TBCEL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.67242694
2L-phenylalanine catabolic process (GO:0006559)6.67242694
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.28211583
4L-phenylalanine metabolic process (GO:0006558)6.28211583
5aromatic amino acid family catabolic process (GO:0009074)5.91364152
6alpha-linolenic acid metabolic process (GO:0036109)5.29195914
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.28513728
8tryptophan catabolic process (GO:0006569)5.18094532
9indole-containing compound catabolic process (GO:0042436)5.18094532
10indolalkylamine catabolic process (GO:0046218)5.18094532
11cysteine metabolic process (GO:0006534)5.16919888
12glyoxylate metabolic process (GO:0046487)5.06554775
13bile acid biosynthetic process (GO:0006699)5.04898937
14kynurenine metabolic process (GO:0070189)5.01430138
15tryptophan metabolic process (GO:0006568)4.81240562
16urea cycle (GO:0000050)4.76094249
17urea metabolic process (GO:0019627)4.76094249
18hemoglobin metabolic process (GO:0020027)4.70054498
19protein carboxylation (GO:0018214)4.68464274
20peptidyl-glutamic acid carboxylation (GO:0017187)4.68464274
21negative regulation of fibrinolysis (GO:0051918)4.66751577
22sulfur amino acid catabolic process (GO:0000098)4.61265109
23high-density lipoprotein particle remodeling (GO:0034375)4.57152502
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.45885467
25regulation of fibrinolysis (GO:0051917)4.41720884
26complement activation, alternative pathway (GO:0006957)4.41261547
27regulation of protein activation cascade (GO:2000257)4.37557545
28nitrogen cycle metabolic process (GO:0071941)4.37162138
29glutamate metabolic process (GO:0006536)4.33487409
30bile acid metabolic process (GO:0008206)4.32402361
31lysine catabolic process (GO:0006554)4.25550685
32lysine metabolic process (GO:0006553)4.25550685
33serine family amino acid catabolic process (GO:0009071)4.24647513
34homocysteine metabolic process (GO:0050667)4.16302839
35reverse cholesterol transport (GO:0043691)4.13700558
36negative regulation of cholesterol transport (GO:0032375)4.13322806
37negative regulation of sterol transport (GO:0032372)4.13322806
38aromatic amino acid family metabolic process (GO:0009072)4.11997253
39regulation of cholesterol esterification (GO:0010872)4.10999596
40regulation of complement activation (GO:0030449)4.10170162
41dicarboxylic acid biosynthetic process (GO:0043650)4.09633490
42tyrosine metabolic process (GO:0006570)4.06366353
43amino-acid betaine metabolic process (GO:0006577)4.05032558
44plasma lipoprotein particle assembly (GO:0034377)4.05028136
45coenzyme catabolic process (GO:0009109)4.00858159
46alpha-amino acid catabolic process (GO:1901606)3.97740151
47phospholipid efflux (GO:0033700)3.97384326
48regulation of triglyceride catabolic process (GO:0010896)3.96740024
49protein-lipid complex remodeling (GO:0034368)3.92204667
50macromolecular complex remodeling (GO:0034367)3.92204667
51plasma lipoprotein particle remodeling (GO:0034369)3.92204667
52cellular glucuronidation (GO:0052695)3.91026107
53drug catabolic process (GO:0042737)3.90783469
54acylglycerol homeostasis (GO:0055090)3.88984865
55triglyceride homeostasis (GO:0070328)3.88984865
56cholesterol efflux (GO:0033344)3.88410207
57phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.86872881
58very-low-density lipoprotein particle assembly (GO:0034379)3.84092055
59cellular modified amino acid catabolic process (GO:0042219)3.83489492
60response to methylmercury (GO:0051597)3.81644920
61hepatocyte apoptotic process (GO:0097284)3.81036878
62ethanol oxidation (GO:0006069)3.80311194
63plasma lipoprotein particle clearance (GO:0034381)3.80202689
64protein-lipid complex assembly (GO:0065005)3.76937216
65ovulation from ovarian follicle (GO:0001542)3.76543595
66regulation of cholesterol homeostasis (GO:2000188)3.74675918
67cellular ketone body metabolic process (GO:0046950)3.74500329
68cellular amino acid catabolic process (GO:0009063)3.69918641
69bile acid and bile salt transport (GO:0015721)3.68571232
70monoubiquitinated protein deubiquitination (GO:0035520)3.58785342
71amine catabolic process (GO:0009310)3.58736677
72cellular biogenic amine catabolic process (GO:0042402)3.58736677
73indolalkylamine metabolic process (GO:0006586)3.56189352
74benzene-containing compound metabolic process (GO:0042537)3.53027947
75regulation of RNA export from nucleus (GO:0046831)3.49323844
76short-chain fatty acid metabolic process (GO:0046459)3.48654446
77exogenous drug catabolic process (GO:0042738)3.48623763
78glucuronate metabolic process (GO:0019585)3.46461439
79uronic acid metabolic process (GO:0006063)3.46461439
80serine family amino acid metabolic process (GO:0009069)3.45132636
81response to nitrosative stress (GO:0051409)3.44227003
82imidazole-containing compound metabolic process (GO:0052803)3.41950346
83positive regulation of receptor recycling (GO:0001921)3.40951781
84low-density lipoprotein particle remodeling (GO:0034374)3.40215611
85positive regulation of lipid catabolic process (GO:0050996)3.40154028
86aspartate family amino acid catabolic process (GO:0009068)3.38896959
87phospholipid homeostasis (GO:0055091)3.38745509
88plasma lipoprotein particle organization (GO:0071827)3.38563918
89cofactor catabolic process (GO:0051187)3.37172768
90drug transmembrane transport (GO:0006855)3.36749470
91definitive hemopoiesis (GO:0060216)3.35118084
92negative regulation of complement activation (GO:0045916)3.34795405
93acetyl-CoA metabolic process (GO:0006084)3.34187656
94iron ion import (GO:0097286)3.33743972
95epoxygenase P450 pathway (GO:0019373)3.31988219
96fibrinolysis (GO:0042730)3.31535376
97flavonoid metabolic process (GO:0009812)3.31534715
98regulation of bile acid biosynthetic process (GO:0070857)3.31402454
99erythrocyte development (GO:0048821)3.29396356
100positive regulation of fatty acid beta-oxidation (GO:0032000)3.29196102
101arginine metabolic process (GO:0006525)3.29026455
102cholesterol homeostasis (GO:0042632)3.28387457
103heme transport (GO:0015886)3.27175470
104protein-lipid complex subunit organization (GO:0071825)3.26541075
105sterol homeostasis (GO:0055092)3.23758723
106glycine metabolic process (GO:0006544)3.22249903
107ketone body metabolic process (GO:1902224)3.21878914
108histone H3-K9 demethylation (GO:0033169)3.20914933
109carboxylic acid catabolic process (GO:0046395)3.19544652
110organic acid catabolic process (GO:0016054)3.19544652
111negative regulation of lipase activity (GO:0060192)3.15430702
112N-terminal protein amino acid acetylation (GO:0006474)3.15358511
113negative regulation of protein activation cascade (GO:2000258)3.15231867
114protoporphyrinogen IX metabolic process (GO:0046501)3.12049209
115positive regulation of insulin receptor signaling pathway (GO:0046628)3.10122837
116fibroblast migration (GO:0010761)3.08488454
117opsonization (GO:0008228)3.08259609
118histone H3-K36 demethylation (GO:0070544)3.07899870
119cytoplasmic mRNA processing body assembly (GO:0033962)3.06002739
120oxygen transport (GO:0015671)3.04054451
121protein K11-linked deubiquitination (GO:0035871)3.03874054
122regulation of nucleobase-containing compound transport (GO:0032239)3.03785613
123protein K48-linked deubiquitination (GO:0071108)2.97938878
124detection of molecule of bacterial origin (GO:0032490)2.95497238
125pericardium development (GO:0060039)2.95334704
126import into cell (GO:0098657)2.95001299
127macroautophagy (GO:0016236)2.92111959
128cellular response to ethanol (GO:0071361)2.88151313
129myeloid cell development (GO:0061515)2.86949243
130negative regulation of anoikis (GO:2000811)2.85516378
131interkinetic nuclear migration (GO:0022027)2.84195995
132negative regulation of protein localization to plasma membrane (GO:1903077)2.83321726
133negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.83197318
134positive regulation of fibroblast migration (GO:0010763)2.82836603
135positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81476460
136histone mRNA catabolic process (GO:0071044)2.79624906
137nerve growth factor signaling pathway (GO:0038180)2.77486223
138interleukin-6-mediated signaling pathway (GO:0070102)2.75340689
139positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.74724567
140mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.74724567
141regulation of platelet aggregation (GO:0090330)2.74699886
142COPII vesicle coating (GO:0048208)2.74419946
143regulation of pigment cell differentiation (GO:0050932)2.74358757
144growth hormone receptor signaling pathway (GO:0060396)2.74065098
145porphyrin-containing compound biosynthetic process (GO:0006779)2.72862233
146erythrocyte maturation (GO:0043249)2.72294585
147gas transport (GO:0015669)2.71046808
148negative regulation of DNA repair (GO:0045738)2.70002492
149regulation of response to osmotic stress (GO:0047484)2.69568006
150regulation of protein polyubiquitination (GO:1902914)2.68153492
151regulation of transforming growth factor beta2 production (GO:0032909)2.68037372
152retrograde transport, vesicle recycling within Golgi (GO:0000301)2.65888254
153positive regulation of cardiac muscle hypertrophy (GO:0010613)2.63457074
154positive regulation of muscle hypertrophy (GO:0014742)2.63457074
155regulation of cAMP-dependent protein kinase activity (GO:2000479)2.62691775
156glycoprotein catabolic process (GO:0006516)2.61127188
157nuclear pore complex assembly (GO:0051292)2.58929849
158protein targeting to Golgi (GO:0000042)2.56037961
159negative regulation of humoral immune response (GO:0002921)2.55255046
160cellular response to epinephrine stimulus (GO:0071872)2.54884592
161establishment of protein localization to Golgi (GO:0072600)2.50650582
162embryonic process involved in female pregnancy (GO:0060136)2.48587331
163pathway-restricted SMAD protein phosphorylation (GO:0060389)2.48536357
164extracellular fibril organization (GO:0043206)2.47121583
165protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.47085466
166corticosteroid receptor signaling pathway (GO:0031958)2.46776241
167positive regulation of cellular response to insulin stimulus (GO:1900078)2.46617798
168cellular response to growth hormone stimulus (GO:0071378)2.45580435
169nuclear pore organization (GO:0006999)2.45149223
170regulation of cardiac muscle hypertrophy (GO:0010611)2.43100052
171positive regulation of macroautophagy (GO:0016239)2.42232886
172negative regulation of execution phase of apoptosis (GO:1900118)2.41427509
173negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)2.38934584
174regulation of muscle hypertrophy (GO:0014743)2.38613266
175protein targeting to vacuole (GO:0006623)2.38439731
176protein targeting to lysosome (GO:0006622)2.38439731
177establishment of protein localization to vacuole (GO:0072666)2.38439731
178cortical actin cytoskeleton organization (GO:0030866)2.38111957
179nucleus localization (GO:0051647)2.36192033
180histone lysine demethylation (GO:0070076)2.35376760
181blood vessel maturation (GO:0001955)2.34669340
182cellular response to gamma radiation (GO:0071480)2.34044555
183cellular response to virus (GO:0098586)2.33601373
184response to lead ion (GO:0010288)2.33395987
185platelet-derived growth factor receptor signaling pathway (GO:0048008)2.33312878
186sequestering of extracellular ligand from receptor (GO:0035581)2.32512031
187hypotonic response (GO:0006971)2.32132908
188peptidyl-lysine trimethylation (GO:0018023)2.30954140
189embryonic retina morphogenesis in camera-type eye (GO:0060059)2.30597105
190negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.29638232
191protein K63-linked deubiquitination (GO:0070536)2.29324724
192regulation of receptor recycling (GO:0001919)2.28525748
193fibril organization (GO:0097435)2.28478114
194negative regulation of fatty acid transport (GO:2000192)2.28232819
195positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.27487199
196phospholipid translocation (GO:0045332)2.27427750
197lipid translocation (GO:0034204)2.27427750
198negative regulation of NF-kappaB import into nucleus (GO:0042347)2.27400529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.40802456
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.10968385
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.17633331
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.05379094
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.45045062
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.83973339
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.78058836
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.36834524
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.26479543
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.91630626
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.87718291
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.74772378
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21164162
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.15144063
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.09983327
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.04569720
17TP53_16413492_ChIP-PET_HCT116_Human2.04446570
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.01778005
19EP300_21415370_ChIP-Seq_HL-1_Mouse1.86522155
20CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.80721170
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.77742122
22* FOXA2_19822575_ChIP-Seq_HepG2_Human1.71849626
23FOXM1_26456572_ChIP-Seq_MCF-7_Human1.69011842
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64568187
25HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.59176947
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58569448
27GATA1_19941826_ChIP-Seq_K562_Human1.58188962
28BRD4_25478319_ChIP-Seq_HGPS_Human1.57828146
29CTNNB1_20460455_ChIP-Seq_HCT116_Human1.56561136
30* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52940912
31TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.52760062
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51987586
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50113439
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49467650
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49131451
36TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.48530368
37GATA1_22025678_ChIP-Seq_K562_Human1.48442952
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43481318
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.42851370
40FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42537911
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41557383
42CJUN_26792858_Chip-Seq_BT549_Human1.41033533
43STAT3_23295773_ChIP-Seq_U87_Human1.36813495
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36528453
45* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33415513
46SMAD4_21799915_ChIP-Seq_A2780_Human1.33045538
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.29908231
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.29732224
49CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28422614
50NANOG_18555785_Chip-Seq_ESCs_Mouse1.27574096
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26967643
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.25995314
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24745529
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22108264
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22072036
56FUS_26573619_Chip-Seq_HEK293_Human1.20839513
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20583257
58* CLOCK_20551151_ChIP-Seq_293T_Human1.20358700
59CDX2_22108803_ChIP-Seq_LS180_Human1.19195208
60GATA2_19941826_ChIP-Seq_K562_Human1.18908068
61TAF15_26573619_Chip-Seq_HEK293_Human1.18872029
62FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18541468
63VDR_24787735_ChIP-Seq_THP-1_Human1.18251771
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15893633
65PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.15689327
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15553683
67TP63_23658742_ChIP-Seq_EP156T_Human1.14905753
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13017663
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12723786
70DROSHA_22980978_ChIP-Seq_HELA_Human1.12055873
71* HNF4A_19822575_ChIP-Seq_HepG2_Human1.09882996
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.09859132
73* GATA1_19941827_ChIP-Seq_MEL_Mouse1.08358464
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.06891856
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06747036
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06513379
77* P300_19829295_ChIP-Seq_ESCs_Human1.06455381
78E2F1_18555785_Chip-Seq_ESCs_Mouse1.05660051
79RUNX_20019798_ChIP-Seq_JUKART_Human1.05195306
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04455653
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.04233772
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04096729
83* IRF8_27001747_Chip-Seq_BMDM_Mouse1.03584338
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03239343
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03151154
86TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03125624
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02476862
88AR_21572438_ChIP-Seq_LNCaP_Human1.01977279
89TP53_18474530_ChIP-ChIP_U2OS_Human1.01734760
90OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01648128
91FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.01560842
92TRIM28_21343339_ChIP-Seq_HEK293_Human1.01191704
93TCF4_23295773_ChIP-Seq_U87_Human1.01146487
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01028796
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00892412
96SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00892412
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00349886
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98989643
99* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98787674
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.94577008
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93449836
102FOXO3_23340844_ChIP-Seq_DLD1_Human0.93009309
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92169411
104ERG_21242973_ChIP-ChIP_JURKAT_Human0.92104371
105MTF2_20144788_ChIP-Seq_MESCs_Mouse0.87718903
106* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87605656
107SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86674216
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85008849
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.85000516
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84862717
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.84642054
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84049169
113* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83510681
114* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83510681
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83422442
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82367627
117KDM2B_26808549_Chip-Seq_K562_Human0.80723692
118LXR_22292898_ChIP-Seq_THP-1_Human0.80509888
119PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79274640
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78658668
121NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.78218442
122DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76948613
123HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76089092
124* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.75524949
125CDX2_20551321_ChIP-Seq_CACO-2_Human0.73899605
126BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.73851245
127ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73767793
128HTT_18923047_ChIP-ChIP_STHdh_Human0.73735324
129WT1_25993318_ChIP-Seq_PODOCYTE_Human0.73119539
130CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72624593
131GATA4_25053715_ChIP-Seq_YYC3_Human0.72278145
132* SMAD4_21741376_ChIP-Seq_HESCs_Human0.71545175
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70460598
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.69472627
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.69465484
136PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.68914746
137EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.68202274
138MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.67708463
139ZNF263_19887448_ChIP-Seq_K562_Human0.66189414
140BCAT_22108803_ChIP-Seq_LS180_Human0.65819910
141CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.65557266
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.65499263
143KDM2B_26808549_Chip-Seq_SUP-B15_Human0.65370536
144EZH2_27294783_Chip-Seq_ESCs_Mouse0.65086622
145FOXA1_25552417_ChIP-Seq_VCAP_Human0.64797770
146SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.64660975
147RARB_27405468_Chip-Seq_BRAIN_Mouse0.64257504
148AHR_22903824_ChIP-Seq_MCF-7_Human0.64091675
149* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.64082338
150SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62548948
151KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.62303600
152RNF2_18974828_ChIP-Seq_MESCs_Mouse0.62279701
153EZH2_18974828_ChIP-Seq_MESCs_Mouse0.62279701
154CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.60670303
155EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.60316755
156GATA2_21666600_ChIP-Seq_HMVEC_Human0.59846470
157TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.58288646
158EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.58283841
159SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.58229559
160SCL_19346495_ChIP-Seq_HPC-7_Human0.58109786
161SUZ12_27294783_Chip-Seq_ESCs_Mouse0.58067131
162ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.57791059
163NFIB_24661679_ChIP-Seq_LUNG_Mouse0.57431107
164MYC_27129775_Chip-Seq_CORNEA_Mouse0.57361771
165GBX2_23144817_ChIP-Seq_PC3_Human0.57073443
166RXR_22108803_ChIP-Seq_LS180_Human0.57061601
167CREB1_26743006_Chip-Seq_LNCaP_Human0.56274007
168KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.56112898
169EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.55210607
170CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.54939496
171SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.54744195

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.82926171
2MP0005360_urolithiasis7.44647546
3MP0005085_abnormal_gallbladder_physiolo5.78596516
4MP0005365_abnormal_bile_salt5.48315042
5MP0008875_abnormal_xenobiotic_pharmacok5.00368307
6MP0000569_abnormal_digit_pigmentation4.99390811
7MP0003252_abnormal_bile_duct3.99716969
8MP0008438_abnormal_cutaneous_collagen3.97789955
9MP0008057_abnormal_DNA_replication3.55594166
10MP0010329_abnormal_lipoprotein_level3.40042066
11MP0003806_abnormal_nucleotide_metabolis3.30109205
12MP0005083_abnormal_biliary_tract3.14235826
13MP0008260_abnormal_autophagy3.00927215
14MP0003656_abnormal_erythrocyte_physiolo2.66615560
15MP0005332_abnormal_amino_acid2.62685236
16MP0009840_abnormal_foam_cell2.57172214
17MP0006054_spinal_hemorrhage2.47923130
18MP0003950_abnormal_plasma_membrane2.42340494
19MP0005409_darkened_coat_color2.42077776
20MP0003195_calcinosis2.34856403
21MP0004808_abnormal_hematopoietic_stem2.33664925
22MP0001666_abnormal_nutrient_absorption2.32916865
23MP0005275_abnormal_skin_tensile2.32894410
24MP0003091_abnormal_cell_migration2.17989847
25MP0001958_emphysema2.15653817
26MP0003191_abnormal_cellular_cholesterol2.08415877
27MP0002118_abnormal_lipid_homeostasis2.07804150
28MP0002138_abnormal_hepatobiliary_system2.06785026
29MP0003566_abnormal_cell_adhesion2.04910548
30MP0000609_abnormal_liver_physiology2.00102748
31MP0004019_abnormal_vitamin_homeostasis1.92210551
32MP0004272_abnormal_basement_membrane1.84483096
33MP0003172_abnormal_lysosome_physiology1.82080897
34MP0010352_gastrointestinal_tract_polyps1.77363530
35MP0000015_abnormal_ear_pigmentation1.75728828
36MP0001879_abnormal_lymphatic_vessel1.70196593
37MP0005503_abnormal_tendon_morphology1.66692010
38MP0002166_altered_tumor_susceptibility1.65235493
39MP0003221_abnormal_cardiomyocyte_apopto1.63477445
40MP0005076_abnormal_cell_differentiation1.62677720
41MP0005319_abnormal_enzyme/_coenzyme1.61990145
42MP0004883_abnormal_blood_vessel1.60291265
43MP0005584_abnormal_enzyme/coenzyme_acti1.59437005
44MP0005174_abnormal_tail_pigmentation1.59106131
45MP0004084_abnormal_cardiac_muscle1.57081517
46MP0003828_pulmonary_edema1.56681144
47MP0002009_preneoplasia1.56638173
48MP0003868_abnormal_feces_composition1.53630241
49MP0003279_aneurysm1.53553147
50MP0005397_hematopoietic_system_phenotyp1.51354395
51MP0001545_abnormal_hematopoietic_system1.51354395
52MP0003690_abnormal_glial_cell1.50810394
53MP0000767_abnormal_smooth_muscle1.43249252
54MP0003705_abnormal_hypodermis_morpholog1.41690229
55MP0005164_abnormal_response_to1.39520406
56MP0001915_intracranial_hemorrhage1.35913150
57MP0002396_abnormal_hematopoietic_system1.35614803
58MP0004484_altered_response_of1.28638027
59MP0000604_amyloidosis1.24990042
60MP0005621_abnormal_cell_physiology1.22288160
61MP0010307_abnormal_tumor_latency1.21580917
62MP0009643_abnormal_urine_homeostasis1.19831640
63MP0005187_abnormal_penis_morphology1.19732108
64MP0003011_delayed_dark_adaptation1.19633489
65MP0005623_abnormal_meninges_morphology1.13358734
66MP0003329_amyloid_beta_deposits1.11976180
67MP0009764_decreased_sensitivity_to1.09286001
68MP0003941_abnormal_skin_development1.06310899
69MP0004147_increased_porphyrin_level1.03690698
70MP0005388_respiratory_system_phenotype1.02866891
71MP0002133_abnormal_respiratory_system1.02866891
72MP0000013_abnormal_adipose_tissue1.02601668
73MP0003890_abnormal_embryonic-extraembry1.02448451
74MP0005451_abnormal_body_composition1.00916765
75MP0005636_abnormal_mineral_homeostasis1.00742963
76MP0001764_abnormal_homeostasis1.00542011
77MP0003186_abnormal_redox_activity0.99451144
78MP0009765_abnormal_xenobiotic_induced0.97943933
79MP0000733_abnormal_muscle_development0.97332494
80MP0002108_abnormal_muscle_morphology0.96749123
81MP0000598_abnormal_liver_morphology0.96192664
82MP0000749_muscle_degeneration0.95236205
83MP0009763_increased_sensitivity_to0.95221554
84MP0004885_abnormal_endolymph0.94880424
85MP0005647_abnormal_sex_gland0.94841932
86MP0004043_abnormal_pH_regulation0.94542748
87MP0002006_tumorigenesis0.94274940
88MP0008874_decreased_physiological_sensi0.94066935
89MP0002295_abnormal_pulmonary_circulatio0.93818864
90MP0004130_abnormal_muscle_cell0.93211878
91MP0002971_abnormal_brown_adipose0.92765431
92MP0001851_eye_inflammation0.91913712
93MP0005535_abnormal_body_temperature0.88625206
94MP0002128_abnormal_blood_circulation0.88141016
95MP0002060_abnormal_skin_morphology0.87423503
96MP0005384_cellular_phenotype0.87328779
97MP0008004_abnormal_stomach_pH0.86304518
98MP0002822_catalepsy0.86300464
99MP0010368_abnormal_lymphatic_system0.85258318
100MP0000920_abnormal_myelination0.84922303
101MP0004036_abnormal_muscle_relaxation0.84401389
102MP0002877_abnormal_melanocyte_morpholog0.81944081
103MP0001784_abnormal_fluid_regulation0.79851913
104MP0000427_abnormal_hair_cycle0.79111585
105MP0003075_altered_response_to0.78937349
106MP0005334_abnormal_fat_pad0.78878332
107MP0002086_abnormal_extraembryonic_tissu0.77625710
108MP0003943_abnormal_hepatobiliary_system0.77604304
109MP0000371_diluted_coat_color0.76920735
110MP0003300_gastrointestinal_ulcer0.75821071
111MP0009703_decreased_birth_body0.75731072
112MP0009642_abnormal_blood_homeostasis0.75321947
113MP0003453_abnormal_keratinocyte_physiol0.74461743
114MP0002925_abnormal_cardiovascular_devel0.74305661
115MP0005023_abnormal_wound_healing0.73480294
116MP0002269_muscular_atrophy0.71950758
117MP0002078_abnormal_glucose_homeostasis0.71082726
118MP0010630_abnormal_cardiac_muscle0.70854613
119MP0000428_abnormal_craniofacial_morphol0.70563482
120MP0002254_reproductive_system_inflammat0.70440150
121MP0001614_abnormal_blood_vessel0.69225198
122MP0010678_abnormal_skin_adnexa0.69158159
123MP0008469_abnormal_protein_level0.69140137
124MP0003115_abnormal_respiratory_system0.68639646
125MP0000266_abnormal_heart_morphology0.67657617
126MP0002896_abnormal_bone_mineralization0.66470812
127MP0005595_abnormal_vascular_smooth0.66058494
128MP0001661_extended_life_span0.65668684
129MP0005058_abnormal_lysosome_morphology0.65135911
130MP0002088_abnormal_embryonic_growth/wei0.64708261
131MP0002928_abnormal_bile_duct0.64043610
132MP0003763_abnormal_thymus_physiology0.63446473
133MP0009697_abnormal_copulation0.63013972
134MP0000858_altered_metastatic_potential0.62780413
135MP0004134_abnormal_chest_morphology0.62648128
136MP0001756_abnormal_urination0.62582818
137MP0003633_abnormal_nervous_system0.62287453
138MP0004264_abnormal_extraembryonic_tissu0.62252608
139MP0002168_other_aberrant_phenotype0.61543126
140MP0003303_peritoneal_inflammation0.61195841
141MP0005376_homeostasis/metabolism_phenot0.60124544
142MP0002090_abnormal_vision0.59681077
143MP0004142_abnormal_muscle_tone0.59437863
144MP0005464_abnormal_platelet_physiology0.58242552
145MP0005666_abnormal_adipose_tissue0.56118583
146MP0000639_abnormal_adrenal_gland0.55769025
147MP0005266_abnormal_metabolism0.54823214
148MP0002136_abnormal_kidney_physiology0.54130382
149MP0001440_abnormal_grooming_behavior0.53557377
150MP0009384_cardiac_valve_regurgitation0.51766700
151MP0009780_abnormal_chondrocyte_physiolo0.51090278
152MP0004858_abnormal_nervous_system0.51046510
153MP0003638_abnormal_response/metabolism_0.50126106
154MP0008872_abnormal_physiological_respon0.49835474
155MP0001765_abnormal_ion_homeostasis0.49036222
156MP0004859_abnormal_synaptic_plasticity0.48429899
157MP0008873_increased_physiological_sensi0.47874794
158MP0005670_abnormal_white_adipose0.47187595
159MP0002332_abnormal_exercise_endurance0.45031084
160MP0002970_abnormal_white_adipose0.44645774
161MP0003631_nervous_system_phenotype0.44131087
162MP0005166_decreased_susceptibility_to0.43942954
163MP0005248_abnormal_Harderian_gland0.43901133
164MP0005448_abnormal_energy_balance0.43759310
165MP0006035_abnormal_mitochondrial_morpho0.43531016
166MP0008961_abnormal_basal_metabolism0.43481201
167MP0002229_neurodegeneration0.42883750
168MP0006036_abnormal_mitochondrial_physio0.42625152
169MP0005167_abnormal_blood-brain_barrier0.41627050
170MP0003045_fibrosis0.41612430
171MP0002064_seizures0.41481965
172MP0009115_abnormal_fat_cell0.40591797
173MP0003632_abnormal_nervous_system0.38991451
174MP0001502_abnormal_circadian_rhythm0.38937211
175MP0000230_abnormal_systemic_arterial0.38883084
176MP0005408_hypopigmentation0.36759965
177MP0005551_abnormal_eye_electrophysiolog0.36581666
178MP0003953_abnormal_hormone_level0.36049210

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.00019435
2Intrahepatic cholestasis (HP:0001406)6.46696504
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.36496753
4Xanthomatosis (HP:0000991)5.62659883
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.61070447
6Prolonged partial thromboplastin time (HP:0003645)5.45449519
7Hypobetalipoproteinemia (HP:0003563)5.16003994
8Hyperlipoproteinemia (HP:0010980)5.07931483
9Complement deficiency (HP:0004431)4.66310076
10Papillary thyroid carcinoma (HP:0002895)4.44412244
11Hypochromic microcytic anemia (HP:0004840)4.33889115
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.25857907
13Joint hemorrhage (HP:0005261)4.21700525
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.11808400
15Hypolipoproteinemia (HP:0010981)3.88683447
16Osteolytic defects of the hand bones (HP:0009699)3.76426876
17Osteolytic defects of the phalanges of the hand (HP:0009771)3.76426876
18Epidermoid cyst (HP:0200040)3.75567130
19Poikilocytosis (HP:0004447)3.75501661
20Hyperammonemia (HP:0001987)3.74849906
21Abnormality of the common coagulation pathway (HP:0010990)3.71377872
22Ketosis (HP:0001946)3.66308847
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.66095769
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.63302317
25Peritonitis (HP:0002586)3.60724741
26Hypercholesterolemia (HP:0003124)3.58714606
27Acanthocytosis (HP:0001927)3.51750771
28Hypoalphalipoproteinemia (HP:0003233)3.49116029
29Abnormality of the heme biosynthetic pathway (HP:0010472)3.48074843
30Abnormality of glycine metabolism (HP:0010895)3.46715428
31Abnormality of serine family amino acid metabolism (HP:0010894)3.46715428
32Hyperglycinemia (HP:0002154)3.46057820
33Fat malabsorption (HP:0002630)3.40938015
34Hyperglycinuria (HP:0003108)3.40780819
35Hyperbilirubinemia (HP:0002904)3.39665954
36Aortic aneurysm (HP:0004942)3.30753478
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.30299423
38Arterial tortuosity (HP:0005116)3.29592653
39Microcytic anemia (HP:0001935)3.27682000
40Abnormality of complement system (HP:0005339)3.24398990
41Aortic dissection (HP:0002647)3.19686458
42Vascular tortuosity (HP:0004948)3.17862948
43Delayed CNS myelination (HP:0002188)3.12407451
44Cholelithiasis (HP:0001081)3.12332213
45Abnormality of methionine metabolism (HP:0010901)3.09269640
46Abnormal gallbladder morphology (HP:0012437)3.05722241
47Conjugated hyperbilirubinemia (HP:0002908)3.04880220
48Premature rupture of membranes (HP:0001788)2.99006624
49Absent frontal sinuses (HP:0002688)2.93416299
50Conjunctival telangiectasia (HP:0000524)2.86922973
51Hepatocellular carcinoma (HP:0001402)2.86742440
52Reticulocytosis (HP:0001923)2.82683427
53Thyroid carcinoma (HP:0002890)2.82561943
54Abnormality of the intrinsic pathway (HP:0010989)2.79352574
55Abnormality of the vasculature of the conjunctiva (HP:0008054)2.78454050
56Hypoglycemic coma (HP:0001325)2.77456624
57Abnormal gallbladder physiology (HP:0012438)2.76084750
58Cholecystitis (HP:0001082)2.76084750
59Protrusio acetabuli (HP:0003179)2.75571188
60Myocardial infarction (HP:0001658)2.72514741
61Overgrowth (HP:0001548)2.66638720
62Gout (HP:0001997)2.64951020
63Ketoacidosis (HP:0001993)2.64796258
64Mitral valve prolapse (HP:0001634)2.62372771
65Spontaneous abortion (HP:0005268)2.56682641
66Subacute progressive viral hepatitis (HP:0006572)2.55625905
67Hemorrhage of the eye (HP:0011885)2.54981580
68Abnormality of fatty-acid metabolism (HP:0004359)2.53650960
69Vascular calcification (HP:0004934)2.50419705
70Back pain (HP:0003418)2.50260805
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.48839540
72Status epilepticus (HP:0002133)2.45515134
73Wormian bones (HP:0002645)2.45373874
74Abnormality of the fingertips (HP:0001211)2.44121802
75Glucose intolerance (HP:0000833)2.43856273
76Spondylolisthesis (HP:0003302)2.42066424
77Steatorrhea (HP:0002570)2.40816481
78Metabolic acidosis (HP:0001942)2.39789669
79Abnormality of purine metabolism (HP:0004352)2.39266719
80Abnormality of nucleobase metabolism (HP:0010932)2.37837511
81Syringomyelia (HP:0003396)2.37400264
82Spinal cord lesions (HP:0100561)2.37400264
83Amyloidosis (HP:0011034)2.35998689
84Skin nodule (HP:0200036)2.35696800
85Abnormality of pyrimidine metabolism (HP:0004353)2.34979097
86Mitral stenosis (HP:0001718)2.34804252
87Dilatation of the ascending aorta (HP:0005111)2.33229027
88Sensorimotor neuropathy (HP:0007141)2.33220257
89Resting tremor (HP:0002322)2.30020474
90Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.29459362
91Heterotopia (HP:0002282)2.28348475
92Curly hair (HP:0002212)2.25614295
93Abnormality of the gallbladder (HP:0005264)2.24589129
94Macroorchidism (HP:0000053)2.24275930
95Cardiovascular calcification (HP:0011915)2.24047670
96Rickets (HP:0002748)2.21933926
97Acute myeloid leukemia (HP:0004808)2.20796900
98Menorrhagia (HP:0000132)2.19837044
99Hydroxyprolinuria (HP:0003080)2.18438521
100Abnormality of proline metabolism (HP:0010907)2.18438521
101Orthostatic hypotension (HP:0001278)2.17214821
102Spontaneous hematomas (HP:0007420)2.16193000
103Periodontitis (HP:0000704)2.16183418
104Enlarged kidneys (HP:0000105)2.14431825
105Submucous cleft hard palate (HP:0000176)2.14418115
106Hyperkalemia (HP:0002153)2.11738928
107Malnutrition (HP:0004395)2.09833966
108Neonatal onset (HP:0003623)2.08757083
109Soft skin (HP:0000977)2.07959300
110Gingival bleeding (HP:0000225)2.07037545
111Esophageal varix (HP:0002040)2.06791093
112Spastic diplegia (HP:0001264)2.06670606
113Narrow palate (HP:0000189)2.06071247
114Abnormality of serum amino acid levels (HP:0003112)2.01215437
115Irritability (HP:0000737)2.01045940
116Neurofibrillary tangles (HP:0002185)2.00460605
117Systemic lupus erythematosus (HP:0002725)1.99811315
118Hypophosphatemic rickets (HP:0004912)1.99740841
119Confusion (HP:0001289)1.97909832
120Gastrointestinal infarctions (HP:0005244)1.95594279
121Polycythemia (HP:0001901)1.94988927
122Recurrent gram-negative bacterial infections (HP:0005420)1.92927479
123Delayed closure of the anterior fontanelle (HP:0001476)1.92632813
124Alkalosis (HP:0001948)1.92447313
125Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.91337103
126Turricephaly (HP:0000262)1.90476280
127Abnormal glucose tolerance (HP:0001952)1.89350320
128Vertebral arch anomaly (HP:0008438)1.88980792
129Hematochezia (HP:0002573)1.86493905
130Thoracolumbar scoliosis (HP:0002944)1.84740865
131Cerebral inclusion bodies (HP:0100314)1.84533064
132Bladder carcinoma (HP:0002862)1.83455009
133Bladder neoplasm (HP:0009725)1.83455009
134Increased mean platelet volume (HP:0011877)1.82346930
135Metaphyseal dysplasia (HP:0100255)1.80879405
136Pseudobulbar signs (HP:0002200)1.80672606
137Transitional cell carcinoma of the bladder (HP:0006740)1.80134948
138Cystic hygroma (HP:0000476)1.79693490
139Asymmetry of the thorax (HP:0001555)1.78818107
140Dicarboxylic aciduria (HP:0003215)1.77261923
141Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77261923
142T lymphocytopenia (HP:0005403)1.76865829
143Pulmonic stenosis (HP:0001642)1.76810871
144Slow saccadic eye movements (HP:0000514)1.76248901
145Menstrual irregularities (HP:0000858)1.75049585
146Abnormality of the Achilles tendon (HP:0005109)1.74373025
147Truncal obesity (HP:0001956)1.73663609
148Difficulty running (HP:0009046)1.73329044
149Hypoglycemic seizures (HP:0002173)1.71754294
150Joint laxity (HP:0001388)1.71075498
151Scanning speech (HP:0002168)1.70809530
152Aneurysm (HP:0002617)1.70661624
153Short nail (HP:0001799)1.70057551
154Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69630535
155Postural instability (HP:0002172)1.69476729
156Volvulus (HP:0002580)1.68302993
157Vomiting (HP:0002013)1.66904804
158Bile duct proliferation (HP:0001408)1.66511746
159Abnormal biliary tract physiology (HP:0012439)1.66511746
160Biliary tract neoplasm (HP:0100574)1.66503397
161Global brain atrophy (HP:0002283)1.65902788
162Ankyloglossia (HP:0010296)1.65563624
163Autoamputation (HP:0001218)1.65374699
164Hypochromic anemia (HP:0001931)1.65192276
165Thrombophlebitis (HP:0004418)1.65007780
166Intention tremor (HP:0002080)1.64972358
167Tetraparesis (HP:0002273)1.64960280
168Deep philtrum (HP:0002002)1.64473368
169Flat acetabular roof (HP:0003180)1.64283374
170Fair hair (HP:0002286)1.64181588
171Termporal pattern (HP:0011008)1.63254844
172Insidious onset (HP:0003587)1.63254844
173Subaortic stenosis (HP:0001682)1.60337741
174Abnormality of the left ventricular outflow tract (HP:0011103)1.60337741
175Stroke (HP:0001297)1.60230225
176Tetraplegia (HP:0002445)1.60227802
177Ankle contracture (HP:0006466)1.60160220
178Abnormality of T cell number (HP:0011839)1.60101093
179Abnormality of the frontal sinuses (HP:0002687)1.59950808
180Glomerulonephritis (HP:0000099)1.59545539
181Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.59047074
182Abnormal enzyme/coenzyme activity (HP:0012379)1.58441195
183Thickened calvaria (HP:0002684)1.58115089
184Long eyelashes (HP:0000527)1.58021577
185Large earlobe (HP:0009748)1.57584603
186Abnormal foot bone ossification (HP:0010675)1.56579119
187Cubitus valgus (HP:0002967)1.56415460
188Cerebral aneurysm (HP:0004944)1.56114983
189Malignant gastrointestinal tract tumors (HP:0006749)1.54997288
190Gastrointestinal carcinoma (HP:0002672)1.54997288

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.77971392
2SIK13.21042836
3AKT32.82587539
4BCKDK2.70360572
5FGFR42.43319352
6TRIB32.31311040
7EPHB12.24152239
8BRD42.23397018
9MAP2K42.11678121
10NEK92.11047207
11STK41.87947917
12CDK121.82464546
13ERN11.82245462
14ICK1.79111795
15PKN21.76289623
16GRK61.66542625
17RIPK11.63981711
18STK31.63528998
19STK38L1.58075559
20TAOK31.57988961
21EEF2K1.56210256
22MAPK151.55119261
23FGFR21.47400969
24PLK21.46889800
25LATS11.42884417
26DYRK31.41275629
27MAPK111.40487162
28FGFR31.39814898
29DAPK21.39353507
30MAP3K71.38758730
31PTK61.38622233
32ACVR1B1.32231621
33YES11.28719184
34STK241.28407678
35NTRK11.28183351
36DMPK1.25573326
37STK381.24934100
38EPHA41.24636629
39ERBB41.23774676
40WNK41.23596688
41MAP3K31.22774891
42SGK31.22330216
43PDGFRB1.21958631
44FRK1.16900715
45BMX1.16729447
46NLK1.15643745
47JAK21.15395230
48STK391.14636011
49PIM11.11300639
50CAMK1G1.10611120
51KSR21.08876258
52CSK1.07675174
53PRKCH1.07573648
54MAP3K101.03001451
55SGK2231.01647053
56SGK4941.01647053
57MELK1.01218402
58OXSR10.99880768
59MYLK0.99705909
60PDPK10.99430621
61TYRO30.97270833
62PRKAA20.95327249
63PRKCZ0.94325800
64MAP3K90.93503180
65RET0.92334671
66CAMKK10.91990548
67HIPK20.91049307
68TTN0.90672450
69TNIK0.89601712
70TYK20.89224481
71CDK60.88551262
72KSR10.88280347
73MAPK120.88271594
74PTK20.87702921
75ERBB20.87458839
76SGK20.86856704
77SCYL20.85653074
78PDK10.84658705
79ERBB30.83918419
80INSRR0.82894859
81PAK30.82642978
82WNK10.81690599
83RAF10.81556200
84TBK10.80895338
85MAP3K60.80573189
86MET0.80271779
87GRK50.79761921
88PBK0.79272943
89PTK2B0.78291803
90MAP3K20.77926799
91PKN10.77657436
92PAK60.76719626
93FES0.75911318
94GSK3A0.75087156
95TRPM70.75024795
96BLK0.74746831
97PINK10.74571721
98BRSK20.74359168
99MAP2K30.74072708
100FGR0.71663087
101NUAK10.71000748
102PRKD20.70517267
103PRKAA10.69524540
104CAMK1D0.69090143
105MAPK70.67758590
106MAP3K130.67666084
107PRKCQ0.67001020
108PRPF4B0.65989573
109JAK10.65464143
110TAOK20.62636302
111PRKACG0.62579559
112MAP3K50.61773179
113JAK30.61476996
114MAP3K10.61128685
115MST1R0.59740722
116EGFR0.59739734
117TAOK10.59257738
118SIK20.58958663
119TGFBR20.58942432
120PIK3CG0.58713767
121EIF2AK30.57680453
122PDGFRA0.57555572
123ABL20.57437162
124BMPR20.56563819
125DYRK1A0.55769513
126MAP2K10.54367763
127OBSCN0.53683198
128STK110.53288597
129DYRK1B0.51811382
130MAP3K40.51595701
131PLK30.51568905
132MAPK40.51085132
133MAP3K140.51052772
134MARK20.50555287
135IKBKE0.50459975
136DDR20.49572867
137MAP2K60.49159654
138NTRK30.48886326
139CAMK40.48293968
140MTOR0.48070995
141TEC0.47753204
142FLT30.47044838
143SGK10.46960592
144RPS6KA30.45351695
145CSNK1G20.44976517
146PNCK0.43812108
147SYK0.43727322
148MST40.39938501
149FGFR10.37990322

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.41302320
2Primary bile acid biosynthesis_Homo sapiens_hsa001204.06499559
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.11754656
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.04745606
5Arginine biosynthesis_Homo sapiens_hsa002202.94633942
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.57623480
7Tryptophan metabolism_Homo sapiens_hsa003802.48023840
8Complement and coagulation cascades_Homo sapiens_hsa046102.47070294
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.29949817
10Fatty acid degradation_Homo sapiens_hsa000712.24949900
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24380603
12Butanoate metabolism_Homo sapiens_hsa006502.21411641
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16035299
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.11455662
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05505144
16Non-small cell lung cancer_Homo sapiens_hsa052232.01068075
17Chemical carcinogenesis_Homo sapiens_hsa052041.89908657
18Bile secretion_Homo sapiens_hsa049761.88695632
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.88059548
20PPAR signaling pathway_Homo sapiens_hsa033201.87228130
21Peroxisome_Homo sapiens_hsa041461.85167936
22Chronic myeloid leukemia_Homo sapiens_hsa052201.84687663
23Circadian rhythm_Homo sapiens_hsa047101.78344321
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76245366
25Fatty acid metabolism_Homo sapiens_hsa012121.75553181
26Histidine metabolism_Homo sapiens_hsa003401.74294353
27Endometrial cancer_Homo sapiens_hsa052131.73186283
28Propanoate metabolism_Homo sapiens_hsa006401.68218071
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.67961651
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66846572
31Pancreatic cancer_Homo sapiens_hsa052121.66808194
32Caffeine metabolism_Homo sapiens_hsa002321.60565244
33FoxO signaling pathway_Homo sapiens_hsa040681.58060951
34Renal cell carcinoma_Homo sapiens_hsa052111.55504928
35ABC transporters_Homo sapiens_hsa020101.53864471
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53722851
37Platelet activation_Homo sapiens_hsa046111.53249237
38Retinol metabolism_Homo sapiens_hsa008301.46625464
39Inositol phosphate metabolism_Homo sapiens_hsa005621.44040834
40Staphylococcus aureus infection_Homo sapiens_hsa051501.44012220
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43626341
42Focal adhesion_Homo sapiens_hsa045101.42858323
43beta-Alanine metabolism_Homo sapiens_hsa004101.41874190
44Proteoglycans in cancer_Homo sapiens_hsa052051.38016419
45Prolactin signaling pathway_Homo sapiens_hsa049171.37931583
46Malaria_Homo sapiens_hsa051441.37103546
47Adherens junction_Homo sapiens_hsa045201.35756449
48MicroRNAs in cancer_Homo sapiens_hsa052061.34639359
49Small cell lung cancer_Homo sapiens_hsa052221.33472282
50Glioma_Homo sapiens_hsa052141.31136179
51Prostate cancer_Homo sapiens_hsa052151.30318513
52mTOR signaling pathway_Homo sapiens_hsa041501.29466944
53Vitamin B6 metabolism_Homo sapiens_hsa007501.28357394
54Selenocompound metabolism_Homo sapiens_hsa004501.27319118
55Thyroid cancer_Homo sapiens_hsa052161.25653032
56ECM-receptor interaction_Homo sapiens_hsa045121.25071245
57Phenylalanine metabolism_Homo sapiens_hsa003601.24808929
58Sulfur metabolism_Homo sapiens_hsa009201.20253892
59Tyrosine metabolism_Homo sapiens_hsa003501.18286892
60Starch and sucrose metabolism_Homo sapiens_hsa005001.17527689
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15705537
62Steroid biosynthesis_Homo sapiens_hsa001001.15290806
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14585054
64Drug metabolism - other enzymes_Homo sapiens_hsa009831.14173086
65Pyruvate metabolism_Homo sapiens_hsa006201.13453040
66B cell receptor signaling pathway_Homo sapiens_hsa046621.10398933
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09079889
68Renin secretion_Homo sapiens_hsa049241.08173187
69Thyroid hormone signaling pathway_Homo sapiens_hsa049191.08121830
70Neurotrophin signaling pathway_Homo sapiens_hsa047221.07364448
71Amoebiasis_Homo sapiens_hsa051461.06446896
72Fatty acid elongation_Homo sapiens_hsa000621.05925369
73Leukocyte transendothelial migration_Homo sapiens_hsa046701.05115868
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01933742
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01135494
76Jak-STAT signaling pathway_Homo sapiens_hsa046301.00046054
77ErbB signaling pathway_Homo sapiens_hsa040120.99407136
78Lysine degradation_Homo sapiens_hsa003100.97958612
79Long-term potentiation_Homo sapiens_hsa047200.96769296
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94144789
81Hepatitis C_Homo sapiens_hsa051600.93357291
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93263975
83Fat digestion and absorption_Homo sapiens_hsa049750.93021482
84Glycerolipid metabolism_Homo sapiens_hsa005610.92864509
85Hepatitis B_Homo sapiens_hsa051610.90807374
86Acute myeloid leukemia_Homo sapiens_hsa052210.88061221
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87973971
88TGF-beta signaling pathway_Homo sapiens_hsa043500.86816321
89Measles_Homo sapiens_hsa051620.86451291
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86156449
91Melanoma_Homo sapiens_hsa052180.85543402
92Biosynthesis of amino acids_Homo sapiens_hsa012300.83822938
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.83310266
94Osteoclast differentiation_Homo sapiens_hsa043800.83212529
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.82363185
96Gap junction_Homo sapiens_hsa045400.82184099
97African trypanosomiasis_Homo sapiens_hsa051430.81452858
98Fatty acid biosynthesis_Homo sapiens_hsa000610.81305632
99Colorectal cancer_Homo sapiens_hsa052100.80933846
100Long-term depression_Homo sapiens_hsa047300.80543280
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.79391165
102Arginine and proline metabolism_Homo sapiens_hsa003300.79189973
103Carbon metabolism_Homo sapiens_hsa012000.79134875
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.78412882
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77907004
106GnRH signaling pathway_Homo sapiens_hsa049120.75668152
107Dilated cardiomyopathy_Homo sapiens_hsa054140.74322304
108Vitamin digestion and absorption_Homo sapiens_hsa049770.71262627
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.70147919
110HIF-1 signaling pathway_Homo sapiens_hsa040660.69518112
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.69270276
112VEGF signaling pathway_Homo sapiens_hsa043700.68881307
113Toxoplasmosis_Homo sapiens_hsa051450.67080581
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66643687
115Pathways in cancer_Homo sapiens_hsa052000.66478251
116Estrogen signaling pathway_Homo sapiens_hsa049150.66095014
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65203353
118T cell receptor signaling pathway_Homo sapiens_hsa046600.64337604
119Influenza A_Homo sapiens_hsa051640.63333313
120Regulation of autophagy_Homo sapiens_hsa041400.62253615
121Glutathione metabolism_Homo sapiens_hsa004800.61007655
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60048098
123Tight junction_Homo sapiens_hsa045300.59125797
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58079124
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57847704
126Chemokine signaling pathway_Homo sapiens_hsa040620.57428184
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56826736
128Sulfur relay system_Homo sapiens_hsa041220.56751350
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56425560
130Cholinergic synapse_Homo sapiens_hsa047250.55312953
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54441081
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54250169
133Oxytocin signaling pathway_Homo sapiens_hsa049210.53650141
134Notch signaling pathway_Homo sapiens_hsa043300.53247939
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52765726
136TNF signaling pathway_Homo sapiens_hsa046680.51369738
137Folate biosynthesis_Homo sapiens_hsa007900.50823730
138Rap1 signaling pathway_Homo sapiens_hsa040150.50245128
139p53 signaling pathway_Homo sapiens_hsa041150.48643227
140Hedgehog signaling pathway_Homo sapiens_hsa043400.48463954
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.47310546
142Prion diseases_Homo sapiens_hsa050200.41929455
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41769459
144Insulin resistance_Homo sapiens_hsa049310.40803582
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38867136
146Maturity onset diabetes of the young_Homo sapiens_hsa049500.38378203
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.34638417
148Dorso-ventral axis formation_Homo sapiens_hsa043200.32267996
149Metabolic pathways_Homo sapiens_hsa011000.22867073
150Fructose and mannose metabolism_Homo sapiens_hsa000510.20208509
151Glucagon signaling pathway_Homo sapiens_hsa049220.20039491
152AMPK signaling pathway_Homo sapiens_hsa041520.18230437
153Pentose phosphate pathway_Homo sapiens_hsa000300.17236252
154Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16979222
155Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15056295
156GABAergic synapse_Homo sapiens_hsa047270.13069363
157Ovarian steroidogenesis_Homo sapiens_hsa049130.12785523
158Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12717387
159alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10738878
160Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09409386
161Thyroid hormone synthesis_Homo sapiens_hsa049180.09284161
162Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.06117929
163Salivary secretion_Homo sapiens_hsa049700.02168317
164Type II diabetes mellitus_Homo sapiens_hsa049300.02125976
165Galactose metabolism_Homo sapiens_hsa000520.01370374
166Insulin signaling pathway_Homo sapiens_hsa049100.01249123
167Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.01046214
168Mineral absorption_Homo sapiens_hsa049780.00894869
169Linoleic acid metabolism_Homo sapiens_hsa005910.00414002
170Gastric acid secretion_Homo sapiens_hsa04971-0.0483317
171Phosphatidylinositol signaling system_Homo sapiens_hsa04070-0.0444248
172Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0436717
173Glutamatergic synapse_Homo sapiens_hsa04724-0.0421885
174Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0286947
175Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0280418
176Choline metabolism in cancer_Homo sapiens_hsa05231-0.0253359
177Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0217187
178Phospholipase D signaling pathway_Homo sapiens_hsa04072-0.0200615
179Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0176803

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