TBCCD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.46725081
2L-phenylalanine catabolic process (GO:0006559)5.46725081
3DNA deamination (GO:0045006)5.14415723
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.13963232
5L-phenylalanine metabolic process (GO:0006558)5.13963232
6serine family amino acid biosynthetic process (GO:0009070)4.86204962
7cysteine metabolic process (GO:0006534)4.73437819
8glycine metabolic process (GO:0006544)4.70915491
9aromatic amino acid family catabolic process (GO:0009074)4.57021725
10L-serine metabolic process (GO:0006563)4.51224094
11fucose catabolic process (GO:0019317)4.44926515
12L-fucose metabolic process (GO:0042354)4.44926515
13L-fucose catabolic process (GO:0042355)4.44926515
14protoporphyrinogen IX metabolic process (GO:0046501)4.31473870
15protoporphyrinogen IX biosynthetic process (GO:0006782)4.21746556
16serine family amino acid metabolic process (GO:0009069)4.21591034
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.13621069
18serine family amino acid catabolic process (GO:0009071)4.08187586
19tryptophan catabolic process (GO:0006569)3.81281947
20indole-containing compound catabolic process (GO:0042436)3.81281947
21indolalkylamine catabolic process (GO:0046218)3.81281947
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.80618734
23alpha-linolenic acid metabolic process (GO:0036109)3.79629852
24glyoxylate metabolic process (GO:0046487)3.79557113
25homocysteine metabolic process (GO:0050667)3.79492156
26amino-acid betaine metabolic process (GO:0006577)3.76382881
27bile acid biosynthetic process (GO:0006699)3.75529938
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.72143637
29lysine metabolic process (GO:0006553)3.70482660
30lysine catabolic process (GO:0006554)3.70482660
31DNA double-strand break processing (GO:0000729)3.68985688
32proteasome assembly (GO:0043248)3.66827198
33respiratory chain complex IV assembly (GO:0008535)3.66794997
34tryptophan metabolic process (GO:0006568)3.63527007
35aspartate family amino acid catabolic process (GO:0009068)3.58166388
36replication fork processing (GO:0031297)3.57187914
37urea cycle (GO:0000050)3.53352619
38urea metabolic process (GO:0019627)3.53352619
39protein-cofactor linkage (GO:0018065)3.52264412
40alpha-amino acid catabolic process (GO:1901606)3.51017842
41kynurenine metabolic process (GO:0070189)3.49640701
42folic acid-containing compound biosynthetic process (GO:0009396)3.48363335
43establishment of protein localization to mitochondrial membrane (GO:0090151)3.47911628
44preassembly of GPI anchor in ER membrane (GO:0016254)3.46767613
45intestinal cholesterol absorption (GO:0030299)3.45776984
46one-carbon metabolic process (GO:0006730)3.42748306
47aromatic amino acid family metabolic process (GO:0009072)3.42188675
48sulfur amino acid catabolic process (GO:0000098)3.41401946
49behavioral response to nicotine (GO:0035095)3.40394274
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.40386407
51somatic hypermutation of immunoglobulin genes (GO:0016446)3.40386407
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37876592
53triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.36279190
54nucleobase biosynthetic process (GO:0046112)3.36144870
55RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.35941940
56cellular modified amino acid catabolic process (GO:0042219)3.35069912
57synapsis (GO:0007129)3.35027481
58nitrogen cycle metabolic process (GO:0071941)3.34892241
59water-soluble vitamin biosynthetic process (GO:0042364)3.29664262
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27677140
61sulfur amino acid biosynthetic process (GO:0000097)3.27280132
62tetrahydrofolate metabolic process (GO:0046653)3.26252862
63mannosylation (GO:0097502)3.25889182
64protein complex biogenesis (GO:0070271)3.25760259
65cytochrome complex assembly (GO:0017004)3.24891310
66platelet dense granule organization (GO:0060155)3.24837413
67high-density lipoprotein particle remodeling (GO:0034375)3.22086952
68bile acid metabolic process (GO:0008206)3.21550327
69L-methionine salvage (GO:0071267)3.21198613
70L-methionine biosynthetic process (GO:0071265)3.21198613
71amino acid salvage (GO:0043102)3.21198613
72folic acid metabolic process (GO:0046655)3.21174155
73cellular amino acid catabolic process (GO:0009063)3.20111563
74piRNA metabolic process (GO:0034587)3.17849886
75regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.17408851
76regulation of mitotic spindle checkpoint (GO:1903504)3.17408851
77peptidyl-histidine modification (GO:0018202)3.15961587
78S-adenosylmethionine metabolic process (GO:0046500)3.15054975
79recombinational repair (GO:0000725)3.13784239
80protein K6-linked ubiquitination (GO:0085020)3.13681693
81amine catabolic process (GO:0009310)3.13639511
82cellular biogenic amine catabolic process (GO:0042402)3.13639511
83heme biosynthetic process (GO:0006783)3.13578640
84mitochondrial respiratory chain complex assembly (GO:0033108)3.12067567
85pseudouridine synthesis (GO:0001522)3.11653993
86coenzyme catabolic process (GO:0009109)3.11449066
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.10127357
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.10127357
89tyrosine metabolic process (GO:0006570)3.09330514
90alpha-amino acid biosynthetic process (GO:1901607)3.09095332
91double-strand break repair via homologous recombination (GO:0000724)3.09007997
92folic acid-containing compound metabolic process (GO:0006760)3.08519671
93maturation of 5.8S rRNA (GO:0000460)3.06906893
94aspartate family amino acid metabolic process (GO:0009066)3.04037436
95cullin deneddylation (GO:0010388)3.03807600
96heme transport (GO:0015886)3.02430453
97very-low-density lipoprotein particle assembly (GO:0034379)3.02284535
98peroxisome fission (GO:0016559)3.00853399
99purine nucleobase biosynthetic process (GO:0009113)3.00743392
100mitochondrial RNA metabolic process (GO:0000959)3.00325445
101somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.99955761
102isotype switching (GO:0045190)2.99955761
103somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.99955761
104resolution of meiotic recombination intermediates (GO:0000712)2.99667321
105DNA catabolic process, exonucleolytic (GO:0000738)2.99087637
106negative regulation of fibrinolysis (GO:0051918)2.98534575
107DNA replication checkpoint (GO:0000076)2.98372995
108DNA unwinding involved in DNA replication (GO:0006268)2.97736708
109regulation of protein activation cascade (GO:2000257)2.97074067
110protein deneddylation (GO:0000338)2.96793838
111neural tube formation (GO:0001841)2.95629755
112cytidine deamination (GO:0009972)2.93764365
113cytidine metabolic process (GO:0046087)2.93764365
114cytidine catabolic process (GO:0006216)2.93764365
115pteridine-containing compound biosynthetic process (GO:0042559)2.92615644
116mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92037747
117mitochondrial respiratory chain complex I assembly (GO:0032981)2.92037747
118NADH dehydrogenase complex assembly (GO:0010257)2.92037747
119heme metabolic process (GO:0042168)2.90465898
120carnitine metabolic process (GO:0009437)2.89407054
121cofactor catabolic process (GO:0051187)2.89151907
122maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.87823485
123protein carboxylation (GO:0018214)2.86258060
124peptidyl-glutamic acid carboxylation (GO:0017187)2.86258060
125pteridine-containing compound metabolic process (GO:0042558)2.85213889
126aldehyde catabolic process (GO:0046185)2.84940733
127regulation of fibrinolysis (GO:0051917)2.84550432
128cellular ketone body metabolic process (GO:0046950)2.84504517
129meiotic chromosome segregation (GO:0045132)2.84216693
130protein neddylation (GO:0045116)2.83724735
131carboxylic acid catabolic process (GO:0046395)2.83369519
132organic acid catabolic process (GO:0016054)2.83369519
133cellular amino acid biosynthetic process (GO:0008652)2.82472538
134porphyrin-containing compound biosynthetic process (GO:0006779)2.81984179
135L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.81980766
136regulation of nuclear cell cycle DNA replication (GO:0033262)2.81736132
137response to pheromone (GO:0019236)2.81658161
138reverse cholesterol transport (GO:0043691)2.77935191
139tRNA processing (GO:0008033)2.76196791
140DNA ligation (GO:0006266)2.76108558
141protein-lipid complex remodeling (GO:0034368)2.75462392
142macromolecular complex remodeling (GO:0034367)2.75462392
143plasma lipoprotein particle remodeling (GO:0034369)2.75462392
144complement activation, alternative pathway (GO:0006957)2.74947022
145regulation of complement activation (GO:0030449)2.74772800
146rRNA catabolic process (GO:0016075)2.73630772
147indolalkylamine metabolic process (GO:0006586)2.73171804
148branched-chain amino acid catabolic process (GO:0009083)2.72260074
149plasma lipoprotein particle assembly (GO:0034377)2.72111797
150rRNA modification (GO:0000154)2.71562333
151NAD biosynthetic process (GO:0009435)2.70348053
152termination of RNA polymerase III transcription (GO:0006386)2.69893108
153transcription elongation from RNA polymerase III promoter (GO:0006385)2.69893108
154histone H2A acetylation (GO:0043968)2.69661391
155pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.69629277
156centriole replication (GO:0007099)2.69008283
157sulfur amino acid metabolic process (GO:0000096)2.68730608
158response to nitrosative stress (GO:0051409)2.68358460
159disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.67287588
160killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.67287588
161DNA-dependent DNA replication (GO:0006261)2.66775390
162ubiquinone metabolic process (GO:0006743)2.66565408
163fatty acid beta-oxidation (GO:0006635)2.66407647
164mitotic metaphase plate congression (GO:0007080)2.65219437
165urate metabolic process (GO:0046415)2.65048052
166epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64335210
167DNA strand elongation involved in DNA replication (GO:0006271)2.64069493
168reciprocal DNA recombination (GO:0035825)2.63324828
169reciprocal meiotic recombination (GO:0007131)2.63324828
170coenzyme A metabolic process (GO:0015936)2.62736419
171ATP synthesis coupled proton transport (GO:0015986)2.62518848
172energy coupled proton transport, down electrochemical gradient (GO:0015985)2.62518848
173ubiquinone biosynthetic process (GO:0006744)2.62392329
174porphyrin-containing compound metabolic process (GO:0006778)2.62349424
175nicotinamide nucleotide biosynthetic process (GO:0019359)2.61399329
176pyridine nucleotide biosynthetic process (GO:0019363)2.61399329
177intracellular protein transmembrane import (GO:0044743)2.61384728
178tRNA metabolic process (GO:0006399)2.60828277
179iron-sulfur cluster assembly (GO:0016226)2.60262395
180metallo-sulfur cluster assembly (GO:0031163)2.60262395
181ketone body metabolic process (GO:1902224)2.60170691
182negative regulation of telomere maintenance (GO:0032205)2.59932190
183protein polyglutamylation (GO:0018095)2.58975121
184pyrimidine ribonucleoside catabolic process (GO:0046133)2.58426677
185nonmotile primary cilium assembly (GO:0035058)2.57910571
186mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.57827234
187signal peptide processing (GO:0006465)2.57348828
188intra-S DNA damage checkpoint (GO:0031573)2.51890503
189somatic diversification of immunoglobulins (GO:0016445)2.51506294
190DNA methylation involved in gamete generation (GO:0043046)2.50919644
191male meiosis I (GO:0007141)2.50635960
192chromatin remodeling at centromere (GO:0031055)2.49397647
193DNA demethylation (GO:0080111)2.47665916
194photoreceptor cell maintenance (GO:0045494)2.47269742
195DNA recombination (GO:0006310)2.47116873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.69291732
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.05040451
3ZNF274_21170338_ChIP-Seq_K562_Hela3.83777810
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.54734965
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.44645513
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.41007239
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.31359448
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.24017821
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.21854531
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.13176006
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.12366542
12PPARA_22158963_ChIP-Seq_LIVER_Mouse3.11953750
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.82331033
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.76366158
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66745175
16VDR_22108803_ChIP-Seq_LS180_Human2.51396447
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.49755304
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.48912310
19IGF1R_20145208_ChIP-Seq_DFB_Human2.46907721
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46411281
21* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43772095
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39902116
23LXR_22158963_ChIP-Seq_LIVER_Mouse2.36940207
24GATA1_22025678_ChIP-Seq_K562_Human2.36222823
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.30791221
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.27205482
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.26519318
28ETS1_20019798_ChIP-Seq_JURKAT_Human2.22077453
29EWS_26573619_Chip-Seq_HEK293_Human2.21965644
30AR_21909140_ChIP-Seq_LNCAP_Human2.11268402
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09129872
32POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06991474
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00371677
34* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94342883
35GBX2_23144817_ChIP-Seq_PC3_Human1.91831610
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89230843
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88902319
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.88760368
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88572088
40* SRF_21415370_ChIP-Seq_HL-1_Mouse1.86968040
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84246871
42FUS_26573619_Chip-Seq_HEK293_Human1.83144963
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82781479
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79533275
45E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79146988
46VDR_23849224_ChIP-Seq_CD4+_Human1.75485117
47DCP1A_22483619_ChIP-Seq_HELA_Human1.75423190
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72073812
49TAF15_26573619_Chip-Seq_HEK293_Human1.70727346
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66575675
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65997705
52FOXP3_21729870_ChIP-Seq_TREG_Human1.64285367
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63822660
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61502577
55ER_23166858_ChIP-Seq_MCF-7_Human1.57891851
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55382694
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55294208
58* GABP_19822575_ChIP-Seq_HepG2_Human1.54822151
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54605843
60XRN2_22483619_ChIP-Seq_HELA_Human1.51657418
61P300_19829295_ChIP-Seq_ESCs_Human1.51468134
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49306140
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49256981
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48970688
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47413639
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47197067
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46772015
68TP53_22573176_ChIP-Seq_HFKS_Human1.45076650
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43804363
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43590351
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.42512829
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34767149
73MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34685703
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30589325
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30146038
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25947133
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24781567
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24722144
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21529528
80FOXA1_25329375_ChIP-Seq_VCAP_Human1.21141621
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21141621
82KDM5A_27292631_Chip-Seq_BREAST_Human1.20403407
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19015202
84FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17956862
85AR_20517297_ChIP-Seq_VCAP_Human1.17915306
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16848363
87SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15380278
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13472163
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13095494
90CBP_20019798_ChIP-Seq_JUKART_Human1.13095494
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13025474
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12555590
93NANOG_19829295_ChIP-Seq_ESCs_Human1.11977045
94SOX2_19829295_ChIP-Seq_ESCs_Human1.11977045
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11022993
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10210368
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.09404941
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09379006
99FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09218960
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08819747
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.06900512
102GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06287578
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05087058
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03447541
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03289325
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03189974
107ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02994102
108PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02654268
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.02379767
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01259591
111YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01044745
112KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99822012
113NCOR_22424771_ChIP-Seq_293T_Human0.98745867
114BCAT_22108803_ChIP-Seq_LS180_Human0.97890629
115TFEB_21752829_ChIP-Seq_HELA_Human0.97691415
116TTF2_22483619_ChIP-Seq_HELA_Human0.97175997
117TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97016055
118YY1_21170310_ChIP-Seq_MESCs_Mouse0.96999196
119HOXB7_26014856_ChIP-Seq_BT474_Human0.96743190
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96563235
121AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95449967
122PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95446332
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95305377
124IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95297440
125GATA3_26560356_Chip-Seq_TH2_Human0.95149759
126IRF1_19129219_ChIP-ChIP_H3396_Human0.95134317
127NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95096002
128STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94843412
129POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93720519
130GATA3_21878914_ChIP-Seq_MCF-7_Human0.93160418
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92317621
132STAT3_23295773_ChIP-Seq_U87_Human0.91102119
133FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91086410
134AR_25329375_ChIP-Seq_VCAP_Human0.90941292
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89901952
136SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89728071
137CIITA_25753668_ChIP-Seq_RAJI_Human0.88954795
138TCF4_22108803_ChIP-Seq_LS180_Human0.87670187
139EGR1_19374776_ChIP-ChIP_THP-1_Human0.86826634
140CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85749380
141KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85686368
142KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.84468423
143TBX5_21415370_ChIP-Seq_HL-1_Mouse0.82248215
144SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82125761
145NOTCH1_21737748_ChIP-Seq_TLL_Human0.80637524
146PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80609841
147MYC_18940864_ChIP-ChIP_HL60_Human0.80011162
148POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.78859714
149NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77664226
150ELK1_19687146_ChIP-ChIP_HELA_Human0.77384867
151* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.76763508
152SCL_19346495_ChIP-Seq_HPC-7_Human0.75744139
153POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.72322267
154ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.71949606
155IRF8_21731497_ChIP-ChIP_J774_Mouse0.69603908
156CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.68394424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.58654402
2MP0005360_urolithiasis5.19588783
3MP0003806_abnormal_nucleotide_metabolis5.02069416
4MP0005365_abnormal_bile_salt4.75865372
5MP0005085_abnormal_gallbladder_physiolo4.53015806
6MP0008877_abnormal_DNA_methylation3.99064412
7MP0003656_abnormal_erythrocyte_physiolo3.45701598
8MP0008875_abnormal_xenobiotic_pharmacok3.18880621
9MP0001666_abnormal_nutrient_absorption2.98851055
10MP0005083_abnormal_biliary_tract2.77093499
11MP0002102_abnormal_ear_morphology2.59962817
12MP0009840_abnormal_foam_cell2.59703960
13MP0003693_abnormal_embryo_hatching2.44763767
14MP0005332_abnormal_amino_acid2.42201139
15MP0003787_abnormal_imprinting2.36545644
16MP0006072_abnormal_retinal_apoptosis2.31795710
17MP0005551_abnormal_eye_electrophysiolog2.31349972
18MP0000372_irregular_coat_pigmentation2.23304487
19MP0010094_abnormal_chromosome_stability2.22621235
20MP0004147_increased_porphyrin_level2.20882926
21MP0005253_abnormal_eye_physiology2.19897134
22MP0003111_abnormal_nucleus_morphology2.16863746
23MP0010329_abnormal_lipoprotein_level2.15845727
24MP0003186_abnormal_redox_activity2.12491492
25MP0003252_abnormal_bile_duct2.12376580
26MP0001986_abnormal_taste_sensitivity2.05601557
27MP0003646_muscle_fatigue2.04937267
28MP0001984_abnormal_olfaction2.04813246
29MP0003868_abnormal_feces_composition1.99036732
30MP0001764_abnormal_homeostasis1.98604386
31MP0005220_abnormal_exocrine_pancreas1.95877881
32MP0008789_abnormal_olfactory_epithelium1.85843416
33MP0004957_abnormal_blastocyst_morpholog1.84851337
34MP0002837_dystrophic_cardiac_calcinosis1.80519535
35MP0008872_abnormal_physiological_respon1.75377915
36MP0006036_abnormal_mitochondrial_physio1.74991942
37MP0000609_abnormal_liver_physiology1.74774790
38MP0006292_abnormal_olfactory_placode1.70260237
39MP0003077_abnormal_cell_cycle1.68506533
40MP0003195_calcinosis1.63217271
41MP0002234_abnormal_pharynx_morphology1.58731700
42MP0008058_abnormal_DNA_repair1.56504611
43MP0000427_abnormal_hair_cycle1.54356107
44MP0005389_reproductive_system_phenotype1.54150514
45MP0008057_abnormal_DNA_replication1.52961021
46MP0002118_abnormal_lipid_homeostasis1.51732869
47MP0009697_abnormal_copulation1.50567498
48MP0003011_delayed_dark_adaptation1.49811362
49MP0003718_maternal_effect1.47548515
50MP0003191_abnormal_cellular_cholesterol1.46078719
51MP0005670_abnormal_white_adipose1.41213453
52MP0002160_abnormal_reproductive_system1.40000997
53MP0009643_abnormal_urine_homeostasis1.39395388
54MP0000598_abnormal_liver_morphology1.37478221
55MP0001529_abnormal_vocalization1.35175366
56MP0005645_abnormal_hypothalamus_physiol1.34046285
57MP0005319_abnormal_enzyme/_coenzyme1.33138654
58MP0005584_abnormal_enzyme/coenzyme_acti1.32681884
59MP0001968_abnormal_touch/_nociception1.31517796
60MP0002638_abnormal_pupillary_reflex1.28234627
61MP0005499_abnormal_olfactory_system1.26756308
62MP0005394_taste/olfaction_phenotype1.26756308
63MP0004043_abnormal_pH_regulation1.25883031
64MP0001919_abnormal_reproductive_system1.25167105
65MP0002138_abnormal_hepatobiliary_system1.22591531
66MP0005451_abnormal_body_composition1.21792079
67MP0002736_abnormal_nociception_after1.21267193
68MP0002938_white_spotting1.18690756
69MP0002163_abnormal_gland_morphology1.18595271
70MP0008260_abnormal_autophagy1.17565514
71MP0000569_abnormal_digit_pigmentation1.17400976
72MP0008775_abnormal_heart_ventricle1.16440036
73MP0002396_abnormal_hematopoietic_system1.16326784
74MP0008995_early_reproductive_senescence1.16102673
75MP0005084_abnormal_gallbladder_morpholo1.14972488
76MP0006035_abnormal_mitochondrial_morpho1.11558746
77MP0009046_muscle_twitch1.08610561
78MP0002751_abnormal_autonomic_nervous1.06612276
79MP0005058_abnormal_lysosome_morphology1.06313940
80MP0009765_abnormal_xenobiotic_induced1.06051293
81MP0002653_abnormal_ependyma_morphology1.04821655
82MP0004019_abnormal_vitamin_homeostasis1.04535471
83MP0004142_abnormal_muscle_tone1.03526981
84MP0005671_abnormal_response_to1.02341596
85MP0000383_abnormal_hair_follicle1.01758096
86MP0001730_embryonic_growth_arrest1.00732771
87MP0005636_abnormal_mineral_homeostasis1.00707996
88MP0006276_abnormal_autonomic_nervous1.00260642
89MP0000647_abnormal_sebaceous_gland0.99653007
90MP0000566_synostosis0.99540065
91MP0003880_abnormal_central_pattern0.96871447
92MP0002095_abnormal_skin_pigmentation0.96664098
93MP0004133_heterotaxia0.95163423
94MP0003698_abnormal_male_reproductive0.94389538
95MP0004215_abnormal_myocardial_fiber0.94162266
96MP0005379_endocrine/exocrine_gland_phen0.92594949
97MP0009763_increased_sensitivity_to0.91918559
98MP0005647_abnormal_sex_gland0.91906246
99MP0002132_abnormal_respiratory_system0.91748038
100MP0003121_genomic_imprinting0.90928433
101MP0005408_hypopigmentation0.90289253
102MP0008932_abnormal_embryonic_tissue0.90052525
103MP0001873_stomach_inflammation0.87242020
104MP0005266_abnormal_metabolism0.86540439
105MP0005195_abnormal_posterior_eye0.85139710
106MP0003705_abnormal_hypodermis_morpholog0.82755026
107MP0005391_vision/eye_phenotype0.82697503
108MP0000490_abnormal_crypts_of0.81907397
109MP0005075_abnormal_melanosome_morpholog0.81822647
110MP0003890_abnormal_embryonic-extraembry0.81528085
111MP0009745_abnormal_behavioral_response0.81491743
112MP0000465_gastrointestinal_hemorrhage0.80575771
113MP0008469_abnormal_protein_level0.79891451
114MP0006054_spinal_hemorrhage0.79746384
115MP0003786_premature_aging0.79426269
116MP0003136_yellow_coat_color0.78987669
117MP0005376_homeostasis/metabolism_phenot0.78596179
118MP0004145_abnormal_muscle_electrophysio0.78381569
119MP0001905_abnormal_dopamine_level0.77819872
120MP0000631_abnormal_neuroendocrine_gland0.77667029
121MP0000358_abnormal_cell_content/0.75696584
122MP0001661_extended_life_span0.74623261
123MP0000350_abnormal_cell_proliferation0.73274661
124MP0005410_abnormal_fertilization0.71130900
125MP0001324_abnormal_eye_pigmentation0.70747441
126MP0001853_heart_inflammation0.70688553
127MP0002019_abnormal_tumor_incidence0.70586359
128MP0001915_intracranial_hemorrhage0.70277690
129MP0002006_tumorigenesis0.70227338
130MP0002272_abnormal_nervous_system0.70164353
131MP0002557_abnormal_social/conspecific_i0.70085511
132MP0009333_abnormal_splenocyte_physiolog0.70082807
133MP0003878_abnormal_ear_physiology0.69743059
134MP0005377_hearing/vestibular/ear_phenot0.69743059
135MP0002009_preneoplasia0.69298479
136MP0009672_abnormal_birth_weight0.69255492
137MP0005646_abnormal_pituitary_gland0.68598680
138MP0001756_abnormal_urination0.67902628
139MP0002928_abnormal_bile_duct0.65796036
140MP0004924_abnormal_behavior0.65275145
141MP0005386_behavior/neurological_phenoty0.65275145
142MP0001929_abnormal_gametogenesis0.64954452
143MP0009642_abnormal_blood_homeostasis0.64191666
144MP0000313_abnormal_cell_death0.63544883
145MP0003690_abnormal_glial_cell0.63056195
146MP0002078_abnormal_glucose_homeostasis0.62513910
147MP0003699_abnormal_female_reproductive0.62078919
148MP0002080_prenatal_lethality0.61739767
149MP0000689_abnormal_spleen_morphology0.60459425
150MP0009764_decreased_sensitivity_to0.60110251
151MP0001697_abnormal_embryo_size0.57017163
152MP0010307_abnormal_tumor_latency0.56588170
153MP0008007_abnormal_cellular_replicative0.56569822
154MP0004264_abnormal_extraembryonic_tissu0.55982331
155MP0001293_anophthalmia0.55215635
156MP0005395_other_phenotype0.54842647
157MP0000653_abnormal_sex_gland0.54449759
158MP0003172_abnormal_lysosome_physiology0.54008506
159MP0005380_embryogenesis_phenotype0.52887875
160MP0001672_abnormal_embryogenesis/_devel0.52887875
161MP0001145_abnormal_male_reproductive0.51772343
162MP0002210_abnormal_sex_determination0.50230308
163MP0002876_abnormal_thyroid_physiology0.49430363
164MP0005334_abnormal_fat_pad0.49205083
165MP0002722_abnormal_immune_system0.48981977
166MP0001119_abnormal_female_reproductive0.47398900
167MP0005397_hematopoietic_system_phenotyp0.47247169

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.28326557
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.26453829
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.69896503
4Hypobetalipoproteinemia (HP:0003563)4.68819522
5Hypoglycemic coma (HP:0001325)4.46892385
6Hyperlipoproteinemia (HP:0010980)4.32560007
7Deep venous thrombosis (HP:0002625)4.16741937
8Abnormality of the heme biosynthetic pathway (HP:0010472)4.16549226
9Hyperglycinemia (HP:0002154)4.11543121
10Pancreatic cysts (HP:0001737)3.88385147
11Prolonged partial thromboplastin time (HP:0003645)3.79006655
12Hyperammonemia (HP:0001987)3.73896599
13Abnormality of pyrimidine metabolism (HP:0004353)3.71102741
14Poikilocytosis (HP:0004447)3.70685357
15Acanthocytosis (HP:0001927)3.70525453
16Fat malabsorption (HP:0002630)3.65310141
17Hyperbilirubinemia (HP:0002904)3.62389551
18Hypoglycemic seizures (HP:0002173)3.54725128
19Xanthomatosis (HP:0000991)3.52555113
20Abnormality of sulfur amino acid metabolism (HP:0004339)3.51171575
21Abnormality of glycine metabolism (HP:0010895)3.48346972
22Abnormality of serine family amino acid metabolism (HP:0010894)3.48346972
23Abnormality of methionine metabolism (HP:0010901)3.43417412
24Steatorrhea (HP:0002570)3.40354015
25Hyperglycinuria (HP:0003108)3.38845971
26Type II lissencephaly (HP:0007260)3.29956246
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.24635939
28Pancreatic fibrosis (HP:0100732)3.18397727
29Molar tooth sign on MRI (HP:0002419)3.16764738
30Abnormality of midbrain morphology (HP:0002418)3.16764738
31Hypolipoproteinemia (HP:0010981)3.13771382
32Ketosis (HP:0001946)3.12725000
33Congenital stationary night blindness (HP:0007642)3.09972388
34Conjugated hyperbilirubinemia (HP:0002908)3.08078315
35Abnormality of aspartate family amino acid metabolism (HP:0010899)3.04923418
36True hermaphroditism (HP:0010459)2.99494200
37Abnormality of the common coagulation pathway (HP:0010990)2.97691463
38Abnormality of the intrinsic pathway (HP:0010989)2.88002472
39Medial flaring of the eyebrow (HP:0010747)2.87730937
40Abnormality of serum amino acid levels (HP:0003112)2.85834740
41Lipid accumulation in hepatocytes (HP:0006561)2.85086538
42Mitochondrial inheritance (HP:0001427)2.82066107
43Increased CSF lactate (HP:0002490)2.81798610
44Acute necrotizing encephalopathy (HP:0006965)2.81382566
45Renal Fanconi syndrome (HP:0001994)2.79235128
46Abnormality of nucleobase metabolism (HP:0010932)2.78847080
47Abnormality of fatty-acid metabolism (HP:0004359)2.76073991
48Delayed CNS myelination (HP:0002188)2.75992359
49Acute encephalopathy (HP:0006846)2.75788625
50Nephronophthisis (HP:0000090)2.75644562
51Generalized aminoaciduria (HP:0002909)2.74223761
52Hyperinsulinemic hypoglycemia (HP:0000825)2.71759219
53Complement deficiency (HP:0004431)2.67836377
54Abolished electroretinogram (ERG) (HP:0000550)2.67670439
55Increased hepatocellular lipid droplets (HP:0006565)2.66063389
56Abnormality of alanine metabolism (HP:0010916)2.65106535
57Hyperalaninemia (HP:0003348)2.65106535
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65106535
59Progressive macrocephaly (HP:0004481)2.58121985
60Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.56453087
61Metabolic acidosis (HP:0001942)2.56259567
62Symptomatic seizures (HP:0011145)2.56017442
63Birth length less than 3rd percentile (HP:0003561)2.53349143
64Aplasia/Hypoplasia of the uvula (HP:0010293)2.53335455
65Dicarboxylic aciduria (HP:0003215)2.52803403
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.52803403
67Meckel diverticulum (HP:0002245)2.50570842
68Abnormal mitochondria in muscle tissue (HP:0008316)2.48962379
69Hypochromic microcytic anemia (HP:0004840)2.47851163
70Renal cortical cysts (HP:0000803)2.47662074
71Abnormality of the ileum (HP:0001549)2.47230906
72Colon cancer (HP:0003003)2.46360533
73Progressive inability to walk (HP:0002505)2.44975342
74Abnormality of the labia minora (HP:0012880)2.43922338
75Poor head control (HP:0002421)2.43500976
76Lethargy (HP:0001254)2.43253952
77Spastic diplegia (HP:0001264)2.42948391
78Abnormality of the renal medulla (HP:0100957)2.41025142
79Lissencephaly (HP:0001339)2.37964859
80Methylmalonic acidemia (HP:0002912)2.37529833
81Microvesicular hepatic steatosis (HP:0001414)2.37168726
82Abnormality of glycolysis (HP:0004366)2.36261544
83Increased serum pyruvate (HP:0003542)2.36261544
84Abnormal drinking behavior (HP:0030082)2.36106956
85Polydipsia (HP:0001959)2.36106956
86Attenuation of retinal blood vessels (HP:0007843)2.35923041
87Abnormality of purine metabolism (HP:0004352)2.32719249
88Stomach cancer (HP:0012126)2.32473657
89Chromosomal breakage induced by crosslinking agents (HP:0003221)2.32079192
90Cerebral edema (HP:0002181)2.31495218
91Hepatocellular necrosis (HP:0001404)2.30374748
92Nausea (HP:0002018)2.30077400
93Brushfield spots (HP:0001088)2.29890224
94Opisthotonus (HP:0002179)2.28417112
95Pendular nystagmus (HP:0012043)2.27475700
96Retinal dysplasia (HP:0007973)2.27442421
97Abnormal gallbladder morphology (HP:0012437)2.27366696
98Optic disc pallor (HP:0000543)2.26166657
99Congenital primary aphakia (HP:0007707)2.24750804
100Abnormality of glutamine family amino acid metabolism (HP:0010902)2.24678482
101Hypoalphalipoproteinemia (HP:0003233)2.24328164
102Abnormality of chromosome stability (HP:0003220)2.24059288
103Methylmalonic aciduria (HP:0012120)2.22743726
104Reticulocytosis (HP:0001923)2.22521199
105Cholelithiasis (HP:0001081)2.21602826
106Nephrogenic diabetes insipidus (HP:0009806)2.21600222
107Gout (HP:0001997)2.19885284
108Proximal tubulopathy (HP:0000114)2.18332255
109Inability to walk (HP:0002540)2.17356512
110Gait imbalance (HP:0002141)2.17080360
111Epidermoid cyst (HP:0200040)2.16847893
112Hepatic necrosis (HP:0002605)2.15901065
113Megaloblastic anemia (HP:0001889)2.09267372
114Impulsivity (HP:0100710)2.08410175
115Pancreatitis (HP:0001733)2.07666386
116Joint hemorrhage (HP:0005261)2.07183720
117Sloping forehead (HP:0000340)2.06719937
118Abnormality of the preputium (HP:0100587)2.04585401
119Thyroiditis (HP:0100646)2.04574510
1203-Methylglutaconic aciduria (HP:0003535)2.04265571
121Acute hepatic failure (HP:0006554)2.04084190
122Vomiting (HP:0002013)2.04014499
123Ketoacidosis (HP:0001993)2.02149277
124Polyuria (HP:0000103)2.01987801
125Abnormality of iron homeostasis (HP:0011031)2.00145939
126Abnormality of the renal cortex (HP:0011035)1.98482410
127Lactic acidosis (HP:0003128)1.98435781
128Sclerocornea (HP:0000647)1.97715923
129Severe combined immunodeficiency (HP:0004430)1.96868550
130Chromsome breakage (HP:0040012)1.95613367
131Abnormality of transition element cation homeostasis (HP:0011030)1.95492217
132IgG deficiency (HP:0004315)1.93103704
133Increased serum ferritin (HP:0003281)1.93012028
134Tubular atrophy (HP:0000092)1.92667733
135Panhypogammaglobulinemia (HP:0003139)1.92257209
136Hepatocellular carcinoma (HP:0001402)1.91031772
137Spastic paraparesis (HP:0002313)1.90803899
138Clubbing of toes (HP:0100760)1.89657345
139Cystic liver disease (HP:0006706)1.89447298
140Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89334477
141Abnormality of B cell number (HP:0010975)1.88766178
142Bile duct proliferation (HP:0001408)1.88490953
143Abnormal biliary tract physiology (HP:0012439)1.88490953
144Carpal bone hypoplasia (HP:0001498)1.88443779
145Patellar aplasia (HP:0006443)1.88357709
146Reduced antithrombin III activity (HP:0001976)1.87522762
147Increased serum lactate (HP:0002151)1.87247929
148Chorioretinal atrophy (HP:0000533)1.86484368
149Congenital, generalized hypertrichosis (HP:0004540)1.86142822
150Enlarged kidneys (HP:0000105)1.85594681
151Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85389986
152Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85389986
153Oral leukoplakia (HP:0002745)1.85369695
154Hypoplastic pelvis (HP:0008839)1.84431213
155Cerebellar dysplasia (HP:0007033)1.84034211
156Abnormality of reticulocytes (HP:0004312)1.83899389
157Systemic lupus erythematosus (HP:0002725)1.83133599
158Elevated hepatic transaminases (HP:0002910)1.82837872
159Abnormal delayed hypersensitivity skin test (HP:0002963)1.82523135
160Hypoproteinemia (HP:0003075)1.81293135
161Aplasia/Hypoplasia of the tibia (HP:0005772)1.81221603
162Aplasia/Hypoplasia of the patella (HP:0006498)1.79598540
163Abnormality of the pancreatic islet cells (HP:0006476)1.79244115
164Abnormality of endocrine pancreas physiology (HP:0012093)1.79244115
165Abnormality of the renal collecting system (HP:0004742)1.78426567
166Global brain atrophy (HP:0002283)1.78192022
167Abnormality of renal resorption (HP:0011038)1.78127365
168Duplicated collecting system (HP:0000081)1.77022835
169Hypothermia (HP:0002045)1.76031830
170Irritability (HP:0000737)1.74876542
171Aplasia/hypoplasia of the uterus (HP:0008684)1.74036871
172Decreased central vision (HP:0007663)1.74033307
173Abnormal rod and cone electroretinograms (HP:0008323)1.73285549
174Abnormality of T cell physiology (HP:0011840)1.72815999
175Abnormality of complement system (HP:0005339)1.72535687
176Congenital hepatic fibrosis (HP:0002612)1.72388154
177Genital tract atresia (HP:0001827)1.72235197
178Azoospermia (HP:0000027)1.71345680
179Aplasia/Hypoplasia of the tongue (HP:0010295)1.70918140
180Small intestinal stenosis (HP:0012848)1.69505665
181Duodenal stenosis (HP:0100867)1.69505665
182Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.68606397
183Abnormal protein N-linked glycosylation (HP:0012347)1.68606397
184Abnormal protein glycosylation (HP:0012346)1.68606397
185Abnormal glycosylation (HP:0012345)1.68606397

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.73855917
2FRK3.66126194
3PLK43.29889020
4EIF2AK13.22902113
5STK103.17136424
6WEE12.88354322
7BUB12.84438776
8WNK32.74109355
9NUAK12.70410383
10CDC72.58051060
11ADRBK22.53485544
12TTK2.44795659
13NEK22.40572086
14MUSK2.26607310
15MST42.25505554
16MAP4K22.15275092
17PASK2.13773817
18NME22.09979505
19GRK11.93804177
20VRK11.93129686
21MAP3K41.89892005
22TXK1.86730858
23TRIM281.82607951
24EIF2AK31.74907770
25SRPK11.74603607
26MKNK21.70840130
27ERN11.68553392
28VRK21.64720179
29NEK11.64628475
30FLT31.61243271
31STK161.59515108
32WNK41.53925596
33DYRK31.49137065
34AURKB1.45696351
35FGFR41.45020936
36ATR1.43200287
37PLK11.39280437
38BRAF1.35382268
39STK41.34819678
40TAOK31.32635857
41SCYL21.31726999
42TYK21.25697234
43ERBB31.23731674
44MAPK131.23103630
45IRAK31.21789554
46STK31.20972245
47MAP2K71.20852562
48PINK11.20138998
49PIM11.17104969
50BRSK21.17038928
51MAP3K81.14137527
52BCR1.13965916
53INSRR1.10878749
54CASK1.07969148
55CDK71.05564427
56TIE11.03115577
57PRKD31.01274197
58OXSR11.00835807
59PLK20.98460429
60AURKA0.97440137
61PDK40.96460449
62PDK30.96460449
63CSNK1G30.96440828
64PIK3CA0.95332653
65MARK30.95059106
66ACVR1B0.94561542
67LATS10.93794533
68TESK20.93474753
69PIK3CG0.92703545
70CDK190.92284416
71STK390.88575427
72CSNK1G20.87101395
73CSNK1G10.86965720
74LRRK20.86378794
75MAPK110.86251921
76TSSK60.85910237
77CCNB10.85275591
78DYRK20.85203857
79PLK30.83129998
80ADRBK10.81066921
81TEC0.79576675
82MAP4K10.79521577
83CHEK20.79232158
84CDK40.77928818
85BMPR1B0.77015757
86CHEK10.76875396
87TGFBR10.75527907
88CSNK1A1L0.73326085
89EPHA20.71934448
90RPS6KB20.70602322
91ZAK0.69809077
92PIM20.69520846
93EPHA30.68122625
94ATM0.68030857
95DAPK20.67612144
96CDK80.64242167
97ABL20.63164144
98AKT30.63023134
99NME10.61989258
100TAF10.61220330
101RPS6KA40.61105325
102CDK120.61065972
103GRK70.61020829
104ERBB40.60227983
105PRKCI0.60180592
106PBK0.59678752
107TNIK0.58963846
108CAMKK20.58931575
109PAK30.57656218
110MAPKAPK50.57374051
111PRKCQ0.56520515
112PRKCG0.55973528
113TRIB30.55423644
114MKNK10.55332026
115PRKCE0.54922932
116STK38L0.51607134
117CSNK2A10.50884348
118CSNK1D0.50700933
119TLK10.48817572
120MOS0.48496315
121SIK10.46605734
122GRK60.45840644
123BRSK10.45730231
124JAK30.45263846
125MAPKAPK30.43981764
126KIT0.43637301
127JAK20.42849426
128ITK0.40603780
129MAP3K100.40502271
130CSNK2A20.39863392
131CSF1R0.39333101
132CDK10.39214231
133MET0.38956891
134BRD40.38437261
135LYN0.38141614
136ZAP700.37987261
137CDK20.37623080
138NLK0.36542106
139PKN10.35108526
140RPS6KA50.34691091
141EIF2AK20.33355377
142PDK20.33161488
143IKBKB0.33110524
144CDK60.33037136
145PAK10.32592672
146MAP2K20.31992880
147IKBKE0.31844123
148FER0.31332154
149CSNK1A10.31036960
150CAMK2A0.26846951
151SYK0.25450651

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.21474112
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.02622619
3Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.88784025
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.47714747
5Oxidative phosphorylation_Homo sapiens_hsa001902.19384743
6Folate biosynthesis_Homo sapiens_hsa007902.18867052
7Selenocompound metabolism_Homo sapiens_hsa004502.17330051
8Fatty acid degradation_Homo sapiens_hsa000712.13776448
9Vitamin B6 metabolism_Homo sapiens_hsa007502.06363006
10One carbon pool by folate_Homo sapiens_hsa006702.04425812
11Peroxisome_Homo sapiens_hsa041462.03996431
12Arginine biosynthesis_Homo sapiens_hsa002202.03951534
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.03410383
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01084614
15Phototransduction_Homo sapiens_hsa047441.92688603
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91321266
17Tryptophan metabolism_Homo sapiens_hsa003801.90060520
18DNA replication_Homo sapiens_hsa030301.89162930
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86561578
20Steroid biosynthesis_Homo sapiens_hsa001001.86362775
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.86196200
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.85858753
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.83241963
24Parkinsons disease_Homo sapiens_hsa050121.83152235
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.72430177
26Propanoate metabolism_Homo sapiens_hsa006401.69884619
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69145504
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56479096
29Fatty acid metabolism_Homo sapiens_hsa012121.54727332
30Biosynthesis of amino acids_Homo sapiens_hsa012301.52836986
31Primary immunodeficiency_Homo sapiens_hsa053401.52335797
32Complement and coagulation cascades_Homo sapiens_hsa046101.51716663
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.50346104
34Fatty acid elongation_Homo sapiens_hsa000621.47809071
35Sulfur relay system_Homo sapiens_hsa041221.44486893
36Homologous recombination_Homo sapiens_hsa034401.43076342
37Proteasome_Homo sapiens_hsa030501.42333813
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.40482359
39Butanoate metabolism_Homo sapiens_hsa006501.39904022
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39864367
41Mismatch repair_Homo sapiens_hsa034301.36976722
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.34974273
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.28171665
44Carbon metabolism_Homo sapiens_hsa012001.25689032
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25360459
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24467719
47beta-Alanine metabolism_Homo sapiens_hsa004101.22707900
48Fat digestion and absorption_Homo sapiens_hsa049751.21817831
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21385010
50Histidine metabolism_Homo sapiens_hsa003401.20735184
51Vitamin digestion and absorption_Homo sapiens_hsa049771.16487757
52Base excision repair_Homo sapiens_hsa034101.16367028
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.16225984
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15726860
55Pyrimidine metabolism_Homo sapiens_hsa002401.15562449
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14298025
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13171014
58Pentose phosphate pathway_Homo sapiens_hsa000301.12107690
59Protein export_Homo sapiens_hsa030601.11192900
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11145070
61Huntingtons disease_Homo sapiens_hsa050161.10849672
62Steroid hormone biosynthesis_Homo sapiens_hsa001401.09555045
63RNA polymerase_Homo sapiens_hsa030201.09415742
64Pyruvate metabolism_Homo sapiens_hsa006201.08938035
65Intestinal immune network for IgA production_Homo sapiens_hsa046721.08916493
66Chemical carcinogenesis_Homo sapiens_hsa052041.07103284
67Arginine and proline metabolism_Homo sapiens_hsa003301.06978593
68Non-homologous end-joining_Homo sapiens_hsa034501.06592772
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06513038
70PPAR signaling pathway_Homo sapiens_hsa033201.05714247
71Glutathione metabolism_Homo sapiens_hsa004801.03251095
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01788821
73Caffeine metabolism_Homo sapiens_hsa002321.01252314
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98220651
75Alzheimers disease_Homo sapiens_hsa050100.96546684
76Nucleotide excision repair_Homo sapiens_hsa034200.91631135
77ABC transporters_Homo sapiens_hsa020100.91600127
78Type I diabetes mellitus_Homo sapiens_hsa049400.91005173
79Ether lipid metabolism_Homo sapiens_hsa005650.90684456
80Retinol metabolism_Homo sapiens_hsa008300.90111240
81Graft-versus-host disease_Homo sapiens_hsa053320.87829746
82Sulfur metabolism_Homo sapiens_hsa009200.87655009
83Phenylalanine metabolism_Homo sapiens_hsa003600.87163228
84Tyrosine metabolism_Homo sapiens_hsa003500.87131613
85Staphylococcus aureus infection_Homo sapiens_hsa051500.86913654
86Olfactory transduction_Homo sapiens_hsa047400.84508459
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80934848
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79565197
89Cell cycle_Homo sapiens_hsa041100.79348113
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78718194
91Allograft rejection_Homo sapiens_hsa053300.78481741
92RNA transport_Homo sapiens_hsa030130.77597857
93Asthma_Homo sapiens_hsa053100.77297996
94Metabolic pathways_Homo sapiens_hsa011000.75303715
95Autoimmune thyroid disease_Homo sapiens_hsa053200.74430399
96Lysine degradation_Homo sapiens_hsa003100.69129156
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66934679
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66761867
99Spliceosome_Homo sapiens_hsa030400.64273972
100Arachidonic acid metabolism_Homo sapiens_hsa005900.62895152
101Antigen processing and presentation_Homo sapiens_hsa046120.62441847
102Fanconi anemia pathway_Homo sapiens_hsa034600.59228029
103Basal transcription factors_Homo sapiens_hsa030220.58918168
104Systemic lupus erythematosus_Homo sapiens_hsa053220.56418428
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55708228
106Starch and sucrose metabolism_Homo sapiens_hsa005000.54560177
107Fatty acid biosynthesis_Homo sapiens_hsa000610.53963958
108Ribosome_Homo sapiens_hsa030100.53769987
109Glycerolipid metabolism_Homo sapiens_hsa005610.50498713
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49221228
111Nicotine addiction_Homo sapiens_hsa050330.47183592
112Purine metabolism_Homo sapiens_hsa002300.47108356
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46934706
114Linoleic acid metabolism_Homo sapiens_hsa005910.46579408
115Collecting duct acid secretion_Homo sapiens_hsa049660.45261286
116Bile secretion_Homo sapiens_hsa049760.43926603
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42638459
118Fructose and mannose metabolism_Homo sapiens_hsa000510.41022845
119RNA degradation_Homo sapiens_hsa030180.40977341
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40274995
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36581694
122Rheumatoid arthritis_Homo sapiens_hsa053230.33253566
123Oocyte meiosis_Homo sapiens_hsa041140.31692207
124p53 signaling pathway_Homo sapiens_hsa041150.31464413
125Regulation of autophagy_Homo sapiens_hsa041400.30842588
126N-Glycan biosynthesis_Homo sapiens_hsa005100.30203407
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29348699
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29201488
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28096960
130Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26590488
131Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25222056

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