TBCC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.44343986
2viral transcription (GO:0019083)5.68036338
3translational termination (GO:0006415)5.49834544
4proteasome assembly (GO:0043248)5.15211794
5ribosomal small subunit assembly (GO:0000028)5.13019473
6ribosomal small subunit biogenesis (GO:0042274)5.03641565
7translational elongation (GO:0006414)4.97251945
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.78740282
9cotranslational protein targeting to membrane (GO:0006613)4.71154514
10protein targeting to ER (GO:0045047)4.68316377
11maturation of SSU-rRNA (GO:0030490)4.67303276
12cytidine metabolic process (GO:0046087)4.63429446
13cytidine catabolic process (GO:0006216)4.63429446
14cytidine deamination (GO:0009972)4.63429446
15translational initiation (GO:0006413)4.59765967
16protein localization to endoplasmic reticulum (GO:0070972)4.49876571
17ribosomal large subunit biogenesis (GO:0042273)4.46851061
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.42420262
19cellular protein complex disassembly (GO:0043624)4.42267058
20transcription elongation from RNA polymerase III promoter (GO:0006385)4.41811073
21termination of RNA polymerase III transcription (GO:0006386)4.41811073
22viral life cycle (GO:0019058)4.40877652
23platelet dense granule organization (GO:0060155)4.34985994
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.32443251
25spliceosomal snRNP assembly (GO:0000387)4.24665497
26ribonucleoprotein complex biogenesis (GO:0022613)4.16215207
27chaperone-mediated protein transport (GO:0072321)4.11640408
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.11043971
29protein complex disassembly (GO:0043241)4.01688556
30regulation of mitochondrial translation (GO:0070129)3.99527672
31pyrimidine ribonucleoside catabolic process (GO:0046133)3.98903645
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.96733044
33translation (GO:0006412)3.95672606
34pseudouridine synthesis (GO:0001522)3.94253117
35guanosine-containing compound biosynthetic process (GO:1901070)3.93345899
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.90660818
37purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.87508216
38macromolecular complex disassembly (GO:0032984)3.86883148
39protein deneddylation (GO:0000338)3.86458446
40pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.85974507
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.84070105
42ribosome biogenesis (GO:0042254)3.82890416
43L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.77450932
44GTP biosynthetic process (GO:0006183)3.72423462
45cullin deneddylation (GO:0010388)3.68172795
46cellular component biogenesis (GO:0044085)3.68095172
47negative regulation of telomere maintenance (GO:0032205)3.67029425
48negative regulation of ligase activity (GO:0051352)3.65468588
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.65468588
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.62791696
51rRNA processing (GO:0006364)3.60352383
52deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.60126300
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.59150589
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57518623
55protein targeting to mitochondrion (GO:0006626)3.55728532
56negative regulation of B cell apoptotic process (GO:0002903)3.54835422
57establishment of protein localization to mitochondrion (GO:0072655)3.54395618
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.53167509
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.53167509
60purine deoxyribonucleotide catabolic process (GO:0009155)3.50395014
61exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.48883152
62Arp2/3 complex-mediated actin nucleation (GO:0034314)3.48451642
63DNA strand elongation involved in DNA replication (GO:0006271)3.47844198
64cellular response to interleukin-15 (GO:0071350)3.47765150
65formation of translation preinitiation complex (GO:0001731)3.47502990
66rRNA metabolic process (GO:0016072)3.47398261
67iron-sulfur cluster assembly (GO:0016226)3.46872455
68metallo-sulfur cluster assembly (GO:0031163)3.46872455
69UTP biosynthetic process (GO:0006228)3.45468723
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43893236
71GMP metabolic process (GO:0046037)3.43223416
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.40347243
73regulation of cellular amino acid metabolic process (GO:0006521)3.39529648
74positive regulation of defense response to virus by host (GO:0002230)3.39203297
75DNA replication checkpoint (GO:0000076)3.38326421
76spliceosomal complex assembly (GO:0000245)3.35713348
77DNA replication initiation (GO:0006270)3.34707885
787-methylguanosine mRNA capping (GO:0006370)3.34028609
79negative regulation of T cell apoptotic process (GO:0070233)3.32546453
80GDP-mannose metabolic process (GO:0019673)3.30947568
81nuclear-transcribed mRNA catabolic process (GO:0000956)3.30386054
82establishment of integrated proviral latency (GO:0075713)3.29652760
83positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.28712421
84DNA strand elongation (GO:0022616)3.26802951
85telomere maintenance via semi-conservative replication (GO:0032201)3.26348077
86purine deoxyribonucleotide metabolic process (GO:0009151)3.22740762
87RNA capping (GO:0036260)3.22644607
887-methylguanosine RNA capping (GO:0009452)3.22644607
89protein localization to mitochondrion (GO:0070585)3.22345070
90positive regulation of ligase activity (GO:0051351)3.21406672
91rRNA modification (GO:0000154)3.20345467
92sequestering of actin monomers (GO:0042989)3.19581724
93protein targeting to membrane (GO:0006612)3.19203766
94pyrimidine nucleotide catabolic process (GO:0006244)3.17819409
95DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17185159
96ribosome assembly (GO:0042255)3.15949566
97CTP metabolic process (GO:0046036)3.13827814
98CTP biosynthetic process (GO:0006241)3.13827814
99intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12860866
100signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12860866
101positive regulation of B cell differentiation (GO:0045579)3.11876601
102positive regulation of mitochondrial fission (GO:0090141)3.11553284
103negative regulation of lymphocyte apoptotic process (GO:0070229)3.11088948
104protein complex biogenesis (GO:0070271)3.10773548
105regulation of activation of Janus kinase activity (GO:0010533)3.10345943
106signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.09856446
107signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.09856446
108signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.09856446
109mRNA catabolic process (GO:0006402)3.09584358
110establishment of protein localization to mitochondrial membrane (GO:0090151)3.09542852
111DNA damage response, detection of DNA damage (GO:0042769)3.09394058
112pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.08744944
113mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08690216
114negative regulation of cell killing (GO:0031342)3.08315947
115negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.08315947
116pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.07271957
117UTP metabolic process (GO:0046051)3.05180631
118actin nucleation (GO:0045010)3.05104005
119signal transduction involved in DNA damage checkpoint (GO:0072422)3.03988430
120signal transduction involved in DNA integrity checkpoint (GO:0072401)3.03988430
121amino acid salvage (GO:0043102)3.03875692
122L-methionine salvage (GO:0071267)3.03875692
123L-methionine biosynthetic process (GO:0071265)3.03875692
124mannosylation (GO:0097502)3.03633662
125mitochondrial respiratory chain complex I assembly (GO:0032981)3.03443873
126NADH dehydrogenase complex assembly (GO:0010257)3.03443873
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.03443873
128purine nucleobase biosynthetic process (GO:0009113)3.02716066
129deoxyribonucleotide catabolic process (GO:0009264)3.00825507
130protein complex localization (GO:0031503)3.00706326
131regulation of T cell mediated cytotoxicity (GO:0001914)3.00433586
1322-deoxyribonucleotide biosynthetic process (GO:0009265)3.00347468
133deoxyribose phosphate biosynthetic process (GO:0046385)3.00347468
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.97452749
135mitochondrial calcium ion transport (GO:0006851)2.96384722
136regulation of defense response to virus by host (GO:0050691)2.96074521
137negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.94518078
138negative T cell selection (GO:0043383)2.92638854
139positive regulation of interleukin-8 secretion (GO:2000484)2.91444642
140negative thymic T cell selection (GO:0045060)2.89993303
141regulation of T cell apoptotic process (GO:0070232)2.86806015
142interferon-gamma production (GO:0032609)2.85112965
143mitochondrial respiratory chain complex assembly (GO:0033108)2.84638847
144deoxyribose phosphate catabolic process (GO:0046386)2.83944731
145response to interferon-beta (GO:0035456)2.83073410
146positive thymic T cell selection (GO:0045059)2.82922381
147antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.82551029
148regulation of regulatory T cell differentiation (GO:0045589)2.78608768
149immunoglobulin mediated immune response (GO:0016064)2.78231101
150response to interleukin-15 (GO:0070672)2.76725857
151signal transduction involved in cell cycle checkpoint (GO:0072395)2.74694696
152cytochrome complex assembly (GO:0017004)2.72515831
153positive regulation of T cell mediated cytotoxicity (GO:0001916)2.70610359
154regulation of B cell apoptotic process (GO:0002902)2.69900407
155base-excision repair, AP site formation (GO:0006285)2.69651679
156respiratory chain complex IV assembly (GO:0008535)2.69522201
1572-deoxyribonucleotide metabolic process (GO:0009394)2.68473865
158nucleoside transmembrane transport (GO:1901642)2.66998549
159regulation of leukocyte mediated cytotoxicity (GO:0001910)2.65872977
160regulation of lymphocyte apoptotic process (GO:0070228)2.65844760
161antigen processing and presentation of endogenous antigen (GO:0019883)2.64824619
162mast cell activation involved in immune response (GO:0002279)2.61716425
163mast cell degranulation (GO:0043303)2.61716425
164chaperone mediated protein folding requiring cofactor (GO:0051085)2.61479976
165protein maturation by protein folding (GO:0022417)2.56768256
166positive regulation of gamma-delta T cell activation (GO:0046645)2.55973398
167piRNA metabolic process (GO:0034587)2.55447603
168T cell migration (GO:0072678)2.53072661
169ubiquinone biosynthetic process (GO:0006744)2.51270231
170deoxyribose phosphate metabolic process (GO:0019692)2.50737472
171positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.50091611

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.13537523
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.01734153
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.74538348
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.70565214
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.54414594
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.44105541
7MYC_18358816_ChIP-ChIP_MESCs_Mouse3.16742752
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11984722
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.08110366
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.04336878
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.01845730
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.94779047
13E2F7_22180533_ChIP-Seq_HELA_Human2.93154106
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.78431644
15XRN2_22483619_ChIP-Seq_HELA_Human2.74207821
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.68129709
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.65315230
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59432999
19* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59262418
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.58487486
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44976984
22* VDR_23849224_ChIP-Seq_CD4+_Human2.43804658
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42469800
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36887430
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.36512219
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34033156
27DCP1A_22483619_ChIP-Seq_HELA_Human2.31151873
28GABP_19822575_ChIP-Seq_HepG2_Human2.28246940
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.22393096
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22148381
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.18780823
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13551705
33IRF8_21731497_ChIP-ChIP_J774_Mouse2.12322954
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09490327
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05628833
36ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05339256
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.05325949
38TTF2_22483619_ChIP-Seq_HELA_Human2.04207751
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02865897
40* FOXP3_21729870_ChIP-Seq_TREG_Human2.00322946
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.99716942
42* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96798613
43MYB_26560356_Chip-Seq_TH2_Human1.94619777
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93260974
45* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.92658701
46* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.92644355
47* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84901903
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.78913567
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77251959
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.75638688
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75525170
52CIITA_25753668_ChIP-Seq_RAJI_Human1.74785534
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.73771804
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72100640
55ZNF274_21170338_ChIP-Seq_K562_Hela1.69243151
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.67740192
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.62933208
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.62463471
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62317817
60* SPI1_23547873_ChIP-Seq_NB4_Human1.62121503
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.62101273
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61265032
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55795985
64* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53659980
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.53490268
66MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53407890
67* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51852031
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51069341
69UTX_26944678_Chip-Seq_JUKART_Human1.49417321
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48372720
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48361431
72* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48202527
73BCL6_27268052_Chip-Seq_Bcells_Human1.46511539
74GATA3_27048872_Chip-Seq_THYMUS_Human1.44928777
75* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43614470
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.42760856
77IRF1_19129219_ChIP-ChIP_H3396_Human1.42415063
78CTCF_18555785_ChIP-Seq_MESCs_Mouse1.39536526
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38195619
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.37580989
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36018376
82* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34976638
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34527437
84GATA3_26560356_Chip-Seq_TH2_Human1.32966205
85VDR_21846776_ChIP-Seq_THP-1_Human1.32903421
86MYB_26560356_Chip-Seq_TH1_Human1.32157577
87* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31424314
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31243702
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.30645052
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28105113
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27510441
92LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27095770
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.25812423
94ELK1_22589737_ChIP-Seq_MCF10A_Human1.25715098
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24249887
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21252018
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.21197829
98ZNF263_19887448_ChIP-Seq_K562_Human1.21158074
99RUNX_20019798_ChIP-Seq_JUKART_Human1.20497368
100* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18229296
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18218017
102MAF_26560356_Chip-Seq_TH1_Human1.17305297
103P300_27268052_Chip-Seq_Bcells_Human1.16763846
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15460844
105MYC_18940864_ChIP-ChIP_HL60_Human1.15460711
106MAF_26560356_Chip-Seq_TH2_Human1.15246706
107EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14765382
108* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14725175
109MYC_22102868_ChIP-Seq_BL_Human1.14422066
110ELK1_19687146_ChIP-ChIP_HELA_Human1.13398910
111* NOTCH1_21737748_ChIP-Seq_TLL_Human1.12864093
112ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12508780
113FOXP1_21924763_ChIP-Seq_HESCs_Human1.11283726
114BCOR_27268052_Chip-Seq_Bcells_Human1.10524601
115TET1_21451524_ChIP-Seq_MESCs_Mouse1.09891609
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08096555
117E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07439979
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05641973
119KDM5A_27292631_Chip-Seq_BREAST_Human1.05624372
120* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05235395
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.04163295
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03751562
123* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02629159
124TP53_22573176_ChIP-Seq_HFKS_Human1.02374147
125* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99844577
126TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99651348
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99226314
128EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98610566
129SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98560255
130* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97111227
131E2F1_20622854_ChIP-Seq_HELA_Human0.96062057
132SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96053438
133PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95911879
134SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95003881
135IGF1R_20145208_ChIP-Seq_DFB_Human0.94214840
136PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94019638
137* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93606157
138NANOG_20526341_ChIP-Seq_ESCs_Human0.93425731
139ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92620737
140OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91321860
141E2F1_21310950_ChIP-Seq_MCF-7_Human0.90986347
142PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90873513
143RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90534547
144FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88955350

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.08747756
2MP0005671_abnormal_response_to3.95286854
3MP0009379_abnormal_foot_pigmentation3.89423805
4MP0004957_abnormal_blastocyst_morpholog3.65196004
5MP0003111_abnormal_nucleus_morphology3.23940877
6MP0010030_abnormal_orbit_morphology2.84882784
7MP0008932_abnormal_embryonic_tissue2.80696884
8MP0002653_abnormal_ependyma_morphology2.78937067
9MP0009785_altered_susceptibility_to2.73014096
10MP0003077_abnormal_cell_cycle2.66469472
11MP0008007_abnormal_cellular_replicative2.61543775
12MP0001835_abnormal_antigen_presentation2.58168578
13MP0005410_abnormal_fertilization2.55793215
14MP0008058_abnormal_DNA_repair2.51713515
15MP0010094_abnormal_chromosome_stability2.42701630
16MP0005000_abnormal_immune_tolerance2.40749188
17MP0003786_premature_aging2.38388418
18MP0006276_abnormal_autonomic_nervous2.32515318
19MP0005025_abnormal_response_to2.21538638
20MP0001800_abnormal_humoral_immune2.17226206
21MP0002420_abnormal_adaptive_immunity2.16302409
22MP0002723_abnormal_immune_serum2.14857590
23MP0003724_increased_susceptibility_to2.11716807
24MP0001819_abnormal_immune_cell2.10514372
25MP0002148_abnormal_hypersensitivity_rea2.09617370
26MP0005645_abnormal_hypothalamus_physiol2.04237665
27MP0003646_muscle_fatigue2.01940759
28MP0003787_abnormal_imprinting2.00800314
29MP0003436_decreased_susceptibility_to1.91502226
30MP0002452_abnormal_antigen_presenting1.91360182
31MP0006292_abnormal_olfactory_placode1.85553294
32MP0009333_abnormal_splenocyte_physiolog1.85034089
33MP0001529_abnormal_vocalization1.81318919
34MP0003315_abnormal_perineum_morphology1.79747859
35MP0001730_embryonic_growth_arrest1.77454199
36MP0001790_abnormal_immune_system1.73754045
37MP0005387_immune_system_phenotype1.73754045
38MP0000716_abnormal_immune_system1.72279169
39MP0003718_maternal_effect1.67806661
40MP0002419_abnormal_innate_immunity1.65483334
41MP0006036_abnormal_mitochondrial_physio1.65158641
42MP0008057_abnormal_DNA_replication1.65086571
43MP0000490_abnormal_crypts_of1.60845524
44MP0008260_abnormal_autophagy1.59130321
45MP0008789_abnormal_olfactory_epithelium1.58641333
46MP0000350_abnormal_cell_proliferation1.55971652
47MP0003123_paternal_imprinting1.54310929
48MP0001929_abnormal_gametogenesis1.52256774
49MP0009764_decreased_sensitivity_to1.48843205
50MP0002210_abnormal_sex_determination1.48515977
51MP0006072_abnormal_retinal_apoptosis1.44943762
52MP0003866_abnormal_defecation1.44888773
53MP0001348_abnormal_lacrimal_gland1.42607035
54MP0004133_heterotaxia1.41875841
55MP0002638_abnormal_pupillary_reflex1.41008276
56MP0002405_respiratory_system_inflammati1.40092898
57MP0002160_abnormal_reproductive_system1.37783292
58MP0000358_abnormal_cell_content/1.37326695
59MP0003698_abnormal_male_reproductive1.36860932
60MP0005464_abnormal_platelet_physiology1.35078344
61MP0001845_abnormal_inflammatory_respons1.34718589
62MP0001145_abnormal_male_reproductive1.34531623
63MP0000015_abnormal_ear_pigmentation1.33562210
64MP0001697_abnormal_embryo_size1.32881121
65MP0003656_abnormal_erythrocyte_physiolo1.32516352
66MP0006082_CNS_inflammation1.31524097
67MP0002751_abnormal_autonomic_nervous1.30905099
68MP0001853_heart_inflammation1.30894396
69MP0000313_abnormal_cell_death1.29081094
70MP0002102_abnormal_ear_morphology1.27823297
71MP0003763_abnormal_thymus_physiology1.24668687
72MP0002080_prenatal_lethality1.24421226
73MP0004147_increased_porphyrin_level1.23016629
74MP0005397_hematopoietic_system_phenotyp1.22700062
75MP0001545_abnormal_hematopoietic_system1.22700062
76MP0004142_abnormal_muscle_tone1.20554229
77MP0003136_yellow_coat_color1.19619941
78MP0008469_abnormal_protein_level1.17217528
79MP0003806_abnormal_nucleotide_metabolis1.15648541
80MP0000465_gastrointestinal_hemorrhage1.14559836
81MP0002019_abnormal_tumor_incidence1.13550625
82MP0003011_delayed_dark_adaptation1.13261513
83MP0003195_calcinosis1.11092767
84MP0000653_abnormal_sex_gland1.09127566
85MP0009765_abnormal_xenobiotic_induced1.09015179
86MP0010155_abnormal_intestine_physiology1.08328721
87MP0003938_abnormal_ear_development1.08183584
88MP0000049_abnormal_middle_ear1.07334096
89MP0002396_abnormal_hematopoietic_system1.06374615
90MP0001986_abnormal_taste_sensitivity1.04154580
91MP0002166_altered_tumor_susceptibility1.03991580
92MP0004381_abnormal_hair_follicle1.03873919
93MP0002085_abnormal_embryonic_tissue1.01079157
94MP0008995_early_reproductive_senescence1.00465897
95MP0005499_abnormal_olfactory_system0.99399504
96MP0005394_taste/olfaction_phenotype0.99399504
97MP0002132_abnormal_respiratory_system0.97925721
98MP0006035_abnormal_mitochondrial_morpho0.96727860
99MP0008872_abnormal_physiological_respon0.96087162
100MP0000703_abnormal_thymus_morphology0.94345568
101MP0008877_abnormal_DNA_methylation0.93410771
102MP0002693_abnormal_pancreas_physiology0.92767332
103MP0000689_abnormal_spleen_morphology0.90224588
104MP0002161_abnormal_fertility/fecundity0.90119030
105MP0008873_increased_physiological_sensi0.90070894
106MP0001727_abnormal_embryo_implantation0.86848863
107MP0003221_abnormal_cardiomyocyte_apopto0.85703288
108MP0002722_abnormal_immune_system0.85643951
109MP0001873_stomach_inflammation0.85514710
110MP0001905_abnormal_dopamine_level0.84660442
111MP0009763_increased_sensitivity_to0.84053489
112MP0004043_abnormal_pH_regulation0.83879033
113MP0002006_tumorigenesis0.83362907
114MP0002398_abnormal_bone_marrow0.82149893
115MP0000372_irregular_coat_pigmentation0.81254036
116MP0002095_abnormal_skin_pigmentation0.80586548
117MP0003186_abnormal_redox_activity0.80299901
118MP0004947_skin_inflammation0.79387112
119MP0002084_abnormal_developmental_patter0.79132229
120MP0002138_abnormal_hepatobiliary_system0.78069944
121MP0009278_abnormal_bone_marrow0.77210334
122MP0008875_abnormal_xenobiotic_pharmacok0.77068939
123MP0000858_altered_metastatic_potential0.76963677
124MP0005174_abnormal_tail_pigmentation0.76343934
125MP0001968_abnormal_touch/_nociception0.75699988
126MP0002736_abnormal_nociception_after0.75583680
127MP0001188_hyperpigmentation0.75524685
128MP0005083_abnormal_biliary_tract0.75261416
129MP0001542_abnormal_bone_strength0.74190823
130MP0002733_abnormal_thermal_nociception0.73889228
131MP0002184_abnormal_innervation0.73402746
132MP0005389_reproductive_system_phenotype0.71944446
133MP0004808_abnormal_hematopoietic_stem0.71485354
134MP0005646_abnormal_pituitary_gland0.71242091
135MP0005220_abnormal_exocrine_pancreas0.70514643
136MP0003121_genomic_imprinting0.69999135
137MP0005075_abnormal_melanosome_morpholog0.69128894
138MP0001672_abnormal_embryogenesis/_devel0.69094954
139MP0005380_embryogenesis_phenotype0.69094954
140MP0001764_abnormal_homeostasis0.68908543
141MP0002752_abnormal_somatic_nervous0.68815223
142MP0005636_abnormal_mineral_homeostasis0.68136840
143MP0002429_abnormal_blood_cell0.67995229
144MP0002277_abnormal_respiratory_mucosa0.66600290
145MP0003119_abnormal_digestive_system0.66356731
146MP0001984_abnormal_olfaction0.64899827
147MP0005084_abnormal_gallbladder_morpholo0.64033163
148MP0001919_abnormal_reproductive_system0.63665703
149MP0000685_abnormal_immune_system0.61961962
150MP0002169_no_abnormal_phenotype0.61545991
151MP0005253_abnormal_eye_physiology0.61154773

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.54544871
2Abnormal number of erythroid precursors (HP:0012131)5.44809897
3Severe combined immunodeficiency (HP:0004430)4.69354298
4Reticulocytopenia (HP:0001896)4.36424560
5Cerebral hypomyelination (HP:0006808)4.04599413
6Hepatocellular necrosis (HP:0001404)3.95452177
7Elevated erythrocyte sedimentation rate (HP:0003565)3.93230713
8Mitochondrial inheritance (HP:0001427)3.90078776
9Increased hepatocellular lipid droplets (HP:0006565)3.87801583
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.86080698
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.84303674
12Aplastic anemia (HP:0001915)3.79884524
13Hyperalaninemia (HP:0003348)3.79771890
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.79771890
15Abnormality of alanine metabolism (HP:0010916)3.79771890
16Combined immunodeficiency (HP:0005387)3.79728011
17Decreased activity of mitochondrial respiratory chain (HP:0008972)3.73381125
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.73381125
19Progressive muscle weakness (HP:0003323)3.65558412
20Macrocytic anemia (HP:0001972)3.64230784
21Lipid accumulation in hepatocytes (HP:0006561)3.56607865
22Thyroiditis (HP:0100646)3.53738233
23Pallor (HP:0000980)3.52400710
24T lymphocytopenia (HP:0005403)3.51417105
25IgG deficiency (HP:0004315)3.47053715
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.46726601
27Oral leukoplakia (HP:0002745)3.39092031
28Microretrognathia (HP:0000308)3.36641629
29Increased serum lactate (HP:0002151)3.27821208
30Increased CSF lactate (HP:0002490)3.24235680
31Acute necrotizing encephalopathy (HP:0006965)3.22870100
32Severe visual impairment (HP:0001141)3.22703130
33Hepatic necrosis (HP:0002605)3.19834886
34Increased intramyocellular lipid droplets (HP:0012240)3.18471480
35Absent rod-and cone-mediated responses on ERG (HP:0007688)3.13800279
36Abnormality of T cell number (HP:0011839)3.12898328
37Birth length less than 3rd percentile (HP:0003561)3.10124771
38Breast hypoplasia (HP:0003187)3.08812921
39Abnormal mitochondria in muscle tissue (HP:0008316)3.08462606
40Stomatitis (HP:0010280)3.06493940
41Myositis (HP:0100614)3.02041026
42Exertional dyspnea (HP:0002875)2.96723162
43Rough bone trabeculation (HP:0100670)2.94582311
44Agammaglobulinemia (HP:0004432)2.92473273
45Abnormality of eosinophils (HP:0001879)2.83892100
46Emotional lability (HP:0000712)2.82283022
47Panhypogammaglobulinemia (HP:0003139)2.80029291
48Increased muscle lipid content (HP:0009058)2.74936029
49Abnormality of T cells (HP:0002843)2.72684621
50Dicarboxylic aciduria (HP:0003215)2.70391145
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.70391145
52Trismus (HP:0000211)2.70182157
53Recurrent cutaneous fungal infections (HP:0011370)2.68793015
54Chronic mucocutaneous candidiasis (HP:0002728)2.68793015
55Delusions (HP:0000746)2.68512894
56Recurrent fungal infections (HP:0002841)2.67961291
57Renal Fanconi syndrome (HP:0001994)2.66142950
58Encephalitis (HP:0002383)2.63658706
59Carpal bone hypoplasia (HP:0001498)2.61010936
60Lactic acidosis (HP:0003128)2.59887337
61Methylmalonic aciduria (HP:0012120)2.58503250
62Acute encephalopathy (HP:0006846)2.56433084
63Eosinophilia (HP:0001880)2.55343065
64Abnormality of B cell number (HP:0010975)2.54744605
65Secondary amenorrhea (HP:0000869)2.54709169
66Patellar aplasia (HP:0006443)2.51753706
67B lymphocytopenia (HP:0010976)2.50387653
68Granulocytopenia (HP:0001913)2.49547746
69CNS hypomyelination (HP:0003429)2.49433575
70Abnormal rod and cone electroretinograms (HP:0008323)2.47653485
71Leukocytosis (HP:0001974)2.46664266
72Generalized aminoaciduria (HP:0002909)2.45878569
73Aplasia/Hypoplasia of the patella (HP:0006498)2.44050438
74Type I transferrin isoform profile (HP:0003642)2.42609505
75Orchitis (HP:0100796)2.41112954
76Unsteady gait (HP:0002317)2.40891979
77Overlapping toe (HP:0001845)2.39706794
78CNS demyelination (HP:0007305)2.38469668
79Nasal polyposis (HP:0100582)2.37910579
80Hypoproteinemia (HP:0003075)2.37483965
81Retrobulbar optic neuritis (HP:0100654)2.35255672
82Optic neuritis (HP:0100653)2.35255672
83Meningitis (HP:0001287)2.34562370
84Aplasia/hypoplasia of the uterus (HP:0008684)2.31653397
85Cerebral palsy (HP:0100021)2.31236435
86Progressive macrocephaly (HP:0004481)2.30700714
87Respiratory difficulties (HP:0002880)2.28912768
88Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.28634462
89Abnormal delayed hypersensitivity skin test (HP:0002963)2.24328227
90Exercise intolerance (HP:0003546)2.22724304
913-Methylglutaconic aciduria (HP:0003535)2.22129112
92Methylmalonic acidemia (HP:0002912)2.21349378
93Increased IgM level (HP:0003496)2.20000901
94Abnormal protein N-linked glycosylation (HP:0012347)2.19964524
95Abnormal protein glycosylation (HP:0012346)2.19964524
96Abnormal glycosylation (HP:0012345)2.19964524
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.19964524
98Pancytopenia (HP:0001876)2.19711135
99Selective tooth agenesis (HP:0001592)2.19042104
100Recurrent viral infections (HP:0004429)2.18877580
101Abnormality of the anterior horn cell (HP:0006802)2.16783208
102Degeneration of anterior horn cells (HP:0002398)2.16783208
103Delayed CNS myelination (HP:0002188)2.14984310
104Respiratory failure (HP:0002878)2.13990850
105Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13561422
106Premature ovarian failure (HP:0008209)2.13046180
107Abnormality of T cell physiology (HP:0011840)2.09974633
108Concave nail (HP:0001598)2.09833104
109Abnormality of the heme biosynthetic pathway (HP:0010472)2.07832298
110Abnormality of the nasal mucosa (HP:0000433)2.07089021
111Retinal dysplasia (HP:0007973)2.06356080
112Failure to thrive in infancy (HP:0001531)2.04743990
113Congenital stationary night blindness (HP:0007642)2.03421392
114Optic disc pallor (HP:0000543)2.01195320
115Mediastinal lymphadenopathy (HP:0100721)1.99983012
116Limb dystonia (HP:0002451)1.97979446
117Abnormality of the prostate (HP:0008775)1.96408911
118Poor head control (HP:0002421)1.96363637
119Postnatal microcephaly (HP:0005484)1.96030031
120Obstructive lung disease (HP:0006536)1.94819306
121Chronic obstructive pulmonary disease (HP:0006510)1.94819306
122Split foot (HP:0001839)1.94811801
123Albinism (HP:0001022)1.94762472
124Abnormality of glycolysis (HP:0004366)1.94687767
125Increased serum pyruvate (HP:0003542)1.94687767
126Absent thumb (HP:0009777)1.94261509
127Neoplasm of the pancreas (HP:0002894)1.93749553
128Abnormality of macrophages (HP:0004311)1.92856350
129Abnormal hemoglobin (HP:0011902)1.91143758
130Cerebral edema (HP:0002181)1.91133555
131Recurrent abscess formation (HP:0002722)1.90916137
132Reduced antithrombin III activity (HP:0001976)1.90098909
133Ragged-red muscle fibers (HP:0003200)1.89776604
134Progressive microcephaly (HP:0000253)1.89213907
135Triphalangeal thumb (HP:0001199)1.87731803
136Muscle fiber atrophy (HP:0100295)1.87451604
137Amyotrophic lateral sclerosis (HP:0007354)1.87090600
138Abnormality of lateral ventricle (HP:0030047)1.86623573
139Abnormal trabecular bone morphology (HP:0100671)1.86032199
140Recurrent skin infections (HP:0001581)1.85602235
141Premature graying of hair (HP:0002216)1.85438800
142Lethargy (HP:0001254)1.85092631
143Horseshoe kidney (HP:0000085)1.84245684
144Ketosis (HP:0001946)1.84069962
145Slender long bone (HP:0003100)1.83552904
146Recurrent bacterial skin infections (HP:0005406)1.82177305
147Autoimmune thrombocytopenia (HP:0001973)1.82073769
148Acute hepatic failure (HP:0006554)1.81223090
149Hypoplasia of the thymus (HP:0000778)1.80717443
150Constricted visual fields (HP:0001133)1.80712878
151Hypoplasia of the uterus (HP:0000013)1.80648149
152Atrophy/Degeneration involving motor neurons (HP:0007373)1.80584343
153Pancreatic cysts (HP:0001737)1.79784627
154Bony spicule pigmentary retinopathy (HP:0007737)1.79332779
155Personality changes (HP:0000751)1.79059112
156Abnormality of the preputium (HP:0100587)1.78212889
157Autoimmune hemolytic anemia (HP:0001890)1.77905958
158Pendular nystagmus (HP:0012043)1.77539935
159Cleft eyelid (HP:0000625)1.72884003
160Type 2 muscle fiber atrophy (HP:0003554)1.72713625
161Meckel diverticulum (HP:0002245)1.71359013
162Cerebellar dysplasia (HP:0007033)1.71063518
163Abnormality of the ileum (HP:0001549)1.70655528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.43245007
2NME24.22189571
3TXK4.20669939
4TESK24.19213559
5TLK14.13823467
6STK163.34630237
7VRK23.34587434
8EIF2AK13.17906540
9WEE13.00865522
10DYRK32.74467380
11TAOK32.34880362
12PIM22.25027664
13TESK12.03098519
14NEK22.02413915
15BCKDK2.00041515
16MAPKAPK31.93972535
17SRPK11.91800077
18ZAK1.85622192
19MAP3K111.85231299
20ACVR1B1.76311320
21KDR1.72465692
22CDK191.69389007
23ARAF1.64914943
24AURKA1.64559821
25MAP4K21.62520401
26GRK61.55602951
27BRAF1.53508683
28FES1.52806079
29NME11.45199599
30IKBKE1.43626627
31KIT1.42697693
32DYRK21.40347451
33VRK11.39179244
34LATS21.35674991
35SCYL21.34459002
36LIMK11.32468016
37EIF2AK31.32346276
38PLK11.27720542
39MAP2K21.27378996
40IKBKB1.25373507
41GRK71.21782416
42TRIM281.19705193
43NUAK11.19502855
44PAK41.19449148
45RPS6KA41.18034207
46ADRBK21.17764650
47SYK1.15586936
48MAP3K121.15027773
49GRK11.14794547
50ITK1.13407451
51BLK1.13181447
52TAOK21.12250672
53PASK1.10479926
54MAP2K71.07661855
55MAPKAPK51.07280046
56ERN11.06011389
57RPS6KA50.98535125
58LCK0.96775235
59RPS6KB20.96323515
60PAK10.93608635
61CDK70.93099228
62TTK0.91730627
63WNK30.88283986
64CDC70.87701255
65DAPK30.87350656
66JAK30.86213786
67AURKB0.84953467
68CSNK1A1L0.83975195
69CSF1R0.83057525
70TNK20.82563076
71MUSK0.82019440
72MARK30.81850885
73TEC0.80641511
74LYN0.80401181
75PLK40.78072107
76CHEK20.77111219
77MAP3K100.75190220
78TYK20.71475536
79TIE10.71466300
80UHMK10.70931125
81CSNK1G20.70585643
82MINK10.69416804
83RAF10.68797660
84ZAP700.67868171
85BRSK20.67789227
86PBK0.67587523
87GRK50.66962579
88MAPK150.66560108
89CDK40.64572366
90MAPK130.63118237
91IRAK10.62573091
92PRKCQ0.62281040
93BTK0.61513543
94FLT30.60684262
95STK100.60539863
96KSR10.60286752
97MAP3K80.58977836
98MST40.58240358
99ABL20.57261958
100FRK0.57076850
101ERBB30.55218138
102MAP3K140.52586160
103BCR0.51990601
104IRAK20.51944847
105ATR0.51258226
106CDK140.51010546
107DAPK10.50708162
108ADRBK10.49619875
109SIK30.49258433
110PRKCI0.48260193
111RIPK40.48018585
112CSNK1G30.47825200
113BRSK10.47402586
114CCNB10.46395451
115NEK10.45972964
116PINK10.45761352
117DYRK1B0.45642223
118CSK0.45522717
119MAPK110.45367903
120MAP3K40.44727548
121NLK0.42965546
122MAP2K30.42901639
123CSNK1G10.42712517
124CSNK2A20.42075373
125CDK80.41550444
126CDK11A0.40912211
127CSNK2A10.40207573
128CDK180.39031492
129PAK60.37925175
130EPHA20.37461658
131PKN10.37055505
132HCK0.36717755
133MKNK20.35412087
134CDK150.34373824
135MKNK10.33231238
136EIF2AK20.32309203
137CSNK1A10.31788587
138ICK0.31757325
139BMPR1B0.31403990
140CHUK0.30455229
141KSR20.29115649
142ABL10.28839272
143TBK10.28039414
144MAP3K90.27341380
145PIM10.26492521
146HIPK20.25180702
147MAP4K10.24313114
148IRAK40.22040383
149MAP3K50.21837601
150MAP2K60.20595820
151CDK20.20558731
152CHEK10.19037569
153PHKG20.18688744

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.48920458
2RNA polymerase_Homo sapiens_hsa030204.27985579
3Proteasome_Homo sapiens_hsa030504.26015115
4DNA replication_Homo sapiens_hsa030303.78534819
5Spliceosome_Homo sapiens_hsa030403.09935436
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09906941
7Pyrimidine metabolism_Homo sapiens_hsa002402.96266447
8Mismatch repair_Homo sapiens_hsa034302.78512701
9Parkinsons disease_Homo sapiens_hsa050122.68106367
10Oxidative phosphorylation_Homo sapiens_hsa001902.64915975
11RNA transport_Homo sapiens_hsa030132.40020862
12Base excision repair_Homo sapiens_hsa034102.37356303
13Nucleotide excision repair_Homo sapiens_hsa034202.34489838
14Sulfur relay system_Homo sapiens_hsa041222.29122365
15Autoimmune thyroid disease_Homo sapiens_hsa053202.28485585
16Homologous recombination_Homo sapiens_hsa034402.26354904
17Huntingtons disease_Homo sapiens_hsa050162.18639300
18Graft-versus-host disease_Homo sapiens_hsa053322.16593021
19Allograft rejection_Homo sapiens_hsa053302.15275391
20Protein export_Homo sapiens_hsa030601.97438549
21Cell cycle_Homo sapiens_hsa041101.93344764
22Type I diabetes mellitus_Homo sapiens_hsa049401.87952199
23Folate biosynthesis_Homo sapiens_hsa007901.70828084
24Basal transcription factors_Homo sapiens_hsa030221.69580099
25Fanconi anemia pathway_Homo sapiens_hsa034601.67519491
26Purine metabolism_Homo sapiens_hsa002301.61423660
27Alzheimers disease_Homo sapiens_hsa050101.59252852
28Sulfur metabolism_Homo sapiens_hsa009201.58808254
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57074172
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.54943179
31Rheumatoid arthritis_Homo sapiens_hsa053231.53380569
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52914738
33RNA degradation_Homo sapiens_hsa030181.42627907
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42340976
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41278530
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40502766
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24929950
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19367884
39Asthma_Homo sapiens_hsa053101.18291337
40NOD-like receptor signaling pathway_Homo sapiens_hsa046211.17770610
41Viral myocarditis_Homo sapiens_hsa054161.14764798
42Pentose phosphate pathway_Homo sapiens_hsa000301.13901493
43Peroxisome_Homo sapiens_hsa041461.12547748
44Cardiac muscle contraction_Homo sapiens_hsa042601.10253894
45p53 signaling pathway_Homo sapiens_hsa041151.08301417
46Epstein-Barr virus infection_Homo sapiens_hsa051691.06144419
47Fatty acid elongation_Homo sapiens_hsa000621.04100715
48mRNA surveillance pathway_Homo sapiens_hsa030151.03713699
49Non-homologous end-joining_Homo sapiens_hsa034501.01668367
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00894639
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.00819041
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00615064
53Systemic lupus erythematosus_Homo sapiens_hsa053220.96966044
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.96852082
55Collecting duct acid secretion_Homo sapiens_hsa049660.95547387
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91078375
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90420627
58Measles_Homo sapiens_hsa051620.89173944
59Oocyte meiosis_Homo sapiens_hsa041140.88091165
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87493180
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85703577
62Regulation of autophagy_Homo sapiens_hsa041400.84761901
63T cell receptor signaling pathway_Homo sapiens_hsa046600.84726736
64Leishmaniasis_Homo sapiens_hsa051400.81249581
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81100356
66Shigellosis_Homo sapiens_hsa051310.80142791
67Butanoate metabolism_Homo sapiens_hsa006500.78286857
68One carbon pool by folate_Homo sapiens_hsa006700.78148591
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77871431
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77693606
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76376962
72N-Glycan biosynthesis_Homo sapiens_hsa005100.75679886
73Alcoholism_Homo sapiens_hsa050340.73153253
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71242306
75Glutathione metabolism_Homo sapiens_hsa004800.69763404
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68392850
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.65469560
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62445324
79Metabolic pathways_Homo sapiens_hsa011000.62026821
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61939758
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59594971
82Tuberculosis_Homo sapiens_hsa051520.59311841
83Legionellosis_Homo sapiens_hsa051340.56805263
84Thyroid cancer_Homo sapiens_hsa052160.52907191
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52661842
86Fructose and mannose metabolism_Homo sapiens_hsa000510.52565676
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52447359
88Biosynthesis of amino acids_Homo sapiens_hsa012300.51785391
89Phagosome_Homo sapiens_hsa041450.51673744
90Staphylococcus aureus infection_Homo sapiens_hsa051500.51155420
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50054120
92Bladder cancer_Homo sapiens_hsa052190.49771788
93Nitrogen metabolism_Homo sapiens_hsa009100.43004255
94Osteoclast differentiation_Homo sapiens_hsa043800.42253258
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.41033329
96Viral carcinogenesis_Homo sapiens_hsa052030.40784741
97Primary immunodeficiency_Homo sapiens_hsa053400.39881079
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37141076
99Herpes simplex infection_Homo sapiens_hsa051680.37052695
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36112177
101Phototransduction_Homo sapiens_hsa047440.35926305
102Arachidonic acid metabolism_Homo sapiens_hsa005900.33880384
103Propanoate metabolism_Homo sapiens_hsa006400.33735250
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.32252129
105Influenza A_Homo sapiens_hsa051640.31891945
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31341378
107Carbon metabolism_Homo sapiens_hsa012000.31106011
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29904613
109Linoleic acid metabolism_Homo sapiens_hsa005910.27886366
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.27876287
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.27703209
112Sphingolipid metabolism_Homo sapiens_hsa006000.24624912
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.22464350
114Antigen processing and presentation_Homo sapiens_hsa046120.21883158
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21538302
116VEGF signaling pathway_Homo sapiens_hsa043700.20539421
117Arginine and proline metabolism_Homo sapiens_hsa003300.19963459
118Galactose metabolism_Homo sapiens_hsa000520.19925799
119HTLV-I infection_Homo sapiens_hsa051660.19616364
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18689186
121Vitamin B6 metabolism_Homo sapiens_hsa007500.17649844
122Pyruvate metabolism_Homo sapiens_hsa006200.16401430
123Endocytosis_Homo sapiens_hsa041440.16043588
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15984252
125Ether lipid metabolism_Homo sapiens_hsa005650.15887114
126Vibrio cholerae infection_Homo sapiens_hsa051100.15827686
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.15745173
128Apoptosis_Homo sapiens_hsa042100.14275829
129Synaptic vesicle cycle_Homo sapiens_hsa047210.11867611
130Notch signaling pathway_Homo sapiens_hsa043300.09162831
131Selenocompound metabolism_Homo sapiens_hsa004500.08711328
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.08056917
133Other glycan degradation_Homo sapiens_hsa005110.07931021
134Acute myeloid leukemia_Homo sapiens_hsa052210.07327776
135Hematopoietic cell lineage_Homo sapiens_hsa046400.07273649
136Renin-angiotensin system_Homo sapiens_hsa046140.04222271
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.03225253
138Salmonella infection_Homo sapiens_hsa051320.01988753
139alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0024516
140Transcriptional misregulation in cancer_Homo sapiens_hsa05202-0.0008340

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