TBL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1peptidyl-arginine omega-N-methylation (GO:0035247)5.97737208
2GDP-mannose metabolic process (GO:0019673)5.51628570
3peptidyl-arginine methylation (GO:0018216)4.90868036
4peptidyl-arginine N-methylation (GO:0035246)4.90868036
5proline biosynthetic process (GO:0006561)4.90275949
6nucleobase biosynthetic process (GO:0046112)4.83507421
7histone arginine methylation (GO:0034969)4.80313969
8DNA strand elongation involved in DNA replication (GO:0006271)4.77626604
9DNA deamination (GO:0045006)4.73239652
10purine nucleobase biosynthetic process (GO:0009113)4.66615032
11maturation of SSU-rRNA (GO:0030490)4.62671336
12DNA replication initiation (GO:0006270)4.62066248
13DNA strand elongation (GO:0022616)4.56262356
14DNA replication checkpoint (GO:0000076)4.50387190
15telomere maintenance via semi-conservative replication (GO:0032201)4.38599785
16ribosomal small subunit assembly (GO:0000028)4.37698495
17DNA unwinding involved in DNA replication (GO:0006268)4.32012708
18formation of translation preinitiation complex (GO:0001731)4.30752182
19COPI coating of Golgi vesicle (GO:0048205)4.30663487
20Golgi transport vesicle coating (GO:0048200)4.30663487
21mitotic metaphase plate congression (GO:0007080)4.29805221
22ribosomal large subunit biogenesis (GO:0042273)4.29754322
23ribosome biogenesis (GO:0042254)4.24029969
24protein localization to kinetochore (GO:0034501)4.22200099
25regulation of translational fidelity (GO:0006450)4.21306318
26ribonucleoprotein complex biogenesis (GO:0022613)4.10592906
27ribosome assembly (GO:0042255)4.03068890
28spliceosomal tri-snRNP complex assembly (GO:0000244)3.92053331
29IMP biosynthetic process (GO:0006188)3.88721771
30telomere maintenance via recombination (GO:0000722)3.86186668
31spliceosomal snRNP assembly (GO:0000387)3.84087067
32ribosomal small subunit biogenesis (GO:0042274)3.82039701
33viral transcription (GO:0019083)3.80931286
34UV protection (GO:0009650)3.79331633
35folic acid-containing compound biosynthetic process (GO:0009396)3.78402632
36translational termination (GO:0006415)3.78213115
37CENP-A containing nucleosome assembly (GO:0034080)3.77163495
38chromatin remodeling at centromere (GO:0031055)3.75190178
39mitotic nuclear envelope disassembly (GO:0007077)3.71465706
40* rRNA processing (GO:0006364)3.71341528
41mitotic recombination (GO:0006312)3.68214004
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.67463323
43metaphase plate congression (GO:0051310)3.63738137
44DNA replication-dependent nucleosome assembly (GO:0006335)3.63196270
45DNA replication-dependent nucleosome organization (GO:0034723)3.63196270
46nuclear envelope reassembly (GO:0031468)3.62345807
47mitotic nuclear envelope reassembly (GO:0007084)3.62345807
48telomere maintenance via telomere lengthening (GO:0010833)3.61578526
49protein retention in ER lumen (GO:0006621)3.60387377
50* rRNA metabolic process (GO:0016072)3.59403310
51translational initiation (GO:0006413)3.58172188
52pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.57216953
53protein localization to chromosome, centromeric region (GO:0071459)3.53998177
54regulation of mammary gland epithelial cell proliferation (GO:0033599)3.48364548
55translational elongation (GO:0006414)3.47821012
56folic acid metabolic process (GO:0046655)3.45876683
57maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.44563003
58DNA replication-independent nucleosome organization (GO:0034724)3.44490177
59DNA replication-independent nucleosome assembly (GO:0006336)3.44490177
60regulation of translational termination (GO:0006449)3.41397046
61iron-sulfur cluster assembly (GO:0016226)3.41103854
62metallo-sulfur cluster assembly (GO:0031163)3.41103854
63pseudouridine synthesis (GO:0001522)3.40725168
64transcription elongation from RNA polymerase III promoter (GO:0006385)3.40638056
65termination of RNA polymerase III transcription (GO:0006386)3.40638056
66nuclear envelope disassembly (GO:0051081)3.40214458
67membrane disassembly (GO:0030397)3.40214458
68adenine nucleotide transport (GO:0051503)3.39895965
69nucleotide-excision repair, DNA gap filling (GO:0006297)3.37708162
70nuclear pore organization (GO:0006999)3.35448159
71rRNA modification (GO:0000154)3.35233643
72mitotic chromosome condensation (GO:0007076)3.31093540
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.31020958
74proline metabolic process (GO:0006560)3.30820898
75IMP metabolic process (GO:0046040)3.30151048
76negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.29224961
77nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.27492726
78regulation of nuclear cell cycle DNA replication (GO:0033262)3.27000407
79proteasome assembly (GO:0043248)3.25326731
80pentose-phosphate shunt (GO:0006098)3.24926542
81transcription-coupled nucleotide-excision repair (GO:0006283)3.21682228
82spliceosomal complex assembly (GO:0000245)3.15718992
83regulation of spindle organization (GO:0090224)3.13839115
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.13141594
85kinetochore organization (GO:0051383)3.13103437
86establishment of chromosome localization (GO:0051303)3.12799194
87mitotic sister chromatid segregation (GO:0000070)3.12667784
88SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12031556
89peptidyl-arginine modification (GO:0018195)3.11686913
90viral mRNA export from host cell nucleus (GO:0046784)3.10716542
91histone exchange (GO:0043486)3.10665842
92regulation of double-strand break repair via homologous recombination (GO:0010569)3.10265628
93kinetochore assembly (GO:0051382)3.10160131
94maturation of 5.8S rRNA (GO:0000460)3.09758046
95L-serine metabolic process (GO:0006563)3.09101165
96rRNA transcription (GO:0009303)3.07737653
97cellular component biogenesis (GO:0044085)3.07628581
98purine ribonucleotide transport (GO:0015868)3.07541947
99negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.06916490
100retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.06838958
101termination of RNA polymerase I transcription (GO:0006363)3.06599550
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06536354
103negative regulation of cell size (GO:0045792)3.05301170
104cellular protein complex disassembly (GO:0043624)3.03680897
105transcription elongation from RNA polymerase I promoter (GO:0006362)3.03580762
106transcription from RNA polymerase I promoter (GO:0006360)3.02732209
107DNA duplex unwinding (GO:0032508)3.02508413
108negative regulation of chromosome segregation (GO:0051985)3.02267694
109cotranslational protein targeting to membrane (GO:0006613)3.01825415
110attachment of spindle microtubules to kinetochore (GO:0008608)3.01309727
111protein targeting to ER (GO:0045047)3.01282939
112DNA geometric change (GO:0032392)3.00511901
113tRNA methylation (GO:0030488)3.00401496
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.99596730
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99596730
116negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.99596730
117negative regulation of sister chromatid segregation (GO:0033046)2.99596730
118rRNA methylation (GO:0031167)2.99145194
119positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.98661185
120chromosome condensation (GO:0030261)2.98277778
121spindle checkpoint (GO:0031577)2.97411000
122regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.96969237
123spindle assembly checkpoint (GO:0071173)2.96528364
124regulation of mitochondrial translation (GO:0070129)2.96460797
125translation (GO:0006412)2.95124908
126mitotic spindle assembly checkpoint (GO:0007094)2.95058417
127viral life cycle (GO:0019058)2.94715151
128snRNA metabolic process (GO:0016073)2.94534664
1297-methylguanosine mRNA capping (GO:0006370)2.94120081
130nuclear pore complex assembly (GO:0051292)2.92348687
131* ncRNA processing (GO:0034470)2.91520043
132negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90001817
133RNA splicing, via transesterification reactions (GO:0000375)2.89828059
134negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89434693
135mitotic spindle checkpoint (GO:0071174)2.89086346
136pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.89057631
137mRNA splicing, via spliceosome (GO:0000398)2.88606053
138pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.88314012
139pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.87855336
140glucose catabolic process (GO:0006007)2.86738762
141pyrimidine nucleotide catabolic process (GO:0006244)2.85120664
142intracellular estrogen receptor signaling pathway (GO:0030520)2.84857393
143protein insertion into membrane (GO:0051205)2.82128064
144guanosine-containing compound biosynthetic process (GO:1901070)2.81090941
145establishment of viral latency (GO:0019043)2.80830502
146NADPH regeneration (GO:0006740)2.79759190
147nucleosome disassembly (GO:0006337)2.79479879
148protein-DNA complex disassembly (GO:0032986)2.79479879
149nucleobase-containing small molecule interconversion (GO:0015949)2.77659110
150tRNA modification (GO:0006400)2.75640934
151pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.72898183
152apoptotic process involved in morphogenesis (GO:0060561)2.72276895
153pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.70941385
154pentose metabolic process (GO:0019321)2.70128817
155snRNA processing (GO:0016180)2.69158554
156positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.68933957
157heterochromatin organization (GO:0070828)2.68298102
158UTP biosynthetic process (GO:0006228)2.67932606
159purine nucleotide transport (GO:0015865)2.66584850
160DNA conformation change (GO:0071103)2.66454564
161base-excision repair (GO:0006284)2.65365209
162nuclear envelope organization (GO:0006998)2.64882886
163protein complex localization (GO:0031503)2.64866408
164mitochondrial fusion (GO:0008053)2.64510781
165DNA strand renaturation (GO:0000733)2.63550882
166chromatin assembly (GO:0031497)2.61051517
167base-excision repair, AP site formation (GO:0006285)2.59369983
168negative regulation of mRNA processing (GO:0050686)2.59041760
169DNA packaging (GO:0006323)2.57805868
170negative regulation of DNA-templated transcription, elongation (GO:0032785)2.56806899
171glucose 6-phosphate metabolic process (GO:0051156)2.56736782
172tRNA aminoacylation for protein translation (GO:0006418)2.56678915
173pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.55822392

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.23914859
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.51358269
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66980272
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.60209151
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48075879
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25718797
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.21160335
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14114385
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02784815
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.02094104
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00662060
12* ETS1_20019798_ChIP-Seq_JURKAT_Human3.00076385
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.95156559
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.85580257
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68545787
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55097908
17XRN2_22483619_ChIP-Seq_HELA_Human2.48777442
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.39902126
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.36088650
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32844640
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30716929
22LXR_22292898_ChIP-Seq_THP-1_Human2.29021590
23* VDR_23849224_ChIP-Seq_CD4+_Human2.20429294
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16708821
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15090183
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.08110225
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.05674751
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04435972
29* DCP1A_22483619_ChIP-Seq_HELA_Human2.04193747
30FOXP3_21729870_ChIP-Seq_TREG_Human2.03997645
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96604141
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92863242
33TTF2_22483619_ChIP-Seq_HELA_Human1.92039123
34GABP_19822575_ChIP-Seq_HepG2_Human1.91797066
35AR_21909140_ChIP-Seq_LNCAP_Human1.90809008
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.89292306
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88937061
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86765884
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86518882
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84284674
41P68_20966046_ChIP-Seq_HELA_Human1.83834113
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80957512
43* ELK3_25401928_ChIP-Seq_HUVEC_Human1.78360664
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.77222247
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.74264741
46RACK7_27058665_Chip-Seq_MCF-7_Human1.67547107
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65990141
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62448462
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61829120
50* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59576027
51ZNF263_19887448_ChIP-Seq_K562_Human1.59258029
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58620218
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56624716
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56264915
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56098382
56* CIITA_25753668_ChIP-Seq_RAJI_Human1.55509063
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53373501
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51796626
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51624017
60MYC_22102868_ChIP-Seq_BL_Human1.49027156
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.47689786
62MAF_26560356_Chip-Seq_TH2_Human1.43410882
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42874437
64* SRF_21415370_ChIP-Seq_HL-1_Mouse1.42259806
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42151869
66KDM5A_27292631_Chip-Seq_BREAST_Human1.41611142
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.40271818
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39209250
69* SA1_27219007_Chip-Seq_ERYTHROID_Human1.38579398
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.37711332
71ELK1_19687146_ChIP-ChIP_HELA_Human1.37666022
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.36138763
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35940754
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35883111
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34945881
76BCOR_27268052_Chip-Seq_Bcells_Human1.34911316
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34313771
78BCL6_27268052_Chip-Seq_Bcells_Human1.33534521
79TP63_17297297_ChIP-ChIP_HaCaT_Human1.33386860
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33367672
81KDM2B_26808549_Chip-Seq_DND41_Human1.32776113
82MAF_26560356_Chip-Seq_TH1_Human1.32534399
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.32473673
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30062566
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28541433
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27773881
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25178944
88* FOXP1_21924763_ChIP-Seq_HESCs_Human1.24411916
89SMC4_20622854_ChIP-Seq_HELA_Human1.24139931
90TCF7_22412390_ChIP-Seq_EML_Mouse1.23794195
91PHF8_20622854_ChIP-Seq_HELA_Human1.23369925
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21804850
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21416101
94ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20344308
95* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20019384
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19309212
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18223301
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16720842
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16378264
100CTCF_21964334_Chip-Seq_Bcells_Human1.15964329
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14623380
102RARA_24833708_ChIP-Seq_LIVER_Mouse1.14448059
103* NCOR1_26117541_ChIP-Seq_K562_Human1.14392797
104SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13910520
105E2F1_20622854_ChIP-Seq_HELA_Human1.13297259
106* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12594865
107UTX_26944678_Chip-Seq_JUKART_Human1.11300203
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10090435
109* ATF3_27146783_Chip-Seq_COLON_Human1.09805944
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09548412
111* CTCF_26484167_Chip-Seq_Bcells_Mouse1.09387287
112* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08246149
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08113649
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07939371
115CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05802428
116* RARB_24833708_ChIP-Seq_LIVER_Mouse1.05170479
117SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05091491
118* ETS1_21867929_ChIP-Seq_TH2_Mouse1.04574590
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04325626
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03434875
121TFEB_21752829_ChIP-Seq_HELA_Human1.03426913
122VDR_24763502_ChIP-Seq_THP-1_Human1.01867902
123PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01360144
124TP53_22127205_ChIP-Seq_IMR90_Human1.01089634
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00390688
126* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98351800
127* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97523667
128MYC_18940864_ChIP-ChIP_HL60_Human0.97399653
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97379076
130* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92241245
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91772124
132VDR_21846776_ChIP-Seq_THP-1_Human0.90111595
133SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89087859
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.88251227
135* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85974117
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85718945
137KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85717093
138KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85717093
139KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85717093
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83568077
141TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81964144
142TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78803167
143SPI1_23547873_ChIP-Seq_NB4_Human0.78506829
144OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78274503
145CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.77511515
146NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77376751
147SOX2_18692474_ChIP-Seq_MEFs_Mouse0.77290413
148HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77138281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.83268355
2MP0003111_abnormal_nucleus_morphology4.75998014
3MP0010094_abnormal_chromosome_stability4.62134228
4MP0004957_abnormal_blastocyst_morpholog4.61270707
5MP0003077_abnormal_cell_cycle4.03665038
6MP0008057_abnormal_DNA_replication3.74824584
7MP0008058_abnormal_DNA_repair3.53916945
8MP0005451_abnormal_body_composition3.47572774
9MP0008007_abnormal_cellular_replicative3.02048778
10MP0008932_abnormal_embryonic_tissue2.89497628
11MP0003705_abnormal_hypodermis_morpholog2.54858308
12MP0003786_premature_aging2.47711225
13MP0001730_embryonic_growth_arrest2.39963529
14MP0003123_paternal_imprinting2.38700393
15MP0002396_abnormal_hematopoietic_system2.37216145
16MP0000678_abnormal_parathyroid_gland2.35503077
17MP0000350_abnormal_cell_proliferation2.26197240
18MP0005058_abnormal_lysosome_morphology2.18165977
19MP0005501_abnormal_skin_physiology2.13881787
20MP0005171_absent_coat_pigmentation2.09767933
21MP0010030_abnormal_orbit_morphology2.02830462
22MP0010234_abnormal_vibrissa_follicle2.00569920
23MP0004233_abnormal_muscle_weight1.92158025
24MP0003718_maternal_effect1.91470329
25MP0001849_ear_inflammation1.87899501
26MP0000751_myopathy1.87536580
27MP0000490_abnormal_crypts_of1.87016653
28MP0005380_embryogenesis_phenotype1.85693597
29MP0001672_abnormal_embryogenesis/_devel1.85693597
30MP0002796_impaired_skin_barrier1.82330916
31MP0003453_abnormal_keratinocyte_physiol1.78842682
32MP0008877_abnormal_DNA_methylation1.75279391
33MP0004185_abnormal_adipocyte_glucose1.72730206
34MP0001697_abnormal_embryo_size1.71564787
35MP0000003_abnormal_adipose_tissue1.68546031
36MP0004858_abnormal_nervous_system1.68120861
37MP0002080_prenatal_lethality1.65863646
38MP0002085_abnormal_embryonic_tissue1.62132625
39MP0003984_embryonic_growth_retardation1.62058554
40MP0002877_abnormal_melanocyte_morpholog1.58829990
41MP0001661_extended_life_span1.58159120
42MP0002088_abnormal_embryonic_growth/wei1.57676821
43MP0000313_abnormal_cell_death1.53951049
44MP0010307_abnormal_tumor_latency1.51639914
45MP0009333_abnormal_splenocyte_physiolog1.47231375
46MP0010352_gastrointestinal_tract_polyps1.43965500
47MP0001873_stomach_inflammation1.42820881
48MP0002653_abnormal_ependyma_morphology1.41058194
49MP0002084_abnormal_developmental_patter1.37059874
50MP0006292_abnormal_olfactory_placode1.36920041
51MP0002019_abnormal_tumor_incidence1.33494880
52MP0000750_abnormal_muscle_regeneration1.33302359
53MP0002102_abnormal_ear_morphology1.32548304
54MP0001293_anophthalmia1.32435103
55MP0002249_abnormal_larynx_morphology1.31686558
56MP0009840_abnormal_foam_cell1.29480572
57MP0002086_abnormal_extraembryonic_tissu1.29414944
58MP0004808_abnormal_hematopoietic_stem1.28475642
59MP0002132_abnormal_respiratory_system1.26695329
60MP0002210_abnormal_sex_determination1.26331358
61MP0003315_abnormal_perineum_morphology1.22508907
62MP0004197_abnormal_fetal_growth/weight/1.21227146
63MP0001348_abnormal_lacrimal_gland1.19197755
64MP0009379_abnormal_foot_pigmentation1.14499890
65MP0003567_abnormal_fetal_cardiomyocyte1.14253268
66MP0005375_adipose_tissue_phenotype1.13647247
67MP0001216_abnormal_epidermal_layer1.13628461
68MP0001145_abnormal_male_reproductive1.12891123
69MP0003119_abnormal_digestive_system1.11391775
70MP0005623_abnormal_meninges_morphology1.10936579
71MP0003806_abnormal_nucleotide_metabolis1.10888493
72MP0005083_abnormal_biliary_tract1.09482107
73MP0002160_abnormal_reproductive_system1.09397487
74MP0005666_abnormal_adipose_tissue1.08953796
75MP0003566_abnormal_cell_adhesion1.08745040
76MP0003890_abnormal_embryonic-extraembry1.08299407
77MP0002098_abnormal_vibrissa_morphology1.07482736
78MP0005410_abnormal_fertilization1.07365564
79MP0000747_muscle_weakness1.06645308
80MP0009931_abnormal_skin_appearance1.06408295
81MP0005330_cardiomyopathy1.05966085
82MP0002089_abnormal_postnatal_growth/wei1.04037369
83MP0003763_abnormal_thymus_physiology1.03770222
84MP0001545_abnormal_hematopoietic_system1.01614222
85MP0005397_hematopoietic_system_phenotyp1.01614222
86MP0000703_abnormal_thymus_morphology1.00887571
87MP0000467_abnormal_esophagus_morphology0.99768362
88MP0003121_genomic_imprinting0.96700941
89MP0006036_abnormal_mitochondrial_physio0.95701512
90MP0004133_heterotaxia0.95636865
91MP0001929_abnormal_gametogenesis0.94167355
92MP0003136_yellow_coat_color0.93255484
93MP0003941_abnormal_skin_development0.92300135
94MP0000653_abnormal_sex_gland0.91723752
95MP0006035_abnormal_mitochondrial_morpho0.90164408
96MP0002722_abnormal_immune_system0.89831820
97MP0002111_abnormal_tail_morphology0.89685318
98MP0000759_abnormal_skeletal_muscle0.89094076
99MP0000566_synostosis0.89060493
100MP0001346_abnormal_lacrimal_gland0.88832900
101MP0000358_abnormal_cell_content/0.88598266
102MP0005499_abnormal_olfactory_system0.87899963
103MP0005394_taste/olfaction_phenotype0.87899963
104MP0001881_abnormal_mammary_gland0.87551698
105MP0000013_abnormal_adipose_tissue0.87498411
106MP0002060_abnormal_skin_morphology0.86933418
107MP0008260_abnormal_autophagy0.86296682
108MP0002398_abnormal_bone_marrow0.85069855
109MP0001188_hyperpigmentation0.85047695
110MP0000537_abnormal_urethra_morphology0.84518105
111MP0002938_white_spotting0.83917201
112MP0000689_abnormal_spleen_morphology0.83915353
113MP0008995_early_reproductive_senescence0.81824253
114MP0005389_reproductive_system_phenotype0.80876727
115MP0009672_abnormal_birth_weight0.78898206
116MP0005075_abnormal_melanosome_morpholog0.77943893
117MP0000858_altered_metastatic_potential0.77537861
118MP0010771_integument_phenotype0.77327865
119MP0004947_skin_inflammation0.76587128
120MP0002254_reproductive_system_inflammat0.76175105
121MP0005423_abnormal_somatic_nervous0.75985802
122MP0003186_abnormal_redox_activity0.75274603
123MP0005174_abnormal_tail_pigmentation0.74638215
124MP0005384_cellular_phenotype0.74558175
125MP0000428_abnormal_craniofacial_morphol0.74416443
126MP0005076_abnormal_cell_differentiation0.73610215
127MP0003937_abnormal_limbs/digits/tail_de0.72028264
128MP0001119_abnormal_female_reproductive0.71921105
129MP0000685_abnormal_immune_system0.70836848
130MP0002092_abnormal_eye_morphology0.70828446
131MP0005377_hearing/vestibular/ear_phenot0.70813424
132MP0003878_abnormal_ear_physiology0.70813424
133MP0002429_abnormal_blood_cell0.69503984
134MP0005621_abnormal_cell_physiology0.68704597
135MP0001986_abnormal_taste_sensitivity0.68302383
136MP0009053_abnormal_anal_canal0.67983225
137MP0005584_abnormal_enzyme/coenzyme_acti0.67390099
138MP0001915_intracranial_hemorrhage0.67352916
139MP0000015_abnormal_ear_pigmentation0.67282207
140MP0001243_abnormal_dermal_layer0.67219075
141MP0001286_abnormal_eye_development0.66905960
142MP0002751_abnormal_autonomic_nervous0.66811286
143MP0002095_abnormal_skin_pigmentation0.66012053
144MP0004381_abnormal_hair_follicle0.65493104
145MP0002075_abnormal_coat/hair_pigmentati0.64574239
146MP0008789_abnormal_olfactory_epithelium0.64349771
147MP0001919_abnormal_reproductive_system0.63359086
148MP0003938_abnormal_ear_development0.62987148
149MP0003221_abnormal_cardiomyocyte_apopto0.62563090
150MP0000049_abnormal_middle_ear0.62149475
151MP0000477_abnormal_intestine_morphology0.61798938
152MP0001727_abnormal_embryo_implantation0.61351310
153MP0009278_abnormal_bone_marrow0.59568892

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.86399027
2Reticulocytopenia (HP:0001896)4.85051621
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.24873437
4Breast hypoplasia (HP:0003187)4.10896171
5Abnormality of cells of the erythroid lineage (HP:0012130)4.03378864
6Chromsome breakage (HP:0040012)4.03017671
7Hyperacusis (HP:0010780)3.93911442
8Abnormal number of erythroid precursors (HP:0012131)3.93151870
9Ulnar bowing (HP:0003031)3.80969372
10Cerebral hypomyelination (HP:0006808)3.68449125
11Rough bone trabeculation (HP:0100670)3.66498061
12Testicular atrophy (HP:0000029)3.60873924
13Oral leukoplakia (HP:0002745)3.54132760
14Selective tooth agenesis (HP:0001592)3.51493847
15Abnormality of the preputium (HP:0100587)3.39416968
16Poikiloderma (HP:0001029)3.38394608
17Patellar aplasia (HP:0006443)3.36324457
18Myopathic facies (HP:0002058)3.34834030
19Cholecystitis (HP:0001082)3.29302608
20Abnormal gallbladder physiology (HP:0012438)3.29302608
21Meckel diverticulum (HP:0002245)3.27977267
22Impulsivity (HP:0100710)3.25827985
23Abnormality of the ileum (HP:0001549)3.23609487
24Aplasia/Hypoplasia of the patella (HP:0006498)3.21585076
25Trismus (HP:0000211)3.21267387
26Absent thumb (HP:0009777)3.09962934
27Ragged-red muscle fibers (HP:0003200)3.04753031
28Abnormality of the anterior horn cell (HP:0006802)3.04237999
29Degeneration of anterior horn cells (HP:0002398)3.04237999
30Absent radius (HP:0003974)2.97836892
31Microretrognathia (HP:0000308)2.97745813
32Macrocytic anemia (HP:0001972)2.97340069
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.96831405
34Insomnia (HP:0100785)2.96659535
35Abnormality of chromosome stability (HP:0003220)2.94872238
36Colon cancer (HP:0003003)2.94591236
37Carpal bone hypoplasia (HP:0001498)2.93870420
38Pallor (HP:0000980)2.83490447
39Aplasia involving forearm bones (HP:0009822)2.80418957
40Absent forearm bone (HP:0003953)2.80418957
4111 pairs of ribs (HP:0000878)2.74858551
42Premature graying of hair (HP:0002216)2.73495778
43Ependymoma (HP:0002888)2.71920376
44Duplicated collecting system (HP:0000081)2.68717978
45Bone marrow hypocellularity (HP:0005528)2.66567265
46Broad distal phalanx of finger (HP:0009836)2.66408290
47Distal upper limb amyotrophy (HP:0007149)2.65304196
48Upper limb amyotrophy (HP:0009129)2.65304196
49Distal lower limb amyotrophy (HP:0008944)2.64071623
50Abnormal number of incisors (HP:0011064)2.63711459
51Abnormal trabecular bone morphology (HP:0100671)2.62618229
52Vaginal fistula (HP:0004320)2.62318796
53Medulloblastoma (HP:0002885)2.61754763
54Duodenal stenosis (HP:0100867)2.61523626
55Small intestinal stenosis (HP:0012848)2.61523626
56Neoplasm of the pancreas (HP:0002894)2.58905780
57Aplastic anemia (HP:0001915)2.57545466
58Achilles tendon contracture (HP:0001771)2.55048148
59Horseshoe kidney (HP:0000085)2.52902808
60Triphalangeal thumb (HP:0001199)2.51268737
61Reticulocytosis (HP:0001923)2.49599190
62Premature ovarian failure (HP:0008209)2.49396464
63Myelodysplasia (HP:0002863)2.48486402
64Abnormality of the renal collecting system (HP:0004742)2.40294448
65Secondary amenorrhea (HP:0000869)2.38759158
66Cholelithiasis (HP:0001081)2.38514411
67Tracheoesophageal fistula (HP:0002575)2.37985633
68Long palpebral fissure (HP:0000637)2.33579082
69Centrally nucleated skeletal muscle fibers (HP:0003687)2.33335820
70Vertebral compression fractures (HP:0002953)2.33003061
71Thin bony cortex (HP:0002753)2.31598385
72Ureteral duplication (HP:0000073)2.28984490
73Abnormal lung lobation (HP:0002101)2.27755429
74Cellular immunodeficiency (HP:0005374)2.27300255
75Annular pancreas (HP:0001734)2.26499604
76Hypoplasia of the radius (HP:0002984)2.21785831
77Abnormality of pyrimidine metabolism (HP:0004353)2.20963342
78Intestinal fistula (HP:0100819)2.19786901
79Progressive muscle weakness (HP:0003323)2.19417727
80Abnormality of the carotid arteries (HP:0005344)2.18812682
81Sloping forehead (HP:0000340)2.18344197
82Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18070864
83Short thumb (HP:0009778)2.16606320
84Rectal fistula (HP:0100590)2.16174307
85Rectovaginal fistula (HP:0000143)2.16174307
86Abnormality of the duodenum (HP:0002246)2.15140017
87Multiple enchondromatosis (HP:0005701)2.14234240
88Ectopic kidney (HP:0000086)2.14146522
89Distal lower limb muscle weakness (HP:0009053)2.14139147
90Hypertensive crisis (HP:0100735)2.13524110
91Turricephaly (HP:0000262)2.13208100
92Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.12370466
93Abnormality of the Achilles tendon (HP:0005109)2.12084226
94Reduced antithrombin III activity (HP:0001976)2.10286679
95Atresia of the external auditory canal (HP:0000413)2.09675788
96Agnosia (HP:0010524)2.09304600
97Pancytopenia (HP:0001876)2.09243078
98Basal cell carcinoma (HP:0002671)2.08117359
99Squamous cell carcinoma (HP:0002860)2.08100632
100Rhabdomyosarcoma (HP:0002859)2.06007845
101Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05983160
102Stridor (HP:0010307)2.05737811
103Sparse eyelashes (HP:0000653)2.03650409
104Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.03571209
105Absent epiphyses (HP:0010577)2.03571209
106Abnormality of DNA repair (HP:0003254)2.02930812
107Hand muscle atrophy (HP:0009130)2.02191858
108Rib fusion (HP:0000902)2.01716201
109Supernumerary spleens (HP:0009799)2.01491755
110Facial hemangioma (HP:0000329)2.01068923
111Cleft eyelid (HP:0000625)2.00974751
112Generalized amyotrophy (HP:0003700)2.00869194
113Abnormalities of placenta or umbilical cord (HP:0001194)2.00585188
114Microvesicular hepatic steatosis (HP:0001414)2.00414792
115Progressive external ophthalmoplegia (HP:0000590)2.00298962
116Proximal placement of thumb (HP:0009623)1.99546662
117Pointed chin (HP:0000307)1.99082513
118Nonimmune hydrops fetalis (HP:0001790)1.98870274
119Pterygium (HP:0001059)1.96755968
120Difficulty climbing stairs (HP:0003551)1.96035660
121Megaloblastic anemia (HP:0001889)1.95629275
122Increased connective tissue (HP:0009025)1.92192541
123Abnormal gallbladder morphology (HP:0012437)1.91380019
124Duplication of thumb phalanx (HP:0009942)1.89727119
125Abdominal situs inversus (HP:0003363)1.89456234
126Abnormality of abdominal situs (HP:0011620)1.89456234
127Hypokinesia (HP:0002375)1.88591076
128Bowed forearm bones (HP:0003956)1.87917079
129Bowing of the arm (HP:0006488)1.87917079
130Clubbing of toes (HP:0100760)1.87193460
131Facial cleft (HP:0002006)1.87191801
132Overriding aorta (HP:0002623)1.86483108
133Easy fatigability (HP:0003388)1.86315940
134Glossoptosis (HP:0000162)1.85287016
135CNS hypomyelination (HP:0003429)1.85116154
136Premature rupture of membranes (HP:0001788)1.83724827
137Elfin facies (HP:0004428)1.83686124
138Abnormality of the umbilical cord (HP:0010881)1.83215338
139Congenital hip dislocation (HP:0001374)1.82924428
140Atrophy/Degeneration involving motor neurons (HP:0007373)1.81003449
141Deviation of the thumb (HP:0009603)1.80388102
142Premature skin wrinkling (HP:0100678)1.80287322
143Abnormality of the labia minora (HP:0012880)1.79592050
144Abnormality of the gallbladder (HP:0005264)1.79448200
145Hemorrhage of the eye (HP:0011885)1.79429829
146Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78984651
147Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77652379
148Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77652379
149Thrombocytosis (HP:0001894)1.77029104
150Increased nuchal translucency (HP:0010880)1.75980750
151Slender long bone (HP:0003100)1.75837562
152J-shaped sella turcica (HP:0002680)1.75625458
153Abnormality of reticulocytes (HP:0004312)1.75293792
154Self-mutilation (HP:0000742)1.74229109
155Elbow flexion contracture (HP:0002987)1.73198601
156Thin ribs (HP:0000883)1.72981959
157Abnormal spermatogenesis (HP:0008669)1.72875019
158Lower limb amyotrophy (HP:0007210)1.72562052
159Nephroblastoma (Wilms tumor) (HP:0002667)1.72518031
160Truncus arteriosus (HP:0001660)1.72233620
161Male infertility (HP:0003251)1.71262925
162Type I transferrin isoform profile (HP:0003642)1.70483482
163Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.70409012
164Abnormal protein N-linked glycosylation (HP:0012347)1.70409012
165Abnormal protein glycosylation (HP:0012346)1.70409012
166Abnormal glycosylation (HP:0012345)1.70409012
167Choanal atresia (HP:0000453)1.70210554
168Entropion (HP:0000621)1.70136498
169Increased serum lactate (HP:0002151)1.69487212
170Broad face (HP:0000283)1.69486663
171Abnormality of glycolysis (HP:0004366)1.69429394
172Joint stiffness (HP:0001387)1.66512708
173Increased muscle lipid content (HP:0009058)1.62869273
174Abnormality of the distal phalanges of the toes (HP:0010182)1.62808209
175Upper limb muscle weakness (HP:0003484)1.62522751
176Bulbar palsy (HP:0001283)1.62375804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.91840159
2WEE14.07168485
3TRIB33.58543615
4SMG13.56398980
5CDC73.49943417
6PASK3.36907067
7EIF2AK13.30034959
8STK162.68285958
9NME22.52699755
10SRPK12.50028725
11NEK22.48876295
12TSSK62.41750344
13TLK12.36447054
14TTK2.26810550
15SIK12.23381138
16TESK22.11329620
17VRK22.07204364
18MKNK12.01016208
19PLK42.00097466
20BRSK21.98644372
21PLK11.96379243
22ERN11.91662274
23ACVR1B1.88528453
24ICK1.85082500
25PRPF4B1.83809035
26MKNK21.79133039
27VRK11.76065058
28CDK71.74855602
29EIF2AK31.71712888
30DYRK31.71269334
31MST1R1.66617728
32ATR1.59247460
33EPHA21.57392860
34AURKB1.54704181
35RPS6KA41.51470269
36ARAF1.49400256
37PRKD31.47742362
38ZAK1.42392211
39PLK31.38241506
40CDK121.34190211
41AURKA1.33813372
42BRSK11.32723809
43MUSK1.29265917
44NEK11.28576462
45CHEK21.28422157
46TTN1.26232812
47CDK41.25505569
48RPS6KB21.22755496
49PIM21.18435847
50MAP3K81.17837866
51CHEK11.16110672
52PAK41.05098216
53CCNB11.02507039
54EEF2K0.95530373
55CDK80.92356022
56LMTK20.90976883
57MAPK110.88657679
58STK100.87320607
59BCKDK0.85503360
60DAPK10.84018296
61STK40.83572020
62EIF2AK20.83316460
63TGFBR10.82841426
64SCYL20.80807711
65MAPK150.79942105
66MAP3K110.78645927
67CDK20.78136695
68TBK10.77434562
69KDR0.77356672
70PIM10.75282969
71RPS6KA20.71935846
72PAK10.71819594
73ATM0.71401576
74LIMK10.70517022
75CSNK2A20.68818593
76BRD40.68201747
77PRKD20.67761039
78ALK0.66076122
79BRAF0.66009410
80CLK10.64661133
81CSNK2A10.64442957
82MAP4K10.61233439
83CDK190.60257288
84TESK10.60115386
85PRKCI0.60048035
86BMX0.59697100
87MAP3K100.59427823
88SIK20.59356731
89FGFR40.59079000
90IRAK20.59036045
91IRAK30.58462738
92CDK11A0.57078696
93RPS6KA50.56916923
94AKT30.56903533
95PDPK10.56177229
96RPS6KL10.56037448
97RPS6KC10.56037448
98EPHB10.55802682
99FLT30.55019992
100MOS0.53337482
101CDK10.52407726
102PTK60.52104469
103BLK0.51493331
104TAOK20.51397112
105NME10.50235715
106MAP2K30.50201380
107KSR20.49195313
108MAP3K10.48706341
109RAF10.46853491
110MAPKAPK20.46168579
111CDK150.45746469
112PTK20.45261484
113MAP2K20.45194860
114AKT20.44592328
115CDK90.43810821
116DAPK30.43230785
117ABL20.42372891
118MELK0.42190637
119CDK140.42028946
120MET0.40658857
121CDK180.40101844
122CSNK1E0.39776074
123LATS20.36875954
124MAP3K30.35400197
125TEC0.34938702
126ZAP700.34418323
127PAK20.33050289
128PDK30.32568796
129PDK40.32568796
130STK30.30477910
131BTK0.29733735
132PBK0.28657240
133YES10.27722185
134MTOR0.26935016
135DYRK20.25444385
136STK38L0.23625141
137IRAK40.22876250
138PRKDC0.22603506
139IKBKB0.19177494
140MAPKAPK30.18299121
141GRK60.17860629
142PKN20.17448594
143SIK30.16071666
144MAPK140.14798485

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.76849917
2Mismatch repair_Homo sapiens_hsa034304.00540191
3* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.97369390
4RNA polymerase_Homo sapiens_hsa030203.68276409
5Ribosome_Homo sapiens_hsa030103.62313870
6Spliceosome_Homo sapiens_hsa030403.35773817
7Proteasome_Homo sapiens_hsa030503.18893671
8Base excision repair_Homo sapiens_hsa034103.17283376
9RNA transport_Homo sapiens_hsa030133.11083517
10Homologous recombination_Homo sapiens_hsa034403.03129077
11One carbon pool by folate_Homo sapiens_hsa006702.82324273
12Nucleotide excision repair_Homo sapiens_hsa034202.74093771
13Pyrimidine metabolism_Homo sapiens_hsa002402.68123381
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.63284244
15Cell cycle_Homo sapiens_hsa041102.52456744
16Fanconi anemia pathway_Homo sapiens_hsa034602.28800964
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99089218
18Basal transcription factors_Homo sapiens_hsa030221.94155555
19Vitamin B6 metabolism_Homo sapiens_hsa007501.93370603
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80863282
21Non-homologous end-joining_Homo sapiens_hsa034501.79383741
22RNA degradation_Homo sapiens_hsa030181.67581788
23mRNA surveillance pathway_Homo sapiens_hsa030151.64515849
24p53 signaling pathway_Homo sapiens_hsa041151.59966028
25Other glycan degradation_Homo sapiens_hsa005111.59511113
26Purine metabolism_Homo sapiens_hsa002301.49152279
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.48884482
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41379578
29Folate biosynthesis_Homo sapiens_hsa007901.35579957
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30162136
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22681438
32Sulfur relay system_Homo sapiens_hsa041221.21970722
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20114067
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.19239790
35Epstein-Barr virus infection_Homo sapiens_hsa051691.16206283
36Pyruvate metabolism_Homo sapiens_hsa006201.10404516
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.05571540
38Phenylalanine metabolism_Homo sapiens_hsa003601.03533853
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.02503191
40Systemic lupus erythematosus_Homo sapiens_hsa053221.02344699
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93633664
42Fatty acid elongation_Homo sapiens_hsa000620.90807018
43Pentose phosphate pathway_Homo sapiens_hsa000300.90236458
44Biosynthesis of amino acids_Homo sapiens_hsa012300.89577348
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.88501971
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88228022
47Arginine biosynthesis_Homo sapiens_hsa002200.88064263
48Herpes simplex infection_Homo sapiens_hsa051680.83306286
49Viral carcinogenesis_Homo sapiens_hsa052030.83001324
50Selenocompound metabolism_Homo sapiens_hsa004500.82015519
51Antigen processing and presentation_Homo sapiens_hsa046120.73456134
52Oocyte meiosis_Homo sapiens_hsa041140.72212844
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71211150
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68874952
55HTLV-I infection_Homo sapiens_hsa051660.67845178
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64390540
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59937472
58Non-small cell lung cancer_Homo sapiens_hsa052230.56210631
59Pancreatic cancer_Homo sapiens_hsa052120.54979987
60Glutathione metabolism_Homo sapiens_hsa004800.54767471
61VEGF signaling pathway_Homo sapiens_hsa043700.53256770
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53142025
63Protein export_Homo sapiens_hsa030600.51333282
64Prion diseases_Homo sapiens_hsa050200.49225429
65Huntingtons disease_Homo sapiens_hsa050160.48452397
66Thyroid cancer_Homo sapiens_hsa052160.47355458
67Lysosome_Homo sapiens_hsa041420.47205315
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47132562
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46981342
70Basal cell carcinoma_Homo sapiens_hsa052170.46288416
71Legionellosis_Homo sapiens_hsa051340.46197690
72MicroRNAs in cancer_Homo sapiens_hsa052060.46034928
73Vibrio cholerae infection_Homo sapiens_hsa051100.45999289
74Carbon metabolism_Homo sapiens_hsa012000.44511721
75Fructose and mannose metabolism_Homo sapiens_hsa000510.43725958
76AMPK signaling pathway_Homo sapiens_hsa041520.43280169
77Notch signaling pathway_Homo sapiens_hsa043300.42685358
78Primary immunodeficiency_Homo sapiens_hsa053400.42284468
79Small cell lung cancer_Homo sapiens_hsa052220.40949725
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39271325
81N-Glycan biosynthesis_Homo sapiens_hsa005100.38073481
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37785616
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37371631
84Apoptosis_Homo sapiens_hsa042100.37119208
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36457492
86Bladder cancer_Homo sapiens_hsa052190.36001497
87Vitamin digestion and absorption_Homo sapiens_hsa049770.33769212
88Insulin signaling pathway_Homo sapiens_hsa049100.33079574
89Arginine and proline metabolism_Homo sapiens_hsa003300.31294765
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31186965
91Metabolic pathways_Homo sapiens_hsa011000.31130176
92Endocytosis_Homo sapiens_hsa041440.31042240
93Hippo signaling pathway_Homo sapiens_hsa043900.29794095
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29118805
95Fatty acid metabolism_Homo sapiens_hsa012120.29004281
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28950589
97Galactose metabolism_Homo sapiens_hsa000520.28752940
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.28726209
99Measles_Homo sapiens_hsa051620.27620059
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27552648
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.27399637
102Salmonella infection_Homo sapiens_hsa051320.26853305
103Alcoholism_Homo sapiens_hsa050340.26620541
104Viral myocarditis_Homo sapiens_hsa054160.25435767
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24617960
106Tyrosine metabolism_Homo sapiens_hsa003500.23814995
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23802694
108Parkinsons disease_Homo sapiens_hsa050120.23534141
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23341306
110Sphingolipid metabolism_Homo sapiens_hsa006000.22976562
111Regulation of autophagy_Homo sapiens_hsa041400.21356169
112Hedgehog signaling pathway_Homo sapiens_hsa043400.21102723
113Hepatitis B_Homo sapiens_hsa051610.20407216
114Arachidonic acid metabolism_Homo sapiens_hsa005900.20232582
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19784567
116Renin-angiotensin system_Homo sapiens_hsa046140.18679251
117TGF-beta signaling pathway_Homo sapiens_hsa043500.18005738
118HIF-1 signaling pathway_Homo sapiens_hsa040660.17861800
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.16329786
120Hematopoietic cell lineage_Homo sapiens_hsa046400.16167882
121Shigellosis_Homo sapiens_hsa051310.14964011
122Colorectal cancer_Homo sapiens_hsa052100.14329818
123Pathways in cancer_Homo sapiens_hsa052000.13623559
124Influenza A_Homo sapiens_hsa051640.13348520
125Acute myeloid leukemia_Homo sapiens_hsa052210.08949685
126Chronic myeloid leukemia_Homo sapiens_hsa052200.08036450
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.07879342
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07435309
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07105249
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06933898
131Lysine degradation_Homo sapiens_hsa003100.03759241

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