TBL1XR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)6.91942325
2doxorubicin metabolic process (GO:0044598)6.91942325
3daunorubicin metabolic process (GO:0044597)6.91942325
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.36181342
5negative regulation of cell killing (GO:0031342)6.36181342
6mitotic sister chromatid cohesion (GO:0007064)5.17391253
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03192094
8DNA double-strand break processing (GO:0000729)4.81691961
9regulation of B cell receptor signaling pathway (GO:0050855)4.51291079
10cytoplasmic mRNA processing body assembly (GO:0033962)4.46036626
11positive regulation of gamma-delta T cell activation (GO:0046645)4.32078358
12negative regulation of DNA-dependent DNA replication (GO:2000104)4.08758354
13aminoglycoside antibiotic metabolic process (GO:0030647)3.98290784
14resolution of meiotic recombination intermediates (GO:0000712)3.77524801
15limb bud formation (GO:0060174)3.71932289
16protein K6-linked ubiquitination (GO:0085020)3.65243695
17regulation of DNA endoreduplication (GO:0032875)3.64944176
18interferon-gamma production (GO:0032609)3.64843365
19positive regulation of protein autophosphorylation (GO:0031954)3.58212012
20maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.57350024
21response to pheromone (GO:0019236)3.56753772
22nuclear pore complex assembly (GO:0051292)3.42982789
23kinetochore assembly (GO:0051382)3.41324053
24synapsis (GO:0007129)3.40969698
25chromatin remodeling at centromere (GO:0031055)3.40769294
26keratinocyte development (GO:0003334)3.40507541
27histone exchange (GO:0043486)3.39440375
28positive T cell selection (GO:0043368)3.39247120
29B cell receptor signaling pathway (GO:0050853)3.38589874
30negative regulation of phagocytosis (GO:0050765)3.36329699
31positive thymic T cell selection (GO:0045059)3.36276993
32CENP-A containing nucleosome assembly (GO:0034080)3.35133950
33negative regulation of B cell proliferation (GO:0030889)3.33658067
34DNA replication-dependent nucleosome organization (GO:0034723)3.28366362
35DNA replication-dependent nucleosome assembly (GO:0006335)3.28366362
36negative T cell selection (GO:0043383)3.27105837
37lactate metabolic process (GO:0006089)3.26927551
38RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.26207332
39positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.24075519
40DNA strand renaturation (GO:0000733)3.23950061
41proteasome assembly (GO:0043248)3.15452101
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.15285798
43hepatocyte apoptotic process (GO:0097284)3.13319861
44histone H2A acetylation (GO:0043968)3.10810274
45negative regulation of T cell mediated immunity (GO:0002710)3.09763554
46double-strand break repair via homologous recombination (GO:0000724)3.08092706
47negative thymic T cell selection (GO:0045060)3.06034918
48recombinational repair (GO:0000725)3.05488239
49regulation of mesoderm development (GO:2000380)3.02840840
50regulation of nuclear cell cycle DNA replication (GO:0033262)3.01311309
51prenylation (GO:0097354)3.00897818
52protein prenylation (GO:0018342)3.00897818
53female gonad development (GO:0008585)3.00702247
54pore complex assembly (GO:0046931)2.98934568
55regulation of B cell differentiation (GO:0045577)2.98021904
56positive regulation of granulocyte differentiation (GO:0030854)2.96823228
57B cell homeostasis (GO:0001782)2.95062544
58positive regulation of glycoprotein biosynthetic process (GO:0010560)2.94660769
59histone H3-K4 trimethylation (GO:0080182)2.93139565
60definitive hemopoiesis (GO:0060216)2.93068295
61somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.92673711
62isotype switching (GO:0045190)2.92673711
63somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.92673711
64cellular extravasation (GO:0045123)2.91743776
65histone mRNA catabolic process (GO:0071044)2.89522137
66germinal center formation (GO:0002467)2.88713914
67platelet dense granule organization (GO:0060155)2.87698211
68UDP-N-acetylglucosamine metabolic process (GO:0006047)2.87253058
69regulation of gamma-delta T cell differentiation (GO:0045586)2.86512309
70cullin deneddylation (GO:0010388)2.86178843
71nuclear pore organization (GO:0006999)2.84889724
72response to X-ray (GO:0010165)2.84657544
73spindle checkpoint (GO:0031577)2.84448510
74regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.84350791
75dorsal/ventral axis specification (GO:0009950)2.82842007
76B cell proliferation (GO:0042100)2.82557472
77negative regulation of axon extension involved in axon guidance (GO:0048843)2.80703175
78response to interleukin-15 (GO:0070672)2.78093132
79DNA replication checkpoint (GO:0000076)2.77275348
80regulation of centriole replication (GO:0046599)2.76937179
81leukocyte aggregation (GO:0070486)2.76567918
82regulation of gamma-delta T cell activation (GO:0046643)2.75148899
83metaphase plate congression (GO:0051310)2.73533036
84DNA catabolic process, exonucleolytic (GO:0000738)2.73358070
85regulation of histone H3-K27 methylation (GO:0061085)2.72892964
86negative regulation of translation, ncRNA-mediated (GO:0040033)2.72301184
87regulation of translation, ncRNA-mediated (GO:0045974)2.72301184
88negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72301184
89negative regulation of JUN kinase activity (GO:0043508)2.71445517
90T cell migration (GO:0072678)2.71226031
91negative regulation of DNA recombination (GO:0045910)2.70031379
92regulation of telomere maintenance (GO:0032204)2.69532885
93regulation of meiosis I (GO:0060631)2.68682247
94kidney morphogenesis (GO:0060993)2.68669243
95non-recombinational repair (GO:0000726)2.68627415
96double-strand break repair via nonhomologous end joining (GO:0006303)2.68627415
97presynaptic membrane assembly (GO:0097105)2.68003394
98antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.67992404
99antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.67992404
100somite rostral/caudal axis specification (GO:0032525)2.67787534
101negative regulation of axon guidance (GO:1902668)2.67543620
102anterior/posterior axis specification, embryo (GO:0008595)2.67514531
103regulation of Rac protein signal transduction (GO:0035020)2.66930125
104protein K11-linked deubiquitination (GO:0035871)2.66182322
105regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.65965034
106regulation of mitotic spindle checkpoint (GO:1903504)2.65965034
107regulation of RNA export from nucleus (GO:0046831)2.65610410
108sister chromatid segregation (GO:0000819)2.63351748
109antigen processing and presentation of endogenous antigen (GO:0019883)2.63062102
110mitotic spindle checkpoint (GO:0071174)2.62936267
111negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.60768699
112T cell selection (GO:0045058)2.60164304
113attachment of spindle microtubules to kinetochore (GO:0008608)2.59455637
114centriole replication (GO:0007099)2.58275673
115cellular response to interleukin-15 (GO:0071350)2.58101949
116sister chromatid cohesion (GO:0007062)2.57793380
117regulation of glucokinase activity (GO:0033131)2.57666642
118regulation of hexokinase activity (GO:1903299)2.57666642
119DNA replication-independent nucleosome assembly (GO:0006336)2.57162127
120DNA replication-independent nucleosome organization (GO:0034724)2.57162127
121regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.56867888
122intraciliary transport (GO:0042073)2.56749699
123genitalia morphogenesis (GO:0035112)2.55689316
124mesenchymal cell differentiation involved in kidney development (GO:0072161)2.55447945
125mesenchymal cell differentiation involved in renal system development (GO:2001012)2.55447945
126regulation of alpha-beta T cell proliferation (GO:0046640)2.55376984
127regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.53390843
128monoubiquitinated protein deubiquitination (GO:0035520)2.52980475
129telomere maintenance via telomerase (GO:0007004)2.50546331
130replication fork processing (GO:0031297)2.49998310
131L-fucose metabolic process (GO:0042354)2.49780424
132L-fucose catabolic process (GO:0042355)2.49780424
133fucose catabolic process (GO:0019317)2.49780424
134positive regulation of B cell differentiation (GO:0045579)2.49723387
135thymic T cell selection (GO:0045061)2.48943196
136regulation of granulocyte differentiation (GO:0030852)2.48622394
137DNA ligation (GO:0006266)2.48345969
138centrosome organization (GO:0051297)2.47887490
139regulation of histone H3-K9 methylation (GO:0051570)2.47882913
140regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.47132099
141negative regulation of histone methylation (GO:0031061)2.45984095
142regulation of acyl-CoA biosynthetic process (GO:0050812)2.45981633
143exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45901512
144regulation of keratinocyte proliferation (GO:0010837)2.45684681
145negative regulation of granulocyte differentiation (GO:0030853)2.45640815
146protein deneddylation (GO:0000338)2.45242843
147kinetochore organization (GO:0051383)2.45027500
148branched-chain amino acid catabolic process (GO:0009083)2.44916313
149double-strand break repair (GO:0006302)2.44908419
150detection of molecule of bacterial origin (GO:0032490)2.44582976
151positive regulation of mitotic sister chromatid separation (GO:1901970)2.44403797
152positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.44403797
153positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.44403797
154regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.43960743
155histone mRNA metabolic process (GO:0008334)2.43476914
156regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.42997806
157lymphocyte homeostasis (GO:0002260)2.42751953
158water-soluble vitamin biosynthetic process (GO:0042364)2.42613047
159mitotic G2/M transition checkpoint (GO:0044818)2.42584121
160regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.42468314
161regulation of mitotic metaphase/anaphase transition (GO:0030071)2.42468314
162regulation of B cell proliferation (GO:0030888)2.42425038
163mast cell activation (GO:0045576)2.39039566
164regulation of T cell receptor signaling pathway (GO:0050856)2.36669182
165neural tube formation (GO:0001841)2.36339363
166positive regulation of DNA-dependent DNA replication (GO:2000105)2.35555094
167peptidyl-lysine trimethylation (GO:0018023)2.34245115
168T cell homeostasis (GO:0043029)2.33507856
169pre-miRNA processing (GO:0031054)2.31811220
170regulation of germinal center formation (GO:0002634)2.30346502
171regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.28605377
172tolerance induction (GO:0002507)2.28093691
173T-helper cell differentiation (GO:0042093)2.27964117
174CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.27964117
175regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.26948879
176positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.26948879
177positive regulation of alpha-beta T cell proliferation (GO:0046641)2.26804432
178dendritic cell migration (GO:0036336)2.26396621
179regulation of nucleobase-containing compound transport (GO:0032239)2.25170662
180antigen receptor-mediated signaling pathway (GO:0050851)2.24997245
181positive regulation of erythrocyte differentiation (GO:0045648)2.24469496
182mast cell activation involved in immune response (GO:0002279)2.24203426
183mast cell degranulation (GO:0043303)2.24203426
184regulation of sister chromatid cohesion (GO:0007063)2.24094258
185activated T cell proliferation (GO:0050798)2.23650286
186embryonic hemopoiesis (GO:0035162)2.23221242
187mature B cell differentiation (GO:0002335)2.23145762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.90570871
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.68898271
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.93029275
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.91887651
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.51475339
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.91245215
7* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.68793500
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.64547771
9GBX2_23144817_ChIP-Seq_PC3_Human2.62767206
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61519470
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.55738490
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.54838296
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.45892938
14ZNF274_21170338_ChIP-Seq_K562_Hela2.45317987
15VDR_22108803_ChIP-Seq_LS180_Human2.43673656
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.42561367
17TAF15_26573619_Chip-Seq_HEK293_Human2.40077073
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.37894527
19RUNX_20019798_ChIP-Seq_JUKART_Human2.34044329
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.30283608
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30118390
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.28323012
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.27894601
24RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21210225
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.20990367
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15306422
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15262781
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14853485
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.14538744
30* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.14044275
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12724030
32IGF1R_20145208_ChIP-Seq_DFB_Human2.11051905
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09328358
34SCL_19346495_ChIP-Seq_HPC-7_Human2.03708937
35MYB_21317192_ChIP-Seq_ERMYB_Mouse2.00816595
36ELK1_19687146_ChIP-ChIP_HELA_Human1.99434163
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91547179
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89598426
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88349276
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.83557823
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78833662
42TP53_16413492_ChIP-PET_HCT116_Human1.76381784
43* MYB_26560356_Chip-Seq_TH2_Human1.75761670
44* PIAS1_25552417_ChIP-Seq_VCAP_Human1.73683674
45* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71741857
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.70214545
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.69517752
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69006537
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.65205370
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.62548723
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.61900229
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61400192
53* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60109001
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.58507426
55* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55670844
56* ER_23166858_ChIP-Seq_MCF-7_Human1.55335291
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53660526
58* BCAT_22108803_ChIP-Seq_LS180_Human1.50607307
59* MYB_26560356_Chip-Seq_TH1_Human1.49864118
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45472376
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.44773038
62* MYC_22102868_ChIP-Seq_BL_Human1.42782601
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.42651003
64* EWS_26573619_Chip-Seq_HEK293_Human1.42306372
65AR_21572438_ChIP-Seq_LNCaP_Human1.40606615
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40316828
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38887269
68CBP_20019798_ChIP-Seq_JUKART_Human1.38887269
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38175215
70* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37892078
71* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37554100
72* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37017584
73SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36563731
74* AR_25329375_ChIP-Seq_VCAP_Human1.36518498
75TCF4_22108803_ChIP-Seq_LS180_Human1.35828536
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35602979
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34639007
78* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34098993
79* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31191533
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31159312
81AR_21909140_ChIP-Seq_LNCAP_Human1.27329134
82FUS_26573619_Chip-Seq_HEK293_Human1.26670937
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.26670015
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26432859
85VDR_24763502_ChIP-Seq_THP-1_Human1.25197489
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24549832
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24114944
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23968623
89SPI1_23547873_ChIP-Seq_NB4_Human1.23908687
90NANOG_19829295_ChIP-Seq_ESCs_Human1.23444276
91SOX2_19829295_ChIP-Seq_ESCs_Human1.23444276
92* TCF4_23295773_ChIP-Seq_U87_Human1.22702354
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22569714
94PU_27001747_Chip-Seq_BMDM_Mouse1.22249333
95* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22129025
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21957546
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21316050
98CDX2_22108803_ChIP-Seq_LS180_Human1.19574016
99* VDR_24787735_ChIP-Seq_THP-1_Human1.19564934
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.18737637
101* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18099460
102* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18099460
103* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17274856
104* TCF7_22412390_ChIP-Seq_EML_Mouse1.16936783
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.15538270
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14332411
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.13289867
108* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13193617
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12643866
110* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11973295
111NOTCH1_21737748_ChIP-Seq_TLL_Human1.11724485
112* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11236503
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11082188
114P300_18555785_Chip-Seq_ESCs_Mouse1.11056911
115RUNX2_22187159_ChIP-Seq_PCA_Human1.10848429
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10618735
117* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10473780
118* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10473780
119RXR_22108803_ChIP-Seq_LS180_Human1.09600804
120WT1_19549856_ChIP-ChIP_CCG9911_Human1.09126856
121PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08698466
122VDR_21846776_ChIP-Seq_THP-1_Human1.08547154
123OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08044503
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.08027024
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07800931
126* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07227430
127* NANOG_18555785_Chip-Seq_ESCs_Mouse1.06175397
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06153184
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05978069
130* RUNX1_22412390_ChIP-Seq_EML_Mouse1.05482493
131MAF_26560356_Chip-Seq_TH1_Human1.05172698
132STAT3_18555785_Chip-Seq_ESCs_Mouse1.03987367
133NFE2_27457419_Chip-Seq_LIVER_Mouse1.03030573
134* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01666348
135MYC_18940864_ChIP-ChIP_HL60_Human1.01636862
136SOX2_18555785_Chip-Seq_ESCs_Mouse1.01296822
137EZH2_27294783_Chip-Seq_NPCs_Mouse1.01199006
138EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01116695
139SMAD3_21741376_ChIP-Seq_HESCs_Human1.00976122
140* UTX_26944678_Chip-Seq_JUKART_Human1.00959626
141GATA1_22025678_ChIP-Seq_K562_Human0.98653624
142GATA3_27048872_Chip-Seq_THYMUS_Human0.96111160
143* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96041769
144* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95266912
145SPI1_23127762_ChIP-Seq_K562_Human0.95138602
146* P300_19829295_ChIP-Seq_ESCs_Human0.94990526
147* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93482459
148* P53_22387025_ChIP-Seq_ESCs_Mouse0.93274282
149* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93169248
150BRD4_25478319_ChIP-Seq_HGPS_Human0.92503337
151* CMYC_18555785_Chip-Seq_ESCs_Mouse0.92386176
152TCF4_18268006_ChIP-ChIP_LS174T_Human0.92109894
153KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90639200
154* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89015909
155* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88619980
156TP53_18474530_ChIP-ChIP_U2OS_Human0.86795328
157* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86591150
158OCT4_18555785_Chip-Seq_ESCs_Mouse0.85872777
159STAT3_23295773_ChIP-Seq_U87_Human0.85385621
160SMRT_27268052_Chip-Seq_Bcells_Human0.84319799
161CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83656958
162* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.83172956

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.78783560
2MP0002396_abnormal_hematopoietic_system3.27362277
3MP0003195_calcinosis3.20472682
4MP0002102_abnormal_ear_morphology2.98633578
5MP0002009_preneoplasia2.89806961
6MP0001835_abnormal_antigen_presentation2.84292491
7MP0008057_abnormal_DNA_replication2.83533889
8MP0008877_abnormal_DNA_methylation2.78865055
9MP0002006_tumorigenesis2.72326904
10MP0002166_altered_tumor_susceptibility2.61290464
11MP0001800_abnormal_humoral_immune2.48042045
12MP0003763_abnormal_thymus_physiology2.42337892
13MP0005671_abnormal_response_to2.35698521
14MP0006054_spinal_hemorrhage2.28166980
15MP0005174_abnormal_tail_pigmentation2.25117223
16MP0003300_gastrointestinal_ulcer2.21784453
17MP0003303_peritoneal_inflammation2.20939723
18MP0001790_abnormal_immune_system2.20410231
19MP0005387_immune_system_phenotype2.20410231
20MP0002452_abnormal_antigen_presenting2.11105602
21MP0000372_irregular_coat_pigmentation2.09043306
22MP0002938_white_spotting2.05742467
23MP0004808_abnormal_hematopoietic_stem2.05542203
24MP0010234_abnormal_vibrissa_follicle2.04911275
25MP0002420_abnormal_adaptive_immunity2.00292296
26MP0002398_abnormal_bone_marrow2.00074920
27MP0001819_abnormal_immune_cell1.96905190
28MP0005000_abnormal_immune_tolerance1.96635054
29MP0010307_abnormal_tumor_latency1.95449184
30MP0010094_abnormal_chromosome_stability1.94858372
31MP0006072_abnormal_retinal_apoptosis1.94149378
32MP0002254_reproductive_system_inflammat1.89731885
33MP0003880_abnormal_central_pattern1.88503710
34MP0002723_abnormal_immune_serum1.86841784
35MP0001984_abnormal_olfaction1.79546455
36MP0002419_abnormal_innate_immunity1.79227606
37MP0000703_abnormal_thymus_morphology1.71510148
38MP0003436_decreased_susceptibility_to1.70799016
39MP0000716_abnormal_immune_system1.70065476
40MP0000685_abnormal_immune_system1.68797783
41MP0003937_abnormal_limbs/digits/tail_de1.66890329
42MP0004215_abnormal_myocardial_fiber1.64129839
43MP0005076_abnormal_cell_differentiation1.62172002
44MP0005025_abnormal_response_to1.61444589
45MP0005551_abnormal_eye_electrophysiolog1.60298253
46MP0010352_gastrointestinal_tract_polyps1.59775677
47MP0005253_abnormal_eye_physiology1.59222928
48MP0002751_abnormal_autonomic_nervous1.56097554
49MP0000689_abnormal_spleen_morphology1.55163065
50MP0002405_respiratory_system_inflammati1.54317821
51MP0002148_abnormal_hypersensitivity_rea1.53650789
52MP0002722_abnormal_immune_system1.52430583
53MP0010155_abnormal_intestine_physiology1.49897578
54MP0004957_abnormal_blastocyst_morpholog1.48756272
55MP0003121_genomic_imprinting1.48596946
56MP0000465_gastrointestinal_hemorrhage1.44540783
57MP0000015_abnormal_ear_pigmentation1.43745351
58MP0003111_abnormal_nucleus_morphology1.43487522
59MP0002736_abnormal_nociception_after1.43342002
60MP0003119_abnormal_digestive_system1.41365746
61MP0001485_abnormal_pinna_reflex1.41223622
62MP0009785_altered_susceptibility_to1.38543682
63MP0002234_abnormal_pharynx_morphology1.38467384
64MP0005409_darkened_coat_color1.38213002
65MP0002233_abnormal_nose_morphology1.38124405
66MP0002095_abnormal_skin_pigmentation1.37734890
67MP0003718_maternal_effect1.37544303
68MP0000490_abnormal_crypts_of1.36336043
69MP0002429_abnormal_blood_cell1.35609504
70MP0001851_eye_inflammation1.34647962
71MP0003077_abnormal_cell_cycle1.32799091
72MP0010678_abnormal_skin_adnexa1.30991986
73MP0003787_abnormal_imprinting1.29509768
74MP0004133_heterotaxia1.28596775
75MP0001545_abnormal_hematopoietic_system1.27029460
76MP0005397_hematopoietic_system_phenotyp1.27029460
77MP0003045_fibrosis1.26743863
78MP0003786_premature_aging1.25968913
79MP0003448_altered_tumor_morphology1.25452959
80MP0002837_dystrophic_cardiac_calcinosis1.21907194
81MP0005464_abnormal_platelet_physiology1.21342230
82MP0000647_abnormal_sebaceous_gland1.19605661
83MP0002090_abnormal_vision1.17729307
84MP0001986_abnormal_taste_sensitivity1.17708551
85MP0005075_abnormal_melanosome_morpholog1.17306575
86MP0003283_abnormal_digestive_organ1.17114215
87MP0005367_renal/urinary_system_phenotyp1.16509247
88MP0000516_abnormal_urinary_system1.16509247
89MP0008007_abnormal_cellular_replicative1.14142585
90MP0003755_abnormal_palate_morphology1.13394226
91MP0000383_abnormal_hair_follicle1.13319591
92MP0008872_abnormal_physiological_respon1.13073695
93MP0001873_stomach_inflammation1.12582317
94MP0000858_altered_metastatic_potential1.11888336
95MP0002282_abnormal_trachea_morphology1.10938801
96MP0005408_hypopigmentation1.10152300
97MP0003890_abnormal_embryonic-extraembry1.07764658
98MP0005084_abnormal_gallbladder_morpholo1.07540025
99MP0004147_increased_porphyrin_level1.05881079
100MP0001845_abnormal_inflammatory_respons1.05726475
101MP0005395_other_phenotype1.05589967
102MP0003693_abnormal_embryo_hatching1.04716395
103MP0003941_abnormal_skin_development1.02842671
104MP0003183_abnormal_peptide_metabolism1.02114196
105MP0000631_abnormal_neuroendocrine_gland1.01764660
106MP0003950_abnormal_plasma_membrane1.00499947
107MP0008961_abnormal_basal_metabolism1.00124190
108MP0002132_abnormal_respiratory_system0.99984501
109MP0001177_atelectasis0.97975413
110MP0003866_abnormal_defecation0.97330859
111MP0003567_abnormal_fetal_cardiomyocyte0.97172248
112MP0009780_abnormal_chondrocyte_physiolo0.96844192
113MP0006082_CNS_inflammation0.96577460
114MP0008995_early_reproductive_senescence0.96413061
115MP0005248_abnormal_Harderian_gland0.95893512
116MP0001529_abnormal_vocalization0.95865321
117MP0003453_abnormal_keratinocyte_physiol0.95853335
118MP0002019_abnormal_tumor_incidence0.95848636
119MP0001286_abnormal_eye_development0.95765266
120MP0001929_abnormal_gametogenesis0.95502844
121MP0002168_other_aberrant_phenotype0.95430829
122MP0002160_abnormal_reproductive_system0.95352517
123MP0008058_abnormal_DNA_repair0.95274359
124MP0002084_abnormal_developmental_patter0.92335172
125MP0008775_abnormal_heart_ventricle0.92269448
126MP0000427_abnormal_hair_cycle0.91817503
127MP0008932_abnormal_embryonic_tissue0.90674910
128MP0003943_abnormal_hepatobiliary_system0.90430647
129MP0005389_reproductive_system_phenotype0.88709433
130MP0004947_skin_inflammation0.88182597
131MP0003137_abnormal_impulse_conducting0.88138183
132MP0001293_anophthalmia0.87514306
133MP0002075_abnormal_coat/hair_pigmentati0.87376503
134MP0002998_abnormal_bone_remodeling0.87347558
135MP0002928_abnormal_bile_duct0.87251685
136MP0005646_abnormal_pituitary_gland0.87237397
137MP0004381_abnormal_hair_follicle0.87099511
138MP0004085_abnormal_heartbeat0.86439503
139MP0003828_pulmonary_edema0.85732706
140MP0005379_endocrine/exocrine_gland_phen0.85475006
141MP0000653_abnormal_sex_gland0.85146369
142MP0000733_abnormal_muscle_development0.85005825
143MP0001764_abnormal_homeostasis0.84594221
144MP0003935_abnormal_craniofacial_develop0.83794970
145MP0002210_abnormal_sex_determination0.83621237
146MP0001486_abnormal_startle_reflex0.83194616
147MP0005220_abnormal_exocrine_pancreas0.83031954
148MP0001119_abnormal_female_reproductive0.81978308
149MP0000538_abnormal_urinary_bladder0.80747525
150MP0000613_abnormal_salivary_gland0.79601327
151MP0004510_myositis0.79093009
152MP0009703_decreased_birth_body0.79082275
153MP0001968_abnormal_touch/_nociception0.78627459
154MP0003566_abnormal_cell_adhesion0.78028072
155MP0005187_abnormal_penis_morphology0.77165807
156MP0006292_abnormal_olfactory_placode0.76507118
157MP0003172_abnormal_lysosome_physiology0.76094782
158MP0005394_taste/olfaction_phenotype0.75766854
159MP0005499_abnormal_olfactory_system0.75766854
160MP0001145_abnormal_male_reproductive0.75577676
161MP0001324_abnormal_eye_pigmentation0.75026279
162MP0005391_vision/eye_phenotype0.74366104
163MP0000778_abnormal_nervous_system0.74200571
164MP0002111_abnormal_tail_morphology0.73962750
165MP0003091_abnormal_cell_migration0.73041369
166MP0000350_abnormal_cell_proliferation0.72921522
167MP0002933_joint_inflammation0.72435839
168MP0001191_abnormal_skin_condition0.72308874
169MP0008004_abnormal_stomach_pH0.71903007
170MP0009697_abnormal_copulation0.71552086
171MP0000627_abnormal_mammary_gland0.69806090
172MP0002086_abnormal_extraembryonic_tissu0.69640516
173MP0009333_abnormal_splenocyte_physiolog0.69629260
174MP0001853_heart_inflammation0.69172416
175MP0005310_abnormal_salivary_gland0.68758018
176MP0005171_absent_coat_pigmentation0.68546945

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)3.56864688
2Chromsome breakage (HP:0040012)3.24296591
3Recurrent abscess formation (HP:0002722)3.22557388
4Eczematoid dermatitis (HP:0000976)3.22468587
5Intestinal atresia (HP:0011100)3.13621431
6Asymmetry of the thorax (HP:0001555)3.13392947
7Volvulus (HP:0002580)3.09173051
8Pancreatic cysts (HP:0001737)3.08703918
9Abnormality of the fingertips (HP:0001211)3.06673897
10Recurrent bacterial skin infections (HP:0005406)3.05999660
11T lymphocytopenia (HP:0005403)3.04170767
12Meckel diverticulum (HP:0002245)2.95054653
13Abnormality of the ileum (HP:0001549)2.93531563
14Prostate neoplasm (HP:0100787)2.92853225
15Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92243772
16Thyroiditis (HP:0100646)2.90051747
17Abnormality of the labia minora (HP:0012880)2.87231155
18True hermaphroditism (HP:0010459)2.83502123
19Abnormality of T cell number (HP:0011839)2.83218564
20Recurrent fungal infections (HP:0002841)2.81120752
21Pancreatic fibrosis (HP:0100732)2.80914025
22Molar tooth sign on MRI (HP:0002419)2.75201310
23Abnormality of midbrain morphology (HP:0002418)2.75201310
24Recurrent viral infections (HP:0004429)2.70875983
25Acute myeloid leukemia (HP:0004808)2.69101142
26Neoplasm of the adrenal cortex (HP:0100641)2.65903012
27Abnormality of the prostate (HP:0008775)2.62569827
28Methylmalonic acidemia (HP:0002912)2.57664939
29Lymphopenia (HP:0001888)2.55538092
30Bifid tongue (HP:0010297)2.52682103
31Abnormality of aspartate family amino acid metabolism (HP:0010899)2.50477687
32Ependymoma (HP:0002888)2.50169341
33Retrobulbar optic neuritis (HP:0100654)2.48754283
34Optic neuritis (HP:0100653)2.48754283
35Abnormality of the renal cortex (HP:0011035)2.47417667
36Aqueductal stenosis (HP:0002410)2.47399403
37Myositis (HP:0100614)2.46655016
38Abnormality of methionine metabolism (HP:0010901)2.45765394
39Glioma (HP:0009733)2.45020494
40Absent frontal sinuses (HP:0002688)2.44577170
41Pancreatic islet-cell hyperplasia (HP:0004510)2.44412156
42Abnormality of the duodenum (HP:0002246)2.43292479
43Duodenal stenosis (HP:0100867)2.41829819
44Small intestinal stenosis (HP:0012848)2.41829819
45Nephronophthisis (HP:0000090)2.41749393
46Hematochezia (HP:0002573)2.40770175
47Abnormality of T cells (HP:0002843)2.39841053
48Abnormality of cells of the lymphoid lineage (HP:0012140)2.39648663
49Obstructive lung disease (HP:0006536)2.39040115
50Chronic obstructive pulmonary disease (HP:0006510)2.39040115
51Abnormality of the astrocytes (HP:0100707)2.38759159
52Astrocytoma (HP:0009592)2.38759159
53Cheilitis (HP:0100825)2.33880270
54Hypothermia (HP:0002045)2.32953942
55Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.32848041
56Renal cortical cysts (HP:0000803)2.31415842
57Mediastinal lymphadenopathy (HP:0100721)2.30768521
58Cellulitis (HP:0100658)2.28450734
59Disinhibition (HP:0000734)2.27533848
60Neoplasm of the adrenal gland (HP:0100631)2.27350946
61Abnormality of chromosome stability (HP:0003220)2.25224025
62Recurrent cutaneous fungal infections (HP:0011370)2.24506921
63Chronic mucocutaneous candidiasis (HP:0002728)2.24506921
64Abnormal lung lobation (HP:0002101)2.24451799
65Progressive inability to walk (HP:0002505)2.24101052
66Blepharitis (HP:0000498)2.22697462
67Agnosia (HP:0010524)2.22100700
68Meningitis (HP:0001287)2.21996610
69Colon cancer (HP:0003003)2.21899565
70Papilledema (HP:0001085)2.20341528
71Thoracic kyphosis (HP:0002942)2.20215487
72Alopecia of scalp (HP:0002293)2.19996940
73Abnormality of the renal medulla (HP:0100957)2.19001355
74Aplasia/Hypoplasia of the tongue (HP:0010295)2.18606744
75Periodontitis (HP:0000704)2.18471941
76IgM deficiency (HP:0002850)2.15598812
77Sloping forehead (HP:0000340)2.15321491
78Ectopic kidney (HP:0000086)2.14954800
79Medial flaring of the eyebrow (HP:0010747)2.14879049
80Orchitis (HP:0100796)2.14777624
81Chronic diarrhea (HP:0002028)2.10051447
82Clubbing of toes (HP:0100760)2.08253558
83Recurrent gram-negative bacterial infections (HP:0005420)2.08062172
84Midline defect of the nose (HP:0004122)2.07677765
85Oligodactyly (hands) (HP:0001180)2.07574168
86Genital tract atresia (HP:0001827)2.06728622
87Breast carcinoma (HP:0003002)2.05682025
88Syringomyelia (HP:0003396)2.03974929
89Spinal cord lesions (HP:0100561)2.03974929
90Recurrent skin infections (HP:0001581)2.03654690
91Abnormal biliary tract morphology (HP:0012440)2.02966146
92Hyperventilation (HP:0002883)2.02961260
93Agammaglobulinemia (HP:0004432)2.02329349
94Hypoplastic labia majora (HP:0000059)2.02255997
95Arterial thrombosis (HP:0004420)2.01147375
96Gastrointestinal atresia (HP:0002589)2.00079910
97Panhypogammaglobulinemia (HP:0003139)1.99932100
98Abnormality of the thoracic spine (HP:0100711)1.99747672
99Inappropriate behavior (HP:0000719)1.99613032
100Rhabdomyosarcoma (HP:0002859)1.99272562
101Deep philtrum (HP:0002002)1.99200734
102Myelodysplasia (HP:0002863)1.99120075
103Vaginal atresia (HP:0000148)1.97657222
104Spondylolisthesis (HP:0003302)1.96695289
105Chronic hepatic failure (HP:0100626)1.96688105
106Parakeratosis (HP:0001036)1.94744705
107Keratoconjunctivitis sicca (HP:0001097)1.94023644
108Recurrent bronchitis (HP:0002837)1.93010685
109Fibular aplasia (HP:0002990)1.92879490
110Curly hair (HP:0002212)1.92038450
111Narrow palate (HP:0000189)1.91670259
112Subacute progressive viral hepatitis (HP:0006572)1.90033027
113Disproportionate short-trunk short stature (HP:0003521)1.89750692
114Small hand (HP:0200055)1.89263661
115Embryonal renal neoplasm (HP:0011794)1.89260129
116Abnormal pancreas size (HP:0012094)1.88890289
117Abnormality of the pancreatic islet cells (HP:0006476)1.88875862
118Abnormality of endocrine pancreas physiology (HP:0012093)1.88875862
119Hypoplastic pelvis (HP:0008839)1.87489551
120Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87018143
121Labial hypoplasia (HP:0000066)1.87011758
122Chronic sinusitis (HP:0011109)1.86166442
123Abnormal delayed hypersensitivity skin test (HP:0002963)1.85631555
124Hypoproteinemia (HP:0003075)1.84942793
125Abnormality of vitamin B metabolism (HP:0004340)1.84939080
126Severe combined immunodeficiency (HP:0004430)1.84117916
127Inflammation of the large intestine (HP:0002037)1.83627423
128Renal hypoplasia (HP:0000089)1.83445009
129Hypoglycemic seizures (HP:0002173)1.83421925
130White forelock (HP:0002211)1.80942698
131Hypoplastic female external genitalia (HP:0012815)1.80880017
132Gingivitis (HP:0000230)1.80589950
133Abnormality of the labia majora (HP:0012881)1.80060049
134Methylmalonic aciduria (HP:0012120)1.79772303
135Supernumerary spleens (HP:0009799)1.79705255
136Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78935122
137Short 4th metacarpal (HP:0010044)1.78935122
138Preaxial hand polydactyly (HP:0001177)1.78850934
139Long eyelashes (HP:0000527)1.78741148
140Bilateral sensorineural hearing impairment (HP:0008619)1.78305341
141Astigmatism (HP:0000483)1.76979869
142Macroorchidism (HP:0000053)1.76778863
143Ectropion (HP:0000656)1.76316687
144Abnormality of the vitamin B12 metabolism (HP:0004341)1.76168766
145Abnormality of eosinophils (HP:0001879)1.75772696
146Vasculitis (HP:0002633)1.75342351
147Prominent nose (HP:0000448)1.75031831
148Congenital primary aphakia (HP:0007707)1.74596421
149High pitched voice (HP:0001620)1.74309766
150Fair hair (HP:0002286)1.74173454
151Postaxial foot polydactyly (HP:0001830)1.73974418
152Gonadotropin excess (HP:0000837)1.73931530
153Hypochromic microcytic anemia (HP:0004840)1.73679303
154Adrenal hypoplasia (HP:0000835)1.73655590
155Biliary tract neoplasm (HP:0100574)1.73642479
156Leukocytosis (HP:0001974)1.73202392
157Trigonocephaly (HP:0000243)1.72941998
158Colitis (HP:0002583)1.72830482
159Furrowed tongue (HP:0000221)1.72424188
160Triphalangeal thumb (HP:0001199)1.72204253
161Keratoconjunctivitis (HP:0001096)1.71547690
162Sclerocornea (HP:0000647)1.71199437
163Absent radius (HP:0003974)1.71197502
164IgA deficiency (HP:0002720)1.71158296
165Viral hepatitis (HP:0006562)1.70851544
166Abnormality of the nasal septum (HP:0000419)1.70238778
167Spontaneous hematomas (HP:0007420)1.69824653
168Dandy-Walker malformation (HP:0001305)1.69393423
169Transitional cell carcinoma of the bladder (HP:0006740)1.69364424
170Eosinophilia (HP:0001880)1.69294196
171Cystic liver disease (HP:0006706)1.68663922
172Oligohydramnios (HP:0001562)1.68653641
173Septo-optic dysplasia (HP:0100842)1.68633622
174Hamartoma of the eye (HP:0010568)1.68493468
175Abnormality of the parathyroid morphology (HP:0011766)1.68071926
176Encephalitis (HP:0002383)1.67376378
177Combined immunodeficiency (HP:0005387)1.67211260
178Optic nerve hypoplasia (HP:0000609)1.66557899
179Abnormality of the preputium (HP:0100587)1.66006127
180Aplasia/Hypoplasia of the uvula (HP:0010293)1.65859049
181Nephroblastoma (Wilms tumor) (HP:0002667)1.65771434
182Postaxial hand polydactyly (HP:0001162)1.65471265
183Hyperinsulinemic hypoglycemia (HP:0000825)1.65437986
184Gait imbalance (HP:0002141)1.65371551
185Hypoplasia of the fovea (HP:0007750)1.64931005
186Aplasia/Hypoplasia of the fovea (HP:0008060)1.64931005
187Lymphoma (HP:0002665)1.64697292
188Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.64105604
189Thrombocytosis (HP:0001894)1.63629159
190Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63276017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.69212479
2ACVR1B3.12170624
3BMPR1B3.02600268
4EIF2AK32.84313992
5MKNK22.76809103
6MAP3K142.72225477
7MST42.60470312
8MAP4K22.50700417
9TNIK2.45666847
10WNK32.44515475
11SIK22.43958525
12MAP4K12.37883872
13BRSK22.27083869
14TXK2.15328636
15CDK122.14703359
16IRAK42.13120638
17SIK32.09563741
18STK102.02297299
19RIPK41.96695178
20FGFR31.95126704
21LATS11.92940470
22FRK1.91630220
23CDC71.91174996
24TEC1.83021963
25CASK1.82931494
26MKNK11.82675965
27PBK1.81489913
28EPHA31.80644928
29JAK11.80576229
30SGK21.78016862
31JAK31.77474574
32ITK1.76183185
33BUB11.74514490
34BCR1.66468429
35NUAK11.63612113
36WEE11.62751729
37SGK31.61386828
38MAPK131.60044361
39EIF2AK11.59412370
40PLK21.58955168
41PLK41.56634329
42TYK21.50588525
43EEF2K1.50042830
44STK31.48460941
45FGFR21.48298226
46CSF1R1.47611822
47STK41.45190512
48TSSK61.44891400
49NEK91.41934936
50STK391.41724380
51CDK61.40929327
52NEK11.40710100
53CSK1.34331188
54KIT1.33608346
55PIM11.33117911
56YES11.33078851
57CCNB11.31240923
58TGFBR11.30379716
59ZAK1.28243934
60AKT31.26792710
61HCK1.22996860
62TAOK31.21931836
63GRK11.19907518
64NLK1.18933165
65BRD41.18900123
66PNCK1.16871778
67CDK91.16539563
68NEK21.13811503
69CAMK1G1.13709680
70BTK1.12931865
71TGFBR21.12596261
72CDK31.11575491
73MELK1.11471830
74MAP3K131.10896405
75DMPK1.10126929
76STK38L1.08910307
77CLK11.07251313
78CAMK1D1.05951311
79PRPF4B1.05800276
80OXSR11.04049129
81MAP3K41.03487272
82PRKD31.02152915
83SRPK11.02042417
84PRKCQ1.00823076
85ATR1.00306896
86EPHA41.00124215
87MARK30.99747719
88ERBB40.97163578
89SIK10.95667889
90PAK30.95339086
91IKBKE0.94972828
92TRPM70.94723311
93TAF10.94571637
94LCK0.94155970
95CHUK0.93718587
96SYK0.91620056
97ERBB30.88867833
98GRK60.88142685
99PLK10.84843319
100PRKCE0.82974457
101INSRR0.81651318
102IKBKB0.80921346
103TAOK20.80438331
104FER0.79624122
105CDK80.78529665
106JAK20.78412388
107CHEK20.76506179
108BRSK10.74910375
109ADRBK20.74902413
110LYN0.74475995
111ATM0.73032938
112MAP3K100.72412460
113CSNK1G10.71753529
114TLK10.71660610
115EIF2AK20.66686689
116TTK0.66135504
117MAP3K120.64898659
118PINK10.63885246
119FGR0.63651556
120MAPK70.63049802
121PLK30.61242891
122CDK40.61138689
123CSNK1D0.60953017
124IRAK30.59551194
125FLT30.58890740
126ALK0.57499771
127PDGFRB0.57221417
128CDK70.57205217
129RPS6KA40.56165257
130MINK10.54850967
131MAP3K50.54838571
132ABL10.54149898
133FGFR10.54039398
134BMPR20.53731841
135VRK10.52071583
136PDK20.50922869
137FES0.50036518
138CSNK1G20.49968388
139CHEK10.49283671
140SGK10.49160913
141ADRBK10.47583848
142DYRK1B0.46517107
143SGK4940.45294706
144SGK2230.45294706
145STK240.45187581
146WNK10.43618155
147ROCK10.42549568
148MAP3K80.41829334
149CSNK1A1L0.40279682
150PASK0.40277879
151CDK20.37795890
152EGFR0.36779811
153CSNK1G30.35389074
154PRKCG0.34933680
155WNK40.33261262
156PKN10.33260539
157IRAK10.32851049
158MAPKAPK30.31054969
159NTRK30.29391547
160VRK20.29057017
161OBSCN0.26807851
162ROCK20.26033054
163MUSK0.24596807
164PRKDC0.23696174
165MARK10.23247424
166IGF1R0.22591625
167AURKB0.21593327
168IRAK20.20799710

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.26886980
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.16348506
3Propanoate metabolism_Homo sapiens_hsa006402.89404910
4Primary immunodeficiency_Homo sapiens_hsa053402.63807517
5Proteasome_Homo sapiens_hsa030502.56312437
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28027410
7Basal transcription factors_Homo sapiens_hsa030222.14157749
8B cell receptor signaling pathway_Homo sapiens_hsa046622.12328410
9Butanoate metabolism_Homo sapiens_hsa006502.12198318
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10920631
11Steroid biosynthesis_Homo sapiens_hsa001002.03527395
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.86300809
13T cell receptor signaling pathway_Homo sapiens_hsa046601.85114526
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82711790
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.80594111
16Non-homologous end-joining_Homo sapiens_hsa034501.78387726
17Leishmaniasis_Homo sapiens_hsa051401.78238593
18Osteoclast differentiation_Homo sapiens_hsa043801.78179489
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.76656882
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.69946458
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69867651
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61570360
23Phototransduction_Homo sapiens_hsa047441.60489278
24Vitamin B6 metabolism_Homo sapiens_hsa007501.59733290
25Measles_Homo sapiens_hsa051621.57421223
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.53152309
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.52589103
28Hematopoietic cell lineage_Homo sapiens_hsa046401.49827519
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.49091999
30RNA transport_Homo sapiens_hsa030131.44610396
31Fanconi anemia pathway_Homo sapiens_hsa034601.42380247
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40514202
33Chronic myeloid leukemia_Homo sapiens_hsa052201.40488479
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.38117439
35Pancreatic cancer_Homo sapiens_hsa052121.37627568
36Systemic lupus erythematosus_Homo sapiens_hsa053221.36540732
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34682695
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34426277
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31616137
40Toxoplasmosis_Homo sapiens_hsa051451.27776704
41Selenocompound metabolism_Homo sapiens_hsa004501.25696327
42Fatty acid elongation_Homo sapiens_hsa000621.25342125
43Oocyte meiosis_Homo sapiens_hsa041141.25022848
44Hepatitis B_Homo sapiens_hsa051611.24379017
45Acute myeloid leukemia_Homo sapiens_hsa052211.23509360
46MicroRNAs in cancer_Homo sapiens_hsa052061.23054594
47Colorectal cancer_Homo sapiens_hsa052101.22927138
48Herpes simplex infection_Homo sapiens_hsa051681.22659233
49Cell cycle_Homo sapiens_hsa041101.19859700
50Chemokine signaling pathway_Homo sapiens_hsa040621.19745186
51Caffeine metabolism_Homo sapiens_hsa002321.18195850
52Nucleotide excision repair_Homo sapiens_hsa034201.17783743
53Leukocyte transendothelial migration_Homo sapiens_hsa046701.15560499
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14950436
55Non-small cell lung cancer_Homo sapiens_hsa052231.14946641
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12849092
57Tuberculosis_Homo sapiens_hsa051521.10855871
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.10715685
59RNA polymerase_Homo sapiens_hsa030201.10333867
60DNA replication_Homo sapiens_hsa030301.09919630
61Nitrogen metabolism_Homo sapiens_hsa009101.09628778
62Tryptophan metabolism_Homo sapiens_hsa003801.08437928
63TNF signaling pathway_Homo sapiens_hsa046681.06345268
64Platelet activation_Homo sapiens_hsa046111.06165451
65Ether lipid metabolism_Homo sapiens_hsa005651.05962569
66Antigen processing and presentation_Homo sapiens_hsa046121.05587978
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05494319
68Adherens junction_Homo sapiens_hsa045201.05441590
69Mismatch repair_Homo sapiens_hsa034301.05205953
70Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03668008
71Pyruvate metabolism_Homo sapiens_hsa006201.03380124
72Viral myocarditis_Homo sapiens_hsa054161.02333610
73Graft-versus-host disease_Homo sapiens_hsa053321.02087196
74Primary bile acid biosynthesis_Homo sapiens_hsa001201.01538574
75Viral carcinogenesis_Homo sapiens_hsa052031.01227807
76Peroxisome_Homo sapiens_hsa041460.98572067
77One carbon pool by folate_Homo sapiens_hsa006700.98507797
78HTLV-I infection_Homo sapiens_hsa051660.98080277
79Small cell lung cancer_Homo sapiens_hsa052220.96575863
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96487278
81Fatty acid degradation_Homo sapiens_hsa000710.96237191
82Allograft rejection_Homo sapiens_hsa053300.94514997
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93692385
84Prostate cancer_Homo sapiens_hsa052150.93446820
85Circadian rhythm_Homo sapiens_hsa047100.89625879
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89501629
87Homologous recombination_Homo sapiens_hsa034400.89056760
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88939253
89Apoptosis_Homo sapiens_hsa042100.88916197
90FoxO signaling pathway_Homo sapiens_hsa040680.87763391
91Influenza A_Homo sapiens_hsa051640.87259076
92Malaria_Homo sapiens_hsa051440.87222954
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86175348
94Retinol metabolism_Homo sapiens_hsa008300.86081646
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86025670
96Regulation of autophagy_Homo sapiens_hsa041400.85883338
97Glioma_Homo sapiens_hsa052140.85846561
98Fatty acid metabolism_Homo sapiens_hsa012120.85358990
99Olfactory transduction_Homo sapiens_hsa047400.85341788
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85100232
101Endometrial cancer_Homo sapiens_hsa052130.83661550
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82731286
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82615777
104p53 signaling pathway_Homo sapiens_hsa041150.82580350
105Hippo signaling pathway_Homo sapiens_hsa043900.81639298
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80986283
107African trypanosomiasis_Homo sapiens_hsa051430.80940546
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79919716
109Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79905576
110Hedgehog signaling pathway_Homo sapiens_hsa043400.79509624
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78346346
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78266259
113Linoleic acid metabolism_Homo sapiens_hsa005910.78259224
114RNA degradation_Homo sapiens_hsa030180.78240405
115ErbB signaling pathway_Homo sapiens_hsa040120.77053470
116beta-Alanine metabolism_Homo sapiens_hsa004100.76311128
117Base excision repair_Homo sapiens_hsa034100.75285469
118Purine metabolism_Homo sapiens_hsa002300.74430533
119N-Glycan biosynthesis_Homo sapiens_hsa005100.72679038
120MAPK signaling pathway_Homo sapiens_hsa040100.72604873
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72501055
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.71595669
123Inositol phosphate metabolism_Homo sapiens_hsa005620.71584928
124Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71173479
125Pertussis_Homo sapiens_hsa051330.69986923
126Prolactin signaling pathway_Homo sapiens_hsa049170.69009263
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68289050
128Melanoma_Homo sapiens_hsa052180.67472186
129TGF-beta signaling pathway_Homo sapiens_hsa043500.66705246
130Salmonella infection_Homo sapiens_hsa051320.66662673
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66489490
132Shigellosis_Homo sapiens_hsa051310.66346425
133mRNA surveillance pathway_Homo sapiens_hsa030150.63475796
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63456521
135Proteoglycans in cancer_Homo sapiens_hsa052050.63162699
136Taste transduction_Homo sapiens_hsa047420.62820585
137Pathways in cancer_Homo sapiens_hsa052000.62764027
138Lysine degradation_Homo sapiens_hsa003100.62380635
139Sulfur metabolism_Homo sapiens_hsa009200.61409914
140Asthma_Homo sapiens_hsa053100.61407043
141Renal cell carcinoma_Homo sapiens_hsa052110.61334453
142mTOR signaling pathway_Homo sapiens_hsa041500.60778767
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60063404
144Notch signaling pathway_Homo sapiens_hsa043300.59496214
145Legionellosis_Homo sapiens_hsa051340.57869041
146* Wnt signaling pathway_Homo sapiens_hsa043100.57555524
147Chemical carcinogenesis_Homo sapiens_hsa052040.57434020
148Rap1 signaling pathway_Homo sapiens_hsa040150.57123730
149Choline metabolism in cancer_Homo sapiens_hsa052310.56958612
150Glutathione metabolism_Homo sapiens_hsa004800.56939707
151Staphylococcus aureus infection_Homo sapiens_hsa051500.56090337
152Nicotine addiction_Homo sapiens_hsa050330.55754182
153Steroid hormone biosynthesis_Homo sapiens_hsa001400.55417099
154Long-term depression_Homo sapiens_hsa047300.54986474
155VEGF signaling pathway_Homo sapiens_hsa043700.54522605
156Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53883058
157Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52995102
158Hepatitis C_Homo sapiens_hsa051600.52911801
159Basal cell carcinoma_Homo sapiens_hsa052170.52165306
160Sphingolipid metabolism_Homo sapiens_hsa006000.52062773
161Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51329784
162Metabolic pathways_Homo sapiens_hsa011000.51092122
163Autoimmune thyroid disease_Homo sapiens_hsa053200.50484164
164Sphingolipid signaling pathway_Homo sapiens_hsa040710.50437772
165Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49604032
166Glycerolipid metabolism_Homo sapiens_hsa005610.49087295
167Ras signaling pathway_Homo sapiens_hsa040140.48438164
168Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48302466
169Insulin secretion_Homo sapiens_hsa049110.47573761
170Dorso-ventral axis formation_Homo sapiens_hsa043200.46130279
171Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45676240
172Histidine metabolism_Homo sapiens_hsa003400.44439434
173Vitamin digestion and absorption_Homo sapiens_hsa049770.43615616
174Amphetamine addiction_Homo sapiens_hsa050310.41731034
1752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40769715
176Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40741454
177Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40717151
178Tight junction_Homo sapiens_hsa045300.38579065
179Dopaminergic synapse_Homo sapiens_hsa047280.37650341
180ABC transporters_Homo sapiens_hsa020100.36784222
181Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36146922
182Pyrimidine metabolism_Homo sapiens_hsa002400.35656707
183Serotonergic synapse_Homo sapiens_hsa047260.35547048
184SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35343572

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