TBCAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of growth hormone secretion (GO:0060124)6.74847313
2protein neddylation (GO:0045116)5.79718150
3cullin deneddylation (GO:0010388)5.65302790
4positive regulation of microtubule polymerization (GO:0031116)5.50524752
5regulation of dopamine secretion (GO:0014059)5.35194409
6positive regulation of microtubule polymerization or depolymerization (GO:0031112)5.17035169
7regulation of growth hormone secretion (GO:0060123)4.93359274
8growth hormone secretion (GO:0030252)4.84473971
9protein deneddylation (GO:0000338)4.78920460
10histone H3-K9 methylation (GO:0051567)4.76751612
11regulation of microtubule polymerization (GO:0031113)4.72327261
12sequestering of actin monomers (GO:0042989)4.52536195
13positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.48646472
14microtubule depolymerization (GO:0007019)4.46849086
15negative regulation of microtubule polymerization (GO:0031115)4.35290276
16chaperone-mediated protein complex assembly (GO:0051131)4.17065514
17establishment of protein localization to mitochondrial membrane (GO:0090151)3.94605443
18chromatin remodeling at centromere (GO:0031055)3.92174484
19histone H3-K9 modification (GO:0061647)3.71219467
20histone H3-K4 trimethylation (GO:0080182)3.67014217
21CENP-A containing nucleosome assembly (GO:0034080)3.65327953
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63172967
23single strand break repair (GO:0000012)3.59217666
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56709698
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.56709698
26NADH dehydrogenase complex assembly (GO:0010257)3.56709698
27protein import into peroxisome matrix (GO:0016558)3.54226693
28water-soluble vitamin biosynthetic process (GO:0042364)3.43782686
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40830317
30protein targeting to Golgi (GO:0000042)3.40538059
31seminiferous tubule development (GO:0072520)3.39521561
32dopamine transport (GO:0015872)3.38615407
33termination of G-protein coupled receptor signaling pathway (GO:0038032)3.36045221
34microtubule polymerization or depolymerization (GO:0031109)3.35024413
35protein complex biogenesis (GO:0070271)3.30635132
36monoubiquitinated protein deubiquitination (GO:0035520)3.29477044
37establishment of protein localization to Golgi (GO:0072600)3.26257371
38alkaloid metabolic process (GO:0009820)3.23993318
39behavioral response to nicotine (GO:0035095)3.21813603
40phosphatidylserine acyl-chain remodeling (GO:0036150)3.18253278
41kinetochore organization (GO:0051383)3.18051550
42inner ear receptor cell development (GO:0060119)3.17087519
43phosphatidylinositol acyl-chain remodeling (GO:0036149)3.16855683
44platelet dense granule organization (GO:0060155)3.15002710
45kinetochore assembly (GO:0051382)3.12431101
46DNA replication-dependent nucleosome organization (GO:0034723)3.11059617
47DNA replication-dependent nucleosome assembly (GO:0006335)3.11059617
48regulation of catecholamine secretion (GO:0050433)3.09981037
49nonmotile primary cilium assembly (GO:0035058)3.09279431
50phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.08066053
51intracellular protein transmembrane import (GO:0044743)3.07481447
52left/right axis specification (GO:0070986)3.06640968
53retinal cone cell development (GO:0046549)3.06162924
54termination of signal transduction (GO:0023021)3.04904311
55DNA replication-independent nucleosome organization (GO:0034724)3.04724368
56DNA replication-independent nucleosome assembly (GO:0006336)3.04724368
57histone exchange (GO:0043486)3.03341498
58regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)3.01712746
59centriole replication (GO:0007099)2.98707013
60cAMP-mediated signaling (GO:0019933)2.96791068
61regulation of centriole replication (GO:0046599)2.96483879
62DNA replication checkpoint (GO:0000076)2.94668717
63dopamine biosynthetic process (GO:0042416)2.94438011
64retrograde transport, vesicle recycling within Golgi (GO:0000301)2.94329995
65deoxyribonucleotide biosynthetic process (GO:0009263)2.93276546
66determination of adult lifespan (GO:0008340)2.92783399
67tyrosine metabolic process (GO:0006570)2.90242175
68mitochondrial respiratory chain complex assembly (GO:0033108)2.89987477
69parental behavior (GO:0060746)2.87636877
70protein localization to Golgi apparatus (GO:0034067)2.85327264
71rRNA methylation (GO:0031167)2.84539976
72mechanosensory behavior (GO:0007638)2.84218331
73phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.83161573
74ATP synthesis coupled proton transport (GO:0015986)2.81956751
75energy coupled proton transport, down electrochemical gradient (GO:0015985)2.81956751
76DNA double-strand break processing (GO:0000729)2.80983687
77negative regulation of DNA-dependent DNA replication (GO:2000104)2.80694431
78C4-dicarboxylate transport (GO:0015740)2.77370930
79maternal behavior (GO:0042711)2.76246486
80coenzyme A biosynthetic process (GO:0015937)2.74721102
81polyol catabolic process (GO:0046174)2.72156564
82rRNA modification (GO:0000154)2.69423136
83oxidative demethylation (GO:0070989)2.69416437
84rRNA catabolic process (GO:0016075)2.67649597
85regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.66877215
86regulation of gene expression by genetic imprinting (GO:0006349)2.60963958
87inositol phosphate-mediated signaling (GO:0048016)2.60891981
88intestinal epithelial cell development (GO:0060576)2.59114794
89regulation of amine transport (GO:0051952)2.55241892
90catechol-containing compound biosynthetic process (GO:0009713)2.55234513
91catecholamine biosynthetic process (GO:0042423)2.55234513
92regulation of energy homeostasis (GO:2000505)2.54204625
93neuron fate determination (GO:0048664)2.54121208
94spermatid nucleus differentiation (GO:0007289)2.52461228
95phosphatidylcholine acyl-chain remodeling (GO:0036151)2.51127993
96transcription elongation from RNA polymerase III promoter (GO:0006385)2.49825178
97termination of RNA polymerase III transcription (GO:0006386)2.49825178
98respiratory chain complex IV assembly (GO:0008535)2.48306653
99histone mRNA metabolic process (GO:0008334)2.47158361
100axoneme assembly (GO:0035082)2.46443880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.77704771
2EZH2_22144423_ChIP-Seq_EOC_Human3.70872296
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.47492719
4ZNF274_21170338_ChIP-Seq_K562_Hela3.05993733
5GBX2_23144817_ChIP-Seq_PC3_Human3.00018460
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.83410766
7VDR_22108803_ChIP-Seq_LS180_Human2.61898661
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44434574
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.42489435
10MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38752699
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24231701
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23527970
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20074396
14P300_19829295_ChIP-Seq_ESCs_Human2.19362558
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12471107
16EWS_26573619_Chip-Seq_HEK293_Human2.06859316
17FUS_26573619_Chip-Seq_HEK293_Human2.05888673
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95682247
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.95682247
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.91065259
21SUZ12_27294783_Chip-Seq_NPCs_Mouse1.88004265
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86747884
23ER_23166858_ChIP-Seq_MCF-7_Human1.86625994
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.84445313
25IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.83717936
26CBP_20019798_ChIP-Seq_JUKART_Human1.83717936
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.83397563
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79110396
29UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.78261518
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.77568464
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75172879
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69438407
33TP53_16413492_ChIP-PET_HCT116_Human1.69073550
34BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.68278866
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64614994
36TAF15_26573619_Chip-Seq_HEK293_Human1.61211181
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56391414
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53902943
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.52731314
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.43128687
41ELK1_19687146_ChIP-ChIP_HELA_Human1.43117424
42RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42640161
43CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40246052
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40170628
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40165700
46TP53_22573176_ChIP-Seq_HFKS_Human1.39200305
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.39041897
48VDR_23849224_ChIP-Seq_CD4+_Human1.39012828
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38777092
50AR_20517297_ChIP-Seq_VCAP_Human1.38196786
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37838529
52CRX_20693478_ChIP-Seq_RETINA_Mouse1.37657885
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36357530
54AR_25329375_ChIP-Seq_VCAP_Human1.33145277
55SMAD4_21799915_ChIP-Seq_A2780_Human1.31837636
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31683545
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30634333
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28434847
59STAT3_23295773_ChIP-Seq_U87_Human1.28370020
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26664114
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.26664114
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.25138673
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24205547
64MYC_18940864_ChIP-ChIP_HL60_Human1.23673514
65P53_22387025_ChIP-Seq_ESCs_Mouse1.23138982
66TCF4_23295773_ChIP-Seq_U87_Human1.23053676
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22932347
68BCAT_22108803_ChIP-Seq_LS180_Human1.21797141
69SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.20830507
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19264455
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.18461986
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18328703
73CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.16995500
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.16520857
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15420419
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14614192
77OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13543166
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.13158064
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13045967
80STAT3_18555785_Chip-Seq_ESCs_Mouse1.12982692
81TCF4_22108803_ChIP-Seq_LS180_Human1.10923309
82JUN_21703547_ChIP-Seq_K562_Human1.09157415
83SOX2_19829295_ChIP-Seq_ESCs_Human1.08443099
84NANOG_19829295_ChIP-Seq_ESCs_Human1.08443099
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08288033
86SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07801471
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07148850
88EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06888146
89RUNX2_22187159_ChIP-Seq_PCA_Human1.06467061
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04097618
91P300_18555785_Chip-Seq_ESCs_Mouse1.03760451
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03513270
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02619423
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.01893435
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.01871882
96REST_21632747_ChIP-Seq_MESCs_Mouse1.01782572
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00219170
98MYC_19829295_ChIP-Seq_ESCs_Human1.00128754
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.97836863
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.96428636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting5.87883100
2MP0008877_abnormal_DNA_methylation5.28855460
3MP0003122_maternal_imprinting4.22525230
4MP0001501_abnormal_sleep_pattern3.18712876
5MP0003121_genomic_imprinting3.01276704
6MP0002837_dystrophic_cardiac_calcinosis2.95386451
7MP0006292_abnormal_olfactory_placode2.74621070
8MP0004043_abnormal_pH_regulation2.73760726
9MP0002102_abnormal_ear_morphology2.55124379
10MP0005551_abnormal_eye_electrophysiolog2.47083264
11MP0000569_abnormal_digit_pigmentation2.45586941
12MP0003123_paternal_imprinting2.43786936
13MP0004885_abnormal_endolymph2.21247294
14MP0002736_abnormal_nociception_after2.09919608
15MP0003045_fibrosis2.01389092
16MP0005084_abnormal_gallbladder_morpholo1.96231723
17MP0000631_abnormal_neuroendocrine_gland1.95270362
18MP0000372_irregular_coat_pigmentation1.87067338
19MP0006072_abnormal_retinal_apoptosis1.83291822
20MP0003303_peritoneal_inflammation1.57942695
21MP0002938_white_spotting1.56383143
22MP0005187_abnormal_penis_morphology1.55615729
23MP0003890_abnormal_embryonic-extraembry1.50625618
24MP0004134_abnormal_chest_morphology1.50293755
25MP0009697_abnormal_copulation1.47247799
26MP0003567_abnormal_fetal_cardiomyocyte1.47044738
27MP0002272_abnormal_nervous_system1.46366383
28MP0002653_abnormal_ependyma_morphology1.45980659
29MP0001881_abnormal_mammary_gland1.38627130
30MP0005083_abnormal_biliary_tract1.37661667
31MP0004142_abnormal_muscle_tone1.36929723
32MP0009046_muscle_twitch1.35929430
33MP0005266_abnormal_metabolism1.32678520
34MP0005253_abnormal_eye_physiology1.28174390
35MP0001968_abnormal_touch/_nociception1.25663788
36MP0002557_abnormal_social/conspecific_i1.23306255
37MP0001529_abnormal_vocalization1.21410643
38MP0008789_abnormal_olfactory_epithelium1.20178883
39MP0006036_abnormal_mitochondrial_physio1.18494078
40MP0001485_abnormal_pinna_reflex1.16647988
41MP0008057_abnormal_DNA_replication1.16276582
42MP0004133_heterotaxia1.13454780
43MP0003950_abnormal_plasma_membrane1.11128342
44MP0003868_abnormal_feces_composition1.09755732
45MP0002168_other_aberrant_phenotype1.09562185
46MP0001764_abnormal_homeostasis1.08907777
47MP0005376_homeostasis/metabolism_phenot1.06861510
48MP0006035_abnormal_mitochondrial_morpho1.05974151
49MP0003937_abnormal_limbs/digits/tail_de1.03403350
50MP0005410_abnormal_fertilization1.02978676
51MP0008872_abnormal_physiological_respon1.02974007
52MP0001963_abnormal_hearing_physiology1.00997874
53MP0004957_abnormal_blastocyst_morpholog0.97626518
54MP0002067_abnormal_sensory_capabilities0.97621747
55MP0000049_abnormal_middle_ear0.96703917
56MP0006276_abnormal_autonomic_nervous0.96207948
57MP0003221_abnormal_cardiomyocyte_apopto0.95035727
58MP0002638_abnormal_pupillary_reflex0.94730925
59MP0001486_abnormal_startle_reflex0.94534350
60MP0005332_abnormal_amino_acid0.93013184
61MP0005075_abnormal_melanosome_morpholog0.92679200
62MP0002229_neurodegeneration0.91050784
63MP0005386_behavior/neurological_phenoty0.90637626
64MP0004924_abnormal_behavior0.90637626
65MP0004145_abnormal_muscle_electrophysio0.89566112
66MP0001293_anophthalmia0.89378430
67MP0000026_abnormal_inner_ear0.87977292
68MP0008058_abnormal_DNA_repair0.87146594
69MP0003119_abnormal_digestive_system0.86884600
70MP0002572_abnormal_emotion/affect_behav0.86803452
71MP0004883_abnormal_blood_vessel0.82849274
72MP0005195_abnormal_posterior_eye0.82328623
73MP0002332_abnormal_exercise_endurance0.82142987
74MP0005394_taste/olfaction_phenotype0.82121535
75MP0005499_abnormal_olfactory_system0.82121535
76MP0001929_abnormal_gametogenesis0.80603066
77MP0000647_abnormal_sebaceous_gland0.80210192
78MP0002751_abnormal_autonomic_nervous0.75373335
79MP0002090_abnormal_vision0.73867919
80MP0009745_abnormal_behavioral_response0.73809786
81MP0005310_abnormal_salivary_gland0.73572358
82MP0000230_abnormal_systemic_arterial0.73261907
83MP0002752_abnormal_somatic_nervous0.72152827
84MP0009379_abnormal_foot_pigmentation0.71416427
85MP0004215_abnormal_myocardial_fiber0.70820301
86MP0002177_abnormal_outer_ear0.70170816
87MP0001324_abnormal_eye_pigmentation0.69012877
88MP0001440_abnormal_grooming_behavior0.68724263
89MP0001919_abnormal_reproductive_system0.67654321
90MP0000470_abnormal_stomach_morphology0.66574235
91MP0008875_abnormal_xenobiotic_pharmacok0.66209615
92MP0004084_abnormal_cardiac_muscle0.65968338
93MP0002095_abnormal_skin_pigmentation0.64161415
94MP0003698_abnormal_male_reproductive0.63477677
95MP0005220_abnormal_exocrine_pancreas0.62201263
96MP0003786_premature_aging0.61617242
97MP0000653_abnormal_sex_gland0.61525672
98MP0002064_seizures0.60240572
99MP0002063_abnormal_learning/memory/cond0.59254737
100MP0001986_abnormal_taste_sensitivity0.59235037

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)5.20808939
2Renal cortical cysts (HP:0000803)4.35803638
3Global brain atrophy (HP:0002283)4.01908857
4Dyschromatopsia (HP:0007641)3.83040446
5Colon cancer (HP:0003003)3.81920283
6Acute necrotizing encephalopathy (HP:0006965)3.60512653
7Oligodactyly (hands) (HP:0001180)3.48011980
8Abnormality of alanine metabolism (HP:0010916)3.37396217
9Hyperalaninemia (HP:0003348)3.37396217
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.37396217
11Nephronophthisis (HP:0000090)3.33111034
12Limb dystonia (HP:0002451)3.26812090
13Acute encephalopathy (HP:0006846)3.26056802
14Congenital stationary night blindness (HP:0007642)3.21589903
15Abnormal number of erythroid precursors (HP:0012131)3.18506006
16Abnormality of the renal cortex (HP:0011035)3.14115767
17Chronic hepatic failure (HP:0100626)3.13385242
18Abnormality of midbrain morphology (HP:0002418)3.12737958
19Molar tooth sign on MRI (HP:0002419)3.12737958
20Stenosis of the external auditory canal (HP:0000402)3.08357375
21Medial flaring of the eyebrow (HP:0010747)3.08037226
22Progressive macrocephaly (HP:0004481)3.06115823
23Gait imbalance (HP:0002141)2.98583021
24Tubulointerstitial nephritis (HP:0001970)2.94841799
25Abnormal mitochondria in muscle tissue (HP:0008316)2.80360856
26Congenital primary aphakia (HP:0007707)2.79917255
27Abnormality of cells of the erythroid lineage (HP:0012130)2.79115434
28Growth hormone deficiency (HP:0000824)2.75996306
29Increased CSF lactate (HP:0002490)2.71127390
30Protruding tongue (HP:0010808)2.71014752
31Focal motor seizures (HP:0011153)2.67218240
32Mitochondrial inheritance (HP:0001427)2.63743057
333-Methylglutaconic aciduria (HP:0003535)2.61144335
34Abnormality of the renal medulla (HP:0100957)2.59063420
35Cerebral edema (HP:0002181)2.58266866
36Tubular atrophy (HP:0000092)2.55898122
37Acute lymphatic leukemia (HP:0006721)2.55164718
38Pancreatic fibrosis (HP:0100732)2.54896376
39Nephrogenic diabetes insipidus (HP:0009806)2.54663762
40Pancreatic cysts (HP:0001737)2.52602387
41Enlarged kidneys (HP:0000105)2.52112765
42Microvesicular hepatic steatosis (HP:0001414)2.50954547
43Congenital, generalized hypertrichosis (HP:0004540)2.49689702
44True hermaphroditism (HP:0010459)2.48680037
45Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.40086690
46Optic disc pallor (HP:0000543)2.37127794
47Pancreatic islet-cell hyperplasia (HP:0004510)2.34493374
48Constricted visual fields (HP:0001133)2.29302482
49Sensory axonal neuropathy (HP:0003390)2.23849608
50Dyskinesia (HP:0100660)2.22762824
51Stomach cancer (HP:0012126)2.19685467
52Poor head control (HP:0002421)2.18351307
53Volvulus (HP:0002580)2.17823811
54Neoplasm of the adrenal cortex (HP:0100641)2.14262274
55Optic nerve hypoplasia (HP:0000609)2.11172996
56Oligodactyly (HP:0012165)2.08241402
57Leukodystrophy (HP:0002415)2.06824329
58Abnormality of serum amino acid levels (HP:0003112)2.04292882
59Hepatic necrosis (HP:0002605)2.03052994
60Congenital hepatic fibrosis (HP:0002612)2.01299098
61Progressive cerebellar ataxia (HP:0002073)1.99929155
62Vaginal atresia (HP:0000148)1.99265295
63Anencephaly (HP:0002323)1.98367092
64Poor coordination (HP:0002370)1.96471377
65Decreased testicular size (HP:0008734)1.96165898
66Hypochromic microcytic anemia (HP:0004840)1.95833428
67Central scotoma (HP:0000603)1.95071717
68Anophthalmia (HP:0000528)1.94663511
69Hepatocellular necrosis (HP:0001404)1.94504559
70Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94330789
71Decreased circulating renin level (HP:0003351)1.93684005
72Poor suck (HP:0002033)1.89364291
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89091232
74Genital tract atresia (HP:0001827)1.88656983
75Drooling (HP:0002307)1.88088098
76Hyperinsulinemic hypoglycemia (HP:0000825)1.84761234
77Macroglossia (HP:0000158)1.83209422
78Long nose (HP:0003189)1.80972249
79Respiratory failure (HP:0002878)1.79940232
80Fibular hypoplasia (HP:0003038)1.79631387
81Medulloblastoma (HP:0002885)1.78990673
82Short chin (HP:0000331)1.78762325
83Sclerocornea (HP:0000647)1.78724249
84Tachypnea (HP:0002789)1.78360427
85Scrotal hypoplasia (HP:0000046)1.76256481
86Broad-based gait (HP:0002136)1.75750192
87Furrowed tongue (HP:0000221)1.72456380
88Abnormal ciliary motility (HP:0012262)1.72257466
89Supernumerary spleens (HP:0009799)1.70753491
90Increased serum lactate (HP:0002151)1.70446530
91Abnormality of the labia minora (HP:0012880)1.70185066
92Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.68558818
93Excessive salivation (HP:0003781)1.68089110
94Scotoma (HP:0000575)1.67883097
95Short foot (HP:0001773)1.67619308
96Epidermoid cyst (HP:0200040)1.66353607
97Testicular atrophy (HP:0000029)1.64315424
98Partial agenesis of the corpus callosum (HP:0001338)1.64270195
99Hypoglycemic coma (HP:0001325)1.63326963
100Hyperventilation (HP:0002883)1.63116004

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.93967551
2BCR3.59373623
3PNCK3.31649876
4MAPK133.09493705
5PLK42.79475591
6TIE12.62321148
7TNIK2.34113139
8MAP4K22.30531094
9NEK92.25585946
10CAMKK22.17470092
11UHMK12.03376217
12MKNK22.00013776
13CSNK1G11.97919658
14WEE11.96660248
15CSNK1G31.95578352
16TLK11.93006204
17MAP3K121.69692765
18NTRK21.65982262
19CSNK1A1L1.62469348
20PKN11.60790143
21CSNK1G21.57764299
22MKNK11.55674670
23TRIM281.54645459
24EIF2AK21.41870243
25GRK11.39270300
26PTK2B1.34209423
27ACVR1B1.33461272
28NTRK31.32727173
29FRK1.30120612
30BMPR1B1.26737850
31TEC1.26269512
32PIK3CG1.25609441
33MAP3K41.24288881
34PLK21.22828257
35VRK11.21210771
36BRSK21.13439371
37TSSK61.11156679
38CAMK2B1.10231426
39PLK31.08498268
40NUAK11.07703284
41MAPKAPK51.07178472
42DYRK21.05218011
43STK161.02226620
44CAMK41.01271516
45MINK10.98187544
46TAF10.95883860
47MARK10.93489906
48INSRR0.89045845
49ADRBK20.87568453
50CHEK20.86641437
51ADRBK10.83886545
52CAMK1G0.79343990
53SRPK10.75109806
54NME10.72794117
55PRKCG0.71068124
56CAMK1D0.69910918
57PDK20.69247745
58FLT30.67512234
59ZAK0.65908278
60CASK0.65280817
61CAMK2A0.65199942
62KDR0.65128860
63MAPK40.64823470
64ERBB30.60715982
65CDK140.60620346
66PLK10.59304517
67MAP2K70.58689405
68CAMK10.56338522
69BUB10.56164750
70NEK10.53605981
71PRKG10.52910985
72PRKCQ0.52459221
73OXSR10.50879195
74CDK180.48271056
75CSNK1A10.47877554
76NEK20.46933686
77STK100.46550987
78PIK3CA0.45788338
79PAK30.45658842
80CDK150.43849736
81PRKACA0.43426684
82TYRO30.42269255
83CAMK2D0.41655436
84CHUK0.41486830
85EIF2AK30.41371119
86MST40.40857300
87CSNK1D0.40613532
88STK110.37687539
89IKBKB0.37261493
90CDK11A0.35137690
91CSNK2A10.34239294
92ATM0.34136413
93TGFBR10.33736379
94GRK70.33587882
95LIMK10.31866097
96MAPK150.31761877
97PRKCB0.31377832
98CSNK1E0.30957603
99MAP2K10.30884334
100CDK30.30356719

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.23499051
2Protein export_Homo sapiens_hsa030604.13926379
3Linoleic acid metabolism_Homo sapiens_hsa005914.09978921
4Basal transcription factors_Homo sapiens_hsa030223.35367848
5Nicotine addiction_Homo sapiens_hsa050333.14193096
6Oxidative phosphorylation_Homo sapiens_hsa001903.04548755
7Nitrogen metabolism_Homo sapiens_hsa009102.57571079
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57013580
9Parkinsons disease_Homo sapiens_hsa050122.56370577
10Ether lipid metabolism_Homo sapiens_hsa005652.17544921
11Phototransduction_Homo sapiens_hsa047441.97558842
12Vitamin B6 metabolism_Homo sapiens_hsa007501.80581982
13Huntingtons disease_Homo sapiens_hsa050161.79659276
14Fatty acid elongation_Homo sapiens_hsa000621.68885038
15Butanoate metabolism_Homo sapiens_hsa006501.59911161
16RNA polymerase_Homo sapiens_hsa030201.58421883
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57816869
18Alzheimers disease_Homo sapiens_hsa050101.53136930
19Homologous recombination_Homo sapiens_hsa034401.51431165
20Cardiac muscle contraction_Homo sapiens_hsa042601.47816139
21Arachidonic acid metabolism_Homo sapiens_hsa005901.44263171
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43828790
23Fatty acid biosynthesis_Homo sapiens_hsa000611.40521953
24Propanoate metabolism_Homo sapiens_hsa006401.37609422
25Nucleotide excision repair_Homo sapiens_hsa034201.30643028
26Collecting duct acid secretion_Homo sapiens_hsa049661.26342293
27Proteasome_Homo sapiens_hsa030501.25204272
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21414500
29Ribosome_Homo sapiens_hsa030101.18345967
30Cocaine addiction_Homo sapiens_hsa050301.17996936
31Fat digestion and absorption_Homo sapiens_hsa049751.17145533
32RNA transport_Homo sapiens_hsa030131.14532302
33Steroid biosynthesis_Homo sapiens_hsa001001.13899603
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12588783
35Caffeine metabolism_Homo sapiens_hsa002321.07990620
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07189410
37Glycerophospholipid metabolism_Homo sapiens_hsa005641.05422436
38Ovarian steroidogenesis_Homo sapiens_hsa049130.98528201
39Mismatch repair_Homo sapiens_hsa034300.97150406
40Regulation of autophagy_Homo sapiens_hsa041400.97068207
41RNA degradation_Homo sapiens_hsa030180.96508760
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.92674241
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91664681
44Serotonergic synapse_Homo sapiens_hsa047260.91407813
45Glutamatergic synapse_Homo sapiens_hsa047240.91207654
46Long-term depression_Homo sapiens_hsa047300.89856005
47Cholinergic synapse_Homo sapiens_hsa047250.87724031
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82788002
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80994419
50Retinol metabolism_Homo sapiens_hsa008300.75421348
51Pyrimidine metabolism_Homo sapiens_hsa002400.74104399
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73017024
53Fatty acid metabolism_Homo sapiens_hsa012120.72844386
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72748215
55Tryptophan metabolism_Homo sapiens_hsa003800.71330624
56Tyrosine metabolism_Homo sapiens_hsa003500.68396455
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.65208572
58Glutathione metabolism_Homo sapiens_hsa004800.64651795
59Chemical carcinogenesis_Homo sapiens_hsa052040.64537016
60Fatty acid degradation_Homo sapiens_hsa000710.64302420
61Peroxisome_Homo sapiens_hsa041460.64215469
62Alcoholism_Homo sapiens_hsa050340.62584129
63Dopaminergic synapse_Homo sapiens_hsa047280.60316501
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58790224
65Pyruvate metabolism_Homo sapiens_hsa006200.57718560
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57710645
67Amphetamine addiction_Homo sapiens_hsa050310.54208773
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53730611
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51941168
70Purine metabolism_Homo sapiens_hsa002300.51624185
71Mineral absorption_Homo sapiens_hsa049780.50935344
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49670948
73Insulin secretion_Homo sapiens_hsa049110.49304510
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.47458880
75Metabolic pathways_Homo sapiens_hsa011000.47427034
76Folate biosynthesis_Homo sapiens_hsa007900.45022894
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44185354
78Sulfur metabolism_Homo sapiens_hsa009200.43991321
79Glycerolipid metabolism_Homo sapiens_hsa005610.43958200
80Pancreatic secretion_Homo sapiens_hsa049720.43790828
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43758197
82Basal cell carcinoma_Homo sapiens_hsa052170.43584906
83TGF-beta signaling pathway_Homo sapiens_hsa043500.43097464
84Olfactory transduction_Homo sapiens_hsa047400.40638655
85Oxytocin signaling pathway_Homo sapiens_hsa049210.39618816
86Sulfur relay system_Homo sapiens_hsa041220.38566385
87Gastric acid secretion_Homo sapiens_hsa049710.38112907
88beta-Alanine metabolism_Homo sapiens_hsa004100.37743883
89Selenocompound metabolism_Homo sapiens_hsa004500.37346490
90DNA replication_Homo sapiens_hsa030300.35586931
91Systemic lupus erythematosus_Homo sapiens_hsa053220.34774581
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34206018
93Renin secretion_Homo sapiens_hsa049240.33441778
94Taste transduction_Homo sapiens_hsa047420.32682775
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31308027
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31145099
97Calcium signaling pathway_Homo sapiens_hsa040200.31119263
98Non-homologous end-joining_Homo sapiens_hsa034500.29846874
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.28575046
100GABAergic synapse_Homo sapiens_hsa047270.27818374

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