin_development1.08948813
79MP0002272_abnormal_nervous_system1.07210543
80MP0002210_abnormal_sex_determination1.06620178
81MP0001986_abnormal_taste_sensitivity1.06139164
82MP0005645_abnormal_hypothalamus_physiol1.06030644
83MP0000537_abnormal_urethra_morphology1.05186900
84MP0001919_abnormal_reproductive_system1.04698764
85MP0000566_synostosis1.01427677
86MP0003880_abnormal_central_pattern0.99563875
87MP0002177_abnormal_outer_ear0.97502033
88MP0002557_abnormal_social/conspecific_i0.96752952
89MP0009745_abnormal_behavioral_response0.96730894
90MP0003283_abnormal_digestive_organ0.95926624
91MP0003786_premature_aging0.94904520
92MP0005253_abnormal_eye_physiology0.94321178
93MP0005187_abnormal_penis_morphology0.93463444
94MP0000858_altered_metastatic_potential0.93320019
95MP0003436_decreased_susceptibility_to0.93285162
96MP0002876_abnormal_thyroid_physiology0.93236182
97MP0002332_abnormal_exercise_endurance0.92459685
98MP0005646_abnormal_pituitary_gland0.92101625
99MP0002734_abnormal_mechanical_nocicepti0.91460076
100MP0005197_abnormal_uvea_morphology0.91095554
101MP0004742_abnormal_vestibular_system0.90032122
102MP0000955_abnormal_spinal_cord0.88155868
103MP0002752_abnormal_somatic_nervous0.88080235
104MP0005195_abnormal_posterior_eye0.87603185
105MP0003861_abnormal_nervous_system0.84995490
106MP0000647_abnormal_sebaceous_gland0.84685778
107MP0002233_abnormal_nose_morphology0.84486417
108MP0005367_renal/urinary_system_phenotyp0.82712914
109MP0000516_abnormal_urinary_system0.82712914
110MP0004883_abnormal_blood_vessel0.82539619
111MP0008007_abnormal_cellular_replicative0.82450364
112MP0001286_abnormal_eye_development0.81912268
113MP0001145_abnormal_male_reproductive0.81890901
114MP0001929_abnormal_gametogenesis0.81260553
115MP0003385_abnormal_body_wall0.81214187
116MP0000653_abnormal_sex_gland0.80567860
117MP0003195_calcinosis0.79752918
118MP0003567_abnormal_fetal_cardiomyocyte0.79326971
119MP0005636_abnormal_mineral_homeostasis0.78167455
120MP0005391_vision/eye_phenotype0.78153295
121MP0000681_abnormal_thyroid_gland0.77466884
122MP0002090_abnormal_vision0.76803761
123MP0004272_abnormal_basement_membrane0.76233762
124MP0001879_abnormal_lymphatic_vessel0.75256191
125MP0003077_abnormal_cell_cycle0.75182400
126MP0001542_abnormal_bone_strength0.74716635
127MP0005174_abnormal_tail_pigmentation0.72374985
128MP0001727_abnormal_embryo_implantation0.70408967
129MP0000358_abnormal_cell_content/0.70163435
130MP0000762_abnormal_tongue_morphology0.69033382
131MP0002249_abnormal_larynx_morphology0.68114286
132MP0005248_abnormal_Harderian_gland0.66068743
133MP0005164_abnormal_response_to0.64665817
134MP0003937_abnormal_limbs/digits/tail_de0.62669488
135MP0001340_abnormal_eyelid_morphology0.61654740
136MP0004133_heterotaxia0.61369836
137MP0000163_abnormal_cartilage_morphology0.61170371
138MP0004381_abnormal_hair_follicle0.59779559
139MP0001853_heart_inflammation0.58782572
140MP0002184_abnormal_innervation0.58675785
141MP0000613_abnormal_salivary_gland0.56928987
142MP0000026_abnormal_inner_ear0.56757254
143MP0000631_abnormal_neuroendocrine_gland0.56388066
144MP0005171_absent_coat_pigmentation0.56074857
145MP0008875_abnormal_xenobiotic_pharmacok0.56041015

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.63120392
2Abnormal mitochondria in muscle tissue (HP:0008316)5.98718067
3Mitochondrial inheritance (HP:0001427)5.78096848
4Progressive macrocephaly (HP:0004481)5.68501425
5Abnormality of cells of the erythroid lineage (HP:0012130)5.37921469
6Increased hepatocellular lipid droplets (HP:0006565)5.29987323
7Acute encephalopathy (HP:0006846)5.28982502
8Increased CSF lactate (HP:0002490)4.79274457
9Lipid accumulation in hepatocytes (HP:0006561)4.66817638
10Abnormal number of erythroid precursors (HP:0012131)4.60013490
11Reticulocytopenia (HP:0001896)4.53978351
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.48063127
13Hepatocellular necrosis (HP:0001404)4.38862559
14Decreased activity of mitochondrial respiratory chain (HP:0008972)4.31469084
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.31469084
16Renal Fanconi syndrome (HP:0001994)4.30663515
17Exertional dyspnea (HP:0002875)3.95836065
18Hepatic necrosis (HP:0002605)3.95460349
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.94964338
20Exercise intolerance (HP:0003546)3.73214909
21Increased intramyocellular lipid droplets (HP:0012240)3.71776882
223-Methylglutaconic aciduria (HP:0003535)3.67045945
23Hypothermia (HP:0002045)3.66606753
24Pallor (HP:0000980)3.65201318
25Cerebral edema (HP:0002181)3.60669035
26Macrocytic anemia (HP:0001972)3.56466349
27Optic disc pallor (HP:0000543)3.32820295
28Abnormal hemoglobin (HP:0011902)3.32770272
29Respiratory failure (HP:0002878)3.21847918
30Lactic acidosis (HP:0003128)3.11966582
31Respiratory difficulties (HP:0002880)3.06209381
32Increased muscle lipid content (HP:0009058)3.02336910
33Increased serum lactate (HP:0002151)2.97455913
34Septo-optic dysplasia (HP:0100842)2.88162837
35Abnormality of renal resorption (HP:0011038)2.83936276
36Hyperphosphaturia (HP:0003109)2.79139976
37Abnormality of glycolysis (HP:0004366)2.70903533
38Increased serum pyruvate (HP:0003542)2.70903533
39Colon cancer (HP:0003003)2.60256342
40Leukodystrophy (HP:0002415)2.54394905
41Abnormality of urine glucose concentration (HP:0011016)2.53975420
42Glycosuria (HP:0003076)2.53975420
43Aplastic anemia (HP:0001915)2.53655312
44Conjunctival hamartoma (HP:0100780)2.53062295
45Abnormality of the labia minora (HP:0012880)2.49227716
46Hyperglycinemia (HP:0002154)2.42681959
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.31990252
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30662228
49Increased IgM level (HP:0003496)2.26163224
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25887736
51Abnormality of alanine metabolism (HP:0010916)2.25887736
52Hyperalaninemia (HP:0003348)2.25887736
53Myokymia (HP:0002411)2.25260821
54Molar tooth sign on MRI (HP:0002419)2.22734683
55Abnormality of midbrain morphology (HP:0002418)2.22734683
56Methylmalonic acidemia (HP:0002912)2.22437550
57Renal tubular dysfunction (HP:0000124)2.20908236
58Neuroendocrine neoplasm (HP:0100634)2.18268795
59Abnormal urine phosphate concentration (HP:0012599)2.15831092
60Congenital, generalized hypertrichosis (HP:0004540)2.15493781
61X-linked dominant inheritance (HP:0001423)2.12888844
62Absent septum pellucidum (HP:0001331)2.11635278
63Stenosis of the external auditory canal (HP:0000402)2.09111612
64Medial flaring of the eyebrow (HP:0010747)2.08466557
65Amniotic constriction ring (HP:0009775)2.05511781
66Abnormality of placental membranes (HP:0011409)2.05511781
67Microvesicular hepatic steatosis (HP:0001414)1.99348670
68True hermaphroditism (HP:0010459)1.95405228
69Abnormal hair whorl (HP:0010721)1.93369299
70Abnormality of serum amino acid levels (HP:0003112)1.92690458
71Degeneration of anterior horn cells (HP:0002398)1.91614591
72Abnormality of the anterior horn cell (HP:0006802)1.91614591
73Limb dystonia (HP:0002451)1.90979184
74Meckel diverticulum (HP:0002245)1.86705856
75Palpitations (HP:0001962)1.85177323
76Methylmalonic aciduria (HP:0012120)1.84913169
77Anophthalmia (HP:0000528)1.82660714
78Type I transferrin isoform profile (HP:0003642)1.82439070
79Nephronophthisis (HP:0000090)1.80858431
80Supernumerary spleens (HP:0009799)1.80201863
81Pheochromocytoma (HP:0002666)1.79911331
82Abnormal lung lobation (HP:0002101)1.79658989
83Parakeratosis (HP:0001036)1.79330879
84Metaphyseal dysplasia (HP:0100255)1.78850720
85Abnormality of the ileum (HP:0001549)1.78322168
86Congenital primary aphakia (HP:0007707)1.76947853
87Abnormality of the septum pellucidum (HP:0007375)1.76857973
88Abnormal pupillary function (HP:0007686)1.76835786
89Absent thumb (HP:0009777)1.76763937
90Nephrogenic diabetes insipidus (HP:0009806)1.76153490
91Intestinal atresia (HP:0011100)1.75967122
92Abnormality of methionine metabolism (HP:0010901)1.75662008
93Depressed nasal ridge (HP:0000457)1.75606182
94Cerebral hypomyelination (HP:0006808)1.75316637
95Pendular nystagmus (HP:0012043)1.74572885
96Maternal diabetes (HP:0009800)1.74045400
97Bifid tongue (HP:0010297)1.72563777
98Neoplasm of head and neck (HP:0012288)1.72493105
99Esophageal neoplasm (HP:0100751)1.72493105
10011 pairs of ribs (HP:0000878)1.71952985
101Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71610141
102Bilateral microphthalmos (HP:0007633)1.70623740
103Gait imbalance (HP:0002141)1.69880804
104Megaloblastic anemia (HP:0001889)1.67960665
105Optic nerve hypoplasia (HP:0000609)1.67492419
106Neoplasm of the adrenal gland (HP:0100631)1.67245388
107Anencephaly (HP:0002323)1.67095517
108Sensory axonal neuropathy (HP:0003390)1.66427770
109Nausea (HP:0002018)1.65655928
110Multiple enchondromatosis (HP:0005701)1.64960282
111Aplasia/Hypoplasia of the uvula (HP:0010293)1.63285218
112Horseshoe kidney (HP:0000085)1.63034228
113Rib fusion (HP:0000902)1.62247020
114Lethargy (HP:0001254)1.62078015
115Pancreatic cysts (HP:0001737)1.61662170
116Aplasia/hypoplasia of the uterus (HP:0008684)1.61164345
117Hyperglycinuria (HP:0003108)1.61076060
118Oral leukoplakia (HP:0002745)1.60536696
119Male pseudohermaphroditism (HP:0000037)1.60004946
120Cleft eyelid (HP:0000625)1.59650738
121Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.57236930
122Congenital ichthyosiform erythroderma (HP:0007431)1.57131072
123Abnormality of the axillary hair (HP:0100134)1.56382867
124Abnormality of secondary sexual hair (HP:0009888)1.56382867
125Pancreatic fibrosis (HP:0100732)1.56016574
126Redundant skin (HP:0001582)1.54509603
127CNS demyelination (HP:0007305)1.53486514
128Poor head control (HP:0002421)1.52208349
129Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.52025576
130Abnormality of the phalanges of the 5th finger (HP:0004213)1.50264345
131Abnormality of the lacrimal duct (HP:0011481)1.49432258
132Vaginal atresia (HP:0000148)1.48937406
133Concave nail (HP:0001598)1.47231006
134Genital tract atresia (HP:0001827)1.47121020
135Microretrognathia (HP:0000308)1.46002693
136Triphalangeal thumb (HP:0001199)1.45836798
137Emotional lability (HP:0000712)1.45222739
138Abnormality of the nasolacrimal system (HP:0000614)1.44551948
139Sclerocornea (HP:0000647)1.44309817
140Aplasia cutis congenita (HP:0001057)1.43526658
141Poor suck (HP:0002033)1.42829408

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.28173594
2MAP3K123.79787741
3VRK23.38208912
4TLK13.05841406
5CDC72.73056222
6LIMK12.70460917
7PBK2.67505427
8PIM22.48349510
9NME12.47562235
10TESK12.43798936
11MST42.35305130
12EIF2AK12.34486868
13NEK12.30554872
14PDK22.29036993
15VRK12.28272300
16BMPR1B2.24815812
17TNIK2.12150530
18SRPK12.11356207
19WNK32.03020634
20EPHB22.01799030
21CDK81.99389612
22TRIM281.95973082
23MYLK1.91538905
24ERBB31.84604914
25BUB11.80381023
26ARAF1.79619261
27TTK1.69620439
28GRK51.65698568
29STK161.63471050
30GRK71.53424551
31EIF2AK31.50298484
32DYRK21.40572493
33TGFBR11.37855395
34STK38L1.31320758
35ILK1.30078263
36BMPR21.29065051
37STK391.27886437
38CASK1.26939361
39NEK91.25248505
40SIK31.24148951
41MKNK11.24024374
42ABL21.23234901
43ZAK1.22428949
44ADRBK21.20991287
45MAP4K21.20331018
46WEE11.14343367
47CDK191.11975653
48BRAF1.11773351
49MAP2K71.08985544
50PRKCG1.06346961
51MAP3K111.05826407
52OXSR11.04390017
53CSNK1G21.03497618
54GRK11.03299088
55PASK1.01748752
56STK241.01167313
57CSNK1G11.00353413
58MARK11.00341234
59CHEK20.99788523
60NEK20.99784493
61MAP3K40.99699304
62BRSK20.98923004
63PLK20.97484745
64PINK10.97402675
65TAF10.97271435
66BCR0.95376292
67PLK40.93799562
68EIF2AK20.93156012
69ADRBK10.92477193
70IRAK40.91990430
71PLK30.90227685
72RPS6KB20.89257839
73MKNK20.88547884
74ACVR1B0.85026927
75MAP3K90.84894366
76YES10.83440969
77BCKDK0.83288373
78MUSK0.80139163
79MAPK130.79851654
80FRK0.78141023
81AURKA0.77196465
82CSNK1E0.76813513
83RPS6KA40.75387413
84CSNK2A10.74379269
85ATR0.70885726
86TXK0.70852301
87BLK0.70170075
88MAP3K140.67628860
89LRRK20.65736184
90IRAK10.65672718
91CSNK1A1L0.61044493
92MST1R0.60446795
93STK30.60077355
94WNK40.59961154
95INSRR0.59753204
96DYRK30.59001642
97TEC0.58907303
98DAPK30.58693777
99CSNK2A20.57558946
100RPS6KA50.57251974
101TESK20.54044676
102AURKB0.53938905
103CDK30.53389907
104TSSK60.51999195
105BRSK10.51084960
106PRKCI0.49618737
107KDR0.49412044
108EPHA40.49353787
109NTRK20.48897229
110PHKG10.48200476
111PHKG20.48200476
112CHEK10.47253015
113ATM0.46545197
114MOS0.45482142
115MINK10.44787645
116LATS20.44459454
117CCNB10.44410111
118ALK0.44335041
119PTK2B0.43883117
120STK40.43604750
121CSNK1A10.43182071
122CDK140.42383139
123PKN10.42102312
124MAPKAPK50.40933314
125OBSCN0.40654926
126IRAK30.40101747
127CAMKK20.39990387
128UHMK10.39978761
129CDK180.39800255
130PLK10.39719427
131CDK11A0.39701817
132CAMK2A0.39129221
133TAOK30.38929316
134IKBKB0.38639942
135MAP2K20.36883813
136MAP2K10.36242697
137PNCK0.33419207
138SYK0.32370294
139PRKCD0.32090955
140PIM10.31753284
141CSNK1G30.30396247
142PAK40.30205069
143NUAK10.30027249
144TBK10.29964213
145PRKG20.29519069
146CDK70.28975427
147ERBB40.26024856
148TAOK20.25186127
149PRKCE0.24957714
150MAP3K50.24288959

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.31143558
2Oxidative phosphorylation_Homo sapiens_hsa001905.57010848
3Parkinsons disease_Homo sapiens_hsa050124.96659457
4Proteasome_Homo sapiens_hsa030504.41587847
5Huntingtons disease_Homo sapiens_hsa050163.70282889
6Alzheimers disease_Homo sapiens_hsa050103.50840406
7Protein export_Homo sapiens_hsa030603.18613778
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.16474375
9RNA polymerase_Homo sapiens_hsa030202.63399153
10Cardiac muscle contraction_Homo sapiens_hsa042601.96656943
11Pyrimidine metabolism_Homo sapiens_hsa002401.82679692
12Spliceosome_Homo sapiens_hsa030401.65182886
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48378128
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38649022
15Nucleotide excision repair_Homo sapiens_hsa034201.37079136
16DNA replication_Homo sapiens_hsa030301.33003526
17Collecting duct acid secretion_Homo sapiens_hsa049661.29256488
18Propanoate metabolism_Homo sapiens_hsa006401.28433344
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25810352
20Sulfur metabolism_Homo sapiens_hsa009201.24496710
21Homologous recombination_Homo sapiens_hsa034401.24409598
22Mismatch repair_Homo sapiens_hsa034301.23574340
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.23350012
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18629008
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16131326
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12624830
27Steroid biosynthesis_Homo sapiens_hsa001001.11220353
28RNA degradation_Homo sapiens_hsa030181.06509032
29Basal transcription factors_Homo sapiens_hsa030221.06120354
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04220666
31Vibrio cholerae infection_Homo sapiens_hsa051101.03606460
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99804653
33RNA transport_Homo sapiens_hsa030130.96221901
34Fatty acid elongation_Homo sapiens_hsa000620.95764053
35Graft-versus-host disease_Homo sapiens_hsa053320.94193516
36Rheumatoid arthritis_Homo sapiens_hsa053230.93823304
37Nicotine addiction_Homo sapiens_hsa050330.92297225
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91965365
39Selenocompound metabolism_Homo sapiens_hsa004500.91927891
40Allograft rejection_Homo sapiens_hsa053300.91684121
41Maturity onset diabetes of the young_Homo sapiens_hsa049500.91138843
42Butanoate metabolism_Homo sapiens_hsa006500.90512308
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88124277
44Tyrosine metabolism_Homo sapiens_hsa003500.88093697
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84832542
46Phototransduction_Homo sapiens_hsa047440.81141938
47Phenylalanine metabolism_Homo sapiens_hsa003600.80914088
48Purine metabolism_Homo sapiens_hsa002300.80617149
49Phagosome_Homo sapiens_hsa041450.77090336
50Glutathione metabolism_Homo sapiens_hsa004800.76976682
51Legionellosis_Homo sapiens_hsa051340.72983435
52Vitamin B6 metabolism_Homo sapiens_hsa007500.70418090
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70045641
54Asthma_Homo sapiens_hsa053100.68595401
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67763569
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67465807
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63938816
58Epstein-Barr virus infection_Homo sapiens_hsa051690.62568062
59Chemical carcinogenesis_Homo sapiens_hsa052040.62188884
60Base excision repair_Homo sapiens_hsa034100.61747345
61Tryptophan metabolism_Homo sapiens_hsa003800.61623211
62Metabolic pathways_Homo sapiens_hsa011000.58063441
63beta-Alanine metabolism_Homo sapiens_hsa004100.56308400
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56135936
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55395004
66Caffeine metabolism_Homo sapiens_hsa002320.54760678
67Autoimmune thyroid disease_Homo sapiens_hsa053200.53691387
68Cell cycle_Homo sapiens_hsa041100.53538726
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53261037
70Sulfur relay system_Homo sapiens_hsa041220.53243658
71p53 signaling pathway_Homo sapiens_hsa041150.52925927
72Carbon metabolism_Homo sapiens_hsa012000.52824409
73Arachidonic acid metabolism_Homo sapiens_hsa005900.52578364
74Oocyte meiosis_Homo sapiens_hsa041140.52183516
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.49814884
76Folate biosynthesis_Homo sapiens_hsa007900.49781551
77Nitrogen metabolism_Homo sapiens_hsa009100.48621177
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47894605
79Arginine and proline metabolism_Homo sapiens_hsa003300.47702542
80Fanconi anemia pathway_Homo sapiens_hsa034600.47135421
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46501786
82Non-homologous end-joining_Homo sapiens_hsa034500.45882069
83One carbon pool by folate_Homo sapiens_hsa006700.44729949
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44308783
85Systemic lupus erythematosus_Homo sapiens_hsa053220.43995113
86Basal cell carcinoma_Homo sapiens_hsa052170.43496141
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43309222
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42496807
89Pertussis_Homo sapiens_hsa051330.42487485
90Type I diabetes mellitus_Homo sapiens_hsa049400.42408683
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41895649
92Biosynthesis of amino acids_Homo sapiens_hsa012300.41403502
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.40836072
94Hedgehog signaling pathway_Homo sapiens_hsa043400.40347724
95Thyroid cancer_Homo sapiens_hsa052160.40093754
96Galactose metabolism_Homo sapiens_hsa000520.38701855
97Fatty acid degradation_Homo sapiens_hsa000710.38457879
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37840434
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37428065
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37130804
101Fatty acid metabolism_Homo sapiens_hsa012120.37007979
102Fat digestion and absorption_Homo sapiens_hsa049750.36190215
103Vitamin digestion and absorption_Homo sapiens_hsa049770.36095067
104Pyruvate metabolism_Homo sapiens_hsa006200.34181674
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33661154
106GABAergic synapse_Homo sapiens_hsa047270.32832345
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.32351168
108Antigen processing and presentation_Homo sapiens_hsa046120.32002035
109Synaptic vesicle cycle_Homo sapiens_hsa047210.30792399
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29744713
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28198518
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27935886
113Hippo signaling pathway_Homo sapiens_hsa043900.27021620
114Linoleic acid metabolism_Homo sapiens_hsa005910.26765777
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25484640
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24428354
117Alcoholism_Homo sapiens_hsa050340.24313678
118TGF-beta signaling pathway_Homo sapiens_hsa043500.23772877
119Wnt signaling pathway_Homo sapiens_hsa043100.23439316
120Taste transduction_Homo sapiens_hsa047420.23137372
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.22066364
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21738870
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20661745
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.19589466
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19487897
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18718053
127Salmonella infection_Homo sapiens_hsa051320.18642954
128Hematopoietic cell lineage_Homo sapiens_hsa046400.18551230
129Melanoma_Homo sapiens_hsa052180.18070492
130Serotonergic synapse_Homo sapiens_hsa047260.18066114
131Malaria_Homo sapiens_hsa051440.17116137
132African trypanosomiasis_Homo sapiens_hsa051430.17034799
133N-Glycan biosynthesis_Homo sapiens_hsa005100.15883025
134Leishmaniasis_Homo sapiens_hsa051400.15606889
135mRNA surveillance pathway_Homo sapiens_hsa030150.15481652
136Peroxisome_Homo sapiens_hsa041460.14236723
137Retinol metabolism_Homo sapiens_hsa008300.14101279
138Herpes simplex infection_Homo sapiens_hsa051680.13923363
139Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.13453987
140Apoptosis_Homo sapiens_hsa042100.11534940
141Bladder cancer_Homo sapiens_hsa052190.10722252
142Shigellosis_Homo sapiens_hsa051310.08709930
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08114330

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