TBCK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.27906126
2negative regulation of dendrite morphogenesis (GO:0050774)4.60845097
3presynaptic membrane organization (GO:0097090)4.54638365
4neural tube formation (GO:0001841)4.30653792
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.29348862
6behavioral response to nicotine (GO:0035095)4.18706266
7postsynaptic membrane organization (GO:0001941)4.08231070
8epithelial cilium movement (GO:0003351)3.66860087
9negative regulation of dendrite development (GO:2000171)3.65216035
10intraciliary transport (GO:0042073)3.60959975
11nucleobase catabolic process (GO:0046113)3.50972938
12mesenchymal cell differentiation involved in renal system development (GO:2001012)3.49684696
13mesenchymal cell differentiation involved in kidney development (GO:0072161)3.49684696
14cell differentiation involved in metanephros development (GO:0072202)3.48792739
15central nervous system projection neuron axonogenesis (GO:0021952)3.45166768
16neuron cell-cell adhesion (GO:0007158)3.37467871
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.37102603
18central nervous system neuron axonogenesis (GO:0021955)3.33525303
19mannosylation (GO:0097502)3.33314269
20negative regulation of keratinocyte proliferation (GO:0010839)3.29951152
21protein localization to cilium (GO:0061512)3.28744675
22ER overload response (GO:0006983)3.28254514
23establishment of protein localization to Golgi (GO:0072600)3.28181546
24startle response (GO:0001964)3.27998355
25sympathetic nervous system development (GO:0048485)3.27721349
26neurotransmitter-gated ion channel clustering (GO:0072578)3.22639799
27fucose catabolic process (GO:0019317)3.22227715
28L-fucose metabolic process (GO:0042354)3.22227715
29L-fucose catabolic process (GO:0042355)3.22227715
30photoreceptor cell maintenance (GO:0045494)3.21896019
31histamine secretion (GO:0001821)3.19528419
32detection of light stimulus involved in sensory perception (GO:0050962)3.16182792
33detection of light stimulus involved in visual perception (GO:0050908)3.16182792
34diterpenoid biosynthetic process (GO:0016102)3.15540045
35negative regulation of glycogen biosynthetic process (GO:0045719)3.15184477
36cilium morphogenesis (GO:0060271)3.15110684
37negative regulation of neurotransmitter secretion (GO:0046929)3.13885981
38cilium organization (GO:0044782)3.13306496
39cilium assembly (GO:0042384)3.11630248
40negative regulation of mast cell activation (GO:0033004)3.11333966
41dentate gyrus development (GO:0021542)3.09470836
42cilium movement (GO:0003341)3.07582910
43regulation of sarcomere organization (GO:0060297)3.05973575
44cilium or flagellum-dependent cell motility (GO:0001539)3.05425376
45gamma-aminobutyric acid transport (GO:0015812)3.05161006
46retinal ganglion cell axon guidance (GO:0031290)3.03596629
47negative regulation of cytosolic calcium ion concentration (GO:0051481)3.02881339
48facial nerve structural organization (GO:0021612)3.02653641
49somite development (GO:0061053)3.00216984
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.99164270
51serotonin receptor signaling pathway (GO:0007210)2.99118571
52limb bud formation (GO:0060174)2.96821661
53regulation of cilium movement (GO:0003352)2.96611040
54protein localization to cytoskeleton (GO:0044380)2.94986545
55negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91765464
56behavioral response to ethanol (GO:0048149)2.91442203
57inner ear receptor cell differentiation (GO:0060113)2.88352025
58inositol phosphate catabolic process (GO:0071545)2.87679899
59viral protein processing (GO:0019082)2.87657418
60microtubule depolymerization (GO:0007019)2.86934208
61negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86157087
62negative regulation of translation, ncRNA-mediated (GO:0040033)2.86157087
63regulation of translation, ncRNA-mediated (GO:0045974)2.86157087
64protein localization to synapse (GO:0035418)2.86091748
65cerebral cortex radially oriented cell migration (GO:0021799)2.84589355
66neuronal action potential (GO:0019228)2.83437053
67head development (GO:0060322)2.83385647
68terpenoid biosynthetic process (GO:0016114)2.82213447
69positive regulation of developmental pigmentation (GO:0048087)2.81261221
70mechanoreceptor differentiation (GO:0042490)2.80339657
71transmission of nerve impulse (GO:0019226)2.79793964
72response to pheromone (GO:0019236)2.79485748
73retinal cone cell development (GO:0046549)2.79395799
74positive regulation of chemokine secretion (GO:0090197)2.79238974
75neuronal action potential propagation (GO:0019227)2.75112395
76protein localization to microtubule cytoskeleton (GO:0072698)2.74875950
77protein prenylation (GO:0018342)2.74192881
78prenylation (GO:0097354)2.74192881
79cell differentiation involved in kidney development (GO:0061005)2.74103035
80indolalkylamine metabolic process (GO:0006586)2.73794658
81protein targeting to Golgi (GO:0000042)2.73116600
82tryptophan catabolic process (GO:0006569)2.72714291
83indole-containing compound catabolic process (GO:0042436)2.72714291
84indolalkylamine catabolic process (GO:0046218)2.72714291
85reflex (GO:0060004)2.71636767
86negative regulation of glycogen metabolic process (GO:0070874)2.71380197
87negative regulation of neurotransmitter transport (GO:0051589)2.71024111
88calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.70744241
89regulation of pigment cell differentiation (GO:0050932)2.67659064
90axonal fasciculation (GO:0007413)2.67493604
91nucleotide transmembrane transport (GO:1901679)2.66833918
92DNA ligation (GO:0006266)2.66114835
93histamine transport (GO:0051608)2.64591296
94limb development (GO:0060173)2.64316158
95appendage development (GO:0048736)2.64316158
96positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.64132655
97developmental pigmentation (GO:0048066)2.63108955
98cellular response to sterol (GO:0036315)2.62501479
99centriole replication (GO:0007099)2.62264948
100regulation of action potential (GO:0098900)2.61121089
101positive regulation of oligodendrocyte differentiation (GO:0048714)2.61012970
102axoneme assembly (GO:0035082)2.60810414
103protein polyglutamylation (GO:0018095)2.58896436
104microtubule anchoring (GO:0034453)2.58725183
105acrosome assembly (GO:0001675)2.58515308
106cyclic nucleotide catabolic process (GO:0009214)2.58242749
107cellular component assembly involved in morphogenesis (GO:0010927)2.58086061
108cranial nerve structural organization (GO:0021604)2.57795148
109DNA integration (GO:0015074)2.57738755
110seminiferous tubule development (GO:0072520)2.56411798
111protein K11-linked deubiquitination (GO:0035871)2.56272149
112negative regulation of stem cell proliferation (GO:2000647)2.56200495
113cellular ketone body metabolic process (GO:0046950)2.56032961
114urinary tract smooth muscle contraction (GO:0014848)2.55033658
115positive regulation of protein homodimerization activity (GO:0090073)2.54431254
116negative regulation of myoblast differentiation (GO:0045662)2.53151354
117adenosine metabolic process (GO:0046085)2.52656928
118generation of neurons (GO:0048699)2.52227666
119retrograde transport, vesicle recycling within Golgi (GO:0000301)2.51666370
120neuron recognition (GO:0008038)2.51541552
121regulation of hexokinase activity (GO:1903299)2.48657976
122regulation of glucokinase activity (GO:0033131)2.48657976
123regulation of rhodopsin mediated signaling pathway (GO:0022400)2.48312036
124spinal cord development (GO:0021510)2.48257463
125positive regulation of amino acid transport (GO:0051957)2.47799321
126regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.47357679
127water-soluble vitamin biosynthetic process (GO:0042364)2.47208072
128peristalsis (GO:0030432)2.47146857
129regulation of respiratory system process (GO:0044065)2.46278445
130synapse assembly (GO:0007416)2.44955625
131pyrimidine nucleobase catabolic process (GO:0006208)2.44941231
132kynurenine metabolic process (GO:0070189)2.43898669
133detection of mechanical stimulus involved in sensory perception (GO:0050974)2.43735533
134negative regulation of systemic arterial blood pressure (GO:0003085)2.43208357
135regulation of collateral sprouting (GO:0048670)2.43072957
136auditory behavior (GO:0031223)2.42825890
137photoreceptor cell development (GO:0042461)2.42769772
138GMP metabolic process (GO:0046037)2.41691565
139retina layer formation (GO:0010842)2.39937693
140proline transport (GO:0015824)2.39633322
141protein localization to microtubule (GO:0035372)2.39207095
142cAMP catabolic process (GO:0006198)2.39041314
143signal peptide processing (GO:0006465)2.38426506
144spinal cord motor neuron differentiation (GO:0021522)2.38274013
145inner ear receptor stereocilium organization (GO:0060122)2.37761839
146dendrite morphogenesis (GO:0048813)2.37205050
147phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.36931559
148regulation of male gonad development (GO:2000018)2.34200517
149dendrite development (GO:0016358)2.32181011
150vesicle docking involved in exocytosis (GO:0006904)2.31839443
151nonmotile primary cilium assembly (GO:0035058)2.31313648
152extracellular negative regulation of signal transduction (GO:1900116)2.30583867
153extracellular regulation of signal transduction (GO:1900115)2.30583867
154cellular response to gamma radiation (GO:0071480)2.30414703
155hindbrain development (GO:0030902)2.29518694
156positive regulation of mitochondrial fission (GO:0090141)2.29145770
157regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.27769902
158mechanosensory behavior (GO:0007638)2.26194919
159positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.26091131
160mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.26091131
161dopamine transport (GO:0015872)2.26045613
162ganglion development (GO:0061548)2.25307453
163positive regulation of synapse assembly (GO:0051965)2.25202023
164rhodopsin mediated signaling pathway (GO:0016056)2.25031613
165microtubule polymerization or depolymerization (GO:0031109)2.24591936
166G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.24356806
167peripheral nervous system neuron development (GO:0048935)2.22242935
168regulation of synapse assembly (GO:0051963)2.21875298
169base-excision repair, AP site formation (GO:0006285)2.21222699
170regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.20333096
171regulation of mitotic spindle checkpoint (GO:1903504)2.20333096
172deoxyribose phosphate biosynthetic process (GO:0046385)2.20329248
1732-deoxyribonucleotide biosynthetic process (GO:0009265)2.20329248
174superoxide anion generation (GO:0042554)2.19441432
175kidney morphogenesis (GO:0060993)2.18614542
176negative regulation of norepinephrine secretion (GO:0010700)2.18264686
177phosphorylated carbohydrate dephosphorylation (GO:0046838)2.17407868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.36268461
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04945954
3TAF15_26573619_Chip-Seq_HEK293_Human2.93271123
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.87107611
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.83782129
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.65987307
7ZNF274_21170338_ChIP-Seq_K562_Hela2.65977678
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60710018
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.59959316
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43353437
11EZH2_22144423_ChIP-Seq_EOC_Human2.40837388
12P300_19829295_ChIP-Seq_ESCs_Human2.21371755
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.20049188
14* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19274486
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.15891446
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.12157298
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02406492
18IGF1R_20145208_ChIP-Seq_DFB_Human1.99975942
19FUS_26573619_Chip-Seq_HEK293_Human1.95218142
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.91977408
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91881320
22* SMAD4_21799915_ChIP-Seq_A2780_Human1.80797079
23* NANOG_18555785_Chip-Seq_ESCs_Mouse1.76476977
24RNF2_27304074_Chip-Seq_NSC_Mouse1.72398334
25TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.72224481
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70926352
27* EWS_26573619_Chip-Seq_HEK293_Human1.69571025
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68158767
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68105076
30EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.65741882
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.64433335
32E2F1_18555785_Chip-Seq_ESCs_Mouse1.63811522
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62699101
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61410912
35* P53_22387025_ChIP-Seq_ESCs_Mouse1.60434773
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60240131
37CBP_20019798_ChIP-Seq_JUKART_Human1.59434067
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59434067
39SUZ12_18555785_Chip-Seq_ESCs_Mouse1.59108129
40NFE2_27457419_Chip-Seq_LIVER_Mouse1.58452720
41ER_23166858_ChIP-Seq_MCF-7_Human1.58278485
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.58106138
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57872164
44BCAT_22108803_ChIP-Seq_LS180_Human1.57849575
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55423188
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55100752
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54760399
48STAT3_18555785_Chip-Seq_ESCs_Mouse1.54707819
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53655054
50VDR_22108803_ChIP-Seq_LS180_Human1.53488950
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50961063
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50450608
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.47657528
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47608683
55CMYC_18555785_Chip-Seq_ESCs_Mouse1.47152951
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.46660476
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.46632312
58EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.46500955
59* P300_18555785_Chip-Seq_ESCs_Mouse1.45051046
60NMYC_18555785_Chip-Seq_ESCs_Mouse1.40101877
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39941146
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38125142
63RUNX1_27457419_Chip-Seq_LIVER_Mouse1.37779796
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37414706
65STAT3_23295773_ChIP-Seq_U87_Human1.37183111
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37140051
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37099862
68SOX2_18555785_Chip-Seq_ESCs_Mouse1.36809818
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36563493
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.35976250
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35510521
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35421120
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34023814
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32576648
75TCF4_23295773_ChIP-Seq_U87_Human1.31840156
76* TCF4_22108803_ChIP-Seq_LS180_Human1.31071165
77TAL1_26923725_Chip-Seq_HPCs_Mouse1.28467195
78OCT4_18555785_Chip-Seq_ESCs_Mouse1.28388178
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28372640
80* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28199367
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.28166385
82IRF1_19129219_ChIP-ChIP_H3396_Human1.27826383
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27609280
84AR_25329375_ChIP-Seq_VCAP_Human1.25911739
85KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25556591
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24654867
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.24409645
88KDM2B_26808549_Chip-Seq_REH_Human1.24172767
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.23424269
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22560255
91PU1_27457419_Chip-Seq_LIVER_Mouse1.21729169
92CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21451520
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20724150
94REST_21632747_ChIP-Seq_MESCs_Mouse1.20182441
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.19751689
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.17539596
97ZFX_18555785_Chip-Seq_ESCs_Mouse1.17239125
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17086889
99RUNX2_22187159_ChIP-Seq_PCA_Human1.16934214
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.15664296
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15352794
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14877830
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13410722
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13410722
105KLF4_18555785_Chip-Seq_ESCs_Mouse1.12997296
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.12311017
107SOX9_26525672_Chip-Seq_HEART_Mouse1.12253999
108SMAD1_18555785_Chip-Seq_ESCs_Mouse1.11551366
109KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10892341
110CTCF_18555785_Chip-Seq_ESCs_Mouse1.10122664
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10108721
112NANOG_19829295_ChIP-Seq_ESCs_Human1.09528363
113SOX2_19829295_ChIP-Seq_ESCs_Human1.09528363
114CRX_20693478_ChIP-Seq_RETINA_Mouse1.09060770
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08935884
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08626191
117AR_21572438_ChIP-Seq_LNCaP_Human1.08065731
118TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07520667
119AHR_22903824_ChIP-Seq_MCF-7_Human1.07273218
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07144528
121* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06582045
122TP53_18474530_ChIP-ChIP_U2OS_Human1.05725878
123RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05648667
124EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05648667
125SMAD4_21741376_ChIP-Seq_EPCs_Human1.05156119
126TP53_16413492_ChIP-PET_HCT116_Human1.04333245
127FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04324407
128JUN_21703547_ChIP-Seq_K562_Human1.03797213
129* TP53_22573176_ChIP-Seq_HFKS_Human1.03468760
130HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02285224
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01501829
132NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01501829
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01423198

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.30748480
2MP0005646_abnormal_pituitary_gland3.32258003
3MP0001986_abnormal_taste_sensitivity3.22387363
4MP0000015_abnormal_ear_pigmentation2.96297464
5MP0005645_abnormal_hypothalamus_physiol2.76186707
6MP0003880_abnormal_central_pattern2.72585367
7MP0003787_abnormal_imprinting2.66633743
8MP0006292_abnormal_olfactory_placode2.66571611
9MP0005171_absent_coat_pigmentation2.65742576
10MP0008877_abnormal_DNA_methylation2.47192037
11MP0005409_darkened_coat_color2.29820491
12MP0002009_preneoplasia2.27088877
13MP0002876_abnormal_thyroid_physiology2.12814573
14MP0009697_abnormal_copulation2.10923017
15MP0004147_increased_porphyrin_level2.07671190
16MP0003195_calcinosis2.07103505
17MP0006276_abnormal_autonomic_nervous2.05480834
18MP0003183_abnormal_peptide_metabolism2.03662196
19MP0002735_abnormal_chemical_nociception2.02925991
20MP0000566_synostosis2.02778407
21MP0001984_abnormal_olfaction2.02238286
22MP0006072_abnormal_retinal_apoptosis2.00507165
23MP0000372_irregular_coat_pigmentation1.90692546
24MP0002234_abnormal_pharynx_morphology1.84769278
25MP0008260_abnormal_autophagy1.81643424
26MP0000678_abnormal_parathyroid_gland1.75256520
27MP0003122_maternal_imprinting1.72190629
28MP0003890_abnormal_embryonic-extraembry1.71269513
29MP0004133_heterotaxia1.70625388
30MP0005075_abnormal_melanosome_morpholog1.69625684
31MP0010386_abnormal_urinary_bladder1.66930031
32MP0000427_abnormal_hair_cycle1.65357803
33MP0004782_abnormal_surfactant_physiolog1.60570230
34MP0002938_white_spotting1.54739590
35MP0008789_abnormal_olfactory_epithelium1.53145313
36MP0001968_abnormal_touch/_nociception1.51947757
37MP0002736_abnormal_nociception_after1.48312376
38MP0005394_taste/olfaction_phenotype1.47104177
39MP0005499_abnormal_olfactory_system1.47104177
40MP0002751_abnormal_autonomic_nervous1.45452947
41MP0001529_abnormal_vocalization1.44260207
42MP0002277_abnormal_respiratory_mucosa1.41912323
43MP0000778_abnormal_nervous_system1.41821554
44MP0001486_abnormal_startle_reflex1.40482394
45MP0000631_abnormal_neuroendocrine_gland1.37983106
46MP0003011_delayed_dark_adaptation1.37020722
47MP0003136_yellow_coat_color1.35865684
48MP0001177_atelectasis1.34389688
49MP0002572_abnormal_emotion/affect_behav1.34350567
50MP0002095_abnormal_skin_pigmentation1.33361587
51MP0002163_abnormal_gland_morphology1.32724402
52MP0003121_genomic_imprinting1.31656093
53MP0002067_abnormal_sensory_capabilities1.30188185
54MP0001501_abnormal_sleep_pattern1.29146751
55MP0000681_abnormal_thyroid_gland1.27487287
56MP0003943_abnormal_hepatobiliary_system1.26430154
57MP0002184_abnormal_innervation1.26038812
58MP0009745_abnormal_behavioral_response1.25714457
59MP0005423_abnormal_somatic_nervous1.25586813
60MP0000569_abnormal_digit_pigmentation1.24101502
61MP0001905_abnormal_dopamine_level1.23161182
62MP0002063_abnormal_learning/memory/cond1.22503676
63MP0008057_abnormal_DNA_replication1.21329832
64MP0004043_abnormal_pH_regulation1.21166299
65MP0002734_abnormal_mechanical_nocicepti1.19925059
66MP0009046_muscle_twitch1.19509049
67MP0004270_analgesia1.18713157
68MP0002557_abnormal_social/conspecific_i1.18550660
69MP0001919_abnormal_reproductive_system1.18192497
70MP0002272_abnormal_nervous_system1.18046584
71MP0004885_abnormal_endolymph1.18012983
72MP0001963_abnormal_hearing_physiology1.16326648
73MP0004742_abnormal_vestibular_system1.14416822
74MP0008058_abnormal_DNA_repair1.14210221
75MP0005551_abnormal_eye_electrophysiolog1.13535686
76MP0004134_abnormal_chest_morphology1.13422175
77MP0005174_abnormal_tail_pigmentation1.11552031
78MP0005195_abnormal_posterior_eye1.08496013
79MP0005379_endocrine/exocrine_gland_phen1.08418387
80MP0000026_abnormal_inner_ear1.07679870
81MP0002177_abnormal_outer_ear1.07645743
82MP0002638_abnormal_pupillary_reflex1.07544449
83MP0003635_abnormal_synaptic_transmissio1.07531793
84MP0000383_abnormal_hair_follicle1.06858233
85MP0003567_abnormal_fetal_cardiomyocyte1.05483680
86MP0002064_seizures1.05479090
87MP0000955_abnormal_spinal_cord1.05039398
88MP0003937_abnormal_limbs/digits/tail_de1.04266174
89MP0003941_abnormal_skin_development1.03903954
90MP0004215_abnormal_myocardial_fiber1.02701204
91MP0002837_dystrophic_cardiac_calcinosis1.02193928
92MP0005187_abnormal_penis_morphology0.98242507
93MP0002249_abnormal_larynx_morphology0.96594235
94MP0002233_abnormal_nose_morphology0.95843302
95MP0003119_abnormal_digestive_system0.95645816
96MP0002653_abnormal_ependyma_morphology0.95457683
97MP0000647_abnormal_sebaceous_gland0.95443518
98MP0008007_abnormal_cellular_replicative0.95182198
99MP0008961_abnormal_basal_metabolism0.94391735
100MP0002132_abnormal_respiratory_system0.94245055
101MP0004924_abnormal_behavior0.93376260
102MP0005386_behavior/neurological_phenoty0.93376260
103MP0001502_abnormal_circadian_rhythm0.93144901
104MP0001299_abnormal_eye_distance/0.91984726
105MP0002160_abnormal_reproductive_system0.91492524
106MP0005408_hypopigmentation0.91305367
107MP0005389_reproductive_system_phenotype0.89541331
108MP0001186_pigmentation_phenotype0.88528199
109MP0005391_vision/eye_phenotype0.88259133
110MP0008995_early_reproductive_senescence0.87786623
111MP0004085_abnormal_heartbeat0.87036610
112MP0005084_abnormal_gallbladder_morpholo0.85325068
113MP0001293_anophthalmia0.84880453
114MP0009250_abnormal_appendicular_skeleto0.84302339
115MP0001324_abnormal_eye_pigmentation0.84076871
116MP0003938_abnormal_ear_development0.83521890
117MP0002928_abnormal_bile_duct0.83451819
118MP0004142_abnormal_muscle_tone0.83089184
119MP0002102_abnormal_ear_morphology0.82750566
120MP0002229_neurodegeneration0.82285097
121MP0003283_abnormal_digestive_organ0.81720301
122MP0004145_abnormal_muscle_electrophysio0.81582559
123MP0004859_abnormal_synaptic_plasticity0.80605891
124MP0005253_abnormal_eye_physiology0.80523973
125MP0003942_abnormal_urinary_system0.79114294
126MP0000049_abnormal_middle_ear0.78988399
127MP0003698_abnormal_male_reproductive0.78210910
128MP0005367_renal/urinary_system_phenotyp0.77353388
129MP0000516_abnormal_urinary_system0.77353388
130MP0001485_abnormal_pinna_reflex0.76254279
131MP0003633_abnormal_nervous_system0.75691445
132MP0002882_abnormal_neuron_morphology0.75583086
133MP0004381_abnormal_hair_follicle0.75551980
134MP0003632_abnormal_nervous_system0.75207959
135MP0003252_abnormal_bile_duct0.74832879
136MP0002752_abnormal_somatic_nervous0.73507474
137MP0001970_abnormal_pain_threshold0.72259646
138MP0003755_abnormal_palate_morphology0.70943930
139MP0008569_lethality_at_weaning0.70074916

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)5.34060537
2Hypothermia (HP:0002045)4.25679114
3Febrile seizures (HP:0002373)3.74264774
4True hermaphroditism (HP:0010459)3.36132018
5Protruding tongue (HP:0010808)3.24191333
6Genetic anticipation (HP:0003743)3.07870636
7Abnormality of the renal cortex (HP:0011035)3.06816777
8Medial flaring of the eyebrow (HP:0010747)3.06746755
9Hyperventilation (HP:0002883)3.01538675
10Type I transferrin isoform profile (HP:0003642)3.00915646
11Nephrogenic diabetes insipidus (HP:0009806)2.93760697
12Abnormality of incisor morphology (HP:0011063)2.93567806
13Gait imbalance (HP:0002141)2.87507581
14Poor coordination (HP:0002370)2.80948461
15Congenital primary aphakia (HP:0007707)2.80308367
16Atonic seizures (HP:0010819)2.78756908
17Pancreatic fibrosis (HP:0100732)2.76601480
18Prostate neoplasm (HP:0100787)2.73812974
19Epileptic encephalopathy (HP:0200134)2.70149030
20Alveolar cell carcinoma (HP:0006519)2.68992186
21Patchy hypopigmentation of hair (HP:0011365)2.68510386
22Submucous cleft hard palate (HP:0000176)2.67262639
23Tubulointerstitial nephritis (HP:0001970)2.65886858
24White forelock (HP:0002211)2.65673882
25Fair hair (HP:0002286)2.63590780
26Focal motor seizures (HP:0011153)2.63277533
27Chronic hepatic failure (HP:0100626)2.63060986
28Drooling (HP:0002307)2.60599266
29Progressive sensorineural hearing impairment (HP:0000408)2.58977612
30Focal seizures (HP:0007359)2.57910430
31Congenital stationary night blindness (HP:0007642)2.56006352
32Renal cortical cysts (HP:0000803)2.52854614
33Cystic liver disease (HP:0006706)2.43945066
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.38438889
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38324194
36Tubular atrophy (HP:0000092)2.37034027
37Genital tract atresia (HP:0001827)2.36769321
38Lissencephaly (HP:0001339)2.36703579
39Generalized hypopigmentation of hair (HP:0011358)2.35810153
40Embryonal renal neoplasm (HP:0011794)2.33798440
41Abnormality of the nasal septum (HP:0000419)2.33674292
42Vaginal atresia (HP:0000148)2.32679777
43Abnormality of the prostate (HP:0008775)2.30961443
44Excessive salivation (HP:0003781)2.30711142
45Stomach cancer (HP:0012126)2.29533805
46Abnormality of macular pigmentation (HP:0008002)2.27689808
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27131375
48Abnormal protein N-linked glycosylation (HP:0012347)2.27131375
49Abnormal protein glycosylation (HP:0012346)2.27131375
50Abnormal glycosylation (HP:0012345)2.27131375
51Nephroblastoma (Wilms tumor) (HP:0002667)2.25810473
52Abnormality of the labia minora (HP:0012880)2.25762987
53Blue irides (HP:0000635)2.25284716
54Attenuation of retinal blood vessels (HP:0007843)2.24974006
55Neoplasm of the tracheobronchial system (HP:0100552)2.24833047
56Tubulointerstitial abnormality (HP:0001969)2.24474470
57Type II lissencephaly (HP:0007260)2.17429289
58Optic nerve hypoplasia (HP:0000609)2.17325204
59Bifid tongue (HP:0010297)2.16810340
60Methylmalonic acidemia (HP:0002912)2.15765734
61Supernumerary spleens (HP:0009799)2.15689945
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14230592
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.14230592
64Dialeptic seizures (HP:0011146)2.12705003
65Cerebellar dysplasia (HP:0007033)2.12192321
66Congenital hepatic fibrosis (HP:0002612)2.10733295
67Abolished electroretinogram (ERG) (HP:0000550)2.10578331
68Short foot (HP:0001773)2.09176352
69Abnormality of the pubic bones (HP:0003172)2.05933953
70Broad foot (HP:0001769)2.05475204
71Aplasia/Hypoplasia of the lens (HP:0008063)2.05037051
72Inability to walk (HP:0002540)2.03811509
73Increased corneal curvature (HP:0100692)2.03279285
74Keratoconus (HP:0000563)2.03279285
75Abnormality of the columella (HP:0009929)2.02201782
76Postaxial foot polydactyly (HP:0001830)2.01581320
77Aplasia/Hypoplasia of the fovea (HP:0008060)2.00428707
78Hypoplasia of the fovea (HP:0007750)2.00428707
79Progressive inability to walk (HP:0002505)1.98881255
80Thyroiditis (HP:0100646)1.98740428
81Chromsome breakage (HP:0040012)1.98562420
82Preaxial hand polydactyly (HP:0001177)1.98294816
83Absent eyebrow (HP:0002223)1.97514722
84Decreased testicular size (HP:0008734)1.96707047
85Narrow forehead (HP:0000341)1.96567186
86Pancreatic cysts (HP:0001737)1.96382679
87Sleep apnea (HP:0010535)1.96266867
88Hyperglycinemia (HP:0002154)1.94882577
89Nephronophthisis (HP:0000090)1.94697241
90Molar tooth sign on MRI (HP:0002419)1.94242290
91Abnormality of midbrain morphology (HP:0002418)1.94242290
92Abnormality of hair growth rate (HP:0011363)1.93973256
93Slow-growing hair (HP:0002217)1.93973256
94Prominent nasal bridge (HP:0000426)1.93430303
95Heterochromia iridis (HP:0001100)1.91322838
96Pachygyria (HP:0001302)1.91024123
97Absent speech (HP:0001344)1.90828377
98Hepatoblastoma (HP:0002884)1.90111600
99Colon cancer (HP:0003003)1.89284365
100Aplasia/Hypoplasia of the tibia (HP:0005772)1.89270803
101Abnormality of the right ventricle (HP:0001707)1.88725283
102Abnormality of the fovea (HP:0000493)1.88570664
103Papillary thyroid carcinoma (HP:0002895)1.87962644
104Specific learning disability (HP:0001328)1.86550039
105Abnormal drinking behavior (HP:0030082)1.86455446
106Polydipsia (HP:0001959)1.86455446
107Abnormal biliary tract physiology (HP:0012439)1.84994257
108Bile duct proliferation (HP:0001408)1.84994257
109Chorioretinal coloboma (HP:0000567)1.84936969
110Oligodactyly (hands) (HP:0001180)1.83771219
111Bony spicule pigmentary retinopathy (HP:0007737)1.82606850
112Sclerocornea (HP:0000647)1.82595466
113Curly hair (HP:0002212)1.82551245
114Gaze-evoked nystagmus (HP:0000640)1.81675924
115Abnormality of male internal genitalia (HP:0000022)1.80837830
116Occipital encephalocele (HP:0002085)1.80738492
117Progressive cerebellar ataxia (HP:0002073)1.80603599
118Short tibia (HP:0005736)1.79828865
119Abnormality of the corticospinal tract (HP:0002492)1.79477774
120Disproportionate short-trunk short stature (HP:0003521)1.79005659
121Anencephaly (HP:0002323)1.77773663
122Hypoplastic left heart (HP:0004383)1.75362734
123Hip dysplasia (HP:0001385)1.74986016
124Absence seizures (HP:0002121)1.74882846
125Intestinal atresia (HP:0011100)1.74748187
126Septo-optic dysplasia (HP:0100842)1.74503247
127Osteomalacia (HP:0002749)1.74210795
128Xerostomia (HP:0000217)1.72479375
129Abnormal lung lobation (HP:0002101)1.72310548
130Thyroid carcinoma (HP:0002890)1.71790742
131Limb dystonia (HP:0002451)1.71293168
132Tracheomalacia (HP:0002779)1.70278681
133Fetal akinesia sequence (HP:0001989)1.69903647
134Hypoplastic iliac wings (HP:0002866)1.69539419
135Male pseudohermaphroditism (HP:0000037)1.69024531
136Micropenis (HP:0000054)1.68719927
137Abnormality of the nasolacrimal system (HP:0000614)1.67447727
138Postaxial hand polydactyly (HP:0001162)1.67373607
139Lip pit (HP:0100267)1.67176228
140Optic nerve coloboma (HP:0000588)1.67103549
141Cutaneous finger syndactyly (HP:0010554)1.66774122
142Chorioretinal atrophy (HP:0000533)1.66652617
143Epidermoid cyst (HP:0200040)1.66376745
144Broad-based gait (HP:0002136)1.66280744
145Asymmetry of the thorax (HP:0001555)1.65733344
146Abnormality of the renal medulla (HP:0100957)1.65651110
147Cupped ear (HP:0000378)1.64405913
148Aganglionic megacolon (HP:0002251)1.62484501
149Decreased circulating renin level (HP:0003351)1.62420867
150Flared iliac wings (HP:0002869)1.61660083
151Progressive hearing impairment (HP:0001730)1.61110862
152Deep philtrum (HP:0002002)1.59854792
153Abnormal rod and cone electroretinograms (HP:0008323)1.58138198
154Astigmatism (HP:0000483)1.58075574
155Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.56811237
156Widely spaced teeth (HP:0000687)1.56456081
157Clubbing of toes (HP:0100760)1.56359346
158Thyroid-stimulating hormone excess (HP:0002925)1.56007403
159Gastroesophageal reflux (HP:0002020)1.55604445
160Palpebral edema (HP:0100540)1.55540401
161Abnormality of the incisor (HP:0000676)1.54687124

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.55495926
2AKT33.57073424
3PRPF4B3.13770289
4MAP4K22.99737882
5SGK22.80810023
6BMPR1B2.74442972
7SIK32.29043989
8YES12.21114903
9MKNK22.15189989
10MAP2K72.12063725
11BMPR22.12027604
12SGK4942.01357821
13SGK2232.01357821
14ERBB31.99502869
15ZAK1.99049649
16MAPK131.93260321
17MKNK11.86136242
18SGK31.80208151
19MAP3K141.74648619
20CCNB11.62004938
21TXK1.58269314
22STK161.50495148
23TNIK1.49997554
24MAP3K121.46263237
25TAOK31.44971225
26PAK31.41802275
27ACVR1B1.36284519
28PLK21.34578790
29TRIM281.33068476
30SRPK11.29394791
31IRAK41.26251759
32INSRR1.24934143
33EIF2AK21.14171964
34CDK81.13536612
35STK391.11147299
36FGFR21.09789899
37NUAK11.09067845
38MARK11.08813530
39CSNK1G21.07411304
40NTRK21.06881655
41BCR1.03944748
42VRK11.01350021
43CAMKK20.99325703
44CSNK1G10.97978515
45CDK30.97883602
46ADRBK20.96861221
47WNK40.96337603
48PLK30.95365841
49TEC0.94206672
50BRAF0.93931129
51MUSK0.92504124
52IRAK30.90113083
53CSNK1A1L0.89238216
54EPHA40.89027599
55PNCK0.89002438
56CDK190.88175964
57MAP2K40.87116747
58TAOK20.86856894
59NEK60.86130243
60CSNK1G30.83644797
61FER0.81747005
62RPS6KA20.80652860
63RPS6KB10.79228240
64TNK20.77324806
65OXSR10.76402720
66TRPM70.74998122
67NTRK30.74518546
68NEK90.74308683
69WNK30.72884380
70DYRK20.71546395
71DYRK30.70576822
72FRK0.69922674
73GRK70.69145931
74IRAK20.68085946
75CLK10.67007605
76OBSCN0.66649861
77STK240.66489181
78PDK20.65505746
79FLT30.65211468
80RPS6KC10.65159149
81RPS6KL10.65159149
82PRKCE0.64388142
83PKN10.63929629
84MAP3K40.63594838
85PIK3CG0.63504819
86DAPK10.62478491
87STK38L0.62048398
88RPS6KA60.58714525
89CAMK1G0.56776528
90PLK40.55509797
91EPHA30.54170046
92TGFBR10.53074470
93BCKDK0.53008724
94SGK10.52727118
95TIE10.51789578
96MYLK0.51552766
97UHMK10.50444155
98GRK10.49282541
99PINK10.48495025
100TAF10.48117458
101PTK2B0.46163001
102CSNK1D0.46091248
103IRAK10.45795784
104TSSK60.45192817
105CHUK0.45041539
106BRSK20.44894472
107ERBB20.44637476
108CDK50.43696155
109IKBKE0.43285954
110MINK10.42880566
111CAMK10.42518502
112STK110.40370200
113PRKACB0.40242081
114PHKG10.40013619
115PHKG20.40013619
116DAPK20.39974436
117CAMK2A0.39904687
118CAMK2B0.39389755
119PRKAA10.39157037
120PIK3CA0.38128305
121FGFR10.37888713
122PRKCG0.37286085
123BRD40.36558577
124PRKCH0.35323749
125CSNK1A10.35267964
126MAP3K70.33892572
127DYRK1A0.32950527
128LATS10.32723289
129MAPKAPK50.31821379
130IGF1R0.31374355
131DYRK1B0.30905438
132CAMK40.30647908
133MAPK70.28914874
134IKBKB0.28256191
135NLK0.28111342
136KIT0.26146382
137ITK0.25650363
138PRKG10.25154503
139PRKCQ0.25112434
140PRKACA0.24498398
141CAMK2D0.23454055
142ADRBK10.23118047
143BUB10.22579108

Predicted pathways (KEGG)

RankGene SetZ-score
1Butanoate metabolism_Homo sapiens_hsa006502.64906066
2Phototransduction_Homo sapiens_hsa047442.52356248
3Nicotine addiction_Homo sapiens_hsa050332.38368234
4Protein export_Homo sapiens_hsa030602.35982145
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.28288402
6Propanoate metabolism_Homo sapiens_hsa006402.15712920
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11404758
8Serotonergic synapse_Homo sapiens_hsa047262.05833234
9SNARE interactions in vesicular transport_Homo sapiens_hsa041302.03887150
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.02665807
11Taste transduction_Homo sapiens_hsa047421.99700496
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.97440159
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87909442
14Basal transcription factors_Homo sapiens_hsa030221.87172659
15Base excision repair_Homo sapiens_hsa034101.86530498
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82938184
17Olfactory transduction_Homo sapiens_hsa047401.81616606
18Linoleic acid metabolism_Homo sapiens_hsa005911.79217463
19Collecting duct acid secretion_Homo sapiens_hsa049661.76527233
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73588154
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73586504
22Morphine addiction_Homo sapiens_hsa050321.71903657
23Synaptic vesicle cycle_Homo sapiens_hsa047211.67852443
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64019208
25Vibrio cholerae infection_Homo sapiens_hsa051101.63522738
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60247141
27Fanconi anemia pathway_Homo sapiens_hsa034601.56457654
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.53539200
29ABC transporters_Homo sapiens_hsa020101.50154482
30Regulation of autophagy_Homo sapiens_hsa041401.48859432
31Circadian entrainment_Homo sapiens_hsa047131.43087723
32Nitrogen metabolism_Homo sapiens_hsa009101.40939909
33Rheumatoid arthritis_Homo sapiens_hsa053231.37926722
34Tryptophan metabolism_Homo sapiens_hsa003801.36789982
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.30450491
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28191620
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.26130075
38Peroxisome_Homo sapiens_hsa041461.25857651
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22662874
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21024171
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20833719
42Ether lipid metabolism_Homo sapiens_hsa005651.20053319
43GABAergic synapse_Homo sapiens_hsa047271.19010980
44Glutamatergic synapse_Homo sapiens_hsa047241.16568242
45Arachidonic acid metabolism_Homo sapiens_hsa005901.15940218
46Homologous recombination_Homo sapiens_hsa034401.15597919
47Axon guidance_Homo sapiens_hsa043601.12866331
48Non-homologous end-joining_Homo sapiens_hsa034501.10693816
49Phagosome_Homo sapiens_hsa041451.10081125
50Retinol metabolism_Homo sapiens_hsa008301.09007066
51Autoimmune thyroid disease_Homo sapiens_hsa053201.08414133
52Dopaminergic synapse_Homo sapiens_hsa047281.07291586
53Fatty acid metabolism_Homo sapiens_hsa012121.05745858
54Insulin secretion_Homo sapiens_hsa049111.03395933
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02206257
56Nucleotide excision repair_Homo sapiens_hsa034201.00948058
57Selenocompound metabolism_Homo sapiens_hsa004501.00928878
58Hedgehog signaling pathway_Homo sapiens_hsa043400.99763372
59Steroid biosynthesis_Homo sapiens_hsa001000.96916868
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94862192
61Amphetamine addiction_Homo sapiens_hsa050310.94629333
62RNA polymerase_Homo sapiens_hsa030200.92703691
63Cholinergic synapse_Homo sapiens_hsa047250.92374660
64RNA degradation_Homo sapiens_hsa030180.91577574
65Caffeine metabolism_Homo sapiens_hsa002320.91127373
66Salivary secretion_Homo sapiens_hsa049700.90957644
67Chemical carcinogenesis_Homo sapiens_hsa052040.88748825
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88317027
69beta-Alanine metabolism_Homo sapiens_hsa004100.87966222
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87193717
71Long-term depression_Homo sapiens_hsa047300.85512867
72Graft-versus-host disease_Homo sapiens_hsa053320.85346132
73Fatty acid elongation_Homo sapiens_hsa000620.84503358
74Fatty acid degradation_Homo sapiens_hsa000710.82510202
75Fatty acid biosynthesis_Homo sapiens_hsa000610.81946612
76N-Glycan biosynthesis_Homo sapiens_hsa005100.81847231
77Allograft rejection_Homo sapiens_hsa053300.81828278
78Melanoma_Homo sapiens_hsa052180.81471520
79Measles_Homo sapiens_hsa051620.80832229
80Glycerolipid metabolism_Homo sapiens_hsa005610.80470090
81Sphingolipid metabolism_Homo sapiens_hsa006000.80058156
82Purine metabolism_Homo sapiens_hsa002300.78989045
83Endometrial cancer_Homo sapiens_hsa052130.77794056
84Dorso-ventral axis formation_Homo sapiens_hsa043200.77281139
85Histidine metabolism_Homo sapiens_hsa003400.75400141
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.75099084
87Long-term potentiation_Homo sapiens_hsa047200.73809958
88Basal cell carcinoma_Homo sapiens_hsa052170.71925970
89Type I diabetes mellitus_Homo sapiens_hsa049400.70137128
90Sulfur metabolism_Homo sapiens_hsa009200.70007189
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69709639
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69197491
93ErbB signaling pathway_Homo sapiens_hsa040120.69181845
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.68711562
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67221757
96Vitamin B6 metabolism_Homo sapiens_hsa007500.67022808
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.66970918
98Fat digestion and absorption_Homo sapiens_hsa049750.66799655
99Calcium signaling pathway_Homo sapiens_hsa040200.63587946
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.63488891
101Circadian rhythm_Homo sapiens_hsa047100.62743272
102Mismatch repair_Homo sapiens_hsa034300.62655072
103Prostate cancer_Homo sapiens_hsa052150.62168741
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61078369
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59232746
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58850648
107Cocaine addiction_Homo sapiens_hsa050300.58604478
108Lysine degradation_Homo sapiens_hsa003100.58257138
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58208943
110Cell cycle_Homo sapiens_hsa041100.56301987
111Renin secretion_Homo sapiens_hsa049240.54430609
112TGF-beta signaling pathway_Homo sapiens_hsa043500.53841296
113Parkinsons disease_Homo sapiens_hsa050120.53117319
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52744632
115cAMP signaling pathway_Homo sapiens_hsa040240.52454206
116Ras signaling pathway_Homo sapiens_hsa040140.52251828
117Cardiac muscle contraction_Homo sapiens_hsa042600.51890352
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51558675
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51549054
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51088095
121Thyroid cancer_Homo sapiens_hsa052160.48745736
122Oxytocin signaling pathway_Homo sapiens_hsa049210.48374704
123Gastric acid secretion_Homo sapiens_hsa049710.47839313
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47793635
125Alcoholism_Homo sapiens_hsa050340.47355060
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46787483
127Influenza A_Homo sapiens_hsa051640.46292359
128Colorectal cancer_Homo sapiens_hsa052100.46285230
129Huntingtons disease_Homo sapiens_hsa050160.46152814
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46118997
131Oxidative phosphorylation_Homo sapiens_hsa001900.45678284
132Chemokine signaling pathway_Homo sapiens_hsa040620.45014233
133Wnt signaling pathway_Homo sapiens_hsa043100.44902191
134Metabolic pathways_Homo sapiens_hsa011000.43036913
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42619808
136Hematopoietic cell lineage_Homo sapiens_hsa046400.42386536
137MAPK signaling pathway_Homo sapiens_hsa040100.41841189
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41834149
139Asthma_Homo sapiens_hsa053100.41265111
140Primary immunodeficiency_Homo sapiens_hsa053400.40746724
141Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40359464
142Ovarian steroidogenesis_Homo sapiens_hsa049130.39924369
143Inositol phosphate metabolism_Homo sapiens_hsa005620.39493021
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.38826040
145Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37976679
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37653870
147Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37396863
148Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37212245
149Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36266587
150Pancreatic secretion_Homo sapiens_hsa049720.35504404
151FoxO signaling pathway_Homo sapiens_hsa040680.35215987

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