TBL1Y

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene is highly similar to TBL1X gene in nucleotide sequence and protein sequence, but the TBL1X gene is located on chromosome X and this gene is on chromosome Y. This gene has three alternatively spliced transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-serine metabolic process (GO:0006563)4.72496937
2lysine catabolic process (GO:0006554)4.14880460
3lysine metabolic process (GO:0006553)4.14880460
4chromatin remodeling at centromere (GO:0031055)4.07939802
5presynaptic membrane assembly (GO:0097105)3.88871482
6regulation of mitochondrial translation (GO:0070129)3.82917569
7chaperone-mediated protein transport (GO:0072321)3.82857994
8establishment of protein localization to mitochondrial membrane (GO:0090151)3.78118872
9CENP-A containing nucleosome assembly (GO:0034080)3.74605683
10water-soluble vitamin biosynthetic process (GO:0042364)3.54314577
11regulation of DNA endoreduplication (GO:0032875)3.52383723
12intraciliary transport (GO:0042073)3.48582683
13somatic diversification of immune receptors via somatic mutation (GO:0002566)3.44648098
14somatic hypermutation of immunoglobulin genes (GO:0016446)3.44648098
15cytochrome complex assembly (GO:0017004)3.44469596
16serine family amino acid biosynthetic process (GO:0009070)3.31795799
17respiratory chain complex IV assembly (GO:0008535)3.29331402
18negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.27492833
19cholesterol biosynthetic process (GO:0006695)3.23141135
20negative regulation of DNA-dependent DNA replication (GO:2000104)3.22582760
21nonmotile primary cilium assembly (GO:0035058)3.21607201
22histone exchange (GO:0043486)3.20741538
23establishment of integrated proviral latency (GO:0075713)3.17490276
24response to nitrosative stress (GO:0051409)3.13200786
25sterol biosynthetic process (GO:0016126)3.10534680
26calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.05371493
27dorsal/ventral axis specification (GO:0009950)3.02992194
28protein complex biogenesis (GO:0070271)3.00028720
29presynaptic membrane organization (GO:0097090)2.99455593
30DNA replication-independent nucleosome assembly (GO:0006336)2.98106922
31DNA replication-independent nucleosome organization (GO:0034724)2.98106922
32branched-chain amino acid catabolic process (GO:0009083)2.97109456
33aspartate family amino acid catabolic process (GO:0009068)2.96064471
34tongue development (GO:0043586)2.94526523
35regulation of helicase activity (GO:0051095)2.94492727
36DNA replication-dependent nucleosome organization (GO:0034723)2.90294534
37DNA replication-dependent nucleosome assembly (GO:0006335)2.90294534
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89864625
39tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89864625
40lung-associated mesenchyme development (GO:0060484)2.87389122
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.87316310
42DNA strand renaturation (GO:0000733)2.86994921
43mitochondrial respiratory chain complex assembly (GO:0033108)2.85038249
44postsynaptic membrane organization (GO:0001941)2.84282180
45negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.81127813
46anterior/posterior axis specification, embryo (GO:0008595)2.80739608
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80536523
48replication fork processing (GO:0031297)2.75353266
49regulation of telomere maintenance via telomerase (GO:0032210)2.73102762
50regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.72972348
51regulation of mitotic spindle checkpoint (GO:1903504)2.72972348
52axonemal dynein complex assembly (GO:0070286)2.69673464
53retinal rod cell development (GO:0046548)2.65925229
54cellular response to cholesterol (GO:0071397)2.58898347
55DNA double-strand break processing (GO:0000729)2.57861875
56pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.55410409
57platelet dense granule organization (GO:0060155)2.55392009
58cullin deneddylation (GO:0010388)2.54879739
59otic vesicle formation (GO:0030916)2.54343920
60CTP metabolic process (GO:0046036)2.54070550
61CTP biosynthetic process (GO:0006241)2.54070550
62regulation of mesoderm development (GO:2000380)2.52942155
63regulation of centriole replication (GO:0046599)2.51732741
64regulation of retinoic acid receptor signaling pathway (GO:0048385)2.50177066
65telomere maintenance via semi-conservative replication (GO:0032201)2.48849278
66cellular response to sterol (GO:0036315)2.46677128
67serine family amino acid metabolic process (GO:0009069)2.46167752
68regulation of cilium movement (GO:0003352)2.45683053
69pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.45628467
70histone H2A acetylation (GO:0043968)2.44987226
71regulation of posttranscriptional gene silencing (GO:0060147)2.43203397
72regulation of gene silencing by miRNA (GO:0060964)2.43203397
73regulation of gene silencing by RNA (GO:0060966)2.43203397
74nodal signaling pathway (GO:0038092)2.42698190
75histone mRNA metabolic process (GO:0008334)2.42136293
76regulation of cell fate specification (GO:0042659)2.41189370
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.40449849
78DNA deamination (GO:0045006)2.39204276
79protein deneddylation (GO:0000338)2.38969096
80regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.38733935
81pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.38401877
82UMP metabolic process (GO:0046049)2.38401877
83pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.38401877
84UMP biosynthetic process (GO:0006222)2.38401877
85olfactory bulb development (GO:0021772)2.37781128
86pyrimidine nucleobase catabolic process (GO:0006208)2.37653808
87negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.36685601
88negative regulation of translation, ncRNA-mediated (GO:0040033)2.36685601
89regulation of translation, ncRNA-mediated (GO:0045974)2.36685601
90aldehyde catabolic process (GO:0046185)2.35217892
91DNA strand elongation involved in DNA replication (GO:0006271)2.34586745
92regulation of hexokinase activity (GO:1903299)2.34388129
93regulation of glucokinase activity (GO:0033131)2.34388129
94intra-S DNA damage checkpoint (GO:0031573)2.34118844
95establishment of viral latency (GO:0019043)2.33606168
96pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.33504398
97glycine metabolic process (GO:0006544)2.33400061
98proteasome assembly (GO:0043248)2.33311834
99DNA ligation (GO:0006266)2.31895787
100NADH dehydrogenase complex assembly (GO:0010257)2.31873670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.62093396
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.23917088
3E2F7_22180533_ChIP-Seq_HELA_Human2.96089589
4IGF1R_20145208_ChIP-Seq_DFB_Human2.92937081
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.60303344
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57064354
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.52735177
8ZNF274_21170338_ChIP-Seq_K562_Hela2.52139463
9VDR_22108803_ChIP-Seq_LS180_Human2.51694405
10EZH2_22144423_ChIP-Seq_EOC_Human2.47755277
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42011843
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40259919
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38399098
14IRF1_19129219_ChIP-ChIP_H3396_Human2.36666404
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09082300
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.05850078
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04098384
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.01324996
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00008174
20ELK1_19687146_ChIP-ChIP_HELA_Human1.95871519
21P300_19829295_ChIP-Seq_ESCs_Human1.93480846
22TAF15_26573619_Chip-Seq_HEK293_Human1.92511450
23FUS_26573619_Chip-Seq_HEK293_Human1.91921255
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90195035
25EWS_26573619_Chip-Seq_HEK293_Human1.85014989
26NANOG_16153702_ChIP-ChIP_HESCs_Human1.77804520
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.77261515
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67620597
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67112675
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.66847630
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58887618
32SOX2_16153702_ChIP-ChIP_HESCs_Human1.58043283
33FOXP3_21729870_ChIP-Seq_TREG_Human1.55038571
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54465273
35GBX2_23144817_ChIP-Seq_PC3_Human1.53020720
36GABP_19822575_ChIP-Seq_HepG2_Human1.51942836
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50658197
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50261475
39VDR_23849224_ChIP-Seq_CD4+_Human1.49847160
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.48703775
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47980888
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45031469
43* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40526049
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37780150
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35398315
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35310941
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35126311
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34751877
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34579739
50SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33634192
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28901298
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.28830541
53MYC_18940864_ChIP-ChIP_HL60_Human1.28062593
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25435684
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24960239
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24960239
57KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24960239
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24289262
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24257759
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22706014
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21132766
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.20488266
63TTF2_22483619_ChIP-Seq_HELA_Human1.18841756
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16729195
65MYC_18358816_ChIP-ChIP_MESCs_Mouse1.14759929
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.14491206
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13270790
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09978348
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09978348
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09828253
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08533658
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.08230518
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.07703277
74AR_21909140_ChIP-Seq_LNCAP_Human1.07645217
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05935516
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03241107
77DCP1A_22483619_ChIP-Seq_HELA_Human1.02192259
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01182979
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00580141
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00528368
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99985086
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99594771
83KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99310438
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99021875
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98971764
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97922313
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96966301
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94146013
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93695066
90TP53_22573176_ChIP-Seq_HFKS_Human0.93390057
91BCAT_22108803_ChIP-Seq_LS180_Human0.92860124
92SMAD4_21799915_ChIP-Seq_A2780_Human0.91985384
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91604546
94MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91523630
95NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91406942
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91102961
97SOX2_19829295_ChIP-Seq_ESCs_Human0.90834145
98NANOG_19829295_ChIP-Seq_ESCs_Human0.90834145
99KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90037041
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89692472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.25639807
2MP0006292_abnormal_olfactory_placode4.00381096
3MP0002653_abnormal_ependyma_morphology3.25947231
4MP0000566_synostosis3.02405810
5MP0003011_delayed_dark_adaptation2.70789642
6MP0002102_abnormal_ear_morphology2.66050121
7MP0008789_abnormal_olfactory_epithelium2.62403054
8MP0001293_anophthalmia2.61649099
9MP0003122_maternal_imprinting2.41227520
10MP0005499_abnormal_olfactory_system2.32437366
11MP0005394_taste/olfaction_phenotype2.32437366
12MP0001984_abnormal_olfaction2.26267466
13MP0003693_abnormal_embryo_hatching2.25007770
14MP0010030_abnormal_orbit_morphology2.23012235
15MP0005377_hearing/vestibular/ear_phenot2.18710708
16MP0003878_abnormal_ear_physiology2.18710708
17MP0010094_abnormal_chromosome_stability2.13155785
18MP0008877_abnormal_DNA_methylation2.07929913
19MP0002254_reproductive_system_inflammat2.02091092
20MP0002938_white_spotting1.90371194
21MP0003567_abnormal_fetal_cardiomyocyte1.83834288
22MP0002736_abnormal_nociception_after1.80966489
23MP0008058_abnormal_DNA_repair1.78629368
24MP0003937_abnormal_limbs/digits/tail_de1.75434743
25MP0002233_abnormal_nose_morphology1.65321079
26MP0001485_abnormal_pinna_reflex1.64436461
27MP0003890_abnormal_embryonic-extraembry1.60314503
28MP0006072_abnormal_retinal_apoptosis1.60079909
29MP0004133_heterotaxia1.59034666
30MP0003941_abnormal_skin_development1.52698646
31MP0003880_abnormal_central_pattern1.49829862
32MP0003121_genomic_imprinting1.47676673
33MP0005551_abnormal_eye_electrophysiolog1.41133525
34MP0003111_abnormal_nucleus_morphology1.38697060
35MP0003123_paternal_imprinting1.35723360
36MP0003119_abnormal_digestive_system1.35474980
37MP0002697_abnormal_eye_size1.32250169
38MP0005253_abnormal_eye_physiology1.31698974
39MP0008932_abnormal_embryonic_tissue1.31071904
40MP0001286_abnormal_eye_development1.29944438
41MP0004957_abnormal_blastocyst_morpholog1.29264995
42MP0000647_abnormal_sebaceous_gland1.25020190
43MP0003186_abnormal_redox_activity1.24699947
44MP0000631_abnormal_neuroendocrine_gland1.23338606
45MP0000383_abnormal_hair_follicle1.21268630
46MP0001529_abnormal_vocalization1.19462672
47MP0000428_abnormal_craniofacial_morphol1.17313450
48MP0002638_abnormal_pupillary_reflex1.16978781
49MP0002751_abnormal_autonomic_nervous1.15156652
50MP0003938_abnormal_ear_development1.14363474
51MP0005391_vision/eye_phenotype1.14157077
52MP0000579_abnormal_nail_morphology1.08780098
53MP0003718_maternal_effect1.07176976
54MP0005248_abnormal_Harderian_gland1.06883682
55MP0001299_abnormal_eye_distance/1.05784948
56MP0002092_abnormal_eye_morphology1.05343643
57MP0000049_abnormal_middle_ear1.03740933
58MP0003077_abnormal_cell_cycle1.00956581
59MP0001764_abnormal_homeostasis1.00896000
60MP0000537_abnormal_urethra_morphology0.98005165
61MP0000778_abnormal_nervous_system0.97199583
62MP0001324_abnormal_eye_pigmentation0.95525082
63MP0003786_premature_aging0.94004934
64MP0002090_abnormal_vision0.91295929
65MP0000026_abnormal_inner_ear0.91052681
66MP0002084_abnormal_developmental_patter0.90730650
67MP0009379_abnormal_foot_pigmentation0.90440297
68MP0003755_abnormal_palate_morphology0.89483457
69MP0002282_abnormal_trachea_morphology0.88639790
70MP0001968_abnormal_touch/_nociception0.87985169
71MP0006276_abnormal_autonomic_nervous0.83384631
72MP0010678_abnormal_skin_adnexa0.81622222
73MP0001963_abnormal_hearing_physiology0.80771701
74MP0000427_abnormal_hair_cycle0.79633528
75MP0002085_abnormal_embryonic_tissue0.78876865
76MP0009780_abnormal_chondrocyte_physiolo0.78803782
77MP0002277_abnormal_respiratory_mucosa0.78761217
78MP0009672_abnormal_birth_weight0.78320379
79MP0003195_calcinosis0.78295954
80MP0002752_abnormal_somatic_nervous0.77027976
81MP0003861_abnormal_nervous_system0.76195555
82MP0000372_irregular_coat_pigmentation0.74907496
83MP0005195_abnormal_posterior_eye0.74871263
84MP0002111_abnormal_tail_morphology0.74525573
85MP0002557_abnormal_social/conspecific_i0.71343261
86MP0006054_spinal_hemorrhage0.70588100
87MP0001697_abnormal_embryo_size0.69857114
88MP0004019_abnormal_vitamin_homeostasis0.67845203
89MP0004197_abnormal_fetal_growth/weight/0.65767718
90MP0009703_decreased_birth_body0.64245366
91MP0005084_abnormal_gallbladder_morpholo0.64135323
92MP0001730_embryonic_growth_arrest0.63677032
93MP0006035_abnormal_mitochondrial_morpho0.63092678
94MP0000613_abnormal_salivary_gland0.62709010
95MP0005645_abnormal_hypothalamus_physiol0.62127238
96MP0002210_abnormal_sex_determination0.62073169
97MP0005647_abnormal_sex_gland0.61302054
98MP0008007_abnormal_cellular_replicative0.59847513
99MP0003942_abnormal_urinary_system0.59082159
100MP0001486_abnormal_startle_reflex0.58954766

Predicted human phenotypes

RankGene SetZ-score
1Septo-optic dysplasia (HP:0100842)5.30200660
2Intestinal atresia (HP:0011100)3.45965757
3Rib fusion (HP:0000902)3.20046333
4Colon cancer (HP:0003003)3.00639637
5Anophthalmia (HP:0000528)2.98058192
6Spastic diplegia (HP:0001264)2.98027441
7Chronic hepatic failure (HP:0100626)2.96292692
8Absent septum pellucidum (HP:0001331)2.93403809
9Hyperglycinemia (HP:0002154)2.86382797
10Gastrointestinal atresia (HP:0002589)2.78913428
11Esophageal atresia (HP:0002032)2.76545273
12Pancreatic fibrosis (HP:0100732)2.74895384
13Congenital primary aphakia (HP:0007707)2.73998225
14Maternal diabetes (HP:0009800)2.73071386
15True hermaphroditism (HP:0010459)2.70385267
16Gait imbalance (HP:0002141)2.66934123
17Abnormality of midbrain morphology (HP:0002418)2.65532308
18Molar tooth sign on MRI (HP:0002419)2.65532308
19Medial flaring of the eyebrow (HP:0010747)2.64090278
20Microvesicular hepatic steatosis (HP:0001414)2.62869402
21Hyperglycinuria (HP:0003108)2.62775320
22Occipital encephalocele (HP:0002085)2.56909679
23Abnormality of the labia minora (HP:0012880)2.55879045
24Abnormality of the septum pellucidum (HP:0007375)2.55355208
25Nephrogenic diabetes insipidus (HP:0009806)2.55077350
26Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.52838012
27Optic nerve hypoplasia (HP:0000609)2.52658102
28Genital tract atresia (HP:0001827)2.49431497
29Pancreatic cysts (HP:0001737)2.46482943
30Methylmalonic aciduria (HP:0012120)2.46184057
31Vaginal atresia (HP:0000148)2.42391300
32Abnormality of glycine metabolism (HP:0010895)2.41667117
33Abnormality of serine family amino acid metabolism (HP:0010894)2.41667117
34Broad foot (HP:0001769)2.38515348
35Acute encephalopathy (HP:0006846)2.34844897
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.34606060
37Abnormal lung lobation (HP:0002101)2.32694020
38Hemivertebrae (HP:0002937)2.30884873
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.28534490
40Short tibia (HP:0005736)2.26151373
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.22686094
42Abnormality of the parathyroid morphology (HP:0011766)2.19997560
43Bifid tongue (HP:0010297)2.19032883
44Nephronophthisis (HP:0000090)2.18454896
45Medulloblastoma (HP:0002885)2.18095050
46Postaxial foot polydactyly (HP:0001830)2.17647164
47Anencephaly (HP:0002323)2.17031141
48Bile duct proliferation (HP:0001408)2.16661988
49Abnormal biliary tract physiology (HP:0012439)2.16661988
50Methylmalonic acidemia (HP:0002912)2.10166640
51Preaxial hand polydactyly (HP:0001177)2.08382433
52Reticulocytopenia (HP:0001896)2.07734857
53Aqueductal stenosis (HP:0002410)2.06308029
54Intrahepatic cholestasis (HP:0001406)2.06041692
55Sclerocornea (HP:0000647)2.05318547
56Abnormal respiratory motile cilium physiology (HP:0012261)2.04645969
57Absent radius (HP:0003974)2.04408799
58Poor coordination (HP:0002370)2.02560337
59Oligodactyly (HP:0012165)2.02120269
60Acute necrotizing encephalopathy (HP:0006965)2.01902764
61Holoprosencephaly (HP:0001360)1.99730729
62Pancreatic islet-cell hyperplasia (HP:0004510)1.96353255
63Abnormality of serum amino acid levels (HP:0003112)1.95998791
64Agnosia (HP:0010524)1.95089520
65Rhinitis (HP:0012384)1.93341488
66Meckel diverticulum (HP:0002245)1.92790314
67Absent forearm bone (HP:0003953)1.92504437
68Aplasia involving forearm bones (HP:0009822)1.92504437
69Abnormality of the ileum (HP:0001549)1.91686291
70Growth hormone deficiency (HP:0000824)1.91325924
71Chronic bronchitis (HP:0004469)1.90601390
72Partial duplication of thumb phalanx (HP:0009944)1.84965067
73Postaxial hand polydactyly (HP:0001162)1.84575595
74Median cleft lip (HP:0000161)1.83641330
75Abnormal respiratory motile cilium morphology (HP:0005938)1.80980672
76Abnormal respiratory epithelium morphology (HP:0012253)1.80980672
77Oligodactyly (hands) (HP:0001180)1.80605526
78Exercise-induced muscle cramps (HP:0003710)1.79450592
79Multiple enchondromatosis (HP:0005701)1.79261062
80Renal hypoplasia (HP:0000089)1.77242680
81Abnormality of the aortic arch (HP:0012303)1.77074120
82Rhabdomyosarcoma (HP:0002859)1.76388481
83Increased CSF lactate (HP:0002490)1.76047130
84Ependymoma (HP:0002888)1.75721162
85Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.75669439
86Abnormality of glycolysis (HP:0004366)1.75084173
87Oculomotor apraxia (HP:0000657)1.75075372
88Ectopic kidney (HP:0000086)1.74020676
89Increased serum pyruvate (HP:0003542)1.73648516
90Cystic liver disease (HP:0006706)1.71155280
91Preaxial foot polydactyly (HP:0001841)1.70148541
92Hepatoblastoma (HP:0002884)1.68247145
93Abnormal mitochondria in muscle tissue (HP:0008316)1.67994351
94Chorioretinal coloboma (HP:0000567)1.67126455
95Abnormality of chromosome stability (HP:0003220)1.66025065
96Chromsome breakage (HP:0040012)1.64308604
97Facial hemangioma (HP:0000329)1.63301491
98Specific learning disability (HP:0001328)1.62657209
99Dandy-Walker malformation (HP:0001305)1.60242931
100Hypoglycemic seizures (HP:0002173)1.59962532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.89966238
2CDC73.41175932
3TNIK2.93910999
4WNK32.93351631
5SRPK12.70119679
6BMPR1B2.59642275
7BCKDK2.51623488
8ACVR1B2.48737393
9PBK2.28705205
10ZAK2.27376092
11EPHA42.22780886
12MAP2K72.21491559
13STK162.06912296
14CASK2.06398979
15TRIM282.03312072
16NUAK12.01919532
17MKNK22.00640417
18VRK21.96307340
19BUB11.84613249
20MST41.82809271
21DYRK31.82129125
22VRK11.75976424
23CDK191.75895348
24TTK1.74791647
25PDK21.69304601
26MKNK11.68542706
27PLK31.67790749
28ERBB41.52747409
29DYRK21.51819610
30GRK11.48303786
31CSNK1G11.47556463
32FRK1.45534337
33PRKD31.31608062
34RPS6KA41.29742769
35TNK21.29711430
36NME11.29599935
37PLK11.27824121
38WEE11.22046815
39CSNK1G31.13401603
40MAP3K101.12397664
41CSNK1A1L1.06470666
42NTRK31.05847599
43BCR1.03379984
44WNK41.03080791
45ATR0.97155015
46CSNK1G20.95155416
47PLK20.91564638
48STK38L0.91131386
49PINK10.84747692
50TAF10.82312207
51FGFR10.81698158
52MAP3K40.79620127
53TSSK60.79169716
54TGFBR10.79111217
55AURKB0.77326388
56NEK90.77146382
57PLK40.75020711
58CHEK20.73540368
59NEK20.69754918
60PRKCE0.66395544
61PNCK0.64230077
62ATM0.63657433
63FLT30.63173031
64TIE10.62340701
65AURKA0.59875559
66NLK0.59203969
67OBSCN0.59011418
68CSNK1A10.57395757
69OXSR10.57302288
70MAPK130.54655427
71ERBB30.52045718
72STK40.51714913
73PRKCG0.51522391
74CHEK10.50056127
75MINK10.49882581
76CSNK1E0.46337542
77BRSK20.46262220
78TLK10.43670985
79STK30.42311764
80CSNK2A10.42237944
81NEK10.41428002
82CDK70.40738440
83CDK10.39251131
84CSNK2A20.38323954
85FER0.37690895
86MAP2K40.37623606
87RPS6KA50.37514446
88PRKDC0.36808619
89INSRR0.35241829
90EIF2AK20.35138004
91DYRK1A0.32795340
92CAMK2A0.32237433
93FGFR20.31912962
94PRKACB0.30283364
95PRKCZ0.29279329
96CDK20.28406555
97SGK4940.28172504
98SGK2230.28172504
99STK380.28042198
100CAMK2D0.27531684

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.02564920
2Mismatch repair_Homo sapiens_hsa034302.71496704
3Steroid biosynthesis_Homo sapiens_hsa001002.47074523
4Propanoate metabolism_Homo sapiens_hsa006402.40383090
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31708265
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.30801060
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.24110909
8DNA replication_Homo sapiens_hsa030302.16177283
9Homologous recombination_Homo sapiens_hsa034402.14956582
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06307581
11RNA polymerase_Homo sapiens_hsa030202.00984648
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.94863016
13Protein export_Homo sapiens_hsa030601.87625451
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81671378
15Fanconi anemia pathway_Homo sapiens_hsa034601.75449610
16Butanoate metabolism_Homo sapiens_hsa006501.73849913
17Non-homologous end-joining_Homo sapiens_hsa034501.71249596
18Oxidative phosphorylation_Homo sapiens_hsa001901.70128824
19Proteasome_Homo sapiens_hsa030501.64578793
20RNA degradation_Homo sapiens_hsa030181.59280006
21Vitamin B6 metabolism_Homo sapiens_hsa007501.54258962
22Biosynthesis of amino acids_Homo sapiens_hsa012301.51082133
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50686629
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.49937174
25Base excision repair_Homo sapiens_hsa034101.47162455
26Parkinsons disease_Homo sapiens_hsa050121.46367119
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.45475917
28Fatty acid elongation_Homo sapiens_hsa000621.43905514
29Glutathione metabolism_Homo sapiens_hsa004801.39551684
30Spliceosome_Homo sapiens_hsa030401.38888059
31Ribosome_Homo sapiens_hsa030101.38340426
32Pyruvate metabolism_Homo sapiens_hsa006201.37640382
33Nucleotide excision repair_Homo sapiens_hsa034201.32176197
34Huntingtons disease_Homo sapiens_hsa050161.32108480
35RNA transport_Homo sapiens_hsa030131.31411035
36Basal cell carcinoma_Homo sapiens_hsa052171.29981096
37Selenocompound metabolism_Homo sapiens_hsa004501.29907974
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29870633
39Basal transcription factors_Homo sapiens_hsa030221.25640681
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22469738
41Fatty acid degradation_Homo sapiens_hsa000711.20261202
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20113064
43Carbon metabolism_Homo sapiens_hsa012001.18890548
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16783505
45Pyrimidine metabolism_Homo sapiens_hsa002401.12732913
46Tryptophan metabolism_Homo sapiens_hsa003801.11821870
47Peroxisome_Homo sapiens_hsa041461.10412933
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07051500
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04467290
50Alzheimers disease_Homo sapiens_hsa050101.02624084
51Fatty acid metabolism_Homo sapiens_hsa012121.01744137
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.99086027
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96346091
54Retinol metabolism_Homo sapiens_hsa008300.96325925
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96116306
56Vitamin digestion and absorption_Homo sapiens_hsa049770.94854087
57Caffeine metabolism_Homo sapiens_hsa002320.91924523
58Phototransduction_Homo sapiens_hsa047440.90242814
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89379590
60Purine metabolism_Homo sapiens_hsa002300.87556049
61Fat digestion and absorption_Homo sapiens_hsa049750.86347541
62One carbon pool by folate_Homo sapiens_hsa006700.85843107
63Folate biosynthesis_Homo sapiens_hsa007900.85760806
64beta-Alanine metabolism_Homo sapiens_hsa004100.84925779
65Metabolic pathways_Homo sapiens_hsa011000.82876367
66Arginine and proline metabolism_Homo sapiens_hsa003300.82686432
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81804177
68Chemical carcinogenesis_Homo sapiens_hsa052040.79771442
69Cardiac muscle contraction_Homo sapiens_hsa042600.79498206
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79319042
71Nitrogen metabolism_Homo sapiens_hsa009100.73810316
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.73260753
73Cell cycle_Homo sapiens_hsa041100.71854909
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.71488444
75Hedgehog signaling pathway_Homo sapiens_hsa043400.68820411
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67386081
77Taste transduction_Homo sapiens_hsa047420.66718815
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.66162671
79Lysine degradation_Homo sapiens_hsa003100.65987056
80Sulfur relay system_Homo sapiens_hsa041220.65333515
81mRNA surveillance pathway_Homo sapiens_hsa030150.64206588
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64164057
83Hippo signaling pathway_Homo sapiens_hsa043900.63401914
84Nicotine addiction_Homo sapiens_hsa050330.61384438
85Pentose phosphate pathway_Homo sapiens_hsa000300.61018964
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60669253
87Linoleic acid metabolism_Homo sapiens_hsa005910.56774027
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55449699
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50526311
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48709203
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47356076
92Regulation of autophagy_Homo sapiens_hsa041400.47166942
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44743038
94PPAR signaling pathway_Homo sapiens_hsa033200.40519105
95TGF-beta signaling pathway_Homo sapiens_hsa043500.40451983
96Arginine biosynthesis_Homo sapiens_hsa002200.35352777
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35252260
98* Wnt signaling pathway_Homo sapiens_hsa043100.34316755
99Tight junction_Homo sapiens_hsa045300.33813029
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.32889903

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