ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tachykinin receptor signaling pathway (GO:0007217)	9.49719240
2	positive regulation of action potential (GO:0045760)	9.07808030
3	protein-chromophore linkage (GO:0018298)	7.04198499
4	negative regulation of heart rate (GO:0010459)	6.85375542
5	positive regulation of digestive system process (GO:0060456)	6.75946106
6	positive regulation of synaptic transmission, GABAergic (GO:0032230)	6.23179161
7	cullin deneddylation (GO:0010388)	6.13817958
8	regulation of glucocorticoid secretion (GO:2000849)	6.07204515
9	regulation of action potential (GO:0098900)	5.81442146
10	inositol phosphate catabolic process (GO:0071545)	5.76176631
11	inositol phosphate dephosphorylation (GO:0046855)	5.72014645
12	phosphorylated carbohydrate dephosphorylation (GO:0046838)	5.72014645
13	positive regulation of steroid hormone secretion (GO:2000833)	5.71590945
14	platelet dense granule organization (GO:0060155)	5.64060312
15	protein deneddylation (GO:0000338)	5.63467480
16	regulation of vesicle fusion (GO:0031338)	5.19078377
17	response to pheromone (GO:0019236)	5.16085074
18	proline transport (GO:0015824)	5.00616841
19	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	4.86208225
20	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	4.86208225
21	regulation of corticosteroid hormone secretion (GO:2000846)	4.84219244
22	establishment of protein localization to Golgi (GO:0072600)	4.73981437
23	protein targeting to Golgi (GO:0000042)	4.71913166
24	presynaptic membrane assembly (GO:0097105)	4.42322972
25	polyol catabolic process (GO:0046174)	4.26302127
26	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.24266383
27	response to misfolded protein (GO:0051788)	4.18649301
28	positive regulation of renal sodium excretion (GO:0035815)	4.14978224
29	behavioral response to nicotine (GO:0035095)	4.11773013
30	vitamin transmembrane transport (GO:0035461)	4.05550853
31	early endosome to late endosome transport (GO:0045022)	3.98773534
32	microtubule nucleation (GO:0007020)	3.96656828
33	artery development (GO:0060840)	3.92438854
34	presynaptic membrane organization (GO:0097090)	3.87921542
35	DNA replication-dependent nucleosome assembly (GO:0006335)	3.84384386
36	DNA replication-dependent nucleosome organization (GO:0034723)	3.84384386
37	protein localization to Golgi apparatus (GO:0034067)	3.79181158
38	alanine transport (GO:0032328)	3.78776822
39	inositol metabolic process (GO:0006020)	3.76955862
40	transepithelial transport (GO:0070633)	3.72142348
41	righting reflex (GO:0060013)	3.71604900
42	photoreceptor cell maintenance (GO:0045494)	3.67904573
43	L-ascorbic acid metabolic process (GO:0019852)	3.66970181
44	positive regulation of mitochondrial membrane permeability (GO:0035794)	3.51402200
45	postreplication repair (GO:0006301)	3.43116871
46	anterograde synaptic vesicle transport (GO:0048490)	3.33507291
47	regulation of steroid hormone secretion (GO:2000831)	3.31164459
48	auditory behavior (GO:0031223)	3.30478469
49	glycosphingolipid biosynthetic process (GO:0006688)	3.28221371
50	pyrimidine nucleobase catabolic process (GO:0006208)	3.25645311
51	somite development (GO:0061053)	3.23001005
52	rhodopsin mediated signaling pathway (GO:0016056)	3.20346003
53	peptidyl-threonine dephosphorylation (GO:0035970)	3.17120215
54	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.09807055
55	negative regulation of cAMP-mediated signaling (GO:0043951)	3.08224645
56	neuron cell-cell adhesion (GO:0007158)	3.04598140
57	UTP metabolic process (GO:0046051)	3.01021435
58	cAMP catabolic process (GO:0006198)	3.00002639
59	negative regulation of heart contraction (GO:0045822)	2.99560026
60	axonal fasciculation (GO:0007413)	2.99451886
61	establishment of mitochondrion localization (GO:0051654)	2.87400282
62	limb bud formation (GO:0060174)	2.86700378
63	mechanosensory behavior (GO:0007638)	2.86588981
64	protein-cofactor linkage (GO:0018065)	2.86001415
65	postsynaptic membrane organization (GO:0001941)	2.84034089
66	regulation of sequestering of triglyceride (GO:0010889)	2.83828641
67	inner ear receptor stereocilium organization (GO:0060122)	2.80962939
68	axoneme assembly (GO:0035082)	2.78912046
69	negative regulation of exocytosis (GO:0045920)	2.75753778
70	secretory granule organization (GO:0033363)	2.75640278
71	histone H2A ubiquitination (GO:0033522)	2.73773597
72	regulation of renal sodium excretion (GO:0035813)	2.73746710
73	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.73225679
74	regulation of synaptic transmission, GABAergic (GO:0032228)	2.71738446
75	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.69069477
76	galactose catabolic process (GO:0019388)	2.68993256
77	retinal cone cell development (GO:0046549)	2.68529667
78	positive regulation of vesicle fusion (GO:0031340)	2.65426771
79	cellular response to sterol (GO:0036315)	2.65160874
80	nucleobase catabolic process (GO:0046113)	2.64017858
81	water-soluble vitamin biosynthetic process (GO:0042364)	2.62958364
82	ribonucleoprotein complex disassembly (GO:0032988)	2.60853709
83	anterograde axon cargo transport (GO:0008089)	2.60002184
84	regulation of protein kinase A signaling (GO:0010738)	2.59322547
85	behavioral response to ethanol (GO:0048149)	2.59104078
86	vocalization behavior (GO:0071625)	2.58820558
87	retinol metabolic process (GO:0042572)	2.58644145
88	long-term memory (GO:0007616)	2.57766080
89	neuronal action potential propagation (GO:0019227)	2.57747475
90	protein polyglutamylation (GO:0018095)	2.56330340
91	regulation of digestive system process (GO:0044058)	2.55821580
92	neuronal ion channel clustering (GO:0045161)	2.55255228
93	negative regulation of blood circulation (GO:1903523)	2.54615447
94	auditory receptor cell stereocilium organization (GO:0060088)	2.53573673
95	cyclic nucleotide catabolic process (GO:0009214)	2.52732945
96	nephron epithelium morphogenesis (GO:0072088)	2.51737938
97	nephron tubule morphogenesis (GO:0072078)	2.51737938
98	protein K11-linked deubiquitination (GO:0035871)	2.51265792
99	response to auditory stimulus (GO:0010996)	2.51118744
100	regulation of Rac protein signal transduction (GO:0035020)	2.51014494

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.91572304
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.68207261
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.46886756
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.45434875
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	3.43965650
6	FUS_26573619_Chip-Seq_HEK293_Human	3.42102117
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.00703399
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.87026801
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.61487208
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.54533453
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.42862718
12	P300_19829295_ChIP-Seq_ESCs_Human	2.31915928
13	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.28622739
14	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.26866928
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.25157442
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.10267388
17	EWS_26573619_Chip-Seq_HEK293_Human	2.10058702
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06902597
19	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.99381586
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.87144444
21	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.81561455
22	AR_21572438_ChIP-Seq_LNCaP_Human	1.81254650
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.80546878
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.78357132
25	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.71145380
26	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.63725003
27	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.63388987
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.62984486
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.60915213
30	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.59854833
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.59620182
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.59553041
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.55195406
34	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.54222003
35	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.54108070
36	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.52917177
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.52777375
38	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.52084245
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49304779
40	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.48814311
41	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.46673992
42	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.46524317
43	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.45743707
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.44576096
45	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44508186
46	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.42893237
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42737530
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39362895
49	AR_25329375_ChIP-Seq_VCAP_Human	1.39281789
50	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39238876
51	STAT3_23295773_ChIP-Seq_U87_Human	1.39203963
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39160195
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39160195
54	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.38682660
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.37426377
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.37191555
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37135749
58	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37135749
59	BCAT_22108803_ChIP-Seq_LS180_Human	1.35901399
60	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.32993002
61	REST_21632747_ChIP-Seq_MESCs_Mouse	1.31586866
62	TCF4_23295773_ChIP-Seq_U87_Human	1.30048133
63	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.29658912
64	P53_22387025_ChIP-Seq_ESCs_Mouse	1.28279697
65	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.27298492
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27057320
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.26561490
68	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.25090838
69	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24509855
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.24296046
71	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.24274800
72	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.22911897
73	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.21758660
74	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.21278668
75	AHR_22903824_ChIP-Seq_MCF-7_Human	1.21192748
76	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.19822025
77	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.19557711
78	JUN_21703547_ChIP-Seq_K562_Human	1.19036253
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17264495
80	TCF4_22108803_ChIP-Seq_LS180_Human	1.16918381
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.16909068
82	TP53_22573176_ChIP-Seq_HFKS_Human	1.16067613
83	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.15421300
84	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.15058777
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14549335
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14014415
87	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.13430330
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.12791939
89	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.11111119
90	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.10791734
91	P300_18555785_Chip-Seq_ESCs_Mouse	1.10472948
92	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.09795118
93	AR_20517297_ChIP-Seq_VCAP_Human	1.08736491
94	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.08539371
95	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.08323716
96	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.08172228
97	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.05783114
98	ELK1_19687146_ChIP-ChIP_HELA_Human	1.05221806
99	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.04757115
100	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04664663

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	7.23909516
2	MP0010386_abnormal_urinary_bladder	6.83320983
3	MP0005083_abnormal_biliary_tract	5.47401974
4	MP0002638_abnormal_pupillary_reflex	5.32085148
5	MP0005084_abnormal_gallbladder_morpholo	4.14099308
6	MP0005085_abnormal_gallbladder_physiolo	3.26351996
7	MP0006072_abnormal_retinal_apoptosis	2.94945805
8	MP0005253_abnormal_eye_physiology	2.66066560
9	MP0005365_abnormal_bile_salt	2.23644755
10	MP0001529_abnormal_vocalization	2.15623986
11	MP0002736_abnormal_nociception_after	2.02000416
12	MP0001764_abnormal_homeostasis	2.01150999
13	MP0002928_abnormal_bile_duct	1.93946272
14	MP0005551_abnormal_eye_electrophysiolog	1.81350194
15	MP0003122_maternal_imprinting	1.78923625
16	MP0004859_abnormal_synaptic_plasticity	1.76109769
17	MP0001968_abnormal_touch/_nociception	1.71581554
18	MP0003195_calcinosis	1.69671258
19	MP0002160_abnormal_reproductive_system	1.66810761
20	MP0002102_abnormal_ear_morphology	1.58958408
21	MP0003121_genomic_imprinting	1.58353448
22	MP0003880_abnormal_central_pattern	1.52312337
23	MP0002572_abnormal_emotion/affect_behav	1.50434793
24	MP0002909_abnormal_adrenal_gland	1.48540253
25	MP0001486_abnormal_startle_reflex	1.44147647
26	MP0001502_abnormal_circadian_rhythm	1.41996552
27	MP0002272_abnormal_nervous_system	1.41017720
28	MP0005187_abnormal_penis_morphology	1.38381479
29	MP0000778_abnormal_nervous_system	1.35574896
30	MP0002184_abnormal_innervation	1.35053421
31	MP0008877_abnormal_DNA_methylation	1.34944725
32	MP0000538_abnormal_urinary_bladder	1.34675441
33	MP0005379_endocrine/exocrine_gland_phen	1.34632348
34	MP0002234_abnormal_pharynx_morphology	1.33665694
35	MP0009046_muscle_twitch	1.32707162
36	MP0009745_abnormal_behavioral_response	1.31747413
37	MP0004142_abnormal_muscle_tone	1.31331652
38	MP0002138_abnormal_hepatobiliary_system	1.31099720
39	MP0001905_abnormal_dopamine_level	1.23371552
40	MP0002064_seizures	1.22471007
41	MP0003787_abnormal_imprinting	1.22333920
42	MP0005646_abnormal_pituitary_gland	1.20972430
43	MP0001970_abnormal_pain_threshold	1.19915350
44	MP0000427_abnormal_hair_cycle	1.18711990
45	MP0003879_abnormal_hair_cell	1.18210788
46	MP0003635_abnormal_synaptic_transmissio	1.18065898
47	MP0006276_abnormal_autonomic_nervous	1.17081480
48	MP0004270_analgesia	1.14082727
49	MP0002063_abnormal_learning/memory/cond	1.11359167
50	MP0005391_vision/eye_phenotype	1.08782721
51	MP0001984_abnormal_olfaction	1.08354027
52	MP0005195_abnormal_posterior_eye	1.08219358
53	MP0000639_abnormal_adrenal_gland	1.05380908
54	MP0005389_reproductive_system_phenotype	1.03351842
55	MP0002752_abnormal_somatic_nervous	1.02510536
56	MP0000647_abnormal_sebaceous_gland	1.00772979
57	MP0003943_abnormal_hepatobiliary_system	1.00308783
58	MP0002735_abnormal_chemical_nociception	0.97498657
59	MP0002734_abnormal_mechanical_nocicepti	0.95730950
60	MP0001919_abnormal_reproductive_system	0.93776076
61	MP0002751_abnormal_autonomic_nervous	0.91506658
62	MP0003183_abnormal_peptide_metabolism	0.90377051
63	MP0003136_yellow_coat_color	0.89878282
64	MP0000631_abnormal_neuroendocrine_gland	0.82904950
65	MP0003567_abnormal_fetal_cardiomyocyte	0.82793948
66	MP0000566_synostosis	0.82600303
67	MP0002733_abnormal_thermal_nociception	0.81596943
68	MP0001501_abnormal_sleep_pattern	0.79441945
69	MP0004043_abnormal_pH_regulation	0.79311325
70	MP0004133_heterotaxia	0.77821798
71	MP0003283_abnormal_digestive_organ	0.77355280
72	MP0002882_abnormal_neuron_morphology	0.76224826
73	MP0008775_abnormal_heart_ventricle	0.75000780
74	MP0001440_abnormal_grooming_behavior	0.74826362
75	MP0002557_abnormal_social/conspecific_i	0.74062681
76	MP0009780_abnormal_chondrocyte_physiolo	0.72339205
77	MP0004742_abnormal_vestibular_system	0.71576564
78	MP0002067_abnormal_sensory_capabilities	0.70466485
79	MP0005647_abnormal_sex_gland	0.69977217
80	MP0004924_abnormal_behavior	0.66341438
81	MP0005386_behavior/neurological_phenoty	0.66341438
82	MP0004885_abnormal_endolymph	0.65771861
83	MP0003221_abnormal_cardiomyocyte_apopto	0.65509094
84	MP0002282_abnormal_trachea_morphology	0.64492684
85	MP0003252_abnormal_bile_duct	0.64003732
86	MP0008872_abnormal_physiological_respon	0.63374192
87	MP0000230_abnormal_systemic_arterial	0.63169462
88	MP0004019_abnormal_vitamin_homeostasis	0.62064193
89	MP0002229_neurodegeneration	0.61992068
90	MP0003119_abnormal_digestive_system	0.61943729
91	MP0001756_abnormal_urination	0.61293642
92	MP0008875_abnormal_xenobiotic_pharmacok	0.60580221
93	MP0000955_abnormal_spinal_cord	0.59705422
94	MP0004147_increased_porphyrin_level	0.58723319
95	MP0005595_abnormal_vascular_smooth	0.58261598
96	MP0008057_abnormal_DNA_replication	0.57365858
97	MP0009379_abnormal_foot_pigmentation	0.57007009
98	MP0000026_abnormal_inner_ear	0.55717965
99	MP0001986_abnormal_taste_sensitivity	0.55575266
100	MP0003937_abnormal_limbs/digits/tail_de	0.54849921

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	4.25098518
2	Aplasia/Hypoplasia of the tibia (HP:0005772)	4.17285246
3	Short tibia (HP:0005736)	3.88212605
4	Abnormal hair whorl (HP:0010721)	3.77849838
5	Increased density of long bones (HP:0006392)	3.65500513
6	Amyotrophic lateral sclerosis (HP:0007354)	3.53487187
7	Volvulus (HP:0002580)	3.31413594
8	Abnormality of midbrain morphology (HP:0002418)	3.28844583
9	Molar tooth sign on MRI (HP:0002419)	3.28844583
10	Stomach cancer (HP:0012126)	3.17206179
11	Azoospermia (HP:0000027)	3.08813810
12	Colon cancer (HP:0003003)	3.02037121
13	Abnormality of the corticospinal tract (HP:0002492)	2.99418355
14	Renal cortical cysts (HP:0000803)	2.98479557
15	Abnormality of the renal cortex (HP:0011035)	2.92784222
16	Drooling (HP:0002307)	2.89103338
17	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.75745819
18	Broad-based gait (HP:0002136)	2.73208642
19	Excessive salivation (HP:0003781)	2.63458191
20	Hyperventilation (HP:0002883)	2.55302990
21	Broad face (HP:0000283)	2.54926903
22	Retinal dysplasia (HP:0007973)	2.54411339
23	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.54193484
24	Short 1st metacarpal (HP:0010034)	2.54193484
25	Pancreatic cysts (HP:0001737)	2.50767478
26	Tetraplegia (HP:0002445)	2.46816426
27	Nephronophthisis (HP:0000090)	2.46684975
28	Fibular aplasia (HP:0002990)	2.46156130
29	Limb dystonia (HP:0002451)	2.45194807
30	Congenital stationary night blindness (HP:0007642)	2.43182044
31	Stenosis of the external auditory canal (HP:0000402)	2.41395851
32	Hip dysplasia (HP:0001385)	2.40597318
33	Abnormality of the middle phalanges of the toes (HP:0010183)	2.39442130
34	Acute necrotizing encephalopathy (HP:0006965)	2.38494916
35	Chronic hepatic failure (HP:0100626)	2.34752298
36	Humeroradial synostosis (HP:0003041)	2.31796470
37	Synostosis involving the elbow (HP:0003938)	2.31796470
38	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.30627538
39	Adactyly (HP:0009776)	2.29506512
40	2-3 toe syndactyly (HP:0004691)	2.27161922
41	True hermaphroditism (HP:0010459)	2.25368145
42	Hyperglycinemia (HP:0002154)	2.24466073
43	Cutaneous finger syndactyly (HP:0010554)	2.23484486
44	Abnormality of the 1st metacarpal (HP:0010009)	2.22711786
45	Type II lissencephaly (HP:0007260)	2.21013346
46	Abnormality of the ischium (HP:0003174)	2.21004263
47	Calf muscle hypertrophy (HP:0008981)	2.19888321
48	Hypoplastic pelvis (HP:0008839)	2.19106383
49	Abnormality of the lower motor neuron (HP:0002366)	2.18166467
50	Shawl scrotum (HP:0000049)	2.17535098
51	Abnormality of cells of the erythroid lineage (HP:0012130)	2.14618059
52	Pachygyria (HP:0001302)	2.11098491
53	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.10758825
54	Increased CSF lactate (HP:0002490)	2.10412386
55	Hepatoblastoma (HP:0002884)	2.08175808
56	Spastic tetraplegia (HP:0002510)	2.07909662
57	Abnormal mitochondria in muscle tissue (HP:0008316)	2.06690846
58	Progressive macrocephaly (HP:0004481)	2.06046201
59	Abnormal spermatogenesis (HP:0008669)	2.05224574
60	3-Methylglutaconic aciduria (HP:0003535)	2.04971486
61	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.00598700
62	Hypoplastic ischia (HP:0003175)	2.00525287
63	Decreased lacrimation (HP:0000633)	2.00416347
64	Pancreatic fibrosis (HP:0100732)	1.98496104
65	Flat face (HP:0012368)	1.98092362
66	Anencephaly (HP:0002323)	1.97610236
67	Abnormality of the renal medulla (HP:0100957)	1.97588591
68	Morphological abnormality of the pyramidal tract (HP:0002062)	1.96912498
69	Decreased muscle mass (HP:0003199)	1.96745105
70	Hypoplastic labia majora (HP:0000059)	1.96575418
71	Agitation (HP:0000713)	1.94929255
72	Abnormal number of erythroid precursors (HP:0012131)	1.94644752
73	Hepatic necrosis (HP:0002605)	1.92698680
74	Labial hypoplasia (HP:0000066)	1.91491386
75	Acute encephalopathy (HP:0006846)	1.91221151
76	Abolished electroretinogram (ERG) (HP:0000550)	1.87897903
77	Lissencephaly (HP:0001339)	1.87562706
78	Muscle hypertrophy of the lower extremities (HP:0008968)	1.87464897
79	Congenital sensorineural hearing impairment (HP:0008527)	1.86126073
80	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.82784887
81	Hyperglycinuria (HP:0003108)	1.82638143
82	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.81413411
83	Hepatocellular necrosis (HP:0001404)	1.81405504
84	Tubular atrophy (HP:0000092)	1.79952557
85	Renal hypoplasia (HP:0000089)	1.79349205
86	Postaxial hand polydactyly (HP:0001162)	1.78938705
87	Abnormality of DNA repair (HP:0003254)	1.78216889
88	Abnormality of the labia majora (HP:0012881)	1.77748699
89	Narrow forehead (HP:0000341)	1.76871086
90	Hypoplasia of the radius (HP:0002984)	1.75986117
91	Protruding tongue (HP:0010808)	1.75415542
92	Mitochondrial inheritance (HP:0001427)	1.74489406
93	Abnormality of salivation (HP:0100755)	1.74131985
94	Sclerocornea (HP:0000647)	1.73539604
95	Inability to walk (HP:0002540)	1.73416102
96	Abnormality of serine family amino acid metabolism (HP:0010894)	1.72263694
97	Abnormality of glycine metabolism (HP:0010895)	1.72263694
98	Short phalanx of the thumb (HP:0009660)	1.71933250
99	Genetic anticipation (HP:0003743)	1.70292310
100	Optic disc pallor (HP:0000543)	1.70162348

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	5.62748723
2	NME1	5.36324592
3	MAPK13	2.89682361
4	EPHA4	2.84788701
5	FRK	2.72866680
6	WNK3	2.53414130
7	ERBB3	2.14328946
8	EIF2AK1	1.97692541
9	NUAK1	1.94920648
10	MARK1	1.92722069
11	DYRK2	1.88792851
12	BCKDK	1.85766647
13	PINK1	1.76909156
14	CASK	1.76687835
15	MAP3K4	1.72831421
16	TNIK	1.69317208
17	MAP2K7	1.60905753
18	TESK2	1.51148831
19	PLK4	1.44929962
20	MAP3K12	1.41715362
21	CSNK1G2	1.39935471
22	FLT3	1.31189902
23	PAK3	1.27856272
24	OXSR1	1.27635167
25	LIMK1	1.23439257
26	ZAK	1.22967550
27	GRK1	1.22156807
28	ADRBK2	1.20558674
29	NTRK2	1.19944064
30	MAP3K9	1.14979221
31	RPS6KA4	1.12619550
32	TESK1	1.12436553
33	MUSK	1.11640568
34	NTRK3	1.08133257
35	SIK2	1.04271649
36	WNK4	1.03808458
37	BCR	1.01452070
38	PRKCE	0.98762324
39	PIK3CG	0.98626794
40	PIK3CA	0.98081702
41	MAPKAPK3	0.97311495
42	TLK1	0.96761234
43	EIF2AK3	0.96290588
44	PRKD3	0.95751527
45	STK16	0.93558270
46	PKN2	0.91059929
47	CSNK1G3	0.90828354
48	SRPK1	0.88413839
49	DYRK3	0.88286022
50	PKN1	0.87076722
51	CSNK1G1	0.85661537
52	MAP2K4	0.82101537
53	STK39	0.81029379
54	LATS1	0.81021798
55	DAPK2	0.77784057
56	INSRR	0.77473568
57	TIE1	0.76454838
58	PLK2	0.76432467
59	CSNK1A1L	0.75835161
60	PIM2	0.74381366
61	ROCK1	0.72637919
62	STK38L	0.71921186
63	CAMK2B	0.65568536
64	FGFR2	0.65331167
65	CAMK1	0.65133821
66	PAK6	0.64709435
67	KSR1	0.62701180
68	PNCK	0.60095398
69	OBSCN	0.59173394
70	CAMK4	0.58957290
71	TAOK1	0.58906107
72	PRKCG	0.56931509
73	CAMK2G	0.56889522
74	CAMK2D	0.56866947
75	MAPKAPK5	0.52879640
76	PRKACA	0.52409312
77	RPS6KB2	0.50555940
78	TRIM28	0.49338092
79	RAF1	0.47205086
80	CAMK2A	0.45393498
81	ARAF	0.45301184
82	UHMK1	0.43394480
83	PHKG1	0.41254493
84	PHKG2	0.41254493
85	NEK9	0.40953073
86	PRKD2	0.39493965
87	CDK19	0.36639892
88	PRKCQ	0.36572541
89	NEK1	0.35808814
90	RPS6KA5	0.35741664
91	ATR	0.35443161
92	CAMK1G	0.35433874
93	RPS6KA2	0.33633545
94	BMPR1B	0.33348818
95	AURKA	0.32178827
96	PRKCH	0.30782252
97	PTK2B	0.29893281
98	CDK5	0.29250929
99	MINK1	0.29201812
100	CAMKK2	0.29077668

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.61370006
2	Steroid biosynthesis_Homo sapiens_hsa00100	3.10658865
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.03756770
4	Selenocompound metabolism_Homo sapiens_hsa00450	2.90018564
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.33618327
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.32654293
7	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.16533276
8	Regulation of autophagy_Homo sapiens_hsa04140	2.14305887
9	Parkinsons disease_Homo sapiens_hsa05012	2.02202123
10	One carbon pool by folate_Homo sapiens_hsa00670	2.00314395
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.97453192
12	Phototransduction_Homo sapiens_hsa04744	1.97321072
13	Retinol metabolism_Homo sapiens_hsa00830	1.94519466
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.87531152
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.86464806
16	Butanoate metabolism_Homo sapiens_hsa00650	1.76947668
17	Caffeine metabolism_Homo sapiens_hsa00232	1.76736635
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.76488948
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.75189035
20	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.70943847
21	Basal transcription factors_Homo sapiens_hsa03022	1.68244441
22	Taste transduction_Homo sapiens_hsa04742	1.65141721
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.59362795
24	Protein export_Homo sapiens_hsa03060	1.55662296
25	Huntingtons disease_Homo sapiens_hsa05016	1.54148631
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.52660279
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.48185460
28	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.46304039
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.44688789
30	Morphine addiction_Homo sapiens_hsa05032	1.42695672
31	Alzheimers disease_Homo sapiens_hsa05010	1.40923694
32	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.37299769
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.35796212
34	Olfactory transduction_Homo sapiens_hsa04740	1.25393187
35	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.22092734
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.21348048
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.17308923
38	Non-homologous end-joining_Homo sapiens_hsa03450	1.12074824
39	Salivary secretion_Homo sapiens_hsa04970	1.12004113
40	Glutamatergic synapse_Homo sapiens_hsa04724	1.07817710
41	Propanoate metabolism_Homo sapiens_hsa00640	1.06278696
42	RNA degradation_Homo sapiens_hsa03018	1.04841590
43	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.04442031
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03961040
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03268983
46	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.02138124
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.01218698
48	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.99452903
49	Ether lipid metabolism_Homo sapiens_hsa00565	0.96669428
50	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.96110863
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96089763
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.95543756
53	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.93715123
54	Nucleotide excision repair_Homo sapiens_hsa03420	0.91703231
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91152025
56	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.90863683
57	Bile secretion_Homo sapiens_hsa04976	0.88922126
58	GABAergic synapse_Homo sapiens_hsa04727	0.88763711
59	Fat digestion and absorption_Homo sapiens_hsa04975	0.87221033
60	RNA polymerase_Homo sapiens_hsa03020	0.86996631
61	Histidine metabolism_Homo sapiens_hsa00340	0.84935478
62	Circadian entrainment_Homo sapiens_hsa04713	0.83000081
63	Circadian rhythm_Homo sapiens_hsa04710	0.82030673
64	Homologous recombination_Homo sapiens_hsa03440	0.76718838
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.74833698
66	ABC transporters_Homo sapiens_hsa02010	0.74744047
67	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.74527772
68	Purine metabolism_Homo sapiens_hsa00230	0.74073543
69	Metabolic pathways_Homo sapiens_hsa01100	0.73842898
70	Insulin secretion_Homo sapiens_hsa04911	0.73676229
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70846379
72	Calcium signaling pathway_Homo sapiens_hsa04020	0.68452673
73	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.65347538
74	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.63743592
75	Lysine degradation_Homo sapiens_hsa00310	0.60986613
76	Ribosome_Homo sapiens_hsa03010	0.59571079
77	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.56897432
78	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.53134667
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.46264773
80	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.45892707
81	Serotonergic synapse_Homo sapiens_hsa04726	0.44417747
82	Peroxisome_Homo sapiens_hsa04146	0.44394015
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.43974998
84	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43858417
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43438273
86	Hippo signaling pathway_Homo sapiens_hsa04390	0.42342135
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.40837449
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.39628268
89	Fatty acid degradation_Homo sapiens_hsa00071	0.38832597
90	Axon guidance_Homo sapiens_hsa04360	0.38677863
91	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.37804021
92	Gastric acid secretion_Homo sapiens_hsa04971	0.37684394
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.36412131
94	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.36221546
95	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.35096313
96	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.34184561
97	PPAR signaling pathway_Homo sapiens_hsa03320	0.33774092
98	Sphingolipid metabolism_Homo sapiens_hsa00600	0.33721534
99	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.33671639
100	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.33539534

TBCAP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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