TBCD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.78417476
2COPI coating of Golgi vesicle (GO:0048205)6.78417476
3regulation of translational fidelity (GO:0006450)6.00657863
4regulation of translational termination (GO:0006449)4.88801509
5folic acid-containing compound biosynthetic process (GO:0009396)4.78409605
6planar cell polarity pathway involved in neural tube closure (GO:0090179)4.53659048
7DNA unwinding involved in DNA replication (GO:0006268)4.52600037
8apoptotic process involved in morphogenesis (GO:0060561)4.45977175
9IMP biosynthetic process (GO:0006188)4.35205911
10retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.27508587
11protein complex localization (GO:0031503)3.74626893
12regulation of mammary gland epithelial cell proliferation (GO:0033599)3.68678446
13regulation of translational elongation (GO:0006448)3.68194338
14IMP metabolic process (GO:0046040)3.65428029
15activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.64636643
16positive regulation of nuclease activity (GO:0032075)3.62715668
17cytoskeletal anchoring at plasma membrane (GO:0007016)3.57271033
18protein-DNA complex disassembly (GO:0032986)3.57235492
19nucleosome disassembly (GO:0006337)3.57235492
20nuclear pore complex assembly (GO:0051292)3.56316257
21regulation of histone H3-K9 methylation (GO:0051570)3.51367520
22intracellular estrogen receptor signaling pathway (GO:0030520)3.48355374
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.47221604
24protein localization to kinetochore (GO:0034501)3.46582126
25peptidyl-lysine dimethylation (GO:0018027)3.46131442
26convergent extension (GO:0060026)3.46040792
27semaphorin-plexin signaling pathway (GO:0071526)3.45875522
28regulation of nuclease activity (GO:0032069)3.43474334
29nuclear pore organization (GO:0006999)3.36881553
303-UTR-mediated mRNA stabilization (GO:0070935)3.32993588
31* adherens junction assembly (GO:0034333)3.30654121
32DNA replication-dependent nucleosome organization (GO:0034723)3.29655713
33DNA replication-dependent nucleosome assembly (GO:0006335)3.29655713
34focal adhesion assembly (GO:0048041)3.27173834
35cell-substrate adherens junction assembly (GO:0007045)3.27173834
36pentose-phosphate shunt (GO:0006098)3.25757393
37DNA duplex unwinding (GO:0032508)3.25143296
38dosage compensation (GO:0007549)3.25130388
39mRNA stabilization (GO:0048255)3.24307229
40RNA stabilization (GO:0043489)3.24307229
41cellular protein complex localization (GO:0034629)3.23804397
42negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.23366668
43L-alpha-amino acid transmembrane transport (GO:1902475)3.22983609
44DNA geometric change (GO:0032392)3.22883231
45peptidyl-arginine omega-N-methylation (GO:0035247)3.22528260
46spliceosomal tri-snRNP complex assembly (GO:0000244)3.22412756
47antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16675732
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16675732
49endoplasmic reticulum unfolded protein response (GO:0030968)3.15406808
50chromatin assembly (GO:0031497)3.13174971
51DNA replication initiation (GO:0006270)3.13036017
52negative regulation of cell size (GO:0045792)3.12873264
53vesicle coating (GO:0006901)3.09900704
54positive regulation of histone deacetylation (GO:0031065)3.09604158
55cellular response to epidermal growth factor stimulus (GO:0071364)3.06895847
56sister chromatid segregation (GO:0000819)3.06400078
57neural tube development (GO:0021915)3.02678607
58apoptotic process involved in development (GO:1902742)3.02248855
59cellular response to unfolded protein (GO:0034620)3.01039864
60protein retention in ER lumen (GO:0006621)3.00222923
61heterochromatin organization (GO:0070828)3.00166569
62regulation of nucleobase-containing compound transport (GO:0032239)2.99610645
63determination of adult lifespan (GO:0008340)2.98930649
64ER-nucleus signaling pathway (GO:0006984)2.95935679
65histone arginine methylation (GO:0034969)2.95801934
66negative regulation of erythrocyte differentiation (GO:0045647)2.95259671
67NADPH regeneration (GO:0006740)2.94813092
68protein autoprocessing (GO:0016540)2.88577117
69macroautophagy (GO:0016236)2.87417654
70regulation of protein heterodimerization activity (GO:0043497)2.87245154
71activation of Rac GTPase activity (GO:0032863)2.86897154
72regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.85936504
73regulation of RNA export from nucleus (GO:0046831)2.85513529
74mannose metabolic process (GO:0006013)2.84939893
75mitotic chromosome condensation (GO:0007076)2.84144183
76regulation of sister chromatid cohesion (GO:0007063)2.84085229
77cellular response to topologically incorrect protein (GO:0035967)2.83169732
78glucocorticoid receptor signaling pathway (GO:0042921)2.83095423
79antigen processing and presentation of endogenous antigen (GO:0019883)2.81825514
80L-serine metabolic process (GO:0006563)2.81485762
81paraxial mesoderm development (GO:0048339)2.80866149
82epithelial cell differentiation involved in prostate gland development (GO:0060742)2.80106901
83stress granule assembly (GO:0034063)2.79879507
84embryonic process involved in female pregnancy (GO:0060136)2.79339255
85nuclear envelope disassembly (GO:0051081)2.78465072
86membrane disassembly (GO:0030397)2.78465072
87histone H4 deacetylation (GO:0070933)2.77597066
88Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.76522911
89mitotic nuclear envelope disassembly (GO:0007077)2.76323722
90basement membrane organization (GO:0071711)2.74373912
91DNA strand elongation (GO:0022616)2.74077067
92snRNA metabolic process (GO:0016073)2.73335233
93DNA topological change (GO:0006265)2.71887981
94pteridine-containing compound biosynthetic process (GO:0042559)2.71440276
95cell migration in hindbrain (GO:0021535)2.70610601
96protein export from nucleus (GO:0006611)2.70151911
97regulation of establishment of planar polarity (GO:0090175)2.69507801
98spindle assembly involved in mitosis (GO:0090307)2.66636790
99tetrahydrofolate metabolic process (GO:0046653)2.66152539
100chromosome condensation (GO:0030261)2.65953948
101protein localization to endosome (GO:0036010)2.65937596
102stress fiber assembly (GO:0043149)2.65796247
103nerve growth factor signaling pathway (GO:0038180)2.65780748
104negative regulation of myotube differentiation (GO:0010832)2.65316075
105pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.65291727
106UMP metabolic process (GO:0046049)2.65291727
107pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.65291727
108UMP biosynthetic process (GO:0006222)2.65291727
109peptidyl-arginine methylation (GO:0018216)2.65135691
110peptidyl-arginine N-methylation (GO:0035246)2.65135691
111regulation of early endosome to late endosome transport (GO:2000641)2.64913127
112regulation of mitotic spindle organization (GO:0060236)2.64776187
113developmental programmed cell death (GO:0010623)2.63823866
114negative regulation of mRNA metabolic process (GO:1903312)2.63248416
115negative regulation of histone methylation (GO:0031061)2.62666431
116mitotic sister chromatid segregation (GO:0000070)2.62426078
117mitotic G1 DNA damage checkpoint (GO:0031571)2.62202291
118regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.61941382
119pre-miRNA processing (GO:0031054)2.61818549
120myelin maintenance (GO:0043217)2.61787718
121regulation of ARF GTPase activity (GO:0032312)2.61463786
122mitotic sister chromatid cohesion (GO:0007064)2.61116874
123cortical actin cytoskeleton organization (GO:0030866)2.60874012
124cell adhesion mediated by integrin (GO:0033627)2.59285992
125regulation of NFAT protein import into nucleus (GO:0051532)2.58624573
126positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.58269457
127maternal placenta development (GO:0001893)2.58002986
128pore complex assembly (GO:0046931)2.56870605
129regulation of chromatin binding (GO:0035561)2.56609597
130positive regulation of SMAD protein import into nucleus (GO:0060391)2.56428464
131regulation of histone H3-K27 methylation (GO:0061085)2.56373065
132regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.56287038
133glucose catabolic process (GO:0006007)2.56116624
134proline metabolic process (GO:0006560)2.54138483
135cell-substrate junction assembly (GO:0007044)2.53555832
136cell-cell junction maintenance (GO:0045217)2.53506803
137mitotic G1/S transition checkpoint (GO:0044819)2.52286308
138regulation of protein export from nucleus (GO:0046825)2.51865596
139lipopolysaccharide biosynthetic process (GO:0009103)2.51487639
140negative regulation of mRNA processing (GO:0050686)2.51213624
141proline biosynthetic process (GO:0006561)2.49696665
142regulation of glucose import in response to insulin stimulus (GO:2001273)2.49307380
143modulation by virus of host morphology or physiology (GO:0019048)2.48645535
144epithelial cell-cell adhesion (GO:0090136)2.47696395
145microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.47409466
146DNA conformation change (GO:0071103)2.46945201
147regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46474122
148mitotic spindle organization (GO:0007052)2.46411789
149establishment of monopolar cell polarity (GO:0061162)2.45678266
150establishment or maintenance of monopolar cell polarity (GO:0061339)2.45678266
151corticosteroid receptor signaling pathway (GO:0031958)2.45278899
152response to endoplasmic reticulum stress (GO:0034976)2.43668337
153barbed-end actin filament capping (GO:0051016)2.43390523
154positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.42880961
155response to epidermal growth factor (GO:0070849)2.42849598
156DNA strand elongation involved in DNA replication (GO:0006271)2.42343674
157translesion synthesis (GO:0019985)2.42011263
158protein localization to chromosome, centromeric region (GO:0071459)2.41586915
159positive regulation of cell cycle G2/M phase transition (GO:1902751)2.41521635
160positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.41521635
161chromatin silencing (GO:0006342)2.41208503
162positive regulation of gene expression, epigenetic (GO:0045815)2.40565823
163ncRNA 3-end processing (GO:0043628)2.38824859
164response to nerve growth factor (GO:1990089)2.38502741
165cellular response to nerve growth factor stimulus (GO:1990090)2.38502741
166receptor catabolic process (GO:0032801)2.38142804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.08824042
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.98151726
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.02958005
4FOXM1_23109430_ChIP-Seq_U2OS_Human4.01399486
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06158124
6MYC_22102868_ChIP-Seq_BL_Human2.90497198
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.50304900
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49745207
9VDR_21846776_ChIP-Seq_THP-1_Human2.25333186
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24823898
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17428327
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88649434
13ESR1_15608294_ChIP-ChIP_MCF-7_Human1.85752844
14AR_21909140_ChIP-Seq_LNCAP_Human1.85151711
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83558813
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79147660
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75295216
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74312389
19KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73736597
20KDM2B_26808549_Chip-Seq_DND41_Human1.71448064
21CLOCK_20551151_ChIP-Seq_293T_Human1.63741091
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.63668785
23STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62330237
24CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.61247516
25* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59406668
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.58223453
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58223215
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.55333073
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55096481
30P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54755825
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54346799
32P68_20966046_ChIP-Seq_HELA_Human1.52628453
33TET1_21451524_ChIP-Seq_MESCs_Mouse1.50647985
34SMC4_20622854_ChIP-Seq_HELA_Human1.49547044
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49098050
36TCF7_22412390_ChIP-Seq_EML_Mouse1.48976491
37* E2F1_21310950_ChIP-Seq_MCF-7_Human1.46794583
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44689221
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44090067
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43650979
41SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.41725092
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41678388
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.39650438
44GATA1_22025678_ChIP-Seq_K562_Human1.38491332
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36833626
46TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.35697274
47* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35327602
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34508827
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34490820
50LXR_22292898_ChIP-Seq_THP-1_Human1.34481894
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33498479
52ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29679816
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29029396
54MYC_18555785_ChIP-Seq_MESCs_Mouse1.28804108
55* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28558194
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28025261
57UTX_26944678_Chip-Seq_JUKART_Human1.27539598
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.27135413
59DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24332258
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.23506651
61TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23136320
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.22715434
63ATF3_27146783_Chip-Seq_COLON_Human1.22365826
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22249081
65* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22233337
66RACK7_27058665_Chip-Seq_MCF-7_Human1.21328707
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20822408
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.20541693
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20127608
70TFEB_21752829_ChIP-Seq_HELA_Human1.19785189
71* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19213191
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17929884
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17637608
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17516766
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17410771
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.17179583
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16658252
78RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16291216
79SPI1_23127762_ChIP-Seq_K562_Human1.16221531
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15551943
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15400927
82ZNF263_19887448_ChIP-Seq_K562_Human1.15318087
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15261971
84TP53_22127205_ChIP-Seq_IMR90_Human1.15074878
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.12255359
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12039869
87* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12037046
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11206469
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11146794
90ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10737460
91SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.10724467
92FOXO3_23340844_ChIP-Seq_DLD1_Human1.10173141
93MAF_26560356_Chip-Seq_TH2_Human1.09756012
94VDR_24763502_ChIP-Seq_THP-1_Human1.09726214
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.09424707
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06553574
97RUNX1_27514584_Chip-Seq_MCF-7_Human1.05856698
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05827881
99MAF_26560356_Chip-Seq_TH1_Human1.05794226
100KDM5A_27292631_Chip-Seq_BREAST_Human1.03540010
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.01445505
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00096792
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99184941
104KDM2B_26808549_Chip-Seq_K562_Human0.99130734
105CTCF_27219007_Chip-Seq_Bcells_Human0.98805651
106* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98565857
107CHD1_26751641_Chip-Seq_LNCaP_Human0.96751120
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95180778
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95111628
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95087706
111ELF1_20517297_ChIP-Seq_JURKAT_Human0.94748891
112THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93977030
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93449326
114MYC_19030024_ChIP-ChIP_MESCs_Mouse0.93211337
115XRN2_22483619_ChIP-Seq_HELA_Human0.93101031
116* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93005857
117NCOR1_26117541_ChIP-Seq_K562_Human0.92930666
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92784373
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.91765811
120MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91613786
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89629672
122CREB1_26743006_Chip-Seq_LNCaP_Human0.89473147
123* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87779198
124GATA1_19941826_ChIP-Seq_K562_Human0.87459104
125CIITA_25753668_ChIP-Seq_RAJI_Human0.86923683
126GATA6_25053715_ChIP-Seq_YYC3_Human0.86387482
127GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85782454
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85766706
129* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85581463
130RUNX1_22412390_ChIP-Seq_EML_Mouse0.84953913
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84884233
132CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83952354
133PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.83807946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps4.48206475
2MP0003705_abnormal_hypodermis_morpholog4.34131400
3MP0003300_gastrointestinal_ulcer3.91783919
4MP0002877_abnormal_melanocyte_morpholog3.74178691
5MP0008438_abnormal_cutaneous_collagen3.42505779
6MP0000569_abnormal_digit_pigmentation3.42373500
7MP0005076_abnormal_cell_differentiation2.89254755
8MP0000566_synostosis2.83279260
9MP0010307_abnormal_tumor_latency2.67320755
10MP0003566_abnormal_cell_adhesion2.59121703
11MP0005409_darkened_coat_color2.55940477
12MP0003283_abnormal_digestive_organ2.55203085
13MP0010030_abnormal_orbit_morphology2.41716984
14MP0008260_abnormal_autophagy2.34551296
15MP0010234_abnormal_vibrissa_follicle2.21675110
16MP0003111_abnormal_nucleus_morphology2.10744990
17MP0008057_abnormal_DNA_replication2.10661184
18MP0002249_abnormal_larynx_morphology1.99562834
19MP0006054_spinal_hemorrhage1.98952357
20MP0001348_abnormal_lacrimal_gland1.96885964
21MP0003806_abnormal_nucleotide_metabolis1.93335329
22MP0003172_abnormal_lysosome_physiology1.87823221
23MP0010094_abnormal_chromosome_stability1.80789084
24MP0004858_abnormal_nervous_system1.75445545
25MP0009672_abnormal_birth_weight1.74552297
26MP0000537_abnormal_urethra_morphology1.74152900
27MP0005451_abnormal_body_composition1.70795760
28MP0001730_embryonic_growth_arrest1.70535423
29MP0004957_abnormal_blastocyst_morpholog1.68368065
30MP0009840_abnormal_foam_cell1.63964016
31MP0002089_abnormal_postnatal_growth/wei1.60051614
32MP0001958_emphysema1.53810199
33MP0005666_abnormal_adipose_tissue1.49188880
34MP0003091_abnormal_cell_migration1.45858072
35MP0004185_abnormal_adipocyte_glucose1.45061521
36MP0001849_ear_inflammation1.43386479
37MP0000350_abnormal_cell_proliferation1.43120304
38MP0005023_abnormal_wound_healing1.42181198
39MP0000003_abnormal_adipose_tissue1.39555595
40MP0009780_abnormal_chondrocyte_physiolo1.34320119
41MP0003077_abnormal_cell_cycle1.33679401
42MP0004197_abnormal_fetal_growth/weight/1.33608822
43MP0002009_preneoplasia1.32240699
44MP0005058_abnormal_lysosome_morphology1.31722576
45MP0005275_abnormal_skin_tensile1.30826436
46MP0001299_abnormal_eye_distance/1.27393863
47MP0003385_abnormal_body_wall1.25527781
48MP0000678_abnormal_parathyroid_gland1.24363084
49MP0000751_myopathy1.23173422
50MP0000371_diluted_coat_color1.21651147
51MP0003183_abnormal_peptide_metabolism1.21091979
52MP0002084_abnormal_developmental_patter1.18209920
53MP0003453_abnormal_keratinocyte_physiol1.15661406
54MP0010630_abnormal_cardiac_muscle1.14696687
55MP0001346_abnormal_lacrimal_gland1.12821473
56MP0004381_abnormal_hair_follicle1.12299217
57MP0002796_impaired_skin_barrier1.09921250
58MP0003115_abnormal_respiratory_system1.09861050
59MP0003303_peritoneal_inflammation1.09757984
60MP0002822_catalepsy1.09028751
61MP0003890_abnormal_embryonic-extraembry1.08522120
62MP0004859_abnormal_synaptic_plasticity1.07856128
63MP0002080_prenatal_lethality1.07006699
64MP0005220_abnormal_exocrine_pancreas1.06451161
65MP0004233_abnormal_muscle_weight1.06405192
66MP0001697_abnormal_embryo_size1.05405372
67MP0002086_abnormal_extraembryonic_tissu1.05395631
68MP0001915_intracranial_hemorrhage1.03282546
69MP0000013_abnormal_adipose_tissue1.02151953
70MP0003861_abnormal_nervous_system1.02109263
71MP0003763_abnormal_thymus_physiology1.00077000
72MP0005623_abnormal_meninges_morphology0.98486236
73MP0005621_abnormal_cell_physiology0.98210884
74MP0003942_abnormal_urinary_system0.96998955
75MP0002653_abnormal_ependyma_morphology0.96875850
76MP0003123_paternal_imprinting0.95814473
77MP0000733_abnormal_muscle_development0.93795618
78MP0002166_altered_tumor_susceptibility0.93734602
79MP0005501_abnormal_skin_physiology0.92935033
80MP0004808_abnormal_hematopoietic_stem0.92870265
81MP0004272_abnormal_basement_membrane0.92828436
82MP0008961_abnormal_basal_metabolism0.92660899
83MP0002697_abnormal_eye_size0.92056220
84MP0002116_abnormal_craniofacial_bone0.91627792
85MP0000432_abnormal_head_morphology0.91356816
86MP0002735_abnormal_chemical_nociception0.90529394
87MP0005464_abnormal_platelet_physiology0.89894381
88MP0002085_abnormal_embryonic_tissue0.89803956
89MP0005083_abnormal_biliary_tract0.89197112
90MP0002092_abnormal_eye_morphology0.88320163
91MP0000313_abnormal_cell_death0.87873700
92MP0003191_abnormal_cellular_cholesterol0.87624396
93MP0009278_abnormal_bone_marrow0.87374699
94MP0003279_aneurysm0.87267867
95MP0002019_abnormal_tumor_incidence0.86775345
96MP0000579_abnormal_nail_morphology0.86551067
97MP0005375_adipose_tissue_phenotype0.85903348
98MP0005380_embryogenesis_phenotype0.85838694
99MP0001672_abnormal_embryogenesis/_devel0.85838694
100MP0000747_muscle_weakness0.84830858
101MP0006138_congestive_heart_failure0.84583082
102MP0010368_abnormal_lymphatic_system0.84544151
103MP0003329_amyloid_beta_deposits0.83729866
104MP0002925_abnormal_cardiovascular_devel0.83203587
105MP0001243_abnormal_dermal_layer0.83137109
106MP0004264_abnormal_extraembryonic_tissu0.82706409
107MP0000534_abnormal_ureter_morphology0.82586803
108MP0005360_urolithiasis0.81888979
109MP0002932_abnormal_joint_morphology0.81380268
110MP0003935_abnormal_craniofacial_develop0.80930821
111MP0000685_abnormal_immune_system0.80654942
112MP0003693_abnormal_embryo_hatching0.80599517
113MP0000759_abnormal_skeletal_muscle0.80305143
114MP0004811_abnormal_neuron_physiology0.80280602
115MP0003634_abnormal_glial_cell0.80113079
116MP0000467_abnormal_esophagus_morphology0.79824036
117MP0000604_amyloidosis0.79694820
118MP0000703_abnormal_thymus_morphology0.79537765
119MP0008770_decreased_survivor_rate0.79367709
120MP0000490_abnormal_crypts_of0.79160202
121MP0005384_cellular_phenotype0.78718498
122MP0003315_abnormal_perineum_morphology0.78705971
123MP0003045_fibrosis0.77215875
124MP0004087_abnormal_muscle_fiber0.76613321
125MP0000477_abnormal_intestine_morphology0.76410785
126MP0003984_embryonic_growth_retardation0.76154883
127MP0002114_abnormal_axial_skeleton0.75694626
128MP0005257_abnormal_intraocular_pressure0.75141383
129MP0002060_abnormal_skin_morphology0.75081303
130MP0002088_abnormal_embryonic_growth/wei0.74800939
131MP0000462_abnormal_digestive_system0.73953126
132MP0004947_skin_inflammation0.73634752
133MP0002909_abnormal_adrenal_gland0.72935559
134MP0002970_abnormal_white_adipose0.72683386
135MP0002896_abnormal_bone_mineralization0.72578077
136MP0002733_abnormal_thermal_nociception0.72507687
137MP0002751_abnormal_autonomic_nervous0.72496610
138MP0000858_altered_metastatic_potential0.72102683
139MP0002396_abnormal_hematopoietic_system0.71307496
140MP0009053_abnormal_anal_canal0.71240496
141MP0002111_abnormal_tail_morphology0.71072310
142MP0000358_abnormal_cell_content/0.70681198
143MP0002075_abnormal_coat/hair_pigmentati0.68113558
144MP0002269_muscular_atrophy0.68044819
145MP0008932_abnormal_embryonic_tissue0.67665756
146MP0003632_abnormal_nervous_system0.67425529
147MP0000428_abnormal_craniofacial_morphol0.64161914
148MP0000427_abnormal_hair_cycle0.63336252
149MP0009703_decreased_birth_body0.62777090

Predicted human phenotypes

RankGene SetZ-score
1Insidious onset (HP:0003587)3.48513608
2Termporal pattern (HP:0011008)3.48513608
3Broad face (HP:0000283)3.20008007
4Hand muscle atrophy (HP:0009130)3.14691005
5Abnormality of the fingertips (HP:0001211)3.13428842
6Obstructive sleep apnea (HP:0002870)3.08887682
7Cerebral aneurysm (HP:0004944)2.92185821
8Upper limb amyotrophy (HP:0009129)2.90340577
9Distal upper limb amyotrophy (HP:0007149)2.90340577
10Rectal prolapse (HP:0002035)2.78455139
11Long palpebral fissure (HP:0000637)2.76295332
12Disproportionate tall stature (HP:0001519)2.67196085
13Bowel diverticulosis (HP:0005222)2.56220263
14Hypercortisolism (HP:0001578)2.53776070
15Hyperacusis (HP:0010780)2.52655757
16Cortical dysplasia (HP:0002539)2.44966426
17Abnormality of the distal phalanx of the thumb (HP:0009617)2.44351757
18Centrally nucleated skeletal muscle fibers (HP:0003687)2.40786774
19Protrusio acetabuli (HP:0003179)2.39809198
20Premature rupture of membranes (HP:0001788)2.34411858
21Distal lower limb amyotrophy (HP:0008944)2.33130848
22Broad distal phalanx of finger (HP:0009836)2.32327473
23Insomnia (HP:0100785)2.30354356
24Trigonocephaly (HP:0000243)2.28351570
25Macroorchidism (HP:0000053)2.28021657
26Cutaneous melanoma (HP:0012056)2.27769906
27Ependymoma (HP:0002888)2.27753000
28Dysmetric saccades (HP:0000641)2.25526596
29Abnormality of the calcaneus (HP:0008364)2.24581083
30Biconcave vertebral bodies (HP:0004586)2.22319874
31Premature skin wrinkling (HP:0100678)2.21873334
32Abnormality of the astrocytes (HP:0100707)2.20625632
33Astrocytoma (HP:0009592)2.20625632
34Bronchomalacia (HP:0002780)2.20047412
35Abnormality of the anterior horn cell (HP:0006802)2.18823202
36Degeneration of anterior horn cells (HP:0002398)2.18823202
37Bladder diverticulum (HP:0000015)2.16811087
38Asymmetry of the thorax (HP:0001555)2.14997097
39Dilatation of the ascending aorta (HP:0005111)2.14688354
40Spinal muscular atrophy (HP:0007269)2.13352443
41Cervical subluxation (HP:0003308)2.11035610
42Increased connective tissue (HP:0009025)2.10093070
43Ulnar bowing (HP:0003031)2.09689918
44Flat acetabular roof (HP:0003180)2.09288194
45Increased mean platelet volume (HP:0011877)2.05831103
46Spastic diplegia (HP:0001264)2.05208494
47Patellar dislocation (HP:0002999)2.05139632
48Heterotopia (HP:0002282)2.04444151
49Long eyelashes (HP:0000527)2.03449821
50Ankle contracture (HP:0006466)2.02222252
51Thin ribs (HP:0000883)2.02124872
52Increased density of long bones (HP:0006392)2.01263574
53Subacute progressive viral hepatitis (HP:0006572)1.98557995
54Shallow orbits (HP:0000586)1.97616568
55Vertebral arch anomaly (HP:0008438)1.97277950
56Arnold-Chiari malformation (HP:0002308)1.96818762
57Thin bony cortex (HP:0002753)1.96689496
58Resting tremor (HP:0002322)1.95676393
59Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95501329
60Metaphyseal cupping (HP:0003021)1.94969697
61Global brain atrophy (HP:0002283)1.94819922
62Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.94375039
63Short 4th metacarpal (HP:0010044)1.94375039
64Turricephaly (HP:0000262)1.93671079
65Pointed chin (HP:0000307)1.93186067
66Overlapping toe (HP:0001845)1.92150571
67Aortic aneurysm (HP:0004942)1.91739445
68Precocious puberty (HP:0000826)1.91426363
69Long toe (HP:0010511)1.90840573
70Annular pancreas (HP:0001734)1.90442679
71Advanced eruption of teeth (HP:0006288)1.90248671
72Renal duplication (HP:0000075)1.90131640
73Elfin facies (HP:0004428)1.89630884
74Ankyloglossia (HP:0010296)1.89540735
75Lower limb amyotrophy (HP:0007210)1.89321831
76Achilles tendon contracture (HP:0001771)1.88379142
77Lymphangioma (HP:0100764)1.88002109
78Missing ribs (HP:0000921)1.87616037
79High anterior hairline (HP:0009890)1.87554775
80Dislocated radial head (HP:0003083)1.87143098
81Fragile skin (HP:0001030)1.85790171
82Abnormal platelet volume (HP:0011876)1.84648256
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83785448
84Abnormality of the pancreatic islet cells (HP:0006476)1.83593338
85Abnormality of endocrine pancreas physiology (HP:0012093)1.83593338
86Abnormality of oral frenula (HP:0000190)1.81717676
87Freckling (HP:0001480)1.81628891
88Mitral valve prolapse (HP:0001634)1.80901084
89Skull defect (HP:0001362)1.79802166
90Broad thumb (HP:0011304)1.79408871
91Abnormality of the thoracic spine (HP:0100711)1.78532802
92Abnormality of the radial head (HP:0003995)1.78448367
93Urinary urgency (HP:0000012)1.77380665
94Abnormality of the phalanges of the hallux (HP:0010057)1.77208317
95Deviation of the thumb (HP:0009603)1.77078807
96Urethral obstruction (HP:0000796)1.76307487
97Deep palmar crease (HP:0006191)1.75757855
98Volvulus (HP:0002580)1.75520345
99Broad metatarsal (HP:0001783)1.75284188
100Mitral regurgitation (HP:0001653)1.75246244
101Upper limb muscle weakness (HP:0003484)1.74327955
102Hammertoe (HP:0001765)1.73961976
103Renovascular hypertension (HP:0100817)1.73947635
104Orthostatic hypotension (HP:0001278)1.73365365
105Pancreatic islet-cell hyperplasia (HP:0004510)1.73172104
106Hyperinsulinemic hypoglycemia (HP:0000825)1.72792072
107Fibroma (HP:0010614)1.72334394
108Natal tooth (HP:0000695)1.71793564
109Buphthalmos (HP:0000557)1.71382877
110Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.71221261
111Vertebral hypoplasia (HP:0008417)1.71221261
112Fibrous tissue neoplasm (HP:0012316)1.71022061
113Enlarged penis (HP:0000040)1.70627094
114Sparse lateral eyebrow (HP:0005338)1.70001130
115Broad phalanges of the hand (HP:0009768)1.69871550
116Flared metaphyses (HP:0003015)1.69564068
117Proximal placement of thumb (HP:0009623)1.68845568
118Foot dorsiflexor weakness (HP:0009027)1.67851370
119Gastrointestinal carcinoma (HP:0002672)1.67379937
120Malignant gastrointestinal tract tumors (HP:0006749)1.67379937
121Colon cancer (HP:0003003)1.65764779
122Reticulocytosis (HP:0001923)1.65624778
123Aneurysm (HP:0002617)1.65538183
124Aplasia involving bones of the extremities (HP:0009825)1.65529505
125Aplasia involving bones of the upper limbs (HP:0009823)1.65529505
126Aplasia of the phalanges of the hand (HP:0009802)1.65529505
127Vertebral compression fractures (HP:0002953)1.65498612
128Abnormality of the lower motor neuron (HP:0002366)1.65159427
129Cholecystitis (HP:0001082)1.65127040
130Abnormal gallbladder physiology (HP:0012438)1.65127040
131Spina bifida occulta (HP:0003298)1.65115920
132Broad palm (HP:0001169)1.63565340
133Stridor (HP:0010307)1.63480448
134Anal stenosis (HP:0002025)1.63378204
135Back pain (HP:0003418)1.62101011
136Broad finger (HP:0001500)1.61995203
137Increased nuchal translucency (HP:0010880)1.61820593
138Midface retrusion (HP:0011800)1.61460872
139Bowel incontinence (HP:0002607)1.61451951
140Trismus (HP:0000211)1.61158418
141Blue sclerae (HP:0000592)1.60155327
142Atelectasis (HP:0100750)1.60146743
143Progressive muscle weakness (HP:0003323)1.60065362
144Wormian bones (HP:0002645)1.59881515
145Wrist flexion contracture (HP:0001239)1.59510609
146Genu recurvatum (HP:0002816)1.59364867
147Increased variability in muscle fiber diameter (HP:0003557)1.59339746
148Abnormality of the Achilles tendon (HP:0005109)1.59152364
149Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.58818804
150Pseudobulbar signs (HP:0002200)1.58779357
151Ulnar claw (HP:0001178)1.58702304
152Adenoma sebaceum (HP:0009720)1.57862994
153Angiofibromas (HP:0010615)1.57862994
154Hyperparathyroidism (HP:0000843)1.57738777
155Abnormality of the humeroradial joint (HP:0100744)1.56363906
156Abnormality of the gastric mucosa (HP:0004295)1.56342171
157Mucopolysacchariduria (HP:0008155)1.55916145
158Urinary glycosaminoglycan excretion (HP:0003541)1.55916145
159Hypopigmentation of the fundus (HP:0007894)1.55898413
160Overriding aorta (HP:0002623)1.55550903
161Distal lower limb muscle weakness (HP:0009053)1.55156834
162Cafe-au-lait spot (HP:0000957)1.55151852
163Vertebral clefting (HP:0008428)1.55123819
164Spinal rigidity (HP:0003306)1.54954402
165Selective tooth agenesis (HP:0001592)1.54497267
166Flat cornea (HP:0007720)1.54462755
167Cerebral inclusion bodies (HP:0100314)1.52278182
168Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.52028049
169Absent epiphyses (HP:0010577)1.52028049

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.34667878
2SCYL24.04852144
3EEF2K3.82031125
4TRIB33.55368479
5PKN22.74674268
6LMTK22.36181645
7CDK122.09630109
8CDC72.04743499
9MAP3K101.97950833
10PDGFRA1.95322839
11NEK11.83458987
12NTRK11.82754418
13PTK61.82597624
14TESK11.82520815
15PASK1.80292876
16PRPF4B1.79396910
17TESK21.75927199
18LIMK11.69907803
19TTN1.69406513
20NEK21.59077646
21DDR21.45535836
22PRKD31.42945901
23MAP3K21.37128869
24MARK21.35158955
25RPS6KB21.32627106
26RIPK11.32524426
27ALK1.30371564
28MAP3K131.27734487
29FLT31.27214362
30LRRK21.26176167
31EPHB11.23958313
32SIK11.20105669
33MTOR1.19293526
34FRK1.16466973
35TRPM71.16345743
36RET1.16176549
37PRKD21.10714087
38IRAK31.08991235
39MAPKAPK31.07640108
40NME21.07031544
41ICK1.06810752
42BMX1.05763544
43MATK1.01668697
44CAMK1D1.01274842
45MET1.01130009
46FGFR30.98486920
47CDK40.98443608
48FER0.97908250
49ERN10.94613542
50YES10.93275020
51KSR20.91452417
52MST1R0.91333011
53MAP3K80.90804853
54FGFR40.90118506
55TLK10.88915437
56TSSK60.88411967
57TYK20.88047699
58RPS6KL10.85082238
59RPS6KC10.85082238
60CDK60.84830917
61BRD40.84346681
62EPHA30.84037744
63RPS6KA40.83470204
64TTK0.77390945
65CCNB10.77191675
66PRKCH0.76988080
67CHEK20.76755735
68MAPK110.75745329
69PDGFRB0.75025091
70PTK20.73178657
71TAOK10.71693841
72JAK10.71621230
73CAMKK10.71299770
74MAP3K60.68805270
75DYRK1B0.68683807
76EPHA20.68305202
77SIK20.68214629
78MAP3K70.65682512
79PAK40.65485704
80TYRO30.64562207
81STK100.63810182
82KSR10.63673440
83PAK60.62837680
84RPS6KA20.62302143
85PAK20.61730028
86TNK20.61521451
87BRAF0.60900139
88MAP3K30.60883693
89PRKG20.60673939
90LATS20.59843319
91ARAF0.59224060
92MAP3K110.59063501
93CDK90.58258428
94RPS6KA60.57944811
95ACVR1B0.57451800
96TAOK20.57005917
97FGFR20.56669409
98CDC42BPA0.56575193
99MAP3K90.56328341
100MARK30.55642365
101ATR0.55406864
102FGFR10.55209935
103GSK3A0.53778119
104MAP4K10.53720907
105JAK20.52512824
106ERBB30.52294916
107CSK0.51907177
108CDK80.51230553
109DYRK20.50897858
110BUB10.50752907
111MAP2K10.50699054
112AURKA0.50212014
113MAP2K20.49829685
114JAK30.48512392
115ERBB20.46515802
116BCKDK0.46343017
117CHEK10.44641954
118CDK11A0.43190731
119UHMK10.43148701
120CAMK1G0.42726907
121CAMK40.42580838
122TGFBR10.42509344
123CDK70.41877216
124AKT20.41750302
125PBK0.41524018
126ATM0.41477088
127BRSK10.41367389
128CDK20.41331826
129MAP2K30.40703372
130ROCK20.40668810
131CDK150.40258952
132SRC0.40169202
133CDK10.40050635
134PDPK10.39629467
135HIPK20.39453395
136INSR0.39346668
137MELK0.38919966
138ILK0.37983227
139GRK60.36062463
140AURKB0.35853439
141KDR0.35287983
142MAP3K10.34775973
143RPS6KA10.34253001
144CDK180.34084452
145MAPK100.33623273

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006702.42071708
2Chronic myeloid leukemia_Homo sapiens_hsa052202.26743001
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.18411523
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17072259
5DNA replication_Homo sapiens_hsa030302.05389011
6Systemic lupus erythematosus_Homo sapiens_hsa053221.99542318
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.81979538
8Nitrogen metabolism_Homo sapiens_hsa009101.76668439
9Viral carcinogenesis_Homo sapiens_hsa052031.75039916
10mTOR signaling pathway_Homo sapiens_hsa041501.70028576
11Mismatch repair_Homo sapiens_hsa034301.55508103
12Thyroid cancer_Homo sapiens_hsa052161.52719801
13Pentose phosphate pathway_Homo sapiens_hsa000301.51758231
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.51188250
15Alcoholism_Homo sapiens_hsa050341.49601013
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46803668
17mRNA surveillance pathway_Homo sapiens_hsa030151.46429130
18Other glycan degradation_Homo sapiens_hsa005111.46386382
19Small cell lung cancer_Homo sapiens_hsa052221.44112733
20Endometrial cancer_Homo sapiens_hsa052131.43345814
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.42370454
22Selenocompound metabolism_Homo sapiens_hsa004501.41852762
23Bladder cancer_Homo sapiens_hsa052191.38057067
24Pancreatic cancer_Homo sapiens_hsa052121.37862196
25Glioma_Homo sapiens_hsa052141.36028075
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34563584
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.32239198
28Prion diseases_Homo sapiens_hsa050201.31958010
29Basal cell carcinoma_Homo sapiens_hsa052171.26623282
30MicroRNAs in cancer_Homo sapiens_hsa052061.25761115
31Non-small cell lung cancer_Homo sapiens_hsa052231.23786750
32Cell cycle_Homo sapiens_hsa041101.23076932
33Type II diabetes mellitus_Homo sapiens_hsa049301.21330028
34Colorectal cancer_Homo sapiens_hsa052101.21300307
35Proteoglycans in cancer_Homo sapiens_hsa052051.20881586
36Fructose and mannose metabolism_Homo sapiens_hsa000511.20058271
37Apoptosis_Homo sapiens_hsa042101.16216901
38Focal adhesion_Homo sapiens_hsa045101.14198973
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10573659
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10127663
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09207281
42N-Glycan biosynthesis_Homo sapiens_hsa005101.08956440
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08184986
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.08016167
45Adherens junction_Homo sapiens_hsa045201.07803480
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06959693
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06224304
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.02499206
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02396421
50Choline metabolism in cancer_Homo sapiens_hsa052311.01825698
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00880553
52Spliceosome_Homo sapiens_hsa030401.00544547
53Melanogenesis_Homo sapiens_hsa049161.00007047
54Prolactin signaling pathway_Homo sapiens_hsa049170.98417561
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97934423
56Insulin signaling pathway_Homo sapiens_hsa049100.95228029
57p53 signaling pathway_Homo sapiens_hsa041150.94973893
58VEGF signaling pathway_Homo sapiens_hsa043700.94230321
59Insulin resistance_Homo sapiens_hsa049310.94062342
60Carbon metabolism_Homo sapiens_hsa012000.94059667
61Vitamin B6 metabolism_Homo sapiens_hsa007500.92619710
62Estrogen signaling pathway_Homo sapiens_hsa049150.91008633
63Antigen processing and presentation_Homo sapiens_hsa046120.90554809
64Base excision repair_Homo sapiens_hsa034100.90034599
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89163180
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.88577573
67HTLV-I infection_Homo sapiens_hsa051660.88352036
68Lysine degradation_Homo sapiens_hsa003100.87614821
69Hippo signaling pathway_Homo sapiens_hsa043900.87468598
70Wnt signaling pathway_Homo sapiens_hsa043100.86671642
71ABC transporters_Homo sapiens_hsa020100.85007221
72Toxoplasmosis_Homo sapiens_hsa051450.84141087
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83038009
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81091905
75Shigellosis_Homo sapiens_hsa051310.80801384
76Acute myeloid leukemia_Homo sapiens_hsa052210.80548780
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80249691
78Amoebiasis_Homo sapiens_hsa051460.80139158
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80106198
80Sulfur relay system_Homo sapiens_hsa041220.76919680
81Melanoma_Homo sapiens_hsa052180.75473571
82Prostate cancer_Homo sapiens_hsa052150.75136390
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74920608
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74579881
85Gap junction_Homo sapiens_hsa045400.74506351
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73472111
87Long-term potentiation_Homo sapiens_hsa047200.72825005
88AMPK signaling pathway_Homo sapiens_hsa041520.71917902
89B cell receptor signaling pathway_Homo sapiens_hsa046620.71590848
90Lysosome_Homo sapiens_hsa041420.71294796
91Biosynthesis of amino acids_Homo sapiens_hsa012300.70849145
92GnRH signaling pathway_Homo sapiens_hsa049120.70209740
93ECM-receptor interaction_Homo sapiens_hsa045120.70083755
94RNA transport_Homo sapiens_hsa030130.68927608
95Endocytosis_Homo sapiens_hsa041440.68674198
96Hepatitis B_Homo sapiens_hsa051610.67850105
97Axon guidance_Homo sapiens_hsa043600.67779812
98Platelet activation_Homo sapiens_hsa046110.67335818
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66539312
100Galactose metabolism_Homo sapiens_hsa000520.66111354
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.65923647
102Inositol phosphate metabolism_Homo sapiens_hsa005620.65862830
103Glucagon signaling pathway_Homo sapiens_hsa049220.64259117
104Hedgehog signaling pathway_Homo sapiens_hsa043400.63932278
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63082281
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62926916
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.61682020
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61043392
109Legionellosis_Homo sapiens_hsa051340.60983114
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60937513
111Oocyte meiosis_Homo sapiens_hsa041140.60242434
112ErbB signaling pathway_Homo sapiens_hsa040120.59094325
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.58491274
114Arginine biosynthesis_Homo sapiens_hsa002200.57558927
115Hepatitis C_Homo sapiens_hsa051600.56787878
116Pathways in cancer_Homo sapiens_hsa052000.53548578
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52839197
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52556080
119Leishmaniasis_Homo sapiens_hsa051400.51551657
120HIF-1 signaling pathway_Homo sapiens_hsa040660.51303392
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49582331
122Notch signaling pathway_Homo sapiens_hsa043300.48790831
123Rap1 signaling pathway_Homo sapiens_hsa040150.48723443
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48446744
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48098697
126Renal cell carcinoma_Homo sapiens_hsa052110.48041788
127Tight junction_Homo sapiens_hsa045300.47354500
128Viral myocarditis_Homo sapiens_hsa054160.47352631
129Vibrio cholerae infection_Homo sapiens_hsa051100.47239449

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