

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.73931122 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 5.42875598 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.42875598 |
| 4 | cullin deneddylation (GO:0010388) | 4.85122176 |
| 5 | protein neddylation (GO:0045116) | 4.76312655 |
| 6 | chaperone-mediated protein transport (GO:0072321) | 4.73550278 |
| 7 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.67703807 |
| 8 | protein deneddylation (GO:0000338) | 4.57743390 |
| 9 | proteasome assembly (GO:0043248) | 4.48475114 |
| 10 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.45177500 |
| 11 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.42492633 |
| 12 | sequestering of actin monomers (GO:0042989) | 4.32315887 |
| 13 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.27292911 |
| 14 | synaptic vesicle exocytosis (GO:0016079) | 4.24103687 |
| 15 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.23736516 |
| 16 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.22977743 |
| 17 | negative regulation of ligase activity (GO:0051352) | 4.22977743 |
| 18 | establishment of mitochondrion localization (GO:0051654) | 4.19502587 |
| 19 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.16696869 |
| 20 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.15002804 |
| 21 | protein maturation by protein folding (GO:0022417) | 4.11683474 |
| 22 | protein complex biogenesis (GO:0070271) | 4.11571079 |
| 23 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.07477239 |
| 24 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.07477239 |
| 25 | respiratory electron transport chain (GO:0022904) | 4.07475772 |
| 26 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.06028147 |
| 27 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.06028147 |
| 28 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.06028147 |
| 29 | DNA deamination (GO:0045006) | 4.01876903 |
| 30 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 4.00912347 |
| 31 | deoxyribose phosphate biosynthetic process (GO:0046385) | 4.00912347 |
| 32 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.99509126 |
| 33 | electron transport chain (GO:0022900) | 3.98946748 |
| 34 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.98895875 |
| 35 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.96550624 |
| 36 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.95640522 |
| 37 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.95640522 |
| 38 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.84024967 |
| 39 | termination of RNA polymerase III transcription (GO:0006386) | 3.84024967 |
| 40 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.82726285 |
| 41 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.80021943 |
| 42 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.78760201 |
| 43 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.78385616 |
| 44 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.78385616 |
| 45 | NADH dehydrogenase complex assembly (GO:0010257) | 3.78385616 |
| 46 | synaptic vesicle maturation (GO:0016188) | 3.78271443 |
| 47 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.77422388 |
| 48 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.77156571 |
| 49 | regulation of mitochondrial translation (GO:0070129) | 3.62711883 |
| 50 | positive regulation of ligase activity (GO:0051351) | 3.61068527 |
| 51 | oxidative phosphorylation (GO:0006119) | 3.58889303 |
| 52 | 7-methylguanosine mRNA capping (GO:0006370) | 3.57342968 |
| 53 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.55000624 |
| 54 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.54933795 |
| 55 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.53425675 |
| 56 | de novo posttranslational protein folding (GO:0051084) | 3.52646953 |
| 57 | base-excision repair, AP site formation (GO:0006285) | 3.50801099 |
| 58 | protein targeting to mitochondrion (GO:0006626) | 3.50188489 |
| 59 | RNA capping (GO:0036260) | 3.49744918 |
| 60 | 7-methylguanosine RNA capping (GO:0009452) | 3.49744918 |
| 61 | establishment of protein localization to mitochondrion (GO:0072655) | 3.49718145 |
| 62 | de novo protein folding (GO:0006458) | 3.48931296 |
| 63 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.46457814 |
| 64 | establishment of integrated proviral latency (GO:0075713) | 3.40717795 |
| 65 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.39110716 |
| 66 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.39110716 |
| 67 | formation of translation preinitiation complex (GO:0001731) | 3.38326063 |
| 68 | positive regulation of mitochondrial fission (GO:0090141) | 3.36525637 |
| 69 | maturation of SSU-rRNA (GO:0030490) | 3.33268805 |
| 70 | glutamate secretion (GO:0014047) | 3.32456136 |
| 71 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.31427127 |
| 72 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.31427127 |
| 73 | cytochrome complex assembly (GO:0017004) | 3.29380702 |
| 74 | spliceosomal snRNP assembly (GO:0000387) | 3.28601247 |
| 75 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.28266064 |
| 76 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.28063636 |
| 77 | nucleobase catabolic process (GO:0046113) | 3.27536840 |
| 78 | GTP biosynthetic process (GO:0006183) | 3.26512167 |
| 79 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.23769458 |
| 80 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.23714400 |
| 81 | protein localization to synapse (GO:0035418) | 3.23650428 |
| 82 | lipopolysaccharide biosynthetic process (GO:0009103) | 3.23437437 |
| 83 | negative regulation of microtubule polymerization (GO:0031115) | 3.23124487 |
| 84 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.22170663 |
| 85 | ribosomal small subunit assembly (GO:0000028) | 3.21014719 |
| 86 | deoxyribonucleoside diphosphate metabolic process (GO:0009186) | 3.19942495 |
| 87 | positive regulation of cell cycle arrest (GO:0071158) | 3.17925426 |
| 88 | protein localization to mitochondrion (GO:0070585) | 3.17075323 |
| 89 | regulation of cellular amine metabolic process (GO:0033238) | 3.16430360 |
| 90 | regulation of synapse structural plasticity (GO:0051823) | 3.16015094 |
| 91 | regulation of ligase activity (GO:0051340) | 3.15433751 |
| 92 | protein polyglutamylation (GO:0018095) | 3.13245201 |
| 93 | respiratory chain complex IV assembly (GO:0008535) | 3.12704181 |
| 94 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.10314613 |
| 95 | ribosomal small subunit biogenesis (GO:0042274) | 3.09834104 |
| 96 | histone arginine methylation (GO:0034969) | 3.06667338 |
| 97 | gamma-aminobutyric acid transport (GO:0015812) | 3.05502299 |
| 98 | translation (GO:0006412) | 3.05082490 |
| 99 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.03140907 |
| 100 | postsynaptic membrane organization (GO:0001941) | 2.99091709 |
| 101 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 2.98699846 |
| 102 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.98648293 |
| 103 | establishment of viral latency (GO:0019043) | 2.98196041 |
| 104 | metallo-sulfur cluster assembly (GO:0031163) | 2.98094600 |
| 105 | iron-sulfur cluster assembly (GO:0016226) | 2.98094600 |
| 106 | protein-cofactor linkage (GO:0018065) | 2.97770913 |
| 107 | viral transcription (GO:0019083) | 2.96968971 |
| 108 | platelet dense granule organization (GO:0060155) | 2.96177662 |
| 109 | peptidyl-arginine N-methylation (GO:0035246) | 2.96073640 |
| 110 | peptidyl-arginine methylation (GO:0018216) | 2.96073640 |
| 111 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.95224117 |
| 112 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.94427975 |
| 113 | mitochondrion transport along microtubule (GO:0047497) | 2.94427975 |
| 114 | neuron cell-cell adhesion (GO:0007158) | 2.93460395 |
| 115 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 2.91688515 |
| 116 | GDP-mannose metabolic process (GO:0019673) | 2.91163020 |
| 117 | negative regulation of cell cycle G1/S phase transition (GO:1902807) | 2.89618841 |
| 118 | negative regulation of G1/S transition of mitotic cell cycle (GO:2000134) | 2.89618841 |
| 119 | deoxyribonucleotide catabolic process (GO:0009264) | 2.89411393 |
| 120 | protein targeting to ER (GO:0045047) | 2.88606171 |
| 121 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.88538138 |
| 122 | cellular component biogenesis (GO:0044085) | 2.88441907 |
| 123 | mitochondrial fragmentation involved in apoptotic process (GO:0043653) | 2.88397489 |
| 124 | cotranslational protein targeting to membrane (GO:0006613) | 2.88082885 |
| 125 | translational termination (GO:0006415) | 2.87355752 |
| 126 | protein insertion into membrane (GO:0051205) | 2.86631720 |
| 127 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 2.85377541 |
| 128 | UTP biosynthetic process (GO:0006228) | 2.84909511 |
| 129 | hydrogen ion transmembrane transport (GO:1902600) | 2.84472574 |
| 130 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.83905465 |
| 131 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.81837188 |
| 132 | viral mRNA export from host cell nucleus (GO:0046784) | 2.81727900 |
| 133 | negative regulation of protein ubiquitination (GO:0031397) | 2.80541227 |
| 134 | purine deoxyribonucleotide metabolic process (GO:0009151) | 2.79966129 |
| 135 | positive regulation of TOR signaling (GO:0032008) | 2.74919337 |
| 136 | ATP biosynthetic process (GO:0006754) | 2.67441103 |
| 137 | regulation of cellular respiration (GO:0043457) | 2.66934612 |
| 138 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 2.66827065 |
| 139 | neurotransmitter secretion (GO:0007269) | 2.65622909 |
| 140 | positive regulation of release of cytochrome c from mitochondria (GO:0090200) | 2.65147487 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.70663979 |
| 2 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.21735299 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.13673751 |
| 4 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.92895813 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.80129767 |
| 6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.66782908 |
| 7 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.61319498 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.59422152 |
| 9 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.49489308 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.48258688 |
| 11 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 3.37260102 |
| 12 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.07623799 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.03963020 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.97488080 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.81495958 |
| 16 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.73041108 |
| 17 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.59631306 |
| 18 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.51518093 |
| 19 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.50495143 |
| 20 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.43055779 |
| 21 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.41643938 |
| 22 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.39590516 |
| 23 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.38283209 |
| 24 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.35047284 |
| 25 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.32551344 |
| 26 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.31049198 |
| 27 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.30527358 |
| 28 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.23264805 |
| 29 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.13421005 |
| 30 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.13253305 |
| 31 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 2.01882686 |
| 32 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.97776441 |
| 33 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.94853842 |
| 34 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.76467255 |
| 35 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.75841520 |
| 36 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.74694437 |
| 37 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.69835032 |
| 38 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.67299206 |
| 39 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.66552542 |
| 40 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.64851988 |
| 41 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.62835697 |
| 42 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.62741056 |
| 43 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.62295192 |
| 44 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.61416483 |
| 45 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.60819774 |
| 46 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.53773216 |
| 47 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.51462437 |
| 48 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.51056036 |
| 49 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.50789907 |
| 50 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.49256738 |
| 51 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.47538244 |
| 52 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.46249079 |
| 53 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.44138068 |
| 54 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.43738439 |
| 55 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.42470647 |
| 56 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.42095360 |
| 57 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.39186900 |
| 58 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.37597436 |
| 59 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.37394788 |
| 60 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.35780308 |
| 61 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.35343833 |
| 62 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.33936072 |
| 63 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.33430930 |
| 64 | P68_20966046_ChIP-Seq_HELA_Human | 1.33223945 |
| 65 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.32883775 |
| 66 | * SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.30884305 |
| 67 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.29312081 |
| 68 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.28902547 |
| 69 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.27088976 |
| 70 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.26976062 |
| 71 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.26065016 |
| 72 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.24762641 |
| 73 | CTCF_20526341_ChIP-Seq_ESCs_Human | 1.24050484 |
| 74 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.23414831 |
| 75 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.22789925 |
| 76 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 1.22573736 |
| 77 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.21242726 |
| 78 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.19526216 |
| 79 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.18750313 |
| 80 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.18460985 |
| 81 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.17196979 |
| 82 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.15342924 |
| 83 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.15336022 |
| 84 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.13248666 |
| 85 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.12611133 |
| 86 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.12079460 |
| 87 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 1.11729562 |
| 88 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.11494751 |
| 89 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.11265003 |
| 90 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.10522715 |
| 91 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.10158364 |
| 92 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.08642296 |
| 93 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.08092044 |
| 94 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.07304581 |
| 95 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.06687743 |
| 96 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.06461605 |
| 97 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.06240263 |
| 98 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.05480584 |
| 99 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.03975755 |
| 100 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.03830260 |
| 101 | VDR_22108803_ChIP-Seq_LS180_Human | 1.03707494 |
| 102 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.03654769 |
| 103 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.02915924 |
| 104 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.01038240 |
| 105 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.00911236 |
| 106 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.00774486 |
| 107 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.98323393 |
| 108 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 0.98152479 |
| 109 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.97408335 |
| 110 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.95655862 |
| 111 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.95458377 |
| 112 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.94190448 |
| 113 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.94064076 |
| 114 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.93470925 |
| 115 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 0.93358596 |
| 116 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.93144904 |
| 117 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.92462452 |
| 118 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.92342459 |
| 119 | SA1_27219007_Chip-Seq_Bcells_Human | 0.92311835 |
| 120 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.90267698 |
| 121 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.90164860 |
| 122 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 0.89374769 |
| 123 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.89154389 |
| 124 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.88984001 |
| 125 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 0.88783605 |
| 126 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 0.88432090 |
| 127 | * RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.87343511 |
| 128 | EZH2_22144423_ChIP-Seq_EOC_Human | 0.84180701 |
| 129 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.84170601 |
| 130 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.83076803 |
| 131 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.82552853 |
| 132 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.82265204 |
| 133 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.81538091 |
| 134 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.79949297 |
| 135 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.76845919 |
| 136 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.72122016 |
| 137 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.71160183 |
| 138 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.70574988 |
| 139 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.69630879 |
| 140 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.68330757 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002822_catalepsy | 3.29638548 |
| 2 | MP0006276_abnormal_autonomic_nervous | 3.06597918 |
| 3 | MP0002735_abnormal_chemical_nociception | 2.74714884 |
| 4 | MP0001986_abnormal_taste_sensitivity | 2.70281747 |
| 5 | MP0003693_abnormal_embryo_hatching | 2.63999171 |
| 6 | MP0001968_abnormal_touch/_nociception | 2.59178477 |
| 7 | MP0002736_abnormal_nociception_after | 2.55284779 |
| 8 | MP0001529_abnormal_vocalization | 2.50016708 |
| 9 | MP0008789_abnormal_olfactory_epithelium | 2.34737849 |
| 10 | MP0002734_abnormal_mechanical_nocicepti | 2.32305609 |
| 11 | MP0006292_abnormal_olfactory_placode | 2.30415813 |
| 12 | MP0003122_maternal_imprinting | 2.28949192 |
| 13 | MP0002638_abnormal_pupillary_reflex | 2.21328170 |
| 14 | MP0002751_abnormal_autonomic_nervous | 2.16182504 |
| 15 | MP0003880_abnormal_central_pattern | 2.15849487 |
| 16 | MP0001984_abnormal_olfaction | 2.10205022 |
| 17 | MP0004270_analgesia | 2.07655081 |
| 18 | MP0008932_abnormal_embryonic_tissue | 2.01347526 |
| 19 | MP0001905_abnormal_dopamine_level | 2.01311930 |
| 20 | MP0005394_taste/olfaction_phenotype | 1.97267046 |
| 21 | MP0005499_abnormal_olfactory_system | 1.97267046 |
| 22 | MP0004957_abnormal_blastocyst_morpholog | 1.93311862 |
| 23 | MP0003329_amyloid_beta_deposits | 1.89476966 |
| 24 | MP0001486_abnormal_startle_reflex | 1.88366909 |
| 25 | MP0008058_abnormal_DNA_repair | 1.82150928 |
| 26 | MP0003787_abnormal_imprinting | 1.81826146 |
| 27 | MP0008260_abnormal_autophagy | 1.78847023 |
| 28 | MP0002733_abnormal_thermal_nociception | 1.78574320 |
| 29 | MP0002184_abnormal_innervation | 1.77331084 |
| 30 | MP0001970_abnormal_pain_threshold | 1.76900220 |
| 31 | MP0009379_abnormal_foot_pigmentation | 1.65023839 |
| 32 | MP0002160_abnormal_reproductive_system | 1.64424758 |
| 33 | MP0004858_abnormal_nervous_system | 1.63797135 |
| 34 | MP0004142_abnormal_muscle_tone | 1.62904905 |
| 35 | MP0006035_abnormal_mitochondrial_morpho | 1.57315928 |
| 36 | MP0004133_heterotaxia | 1.54137838 |
| 37 | MP0010386_abnormal_urinary_bladder | 1.52126968 |
| 38 | MP0003123_paternal_imprinting | 1.51867525 |
| 39 | MP0003315_abnormal_perineum_morphology | 1.50162257 |
| 40 | MP0003077_abnormal_cell_cycle | 1.48344972 |
| 41 | MP0008877_abnormal_DNA_methylation | 1.47583876 |
| 42 | MP0001188_hyperpigmentation | 1.45293630 |
| 43 | MP0003718_maternal_effect | 1.42048415 |
| 44 | MP0005645_abnormal_hypothalamus_physiol | 1.36938239 |
| 45 | MP0003646_muscle_fatigue | 1.36277888 |
| 46 | MP0000372_irregular_coat_pigmentation | 1.35350802 |
| 47 | MP0000015_abnormal_ear_pigmentation | 1.31925496 |
| 48 | MP0002272_abnormal_nervous_system | 1.31328613 |
| 49 | MP0004811_abnormal_neuron_physiology | 1.27886420 |
| 50 | MP0010030_abnormal_orbit_morphology | 1.27585073 |
| 51 | MP0000778_abnormal_nervous_system | 1.26463322 |
| 52 | MP0003121_genomic_imprinting | 1.25955840 |
| 53 | MP0003186_abnormal_redox_activity | 1.24261375 |
| 54 | MP0009046_muscle_twitch | 1.24049988 |
| 55 | MP0010094_abnormal_chromosome_stability | 1.23496235 |
| 56 | MP0002277_abnormal_respiratory_mucosa | 1.22689641 |
| 57 | MP0003635_abnormal_synaptic_transmissio | 1.18521072 |
| 58 | MP0004742_abnormal_vestibular_system | 1.17947576 |
| 59 | MP0002653_abnormal_ependyma_morphology | 1.17614729 |
| 60 | MP0008007_abnormal_cellular_replicative | 1.15371076 |
| 61 | MP0004859_abnormal_synaptic_plasticity | 1.14088238 |
| 62 | MP0002063_abnormal_learning/memory/cond | 1.13926783 |
| 63 | MP0002064_seizures | 1.13129044 |
| 64 | MP0003111_abnormal_nucleus_morphology | 1.12529780 |
| 65 | MP0002572_abnormal_emotion/affect_behav | 1.11733700 |
| 66 | MP0002234_abnormal_pharynx_morphology | 1.10363786 |
| 67 | MP0002229_neurodegeneration | 1.10032026 |
| 68 | MP0002148_abnormal_hypersensitivity_rea | 1.09664846 |
| 69 | MP0005646_abnormal_pituitary_gland | 1.08669475 |
| 70 | MP0000358_abnormal_cell_content/ | 1.08569461 |
| 71 | MP0000049_abnormal_middle_ear | 1.08288876 |
| 72 | MP0004885_abnormal_endolymph | 1.08075516 |
| 73 | MP0001502_abnormal_circadian_rhythm | 1.06443907 |
| 74 | MP0002557_abnormal_social/conspecific_i | 1.05510302 |
| 75 | MP0008569_lethality_at_weaning | 1.05057929 |
| 76 | MP0000920_abnormal_myelination | 1.03214483 |
| 77 | MP0002067_abnormal_sensory_capabilities | 1.02534267 |
| 78 | MP0005551_abnormal_eye_electrophysiolog | 1.02167538 |
| 79 | MP0009745_abnormal_behavioral_response | 1.01995846 |
| 80 | MP0006036_abnormal_mitochondrial_physio | 1.01518504 |
| 81 | MP0003806_abnormal_nucleotide_metabolis | 1.01152692 |
| 82 | MP0009333_abnormal_splenocyte_physiolog | 0.97396675 |
| 83 | MP0002938_white_spotting | 0.94938073 |
| 84 | MP0002102_abnormal_ear_morphology | 0.93957934 |
| 85 | MP0002152_abnormal_brain_morphology | 0.93849762 |
| 86 | MP0003137_abnormal_impulse_conducting | 0.93148471 |
| 87 | MP0001440_abnormal_grooming_behavior | 0.91994772 |
| 88 | MP0005423_abnormal_somatic_nervous | 0.91841357 |
| 89 | MP0004924_abnormal_behavior | 0.91648093 |
| 90 | MP0005386_behavior/neurological_phenoty | 0.91648093 |
| 91 | MP0002909_abnormal_adrenal_gland | 0.91472484 |
| 92 | MP0000681_abnormal_thyroid_gland | 0.91350865 |
| 93 | MP0005389_reproductive_system_phenotype | 0.91112517 |
| 94 | MP0002752_abnormal_somatic_nervous | 0.90513244 |
| 95 | MP0003011_delayed_dark_adaptation | 0.89875302 |
| 96 | MP0002132_abnormal_respiratory_system | 0.88335532 |
| 97 | MP0000604_amyloidosis | 0.87780730 |
| 98 | MP0002882_abnormal_neuron_morphology | 0.87435195 |
| 99 | MP0000750_abnormal_muscle_regeneration | 0.86892513 |
| 100 | MP0002163_abnormal_gland_morphology | 0.86209395 |
| 101 | MP0005253_abnormal_eye_physiology | 0.84490759 |
| 102 | MP0002876_abnormal_thyroid_physiology | 0.83961961 |
| 103 | MP0005084_abnormal_gallbladder_morpholo | 0.83877649 |
| 104 | MP0003633_abnormal_nervous_system | 0.83288057 |
| 105 | MP0002069_abnormal_eating/drinking_beha | 0.83278778 |
| 106 | MP0003136_yellow_coat_color | 0.83008429 |
| 107 | MP0001542_abnormal_bone_strength | 0.82664442 |
| 108 | MP0003879_abnormal_hair_cell | 0.76953345 |
| 109 | MP0003631_nervous_system_phenotype | 0.76046001 |
| 110 | MP0000639_abnormal_adrenal_gland | 0.75793997 |
| 111 | MP0006072_abnormal_retinal_apoptosis | 0.75782983 |
| 112 | MP0005410_abnormal_fertilization | 0.75112641 |
| 113 | MP0004147_increased_porphyrin_level | 0.74902095 |
| 114 | MP0000955_abnormal_spinal_cord | 0.74570815 |
| 115 | MP0003786_premature_aging | 0.74050582 |
| 116 | MP0003634_abnormal_glial_cell | 0.73124324 |
| 117 | MP0000538_abnormal_urinary_bladder | 0.73113848 |
| 118 | MP0000858_altered_metastatic_potential | 0.72792237 |
| 119 | MP0008875_abnormal_xenobiotic_pharmacok | 0.72735667 |
| 120 | MP0003941_abnormal_skin_development | 0.72307140 |
| 121 | MP0003938_abnormal_ear_development | 0.69328593 |
| 122 | MP0001501_abnormal_sleep_pattern | 0.69135933 |
| 123 | MP0000026_abnormal_inner_ear | 0.68432501 |
| 124 | MP0002332_abnormal_exercise_endurance | 0.67980825 |
| 125 | MP0001963_abnormal_hearing_physiology | 0.67369168 |
| 126 | MP0002066_abnormal_motor_capabilities/c | 0.66815973 |
| 127 | MP0003942_abnormal_urinary_system | 0.65180964 |
| 128 | MP0000631_abnormal_neuroendocrine_gland | 0.64842325 |
| 129 | MP0005367_renal/urinary_system_phenotyp | 0.64298446 |
| 130 | MP0000516_abnormal_urinary_system | 0.64298446 |
| 131 | MP0002837_dystrophic_cardiac_calcinosis | 0.63425735 |
| 132 | MP0008872_abnormal_physiological_respon | 0.62912632 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 6.12928138 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.57686401 |
| 3 | Mitochondrial inheritance (HP:0001427) | 5.16176340 |
| 4 | Progressive macrocephaly (HP:0004481) | 4.96028362 |
| 5 | Increased CSF lactate (HP:0002490) | 4.51354908 |
| 6 | Acute encephalopathy (HP:0006846) | 4.48893204 |
| 7 | Hepatocellular necrosis (HP:0001404) | 4.40863475 |
| 8 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.70726755 |
| 9 | Hepatic necrosis (HP:0002605) | 3.60948866 |
| 10 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.60054967 |
| 11 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.60054967 |
| 12 | Myokymia (HP:0002411) | 3.59958661 |
| 13 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.49271635 |
| 14 | Abnormality of glycolysis (HP:0004366) | 3.39005064 |
| 15 | Increased serum pyruvate (HP:0003542) | 3.39005064 |
| 16 | Increased hepatocellular lipid droplets (HP:0006565) | 3.37352582 |
| 17 | Increased serum lactate (HP:0002151) | 3.25191969 |
| 18 | Amyotrophic lateral sclerosis (HP:0007354) | 3.24661380 |
| 19 | Exercise intolerance (HP:0003546) | 3.18197953 |
| 20 | Respiratory failure (HP:0002878) | 3.10649233 |
| 21 | Cerebral hypomyelination (HP:0006808) | 3.01559146 |
| 22 | Optic disc pallor (HP:0000543) | 2.96458233 |
| 23 | Lactic acidosis (HP:0003128) | 2.91668664 |
| 24 | 3-Methylglutaconic aciduria (HP:0003535) | 2.84306313 |
| 25 | Lipid accumulation in hepatocytes (HP:0006561) | 2.81490748 |
| 26 | Neuroendocrine neoplasm (HP:0100634) | 2.79995608 |
| 27 | Leukodystrophy (HP:0002415) | 2.77033830 |
| 28 | Poor suck (HP:0002033) | 2.76251457 |
| 29 | Degeneration of anterior horn cells (HP:0002398) | 2.74744016 |
| 30 | Abnormality of the anterior horn cell (HP:0006802) | 2.74744016 |
| 31 | Pheochromocytoma (HP:0002666) | 2.73666966 |
| 32 | Renal Fanconi syndrome (HP:0001994) | 2.67629048 |
| 33 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.65222001 |
| 34 | Limb dystonia (HP:0002451) | 2.58420844 |
| 35 | Focal motor seizures (HP:0011153) | 2.57506512 |
| 36 | Exertional dyspnea (HP:0002875) | 2.53287057 |
| 37 | Type I transferrin isoform profile (HP:0003642) | 2.50492999 |
| 38 | Cerebral edema (HP:0002181) | 2.48427266 |
| 39 | Pancreatic fibrosis (HP:0100732) | 2.47754702 |
| 40 | Microretrognathia (HP:0000308) | 2.45445688 |
| 41 | Hypothermia (HP:0002045) | 2.44203928 |
| 42 | Progressive microcephaly (HP:0000253) | 2.42880209 |
| 43 | Microvesicular hepatic steatosis (HP:0001414) | 2.40095229 |
| 44 | Rough bone trabeculation (HP:0100670) | 2.39932793 |
| 45 | Gait imbalance (HP:0002141) | 2.38651774 |
| 46 | Increased intramyocellular lipid droplets (HP:0012240) | 2.38478785 |
| 47 | Abnormal number of erythroid precursors (HP:0012131) | 2.37568130 |
| 48 | Medial flaring of the eyebrow (HP:0010747) | 2.37140655 |
| 49 | Birth length less than 3rd percentile (HP:0003561) | 2.33834288 |
| 50 | Abnormal neuron morphology (HP:0012757) | 2.33497414 |
| 51 | Abnormality of the motor neurons (HP:0002450) | 2.33497414 |
| 52 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.30808611 |
| 53 | Hypoplasia of the brainstem (HP:0002365) | 2.29235538 |
| 54 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.29235538 |
| 55 | True hermaphroditism (HP:0010459) | 2.28222533 |
| 56 | Mutism (HP:0002300) | 2.28082877 |
| 57 | Congenital primary aphakia (HP:0007707) | 2.27644511 |
| 58 | Nephrogenic diabetes insipidus (HP:0009806) | 2.26947096 |
| 59 | Carpal bone hypoplasia (HP:0001498) | 2.26926949 |
| 60 | Failure to thrive in infancy (HP:0001531) | 2.26519482 |
| 61 | Ankle clonus (HP:0011448) | 2.26517316 |
| 62 | Abnormal hair whorl (HP:0010721) | 2.26346399 |
| 63 | Breast hypoplasia (HP:0003187) | 2.26283216 |
| 64 | Irregular epiphyses (HP:0010582) | 2.24405925 |
| 65 | Focal seizures (HP:0007359) | 2.23818916 |
| 66 | Emotional lability (HP:0000712) | 2.22419231 |
| 67 | Amblyopia (HP:0000646) | 2.22004045 |
| 68 | Supranuclear gaze palsy (HP:0000605) | 2.20691450 |
| 69 | Pancreatic cysts (HP:0001737) | 2.20572136 |
| 70 | Opisthotonus (HP:0002179) | 2.19972061 |
| 71 | Visual hallucinations (HP:0002367) | 2.19961549 |
| 72 | Respiratory difficulties (HP:0002880) | 2.19709916 |
| 73 | Reticulocytopenia (HP:0001896) | 2.12662674 |
| 74 | Patellar aplasia (HP:0006443) | 2.11013139 |
| 75 | Delusions (HP:0000746) | 2.06965421 |
| 76 | Abnormal eating behavior (HP:0100738) | 2.06514997 |
| 77 | Tongue fasciculations (HP:0001308) | 2.04842706 |
| 78 | X-linked dominant inheritance (HP:0001423) | 2.03514021 |
| 79 | Split foot (HP:0001839) | 2.00751680 |
| 80 | Aplastic anemia (HP:0001915) | 1.97918966 |
| 81 | Polyphagia (HP:0002591) | 1.94912009 |
| 82 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.94874623 |
| 83 | Focal dystonia (HP:0004373) | 1.94331582 |
| 84 | Ragged-red muscle fibers (HP:0003200) | 1.92185901 |
| 85 | Epileptic encephalopathy (HP:0200134) | 1.90491543 |
| 86 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.90027453 |
| 87 | Gliosis (HP:0002171) | 1.89754044 |
| 88 | Facial cleft (HP:0002006) | 1.89286273 |
| 89 | Genital tract atresia (HP:0001827) | 1.88203682 |
| 90 | Optic nerve coloboma (HP:0000588) | 1.87779592 |
| 91 | Vaginal atresia (HP:0000148) | 1.86784491 |
| 92 | Lissencephaly (HP:0001339) | 1.86468189 |
| 93 | Craniofacial dystonia (HP:0012179) | 1.86409570 |
| 94 | Abnormality of the labia minora (HP:0012880) | 1.86336161 |
| 95 | CNS demyelination (HP:0007305) | 1.85743745 |
| 96 | Muscular hypotonia of the trunk (HP:0008936) | 1.85517140 |
| 97 | Severe visual impairment (HP:0001141) | 1.84474425 |
| 98 | Spastic gait (HP:0002064) | 1.84088730 |
| 99 | Abnormal trabecular bone morphology (HP:0100671) | 1.83757905 |
| 100 | Unsteady gait (HP:0002317) | 1.82266384 |
| 101 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.82201049 |
| 102 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.81557962 |
| 103 | Delayed CNS myelination (HP:0002188) | 1.81273538 |
| 104 | Abnormality of the vocal cords (HP:0008777) | 1.80842682 |
| 105 | Molar tooth sign on MRI (HP:0002419) | 1.80027660 |
| 106 | Abnormality of midbrain morphology (HP:0002418) | 1.80027660 |
| 107 | Hydroureter (HP:0000072) | 1.79698466 |
| 108 | Upper limb muscle weakness (HP:0003484) | 1.79684458 |
| 109 | Oral leukoplakia (HP:0002745) | 1.79509664 |
| 110 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.79089930 |
| 111 | Sclerocornea (HP:0000647) | 1.77979733 |
| 112 | Esotropia (HP:0000565) | 1.77257580 |
| 113 | Torticollis (HP:0000473) | 1.76432202 |
| 114 | Spastic tetraplegia (HP:0002510) | 1.75448002 |
| 115 | Increased muscle lipid content (HP:0009058) | 1.75111582 |
| 116 | Methylmalonic aciduria (HP:0012120) | 1.75001073 |
| 117 | Peripheral hypomyelination (HP:0007182) | 1.73416051 |
| 118 | Lethargy (HP:0001254) | 1.72730735 |
| 119 | Agitation (HP:0000713) | 1.71798682 |
| 120 | Premature graying of hair (HP:0002216) | 1.71180435 |
| 121 | Muscle fibrillation (HP:0010546) | 1.71071843 |
| 122 | Anomalous pulmonary venous return (HP:0010772) | 1.70966710 |
| 123 | Abnormality of magnesium homeostasis (HP:0004921) | 1.70097867 |
| 124 | Abnormality of the lower motor neuron (HP:0002366) | 1.69259070 |
| 125 | Abnormality of the corticospinal tract (HP:0002492) | 1.68280482 |
| 126 | Hypsarrhythmia (HP:0002521) | 1.67896130 |
| 127 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.67618288 |
| 128 | Blindness (HP:0000618) | 1.67448490 |
| 129 | Epileptiform EEG discharges (HP:0011182) | 1.67149237 |
| 130 | Pachygyria (HP:0001302) | 1.66638821 |
| 131 | Hypokinesia (HP:0002375) | 1.66618514 |
| 132 | Cerebral palsy (HP:0100021) | 1.66400626 |
| 133 | Cleft eyelid (HP:0000625) | 1.66204923 |
| 134 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.66097946 |
| 135 | Pallor (HP:0000980) | 1.65018252 |
| 136 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.64842072 |
| 137 | Macrocytic anemia (HP:0001972) | 1.64199016 |
| 138 | Poor head control (HP:0002421) | 1.62533986 |
| 139 | Retinal dysplasia (HP:0007973) | 1.62049910 |
| 140 | Short tibia (HP:0005736) | 1.61747534 |
| 141 | Type 2 muscle fiber atrophy (HP:0003554) | 1.61644237 |
| 142 | Palpitations (HP:0001962) | 1.61432610 |
| 143 | Abnormal lung lobation (HP:0002101) | 1.61305517 |
| 144 | Bifid tongue (HP:0010297) | 1.61039234 |
| 145 | CNS hypomyelination (HP:0003429) | 1.60987941 |
| 146 | Cellular immunodeficiency (HP:0005374) | 1.60323105 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.29303782 |
| 2 | ARAF | 3.52143970 |
| 3 | VRK2 | 3.22136309 |
| 4 | STK16 | 3.17093009 |
| 5 | BCKDK | 3.12219080 |
| 6 | CASK | 2.93014760 |
| 7 | PIM2 | 2.69495181 |
| 8 | TESK2 | 2.63805863 |
| 9 | TESK1 | 2.62339705 |
| 10 | LIMK1 | 2.58009718 |
| 11 | NME2 | 2.47303102 |
| 12 | BRAF | 2.28844637 |
| 13 | MAP3K12 | 2.23043850 |
| 14 | MARK1 | 2.22884756 |
| 15 | DYRK2 | 2.22848814 |
| 16 | EIF2AK1 | 1.99225701 |
| 17 | MAP4K2 | 1.93115091 |
| 18 | NME1 | 1.91825384 |
| 19 | CSNK1G2 | 1.90611861 |
| 20 | VRK1 | 1.90589696 |
| 21 | CSNK1A1L | 1.86988805 |
| 22 | PLK4 | 1.83263148 |
| 23 | EPHA4 | 1.79030586 |
| 24 | PAK6 | 1.70166455 |
| 25 | SRPK1 | 1.66770184 |
| 26 | TLK1 | 1.66697122 |
| 27 | EIF2AK3 | 1.62334456 |
| 28 | MAP2K7 | 1.57640403 |
| 29 | NEK1 | 1.52283739 |
| 30 | MINK1 | 1.49212441 |
| 31 | ERBB3 | 1.48062398 |
| 32 | WEE1 | 1.47840947 |
| 33 | PBK | 1.47188467 |
| 34 | MAPK13 | 1.44777763 |
| 35 | SIK3 | 1.44072157 |
| 36 | CSNK1G1 | 1.44058167 |
| 37 | BCR | 1.35770889 |
| 38 | PLK2 | 1.34458405 |
| 39 | DAPK2 | 1.32783147 |
| 40 | TSSK6 | 1.32498309 |
| 41 | CDK19 | 1.30213447 |
| 42 | AURKA | 1.18924164 |
| 43 | TRIM28 | 1.18826306 |
| 44 | YES1 | 1.12978423 |
| 45 | PRKD3 | 1.09983452 |
| 46 | PLK3 | 1.09651736 |
| 47 | GRK5 | 1.09061411 |
| 48 | NTRK2 | 1.07752725 |
| 49 | DAPK1 | 1.02575790 |
| 50 | DYRK3 | 1.00903569 |
| 51 | IRAK4 | 0.98312673 |
| 52 | CCNB1 | 0.97124410 |
| 53 | BMPR2 | 0.95122943 |
| 54 | PKN1 | 0.92891448 |
| 55 | AKT3 | 0.90288271 |
| 56 | MYLK | 0.89891683 |
| 57 | ZAK | 0.89124297 |
| 58 | MAP2K4 | 0.88924481 |
| 59 | ABL2 | 0.86125383 |
| 60 | BRSK1 | 0.84842946 |
| 61 | CDK14 | 0.83259230 |
| 62 | PINK1 | 0.82600335 |
| 63 | BLK | 0.82310979 |
| 64 | MKNK1 | 0.81970569 |
| 65 | STK24 | 0.80572578 |
| 66 | ADRBK2 | 0.80422209 |
| 67 | CAMKK1 | 0.80065186 |
| 68 | PRKCI | 0.79421267 |
| 69 | CDK18 | 0.78429047 |
| 70 | ACVR1B | 0.76775811 |
| 71 | ILK | 0.76329814 |
| 72 | UHMK1 | 0.75901117 |
| 73 | PLK1 | 0.74789895 |
| 74 | DAPK3 | 0.73209873 |
| 75 | CDK5 | 0.73170032 |
| 76 | BMPR1B | 0.72680744 |
| 77 | CDC7 | 0.71350787 |
| 78 | GRK7 | 0.69028510 |
| 79 | SIK2 | 0.68936939 |
| 80 | MST4 | 0.67002662 |
| 81 | CDK15 | 0.66576724 |
| 82 | STK38L | 0.66375441 |
| 83 | DYRK1B | 0.65379711 |
| 84 | CDK11A | 0.64134014 |
| 85 | PHKG1 | 0.63785510 |
| 86 | PHKG2 | 0.63785510 |
| 87 | PRPF4B | 0.63503477 |
| 88 | CAMK2A | 0.62846769 |
| 89 | * PAK1 | 0.60938591 |
| 90 | MAPKAPK3 | 0.60885316 |
| 91 | TAOK2 | 0.60448198 |
| 92 | LMTK2 | 0.60033617 |
| 93 | MAP3K4 | 0.59001284 |
| 94 | EIF2AK2 | 0.56961026 |
| 95 | CSNK2A1 | 0.55492800 |
| 96 | PRKCG | 0.54653623 |
| 97 | RPS6KA2 | 0.54276491 |
| 98 | NTRK1 | 0.53439876 |
| 99 | ADRBK1 | 0.50656580 |
| 100 | WNK3 | 0.50209693 |
| 101 | LATS2 | 0.49800075 |
| 102 | CAMK2G | 0.49230531 |
| 103 | CAMK2B | 0.44383367 |
| 104 | MAP3K11 | 0.44034652 |
| 105 | CSNK1G3 | 0.43961370 |
| 106 | NTRK3 | 0.43864319 |
| 107 | GRK6 | 0.42546022 |
| 108 | BRSK2 | 0.42177810 |
| 109 | MAP3K5 | 0.41676097 |
| 110 | CAMKK2 | 0.41453355 |
| 111 | PAK3 | 0.40627161 |
| 112 | RPS6KL1 | 0.39955276 |
| 113 | RPS6KC1 | 0.39955276 |
| 114 | RPS6KA5 | 0.39711094 |
| 115 | EPHB2 | 0.38474899 |
| 116 | MAPKAPK5 | 0.38114149 |
| 117 | AURKB | 0.38030393 |
| 118 | CSNK2A2 | 0.37757740 |
| 119 | FES | 0.37545045 |
| 120 | DYRK1A | 0.36959815 |
| 121 | CSNK1A1 | 0.35613511 |
| 122 | PAK4 | 0.33641660 |
| 123 | PASK | 0.33595579 |
| 124 | RAF1 | 0.32963449 |
| 125 | RPS6KA4 | 0.32873665 |
| 126 | KDR | 0.32785747 |
| 127 | SCYL2 | 0.32657682 |
| 128 | CDK8 | 0.31947916 |
| 129 | CAMK2D | 0.31585389 |
| 130 | CHEK2 | 0.30263915 |
| 131 | RPS6KA6 | 0.28777255 |
| 132 | PRKACA | 0.26559114 |
| 133 | PRKCZ | 0.25618525 |
| 134 | ATR | 0.25347075 |
| 135 | PRKCA | 0.22661032 |
| 136 | PRKD1 | 0.21920756 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.33252185 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.54802355 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 4.02446329 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.64788730 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 3.33364240 |
| 6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.07301648 |
| 7 | Alzheimers disease_Homo sapiens_hsa05010 | 2.73657521 |
| 8 | DNA replication_Homo sapiens_hsa03030 | 2.48906359 |
| 9 | Protein export_Homo sapiens_hsa03060 | 2.38126862 |
| 10 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.22125072 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.21827086 |
| 12 | Mismatch repair_Homo sapiens_hsa03430 | 2.21469442 |
| 13 | Spliceosome_Homo sapiens_hsa03040 | 2.08355675 |
| 14 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.01021061 |
| 15 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.90975969 |
| 16 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.87468229 |
| 17 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.81291785 |
| 18 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.75904630 |
| 19 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.71177316 |
| 20 | Base excision repair_Homo sapiens_hsa03410 | 1.66832445 |
| 21 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.65683972 |
| 22 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.59695945 |
| 23 | RNA transport_Homo sapiens_hsa03013 | 1.55354057 |
| 24 | Basal transcription factors_Homo sapiens_hsa03022 | 1.45771105 |
| 25 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 1.39184776 |
| 26 | Homologous recombination_Homo sapiens_hsa03440 | 1.35168649 |
| 27 | Purine metabolism_Homo sapiens_hsa00230 | 1.30492030 |
| 28 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.28665415 |
| 29 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.25862660 |
| 30 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.24727264 |
| 31 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.19560453 |
| 32 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.17941871 |
| 33 | Phagosome_Homo sapiens_hsa04145 | 1.08064960 |
| 34 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.06880236 |
| 35 | Cell cycle_Homo sapiens_hsa04110 | 1.06647798 |
| 36 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.05968545 |
| 37 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.00731321 |
| 38 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.00003539 |
| 39 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.99569920 |
| 40 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.95891364 |
| 41 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.95769314 |
| 42 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.93001370 |
| 43 | RNA degradation_Homo sapiens_hsa03018 | 0.92575361 |
| 44 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.90018342 |
| 45 | Circadian entrainment_Homo sapiens_hsa04713 | 0.87726219 |
| 46 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.84731268 |
| 47 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.82076229 |
| 48 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.79462876 |
| 49 | Peroxisome_Homo sapiens_hsa04146 | 0.76947769 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.74715279 |
| 51 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.74302070 |
| 52 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.73713531 |
| 53 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.72898718 |
| 54 | Legionellosis_Homo sapiens_hsa05134 | 0.71829953 |
| 55 | Cocaine addiction_Homo sapiens_hsa05030 | 0.71039952 |
| 56 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.69982206 |
| 57 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.68204510 |
| 58 | Asthma_Homo sapiens_hsa05310 | 0.63958719 |
| 59 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.63817137 |
| 60 | Olfactory transduction_Homo sapiens_hsa04740 | 0.61935701 |
| 61 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.61512322 |
| 62 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.61215542 |
| 63 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.60523880 |
| 64 | Phototransduction_Homo sapiens_hsa04744 | 0.58367506 |
| 65 | Shigellosis_Homo sapiens_hsa05131 | 0.56282862 |
| 66 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.55639784 |
| 67 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.54918675 |
| 68 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.54566211 |
| 69 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.53553292 |
| 70 | Alcoholism_Homo sapiens_hsa05034 | 0.53245611 |
| 71 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.53023245 |
| 72 | One carbon pool by folate_Homo sapiens_hsa00670 | 0.52673305 |
| 73 | Nicotine addiction_Homo sapiens_hsa05033 | 0.51530615 |
| 74 | Salmonella infection_Homo sapiens_hsa05132 | 0.49447069 |
| 75 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.47737770 |
| 76 | Metabolic pathways_Homo sapiens_hsa01100 | 0.47350550 |
| 77 | Allograft rejection_Homo sapiens_hsa05330 | 0.47024035 |
| 78 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.45915970 |
| 79 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.44102842 |
| 80 | Axon guidance_Homo sapiens_hsa04360 | 0.42688736 |
| 81 | Endocytosis_Homo sapiens_hsa04144 | 0.42641315 |
| 82 | Salivary secretion_Homo sapiens_hsa04970 | 0.40656489 |
| 83 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.40373838 |
| 84 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.40111362 |
| 85 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.39542534 |
| 86 | Insulin secretion_Homo sapiens_hsa04911 | 0.39226252 |
| 87 | Taste transduction_Homo sapiens_hsa04742 | 0.38761603 |
| 88 | Thyroid cancer_Homo sapiens_hsa05216 | 0.38730849 |
| 89 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.38525181 |
| 90 | Galactose metabolism_Homo sapiens_hsa00052 | 0.38307309 |
| 91 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.37776406 |
| 92 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.36880073 |
| 93 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.36106796 |
| 94 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.35768031 |
| 95 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.34883173 |
| 96 | Sulfur relay system_Homo sapiens_hsa04122 | 0.34759449 |
| 97 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.34593114 |
| 98 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.33938689 |
| 99 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.33500878 |
| 100 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.32493986 |
| 101 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.31557402 |
| 102 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.31016640 |
| 103 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.29435580 |
| 104 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.25117729 |
| 105 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.24533302 |
| 106 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.24055008 |
| 107 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.22165932 |
| 108 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.22031040 |
| 109 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.21854131 |
| 110 | Viral myocarditis_Homo sapiens_hsa05416 | 0.21658932 |
| 111 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.21613791 |
| 112 | Pertussis_Homo sapiens_hsa05133 | 0.21517735 |
| 113 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.20776297 |
| 114 | Tuberculosis_Homo sapiens_hsa05152 | 0.19892640 |
| 115 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.17786997 |
| 116 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.17702591 |
| 117 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.16989563 |
| 118 | Gap junction_Homo sapiens_hsa04540 | 0.16463455 |
| 119 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.16163545 |
| 120 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.16142900 |
| 121 | Melanoma_Homo sapiens_hsa05218 | 0.15930982 |
| 122 | Apoptosis_Homo sapiens_hsa04210 | 0.15728143 |
| 123 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.15296287 |
| 124 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.14728112 |
| 125 | Morphine addiction_Homo sapiens_hsa05032 | 0.14336894 |
| 126 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.14038145 |
| 127 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.13508457 |
| 128 | Carbon metabolism_Homo sapiens_hsa01200 | 0.12272645 |
| 129 | GABAergic synapse_Homo sapiens_hsa04727 | 0.11752680 |
| 130 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.11224662 |
| 131 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.10778304 |

