TBCB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.73931122
2ATP synthesis coupled proton transport (GO:0015986)5.42875598
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.42875598
4cullin deneddylation (GO:0010388)4.85122176
5protein neddylation (GO:0045116)4.76312655
6chaperone-mediated protein transport (GO:0072321)4.73550278
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.67703807
8protein deneddylation (GO:0000338)4.57743390
9proteasome assembly (GO:0043248)4.48475114
10pyrimidine nucleobase catabolic process (GO:0006208)4.45177500
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.42492633
12sequestering of actin monomers (GO:0042989)4.32315887
13positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.27292911
14synaptic vesicle exocytosis (GO:0016079)4.24103687
15regulation of cellular amino acid metabolic process (GO:0006521)4.23736516
16negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.22977743
17negative regulation of ligase activity (GO:0051352)4.22977743
18establishment of mitochondrion localization (GO:0051654)4.19502587
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.16696869
20regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.15002804
21protein maturation by protein folding (GO:0022417)4.11683474
22protein complex biogenesis (GO:0070271)4.11571079
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.07477239
24signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.07477239
25respiratory electron transport chain (GO:0022904)4.07475772
26signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.06028147
27signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.06028147
28signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.06028147
29DNA deamination (GO:0045006)4.01876903
302-deoxyribonucleotide biosynthetic process (GO:0009265)4.00912347
31deoxyribose phosphate biosynthetic process (GO:0046385)4.00912347
32anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.99509126
33electron transport chain (GO:0022900)3.98946748
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.98895875
35signal transduction involved in cell cycle checkpoint (GO:0072395)3.96550624
36signal transduction involved in DNA integrity checkpoint (GO:0072401)3.95640522
37signal transduction involved in DNA damage checkpoint (GO:0072422)3.95640522
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.84024967
39termination of RNA polymerase III transcription (GO:0006386)3.84024967
40mitochondrial respiratory chain complex assembly (GO:0033108)3.82726285
41antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.80021943
42positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.78760201
43mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.78385616
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.78385616
45NADH dehydrogenase complex assembly (GO:0010257)3.78385616
46synaptic vesicle maturation (GO:0016188)3.78271443
47pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.77422388
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.77156571
49regulation of mitochondrial translation (GO:0070129)3.62711883
50positive regulation of ligase activity (GO:0051351)3.61068527
51oxidative phosphorylation (GO:0006119)3.58889303
527-methylguanosine mRNA capping (GO:0006370)3.57342968
53nucleobase-containing small molecule interconversion (GO:0015949)3.55000624
54guanosine-containing compound biosynthetic process (GO:1901070)3.54933795
55deoxyribonucleotide biosynthetic process (GO:0009263)3.53425675
56de novo posttranslational protein folding (GO:0051084)3.52646953
57base-excision repair, AP site formation (GO:0006285)3.50801099
58protein targeting to mitochondrion (GO:0006626)3.50188489
59RNA capping (GO:0036260)3.49744918
607-methylguanosine RNA capping (GO:0009452)3.49744918
61establishment of protein localization to mitochondrion (GO:0072655)3.49718145
62de novo protein folding (GO:0006458)3.48931296
63peptidyl-arginine omega-N-methylation (GO:0035247)3.46457814
64establishment of integrated proviral latency (GO:0075713)3.40717795
65ATP hydrolysis coupled proton transport (GO:0015991)3.39110716
66energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.39110716
67formation of translation preinitiation complex (GO:0001731)3.38326063
68positive regulation of mitochondrial fission (GO:0090141)3.36525637
69maturation of SSU-rRNA (GO:0030490)3.33268805
70glutamate secretion (GO:0014047)3.32456136
71tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.31427127
72RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.31427127
73cytochrome complex assembly (GO:0017004)3.29380702
74spliceosomal snRNP assembly (GO:0000387)3.28601247
75pyrimidine nucleotide catabolic process (GO:0006244)3.28266064
76regulation of ubiquitin-protein transferase activity (GO:0051438)3.28063636
77nucleobase catabolic process (GO:0046113)3.27536840
78GTP biosynthetic process (GO:0006183)3.26512167
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.23769458
80negative regulation of synaptic transmission, GABAergic (GO:0032229)3.23714400
81protein localization to synapse (GO:0035418)3.23650428
82lipopolysaccharide biosynthetic process (GO:0009103)3.23437437
83negative regulation of microtubule polymerization (GO:0031115)3.23124487
84establishment of protein localization to mitochondrial membrane (GO:0090151)3.22170663
85ribosomal small subunit assembly (GO:0000028)3.21014719
86deoxyribonucleoside diphosphate metabolic process (GO:0009186)3.19942495
87positive regulation of cell cycle arrest (GO:0071158)3.17925426
88protein localization to mitochondrion (GO:0070585)3.17075323
89regulation of cellular amine metabolic process (GO:0033238)3.16430360
90regulation of synapse structural plasticity (GO:0051823)3.16015094
91regulation of ligase activity (GO:0051340)3.15433751
92protein polyglutamylation (GO:0018095)3.13245201
93respiratory chain complex IV assembly (GO:0008535)3.12704181
94DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.10314613
95ribosomal small subunit biogenesis (GO:0042274)3.09834104
96histone arginine methylation (GO:0034969)3.06667338
97gamma-aminobutyric acid transport (GO:0015812)3.05502299
98translation (GO:0006412)3.05082490
99pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.03140907
100postsynaptic membrane organization (GO:0001941)2.99091709
101positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.98699846
102antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.98648293
103establishment of viral latency (GO:0019043)2.98196041
104metallo-sulfur cluster assembly (GO:0031163)2.98094600
105iron-sulfur cluster assembly (GO:0016226)2.98094600
106protein-cofactor linkage (GO:0018065)2.97770913
107viral transcription (GO:0019083)2.96968971
108platelet dense granule organization (GO:0060155)2.96177662
109peptidyl-arginine N-methylation (GO:0035246)2.96073640
110peptidyl-arginine methylation (GO:0018216)2.96073640
111deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.95224117
112establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.94427975
113mitochondrion transport along microtubule (GO:0047497)2.94427975
114neuron cell-cell adhesion (GO:0007158)2.93460395
115SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91688515
116GDP-mannose metabolic process (GO:0019673)2.91163020
117negative regulation of cell cycle G1/S phase transition (GO:1902807)2.89618841
118negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.89618841
119deoxyribonucleotide catabolic process (GO:0009264)2.89411393
120protein targeting to ER (GO:0045047)2.88606171
121purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.88538138
122cellular component biogenesis (GO:0044085)2.88441907
123mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.88397489
124cotranslational protein targeting to membrane (GO:0006613)2.88082885
125translational termination (GO:0006415)2.87355752
126protein insertion into membrane (GO:0051205)2.86631720
1272-deoxyribonucleotide metabolic process (GO:0009394)2.85377541
128UTP biosynthetic process (GO:0006228)2.84909511
129hydrogen ion transmembrane transport (GO:1902600)2.84472574
130purine nucleoside triphosphate biosynthetic process (GO:0009145)2.83905465
131transcription-coupled nucleotide-excision repair (GO:0006283)2.81837188
132viral mRNA export from host cell nucleus (GO:0046784)2.81727900
133negative regulation of protein ubiquitination (GO:0031397)2.80541227
134purine deoxyribonucleotide metabolic process (GO:0009151)2.79966129
135positive regulation of TOR signaling (GO:0032008)2.74919337
136ATP biosynthetic process (GO:0006754)2.67441103
137regulation of cellular respiration (GO:0043457)2.66934612
138regulation of short-term neuronal synaptic plasticity (GO:0048172)2.66827065
139neurotransmitter secretion (GO:0007269)2.65622909
140positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.65147487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.70663979
2* JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.21735299
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.13673751
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.92895813
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.80129767
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.66782908
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.61319498
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.59422152
9* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49489308
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.48258688
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.37260102
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.07623799
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.03963020
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97488080
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81495958
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.73041108
17YY1_21170310_ChIP-Seq_MESCs_Mouse2.59631306
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51518093
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50495143
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43055779
21E2F7_22180533_ChIP-Seq_HELA_Human2.41643938
22XRN2_22483619_ChIP-Seq_HELA_Human2.39590516
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38283209
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.35047284
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.32551344
26DCP1A_22483619_ChIP-Seq_HELA_Human2.31049198
27* VDR_23849224_ChIP-Seq_CD4+_Human2.30527358
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.23264805
29GABP_19822575_ChIP-Seq_HepG2_Human2.13421005
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13253305
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.01882686
32TTF2_22483619_ChIP-Seq_HELA_Human1.97776441
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94853842
34FOXP3_21729870_ChIP-Seq_TREG_Human1.76467255
35* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.75841520
36ELK1_19687146_ChIP-ChIP_HELA_Human1.74694437
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.69835032
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67299206
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66552542
40POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.64851988
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62835697
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62741056
43SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.62295192
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.61416483
45REST_18959480_ChIP-ChIP_MESCs_Mouse1.60819774
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53773216
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51462437
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51056036
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50789907
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.49256738
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47538244
52BCL6_27268052_Chip-Seq_Bcells_Human1.46249079
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44138068
54DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43738439
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42470647
56ELK1_22589737_ChIP-Seq_MCF10A_Human1.42095360
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39186900
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37597436
59REST_21632747_ChIP-Seq_MESCs_Mouse1.37394788
60YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35780308
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35343833
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33936072
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33430930
64P68_20966046_ChIP-Seq_HELA_Human1.33223945
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.32883775
66* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30884305
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29312081
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28902547
69* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27088976
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26976062
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26065016
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24762641
73CTCF_20526341_ChIP-Seq_ESCs_Human1.24050484
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23414831
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22789925
76SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.22573736
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21242726
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19526216
79CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18750313
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18460985
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17196979
82MYC_18940864_ChIP-ChIP_HL60_Human1.15342924
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15336022
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13248666
85* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12611133
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12079460
87CTCF_26484167_Chip-Seq_Bcells_Mouse1.11729562
88CIITA_25753668_ChIP-Seq_RAJI_Human1.11494751
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11265003
90PHF8_20622854_ChIP-Seq_HELA_Human1.10522715
91LXR_22292898_ChIP-Seq_THP-1_Human1.10158364
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.08642296
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08092044
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07304581
95CTCF_27219007_Chip-Seq_Bcells_Human1.06687743
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06461605
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06240263
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05480584
99OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03975755
100EZH2_27294783_Chip-Seq_ESCs_Mouse1.03830260
101VDR_22108803_ChIP-Seq_LS180_Human1.03707494
102IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03654769
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02915924
104EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.01038240
105BCOR_27268052_Chip-Seq_Bcells_Human1.00911236
106E2F1_20622854_ChIP-Seq_HELA_Human1.00774486
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98323393
108EED_16625203_ChIP-ChIP_MESCs_Mouse0.98152479
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97408335
110SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95655862
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95458377
112ZNF274_21170338_ChIP-Seq_K562_Hela0.94190448
113ERG_21242973_ChIP-ChIP_JURKAT_Human0.94064076
114BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93470925
115RARB_27405468_Chip-Seq_BRAIN_Mouse0.93358596
116SA1_27219007_Chip-Seq_ERYTHROID_Human0.93144904
117ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92462452
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92342459
119SA1_27219007_Chip-Seq_Bcells_Human0.92311835
120* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90267698
121PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90164860
122SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89374769
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89154389
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88984001
125SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88783605
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88432090
127* RARB_24833708_ChIP-Seq_LIVER_Mouse0.87343511
128EZH2_22144423_ChIP-Seq_EOC_Human0.84180701
129PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84170601
130TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83076803
131KDM5A_27292631_Chip-Seq_BREAST_Human0.82552853
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82265204
133NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81538091
134RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.79949297
135FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76845919
136TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.72122016
137TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.71160183
138* FOXP1_21924763_ChIP-Seq_HESCs_Human0.70574988
139NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.69630879
140NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.68330757

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy3.29638548
2MP0006276_abnormal_autonomic_nervous3.06597918
3MP0002735_abnormal_chemical_nociception2.74714884
4MP0001986_abnormal_taste_sensitivity2.70281747
5MP0003693_abnormal_embryo_hatching2.63999171
6MP0001968_abnormal_touch/_nociception2.59178477
7MP0002736_abnormal_nociception_after2.55284779
8MP0001529_abnormal_vocalization2.50016708
9MP0008789_abnormal_olfactory_epithelium2.34737849
10MP0002734_abnormal_mechanical_nocicepti2.32305609
11MP0006292_abnormal_olfactory_placode2.30415813
12MP0003122_maternal_imprinting2.28949192
13MP0002638_abnormal_pupillary_reflex2.21328170
14MP0002751_abnormal_autonomic_nervous2.16182504
15MP0003880_abnormal_central_pattern2.15849487
16MP0001984_abnormal_olfaction2.10205022
17MP0004270_analgesia2.07655081
18MP0008932_abnormal_embryonic_tissue2.01347526
19MP0001905_abnormal_dopamine_level2.01311930
20MP0005394_taste/olfaction_phenotype1.97267046
21MP0005499_abnormal_olfactory_system1.97267046
22MP0004957_abnormal_blastocyst_morpholog1.93311862
23MP0003329_amyloid_beta_deposits1.89476966
24MP0001486_abnormal_startle_reflex1.88366909
25MP0008058_abnormal_DNA_repair1.82150928
26MP0003787_abnormal_imprinting1.81826146
27MP0008260_abnormal_autophagy1.78847023
28MP0002733_abnormal_thermal_nociception1.78574320
29MP0002184_abnormal_innervation1.77331084
30MP0001970_abnormal_pain_threshold1.76900220
31MP0009379_abnormal_foot_pigmentation1.65023839
32MP0002160_abnormal_reproductive_system1.64424758
33MP0004858_abnormal_nervous_system1.63797135
34MP0004142_abnormal_muscle_tone1.62904905
35MP0006035_abnormal_mitochondrial_morpho1.57315928
36MP0004133_heterotaxia1.54137838
37MP0010386_abnormal_urinary_bladder1.52126968
38MP0003123_paternal_imprinting1.51867525
39MP0003315_abnormal_perineum_morphology1.50162257
40MP0003077_abnormal_cell_cycle1.48344972
41MP0008877_abnormal_DNA_methylation1.47583876
42MP0001188_hyperpigmentation1.45293630
43MP0003718_maternal_effect1.42048415
44MP0005645_abnormal_hypothalamus_physiol1.36938239
45MP0003646_muscle_fatigue1.36277888
46MP0000372_irregular_coat_pigmentation1.35350802
47MP0000015_abnormal_ear_pigmentation1.31925496
48MP0002272_abnormal_nervous_system1.31328613
49MP0004811_abnormal_neuron_physiology1.27886420
50MP0010030_abnormal_orbit_morphology1.27585073
51MP0000778_abnormal_nervous_system1.26463322
52MP0003121_genomic_imprinting1.25955840
53MP0003186_abnormal_redox_activity1.24261375
54MP0009046_muscle_twitch1.24049988
55MP0010094_abnormal_chromosome_stability1.23496235
56MP0002277_abnormal_respiratory_mucosa1.22689641
57MP0003635_abnormal_synaptic_transmissio1.18521072
58MP0004742_abnormal_vestibular_system1.17947576
59MP0002653_abnormal_ependyma_morphology1.17614729
60MP0008007_abnormal_cellular_replicative1.15371076
61MP0004859_abnormal_synaptic_plasticity1.14088238
62MP0002063_abnormal_learning/memory/cond1.13926783
63MP0002064_seizures1.13129044
64MP0003111_abnormal_nucleus_morphology1.12529780
65MP0002572_abnormal_emotion/affect_behav1.11733700
66MP0002234_abnormal_pharynx_morphology1.10363786
67MP0002229_neurodegeneration1.10032026
68MP0002148_abnormal_hypersensitivity_rea1.09664846
69MP0005646_abnormal_pituitary_gland1.08669475
70MP0000358_abnormal_cell_content/1.08569461
71MP0000049_abnormal_middle_ear1.08288876
72MP0004885_abnormal_endolymph1.08075516
73MP0001502_abnormal_circadian_rhythm1.06443907
74MP0002557_abnormal_social/conspecific_i1.05510302
75MP0008569_lethality_at_weaning1.05057929
76MP0000920_abnormal_myelination1.03214483
77MP0002067_abnormal_sensory_capabilities1.02534267
78MP0005551_abnormal_eye_electrophysiolog1.02167538
79MP0009745_abnormal_behavioral_response1.01995846
80MP0006036_abnormal_mitochondrial_physio1.01518504
81MP0003806_abnormal_nucleotide_metabolis1.01152692
82MP0009333_abnormal_splenocyte_physiolog0.97396675
83MP0002938_white_spotting0.94938073
84MP0002102_abnormal_ear_morphology0.93957934
85MP0002152_abnormal_brain_morphology0.93849762
86MP0003137_abnormal_impulse_conducting0.93148471
87MP0001440_abnormal_grooming_behavior0.91994772
88MP0005423_abnormal_somatic_nervous0.91841357
89MP0004924_abnormal_behavior0.91648093
90MP0005386_behavior/neurological_phenoty0.91648093
91MP0002909_abnormal_adrenal_gland0.91472484
92MP0000681_abnormal_thyroid_gland0.91350865
93MP0005389_reproductive_system_phenotype0.91112517
94MP0002752_abnormal_somatic_nervous0.90513244
95MP0003011_delayed_dark_adaptation0.89875302
96MP0002132_abnormal_respiratory_system0.88335532
97MP0000604_amyloidosis0.87780730
98MP0002882_abnormal_neuron_morphology0.87435195
99MP0000750_abnormal_muscle_regeneration0.86892513
100MP0002163_abnormal_gland_morphology0.86209395
101MP0005253_abnormal_eye_physiology0.84490759
102MP0002876_abnormal_thyroid_physiology0.83961961
103MP0005084_abnormal_gallbladder_morpholo0.83877649
104MP0003633_abnormal_nervous_system0.83288057
105MP0002069_abnormal_eating/drinking_beha0.83278778
106MP0003136_yellow_coat_color0.83008429
107MP0001542_abnormal_bone_strength0.82664442
108MP0003879_abnormal_hair_cell0.76953345
109MP0003631_nervous_system_phenotype0.76046001
110MP0000639_abnormal_adrenal_gland0.75793997
111MP0006072_abnormal_retinal_apoptosis0.75782983
112MP0005410_abnormal_fertilization0.75112641
113MP0004147_increased_porphyrin_level0.74902095
114MP0000955_abnormal_spinal_cord0.74570815
115MP0003786_premature_aging0.74050582
116MP0003634_abnormal_glial_cell0.73124324
117MP0000538_abnormal_urinary_bladder0.73113848
118MP0000858_altered_metastatic_potential0.72792237
119MP0008875_abnormal_xenobiotic_pharmacok0.72735667
120MP0003941_abnormal_skin_development0.72307140
121MP0003938_abnormal_ear_development0.69328593
122MP0001501_abnormal_sleep_pattern0.69135933
123MP0000026_abnormal_inner_ear0.68432501
124MP0002332_abnormal_exercise_endurance0.67980825
125MP0001963_abnormal_hearing_physiology0.67369168
126MP0002066_abnormal_motor_capabilities/c0.66815973
127MP0003942_abnormal_urinary_system0.65180964
128MP0000631_abnormal_neuroendocrine_gland0.64842325
129MP0005367_renal/urinary_system_phenotyp0.64298446
130MP0000516_abnormal_urinary_system0.64298446
131MP0002837_dystrophic_cardiac_calcinosis0.63425735
132MP0008872_abnormal_physiological_respon0.62912632

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.12928138
2Abnormal mitochondria in muscle tissue (HP:0008316)5.57686401
3Mitochondrial inheritance (HP:0001427)5.16176340
4Progressive macrocephaly (HP:0004481)4.96028362
5Increased CSF lactate (HP:0002490)4.51354908
6Acute encephalopathy (HP:0006846)4.48893204
7Hepatocellular necrosis (HP:0001404)4.40863475
8Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.70726755
9Hepatic necrosis (HP:0002605)3.60948866
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.60054967
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.60054967
12Myokymia (HP:0002411)3.59958661
13Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.49271635
14Abnormality of glycolysis (HP:0004366)3.39005064
15Increased serum pyruvate (HP:0003542)3.39005064
16Increased hepatocellular lipid droplets (HP:0006565)3.37352582
17Increased serum lactate (HP:0002151)3.25191969
18Amyotrophic lateral sclerosis (HP:0007354)3.24661380
19Exercise intolerance (HP:0003546)3.18197953
20Respiratory failure (HP:0002878)3.10649233
21Cerebral hypomyelination (HP:0006808)3.01559146
22Optic disc pallor (HP:0000543)2.96458233
23Lactic acidosis (HP:0003128)2.91668664
243-Methylglutaconic aciduria (HP:0003535)2.84306313
25Lipid accumulation in hepatocytes (HP:0006561)2.81490748
26Neuroendocrine neoplasm (HP:0100634)2.79995608
27Leukodystrophy (HP:0002415)2.77033830
28Poor suck (HP:0002033)2.76251457
29Degeneration of anterior horn cells (HP:0002398)2.74744016
30Abnormality of the anterior horn cell (HP:0006802)2.74744016
31Pheochromocytoma (HP:0002666)2.73666966
32Renal Fanconi syndrome (HP:0001994)2.67629048
33Abnormality of cells of the erythroid lineage (HP:0012130)2.65222001
34Limb dystonia (HP:0002451)2.58420844
35Focal motor seizures (HP:0011153)2.57506512
36Exertional dyspnea (HP:0002875)2.53287057
37Type I transferrin isoform profile (HP:0003642)2.50492999
38Cerebral edema (HP:0002181)2.48427266
39Pancreatic fibrosis (HP:0100732)2.47754702
40Microretrognathia (HP:0000308)2.45445688
41Hypothermia (HP:0002045)2.44203928
42Progressive microcephaly (HP:0000253)2.42880209
43Microvesicular hepatic steatosis (HP:0001414)2.40095229
44Rough bone trabeculation (HP:0100670)2.39932793
45Gait imbalance (HP:0002141)2.38651774
46Increased intramyocellular lipid droplets (HP:0012240)2.38478785
47Abnormal number of erythroid precursors (HP:0012131)2.37568130
48Medial flaring of the eyebrow (HP:0010747)2.37140655
49Birth length less than 3rd percentile (HP:0003561)2.33834288
50Abnormal neuron morphology (HP:0012757)2.33497414
51Abnormality of the motor neurons (HP:0002450)2.33497414
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30808611
53Hypoplasia of the brainstem (HP:0002365)2.29235538
54Aplasia/Hypoplasia of the brainstem (HP:0007362)2.29235538
55True hermaphroditism (HP:0010459)2.28222533
56Mutism (HP:0002300)2.28082877
57Congenital primary aphakia (HP:0007707)2.27644511
58Nephrogenic diabetes insipidus (HP:0009806)2.26947096
59Carpal bone hypoplasia (HP:0001498)2.26926949
60Failure to thrive in infancy (HP:0001531)2.26519482
61Ankle clonus (HP:0011448)2.26517316
62Abnormal hair whorl (HP:0010721)2.26346399
63Breast hypoplasia (HP:0003187)2.26283216
64Irregular epiphyses (HP:0010582)2.24405925
65Focal seizures (HP:0007359)2.23818916
66Emotional lability (HP:0000712)2.22419231
67Amblyopia (HP:0000646)2.22004045
68Supranuclear gaze palsy (HP:0000605)2.20691450
69Pancreatic cysts (HP:0001737)2.20572136
70Opisthotonus (HP:0002179)2.19972061
71Visual hallucinations (HP:0002367)2.19961549
72Respiratory difficulties (HP:0002880)2.19709916
73Reticulocytopenia (HP:0001896)2.12662674
74Patellar aplasia (HP:0006443)2.11013139
75Delusions (HP:0000746)2.06965421
76Abnormal eating behavior (HP:0100738)2.06514997
77Tongue fasciculations (HP:0001308)2.04842706
78X-linked dominant inheritance (HP:0001423)2.03514021
79Split foot (HP:0001839)2.00751680
80Aplastic anemia (HP:0001915)1.97918966
81Polyphagia (HP:0002591)1.94912009
82Aplasia/Hypoplasia of the patella (HP:0006498)1.94874623
83Focal dystonia (HP:0004373)1.94331582
84Ragged-red muscle fibers (HP:0003200)1.92185901
85Epileptic encephalopathy (HP:0200134)1.90491543
86Atrophy/Degeneration involving motor neurons (HP:0007373)1.90027453
87Gliosis (HP:0002171)1.89754044
88Facial cleft (HP:0002006)1.89286273
89Genital tract atresia (HP:0001827)1.88203682
90Optic nerve coloboma (HP:0000588)1.87779592
91Vaginal atresia (HP:0000148)1.86784491
92Lissencephaly (HP:0001339)1.86468189
93Craniofacial dystonia (HP:0012179)1.86409570
94Abnormality of the labia minora (HP:0012880)1.86336161
95CNS demyelination (HP:0007305)1.85743745
96Muscular hypotonia of the trunk (HP:0008936)1.85517140
97Severe visual impairment (HP:0001141)1.84474425
98Spastic gait (HP:0002064)1.84088730
99Abnormal trabecular bone morphology (HP:0100671)1.83757905
100Unsteady gait (HP:0002317)1.82266384
101Neoplasm of the peripheral nervous system (HP:0100007)1.82201049
102Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.81557962
103Delayed CNS myelination (HP:0002188)1.81273538
104Abnormality of the vocal cords (HP:0008777)1.80842682
105Molar tooth sign on MRI (HP:0002419)1.80027660
106Abnormality of midbrain morphology (HP:0002418)1.80027660
107Hydroureter (HP:0000072)1.79698466
108Upper limb muscle weakness (HP:0003484)1.79684458
109Oral leukoplakia (HP:0002745)1.79509664
110Aplasia/hypoplasia of the uterus (HP:0008684)1.79089930
111Sclerocornea (HP:0000647)1.77979733
112Esotropia (HP:0000565)1.77257580
113Torticollis (HP:0000473)1.76432202
114Spastic tetraplegia (HP:0002510)1.75448002
115Increased muscle lipid content (HP:0009058)1.75111582
116Methylmalonic aciduria (HP:0012120)1.75001073
117Peripheral hypomyelination (HP:0007182)1.73416051
118Lethargy (HP:0001254)1.72730735
119Agitation (HP:0000713)1.71798682
120Premature graying of hair (HP:0002216)1.71180435
121Muscle fibrillation (HP:0010546)1.71071843
122Anomalous pulmonary venous return (HP:0010772)1.70966710
123Abnormality of magnesium homeostasis (HP:0004921)1.70097867
124Abnormality of the lower motor neuron (HP:0002366)1.69259070
125Abnormality of the corticospinal tract (HP:0002492)1.68280482
126Hypsarrhythmia (HP:0002521)1.67896130
127Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67618288
128Blindness (HP:0000618)1.67448490
129Epileptiform EEG discharges (HP:0011182)1.67149237
130Pachygyria (HP:0001302)1.66638821
131Hypokinesia (HP:0002375)1.66618514
132Cerebral palsy (HP:0100021)1.66400626
133Cleft eyelid (HP:0000625)1.66204923
134Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66097946
135Pallor (HP:0000980)1.65018252
136Decreased electroretinogram (ERG) amplitude (HP:0000654)1.64842072
137Macrocytic anemia (HP:0001972)1.64199016
138Poor head control (HP:0002421)1.62533986
139Retinal dysplasia (HP:0007973)1.62049910
140Short tibia (HP:0005736)1.61747534
141Type 2 muscle fiber atrophy (HP:0003554)1.61644237
142Palpitations (HP:0001962)1.61432610
143Abnormal lung lobation (HP:0002101)1.61305517
144Bifid tongue (HP:0010297)1.61039234
145CNS hypomyelination (HP:0003429)1.60987941
146Cellular immunodeficiency (HP:0005374)1.60323105

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.29303782
2ARAF3.52143970
3VRK23.22136309
4STK163.17093009
5BCKDK3.12219080
6CASK2.93014760
7PIM22.69495181
8TESK22.63805863
9TESK12.62339705
10LIMK12.58009718
11NME22.47303102
12BRAF2.28844637
13MAP3K122.23043850
14MARK12.22884756
15DYRK22.22848814
16EIF2AK11.99225701
17MAP4K21.93115091
18NME11.91825384
19CSNK1G21.90611861
20VRK11.90589696
21CSNK1A1L1.86988805
22PLK41.83263148
23EPHA41.79030586
24PAK61.70166455
25SRPK11.66770184
26TLK11.66697122
27EIF2AK31.62334456
28MAP2K71.57640403
29NEK11.52283739
30MINK11.49212441
31ERBB31.48062398
32WEE11.47840947
33PBK1.47188467
34MAPK131.44777763
35SIK31.44072157
36CSNK1G11.44058167
37BCR1.35770889
38PLK21.34458405
39DAPK21.32783147
40TSSK61.32498309
41CDK191.30213447
42AURKA1.18924164
43TRIM281.18826306
44YES11.12978423
45PRKD31.09983452
46PLK31.09651736
47GRK51.09061411
48NTRK21.07752725
49DAPK11.02575790
50DYRK31.00903569
51IRAK40.98312673
52CCNB10.97124410
53BMPR20.95122943
54PKN10.92891448
55AKT30.90288271
56MYLK0.89891683
57ZAK0.89124297
58MAP2K40.88924481
59ABL20.86125383
60BRSK10.84842946
61CDK140.83259230
62PINK10.82600335
63BLK0.82310979
64MKNK10.81970569
65STK240.80572578
66ADRBK20.80422209
67CAMKK10.80065186
68PRKCI0.79421267
69CDK180.78429047
70ACVR1B0.76775811
71ILK0.76329814
72UHMK10.75901117
73PLK10.74789895
74DAPK30.73209873
75CDK50.73170032
76BMPR1B0.72680744
77CDC70.71350787
78GRK70.69028510
79SIK20.68936939
80MST40.67002662
81CDK150.66576724
82STK38L0.66375441
83DYRK1B0.65379711
84CDK11A0.64134014
85PHKG10.63785510
86PHKG20.63785510
87PRPF4B0.63503477
88CAMK2A0.62846769
89* PAK10.60938591
90MAPKAPK30.60885316
91TAOK20.60448198
92LMTK20.60033617
93MAP3K40.59001284
94EIF2AK20.56961026
95CSNK2A10.55492800
96PRKCG0.54653623
97RPS6KA20.54276491
98NTRK10.53439876
99ADRBK10.50656580
100WNK30.50209693
101LATS20.49800075
102CAMK2G0.49230531
103CAMK2B0.44383367
104MAP3K110.44034652
105CSNK1G30.43961370
106NTRK30.43864319
107GRK60.42546022
108BRSK20.42177810
109MAP3K50.41676097
110CAMKK20.41453355
111PAK30.40627161
112RPS6KL10.39955276
113RPS6KC10.39955276
114RPS6KA50.39711094
115EPHB20.38474899
116MAPKAPK50.38114149
117AURKB0.38030393
118CSNK2A20.37757740
119FES0.37545045
120DYRK1A0.36959815
121CSNK1A10.35613511
122PAK40.33641660
123PASK0.33595579
124RAF10.32963449
125RPS6KA40.32873665
126KDR0.32785747
127SCYL20.32657682
128CDK80.31947916
129CAMK2D0.31585389
130CHEK20.30263915
131RPS6KA60.28777255
132PRKACA0.26559114
133PRKCZ0.25618525
134ATR0.25347075
135PRKCA0.22661032
136PRKD10.21920756

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.33252185
2Oxidative phosphorylation_Homo sapiens_hsa001904.54802355
3Parkinsons disease_Homo sapiens_hsa050124.02446329
4Ribosome_Homo sapiens_hsa030103.64788730
5RNA polymerase_Homo sapiens_hsa030203.33364240
6Huntingtons disease_Homo sapiens_hsa050163.07301648
7Alzheimers disease_Homo sapiens_hsa050102.73657521
8DNA replication_Homo sapiens_hsa030302.48906359
9Protein export_Homo sapiens_hsa030602.38126862
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.22125072
11Pyrimidine metabolism_Homo sapiens_hsa002402.21827086
12Mismatch repair_Homo sapiens_hsa034302.21469442
13Spliceosome_Homo sapiens_hsa030402.08355675
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.01021061
15Synaptic vesicle cycle_Homo sapiens_hsa047211.90975969
16Collecting duct acid secretion_Homo sapiens_hsa049661.87468229
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81291785
18Fatty acid elongation_Homo sapiens_hsa000621.75904630
19Cardiac muscle contraction_Homo sapiens_hsa042601.71177316
20Base excision repair_Homo sapiens_hsa034101.66832445
21Vibrio cholerae infection_Homo sapiens_hsa051101.65683972
22Nucleotide excision repair_Homo sapiens_hsa034201.59695945
23RNA transport_Homo sapiens_hsa030131.55354057
24Basal transcription factors_Homo sapiens_hsa030221.45771105
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.39184776
26Homologous recombination_Homo sapiens_hsa034401.35168649
27Purine metabolism_Homo sapiens_hsa002301.30492030
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28665415
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.25862660
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24727264
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19560453
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17941871
33Phagosome_Homo sapiens_hsa041451.08064960
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06880236
35Cell cycle_Homo sapiens_hsa041101.06647798
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05968545
37Epstein-Barr virus infection_Homo sapiens_hsa051691.00731321
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00003539
39Biosynthesis of amino acids_Homo sapiens_hsa012300.99569920
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95891364
41Rheumatoid arthritis_Homo sapiens_hsa053230.95769314
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93001370
43RNA degradation_Homo sapiens_hsa030180.92575361
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90018342
45Circadian entrainment_Homo sapiens_hsa047130.87726219
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84731268
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82076229
48Regulation of autophagy_Homo sapiens_hsa041400.79462876
49Peroxisome_Homo sapiens_hsa041460.76947769
50Steroid biosynthesis_Homo sapiens_hsa001000.74715279
51Glutamatergic synapse_Homo sapiens_hsa047240.74302070
52Amphetamine addiction_Homo sapiens_hsa050310.73713531
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72898718
54Legionellosis_Homo sapiens_hsa051340.71829953
55Cocaine addiction_Homo sapiens_hsa050300.71039952
56Type I diabetes mellitus_Homo sapiens_hsa049400.69982206
57Fanconi anemia pathway_Homo sapiens_hsa034600.68204510
58Asthma_Homo sapiens_hsa053100.63958719
59Arginine and proline metabolism_Homo sapiens_hsa003300.63817137
60Olfactory transduction_Homo sapiens_hsa047400.61935701
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61512322
62Oocyte meiosis_Homo sapiens_hsa041140.61215542
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60523880
64Phototransduction_Homo sapiens_hsa047440.58367506
65Shigellosis_Homo sapiens_hsa051310.56282862
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55639784
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54918675
68Graft-versus-host disease_Homo sapiens_hsa053320.54566211
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53553292
70Alcoholism_Homo sapiens_hsa050340.53245611
71p53 signaling pathway_Homo sapiens_hsa041150.53023245
72One carbon pool by folate_Homo sapiens_hsa006700.52673305
73Nicotine addiction_Homo sapiens_hsa050330.51530615
74Salmonella infection_Homo sapiens_hsa051320.49447069
75Serotonergic synapse_Homo sapiens_hsa047260.47737770
76Metabolic pathways_Homo sapiens_hsa011000.47350550
77Allograft rejection_Homo sapiens_hsa053300.47024035
78Primary immunodeficiency_Homo sapiens_hsa053400.45915970
79Glutathione metabolism_Homo sapiens_hsa004800.44102842
80Axon guidance_Homo sapiens_hsa043600.42688736
81Endocytosis_Homo sapiens_hsa041440.42641315
82Salivary secretion_Homo sapiens_hsa049700.40656489
83Pentose phosphate pathway_Homo sapiens_hsa000300.40373838
84mRNA surveillance pathway_Homo sapiens_hsa030150.40111362
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39542534
86Insulin secretion_Homo sapiens_hsa049110.39226252
87Taste transduction_Homo sapiens_hsa047420.38761603
88Thyroid cancer_Homo sapiens_hsa052160.38730849
89Arachidonic acid metabolism_Homo sapiens_hsa005900.38525181
90Galactose metabolism_Homo sapiens_hsa000520.38307309
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37776406
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36880073
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36106796
94Folate biosynthesis_Homo sapiens_hsa007900.35768031
95Fructose and mannose metabolism_Homo sapiens_hsa000510.34883173
96Sulfur relay system_Homo sapiens_hsa041220.34759449
97Non-homologous end-joining_Homo sapiens_hsa034500.34593114
98Dopaminergic synapse_Homo sapiens_hsa047280.33938689
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33500878
100N-Glycan biosynthesis_Homo sapiens_hsa005100.32493986
101beta-Alanine metabolism_Homo sapiens_hsa004100.31557402
102Phenylalanine metabolism_Homo sapiens_hsa003600.31016640
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29435580
104Autoimmune thyroid disease_Homo sapiens_hsa053200.25117729
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.24533302
106Butanoate metabolism_Homo sapiens_hsa006500.24055008
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.22165932
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22031040
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21854131
110Viral myocarditis_Homo sapiens_hsa054160.21658932
111Gastric acid secretion_Homo sapiens_hsa049710.21613791
112Pertussis_Homo sapiens_hsa051330.21517735
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20776297
114Tuberculosis_Homo sapiens_hsa051520.19892640
115Antigen processing and presentation_Homo sapiens_hsa046120.17786997
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17702591
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16989563
118Gap junction_Homo sapiens_hsa045400.16463455
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16163545
120Systemic lupus erythematosus_Homo sapiens_hsa053220.16142900
121Melanoma_Homo sapiens_hsa052180.15930982
122Apoptosis_Homo sapiens_hsa042100.15728143
123Ether lipid metabolism_Homo sapiens_hsa005650.15296287
124Viral carcinogenesis_Homo sapiens_hsa052030.14728112
125Morphine addiction_Homo sapiens_hsa050320.14336894
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.14038145
127Pyruvate metabolism_Homo sapiens_hsa006200.13508457
128Carbon metabolism_Homo sapiens_hsa012000.12272645
129GABAergic synapse_Homo sapiens_hsa047270.11752680
130Cholinergic synapse_Homo sapiens_hsa047250.11224662
131Sulfur metabolism_Homo sapiens_hsa009200.10778304

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